Radiomics improves efficiency for differentiating subclinical pheochromocytoma from lipid-poor adenoma: a predictive, preventive and personalized medical approach in adrenal incidentalomas
ConclusionsOur radiomic nomograms based on pre-enhanced and enhanced CT images distinguished sPHEO from LPA. In addition, the promising result using  pre-enhanced CT images for predictive diagnostics is important because patients could avoid the additional radiation and risk associated with enhanced CT. (Source: EPMA Journal)
Source: EPMA Journal - September 21, 2018 Category: International Medicine & Public Health Source Type: research

Efficiency of dental caries prevention with the use of polymer-based toothpastes modified by the electromagnetic field
AbstractThe most important problems of modern dentistry cover not only the early diagnosis but also prevention of dental caries, including the one based on the use of various hygienic products and therapeutic agents. Normally, the processes of re- and demineralization in the oral cavity are in a state of dynamic. However, in the presence of cariogenic factors, the balance is shifted towards demineralization. In the event of initial caries, enamel remineralization is possible only to a certain extent, and specifically, for a reversible degree of carious lesion. There was an idea about structural changes in polymer-based con...
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Liquid biopsy and multiparametric analysis in management of liver malignancies: new concepts of the patient stratification and prognostic approach
AbstractBackgroundThe annually recorded incidence of primary hepatic carcinomas has significantly increased over the past two decades accounting for over 800 thousand of annual deaths caused by hepatocellular carcinoma (HCC) alone globally. Further, secondary liver malignancies are much more widespread compared to primary hepatic carcinomas: almost all solid malignancies are able to metastasise into the liver. The primary tumours most frequently metastasising to the liver are breast followed by colorectal carcinomas. Given the increased incidence of both primary and metastatic liver cancers, a new, revised approach is need...
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Current approaches in the clinical management of pregnancy-associated breast cancer —pros and cons
AbstractMalignancies are one of the leading causes of mortality in women during their reproductive life. Treatment of gynecological malignant tumors during pregnancy is possible but not simple, since it creates a conflict between care of the mother and the fetus. BC is the most prevalent malignancy diagnosed in pregnancy, ranking up to 21% of all pregnancy-related malignancies. Due to its stets increasing prevalence, aggressive cancer subtype, and severe ethical and psychological aspects linked to the disease, experts raise an alarm for an acute necessity to improve the overall management of the PABC —the issue which...
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

A new non-invasive diagnostic tool in coronary artery disease: artificial intelligence as an essential element of predictive, preventive, and personalized medicine
ConclusionsThe successful use of the MPA approach has been demonstrated in a broad-risk spectrum of patients undergoing CAD evaluation, as an element of predictive, preventive, personalized medicine, and may be used instead of further non-invasive diagnostic procedures. (Source: EPMA Journal)
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Neuromyelitis optica spectrum disorders and pregnancy: relapse-preventive measures and personalized treatment strategies
This study reviews, on the one hand, the role NMOSD play in fertility, pregnancy complications and pregnancy outcome, and on the other, the effect of pregnancy on NMOSD disease course and treatment options available during pregnancy. Animal studies show lower fertility rates in NMOSD; however, investigations into fertility in NMOSD patients are lacking. Pregnancies in NMOSD patients are associated with increased disease activity and more severe disability postpartum. Some studies found higher risks of pregnancy complications, e.g., miscarriages and preeclampsia. Acute relapses during pregnancy can be treated with methylpre...
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

“Dry mouth” and “Flammer” syndromes—neglected risks in adolescents and new concepts by predictive, preventive and personalised approach
In conclusion, FS questionnaire linked to the “dry mouth” syndrome is strongly recommended for application in primary healthcare. Consequently, targeted preventive measures can be triggered early in life. For example, traditional, complementary and alternative me dicine demonstrates positive therapeutic effects in individuals suffering from xerostomia. For in-depth diagnostics, epi/genetic regulations involved into pathophysiologic mechanisms of hyposalivation in FS-affected individuals should be thoroughly investigated at molecular level. Identified biomark er panels might be of great clinical utility for pred...
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Titanium implants and silent inflammation in jawbone —a critical interplay of dissolved titanium particles and cytokines TNF-α and RANTES/CCL5 on overall health?
ConclusionFrom a systemic perspective, we recommend that more attention be paid to the cytokine cross-talk that is provoked by dissolved Ti particles from DTI in medicine and dentistry. This may contribute to further development of personalized strategies in preventive medicine. (Source: EPMA Journal)
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Biorepository and integrative genomics initiative: designing and implementing a preliminary platform for predictive, preventive and personalized medicine at a pediatric hospital in a historically disadvantaged community in the USA
AbstractCurrent healthcare is evolving to emphasize cost-effective care by leveraging results and outcomes of genomic and other advanced research efforts in clinical care and preventive health planning. Through a collaborative effort between the University of Tennessee Health Science Center (UTHSC) and Le Bonheur Children ’s Hospital (LBCH), the Biorepository and Integrative Genomics (BIG) Initiative was established to set up a pediatric-based DNA biorepository that can serve as a foundation for successful development of delivery platforms for predictive, preventive, and personalized medical services in Memphis, Te n...
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Individualized metabolic profiling stratifies pancreatic and biliary tract cancer: a useful tool for innovative screening programs and predictive strategies in healthcare
This study not only details efficient methods to identify discriminative LMIs for cancer screening but also provides an example of metabolic profiling for distinguishing PC from BTC. Furthermore, the two metabolites [LysoPC(16:0), LysoPC(20:4)] shown to discriminate these diseases are potentially useful when combined with other, previously identified protein or metabolic biomarkers for predictive, preventive and personalized medical approach. (Source: EPMA Journal)
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Latent class analysis to evaluate performance of plasma cortisol, plasma catecholamines, and SHSQ-25 for early recognition of suboptimal health status
ConclusionPlasma cortisol is a valuable biomarker for SHS detection, whereas SHSQ-25 is more suitable for SHS screening in the population-based health survey. The accuracy and applicability of plasma adrenaline are inferior to cortisol and SHSQ-25, respectively. LCA has merit to evaluate performance of plasma cortisol, catecholamines, and SHSQ-25 for recognition of SHS in the absence of a gold standard test. (Source: EPMA Journal)
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Suboptimal health status and psychological symptoms among Chinese college students: a perspective of predictive, preventive and personalised health
ConclusionsOur findings confirm that there is a high prevalence of SHS among college students and there is a strong association between SHS and psychological symptoms among Chinese college students. High susceptibility of SHS occurs particularly in vulnerable groups: female students, sophomore students, medical students and students from rural area. Identification of SHS and prompt application of personalised psychological health-supporting activities will promote college students ’ health status. (Source: EPMA Journal)
Source: EPMA Journal - August 28, 2018 Category: International Medicine & Public Health Source Type: research

Liquid biopsy and multiparametric analysis in management of liver malignancies: new concepts of the patient stratification and prognostic approach
AbstractBackgroundThe annually recorded incidence of primary hepatic carcinomas has significantly increased over the past two decades accounting for over 800 thousand of annual deaths caused by hepatocellular carcinoma (HCC) alone globally. Further, secondary liver malignancies are much more widespread compared to primary hepatic carcinomas: almost all solid malignancies are able to metastasise into the liver. The primary tumours most frequently metastasising to the liver are breast followed by colorectal carcinomas. Given the increased incidence of both primary and metastatic liver cancers, a new, revised approach is need...
Source: EPMA Journal - August 17, 2018 Category: International Medicine & Public Health Source Type: research

Individualized metabolic profiling stratifies pancreatic and biliary tract cancer: a useful tool for innovative screening programs and predictive strategies in healthcare
This study not only details efficient methods to identify discriminative LMIs for cancer screening but also provides an example of metabolic profiling for distinguishing PC from BTC. Furthermore, the two metabolites [LysoPC(16:0), LysoPC(20:4)] shown to discriminate these diseases are potentially useful when combined with other, previously identified protein or metabolic biomarkers for predictive, preventive and personalized medical approach. (Source: EPMA Journal)
Source: EPMA Journal - August 17, 2018 Category: International Medicine & Public Health Source Type: research

A new non-invasive diagnostic tool in coronary artery disease: artificial intelligence as an essential element of predictive, preventive, and personalized medicine
ConclusionsThe successful use of the MPA approach has been demonstrated in a broad-risk spectrum of patients undergoing CAD evaluation, as an element of predictive, preventive, personalized medicine, and may be used instead of further non-invasive diagnostic procedures. (Source: EPMA Journal)
Source: EPMA Journal - August 16, 2018 Category: International Medicine & Public Health Source Type: research

Efficiency of dental caries prevention with the use of polymer-based toothpastes modified by the electromagnetic field
AbstractThe most important problems of modern dentistry cover not only the early diagnosis but also prevention of dental caries, including the one based on the use of various hygienic products and therapeutic agents. Normally, the processes of re- and demineralization in the oral cavity are in a state of dynamic. However, in the presence of cariogenic factors, the balance is shifted towards demineralization. In the event of initial caries, enamel remineralization is possible only to a certain extent, and specifically, for a reversible degree of carious lesion. There was an idea about structural changes in polymer-based con...
Source: EPMA Journal - August 14, 2018 Category: International Medicine & Public Health Source Type: research

Neuromyelitis optica spectrum disorders and pregnancy: relapse-preventive measures and personalized treatment strategies
This study reviews, on the one hand, the role NMOSD play in fertility, pregnancy complications and pregnancy outcome, and on the other, the effect of pregnancy on NMOSD disease course and treatment options available during pregnancy. Animal studies show lower fertility rates in NMOSD; however, investigations into fertility in NMOSD patients are lacking. Pregnancies in NMOSD patients are associated with increased disease activity and more severe disability postpartum. Some studies found higher risks of pregnancy complications, e.g., miscarriages and preeclampsia. Acute relapses during pregnancy can be treated with methylpre...
Source: EPMA Journal - August 10, 2018 Category: International Medicine & Public Health Source Type: research

“Dry mouth” and “Flammer” syndromes—neglected risks in adolescents and new concepts by predictive, preventive and personalised approach
In conclusion, FS questionnaire linked to the “dry mouth” syndrome is strongly recommended for application in primary healthcare. Consequently, targeted preventive measures can be triggered early in life. For example, traditional, complementary and alternative me dicine demonstrates positive therapeutic effects in individuals suffering from xerostomia. For in-depth diagnostics, epi/genetic regulations involved into pathophysiologic mechanisms of hyposalivation in FS-affected individuals should be thoroughly investigated at molecular level. Identified biomark er panels might be of great clinical utility for pred...
Source: EPMA Journal - August 2, 2018 Category: International Medicine & Public Health Source Type: research

Biorepository and integrative genomics initiative: designing and implementing a preliminary platform for predictive, preventive and personalized medicine at a pediatric hospital in a historically disadvantaged community in the USA
AbstractCurrent healthcare is evolving to emphasize cost-effective care by leveraging results and outcomes of genomic and other advanced research efforts in clinical care and preventive health planning. Through a collaborative effort between the University of Tennessee Health Science Center (UTHSC) and Le Bonheur Children ’s Hospital (LBCH), the Biorepository and Integrative Genomics (BIG) Initiative was established to set up a pediatric-based DNA biorepository that can serve as a foundation for successful development of delivery platforms for predictive, preventive, and personalized medical services in Memphis, Te n...
Source: EPMA Journal - August 2, 2018 Category: International Medicine & Public Health Source Type: research

Latent class analysis to evaluate performance of plasma cortisol, plasma catecholamines, and SHSQ-25 for early recognition of suboptimal health status
ConclusionPlasma cortisol is a valuable biomarker for SHS detection, whereas SHSQ-25 is more suitable for SHS screening in the population-based health survey. The accuracy and applicability of plasma adrenaline are inferior to cortisol and SHSQ-25, respectively. LCA has merit to evaluate performance of plasma cortisol, catecholamines, and SHSQ-25 for recognition of SHS in the absence of a gold standard test. (Source: EPMA Journal)
Source: EPMA Journal - August 1, 2018 Category: International Medicine & Public Health Source Type: research

Current approaches in the clinical management of pregnancy-associated breast cancer —pros and cons
AbstractMalignancies are one of the leading causes of mortality in women during their reproductive life. Treatment of gynecological malignant tumors during pregnancy is possible but not simple, since it creates a conflict between care of the mother and the fetus. BC is the most prevalent malignancy diagnosed in pregnancy, ranking up to 21% of all pregnancy-related malignancies. Due to its stets increasing prevalence, aggressive cancer subtype, and severe ethical and psychological aspects linked to the disease, experts raise an alarm for an acute necessity to improve the overall management of the PABC —the issue which...
Source: EPMA Journal - June 24, 2018 Category: International Medicine & Public Health Source Type: research

Titanium implants and silent inflammation in jawbone —a critical interplay of dissolved titanium particles and cytokines TNF-α and RANTES/CCL5 on overall health?
ConclusionFrom a systemic perspective, we recommend that more attention be paid to the cytokine cross-talk that is provoked by dissolved Ti particles from DTI in medicine and dentistry. This may contribute to further development of personalized strategies in preventive medicine. (Source: EPMA Journal)
Source: EPMA Journal - June 8, 2018 Category: International Medicine & Public Health Source Type: research

Novel concept to guide systolic heart failure medication by repeated biomarker testing —results from TIME-CHF in context of predictive, preventive, and personalized medicine
ConclusionThe data of this post hoc analysis suggest that decision-making using repeated biomarker measurements may be very promising in bringing treatment of heart failure to a new level in the context of predictive, preventive, and personalized medicine. Clearly, prospective testing is needed before this novel concept can be adopted.Clinical trial registrationisrctn.org, identifier: ISRCTN43596477 (Source: EPMA Journal)
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Premenopausal breast cancer: potential clinical utility of a multi-omics based machine learning approach for patient stratification
AbstractBackgroundThe breast cancer (BC) epidemic is a multifactorial disease attributed to the early twenty-first century: about two million of new cases and half a million deaths are registered annually worldwide. New trends are emerging now: on the one hand, with respect to the geographical BC prevalence and, on the other hand, with respect to the age distribution. Recent statistics demonstrate that young populations are getting more and more affected by BC in both Eastern and Western countries. Therefore, the old rule “the older the age, the higher the BC risk” is getting relativised now. Accumulated eviden...
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Mental stress as consequence and cause of vision loss: the dawn of psychosomatic ophthalmology for preventive and personalized medicine
AbstractThe loss of vision after damage to the retina, optic nerve, or brain has often grave consequences in everyday life such as problems with recognizing faces, reading, or mobility. Because vision loss is considered to be irreversible and often progressive, patients experience continuous mental stress due to worries, anxiety, or fear with secondary consequences such as depression and social isolation. While prolonged mental stress is clearly aconsequence of vision loss, it may also aggravate the situation. In fact, continuous stress and elevated cortisol levels negatively impact the eye and brain due to autonomous nerv...
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Preventive, predictive, and personalized medicine for effective and affordable cancer care
AbstractPreventive, predictive, and personalized medicine (PPPM) has created a wealth of new opportunities but added also new complexities and challenges. The European Cancer Prevention Organization already embraced unanimously molecular biology for primary and secondary prevention. The rapidly exploding genomic language and complexity of methods face oncologists with exponentially growing knowledge they need to assess and apply. Tissue specimen quality becomes one major concern. Some new innovative medicines cost beyond any reasonable threshold of financial support from patients, health care providers, and governments and...
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Specific properties of probiotic strains: relevance and benefits for the host
ConclusionWe recognized strain-dependent properties of studied LAB and bifidobacteria probiotic strains (adhesive ability, resistance to antibiotics, and gut biological fluids) and discussed potential for most effective individualized treatment for gut and distant sites microbiome modulation. (Source: EPMA Journal)
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Pathology-specific molecular profiles of saliva in patients with multiple dental caries —potential application for predictive, preventive and personalised medical services
ConclusionThe detected features in the IR spectra of mixed saliva as well as the calculated changes in the ratios between organic and inorganic components can be used as biomarkers of cariogenesis in the oral cavity, as a diagnostic criterion in the analysis of the oral fluid samples. (Source: EPMA Journal)
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Diabetes care in figures: current pitfalls and future scenario
AbstractDiabetes mellitus (DM) epidemic —on a global scale—is a major and snowballing threat to public health, healthcare systems and economy, due to the cascade of pathologies triggered in a long-term manner after the DM manifestation. There are remarkable differences in the geographic disease spread and acceleration of an increasing DM prevalence recorded. Specifically, the highest initial prevalence of DM was recorded in the Eastern-Mediterranean region in 1980 followed by the highest acceleration of the epidemic characterised by 0.23% of an annual increase resulted in 2.3 times higher prevalence in the year...
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

The influence of mothers ’ oral health behaviour and perception thereof on the dental health of their children
AbstractObjectiveThe study aims to investigate how mothers ’ oral health behaviour and perception thereof influence the dental health in their children.MethodsA total of 556 Vietnamese mother –child pairs participated in the current study. Mothers self-reported their oral status and oral health behaviour and perception. Dental caries of the children were examined using the index of decayed, missing, and filled teeth. The Dental Anxiety Scale instrument was used to assess the dental anx iety level in mothers and children.ResultsAmong mothers, 41.3% had gingival bleeding, 40% perceived their dentition and gingiva...
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Diabetes care in figures: current pitfalls and future scenario
AbstractDiabetes mellitus (DM) epidemic —on a global scale—is a major and snowballing threat to public health, healthcare systems and economy, due to the cascade of pathologies triggered in a long-term manner after the DM manifestation. There are remarkable differences in the geographic disease spread and acceleration of an increasing DM prevalence recorded. Specifically, the highest initial prevalence of DM was recorded in the Eastern-Mediterranean region in 1980 followed by the highest acceleration of the epidemic characterised by 0.23% of an annual increase resulted in 2.3 times higher prevalence in the year...
Source: EPMA Journal - May 22, 2018 Category: International Medicine & Public Health Source Type: research

Novel concept to guide systolic heart failure medication by repeated biomarker testing —results from TIME-CHF in context of predictive, preventive, and personalized medicine
ConclusionThe data of this post hoc analysis suggest that decision-making using repeated biomarker measurements may be very promising in bringing treatment of heart failure to a new level in the context of predictive, preventive, and personalized medicine. Clearly, prospective testing is needed before this novel concept can be adopted.Clinical trial registrationisrctn.org, identifier: ISRCTN43596477 (Source: EPMA Journal)
Source: EPMA Journal - May 13, 2018 Category: International Medicine & Public Health Source Type: research

Mental stress as consequence and cause of vision loss: the dawn of psychosomatic ophthalmology for preventive and personalized medicine
AbstractThe loss of vision after damage to the retina, optic nerve, or brain has often grave consequences in everyday life such as problems with recognizing faces, reading, or mobility. Because vision loss is considered to be irreversible and often progressive, patients experience continuous mental stress due to worries, anxiety, or fear with secondary consequences such as depression and social isolation. While prolonged mental stress is clearly aconsequence of vision loss, it may also aggravate the situation. In fact, continuous stress and elevated cortisol levels negatively impact the eye and brain due to autonomous nerv...
Source: EPMA Journal - May 9, 2018 Category: International Medicine & Public Health Source Type: research

The influence of mothers ’ oral health behaviour and perception thereof on the dental health of their children
AbstractObjectiveThe study aims to investigate how mothers ’ oral health behaviour and perception thereof influence the dental health in their children.MethodsA total of 556 Vietnamese mother –child pairs participated in the current study. Mothers self-reported their oral status and oral health behaviour and perception. Dental caries of the children were examined using the index of decayed, missing, and filled teeth. The Dental Anxiety Scale instrument was used to assess the dental anx iety level in mothers and children.ResultsAmong mothers, 41.3% had gingival bleeding, 40% perceived their dentition and gingiva...
Source: EPMA Journal - April 26, 2018 Category: International Medicine & Public Health Source Type: research

Pathology-specific molecular profiles of saliva in patients with multiple dental caries —potential application for predictive, preventive and personalised medical services
ConclusionThe detected features in the IR spectra of mixed saliva as well as the calculated changes in the ratios between organic and inorganic components can be used as biomarkers of cariogenesis in the oral cavity, as a diagnostic criterion in the analysis of the oral fluid samples. (Source: EPMA Journal)
Source: EPMA Journal - April 25, 2018 Category: International Medicine & Public Health Source Type: research

Specific properties of probiotic strains: relevance and benefits for the host
ConclusionWe recognized strain-dependent properties of studied LAB and bifidobacteria probiotic strains (adhesive ability, resistance to antibiotics, and gut biological fluids) and discussed potential for most effective individualized treatment for gut and distant sites microbiome modulation. (Source: EPMA Journal)
Source: EPMA Journal - April 13, 2018 Category: International Medicine & Public Health Source Type: research

Premenopausal breast cancer: potential clinical utility of a multi-omics based machine learning approach for patient stratification
AbstractBackgroundThe breast cancer (BC) epidemic is a multifactorial disease attributed to the early twenty-first century: about two million of new cases and half a million deaths are registered annually worldwide. New trends are emerging now: on the one hand, with respect to the geographical BC prevalence and, on the other hand, with respect to the age distribution. Recent statistics demonstrate that young populations are getting more and more affected by BC in both Eastern and Western countries. Therefore, the old rule “the older the age, the higher the BC risk” is getting relativised now. Accumulated eviden...
Source: EPMA Journal - April 11, 2018 Category: International Medicine & Public Health Source Type: research

Preventive, predictive, and personalized medicine for effective and affordable cancer care
AbstractPreventive, predictive, and personalized medicine (PPPM) has created a wealth of new opportunities but added also new complexities and challenges. The European Cancer Prevention Organization already embraced unanimously molecular biology for primary and secondary prevention. The rapidly exploding genomic language and complexity of methods face oncologists with exponentially growing knowledge they need to assess and apply. Tissue specimen quality becomes one major concern. Some new innovative medicines cost beyond any reasonable threshold of financial support from patients, health care providers, and governments and...
Source: EPMA Journal - March 26, 2018 Category: International Medicine & Public Health Source Type: research

Heart rate variability: the comparison between high tension and normal tension glaucoma
AbstractRelevanceVascular factors may be involved in the development of both high tension glaucoma (HTG) and normal tension (NTG) glaucoma; however, they may be not exactly the same. Autonomic dysfunction characterized by heart rate variability (HRV) is one of the possible reasons of decrease in mean ocular perfusion pressure (MOPP).PurposeTo compare the shift of the HRV parameters in NTG and HTG patients after a cold provocation test (CPT).MethodsMOPP, 24-hour blood pressure and HRV were studied in 30 NTG, 30 HTG patients, and 28 healthy subjects. The cardiovascular fitness assessment was made before and after the CPT. Th...
Source: EPMA Journal - February 22, 2018 Category: International Medicine & Public Health Source Type: research

Individualised patient profile: clinical utility of Flammer syndrome phenotype and general lessons for predictive, preventive and personalised medicine
AbstractThis case report introduces a female patient, who since her teenager age evidently suffers from Flammer syndrome (FS) as the clearly defined sub-optimal health condition. Further, the patient has experienced collateral pathological conditions which primarily might be linked to the family (genetic) predisposition, but the development of which could be synergistically promoted by the FS-phenotype. The facts are thoroughly analysed and consequent hypotheses are presented, which are indicative for highly desirable predictive diagnostics and targeted preventive measures to be created based on the accurate interpretation...
Source: EPMA Journal - February 22, 2018 Category: International Medicine & Public Health Source Type: research

Clinical and laboratory evaluation of microstructural changes in the physical, mechanical and chemical properties of dental filling materials under the influence of an electromagnetic field
AbstractRestorative filling materials used for dental caries prevention and treatment consist of various components including monomers or oligomers, which play a significant role in forming the main structure of these materials, as well as in characterising their physical, mechanical and chemical properties. The necessity for the development and improvement of structural characteristics of polymeric dental filling materials intended for caries prevention and their life duration increase served as the initiating factor of our research. According to the research purpose and challenges, we studied the changes in the physical,...
Source: EPMA Journal - February 21, 2018 Category: International Medicine & Public Health Source Type: research

The crucial role of multiomic approach in cancer research and clinically relevant outcomes
AbstractCancer with heavily economic and social burden is the hot point in the field of medical research. Some remarkable achievements have been made; however, the exact mechanisms of tumor initiation and development remain unclear. Cancer is a complex, whole-body disease that involves multiple abnormalities in the levels of DNA, RNA, protein, metabolite and medical imaging. Biological omics including genomics, transcriptomics, proteomics, metabolomics and radiomics aims to systematically understand carcinogenesis in different biological levels, which is driving the shift of cancer research paradigm from single parameter m...
Source: EPMA Journal - February 21, 2018 Category: International Medicine & Public Health Source Type: research

Implementation of personalized medicine in Central-Eastern Europe: pitfalls and potentials based on citizen ’s attitude
ConclusionsWe think that given the controversies and complexities of the next-generation sequencing field, the optimal clinical translation of NGS data should be performed in institutions which have the unique capability to provide interprofessional health education, transformative biomedical research, and crucial patient care. With optimization of the clinical translational process, improvement of genetic literacy may increase patient engagement and empowerment.Relevance of the article for predictive, preventive, and personalized medicineThe paper highlights that in countries with relatively low-genetic literacy, a specia...
Source: EPMA Journal - February 9, 2018 Category: International Medicine & Public Health Source Type: research

Pregnancy-associated breast cancer: the risky status quo and new concepts of predictive medicine
AbstractThe paper is motivated by severe concerns regarding currently applied care of the pregnancy-associated breast cancer (PABC) characterised by particularly poor outcomes of the disease. Psychological and ethical aspects play a crucial role in PABC: the highest priority not to damage the foetus significantly complicates any treatment generally, and it is quite usual that patients disclaim undergoing any breast cancer treatment during pregnancy. Although, due to global demographic trends, PABC is far from appearing rarely now, severe societal and economic consequences of the disease are still neglected by currently app...
Source: EPMA Journal - February 8, 2018 Category: International Medicine & Public Health Source Type: research

Optical coherence tomography in neuromyelitis optica spectrum disorders: potential advantages for individualized monitoring of progression and therapy
This article summarizes retinal involvement in NMOSD and reviews OCT methods that could be used now and in the future, for differential diagnosis, for monitoring of disease course, and in clinical trials. (Source: EPMA Journal)
Source: EPMA Journal - December 22, 2017 Category: International Medicine & Public Health Source Type: research

Vitamin D in the prevention, prediction and treatment of neurodegenerative and neuroinflammatory diseases
AbstractVitamin D research has gained increased attention in recent times due to its roles beyond bone health and calcium homeostasis, such as immunomodulation. In some parts of the brain and on immune cells, vitamin D hydroxylating enzymes and its receptors are located. Epidemiological evidence demonstrates that deficiency of Vitamin D is relevant for disease risk and course in multiple sclerosis (MS) and presumably also in neuromyelitis optica spectrum disorders (NMOSD), Parkinson ’s disease (PD), and Alzheimer’s disease (AD). Although the exact mechanism underlying vitamin D effects in these diseases remains...
Source: EPMA Journal - November 15, 2017 Category: International Medicine & Public Health Source Type: research

Incorporation of suboptimal health status as a potential risk assessment for type II diabetes mellitus: a case-control study in a Ghanaian population
AbstractDue to a paradigm shift in lifestyles, there is growing concern that type 2 diabetes mellitus (T2DM) will reach epidemic proportions in Ghana. However, specific characteristics of the disease are under explored in this region. More challenging are those yet to be diagnosed or who complain of poor health in the absence of a diagnosed disease —suboptimal health status (SHS). We conducted a study to examine various factors that characterise SHS and T2DM. Using a cross-sectional design, we recruited 264 people as controls and 241 T2DM patients from January to June 2016. The controls were categorised into high and...
Source: EPMA Journal - October 18, 2017 Category: International Medicine & Public Health Source Type: research

High regenerative capacity of the liver and irreversible injury of male reproductive system in carbon tetrachloride-induced liver fibrosis rat model
AbstractBackgroundLiver fibrosis (LF) is a chronic disease, associated with many collateral diseases including reproductive dysfunction. Although the normal liver has a large regenerative capacity the complications of LF could be severe and irreversible. Hormone and sex-related issues of LF development and interactions with male reproductive have not been finally studied. The aim was to study the reproductive function of male rats in experimental CCl4-induced liver fibrosis rat model, and the capability for restoration of both the liver and male reproduction system.MaterialsStudies were conducted on 20 3-month old Wistar m...
Source: EPMA Journal - October 11, 2017 Category: International Medicine & Public Health Source Type: research