Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach
AbstractStroke is one of the most devastating pathologies of the early twenty-first century demonstrating 1-month case-fatality rates ranging from 13 to 35% worldwide. Though the majority of cases do occur in individuals at an advanced age, a persistently increasing portion of the patient cohorts is affected early in life. Current studies provide alarming statistics for the incidence of “young” strokes including adolescents. Young stroke is a multifactorial disease involving genetic predisposition but also a number of modifiable factors, the synergic combination of which potentiates the risks. The article analy...
Source: EPMA Journal - February 20, 2019 Category: International Medicine & Public Health Source Type: research

The circadian expression of osteogenic factors in periodontal tissue loading mechanical force: new concepts of the personalized orthodontic care
ConclusionsThis study indicates the existence of a circadian rhythm of the osteogenic factors within the orthodontic sensitive tissues, which highlights the importance of precise timing of force loading in further orthodontic treatment. Thus, a periodicity pattern of orthodontic traction at night may prove a more efficient tooth movement while minimizing the treatment window and discomfort complains. (Source: EPMA Journal)
Source: EPMA Journal - February 18, 2019 Category: International Medicine & Public Health Source Type: research

Suboptimal health status as an independent risk factor for type 2 diabetes mellitus in a community-based cohort: the China suboptimal health cohort study
ConclusionsThe present study suggests that a higher SHS score is associated with a higher incidence of T2DM. SHS is a new independent risk factor for T2DM and has the capability to act as a predictive tool for T2DM onset. The evaluation of SHS combined with the analysis of modifiable risk factors for SHS allows the risk stratification of T2DM, which may consequently contribute to the prevention of T2DM development. These findings might require further validation in a longer-term follow-up study. (Source: EPMA Journal)
Source: EPMA Journal - January 24, 2019 Category: International Medicine & Public Health Source Type: research

Value of pre-operative CTX serum levels in the prediction of medication-related osteonecrosis of the jaw (MRONJ): a retrospective clinical study
ConclusionsSerum levels of CTX by itself are not reliable as a predictive or preventive measure for such complications. Our data also suggested that a drug holiday of 5  months was not helpful in preventing osteonecrosis-related complications in patients on intravenous bisphosphonates. Further studies are urgently needed to develop adequate predictive and preventive strategies of MRONJ. (Source: EPMA Journal)
Source: EPMA Journal - January 24, 2019 Category: International Medicine & Public Health Source Type: research

Oral burning: local and systemic connection for a patient-centric approach
AbstractBurning symptoms in the oral cavity are caused by a range of systemic and local factors, in addition to the neuropathic pain disorder burning mouth syndrome (BMS). Patients may state oral burning as a standalone symptom or may report as a secondary symptom in association with other factors, most commonly with oral dryness, oral mucosal lesions, or certain systemic conditions. There is a level of uncertainty in the presentation of this condition which creates a diagnostic challenge from both the patient ’s perspective and the practitioner evaluating these individuals. The diagnoses are complicated due to the l...
Source: EPMA Journal - January 14, 2019 Category: International Medicine & Public Health Source Type: research

Review of herbal medications with the potential to cause bleeding: dental implications, and risk prediction and prevention avenues
AbstractMedicinal plant products have been used in health care since time immemorial. During the past three decades, the use of herbal supplements has been on the rise in the USA. A number of these products have been shown to possess the potential to interfere with blood clotting. This paper is a review of blood-thinning herbal supplements commonly used in the USA, accompanied by discussion of the dental implications of their use along with suggestions for prediction and prevention of the risk of bleeding. Twenty herbal supplements belonging to four pharmacological groups are identified and reviewed. While the majority (45...
Source: EPMA Journal - January 8, 2019 Category: International Medicine & Public Health Source Type: research

Stem cells and tooth regeneration: prospects for personalized dentistry
AbstractOver the last several decades, a wealth of information has become available regarding various sources of stem cells and their potential use for regenerative purposes. Given the intense debate regarding embryonic stem cells, much of the focus has centered around application of adult stem cells for regenerative engineering along with other relevant aspects including use of growth factors and scaffolding materials. The more recent discovery of tooth-derived stem cells has sparked much interest in their application to regenerative dentistry to treat and alleviate the most prevalent oral diseases —i.e., dental car...
Source: EPMA Journal - January 7, 2019 Category: International Medicine & Public Health Source Type: research

Biobanks in Horizon 2020: sustainability and attractive perspectives
This article reviews the main Horizon 2020 biobanking projects, financing schemes and the future perspectiv es. (Source: EPMA Journal)
Source: EPMA Journal - November 23, 2018 Category: International Medicine & Public Health Source Type: research

Characteristics of dental patients determining their compliance level in dentistry: relevance for predictive, preventive, and personalized medicine
This article centers on the relationship between psychological specifics of dental patients and their adherence to treatment. It describes clinical and personality specifics of periodontal patients and presents personality characteristics of patients with positive and negative dynamics of the therapy, as well as patients without periodontal diseases. The study findings highlight the importance of building confidential relationships with the patient and the need for a client-oriented approach to developing treatment plans and strategies for different types of dental patients. In the future, based on the study results, we fi...
Source: EPMA Journal - November 13, 2018 Category: International Medicine & Public Health Source Type: research

Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach
AbstractIn contrast to the genetic component in mammary carcinogenesis, epigenetic alterations are particularly important for the development of sporadic breast cancer (BC) comprising over 90% of all BC cases worldwide. Most of the DNA methylation processes are physiological and essential for human cellular and tissue homeostasis, playing an important role in a number of key mechanisms. However, if dysregulated, DNA methylation contributes to pathological processes such as cancer development and progression. A global hypomethylation of oncogenes and hypermethylation of tumor-suppressor genes are characteristic of most canc...
Source: EPMA Journal - November 12, 2018 Category: International Medicine & Public Health Source Type: research

In glaucoma patients, low blood pressure is accompanied by vascular dysregulation
ConclusionsIn glaucoma patients, vascular dysregulation (as defined by response in the nailfold capillaroscopy to a cold provocation) and low BP are statistically related. This is in line with the observation that Flammer syndrome subjects have both primary vascular dysregulation and low BP and that Flammer syndrome is a risk factor for glaucomatous optic neuropathy, at least in normal tension glaucoma patients. The detection of vascular factors in glaucoma patients may lead to a more efficient treatment, better tailored to the individual patient. (Source: EPMA Journal)
Source: EPMA Journal - November 12, 2018 Category: International Medicine & Public Health Source Type: research

The role of the personality traits and work characteristics in the prediction of the burnout syndrome among nurses —a new approach within predictive, preventive, and personalized medicine concept
ConclusionsThis study confirms the influence of the Big Five personality traits and nursing work characteristics as predictive factors of the burnout occurrence, opening real possibilities to perform a targeted prevention and provide personalized interventions as organizational services. (Source: EPMA Journal)
Source: EPMA Journal - October 25, 2018 Category: International Medicine & Public Health Source Type: research

Predictive and individualized management of stroke —success story in Czech Republic
AbstractThe model of centralized stroke care in the Czech Republic was created in 2010 –2012 by Ministry of Health (MH) in cooperation with professional organization—Cerebrovascular Section of the Czech Neurological Society (CSCNS). It defines priorities of stroke care, stroke centers, triage of suspected stroke patients, stroke care quality indicators, their monitoring, and repor ting. Thirteen complex cerebrovascular centers (CCC) provide sophisticated stroke care, including intravenous thrombolysis (IVT), mechanical thrombectomy (MTE), as well as other endovascular (stenting, coiling) and neurosurgical proce...
Source: EPMA Journal - October 25, 2018 Category: International Medicine & Public Health Source Type: research

Radiomics improves efficiency for differentiating subclinical pheochromocytoma from lipid-poor adenoma: a predictive, preventive and personalized medical approach in adrenal incidentalomas
ConclusionsOur radiomic nomograms based on pre-enhanced and enhanced CT images distinguished sPHEO from LPA. In addition, the promising result using  pre-enhanced CT images for predictive diagnostics is important because patients could avoid the additional radiation and risk associated with enhanced CT. (Source: EPMA Journal)
Source: EPMA Journal - September 21, 2018 Category: International Medicine & Public Health Source Type: research

Efficiency of dental caries prevention with the use of polymer-based toothpastes modified by the electromagnetic field
AbstractThe most important problems of modern dentistry cover not only the early diagnosis but also prevention of dental caries, including the one based on the use of various hygienic products and therapeutic agents. Normally, the processes of re- and demineralization in the oral cavity are in a state of dynamic. However, in the presence of cariogenic factors, the balance is shifted towards demineralization. In the event of initial caries, enamel remineralization is possible only to a certain extent, and specifically, for a reversible degree of carious lesion. There was an idea about structural changes in polymer-based con...
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Liquid biopsy and multiparametric analysis in management of liver malignancies: new concepts of the patient stratification and prognostic approach
AbstractBackgroundThe annually recorded incidence of primary hepatic carcinomas has significantly increased over the past two decades accounting for over 800 thousand of annual deaths caused by hepatocellular carcinoma (HCC) alone globally. Further, secondary liver malignancies are much more widespread compared to primary hepatic carcinomas: almost all solid malignancies are able to metastasise into the liver. The primary tumours most frequently metastasising to the liver are breast followed by colorectal carcinomas. Given the increased incidence of both primary and metastatic liver cancers, a new, revised approach is need...
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Current approaches in the clinical management of pregnancy-associated breast cancer —pros and cons
AbstractMalignancies are one of the leading causes of mortality in women during their reproductive life. Treatment of gynecological malignant tumors during pregnancy is possible but not simple, since it creates a conflict between care of the mother and the fetus. BC is the most prevalent malignancy diagnosed in pregnancy, ranking up to 21% of all pregnancy-related malignancies. Due to its stets increasing prevalence, aggressive cancer subtype, and severe ethical and psychological aspects linked to the disease, experts raise an alarm for an acute necessity to improve the overall management of the PABC —the issue which...
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

A new non-invasive diagnostic tool in coronary artery disease: artificial intelligence as an essential element of predictive, preventive, and personalized medicine
ConclusionsThe successful use of the MPA approach has been demonstrated in a broad-risk spectrum of patients undergoing CAD evaluation, as an element of predictive, preventive, personalized medicine, and may be used instead of further non-invasive diagnostic procedures. (Source: EPMA Journal)
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Neuromyelitis optica spectrum disorders and pregnancy: relapse-preventive measures and personalized treatment strategies
This study reviews, on the one hand, the role NMOSD play in fertility, pregnancy complications and pregnancy outcome, and on the other, the effect of pregnancy on NMOSD disease course and treatment options available during pregnancy. Animal studies show lower fertility rates in NMOSD; however, investigations into fertility in NMOSD patients are lacking. Pregnancies in NMOSD patients are associated with increased disease activity and more severe disability postpartum. Some studies found higher risks of pregnancy complications, e.g., miscarriages and preeclampsia. Acute relapses during pregnancy can be treated with methylpre...
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

“Dry mouth” and “Flammer” syndromes—neglected risks in adolescents and new concepts by predictive, preventive and personalised approach
In conclusion, FS questionnaire linked to the “dry mouth” syndrome is strongly recommended for application in primary healthcare. Consequently, targeted preventive measures can be triggered early in life. For example, traditional, complementary and alternative me dicine demonstrates positive therapeutic effects in individuals suffering from xerostomia. For in-depth diagnostics, epi/genetic regulations involved into pathophysiologic mechanisms of hyposalivation in FS-affected individuals should be thoroughly investigated at molecular level. Identified biomark er panels might be of great clinical utility for pred...
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Titanium implants and silent inflammation in jawbone —a critical interplay of dissolved titanium particles and cytokines TNF-α and RANTES/CCL5 on overall health?
ConclusionFrom a systemic perspective, we recommend that more attention be paid to the cytokine cross-talk that is provoked by dissolved Ti particles from DTI in medicine and dentistry. This may contribute to further development of personalized strategies in preventive medicine. (Source: EPMA Journal)
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Biorepository and integrative genomics initiative: designing and implementing a preliminary platform for predictive, preventive and personalized medicine at a pediatric hospital in a historically disadvantaged community in the USA
AbstractCurrent healthcare is evolving to emphasize cost-effective care by leveraging results and outcomes of genomic and other advanced research efforts in clinical care and preventive health planning. Through a collaborative effort between the University of Tennessee Health Science Center (UTHSC) and Le Bonheur Children ’s Hospital (LBCH), the Biorepository and Integrative Genomics (BIG) Initiative was established to set up a pediatric-based DNA biorepository that can serve as a foundation for successful development of delivery platforms for predictive, preventive, and personalized medical services in Memphis, Te n...
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Individualized metabolic profiling stratifies pancreatic and biliary tract cancer: a useful tool for innovative screening programs and predictive strategies in healthcare
This study not only details efficient methods to identify discriminative LMIs for cancer screening but also provides an example of metabolic profiling for distinguishing PC from BTC. Furthermore, the two metabolites [LysoPC(16:0), LysoPC(20:4)] shown to discriminate these diseases are potentially useful when combined with other, previously identified protein or metabolic biomarkers for predictive, preventive and personalized medical approach. (Source: EPMA Journal)
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Latent class analysis to evaluate performance of plasma cortisol, plasma catecholamines, and SHSQ-25 for early recognition of suboptimal health status
ConclusionPlasma cortisol is a valuable biomarker for SHS detection, whereas SHSQ-25 is more suitable for SHS screening in the population-based health survey. The accuracy and applicability of plasma adrenaline are inferior to cortisol and SHSQ-25, respectively. LCA has merit to evaluate performance of plasma cortisol, catecholamines, and SHSQ-25 for recognition of SHS in the absence of a gold standard test. (Source: EPMA Journal)
Source: EPMA Journal - September 1, 2018 Category: International Medicine & Public Health Source Type: research

Suboptimal health status and psychological symptoms among Chinese college students: a perspective of predictive, preventive and personalised health
ConclusionsOur findings confirm that there is a high prevalence of SHS among college students and there is a strong association between SHS and psychological symptoms among Chinese college students. High susceptibility of SHS occurs particularly in vulnerable groups: female students, sophomore students, medical students and students from rural area. Identification of SHS and prompt application of personalised psychological health-supporting activities will promote college students ’ health status. (Source: EPMA Journal)
Source: EPMA Journal - August 28, 2018 Category: International Medicine & Public Health Source Type: research

Liquid biopsy and multiparametric analysis in management of liver malignancies: new concepts of the patient stratification and prognostic approach
AbstractBackgroundThe annually recorded incidence of primary hepatic carcinomas has significantly increased over the past two decades accounting for over 800 thousand of annual deaths caused by hepatocellular carcinoma (HCC) alone globally. Further, secondary liver malignancies are much more widespread compared to primary hepatic carcinomas: almost all solid malignancies are able to metastasise into the liver. The primary tumours most frequently metastasising to the liver are breast followed by colorectal carcinomas. Given the increased incidence of both primary and metastatic liver cancers, a new, revised approach is need...
Source: EPMA Journal - August 17, 2018 Category: International Medicine & Public Health Source Type: research

Individualized metabolic profiling stratifies pancreatic and biliary tract cancer: a useful tool for innovative screening programs and predictive strategies in healthcare
This study not only details efficient methods to identify discriminative LMIs for cancer screening but also provides an example of metabolic profiling for distinguishing PC from BTC. Furthermore, the two metabolites [LysoPC(16:0), LysoPC(20:4)] shown to discriminate these diseases are potentially useful when combined with other, previously identified protein or metabolic biomarkers for predictive, preventive and personalized medical approach. (Source: EPMA Journal)
Source: EPMA Journal - August 17, 2018 Category: International Medicine & Public Health Source Type: research

A new non-invasive diagnostic tool in coronary artery disease: artificial intelligence as an essential element of predictive, preventive, and personalized medicine
ConclusionsThe successful use of the MPA approach has been demonstrated in a broad-risk spectrum of patients undergoing CAD evaluation, as an element of predictive, preventive, personalized medicine, and may be used instead of further non-invasive diagnostic procedures. (Source: EPMA Journal)
Source: EPMA Journal - August 16, 2018 Category: International Medicine & Public Health Source Type: research

Efficiency of dental caries prevention with the use of polymer-based toothpastes modified by the electromagnetic field
AbstractThe most important problems of modern dentistry cover not only the early diagnosis but also prevention of dental caries, including the one based on the use of various hygienic products and therapeutic agents. Normally, the processes of re- and demineralization in the oral cavity are in a state of dynamic. However, in the presence of cariogenic factors, the balance is shifted towards demineralization. In the event of initial caries, enamel remineralization is possible only to a certain extent, and specifically, for a reversible degree of carious lesion. There was an idea about structural changes in polymer-based con...
Source: EPMA Journal - August 14, 2018 Category: International Medicine & Public Health Source Type: research

Neuromyelitis optica spectrum disorders and pregnancy: relapse-preventive measures and personalized treatment strategies
This study reviews, on the one hand, the role NMOSD play in fertility, pregnancy complications and pregnancy outcome, and on the other, the effect of pregnancy on NMOSD disease course and treatment options available during pregnancy. Animal studies show lower fertility rates in NMOSD; however, investigations into fertility in NMOSD patients are lacking. Pregnancies in NMOSD patients are associated with increased disease activity and more severe disability postpartum. Some studies found higher risks of pregnancy complications, e.g., miscarriages and preeclampsia. Acute relapses during pregnancy can be treated with methylpre...
Source: EPMA Journal - August 10, 2018 Category: International Medicine & Public Health Source Type: research

“Dry mouth” and “Flammer” syndromes—neglected risks in adolescents and new concepts by predictive, preventive and personalised approach
In conclusion, FS questionnaire linked to the “dry mouth” syndrome is strongly recommended for application in primary healthcare. Consequently, targeted preventive measures can be triggered early in life. For example, traditional, complementary and alternative me dicine demonstrates positive therapeutic effects in individuals suffering from xerostomia. For in-depth diagnostics, epi/genetic regulations involved into pathophysiologic mechanisms of hyposalivation in FS-affected individuals should be thoroughly investigated at molecular level. Identified biomark er panels might be of great clinical utility for pred...
Source: EPMA Journal - August 2, 2018 Category: International Medicine & Public Health Source Type: research

Biorepository and integrative genomics initiative: designing and implementing a preliminary platform for predictive, preventive and personalized medicine at a pediatric hospital in a historically disadvantaged community in the USA
AbstractCurrent healthcare is evolving to emphasize cost-effective care by leveraging results and outcomes of genomic and other advanced research efforts in clinical care and preventive health planning. Through a collaborative effort between the University of Tennessee Health Science Center (UTHSC) and Le Bonheur Children ’s Hospital (LBCH), the Biorepository and Integrative Genomics (BIG) Initiative was established to set up a pediatric-based DNA biorepository that can serve as a foundation for successful development of delivery platforms for predictive, preventive, and personalized medical services in Memphis, Te n...
Source: EPMA Journal - August 2, 2018 Category: International Medicine & Public Health Source Type: research

Latent class analysis to evaluate performance of plasma cortisol, plasma catecholamines, and SHSQ-25 for early recognition of suboptimal health status
ConclusionPlasma cortisol is a valuable biomarker for SHS detection, whereas SHSQ-25 is more suitable for SHS screening in the population-based health survey. The accuracy and applicability of plasma adrenaline are inferior to cortisol and SHSQ-25, respectively. LCA has merit to evaluate performance of plasma cortisol, catecholamines, and SHSQ-25 for recognition of SHS in the absence of a gold standard test. (Source: EPMA Journal)
Source: EPMA Journal - August 1, 2018 Category: International Medicine & Public Health Source Type: research

Current approaches in the clinical management of pregnancy-associated breast cancer —pros and cons
AbstractMalignancies are one of the leading causes of mortality in women during their reproductive life. Treatment of gynecological malignant tumors during pregnancy is possible but not simple, since it creates a conflict between care of the mother and the fetus. BC is the most prevalent malignancy diagnosed in pregnancy, ranking up to 21% of all pregnancy-related malignancies. Due to its stets increasing prevalence, aggressive cancer subtype, and severe ethical and psychological aspects linked to the disease, experts raise an alarm for an acute necessity to improve the overall management of the PABC —the issue which...
Source: EPMA Journal - June 24, 2018 Category: International Medicine & Public Health Source Type: research

Titanium implants and silent inflammation in jawbone —a critical interplay of dissolved titanium particles and cytokines TNF-α and RANTES/CCL5 on overall health?
ConclusionFrom a systemic perspective, we recommend that more attention be paid to the cytokine cross-talk that is provoked by dissolved Ti particles from DTI in medicine and dentistry. This may contribute to further development of personalized strategies in preventive medicine. (Source: EPMA Journal)
Source: EPMA Journal - June 8, 2018 Category: International Medicine & Public Health Source Type: research

Novel concept to guide systolic heart failure medication by repeated biomarker testing —results from TIME-CHF in context of predictive, preventive, and personalized medicine
ConclusionThe data of this post hoc analysis suggest that decision-making using repeated biomarker measurements may be very promising in bringing treatment of heart failure to a new level in the context of predictive, preventive, and personalized medicine. Clearly, prospective testing is needed before this novel concept can be adopted.Clinical trial registrationisrctn.org, identifier: ISRCTN43596477 (Source: EPMA Journal)
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Premenopausal breast cancer: potential clinical utility of a multi-omics based machine learning approach for patient stratification
AbstractBackgroundThe breast cancer (BC) epidemic is a multifactorial disease attributed to the early twenty-first century: about two million of new cases and half a million deaths are registered annually worldwide. New trends are emerging now: on the one hand, with respect to the geographical BC prevalence and, on the other hand, with respect to the age distribution. Recent statistics demonstrate that young populations are getting more and more affected by BC in both Eastern and Western countries. Therefore, the old rule “the older the age, the higher the BC risk” is getting relativised now. Accumulated eviden...
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Mental stress as consequence and cause of vision loss: the dawn of psychosomatic ophthalmology for preventive and personalized medicine
AbstractThe loss of vision after damage to the retina, optic nerve, or brain has often grave consequences in everyday life such as problems with recognizing faces, reading, or mobility. Because vision loss is considered to be irreversible and often progressive, patients experience continuous mental stress due to worries, anxiety, or fear with secondary consequences such as depression and social isolation. While prolonged mental stress is clearly aconsequence of vision loss, it may also aggravate the situation. In fact, continuous stress and elevated cortisol levels negatively impact the eye and brain due to autonomous nerv...
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Preventive, predictive, and personalized medicine for effective and affordable cancer care
AbstractPreventive, predictive, and personalized medicine (PPPM) has created a wealth of new opportunities but added also new complexities and challenges. The European Cancer Prevention Organization already embraced unanimously molecular biology for primary and secondary prevention. The rapidly exploding genomic language and complexity of methods face oncologists with exponentially growing knowledge they need to assess and apply. Tissue specimen quality becomes one major concern. Some new innovative medicines cost beyond any reasonable threshold of financial support from patients, health care providers, and governments and...
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Specific properties of probiotic strains: relevance and benefits for the host
ConclusionWe recognized strain-dependent properties of studied LAB and bifidobacteria probiotic strains (adhesive ability, resistance to antibiotics, and gut biological fluids) and discussed potential for most effective individualized treatment for gut and distant sites microbiome modulation. (Source: EPMA Journal)
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Pathology-specific molecular profiles of saliva in patients with multiple dental caries —potential application for predictive, preventive and personalised medical services
ConclusionThe detected features in the IR spectra of mixed saliva as well as the calculated changes in the ratios between organic and inorganic components can be used as biomarkers of cariogenesis in the oral cavity, as a diagnostic criterion in the analysis of the oral fluid samples. (Source: EPMA Journal)
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Diabetes care in figures: current pitfalls and future scenario
AbstractDiabetes mellitus (DM) epidemic —on a global scale—is a major and snowballing threat to public health, healthcare systems and economy, due to the cascade of pathologies triggered in a long-term manner after the DM manifestation. There are remarkable differences in the geographic disease spread and acceleration of an increasing DM prevalence recorded. Specifically, the highest initial prevalence of DM was recorded in the Eastern-Mediterranean region in 1980 followed by the highest acceleration of the epidemic characterised by 0.23% of an annual increase resulted in 2.3 times higher prevalence in the year...
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

The influence of mothers ’ oral health behaviour and perception thereof on the dental health of their children
AbstractObjectiveThe study aims to investigate how mothers ’ oral health behaviour and perception thereof influence the dental health in their children.MethodsA total of 556 Vietnamese mother –child pairs participated in the current study. Mothers self-reported their oral status and oral health behaviour and perception. Dental caries of the children were examined using the index of decayed, missing, and filled teeth. The Dental Anxiety Scale instrument was used to assess the dental anx iety level in mothers and children.ResultsAmong mothers, 41.3% had gingival bleeding, 40% perceived their dentition and gingiva...
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Diabetes care in figures: current pitfalls and future scenario
AbstractDiabetes mellitus (DM) epidemic —on a global scale—is a major and snowballing threat to public health, healthcare systems and economy, due to the cascade of pathologies triggered in a long-term manner after the DM manifestation. There are remarkable differences in the geographic disease spread and acceleration of an increasing DM prevalence recorded. Specifically, the highest initial prevalence of DM was recorded in the Eastern-Mediterranean region in 1980 followed by the highest acceleration of the epidemic characterised by 0.23% of an annual increase resulted in 2.3 times higher prevalence in the year...
Source: EPMA Journal - May 22, 2018 Category: International Medicine & Public Health Source Type: research

Novel concept to guide systolic heart failure medication by repeated biomarker testing —results from TIME-CHF in context of predictive, preventive, and personalized medicine
ConclusionThe data of this post hoc analysis suggest that decision-making using repeated biomarker measurements may be very promising in bringing treatment of heart failure to a new level in the context of predictive, preventive, and personalized medicine. Clearly, prospective testing is needed before this novel concept can be adopted.Clinical trial registrationisrctn.org, identifier: ISRCTN43596477 (Source: EPMA Journal)
Source: EPMA Journal - May 13, 2018 Category: International Medicine & Public Health Source Type: research

Mental stress as consequence and cause of vision loss: the dawn of psychosomatic ophthalmology for preventive and personalized medicine
AbstractThe loss of vision after damage to the retina, optic nerve, or brain has often grave consequences in everyday life such as problems with recognizing faces, reading, or mobility. Because vision loss is considered to be irreversible and often progressive, patients experience continuous mental stress due to worries, anxiety, or fear with secondary consequences such as depression and social isolation. While prolonged mental stress is clearly aconsequence of vision loss, it may also aggravate the situation. In fact, continuous stress and elevated cortisol levels negatively impact the eye and brain due to autonomous nerv...
Source: EPMA Journal - May 9, 2018 Category: International Medicine & Public Health Source Type: research

The influence of mothers ’ oral health behaviour and perception thereof on the dental health of their children
AbstractObjectiveThe study aims to investigate how mothers ’ oral health behaviour and perception thereof influence the dental health in their children.MethodsA total of 556 Vietnamese mother –child pairs participated in the current study. Mothers self-reported their oral status and oral health behaviour and perception. Dental caries of the children were examined using the index of decayed, missing, and filled teeth. The Dental Anxiety Scale instrument was used to assess the dental anx iety level in mothers and children.ResultsAmong mothers, 41.3% had gingival bleeding, 40% perceived their dentition and gingiva...
Source: EPMA Journal - April 26, 2018 Category: International Medicine & Public Health Source Type: research

Pathology-specific molecular profiles of saliva in patients with multiple dental caries —potential application for predictive, preventive and personalised medical services
ConclusionThe detected features in the IR spectra of mixed saliva as well as the calculated changes in the ratios between organic and inorganic components can be used as biomarkers of cariogenesis in the oral cavity, as a diagnostic criterion in the analysis of the oral fluid samples. (Source: EPMA Journal)
Source: EPMA Journal - April 25, 2018 Category: International Medicine & Public Health Source Type: research