Endothelial progenitor cells as the target for cardiovascular disease prediction, personalized prevention, and treatments: progressing beyond the state-of-the-art
AbstractStimulated by the leading mortalities of cardiovascular diseases (CVDs), various types of cardiovascular biomaterials have been widely investigated in the past few decades. Although great therapeutic effects can be achieved by bare metal stents (BMS) and drug-eluting stents (DES) within months or years, the long-term complications such as late thrombosis and restenosis have limited their further applications. It is well accepted that rapid endothelialization is a promising approach to eliminate these complications. Convincing evidence has shown that endothelial progenitor cells (EPCs) could be mobilized into the da...
Source: EPMA Journal - September 21, 2020 Category: International Medicine & Public Health Source Type: research

10th Anniversary of the European Association for Predictive, Preventive and Personalised (3P) Medicine  - EPMA World Congress Supplement 2020
AbstractIn 2019, the EPMA celebrated its 10th anniversary at the 5th World Congress in Pilsen, Czech Republic. The history of the International Professional Network dedicated to Predictive, Preventive and Personalised Medicine  (PPPM / 3PM) is rich in achievements. Facing the coronavirus COVID-19 pandemic it is getting evident globally that the predictive approach, targeted prevention and personalisation of medical services is the optimal paradigm in healthcare demonstrating the high potential to save lives and to bene fit the society as a whole. The EPMA World Congress Supplement 2020 highlights advances in...
Source: EPMA Journal - August 19, 2020 Category: International Medicine & Public Health Source Type: research

REM sleep loss –induced elevated noradrenaline could predispose an individual to psychosomatic disorders: a review focused on proposal for prediction, prevention, and personalized treatment
AbstractHistorically and traditionally, it is known that sleep helps in maintaining healthy living. Its duration varies not only among individuals but also in the same individual depending on circumstances, suggesting it is a dynamic and personalized physiological process. It has been divided into rapid eye movement sleep (REMS) and non-REMS (NREMS). The former is unique that adult humans spend the least time in this stage, when although one is physically asleep, the brain behaves as if awake, the dream state. As NREMS is a pre-requisite for appearance of REMS, the latter can be considered a predictive readout of sleep qua...
Source: EPMA Journal - August 13, 2020 Category: International Medicine & Public Health Source Type: research

Integration of quantitative phosphoproteomics and transcriptomics revealed phosphorylation-mediated molecular events as useful tools for a potential patient stratification and personalized treatment of human nonfunctional pituitary adenomas
ConclusionsThis study provided the first large-scale phosphoprotein profiling and phosphorylation-related signaling pathway network alterations in human NFPA tissues. Further, overlapping analysis of phosphoproteins and invasive DEGs revealed the phosphorylation-mediated signaling pathway network changes in invasive NFPAs. These findings are the precious resource for in-depth insight into the molecular mechanisms of NFPAs, as well as for the discovery of effective phosphoprotein biomarkers and therapeutic targets for invasive NFPAs. (Source: EPMA Journal)
Source: EPMA Journal - August 13, 2020 Category: International Medicine & Public Health Source Type: research

Optimal multiparametric set-up modelled for best survival outcomes in palliative treatment of liver malignancies: unsupervised machine learning and 3  PM recommendations
In conclusion, multi-faceted cancer control within the palliative care of liver malig nancies is crucial for improved disease outcomes including individualised patient profiling, predictive models and implementation of corresponding cost-effective risks mitigating measures detailed in the paper. The “proof-of-principle” model is presented. (Source: EPMA Journal)
Source: EPMA Journal - August 10, 2020 Category: International Medicine & Public Health Source Type: research

Insomnia and obstructive sleep apnea as potential triggers of dementia: is personalized prediction and prevention of the pathological cascade applicable?
DiscussionCurrently, the general medical consensus has poorly addressed the role of sleep disorders in exacerbating the risk of dementia. Critically, studies such as the present one emphasizes that the treatment of sleep disorders could be one the preventive measures to evade or to improve dementia symptoms. Additionally, elderly individuals often manifest different sleep deficiency symptoms than younger ones. Given this, an improved age-specific categorization and evaluation methods for sleep deficiency need to be implemented in diagnosing dementia in order to enable personalized assessments and treatments. Collectively, ...
Source: EPMA Journal - July 30, 2020 Category: International Medicine & Public Health Source Type: research

COVID-19 what have we learned? The rise of social machines and connected devices in pandemic management following the concepts of predictive, preventive and personalized medicine
ConclusionInadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping COVID-19 and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. We present a summary of predictive, preventive and personalized digital methods that could be deployed fast to help with the COVID-19 and future pandemics. (Source: EPMA Journal)
Source: EPMA Journal - July 30, 2020 Category: International Medicine & Public Health Source Type: research

Flavonoids against the Warburg phenotype —concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism
AbstractThe Warburg effect is characterised by increased glucose uptake and lactate secretion in cancer cells resulting from metabolic transformation in tumour tissue. The corresponding molecular pathways switch from oxidative phosphorylation to aerobic glycolysis, due to changes in glucose degradation mechanisms known as the ‘Warburg reprogramming’ of cancer cells. Key glycolytic enzymes, glucose transporters and transcription factors involved in the Warburg transformation are frequently dysregulated during carcinogenesis considered as promising diagnostic and prognostic markers as well as treatment targets. F...
Source: EPMA Journal - July 30, 2020 Category: International Medicine & Public Health Source Type: research

Identification of pathology-specific regulators of m 6 A RNA modification to optimize lung cancer management in the context of predictive, preventive, and personalized medicine
ConclusionThis study provided the first view of the pathology-specific regulators of m6A RNA modification in lung cancers and identified the three-m6A-regulator signature (KIAA1429, METTL3, and IGF2BP1) as an independent prognostic model to classify lung cancers into high- and low-risk groups for patient stratification, prognostic assessment, and personalized treatment toward PPPM in lung cancers. (Source: EPMA Journal)
Source: EPMA Journal - July 29, 2020 Category: International Medicine & Public Health Source Type: research

Prostate cancer management: long-term beliefs, epidemic developments in the early twenty-first century and 3PM dimensional solutions
AbstractIn the early twenty-first century, societies around the world are facing the paradoxal epidemic development of PCa as a non-communicable disease. PCa is the most frequently diagnosed cancer for men in several countries such as the USA. Permanently improving diagnostics and treatments in the PCa management causes an impressive divergence between, on one hand, permanently increasing numbers of diagnosed PCa cases and, on the other hand, stable or even slightly decreasing mortality rates. Still, aspects listed below are waiting for innovate solutions in the context of predictive approaches, targeted prevention and per...
Source: EPMA Journal - June 26, 2020 Category: International Medicine & Public Health Source Type: research

Differences in cohort study data affect external validation of artificial intelligence models for predictive diagnostics of dementia - lessons for translation into clinical practice
In conclusion, this study exposes challenges in external validation of AI models on cohort study data and is one of the rare cases in the neurology field in which such external validation was performed. The presented model represents a proof of concept that reliable models for personalized predictive diagnostics are feasible, which, in turn, could lead to adequate disease prevention and hereby enable the PPPM paradigm in the dementia field. (Source: EPMA Journal)
Source: EPMA Journal - June 22, 2020 Category: International Medicine & Public Health Source Type: research

A risk model of prenatal screening markers in first trimester for predicting hypertensive disorders of pregnancy
ConclusionThe use of prenatal screening markers during early pregnancy can identify fetal aneuploidy and can also predict HDPs. The development of innovative screening strategies for gravidas and the targeted prevention of HDPs in high-risk gravidas are essential for perinatal care and early intervention, thus creating significant opportunities for predictive and preventive personalized medicine. In our study, we found that the combination of a series of prenatal screening markers in early pregnancy is better than a single marker; our data clearly demonstrate the diagnostic value of combining PAPP-A, free β-hCG, and N...
Source: EPMA Journal - June 19, 2020 Category: International Medicine & Public Health Source Type: research

Comparative cerebrospinal fluid metabolites profiling in glioma patients to predict malignant transformation and leptomeningeal metastasis with a potential for preventive personalized medicine
In this study, we examined whether cerebrospinal fluid (CSF) metabolome profiles can reflect glioma grade, difference with non-glial tumor, and LM status. We selected 32 CSF samples from glioma patients, and compared them with 10 non-tumor control and seven non-glial brain tumor (medulloblastoma) samples. A total of 10,408 low-mass ions (LMIs) were detected as a candidate of metabolites using mass spectrometry, and representative LMIs were identified via the Human Metabolome Database. Grade IV gliomas showed eight LMIs, including acetic acid, of higher levels (summed sensitivity and specificity> 180%) than grade III gli...
Source: EPMA Journal - June 18, 2020 Category: International Medicine & Public Health Source Type: research

Biobanks in the era of big data: objectives, challenges, perspectives, and innovations for predictive, preventive, and personalised medicine
AbstractBiobanking is entering the new era —era of big data. New technologies, techniques, and knowledge opened the potential of the whole domain of biobanking. Biobanks collect, analyse, store, and share the samples and associated data. Both samples and especially associated data are growing enormously, and new innovative approaches are r equired to handle samples and to utilize the potential of biobanking data. The data reached the quantity and quality of big data, and the scientists are facing the questions how to use them more efficiently, both retrospectively and prospectively with the aim to discover new preven...
Source: EPMA Journal - June 18, 2020 Category: International Medicine & Public Health Source Type: research

Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in  the context of 3P medicine
AbstractSevere durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified pat...
Source: EPMA Journal - May 29, 2020 Category: International Medicine & Public Health Source Type: research

Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes
AbstractRelevanceIvermectin, as an old anti-parasite drug, can suppress almost completely the growth of various human cancers, including ovarian cancer (OC). However, its anticancer mechanism remained to be further studied at the molecular levels. Ivermectin-related molecule-panel changes will serve a useful tool for its personalized drug therapy and prognostic assessment in OCs.PurposeTo explore the functional significance of ivermectin-mediated lncRNA-EIF4A3-mRNA axes in OCs and ivermectin-related molecule-panel for its personalized drug therapy monitoring.MethodsBased on our previous study, a total of 16 lncRNA expressi...
Source: EPMA Journal - May 28, 2020 Category: International Medicine & Public Health Source Type: research

Early decrease in blood platelet count is associated with poor prognosis in COVID-19 patients —indications for predictive, preventive, and personalized medical approach
ConclusionsIn the early stage, platelet count can dynamically reflect the pathophysiological changes in COVID-19 patients. Early decrease in platelet count was associated with mortality in patients with COVID-19. Causality, however, cannot be deduced from our data. (Source: EPMA Journal)
Source: EPMA Journal - May 14, 2020 Category: International Medicine & Public Health Source Type: research

Sleep disorders in migrants and refugees: a systematic review with implications for personalized medical approach
Conclusions and implicationsConsidering the differences in risk factors, vulnerability, and traumatic life events for different migrant populations, origins of sleep difficulties vary, depending on the migrant populations. Effects on sleep disturbances and sleep quality may be a result of integration in the host country, including changes of lifestyle, such as diet and working hours with implication for OSAS (obstructive sleep apnea) and insomnia. Compared with migrant populations, sleep disturbances in refugee populations are more correlated with mental health symptoms and disorders, especially PTSD (post-traumatic stress...
Source: EPMA Journal - May 13, 2020 Category: International Medicine & Public Health Source Type: research

Covid-19 pandemic by the “real-time” monitoring: the Tunisian case and lessons for global epidemics in the context of 3PM strategies
AbstractCovid-19 is neither the first nor the last viral epidemic which societies around the world are, were and will be affected by. Which lessons should be taken from the current pandemic situation? The Covid-19 disease is still not well characterised, and many research teams all over the world are working on prediction of the epidemic scenario, protective measures to populations and sub-populations, therapeutic and vaccination issues, amongst others. Contextually, countries with currently low numbers of Covid-19-infected individuals such as Tunisia are intended to take lessons from those countries which already reached ...
Source: EPMA Journal - April 25, 2020 Category: International Medicine & Public Health Source Type: research

Microbial and metabolomic analysis of gingival crevicular fluid in general chronic periodontitis patients: lessons for a predictive, preventive, and personalized medical approach
This study aimed to analyze the oral microbiome, the oral metabolome, and the link between them and to identify potential molecules as useful biomarkers for predictive, preventive, and personalized medicine (PPPM) in GCP.MethodsIn this study, gingival crevicular fluid (GCF) samples were collected from patients with GCP (n = 30) and healthy controls (n = 28). The abundance of oral microbiota constituents was obtained by Illumina sequencing, and the relative level of metabolites was measured by gas chromatography-mass spectrometry. Full-mouth probing depth, clinical attachment loss, and bleeding o...
Source: EPMA Journal - April 16, 2020 Category: International Medicine & Public Health Source Type: research

Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies
AbstractCannabis-inspired medical products are garnering increasing attention from the scientific community, general public, and health policy makers. A plethora of scientific literature demonstrates intricate engagement of the endocannabinoid system with human immunology, psychology, developmental processes, neuronal plasticity, signal transduction, and metabolic regulation. Despite the therapeutic potential, the adverse psychoactive effects and historical stigma, cannabinoids have limited widespread clinical application. Therefore, it is plausible to weigh carefully the beneficial effects of cannabinoids against the pote...
Source: EPMA Journal - April 15, 2020 Category: International Medicine & Public Health Source Type: research

Personality and stress influence vision restoration and recovery in glaucoma and optic neuropathy following alternating current stimulation: implications for personalized neuromodulation and rehabilitation
ConclusionVision restoration induced by ACS is greater in patients with less stress-prone personality traits and those who show signs of VD. Prospective studies are now needed to determine if personality has (i) acausal influence, i.e., patients with less stress-prone personalities and greater VD signs recover better, and/or (ii) if personality changes are aneffect of the treatment, i.e., successful recovery induces personality changes. Though thecause-effect relationship is still open, we nevertheless propose that psychosocial factors and VD contribute to the highly variable outcome of vision restoration treatments in low...
Source: EPMA Journal - April 13, 2020 Category: International Medicine & Public Health Source Type: research

Original targeted therapy for the management of the burnout syndrome in nurses: an innovative approach and a new opportunity in the context of predictive, preventive and personalized medicine
ConclusionsThe classical psychodrama method can be an effective solution in the prophylaxis and treatment of the burnout syndrome. The multidisciplinary approach according to the PPPM concept including changes of the environmental factors within the professional framework associated with stress control programmes can be promising solutions for the management of this syndrome. (Source: EPMA Journal)
Source: EPMA Journal - April 6, 2020 Category: International Medicine & Public Health Source Type: research

Population-based case-control study revealed metabolomic biomarkers of suboptimal health status in Chinese population —potential utility for innovative approach by predictive, preventive, and personalized medicine
ConclusionPlasma metabolites are valuable biomarkers for SHS identification, and meanwhile, SHSQ-25 can be used as an alternative health screening tool in the population-based health survey. SHS-related metabolic disturbances could be detected at the early onset of SHS, and SHS-related metabolites could create a window opportunity for PPPM of chronic diseases. (Source: EPMA Journal)
Source: EPMA Journal - March 23, 2020 Category: International Medicine & Public Health Source Type: research

Effect of probiotics on obesity-related markers per enterotype: a double-blind, placebo-controlled, randomized clinical trial
ConclusionAdministration of probiotics improved obesity-related markers in obese people, and the efficacy of probiotics differed per gut microbial enterotype and greater responses were observed in thePrevotella-dominant enterotype. (Source: EPMA Journal)
Source: EPMA Journal - February 7, 2020 Category: International Medicine & Public Health Source Type: research

Implementation of artificial intelligence and non-contact infrared thermography for prediction and personalized automatic identification of different stages of cellulite
ConclusionsThe implementation of computer-aided, automatic identification of cellulite severity using infrared imaging is feasible for reliable diagnosis. Such a combination can be used for early diagnosis, as well as monitoring of cellulite progress or therapeutic outcomes in an objective way. IR thermography coupled to AI sets the vision towards their use as an effective tool for complex assessment of cellulite pathogenesis and stratification, which are critical in the implementation of IR thermographic imaging in predictive, preventive, and personalized medicine (PPPM). (Source: EPMA Journal)
Source: EPMA Journal - February 7, 2020 Category: International Medicine & Public Health Source Type: research

Label-free quantitative identification of abnormally ubiquitinated proteins as useful biomarkers for human lung squamous cell carcinomas
ConclusionThese findings revealed ubiquitinomic variations and molecular network alterations in LSCC, which is in combination with multiomics analysis to identify ubiquitination-related biomarkers for in-depth insight into the molecular mechanism and therapeutic targets and for prediction, diagnosis, and prognostic assessment of LSCC. (Source: EPMA Journal)
Source: EPMA Journal - January 4, 2020 Category: International Medicine & Public Health Source Type: research

Evaluation of machine learning methodology for the prediction of healthcare resource utilization and healthcare costs in patients with critical limb ischemia —is preventive and personalized approach on the horizon?
ConclusionsREFS ™ identified baseline predictors of subsequent healthcare resource utilization and costs in CLI patients. Machine learning and model-based, data-driven medicine may complement physicians’ evidence-based medical services. These findings also support the PPPM framework that a paradigm shift from p ost-diagnosis disease care to early management of comorbidities and targeted prevention is warranted to deliver a cost-effective medical services and desirable healthcare economy. (Source: EPMA Journal)
Source: EPMA Journal - January 3, 2020 Category: International Medicine & Public Health Source Type: research

The greater inflammatory pathway —high clinical potential by innovative predictive, preventive, and personalized medical approach
ConclusionsThis shall open to a broader understanding of the causes for WH going awry, offering new operational criteria for patients ’ stratification (prediction and personalization). While this may also offer improved options for targeted prevention, we will envisage new therapeutic strategies to reboot and/or boost WH, to enable its progression across its physiological phases, the first of which is a transient acute inflammat ory response versus the chronic low-grade inflammation characteristic of NCDs. (Source: EPMA Journal)
Source: EPMA Journal - December 10, 2019 Category: International Medicine & Public Health Source Type: research

Abdominal aortic aneurysm in prostate cancer patients: the “road map” from incidental detection to advanced predictive, preventive, and personalized approach utilizing common follow-up for both pathologies
AbstractAbdominal aortic aneurysm (AAA) is often a hidden pathological process showing no clinical symptoms. Genetic burden, smoking, male gender, age> 65 years, and white race have been identified as the main risk factors. A regular screening program has been introduced but is, as yet, unclear and is not performed in most countries. Prostate cancer is the most frequent male malignant disease in Western countries. Prostate cancer is a disease of older age with a median primary diagnosis of over 60 years. In recent years, advanced imaging methods have been established as important diagnostic tools in prostate cancer diag...
Source: EPMA Journal - November 26, 2019 Category: International Medicine & Public Health Source Type: research

Artificial intelligence supported patient self-care in chronic heart failure: a paradigm shift from reactive to predictive, preventive and personalised care
AbstractHeart failure (HF) is one of the most complex chronic disorders with high prevalence, mainly due to the ageing population and better treatment of underlying diseases. Prevalence will continue to rise and is estimated to reach 3% of the population in Western countries by 2025. It is the most important cause of hospitalisation in subjects aged 65 years or more, resulting in high costs and major social impact. The current “one-size-fits-all” approach in the treatment of HF does not result in best outcome for all patients. These facts are an imminent threat to good quality management of patients with HF. An...
Source: EPMA Journal - November 22, 2019 Category: International Medicine & Public Health Source Type: research

Suggestions for improving the design of clinical trials in multiple sclerosis —results of a systematic analysis of completed phase III trials
AbstractThis manuscript reviews the primary and secondary endpoints of pivotal phase III trials with immunomodulatory drugs in multiple sclerosis (MS). Considering the limitations of previous trial designs, we propose new standards for the planning of clinical trials, taking into account latest insights into MS pathophysiology and patient-relevant aspects. Using a systematic overview of published phase III (pivotal) trials performed as part of application for drug market approval, we evaluate the following characteristics: trial duration, number of trial participants, comparators, and endpoints (primary, secondary, magneti...
Source: EPMA Journal - November 22, 2019 Category: International Medicine & Public Health Source Type: research

Vitamin D deficiency and its association with fatigue and quality of life in multiple sclerosis patients
ConclusionThe 90% frequency of multiple sclerosis patients with vitamin D deficiency, together with the significant association of vitamin D status with the absence of fatigue and improved physical and functional well-being, points to vitamin D supplementation as a potential therapy to enhance the patient ’s quality of life.Relevance of the article for predictive, preventive, and personalized medicineThis article emphasizes that vitamin D supplementation can improve clinical outcome in multiple sclerosis patients providing immune modulation and neuroprotection. Identification and correction of vitamin D deficiency ha...
Source: EPMA Journal - November 20, 2019 Category: International Medicine & Public Health Source Type: research

Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles
AbstractA strong relationship exists between tumor and inflammation, which is the hot point in cancer research. Inflammation can promote the occurrence and development of cancer by promoting blood vessel growth, cancer cell proliferation, and tumor invasiveness, negatively regulating immune response, and changing the efficacy of certain anti-tumor drugs. It has been demonstrated that there are a large number of inflammatory factors and inflammatory cells in the tumor microenvironment, and tumor-promoting immunity and anti-tumor immunity exist simultaneously in the tumor microenvironment. The typical relationship between ch...
Source: EPMA Journal - November 20, 2019 Category: International Medicine & Public Health Source Type: research

Development of a membrane lipid metabolism –based signature to predict overall survival for personalized medicine in ccRCC patients
ConclusionOur study might contribute to the optimization of risk stratification for survival and personalized management of ccRCC patients. (Source: EPMA Journal)
Source: EPMA Journal - November 7, 2019 Category: International Medicine & Public Health Source Type: research

Can tailored nanoceria act as a prebiotic? Report on improved lipid profile and gut microbiota in obese mice
ConclusionDietary application of nanoceria combined with probiotic strainsL. casei IMV B-7280,B. animalis VKB, andB. animals VKL has significantly reduced both free and bound cholesterol levels in serum. Simultaneous administration of probiotics and cerium nanoparticles as a prebiotic, in various combinations, significantly enhanced positive individual effects of them on the gut microbiota spectrum. The presented results provide novel insights into mechanisms behind nutritional supplements and open new perspectives for application of probiotics combined with substances demonstrating prebiotic qualities benefiting, therefor...
Source: EPMA Journal - October 29, 2019 Category: International Medicine & Public Health Source Type: research

An examination of colorectal cancer burden by socioeconomic status: evidence from GLOBOCAN 2018
ConclusionColorectal cancer causes a  substantial burden worldwide and exhibit a positive association with the socioeconomic status. With the aid of improving screening modalities, preventable nature of the disease (due to dietary and lifestyle risk factors) and improving treatment procedures, the burden of CRC can largely be curtaile d. The high burden of CRC in developing countries, therefore, calls for effective prevention strategies, cost-effective screening, and early-stage detection, cost-effective predictive, and personalized treatment regime. (Source: EPMA Journal)
Source: EPMA Journal - September 11, 2019 Category: International Medicine & Public Health Source Type: research

Probiotic Lactobacillus and Bifidobacterium strains possess safety characteristics, antiviral activities and host adherence factors revealed by genome mining
ConclusionTaken together, safety privileges, antiviral activities, and genomically encoded host interaction factors confirmed probiotic features of the six probiotic strains and their potential in promoting human health. (Source: EPMA Journal)
Source: EPMA Journal - September 5, 2019 Category: International Medicine & Public Health Source Type: research

Colorectal cancer in Saudi Arabia as the proof-of-principle model for implementing strategies of predictive, preventive, and personalized medicine in healthcare
AbstractColorectal cancer (CRC) is the most commonly diagnosed cancer among Saudi males and ranks third in females with up to 73% of cases diagnosed at late stage. This review provides an analysis of CRC situation in the Kingdom of Saudi Arabia (KSA) from healthcare perspective. A PUBMED (1986 –2018) search was done to identify publications focusing on CRC in KSA. Due to reports of increased CRC incidence among young age group (
Source: EPMA Journal - August 31, 2019 Category: International Medicine & Public Health Source Type: research

TMT-based quantitative proteomics revealed follicle-stimulating hormone (FSH)-related molecular characterizations for potentially prognostic assessment and personalized treatment of FSH-positive non-functional pituitary adenomas
ConclusionsFSH-positive expression was an important NFPA subtype. It was the first time for this study to reveal FSH-related proteomic variations and the corresponding molecular network alterations in FSH-positive relative to negative NFPAs. Also, three signaling pathways (ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathways) and involved upregulated proteins (ITGA1, ITGA6, ITGB4, pAKT, and FSHR) were significantly associated with tumor invasiveness and aggressiveness, and a set of invasiveness-related DEPs were identified with overlapping analysis of 594 DEPs in FSH-positive vs. negative NFPAs and 898...
Source: EPMA Journal - August 29, 2019 Category: International Medicine & Public Health Source Type: research

Flammer syndrome in multiple sclerosis: diagnostics, prediction, and personalization of treatments
ConclusionThis study showed that FS might be associated with MS. Injectable or oral agents are not related to the signs and symptoms of FS. Further studies are needed to validate this association.Relevance of the article for predictive, preventive, and personalized medicineFS is common among MS patients. Being aware of this incidence that might impair the life quality of MS patients is useful to predict the comorbidity and develop preventive strategies and applying personalized treatment options and procedures. (Source: EPMA Journal)
Source: EPMA Journal - August 10, 2019 Category: International Medicine & Public Health Source Type: research

Nomogram prediction for the 3-year risk of type 2 diabetes in healthy mainland China residents
ConclusionOur nomogram can be used as a simple, plausible, affordable, and widely implementable tool to predict a personalized risk of T2DM for Central Chinese residents. The successful identification of at-risk individuals and intervention at an early stage can provide advanced strategies from a predictive, preventive, and personalized medicine perspective. (Source: EPMA Journal)
Source: EPMA Journal - August 6, 2019 Category: International Medicine & Public Health Source Type: research

The potential role of angiopoietin-like protein-8 in type 2 diabetes mellitus: a possibility for predictive diagnosis and targeted preventive measures?
AbstractBackgroundPrevious studies showed altered angiopoietin-like protein-8 (ANGPTL-8) circulating levels in type 2 diabetes mellitus (DM). Whether or not the alteration in ANGPTL-8 level can be a predictive maker for increased DM risk remains unclear.AimInvestigating possible role of ANGPTL-8 as a risk predictor of type2 DM, in addition to a set of factors likely to affect ANGPTL-8 level.MethodsOne hundred recently diagnosed persons with type 2 DM and 100 sex- and age-matched healthy controls were enrolled. Exclusion criteria included type 1 DM, acute infections, history of chronic kidney disease, malignancy, and blood ...
Source: EPMA Journal - August 6, 2019 Category: International Medicine & Public Health Source Type: research

Immunohistological staining of unknown chemokine RANTES/CCL5 expression in jawbone marrow defects —osteoimmunology and disruption of bone remodeling in clinical case studies targeting on predictive preventive personalized medicine
ConclusionR/C may be regarded as an important trigger for possible pathological developments in the fate of hematopoietic stem cells. FDOJ is not a rigidly uniform process but reflects changing stages of development. The absence of correlating findings should not be interpreted as a misdiagnosis. It seems appropriate to direct further research in the field of “maxillo–mandibular osteoimmunology” focusing on R/C overexpression in FDOJ areas. This may contribute to the development of personalized strategies in preventive medicine. (Source: EPMA Journal)
Source: EPMA Journal - August 6, 2019 Category: International Medicine & Public Health Source Type: research

Integration of suboptimal health status evaluation as a criterion for prediction of preeclampsia is strongly recommended for healthcare management in pregnancy: a prospective cohort study in a Ghanaian population
AbstractBackgroundNormotensive pregnancy may develop into preeclampsia (PE) and other adverse pregnancy complications (APCs), for which the causes are still unknown. Suboptimal health status (SHS), a physical state between health and disease, might contribute to the development and progression of PE. By integration of a routine health measure in this Ghanaian Suboptimal Health Cohort Study, we explored the usefulness of a 25-question item SHS questionnaire (SHSQ-25) for early screening and prediction of normotensive pregnant women (NTN-PW) likely to develop PE.MethodsWe assessed the overall health status among a cohort of ...
Source: EPMA Journal - August 5, 2019 Category: International Medicine & Public Health Source Type: research

Inappropriate modeling of chronic and complex disorders: How to reconsider the approach in the context of predictive, preventive and personalized medicine, and translational medicine
This study was therefore undertaken to provide shreds of evidence against the validity of animal models. Limitations of current animal models and drug development strategies based on animal modeling have been systematically discussed. Finally, a variety of potential surrogates have been suggested to change the unfavorable situation in medical research and consequently in healthcare. (Source: EPMA Journal)
Source: EPMA Journal - July 31, 2019 Category: International Medicine & Public Health Source Type: research

Association among resistin, adenylate cyclase-associated protein 1 and high-density lipoprotein cholesterol in patients with colorectal cancer: a multi-marker approach, as a hallmark of innovative predictive, preventive, and personalized medicine
AbstractBackgroundElevated concentrations of resistin have been reported in colorectal cancer (CRC), but its interactions with adenylate cyclase-associated protein 1 (CAP-1) are largely unexplored. We investigated resistin plasma concentration, peripheral blood mononuclear cells (PBMCs) resistin messenger ribonucleic acid (mRNA), and CAP-1 mRNA levels in CRC patients, as well as the impact of resistin gene polymorphism rs1862513 on the examined markers. We also explored associations of resistin with high-density lipoprotein cholesterol (HDL-C) and predictive potential of our parameters for CRC.MethodsEighty-six patients wi...
Source: EPMA Journal - July 20, 2019 Category: International Medicine & Public Health Source Type: research

Targeted therapies for non-HPV-related head and neck cancer: challenges and opportunities in the context of predictive, preventive, and personalized medicine
AbstractHead and neck squamous cell carcinoma (HNSCC) develops in the mucosal lining of the upper aerodigestive tract, principally as a result of exposure to carcinogens present in tobacco products and alcohol, with oncogenic papillomaviruses also being recognized as etiological agents in a limited proportion of cases. As such, there is considerable scope for prevention of disease development and progression. However, despite multimodal approaches to treatment, tumor recurrence and metastatic disease are common problems, and clinical outcome is unsatisfactory. As our understanding of the genetics and biochemical aberration...
Source: EPMA Journal - July 20, 2019 Category: International Medicine & Public Health Source Type: research

Identification of clinical trait –related lncRNA and mRNA biomarkers with weighted gene co-expression network analysis as useful tool for personalized medicine in ovarian cancer
ConclusionThese new findings showed that lncRNA-related networks in OCs are a useful resource for identification of biomarkers in OCs. (Source: EPMA Journal)
Source: EPMA Journal - July 19, 2019 Category: International Medicine & Public Health Source Type: research

The predictive potential of altered spontaneous brain activity patterns in diabetic retinopathy and nephropathy
ConclusionAbnormal spontaneous activity was detected in many areas of the brain, which may provide useful information for understanding the pathology of DRN. Abnormal ALFF values of these brain regions may be of predictive value in the development of early DRN and be a targeted intervention indicator for individualized treatment of diabetic microvascular diseases. (Source: EPMA Journal)
Source: EPMA Journal - July 5, 2019 Category: International Medicine & Public Health Source Type: research