Label-free quantitative identification of abnormally ubiquitinated proteins as useful biomarkers for human lung squamous cell carcinomas
ConclusionThese findings revealed ubiquitinomic variations and molecular network alterations in LSCC, which is in combination with multiomics analysis to identify ubiquitination-related biomarkers for in-depth insight into the molecular mechanism and therapeutic targets and for prediction, diagnosis, and prognostic assessment of LSCC. (Source: EPMA Journal)
Source: EPMA Journal - January 4, 2020 Category: International Medicine & Public Health Source Type: research

Evaluation of machine learning methodology for the prediction of healthcare resource utilization and healthcare costs in patients with critical limb ischemia —is preventive and personalized approach on the horizon?
ConclusionsREFS ™ identified baseline predictors of subsequent healthcare resource utilization and costs in CLI patients. Machine learning and model-based, data-driven medicine may complement physicians’ evidence-based medical services. These findings also support the PPPM framework that a paradigm shift from p ost-diagnosis disease care to early management of comorbidities and targeted prevention is warranted to deliver a cost-effective medical services and desirable healthcare economy. (Source: EPMA Journal)
Source: EPMA Journal - January 3, 2020 Category: International Medicine & Public Health Source Type: research

The greater inflammatory pathway —high clinical potential by innovative predictive, preventive, and personalized medical approach
ConclusionsThis shall open to a broader understanding of the causes for WH going awry, offering new operational criteria for patients ’ stratification (prediction and personalization). While this may also offer improved options for targeted prevention, we will envisage new therapeutic strategies to reboot and/or boost WH, to enable its progression across its physiological phases, the first of which is a transient acute inflammat ory response versus the chronic low-grade inflammation characteristic of NCDs. (Source: EPMA Journal)
Source: EPMA Journal - December 10, 2019 Category: International Medicine & Public Health Source Type: research

Abdominal aortic aneurysm in prostate cancer patients: the “road map” from incidental detection to advanced predictive, preventive, and personalized approach utilizing common follow-up for both pathologies
AbstractAbdominal aortic aneurysm (AAA) is often a hidden pathological process showing no clinical symptoms. Genetic burden, smoking, male gender, age> 65 years, and white race have been identified as the main risk factors. A regular screening program has been introduced but is, as yet, unclear and is not performed in most countries. Prostate cancer is the most frequent male malignant disease in Western countries. Prostate cancer is a disease of older age with a median primary diagnosis of over 60 years. In recent years, advanced imaging methods have been established as important diagnostic tools in prostate cancer diag...
Source: EPMA Journal - November 26, 2019 Category: International Medicine & Public Health Source Type: research

Artificial intelligence supported patient self-care in chronic heart failure: a paradigm shift from reactive to predictive, preventive and personalised care
AbstractHeart failure (HF) is one of the most complex chronic disorders with high prevalence, mainly due to the ageing population and better treatment of underlying diseases. Prevalence will continue to rise and is estimated to reach 3% of the population in Western countries by 2025. It is the most important cause of hospitalisation in subjects aged 65 years or more, resulting in high costs and major social impact. The current “one-size-fits-all” approach in the treatment of HF does not result in best outcome for all patients. These facts are an imminent threat to good quality management of patients with HF. An...
Source: EPMA Journal - November 22, 2019 Category: International Medicine & Public Health Source Type: research

Suggestions for improving the design of clinical trials in multiple sclerosis —results of a systematic analysis of completed phase III trials
AbstractThis manuscript reviews the primary and secondary endpoints of pivotal phase III trials with immunomodulatory drugs in multiple sclerosis (MS). Considering the limitations of previous trial designs, we propose new standards for the planning of clinical trials, taking into account latest insights into MS pathophysiology and patient-relevant aspects. Using a systematic overview of published phase III (pivotal) trials performed as part of application for drug market approval, we evaluate the following characteristics: trial duration, number of trial participants, comparators, and endpoints (primary, secondary, magneti...
Source: EPMA Journal - November 22, 2019 Category: International Medicine & Public Health Source Type: research

Vitamin D deficiency and its association with fatigue and quality of life in multiple sclerosis patients
ConclusionThe 90% frequency of multiple sclerosis patients with vitamin D deficiency, together with the significant association of vitamin D status with the absence of fatigue and improved physical and functional well-being, points to vitamin D supplementation as a potential therapy to enhance the patient ’s quality of life.Relevance of the article for predictive, preventive, and personalized medicineThis article emphasizes that vitamin D supplementation can improve clinical outcome in multiple sclerosis patients providing immune modulation and neuroprotection. Identification and correction of vitamin D deficiency ha...
Source: EPMA Journal - November 20, 2019 Category: International Medicine & Public Health Source Type: research

Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles
AbstractA strong relationship exists between tumor and inflammation, which is the hot point in cancer research. Inflammation can promote the occurrence and development of cancer by promoting blood vessel growth, cancer cell proliferation, and tumor invasiveness, negatively regulating immune response, and changing the efficacy of certain anti-tumor drugs. It has been demonstrated that there are a large number of inflammatory factors and inflammatory cells in the tumor microenvironment, and tumor-promoting immunity and anti-tumor immunity exist simultaneously in the tumor microenvironment. The typical relationship between ch...
Source: EPMA Journal - November 20, 2019 Category: International Medicine & Public Health Source Type: research

Development of a membrane lipid metabolism –based signature to predict overall survival for personalized medicine in ccRCC patients
ConclusionOur study might contribute to the optimization of risk stratification for survival and personalized management of ccRCC patients. (Source: EPMA Journal)
Source: EPMA Journal - November 7, 2019 Category: International Medicine & Public Health Source Type: research

Can tailored nanoceria act as a prebiotic? Report on improved lipid profile and gut microbiota in obese mice
ConclusionDietary application of nanoceria combined with probiotic strainsL. casei IMV B-7280,B. animalis VKB, andB. animals VKL has significantly reduced both free and bound cholesterol levels in serum. Simultaneous administration of probiotics and cerium nanoparticles as a prebiotic, in various combinations, significantly enhanced positive individual effects of them on the gut microbiota spectrum. The presented results provide novel insights into mechanisms behind nutritional supplements and open new perspectives for application of probiotics combined with substances demonstrating prebiotic qualities benefiting, therefor...
Source: EPMA Journal - October 29, 2019 Category: International Medicine & Public Health Source Type: research

An examination of colorectal cancer burden by socioeconomic status: evidence from GLOBOCAN 2018
ConclusionColorectal cancer causes a  substantial burden worldwide and exhibit a positive association with the socioeconomic status. With the aid of improving screening modalities, preventable nature of the disease (due to dietary and lifestyle risk factors) and improving treatment procedures, the burden of CRC can largely be curtaile d. The high burden of CRC in developing countries, therefore, calls for effective prevention strategies, cost-effective screening, and early-stage detection, cost-effective predictive, and personalized treatment regime. (Source: EPMA Journal)
Source: EPMA Journal - September 11, 2019 Category: International Medicine & Public Health Source Type: research

Probiotic Lactobacillus and Bifidobacterium strains possess safety characteristics, antiviral activities and host adherence factors revealed by genome mining
ConclusionTaken together, safety privileges, antiviral activities, and genomically encoded host interaction factors confirmed probiotic features of the six probiotic strains and their potential in promoting human health. (Source: EPMA Journal)
Source: EPMA Journal - September 5, 2019 Category: International Medicine & Public Health Source Type: research

Colorectal cancer in Saudi Arabia as the proof-of-principle model for implementing strategies of predictive, preventive, and personalized medicine in healthcare
AbstractColorectal cancer (CRC) is the most commonly diagnosed cancer among Saudi males and ranks third in females with up to 73% of cases diagnosed at late stage. This review provides an analysis of CRC situation in the Kingdom of Saudi Arabia (KSA) from healthcare perspective. A PUBMED (1986 –2018) search was done to identify publications focusing on CRC in KSA. Due to reports of increased CRC incidence among young age group (
Source: EPMA Journal - August 31, 2019 Category: International Medicine & Public Health Source Type: research

TMT-based quantitative proteomics revealed follicle-stimulating hormone (FSH)-related molecular characterizations for potentially prognostic assessment and personalized treatment of FSH-positive non-functional pituitary adenomas
ConclusionsFSH-positive expression was an important NFPA subtype. It was the first time for this study to reveal FSH-related proteomic variations and the corresponding molecular network alterations in FSH-positive relative to negative NFPAs. Also, three signaling pathways (ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathways) and involved upregulated proteins (ITGA1, ITGA6, ITGB4, pAKT, and FSHR) were significantly associated with tumor invasiveness and aggressiveness, and a set of invasiveness-related DEPs were identified with overlapping analysis of 594 DEPs in FSH-positive vs. negative NFPAs and 898...
Source: EPMA Journal - August 29, 2019 Category: International Medicine & Public Health Source Type: research

Flammer syndrome in multiple sclerosis: diagnostics, prediction, and personalization of treatments
ConclusionThis study showed that FS might be associated with MS. Injectable or oral agents are not related to the signs and symptoms of FS. Further studies are needed to validate this association.Relevance of the article for predictive, preventive, and personalized medicineFS is common among MS patients. Being aware of this incidence that might impair the life quality of MS patients is useful to predict the comorbidity and develop preventive strategies and applying personalized treatment options and procedures. (Source: EPMA Journal)
Source: EPMA Journal - August 10, 2019 Category: International Medicine & Public Health Source Type: research

Nomogram prediction for the 3-year risk of type 2 diabetes in healthy mainland China residents
ConclusionOur nomogram can be used as a simple, plausible, affordable, and widely implementable tool to predict a personalized risk of T2DM for Central Chinese residents. The successful identification of at-risk individuals and intervention at an early stage can provide advanced strategies from a predictive, preventive, and personalized medicine perspective. (Source: EPMA Journal)
Source: EPMA Journal - August 6, 2019 Category: International Medicine & Public Health Source Type: research

The potential role of angiopoietin-like protein-8 in type 2 diabetes mellitus: a possibility for predictive diagnosis and targeted preventive measures?
AbstractBackgroundPrevious studies showed altered angiopoietin-like protein-8 (ANGPTL-8) circulating levels in type 2 diabetes mellitus (DM). Whether or not the alteration in ANGPTL-8 level can be a predictive maker for increased DM risk remains unclear.AimInvestigating possible role of ANGPTL-8 as a risk predictor of type2 DM, in addition to a set of factors likely to affect ANGPTL-8 level.MethodsOne hundred recently diagnosed persons with type 2 DM and 100 sex- and age-matched healthy controls were enrolled. Exclusion criteria included type 1 DM, acute infections, history of chronic kidney disease, malignancy, and blood ...
Source: EPMA Journal - August 6, 2019 Category: International Medicine & Public Health Source Type: research

Immunohistological staining of unknown chemokine RANTES/CCL5 expression in jawbone marrow defects —osteoimmunology and disruption of bone remodeling in clinical case studies targeting on predictive preventive personalized medicine
ConclusionR/C may be regarded as an important trigger for possible pathological developments in the fate of hematopoietic stem cells. FDOJ is not a rigidly uniform process but reflects changing stages of development. The absence of correlating findings should not be interpreted as a misdiagnosis. It seems appropriate to direct further research in the field of “maxillo–mandibular osteoimmunology” focusing on R/C overexpression in FDOJ areas. This may contribute to the development of personalized strategies in preventive medicine. (Source: EPMA Journal)
Source: EPMA Journal - August 6, 2019 Category: International Medicine & Public Health Source Type: research

Integration of suboptimal health status evaluation as a criterion for prediction of preeclampsia is strongly recommended for healthcare management in pregnancy: a prospective cohort study in a Ghanaian population
AbstractBackgroundNormotensive pregnancy may develop into preeclampsia (PE) and other adverse pregnancy complications (APCs), for which the causes are still unknown. Suboptimal health status (SHS), a physical state between health and disease, might contribute to the development and progression of PE. By integration of a routine health measure in this Ghanaian Suboptimal Health Cohort Study, we explored the usefulness of a 25-question item SHS questionnaire (SHSQ-25) for early screening and prediction of normotensive pregnant women (NTN-PW) likely to develop PE.MethodsWe assessed the overall health status among a cohort of ...
Source: EPMA Journal - August 5, 2019 Category: International Medicine & Public Health Source Type: research

Inappropriate modeling of chronic and complex disorders: How to reconsider the approach in the context of predictive, preventive and personalized medicine, and translational medicine
This study was therefore undertaken to provide shreds of evidence against the validity of animal models. Limitations of current animal models and drug development strategies based on animal modeling have been systematically discussed. Finally, a variety of potential surrogates have been suggested to change the unfavorable situation in medical research and consequently in healthcare. (Source: EPMA Journal)
Source: EPMA Journal - July 31, 2019 Category: International Medicine & Public Health Source Type: research

Association among resistin, adenylate cyclase-associated protein 1 and high-density lipoprotein cholesterol in patients with colorectal cancer: a multi-marker approach, as a hallmark of innovative predictive, preventive, and personalized medicine
AbstractBackgroundElevated concentrations of resistin have been reported in colorectal cancer (CRC), but its interactions with adenylate cyclase-associated protein 1 (CAP-1) are largely unexplored. We investigated resistin plasma concentration, peripheral blood mononuclear cells (PBMCs) resistin messenger ribonucleic acid (mRNA), and CAP-1 mRNA levels in CRC patients, as well as the impact of resistin gene polymorphism rs1862513 on the examined markers. We also explored associations of resistin with high-density lipoprotein cholesterol (HDL-C) and predictive potential of our parameters for CRC.MethodsEighty-six patients wi...
Source: EPMA Journal - July 20, 2019 Category: International Medicine & Public Health Source Type: research

Targeted therapies for non-HPV-related head and neck cancer: challenges and opportunities in the context of predictive, preventive, and personalized medicine
AbstractHead and neck squamous cell carcinoma (HNSCC) develops in the mucosal lining of the upper aerodigestive tract, principally as a result of exposure to carcinogens present in tobacco products and alcohol, with oncogenic papillomaviruses also being recognized as etiological agents in a limited proportion of cases. As such, there is considerable scope for prevention of disease development and progression. However, despite multimodal approaches to treatment, tumor recurrence and metastatic disease are common problems, and clinical outcome is unsatisfactory. As our understanding of the genetics and biochemical aberration...
Source: EPMA Journal - July 20, 2019 Category: International Medicine & Public Health Source Type: research

Identification of clinical trait –related lncRNA and mRNA biomarkers with weighted gene co-expression network analysis as useful tool for personalized medicine in ovarian cancer
ConclusionThese new findings showed that lncRNA-related networks in OCs are a useful resource for identification of biomarkers in OCs. (Source: EPMA Journal)
Source: EPMA Journal - July 19, 2019 Category: International Medicine & Public Health Source Type: research

The predictive potential of altered spontaneous brain activity patterns in diabetic retinopathy and nephropathy
ConclusionAbnormal spontaneous activity was detected in many areas of the brain, which may provide useful information for understanding the pathology of DRN. Abnormal ALFF values of these brain regions may be of predictive value in the development of early DRN and be a targeted intervention indicator for individualized treatment of diabetic microvascular diseases. (Source: EPMA Journal)
Source: EPMA Journal - July 5, 2019 Category: International Medicine & Public Health Source Type: research

Relationship between ocular biometry and severity of primary angle-closure glaucoma: relevance for predictive, preventive, and personalized medicine
AbstractBackgroundSeveral ocular factors have been identified for primary angle-closure glaucoma (PACG), such as a small cornea, elevated intraocular pressure (IOP), shallow anterior chamber, and short axial length (AL). However, the relationship between the severity of PACG and various ocular parameters [IOP, anterior chamber depth, AL, central corneal thickness] is not fully understood.MethodsA 7-year cross-sectional study. A total of 2254 eyes of 1312 PACG patients (females  = 856 [1479 eyes] and males = 456 [775 eyes]) were included. A detailed eye examination was performed. The participants...
Source: EPMA Journal - June 11, 2019 Category: International Medicine & Public Health Source Type: research

Signaling pathway network alterations in human ovarian cancers identified with quantitative mitochondrial proteomics
ConclusionThese findings provided the overall signaling pathway network profiling of human OCs; offered scientific data to discover pathway network-based cancer biomarkers for diagnosis, prognosis, and treatment of OCs; and clarify accurate molecular mechanisms and therapeutic targets. These findings benefit for the discovery of effective and reliable biomarkers based on pathway networks for OC predictive and personalized medicine. (Source: EPMA Journal)
Source: EPMA Journal - June 8, 2019 Category: International Medicine & Public Health Source Type: research

Blood biomarker panel recommended for personalized prediction, prognosis, and prevention of complications associated with abdominal aortic aneurysm
AbstractThe aim of the study was to evaluate the ability of following biomarkers as diagnostic tools and risk predictors of AAA: C-reactive protein, interleukin-6, pentraxin-3, galectin-3, procollagen type III N-terminal peptide, C-terminal telopeptide of type I collagen, high-sensitive troponin I, and brain natriuretic peptide. Seventy-two patients with an AAA and 100 healthy individuals were enrolled into the study. We assessed individual biomarker performance and correlation between the AAA diameter and biomarker levels, and also, a multivariate logistic regression was used to design a possible predictive model of AAA g...
Source: EPMA Journal - June 3, 2019 Category: International Medicine & Public Health Source Type: research

Determining health-promoting behavior in smokers preparing to quit: a holistic and personalized approach
ConclusionsSmoking behavior affects especially physical activity and stress management in the study population preparing for smoking cessation. Health-promoting activities in smokers are influenced by occupation as well as dependency levels and smoking habits. Differences exist among white and blue-collar workers in health-promoting behavior. Defining and screening multiple health risk behavior in smokers empower predictive measures and targeted preventive medicine, such as maintaining healthy nutrition and leaving sedentary lifestyle along with efforts to quit smoking. Awareness about health-promoting behavior and thus id...
Source: EPMA Journal - May 25, 2019 Category: International Medicine & Public Health Source Type: research

The burden of prostate cancer is associated with human development index: evidence from 87 countries, 1990 –2016
ConclusionThe high mortality and lower survival rates in less-developed countries demand all-inclusive solutions ranging from cost-effective early screening and detection to cost-effective cancer treatment. In tackling the rising burden of prostate cancer predictive, preventive and personalised medicine (PPPM) can play a useful role through prevention strategies, predicting PCa more precisely and accurately using a multiomic approach and risk-stratifying patients to provide personalised medicine. (Source: EPMA Journal)
Source: EPMA Journal - May 8, 2019 Category: International Medicine & Public Health Source Type: research

Development and validation of nomogram estimating post-surgery hospital stay of lung cancer patients: relevance for predictive, preventive, and personalized healthcare strategies
ConclusionsPreoperative amelioration of RV/TLC may prevent lung cancer patients from unnecessary prolonged p-LOS. The integrated nomogram we developed could provide personalized risk prediction of prolonged p-LOS. This prediction tool may help patients perceive expected hospital stays and enable clinicians to achieve better bed management after lung cancer surgery. (Source: EPMA Journal)
Source: EPMA Journal - May 8, 2019 Category: International Medicine & Public Health Source Type: research

Norwegian drug information centres strongly promote person-centred and personalised medicine: a brief report on the achievements and strategy
AbstractThe Norwegian network of drug information centres (RELIS) has achievements in person-centred and personalised medicine. RELIS receive questions from physicians, pharmacists, nurses and other health professionals and provide decision support in all aspects of pharmacotherapy. Questions associated with person-centred medicine often include problems with unrealistic risk perception and poor adherence among patients. Questions associated with personalised medicine frequently concern comorbidity, biomarkers and pharmacogenetics. The questions frequently include a mix of problems related to health and disease care. The R...
Source: EPMA Journal - April 30, 2019 Category: International Medicine & Public Health Source Type: research

Associations between the red blood cell distribution width and primary angle-closure glaucoma: a potential for disease prediction
AbstractThe red blood cell distribution width (RDW) is a simple and inexpensive laboratory parameter that can be linked to oxidative stress, inflammation and microvascular flow resistance. For this research, we performed a large-sample case-control study to describe the relationships between the RDW and primary angle-closure glaucoma (PACG). A total of 1191 PACG patients (422 males and 769 females), who were divided into mild, moderate and severe PACG groups, and 982 healthy controls (344 males and 638 females) were recruited between January 2008 and June 2018. Detailed eye and physical examinations were performed for each...
Source: EPMA Journal - April 5, 2019 Category: International Medicine & Public Health Source Type: research

Comparisons between protocols and publications of case-control studies: analysis of potential causes of non-reproducibility and recommendations for enhancing the quality of personalization in healthcare
ConclusionThe study protocols should be publicly available prior to the completion of case-control studies so that the potential bias can be assessed by the readers. Our findings highlight the need for investigators, peer reviewers, and readers to exercise increased awareness and scrutiny due to the undesirable practice of selective reporting of results in medical sciences causing the loss of potentially important information, thus impacting quality of personalized attitude in healthcare in the context of the predictive, preventive, and personalized medicine. (Source: EPMA Journal)
Source: EPMA Journal - March 19, 2019 Category: International Medicine & Public Health Source Type: research

Vaginal dryness: individualised patient profiles, risks and mitigating measures
AbstractVaginal dryness (VD) affects both pre- and postmenopausal women at any age. Since the hormonal regulation changes during the climacteric period are  considered as being the main course of the VD, affected women prefer not to talk about the problem. However, the problem does exist, and unfortunately if any, relatively minor group in the population possesses the health literacy at sufficient level to understand that VD is a suboptimal health con dition which carries a multi-factorial character. Thereby, some of the contributing factors are clearly preventable and, therefore, if treated properly, have a potential...
Source: EPMA Journal - March 2, 2019 Category: International Medicine & Public Health Source Type: research

Innate immunity and oral microbiome: a personalized, predictive, and preventive approach to the management of oral diseases
Conclusions and expert recommendations (Source: EPMA Journal)
Source: EPMA Journal - February 25, 2019 Category: International Medicine & Public Health Source Type: research

Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach
AbstractStroke is one of the most devastating pathologies of the early twenty-first century demonstrating 1-month case-fatality rates ranging from 13 to 35% worldwide. Though the majority of cases do occur in individuals at an advanced age, a persistently increasing portion of the patient cohorts is affected early in life. Current studies provide alarming statistics for the incidence of “young” strokes including adolescents. Young stroke is a multifactorial disease involving genetic predisposition but also a number of modifiable factors, the synergic combination of which potentiates the risks. The article analy...
Source: EPMA Journal - February 20, 2019 Category: International Medicine & Public Health Source Type: research

The circadian expression of osteogenic factors in periodontal tissue loading mechanical force: new concepts of the personalized orthodontic care
ConclusionsThis study indicates the existence of a circadian rhythm of the osteogenic factors within the orthodontic sensitive tissues, which highlights the importance of precise timing of force loading in further orthodontic treatment. Thus, a periodicity pattern of orthodontic traction at night may prove a more efficient tooth movement while minimizing the treatment window and discomfort complains. (Source: EPMA Journal)
Source: EPMA Journal - February 18, 2019 Category: International Medicine & Public Health Source Type: research

Suboptimal health status as an independent risk factor for type 2 diabetes mellitus in a community-based cohort: the China suboptimal health cohort study
ConclusionsThe present study suggests that a higher SHS score is associated with a higher incidence of T2DM. SHS is a new independent risk factor for T2DM and has the capability to act as a predictive tool for T2DM onset. The evaluation of SHS combined with the analysis of modifiable risk factors for SHS allows the risk stratification of T2DM, which may consequently contribute to the prevention of T2DM development. These findings might require further validation in a longer-term follow-up study. (Source: EPMA Journal)
Source: EPMA Journal - January 24, 2019 Category: International Medicine & Public Health Source Type: research

Value of pre-operative CTX serum levels in the prediction of medication-related osteonecrosis of the jaw (MRONJ): a retrospective clinical study
ConclusionsSerum levels of CTX by itself are not reliable as a predictive or preventive measure for such complications. Our data also suggested that a drug holiday of 5  months was not helpful in preventing osteonecrosis-related complications in patients on intravenous bisphosphonates. Further studies are urgently needed to develop adequate predictive and preventive strategies of MRONJ. (Source: EPMA Journal)
Source: EPMA Journal - January 24, 2019 Category: International Medicine & Public Health Source Type: research

Oral burning: local and systemic connection for a patient-centric approach
AbstractBurning symptoms in the oral cavity are caused by a range of systemic and local factors, in addition to the neuropathic pain disorder burning mouth syndrome (BMS). Patients may state oral burning as a standalone symptom or may report as a secondary symptom in association with other factors, most commonly with oral dryness, oral mucosal lesions, or certain systemic conditions. There is a level of uncertainty in the presentation of this condition which creates a diagnostic challenge from both the patient ’s perspective and the practitioner evaluating these individuals. The diagnoses are complicated due to the l...
Source: EPMA Journal - January 14, 2019 Category: International Medicine & Public Health Source Type: research

Review of herbal medications with the potential to cause bleeding: dental implications, and risk prediction and prevention avenues
AbstractMedicinal plant products have been used in health care since time immemorial. During the past three decades, the use of herbal supplements has been on the rise in the USA. A number of these products have been shown to possess the potential to interfere with blood clotting. This paper is a review of blood-thinning herbal supplements commonly used in the USA, accompanied by discussion of the dental implications of their use along with suggestions for prediction and prevention of the risk of bleeding. Twenty herbal supplements belonging to four pharmacological groups are identified and reviewed. While the majority (45...
Source: EPMA Journal - January 8, 2019 Category: International Medicine & Public Health Source Type: research

Stem cells and tooth regeneration: prospects for personalized dentistry
AbstractOver the last several decades, a wealth of information has become available regarding various sources of stem cells and their potential use for regenerative purposes. Given the intense debate regarding embryonic stem cells, much of the focus has centered around application of adult stem cells for regenerative engineering along with other relevant aspects including use of growth factors and scaffolding materials. The more recent discovery of tooth-derived stem cells has sparked much interest in their application to regenerative dentistry to treat and alleviate the most prevalent oral diseases —i.e., dental car...
Source: EPMA Journal - January 7, 2019 Category: International Medicine & Public Health Source Type: research

Biobanks in Horizon 2020: sustainability and attractive perspectives
This article reviews the main Horizon 2020 biobanking projects, financing schemes and the future perspectiv es. (Source: EPMA Journal)
Source: EPMA Journal - November 23, 2018 Category: International Medicine & Public Health Source Type: research

Characteristics of dental patients determining their compliance level in dentistry: relevance for predictive, preventive, and personalized medicine
This article centers on the relationship between psychological specifics of dental patients and their adherence to treatment. It describes clinical and personality specifics of periodontal patients and presents personality characteristics of patients with positive and negative dynamics of the therapy, as well as patients without periodontal diseases. The study findings highlight the importance of building confidential relationships with the patient and the need for a client-oriented approach to developing treatment plans and strategies for different types of dental patients. In the future, based on the study results, we fi...
Source: EPMA Journal - November 13, 2018 Category: International Medicine & Public Health Source Type: research

Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach
AbstractIn contrast to the genetic component in mammary carcinogenesis, epigenetic alterations are particularly important for the development of sporadic breast cancer (BC) comprising over 90% of all BC cases worldwide. Most of the DNA methylation processes are physiological and essential for human cellular and tissue homeostasis, playing an important role in a number of key mechanisms. However, if dysregulated, DNA methylation contributes to pathological processes such as cancer development and progression. A global hypomethylation of oncogenes and hypermethylation of tumor-suppressor genes are characteristic of most canc...
Source: EPMA Journal - November 12, 2018 Category: International Medicine & Public Health Source Type: research

In glaucoma patients, low blood pressure is accompanied by vascular dysregulation
ConclusionsIn glaucoma patients, vascular dysregulation (as defined by response in the nailfold capillaroscopy to a cold provocation) and low BP are statistically related. This is in line with the observation that Flammer syndrome subjects have both primary vascular dysregulation and low BP and that Flammer syndrome is a risk factor for glaucomatous optic neuropathy, at least in normal tension glaucoma patients. The detection of vascular factors in glaucoma patients may lead to a more efficient treatment, better tailored to the individual patient. (Source: EPMA Journal)
Source: EPMA Journal - November 12, 2018 Category: International Medicine & Public Health Source Type: research

The role of the personality traits and work characteristics in the prediction of the burnout syndrome among nurses —a new approach within predictive, preventive, and personalized medicine concept
ConclusionsThis study confirms the influence of the Big Five personality traits and nursing work characteristics as predictive factors of the burnout occurrence, opening real possibilities to perform a targeted prevention and provide personalized interventions as organizational services. (Source: EPMA Journal)
Source: EPMA Journal - October 25, 2018 Category: International Medicine & Public Health Source Type: research

Predictive and individualized management of stroke —success story in Czech Republic
AbstractThe model of centralized stroke care in the Czech Republic was created in 2010 –2012 by Ministry of Health (MH) in cooperation with professional organization—Cerebrovascular Section of the Czech Neurological Society (CSCNS). It defines priorities of stroke care, stroke centers, triage of suspected stroke patients, stroke care quality indicators, their monitoring, and repor ting. Thirteen complex cerebrovascular centers (CCC) provide sophisticated stroke care, including intravenous thrombolysis (IVT), mechanical thrombectomy (MTE), as well as other endovascular (stenting, coiling) and neurosurgical proce...
Source: EPMA Journal - October 25, 2018 Category: International Medicine & Public Health Source Type: research

Radiomics improves efficiency for differentiating subclinical pheochromocytoma from lipid-poor adenoma: a predictive, preventive and personalized medical approach in adrenal incidentalomas
ConclusionsOur radiomic nomograms based on pre-enhanced and enhanced CT images distinguished sPHEO from LPA. In addition, the promising result using  pre-enhanced CT images for predictive diagnostics is important because patients could avoid the additional radiation and risk associated with enhanced CT. (Source: EPMA Journal)
Source: EPMA Journal - September 21, 2018 Category: International Medicine & Public Health Source Type: research