Diabetes care in figures: current pitfalls and future scenario
AbstractDiabetes mellitus (DM) epidemic —on a global scale—is a major and snowballing threat to public health, healthcare systems and economy, due to the cascade of pathologies triggered in a long-term manner after the DM manifestation. There are remarkable differences in the geographic disease spread and acceleration of an increasing DM prevalence recorded. Specifically, the highest initial prevalence of DM was recorded in the Eastern-Mediterranean region in 1980 followed by the highest acceleration of the epidemic characterised by 0.23% of an annual increase resulted in 2.3 times higher prevalence in the year...
Source: EPMA Journal - May 22, 2018 Category: International Medicine & Public Health Source Type: research

Novel concept to guide systolic heart failure medication by repeated biomarker testing —results from TIME-CHF in context of predictive, preventive, and personalized medicine
ConclusionThe data of this post hoc analysis suggest that decision-making using repeated biomarker measurements may be very promising in bringing treatment of heart failure to a new level in the context of predictive, preventive, and personalized medicine. Clearly, prospective testing is needed before this novel concept can be adopted.Clinical trial registrationisrctn.org, identifier: ISRCTN43596477 (Source: EPMA Journal)
Source: EPMA Journal - May 13, 2018 Category: International Medicine & Public Health Source Type: research

Mental stress as consequence and cause of vision loss: the dawn of psychosomatic ophthalmology for preventive and personalized medicine
AbstractThe loss of vision after damage to the retina, optic nerve, or brain has often grave consequences in everyday life such as problems with recognizing faces, reading, or mobility. Because vision loss is considered to be irreversible and often progressive, patients experience continuous mental stress due to worries, anxiety, or fear with secondary consequences such as depression and social isolation. While prolonged mental stress is clearly aconsequence of vision loss, it may also aggravate the situation. In fact, continuous stress and elevated cortisol levels negatively impact the eye and brain due to autonomous nerv...
Source: EPMA Journal - May 9, 2018 Category: International Medicine & Public Health Source Type: research

The influence of mothers ’ oral health behaviour and perception thereof on the dental health of their children
AbstractObjectiveThe study aims to investigate how mothers ’ oral health behaviour and perception thereof influence the dental health in their children.MethodsA total of 556 Vietnamese mother –child pairs participated in the current study. Mothers self-reported their oral status and oral health behaviour and perception. Dental caries of the children were examined using the index of decayed, missing, and filled teeth. The Dental Anxiety Scale instrument was used to assess the dental anx iety level in mothers and children.ResultsAmong mothers, 41.3% had gingival bleeding, 40% perceived their dentition and gingiva...
Source: EPMA Journal - April 26, 2018 Category: International Medicine & Public Health Source Type: research

Pathology-specific molecular profiles of saliva in patients with multiple dental caries —potential application for predictive, preventive and personalised medical services
ConclusionThe detected features in the IR spectra of mixed saliva as well as the calculated changes in the ratios between organic and inorganic components can be used as biomarkers of cariogenesis in the oral cavity, as a diagnostic criterion in the analysis of the oral fluid samples. (Source: EPMA Journal)
Source: EPMA Journal - April 25, 2018 Category: International Medicine & Public Health Source Type: research

Specific properties of probiotic strains: relevance and benefits for the host
ConclusionWe recognized strain-dependent properties of studied LAB and bifidobacteria probiotic strains (adhesive ability, resistance to antibiotics, and gut biological fluids) and discussed potential for most effective individualized treatment for gut and distant sites microbiome modulation. (Source: EPMA Journal)
Source: EPMA Journal - April 13, 2018 Category: International Medicine & Public Health Source Type: research

Premenopausal breast cancer: potential clinical utility of a multi-omics based machine learning approach for patient stratification
AbstractBackgroundThe breast cancer (BC) epidemic is a multifactorial disease attributed to the early twenty-first century: about two million of new cases and half a million deaths are registered annually worldwide. New trends are emerging now: on the one hand, with respect to the geographical BC prevalence and, on the other hand, with respect to the age distribution. Recent statistics demonstrate that young populations are getting more and more affected by BC in both Eastern and Western countries. Therefore, the old rule “the older the age, the higher the BC risk” is getting relativised now. Accumulated eviden...
Source: EPMA Journal - April 11, 2018 Category: International Medicine & Public Health Source Type: research

Preventive, predictive, and personalized medicine for effective and affordable cancer care
AbstractPreventive, predictive, and personalized medicine (PPPM) has created a wealth of new opportunities but added also new complexities and challenges. The European Cancer Prevention Organization already embraced unanimously molecular biology for primary and secondary prevention. The rapidly exploding genomic language and complexity of methods face oncologists with exponentially growing knowledge they need to assess and apply. Tissue specimen quality becomes one major concern. Some new innovative medicines cost beyond any reasonable threshold of financial support from patients, health care providers, and governments and...
Source: EPMA Journal - March 26, 2018 Category: International Medicine & Public Health Source Type: research

Heart rate variability: the comparison between high tension and normal tension glaucoma
AbstractRelevanceVascular factors may be involved in the development of both high tension glaucoma (HTG) and normal tension (NTG) glaucoma; however, they may be not exactly the same. Autonomic dysfunction characterized by heart rate variability (HRV) is one of the possible reasons of decrease in mean ocular perfusion pressure (MOPP).PurposeTo compare the shift of the HRV parameters in NTG and HTG patients after a cold provocation test (CPT).MethodsMOPP, 24-hour blood pressure and HRV were studied in 30 NTG, 30 HTG patients, and 28 healthy subjects. The cardiovascular fitness assessment was made before and after the CPT. Th...
Source: EPMA Journal - February 22, 2018 Category: International Medicine & Public Health Source Type: research

Individualised patient profile: clinical utility of Flammer syndrome phenotype and general lessons for predictive, preventive and personalised medicine
AbstractThis case report introduces a female patient, who since her teenager age evidently suffers from Flammer syndrome (FS) as the clearly defined sub-optimal health condition. Further, the patient has experienced collateral pathological conditions which primarily might be linked to the family (genetic) predisposition, but the development of which could be synergistically promoted by the FS-phenotype. The facts are thoroughly analysed and consequent hypotheses are presented, which are indicative for highly desirable predictive diagnostics and targeted preventive measures to be created based on the accurate interpretation...
Source: EPMA Journal - February 22, 2018 Category: International Medicine & Public Health Source Type: research

Clinical and laboratory evaluation of microstructural changes in the physical, mechanical and chemical properties of dental filling materials under the influence of an electromagnetic field
AbstractRestorative filling materials used for dental caries prevention and treatment consist of various components including monomers or oligomers, which play a significant role in forming the main structure of these materials, as well as in characterising their physical, mechanical and chemical properties. The necessity for the development and improvement of structural characteristics of polymeric dental filling materials intended for caries prevention and their life duration increase served as the initiating factor of our research. According to the research purpose and challenges, we studied the changes in the physical,...
Source: EPMA Journal - February 21, 2018 Category: International Medicine & Public Health Source Type: research

The crucial role of multiomic approach in cancer research and clinically relevant outcomes
AbstractCancer with heavily economic and social burden is the hot point in the field of medical research. Some remarkable achievements have been made; however, the exact mechanisms of tumor initiation and development remain unclear. Cancer is a complex, whole-body disease that involves multiple abnormalities in the levels of DNA, RNA, protein, metabolite and medical imaging. Biological omics including genomics, transcriptomics, proteomics, metabolomics and radiomics aims to systematically understand carcinogenesis in different biological levels, which is driving the shift of cancer research paradigm from single parameter m...
Source: EPMA Journal - February 21, 2018 Category: International Medicine & Public Health Source Type: research

Implementation of personalized medicine in Central-Eastern Europe: pitfalls and potentials based on citizen ’s attitude
ConclusionsWe think that given the controversies and complexities of the next-generation sequencing field, the optimal clinical translation of NGS data should be performed in institutions which have the unique capability to provide interprofessional health education, transformative biomedical research, and crucial patient care. With optimization of the clinical translational process, improvement of genetic literacy may increase patient engagement and empowerment.Relevance of the article for predictive, preventive, and personalized medicineThe paper highlights that in countries with relatively low-genetic literacy, a specia...
Source: EPMA Journal - February 9, 2018 Category: International Medicine & Public Health Source Type: research

Pregnancy-associated breast cancer: the risky status quo and new concepts of predictive medicine
AbstractThe paper is motivated by severe concerns regarding currently applied care of the pregnancy-associated breast cancer (PABC) characterised by particularly poor outcomes of the disease. Psychological and ethical aspects play a crucial role in PABC: the highest priority not to damage the foetus significantly complicates any treatment generally, and it is quite usual that patients disclaim undergoing any breast cancer treatment during pregnancy. Although, due to global demographic trends, PABC is far from appearing rarely now, severe societal and economic consequences of the disease are still neglected by currently app...
Source: EPMA Journal - February 8, 2018 Category: International Medicine & Public Health Source Type: research

Optical coherence tomography in neuromyelitis optica spectrum disorders: potential advantages for individualized monitoring of progression and therapy
This article summarizes retinal involvement in NMOSD and reviews OCT methods that could be used now and in the future, for differential diagnosis, for monitoring of disease course, and in clinical trials. (Source: EPMA Journal)
Source: EPMA Journal - December 22, 2017 Category: International Medicine & Public Health Source Type: research

Vitamin D in the prevention, prediction and treatment of neurodegenerative and neuroinflammatory diseases
AbstractVitamin D research has gained increased attention in recent times due to its roles beyond bone health and calcium homeostasis, such as immunomodulation. In some parts of the brain and on immune cells, vitamin D hydroxylating enzymes and its receptors are located. Epidemiological evidence demonstrates that deficiency of Vitamin D is relevant for disease risk and course in multiple sclerosis (MS) and presumably also in neuromyelitis optica spectrum disorders (NMOSD), Parkinson ’s disease (PD), and Alzheimer’s disease (AD). Although the exact mechanism underlying vitamin D effects in these diseases remains...
Source: EPMA Journal - November 15, 2017 Category: International Medicine & Public Health Source Type: research

Incorporation of suboptimal health status as a potential risk assessment for type II diabetes mellitus: a case-control study in a Ghanaian population
AbstractDue to a paradigm shift in lifestyles, there is growing concern that type 2 diabetes mellitus (T2DM) will reach epidemic proportions in Ghana. However, specific characteristics of the disease are under explored in this region. More challenging are those yet to be diagnosed or who complain of poor health in the absence of a diagnosed disease —suboptimal health status (SHS). We conducted a study to examine various factors that characterise SHS and T2DM. Using a cross-sectional design, we recruited 264 people as controls and 241 T2DM patients from January to June 2016. The controls were categorised into high and...
Source: EPMA Journal - October 18, 2017 Category: International Medicine & Public Health Source Type: research

High regenerative capacity of the liver and irreversible injury of male reproductive system in carbon tetrachloride-induced liver fibrosis rat model
AbstractBackgroundLiver fibrosis (LF) is a chronic disease, associated with many collateral diseases including reproductive dysfunction. Although the normal liver has a large regenerative capacity the complications of LF could be severe and irreversible. Hormone and sex-related issues of LF development and interactions with male reproductive have not been finally studied. The aim was to study the reproductive function of male rats in experimental CCl4-induced liver fibrosis rat model, and the capability for restoration of both the liver and male reproduction system.MaterialsStudies were conducted on 20 3-month old Wistar m...
Source: EPMA Journal - October 11, 2017 Category: International Medicine & Public Health Source Type: research

Comparative study of probiotic effects of Lactobacillus and Bifidobacteria strains on cholesterol levels, liver morphology and the gut microbiota in obese mice
ConclusionL. casei IMV B-7280 (separately) and a composition ofB. animalis VKL/B. animalis VKB/L. casei IMV B-7280 are effective at decreasing the weight of obese mice, decreasing cholesterol level, restoring the liver morphology and beneficially modulating the gut microbiome in high-calorie-induced obesity. (Source: EPMA Journal)
Source: EPMA Journal - October 10, 2017 Category: International Medicine & Public Health Source Type: research

Diseases potentially related to Flammer syndrome
AbstractFlammer syndrome (FS) is a prevalent and mostly benign condition. Subjects with FS seem to have a good life expectancy. Nevertheless, FS subjects are at increased risk for certain diseases, mainly when they are challenged by psychological stress or other stimuli such as coldness. FS is related to ocular diseases, such as normal-tension glaucoma, retinitis pigmentosa, central serous chorioretinopathy, optic nerve compartment syndrome, Leber ’s hereditary optic neuropathy, arterial or venous occlusions in the retina, and choroid and optic nerve head, despite the absence of classical vascular risk factors. FS is...
Source: EPMA Journal - September 13, 2017 Category: International Medicine & Public Health Source Type: research

What California sea lions exposed to domoic acid might teach us about autism: lessons for predictive and preventive medicine
AbstractAutism spectrum disorder (ASD) shares many biological and behavioral similarities with the deleterious effects of domoic acid (DA) exposure. DA is produced by marine algae and most commonly by species ofPseudo-nitzschia. Humans and marine mammals can be exposed to DA when they consume whole fish or shellfish. The mammalian fetus is highly sensitive to the deleterious effects of DA exposure. Both ASD and exposures to toxic levels of DA feature repetitive behaviors, challenges with social interaction, and seizures. They can also share a commonality in brain anatomy and function, particularly the balance between excit...
Source: EPMA Journal - September 12, 2017 Category: International Medicine & Public Health Source Type: research

Pharmacogenomics in the treatment of mood disorders: Strategies and Opportunities for personalized psychiatry
AbstractPersonalized medicine (personalized psychiatry in a specific setting) is a new model towards individualized care, in which knowledge from genomics and other omic pillars (microbiome, epigenomes, proteome, and metabolome) will be combined with clinical data to guide efforts to new drug development and targeted prescription of the existing treatment options. In this review, we summarize pharmacogenomic studies in mood disorders that may lay the foundation towards personalized psychiatry. In addition, we have discussed the possible strategies to integrate data from omic pillars as a future path to personalized psychia...
Source: EPMA Journal - September 5, 2017 Category: International Medicine & Public Health Source Type: research

Retinal venous pressure measurements in patients with Flammer syndrome and metabolic syndrome
AbstractBackgroundThe purpose of this research is to analyze retinal venous pressure (RVP) of both eyes of patients who visited a Swiss ophthalmic practice and compare values among the following groups of patients with primary open-angle glaucoma (POAG), Flammer syndrome (FS), and metabolic syndrome (MetS).MethodsRVP was measured in both eyes of all patients who visited a Swiss ophthalmic practice during March 2016 till November 2016, and the results were analyzed retrospectively. All measurements were performed by one physician by means of ophthalmodynamometry. Ophthalmodynamometry is done by applying an increasing pressu...
Source: EPMA Journal - September 5, 2017 Category: International Medicine & Public Health Source Type: research

The BSSG rat model of Parkinson ’s disease: progressing towards a valid, predictive model of disease
AbstractParkinson ’s disease (PD) is a neurodegenerative disorder, classically considered a movement disorder. A great deal is known about the anatomical connections and neuropathology and pharmacological changes of PD, as they relate to the loss of dopaminergic function and the appearance of cardinal motor symptom s. Our understanding of the role of dopamine in PD has led to the development of effective pharmacological treatments of the motor symptoms in the form of dopamine replacement therapy using levodopa and dopaminergic agonists. Much of the information concerning these drug treatments has been obtained using ...
Source: EPMA Journal - September 4, 2017 Category: International Medicine & Public Health Source Type: research

Specific protein biomarker patterns for Alzheimer ’s disease: improved diagnostics in progress
AbstractThis short review looks at Alzheimer ’s disease (AD) diagnosis through my own point of view, going from imaging through cerebrospinal fluid to blood proteins. Over the last couple of years, we have published two papers targeted at Alzheimer’s diagnosis. In one paper, we took an approach of selecting a specific target, namely, activ ity-dependent neuroprotective protein (ADNP), and our results tightened the association of ADNP blood expression with intelligence. In another paper, we took an unbiased approach of analysis of all genes expressed in lymphoblastoid cells lines and discovered changes in expres...
Source: EPMA Journal - September 4, 2017 Category: International Medicine & Public Health Source Type: research

Progressive changes in hippocampal cytoarchitecture in a neurodevelopmental rat model of epilepsy: implications for understanding presymptomatic epileptogenesis, predictive diagnosis, and targeted treatments
AbstractEpilepsies affect about 4% of the population and are frequently characterized by a prolonged “silent” period before the onset of spontaneous seizures. Most current animal models of epilepsy either involve acute seizure induction or kindling protocols that induce repetitive seizures. We have developed a rat model of epilepsy that is characterized by a slowly progressing series of behavio ral abnormalities prior to the onset of behavioral seizures. In the current study, we further describe an accompanying progression of cytoarchitectural changes in the hippocampal formation. Groups of male and female SD r...
Source: EPMA Journal - August 29, 2017 Category: International Medicine & Public Health Source Type: research

Qualitative analysis of Parkinson ’s disease information on social media: the case of YouTube™
ConclusionTo our knowledge, this is the first study to assess the usefulness of PD information on the largest video-sharing website, YouTube ™. In general, the overall quality of information presented in the videos screened was mediocre. Viewership of accurate vs. misleading information was, however, very similar. Therefore, healthcare providers should direct PD patients and their families to the resources that provide reliable and acc urate information. (Source: EPMA Journal)
Source: EPMA Journal - August 23, 2017 Category: International Medicine & Public Health Source Type: research

Emerging issues in public health: a perspective on Ghana ’s healthcare expenditure, policies and outcomes
This study presents an overview of healthcare expenditures and health outcomes (i.e. infant mortali ty, under-5 mortality and life expectancy) from 1995 to 2014 in Ghana. Infant and under-5 mortalities have declined by 50 and 25%, respectively, as of 2014, while life expectancy has increased from 60.7 to 64.8 years. Private spending on health, especially out-of-pocket payments, declined but is hi gher than the World Health Organization’s recommended financial threshold. Non-communicable diseases (NCDs) are rising with healthcare costs leading to catastrophically high healthcare expenditures in the future. While ...
Source: EPMA Journal - August 18, 2017 Category: International Medicine & Public Health Source Type: research

PCSK9 signaling pathways and their potential importance in clinical practice
AbstractIn the following review, authors described the structure and biochemical pathways of PCSK9, its involvement in LDL metabolism, as well as significances of proprotein convertase subtilisin/kexin type 9 targeted treatment. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism. Transcription and translation of PCSK9 is controlled by different nuclear factors, such as, SREBP and HNF1 α. This review focuses on interactions between PCSK9 and LDL receptor, VLDLR, ApoER2, CD36, CD81, and others. The role of PCSK9 in the inflammatory process is presented and its influence on cytokine ...
Source: EPMA Journal - August 14, 2017 Category: International Medicine & Public Health Source Type: research

EPMA World Congress: Traditional Forum in Predictive, Preventive and Personalised Medicine for Multi-Professional Consideration and Consolidation
(Source: EPMA Journal)
Source: EPMA Journal - August 14, 2017 Category: International Medicine & Public Health Source Type: research

The potential relationship between Flammer and Sj ögren syndromes: the chime of dysfunction
AbstractFlammer syndrome (FS) is a term to blanket a cluster of vascular and nonvascular signs and symptoms linked to primary vascular dysregulation (PVD), increased sensitivity to various stimuli (stress, drugs, etc.) and altered sense regulation such as pain, smell and thirst perception. On one hand, disruption of blood barrier and homeostasis of the body are the main targets of vascular irregularity. Inflammation and immune disorders including autoimmunity are considered as a consequence of the abnormal vascular regulation processes. On the other hand, decreased thirst feeling typical for FS-affected individuals may lea...
Source: EPMA Journal - August 14, 2017 Category: International Medicine & Public Health Source Type: research

Diffusion tensor imaging for multilevel assessment of the visual pathway: possibilities for personalized outcome prediction in autoimmune disorders of the central nervous system
AbstractThe afferent visual pathway represents the most frequently affected white matter pathway in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Diffusion tensor imaging (DTI) can reveal microstructural or non-overt brain tissue damage and quantify pathological processes. DTI facilitates the reconstruction of major white matter fiber tracts allowing for the assessment of structure-function and damage-dysfunction relationships. In this review, we outline DTI studies investigating the afferent visual pathway in idiopathic optic neuritis (ON), NMOSD, and MS. Since MS damage patterns are believe...
Source: EPMA Journal - July 25, 2017 Category: International Medicine & Public Health Source Type: research

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?
AbstractAutoimmune diseases, including multiple sclerosis and type 1 diabetes mellitus, affect about 5% of the worldwide population. In the last decade, reports have accumulated on various autoimmune disorders, such as idiopathic thrombocytopenia purpura, myopericarditis, primary ovarian failure, and systemic lupus erythematosus (SLE), following vaccination. In this review, we discuss the possible underlying mechanisms of autoimmune reactions following vaccinations and review cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are reported as possible mechanis...
Source: EPMA Journal - July 20, 2017 Category: International Medicine & Public Health Source Type: research

Perceived social support as a moderator between negative life events and depression in adolescence: implications for prediction and targeted prevention
ConclusionsTaking into account that perceived social support moderates the association between negative stress events and levels of depression, we can propose a model for the prevention of depression, which will include perceived social support. However, future research with longitudinal design is required to verify the results. (Source: EPMA Journal)
Source: EPMA Journal - June 23, 2017 Category: International Medicine & Public Health Source Type: research

Efficacy of Fenugreek-based bionanocomposite on renal dysfunction and endogenous intoxication in high-calorie diet-induced obesity rat model —comparative study
AbstractBackgroundWorldwide obesity spread is a global health problem and needs to be further studied. Co-morbidities of obesity include insulin resistance, diabetes mellitus type 2, and dyslipidemia, which are the most frequent contributing factors for metabolic syndrome (MetS), as well as non-alcoholic fatty liver disease and chronic kidney disease. The aim was to study renal function and endogenous intoxication panel on high-calorie diet-induced obesity rat model and perform comparative study of the treatment efficacy of Fenugreek-based bionanocomposite vs antiobesogenic drugs (Orlistat).MaterialsWe included 60 male rat...
Source: EPMA Journal - June 16, 2017 Category: International Medicine & Public Health Source Type: research

Endothelial dysfunction in cardiovascular disease and Flammer syndrome —similarities and differences
AbstractThe endothelium has increasingly been recognized as a smart barrier and a key regulator of blood flow in micro- and macrovascular beds. Endothelial dysfunction marks a stage of atherosclerosis and is an important prognostic marker for cardiovascular disease. Yet, some people who tend to be slim and physically active and with rather low blood pressure show a propensity to respond to certain stimuli such as emotional stress with endothelial-mediated vascular dysregulation (Flammer syndrome). This leads to characteristic vascular symptoms such as cold hands but also a risk for vascular-mediated diseases such as normal...
Source: EPMA Journal - June 6, 2017 Category: International Medicine & Public Health Source Type: research

Relationship between normal tension glaucoma and Flammer syndrome
ConclusionThere is an association between normal tension glaucoma and Flammer syndrome. If future studies confirm this relationship, treatment of Flammer syndrome may help to prevent normal tension glaucoma or to slow down its progression. (Source: EPMA Journal)
Source: EPMA Journal - June 2, 2017 Category: International Medicine & Public Health Source Type: research

Acupuncture benefits for Flammer syndrome in individuals with inherited diseases of the retina
ConclusionsThe applied acupuncture protocol for FS in IRD patients showed improvement in FS signs and symptoms and was tolerated well. Nevertheless, the objective evaluation of this complementary therapy on FS in IRD patients remains to be elucidated. (Source: EPMA Journal)
Source: EPMA Journal - May 31, 2017 Category: International Medicine & Public Health Source Type: research

Postmenopausal breast cancer: European challenge and innovative concepts
AbstractBreast cancer (BC) epidemic is recognised now worldwide as the reality of the early twenty-first century. Increasing trends in the postmenopausal BC prevalence, even for the European countries earlier demonstrating relatively stable incidence rates of the disease, are highly alarming for the healthcare givers. This new actuality requires a substantial revision of the paradigm currently applied to the BC management and creation of highly innovative concepts. Current multi-centred study highlights new complex mechanisms of the development and progression of the postmenopausal BC. Innovative concepts are presented whi...
Source: EPMA Journal - May 30, 2017 Category: International Medicine & Public Health Source Type: research

Nutritional recommendations for individuals with Flammer syndrome
AbstractThe Flammer syndrome (FS) describes the phenotype of people with a predisposition for an altered reaction of the blood vessels to stimuli like coldness or emotional stress. The question whether such people should be treated is often discussed. On the one hand, most of these subjects are healthy; on the other hand, FS seems to predispose to certain eye diseases such as normal tension glaucoma or retinitis pigmentosa or systemic diseases such as multiple sclerosis or tinnitus. A compromise between doing nothing and a drug treatment is the adaption of nutrition. But what do we mean by healthy food consumption for subj...
Source: EPMA Journal - May 29, 2017 Category: International Medicine & Public Health Source Type: research

The discovery of the Flammer syndrome: a historical and personal perspective
AbstractThis review describes the clinical and basic research that led to the description of Flammer syndrome. It is narrated from a personal perspective. This research was initiated by the observation of an increased long-term fluctuation of visual fields in a subgroup of glaucoma patients. As these patients had strikingly cold hands, peripheral blood flow was tested with a capillary microscopy, and vasospastic syndrome (VS) was diagnosed. Further studies on these patients revealed frequently weakened autoregulation of ocular blood flow and increased flow resistivity in retroocular vessels. Their retinal vessels were more...
Source: EPMA Journal - May 22, 2017 Category: International Medicine & Public Health Source Type: research

Traditional medicine as a potential treatment for Flammer syndrome
(Source: EPMA Journal)
Source: EPMA Journal - May 8, 2017 Category: International Medicine & Public Health Source Type: research

“Pre-metastatic niches” in breast cancer: are they created by or prior to the tumour onset? “Flammer Syndrome” relevance to address the question
AbstractBreast cancer (BC) epidemic in the twenty-first century is characterised by around half a million deaths and 1.7 million new cases registered annually worldwide. Metastatic disease is the major cause of death in BC patient cohorts. Current statistics are much alarming from the viewpoint of the early mortality amongst BC patients with de novo metastatic disease. A new paradigm of so-called “pre-metastatic niches” may sufficiently promote our knowledge regarding potential pathomechanisms, individual predisposition and prognosis in development and progression of the metastatic disease. However, the crucial...
Source: EPMA Journal - May 2, 2017 Category: Global & Universal Source Type: research

Breast cancer and Flammer syndrome: any symptoms in common for prediction, prevention and personalised medical approach?
AbstractAn epidemic scale of the breast cancer (BC) prevalence is actually recognised as the reality of the early twenty-first century. Particularly alarming is that the sporadic BC (about 90% of all patients) creates currently unpredictable subpopulations in terms of disease predisposition, development and progression. Despite broad discussions run since years in BC area, no any plausible approach has been suggested so far to get the overall situation better controlled in the populations. Here, we present highly innovative concepts considering investigation of specific syndromes and symptoms underestimated till now in rel...
Source: EPMA Journal - April 10, 2017 Category: Global & Universal Source Type: research

Current patterns of collaboration in published neurology research
(Source: EPMA Journal)
Source: EPMA Journal - March 22, 2017 Category: Global & Universal Source Type: research

Efficacy of nanoceria for periodontal tissues alteration in glutamate-induced obese rats —multidisciplinary considerations for personalized dentistry and prevention
ConclusionsMSG-induced obesity triggers periodontal tissue alterations in the rat model. Nanoceria contributes to the corrections of pathological changes in periodontal tissues in glutamate-induced obese rats via balancing protein-inhibitory capacity and reducing the depolymerization of fucosylated proteins and proteoglycans and antioxidative activity. (Source: EPMA Journal)
Source: EPMA Journal - March 13, 2017 Category: Global & Universal Source Type: research

Mystery of the brain metastatic disease in breast cancer patients: improved patient stratification, disease prediction and targeted prevention on the horizon?
AbstractThe breast cancer (BC) diagnosis currently experiences the epidemic evolution with more than half of million deaths each year. Despite screening programmes applied and treatments available, breast cancer patients frequently develop distant metastases. The brain is one of the predominant sites of the metastatic spread recorded for more than 20% of BC patients, in contrast to the general population, where brain tumours are rarely diagnosed. Although highly clinically relevant, the brain tumour mystery in the cohort of breast cancer patients has not been yet adequately explained. This review summarises currently avail...
Source: EPMA Journal - March 12, 2017 Category: Global & Universal Source Type: research

Pattern recognition for predictive, preventive, and personalized medicine in cancer
AbstractPredictive, preventive, and personalized medicine (PPPM) is the hot spot and future direction in the field of cancer. Cancer is a complex, whole-body disease that involved multi-factors, multi-processes, and multi-consequences. A series of molecular alterations at different levels of genes (genome), RNAs (transcriptome), proteins (proteome), peptides (peptidome), metabolites (metabolome), and imaging characteristics (radiome) that resulted from exogenous and endogenous carcinogens are involved in tumorigenesis and mutually associate and function in a network system, thus determines the difficulty in the use of a si...
Source: EPMA Journal - March 8, 2017 Category: Global & Universal Source Type: research

Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification?
This article highlights a series of underestimated symptoms for consequent BC risk assessment and patient stratification. Phenomena of the deficient thermoregulation, altered sensitivity to different stimuli (pain, thirst, smell, light, stress provocation), dehydration, altered circadian and sleep patterns, tendency towards headache, migraine attacks and dizziness, as well as local and systemic hypoxic effects are discussed for BC patients providing functional links and proposing new approaches in the overall BC management. (Source: EPMA Journal)
Source: EPMA Journal - March 7, 2017 Category: Global & Universal Source Type: research

Computer-aided surgery meets predictive, preventive, and personalized medicine
We present a brief histor y of CAS, summarize its the state of the art, and discuss current trends and future developments related to PPPM. Of the three Ps, we note that the most important impact of CAS is on Personalization, in all the steps of the surgical treatment: preoperative planning, intraoperative execution, and pos toperative evaluation. Prediction in CAS is reflected in the preoperative evaluation of the various surgical options and in the evaluation of the possible surgical outcomes. Prevention in CAS is related to intraoperative execution, to help prevent possible surgical complications. We foresee that CAS wi...
Source: EPMA Journal - March 6, 2017 Category: Global & Universal Source Type: research