Evaluation of machine learning methodology for the prediction of healthcare resource utilization and healthcare costs in patients with critical limb ischemia —is preventive and personalized approach on the horizon?
ConclusionsREFS ™ identified baseline predictors of subsequent healthcare resource utilization and costs in CLI patients. Machine learning and model-based, data-driven medicine may complement physicians’ evidence-based medical services. These findings also support the PPPM framework that a paradigm shift from p ost-diagnosis disease care to early management of comorbidities and targeted prevention is warranted to deliver a cost-effective medical services and desirable healthcare economy. (Source: EPMA Journal)
Source: EPMA Journal - January 2, 2020 Category: International Medicine & Public Health Source Type: research
The greater inflammatory pathway —high clinical potential by innovative predictive, preventive, and personalized medical approach
ConclusionsThis shall open to a broader understanding of the causes for WH going awry, offering new operational criteria for patients ’ stratification (prediction and personalization). While this may also offer improved options for targeted prevention, we will envisage new therapeutic strategies to reboot and/or boost WH, to enable its progression across its physiological phases, the first of which is a transient acute inflammat ory response versus the chronic low-grade inflammation characteristic of NCDs. (Source: EPMA Journal)
Source: EPMA Journal - December 9, 2019 Category: International Medicine & Public Health Source Type: research
Abdominal aortic aneurysm in prostate cancer patients: the “road map” from incidental detection to advanced predictive, preventive, and personalized approach utilizing common follow-up for both pathologies
AbstractAbdominal aortic aneurysm (AAA) is often a hidden pathological process showing no clinical symptoms. Genetic burden, smoking, male gender, age> 65 years, and white race have been identified as the main risk factors. A regular screening program has been introduced but is, as yet, unclear and is not performed in most countries. Prostate cancer is the most frequent male malignant disease in Western countries. Prostate cancer is a disease of older age with a median primary diagnosis of over 60 years. In recent years, advanced imaging methods have been established as important diagnostic tools in prostate cancer diag...
Source: EPMA Journal - November 25, 2019 Category: International Medicine & Public Health Source Type: research
Artificial intelligence supported patient self-care in chronic heart failure: a paradigm shift from reactive to predictive, preventive and personalised care
AbstractHeart failure (HF) is one of the most complex chronic disorders with high prevalence, mainly due to the ageing population and better treatment of underlying diseases. Prevalence will continue to rise and is estimated to reach 3% of the population in Western countries by 2025. It is the most important cause of hospitalisation in subjects aged 65 years or more, resulting in high costs and major social impact. The current “one-size-fits-all” approach in the treatment of HF does not result in best outcome for all patients. These facts are an imminent threat to good quality management of patients with HF. An unortho...
Source: EPMA Journal - November 21, 2019 Category: International Medicine & Public Health Source Type: research
Suggestions for improving the design of clinical trials in multiple sclerosis —results of a systematic analysis of completed phase III trials
AbstractThis manuscript reviews the primary and secondary endpoints of pivotal phase III trials with immunomodulatory drugs in multiple sclerosis (MS). Considering the limitations of previous trial designs, we propose new standards for the planning of clinical trials, taking into account latest insights into MS pathophysiology and patient-relevant aspects. Using a systematic overview of published phase III (pivotal) trials performed as part of application for drug market approval, we evaluate the following characteristics: trial duration, number of trial participants, comparators, and endpoints (primary, secondary, magneti...
Source: EPMA Journal - November 21, 2019 Category: International Medicine & Public Health Source Type: research
Vitamin D deficiency and its association with fatigue and quality of life in multiple sclerosis patients
ConclusionThe 90% frequency of multiple sclerosis patients with vitamin D deficiency, together with the significant association of vitamin D status with the absence of fatigue and improved physical and functional well-being, points to vitamin D supplementation as a potential therapy to enhance the patient ’s quality of life.Relevance of the article for predictive, preventive, and personalized medicineThis article emphasizes that vitamin D supplementation can improve clinical outcome in multiple sclerosis patients providing immune modulation and neuroprotection. Identification and correction of vitamin D deficiency has th...
Source: EPMA Journal - November 19, 2019 Category: International Medicine & Public Health Source Type: research
Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles
AbstractA strong relationship exists between tumor and inflammation, which is the hot point in cancer research. Inflammation can promote the occurrence and development of cancer by promoting blood vessel growth, cancer cell proliferation, and tumor invasiveness, negatively regulating immune response, and changing the efficacy of certain anti-tumor drugs. It has been demonstrated that there are a large number of inflammatory factors and inflammatory cells in the tumor microenvironment, and tumor-promoting immunity and anti-tumor immunity exist simultaneously in the tumor microenvironment. The typical relationship between ch...
Source: EPMA Journal - November 19, 2019 Category: International Medicine & Public Health Source Type: research
Development of a membrane lipid metabolism –based signature to predict overall survival for personalized medicine in ccRCC patients
ConclusionOur study might contribute to the optimization of risk stratification for survival and personalized management of ccRCC patients. (Source: EPMA Journal)
Source: EPMA Journal - November 6, 2019 Category: International Medicine & Public Health Source Type: research
Can tailored nanoceria act as a prebiotic? Report on improved lipid profile and gut microbiota in obese mice
ConclusionDietary application of nanoceria combined with probiotic strainsL. casei IMV B-7280,B. animalis VKB, andB. animals VKL has significantly reduced both free and bound cholesterol levels in serum. Simultaneous administration of probiotics and cerium nanoparticles as a prebiotic, in various combinations, significantly enhanced positive individual effects of them on the gut microbiota spectrum. The presented results provide novel insights into mechanisms behind nutritional supplements and open new perspectives for application of probiotics combined with substances demonstrating prebiotic qualities benefiting, therefor...
Source: EPMA Journal - October 28, 2019 Category: International Medicine & Public Health Source Type: research
An examination of colorectal cancer burden by socioeconomic status: evidence from GLOBOCAN 2018
ConclusionColorectal cancer causes a substantial burden worldwide and exhibit a positive association with the socioeconomic status. With the aid of improving screening modalities, preventable nature of the disease (due to dietary and lifestyle risk factors) and improving treatment procedures, the burden of CRC can largely be curtaile d. The high burden of CRC in developing countries, therefore, calls for effective prevention strategies, cost-effective screening, and early-stage detection, cost-effective predictive, and personalized treatment regime. (Source: EPMA Journal)
Source: EPMA Journal - September 10, 2019 Category: International Medicine & Public Health Source Type: research
Probiotic Lactobacillus and Bifidobacterium strains possess safety characteristics, antiviral activities and host adherence factors revealed by genome mining
ConclusionTaken together, safety privileges, antiviral activities, and genomically encoded host interaction factors confirmed probiotic features of the six probiotic strains and their potential in promoting human health. (Source: EPMA Journal)
Source: EPMA Journal - September 4, 2019 Category: International Medicine & Public Health Source Type: research
Colorectal cancer in Saudi Arabia as the proof-of-principle model for implementing strategies of predictive, preventive, and personalized medicine in healthcare
AbstractColorectal cancer (CRC) is the most commonly diagnosed cancer among Saudi males and ranks third in females with up to 73% of cases diagnosed at late stage. This review provides an analysis of CRC situation in the Kingdom of Saudi Arabia (KSA) from healthcare perspective. A PUBMED (1986 –2018) search was done to identify publications focusing on CRC in KSA. Due to reports of increased CRC incidence among young age group (< 50), and given the young population of KSA, the disease may burden the national healthcare system in the next decades. Environmental factors attributed to increasing incidence rates of CRC...
Source: EPMA Journal - August 30, 2019 Category: International Medicine & Public Health Source Type: research
TMT-based quantitative proteomics revealed follicle-stimulating hormone (FSH)-related molecular characterizations for potentially prognostic assessment and personalized treatment of FSH-positive non-functional pituitary adenomas
ConclusionsFSH-positive expression was an important NFPA subtype. It was the first time for this study to reveal FSH-related proteomic variations and the corresponding molecular network alterations in FSH-positive relative to negative NFPAs. Also, three signaling pathways (ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathways) and involved upregulated proteins (ITGA1, ITGA6, ITGB4, pAKT, and FSHR) were significantly associated with tumor invasiveness and aggressiveness, and a set of invasiveness-related DEPs were identified with overlapping analysis of 594 DEPs in FSH-positive vs. negative NFPAs and 898...
Source: EPMA Journal - August 28, 2019 Category: International Medicine & Public Health Source Type: research
Flammer syndrome in multiple sclerosis: diagnostics, prediction, and personalization of treatments
ConclusionThis study showed that FS might be associated with MS. Injectable or oral agents are not related to the signs and symptoms of FS. Further studies are needed to validate this association.Relevance of the article for predictive, preventive, and personalized medicineFS is common among MS patients. Being aware of this incidence that might impair the life quality of MS patients is useful to predict the comorbidity and develop preventive strategies and applying personalized treatment options and procedures. (Source: EPMA Journal)
Source: EPMA Journal - August 9, 2019 Category: International Medicine & Public Health Source Type: research
Nomogram prediction for the 3-year risk of type 2 diabetes in healthy mainland China residents
ConclusionOur nomogram can be used as a simple, plausible, affordable, and widely implementable tool to predict a personalized risk of T2DM for Central Chinese residents. The successful identification of at-risk individuals and intervention at an early stage can provide advanced strategies from a predictive, preventive, and personalized medicine perspective. (Source: EPMA Journal)
Source: EPMA Journal - August 5, 2019 Category: International Medicine & Public Health Source Type: research
