The potential role of angiopoietin-like protein-8 in type 2 diabetes mellitus: a possibility for predictive diagnosis and targeted preventive measures?
ConclusionThis study highlights a possible predictive role of ANGPTL-8 in diabetic complications, particularly nephropathy. Larger prognostic studies are needed to validate the cause-effect relationship between ANGPTL-8 and deteriorated kidney functions. (Source: EPMA Journal)
Source: EPMA Journal - August 5, 2019 Category: International Medicine & Public Health Source Type: research
Immunohistological staining of unknown chemokine RANTES/CCL5 expression in jawbone marrow defects —osteoimmunology and disruption of bone remodeling in clinical case studies targeting on predictive preventive personalized medicine
ConclusionR/C may be regarded as an important trigger for possible pathological developments in the fate of hematopoietic stem cells. FDOJ is not a rigidly uniform process but reflects changing stages of development. The absence of correlating findings should not be interpreted as a misdiagnosis. It seems appropriate to direct further research in the field of “maxillo–mandibular osteoimmunology” focusing on R/C overexpression in FDOJ areas. This may contribute to the development of personalized strategies in preventive medicine. (Source: EPMA Journal)
Source: EPMA Journal - August 5, 2019 Category: International Medicine & Public Health Source Type: research
Integration of suboptimal health status evaluation as a criterion for prediction of preeclampsia is strongly recommended for healthcare management in pregnancy: a prospective cohort study in a Ghanaian population
ConclusionsHigh SHS score is associated with increased incidence of PE; hence, SHSQ-25 can be used independently as a risk stratification tool for adverse pregnancy outcomes thereby creating an opportunity for predictive, preventive and personalized medicine. (Source: EPMA Journal)
Source: EPMA Journal - August 4, 2019 Category: International Medicine & Public Health Source Type: research
Inappropriate modeling of chronic and complex disorders: How to reconsider the approach in the context of predictive, preventive and personalized medicine, and translational medicine
This study was therefore undertaken to provide shreds of evidence against the validity of animal models. Limitations of current animal models and drug development strategies based on animal modeling have been systematically discussed. Finally, a variety of potential surrogates have been suggested to change the unfavorable situation in medical research and consequently in healthcare. (Source: EPMA Journal)
Source: EPMA Journal - July 30, 2019 Category: International Medicine & Public Health Source Type: research
Association among resistin, adenylate cyclase-associated protein 1 and high-density lipoprotein cholesterol in patients with colorectal cancer: a multi-marker approach, as a hallmark of innovative predictive, preventive, and personalized medicine
ConclusionsOur study demonstrated increased plasma resistin and CAP-1 mRNA levels, implying their possible interaction in CRC. The association among plasma resistin and HDL-C might indicate that HDL-C is involved in alterations of resistin ’s secretion process. As a hallmark of personalized medicine, multi-marker approach in determination of resistin-related parameters might be useful for prediction and prevention of CRC development. (Source: EPMA Journal)
Source: EPMA Journal - July 19, 2019 Category: International Medicine & Public Health Source Type: research
Targeted therapies for non-HPV-related head and neck cancer: challenges and opportunities in the context of predictive, preventive, and personalized medicine
AbstractHead and neck squamous cell carcinoma (HNSCC) develops in the mucosal lining of the upper aerodigestive tract, principally as a result of exposure to carcinogens present in tobacco products and alcohol, with oncogenic papillomaviruses also being recognized as etiological agents in a limited proportion of cases. As such, there is considerable scope for prevention of disease development and progression. However, despite multimodal approaches to treatment, tumor recurrence and metastatic disease are common problems, and clinical outcome is unsatisfactory. As our understanding of the genetics and biochemical aberration...
Source: EPMA Journal - July 19, 2019 Category: International Medicine & Public Health Source Type: research
Identification of clinical trait –related lncRNA and mRNA biomarkers with weighted gene co-expression network analysis as useful tool for personalized medicine in ovarian cancer
ConclusionThese new findings showed that lncRNA-related networks in OCs are a useful resource for identification of biomarkers in OCs. (Source: EPMA Journal)
Source: EPMA Journal - July 18, 2019 Category: International Medicine & Public Health Source Type: research
The predictive potential of altered spontaneous brain activity patterns in diabetic retinopathy and nephropathy
ConclusionAbnormal spontaneous activity was detected in many areas of the brain, which may provide useful information for understanding the pathology of DRN. Abnormal ALFF values of these brain regions may be of predictive value in the development of early DRN and be a targeted intervention indicator for individualized treatment of diabetic microvascular diseases. (Source: EPMA Journal)
Source: EPMA Journal - July 4, 2019 Category: International Medicine & Public Health Source Type: research
Relationship between ocular biometry and severity of primary angle-closure glaucoma: relevance for predictive, preventive, and personalized medicine
ConclusionsThe AL was positively and significantly related to the severity of PACG in female but not male subjects. This finding refers to the PACG pathogenesis and suggests the use of AL assessment in glaucoma monitoring, diagnosis, and progression. This may contribute to further development of personalized strategies in preventive medicine. (Source: EPMA Journal)
Source: EPMA Journal - June 10, 2019 Category: International Medicine & Public Health Source Type: research
Signaling pathway network alterations in human ovarian cancers identified with quantitative mitochondrial proteomics
ConclusionThese findings provided the overall signaling pathway network profiling of human OCs; offered scientific data to discover pathway network-based cancer biomarkers for diagnosis, prognosis, and treatment of OCs; and clarify accurate molecular mechanisms and therapeutic targets. These findings benefit for the discovery of effective and reliable biomarkers based on pathway networks for OC predictive and personalized medicine. (Source: EPMA Journal)
Source: EPMA Journal - June 7, 2019 Category: International Medicine & Public Health Source Type: research
Blood biomarker panel recommended for personalized prediction, prognosis, and prevention of complications associated with abdominal aortic aneurysm
AbstractThe aim of the study was to evaluate the ability of following biomarkers as diagnostic tools and risk predictors of AAA: C-reactive protein, interleukin-6, pentraxin-3, galectin-3, procollagen type III N-terminal peptide, C-terminal telopeptide of type I collagen, high-sensitive troponin I, and brain natriuretic peptide. Seventy-two patients with an AAA and 100 healthy individuals were enrolled into the study. We assessed individual biomarker performance and correlation between the AAA diameter and biomarker levels, and also, a multivariate logistic regression was used to design a possible predictive model of AAA g...
Source: EPMA Journal - June 2, 2019 Category: International Medicine & Public Health Source Type: research
Determining health-promoting behavior in smokers preparing to quit: a holistic and personalized approach
ConclusionsSmoking behavior affects especially physical activity and stress management in the study population preparing for smoking cessation. Health-promoting activities in smokers are influenced by occupation as well as dependency levels and smoking habits. Differences exist among white and blue-collar workers in health-promoting behavior. Defining and screening multiple health risk behavior in smokers empower predictive measures and targeted preventive medicine, such as maintaining healthy nutrition and leaving sedentary lifestyle along with efforts to quit smoking. Awareness about health-promoting behavior and thus id...
Source: EPMA Journal - May 24, 2019 Category: International Medicine & Public Health Source Type: research
The burden of prostate cancer is associated with human development index: evidence from 87 countries, 1990 –2016
ConclusionThe high mortality and lower survival rates in less-developed countries demand all-inclusive solutions ranging from cost-effective early screening and detection to cost-effective cancer treatment. In tackling the rising burden of prostate cancer predictive, preventive and personalised medicine (PPPM) can play a useful role through prevention strategies, predicting PCa more precisely and accurately using a multiomic approach and risk-stratifying patients to provide personalised medicine. (Source: EPMA Journal)
Source: EPMA Journal - May 7, 2019 Category: International Medicine & Public Health Source Type: research
Development and validation of nomogram estimating post-surgery hospital stay of lung cancer patients: relevance for predictive, preventive, and personalized healthcare strategies
ConclusionsPreoperative amelioration of RV/TLC may prevent lung cancer patients from unnecessary prolonged p-LOS. The integrated nomogram we developed could provide personalized risk prediction of prolonged p-LOS. This prediction tool may help patients perceive expected hospital stays and enable clinicians to achieve better bed management after lung cancer surgery. (Source: EPMA Journal)
Source: EPMA Journal - May 7, 2019 Category: International Medicine & Public Health Source Type: research
Norwegian drug information centres strongly promote person-centred and personalised medicine: a brief report on the achievements and strategy
AbstractThe Norwegian network of drug information centres (RELIS) has achievements in person-centred and personalised medicine. RELIS receive questions from physicians, pharmacists, nurses and other health professionals and provide decision support in all aspects of pharmacotherapy. Questions associated with person-centred medicine often include problems with unrealistic risk perception and poor adherence among patients. Questions associated with personalised medicine frequently concern comorbidity, biomarkers and pharmacogenetics. The questions frequently include a mix of problems related to health and disease care. The R...
Source: EPMA Journal - April 29, 2019 Category: International Medicine & Public Health Source Type: research
