Comparative cerebrospinal fluid metabolites profiling in glioma patients to predict malignant transformation and leptomeningeal metastasis with a potential for preventive personalized medicine
In this study, we examined whether cerebrospinal fluid (CSF) metabolome profiles can reflect glioma grade, difference with non-glial tumor, and LM status. We selected 32 CSF samples from glioma patients, and compared them with 10 non-tumor control and seven non-glial brain tumor (medulloblastoma) samples. A total of 10,408 low-mass ions (LMIs) were detected as a candidate of metabolites using mass spectrometry, and representative LMIs were identified via the Human Metabolome Database. Grade IV gliomas showed eight LMIs, including acetic acid, of higher levels (summed sensitivity and specificity> 180%) than grade III gli...
Source: EPMA Journal - June 17, 2020 Category: International Medicine & Public Health Source Type: research
Biobanks in the era of big data: objectives, challenges, perspectives, and innovations for predictive, preventive, and personalised medicine
AbstractBiobanking is entering the new era —era of big data. New technologies, techniques, and knowledge opened the potential of the whole domain of biobanking. Biobanks collect, analyse, store, and share the samples and associated data. Both samples and especially associated data are growing enormously, and new innovative approaches are r equired to handle samples and to utilize the potential of biobanking data. The data reached the quantity and quality of big data, and the scientists are facing the questions how to use them more efficiently, both retrospectively and prospectively with the aim to discover new preventive...
Source: EPMA Journal - June 17, 2020 Category: International Medicine & Public Health Source Type: research
Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine
AbstractSevere durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified pat...
Source: EPMA Journal - May 28, 2020 Category: International Medicine & Public Health Source Type: research
Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes
ConclusionThose findings provided the potential targeted lncRNA-EIF4A3-mRNA pathways of ivermectin in OC, and constructed the effective prognostic model, which benefits discovery of novel mechanism of ivermectin to suppress ovarian cancer cells, and the ivermectin-related molecule-panel changes benefit for its personalized drug therapy and prognostic assessment towards its predictive, preventive, and personalized medicine (PPPM) in OCs. (Source: EPMA Journal)
Source: EPMA Journal - May 27, 2020 Category: International Medicine & Public Health Source Type: research
Early decrease in blood platelet count is associated with poor prognosis in COVID-19 patients —indications for predictive, preventive, and personalized medical approach
ConclusionsIn the early stage, platelet count can dynamically reflect the pathophysiological changes in COVID-19 patients. Early decrease in platelet count was associated with mortality in patients with COVID-19. Causality, however, cannot be deduced from our data. (Source: EPMA Journal)
Source: EPMA Journal - May 13, 2020 Category: International Medicine & Public Health Source Type: research
Sleep disorders in migrants and refugees: a systematic review with implications for personalized medical approach
Conclusions and implicationsConsidering the differences in risk factors, vulnerability, and traumatic life events for different migrant populations, origins of sleep difficulties vary, depending on the migrant populations. Effects on sleep disturbances and sleep quality may be a result of integration in the host country, including changes of lifestyle, such as diet and working hours with implication for OSAS (obstructive sleep apnea) and insomnia. Compared with migrant populations, sleep disturbances in refugee populations are more correlated with mental health symptoms and disorders, especially PTSD (post-traumatic stress...
Source: EPMA Journal - May 12, 2020 Category: International Medicine & Public Health Source Type: research
Covid-19 pandemic by the “real-time” monitoring: the Tunisian case and lessons for global epidemics in the context of 3PM strategies
AbstractCovid-19 is neither the first nor the last viral epidemic which societies around the world are, were and will be affected by. Which lessons should be taken from the current pandemic situation? The Covid-19 disease is still not well characterised, and many research teams all over the world are working on prediction of the epidemic scenario, protective measures to populations and sub-populations, therapeutic and vaccination issues, amongst others. Contextually, countries with currently low numbers of Covid-19-infected individuals such as Tunisia are intended to take lessons from those countries which already reached ...
Source: EPMA Journal - April 24, 2020 Category: International Medicine & Public Health Source Type: research
Microbial and metabolomic analysis of gingival crevicular fluid in general chronic periodontitis patients: lessons for a predictive, preventive, and personalized medical approach
ConclusionsDysbiosis in the polymicrobial community structure and changes in metabolism could be mechanisms underlying periodontitis. The differential microorganisms and metabolites in GCF between periodontitis patients and healthy individuals are possibly biomarkers, pointing to a potential strategy for the prediction, diagnosis, prognosis, and management of personalized periodontal therapy. (Source: EPMA Journal)
Source: EPMA Journal - April 15, 2020 Category: International Medicine & Public Health Source Type: research
Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies
AbstractCannabis-inspired medical products are garnering increasing attention from the scientific community, general public, and health policy makers. A plethora of scientific literature demonstrates intricate engagement of the endocannabinoid system with human immunology, psychology, developmental processes, neuronal plasticity, signal transduction, and metabolic regulation. Despite the therapeutic potential, the adverse psychoactive effects and historical stigma, cannabinoids have limited widespread clinical application. Therefore, it is plausible to weigh carefully the beneficial effects of cannabinoids against the pote...
Source: EPMA Journal - April 14, 2020 Category: International Medicine & Public Health Source Type: research
Personality and stress influence vision restoration and recovery in glaucoma and optic neuropathy following alternating current stimulation: implications for personalized neuromodulation and rehabilitation
ConclusionVision restoration induced by ACS is greater in patients with less stress-prone personality traits and those who show signs of VD. Prospective studies are now needed to determine if personality has (i) acausal influence, i.e., patients with less stress-prone personalities and greater VD signs recover better, and/or (ii) if personality changes are aneffect of the treatment, i.e., successful recovery induces personality changes. Though thecause-effect relationship is still open, we nevertheless propose that psychosocial factors and VD contribute to the highly variable outcome of vision restoration treatments in low...
Source: EPMA Journal - April 12, 2020 Category: International Medicine & Public Health Source Type: research
Original targeted therapy for the management of the burnout syndrome in nurses: an innovative approach and a new opportunity in the context of predictive, preventive and personalized medicine
ConclusionsThe classical psychodrama method can be an effective solution in the prophylaxis and treatment of the burnout syndrome. The multidisciplinary approach according to the PPPM concept including changes of the environmental factors within the professional framework associated with stress control programmes can be promising solutions for the management of this syndrome. (Source: EPMA Journal)
Source: EPMA Journal - April 5, 2020 Category: International Medicine & Public Health Source Type: research
Population-based case-control study revealed metabolomic biomarkers of suboptimal health status in Chinese population —potential utility for innovative approach by predictive, preventive, and personalized medicine
ConclusionPlasma metabolites are valuable biomarkers for SHS identification, and meanwhile, SHSQ-25 can be used as an alternative health screening tool in the population-based health survey. SHS-related metabolic disturbances could be detected at the early onset of SHS, and SHS-related metabolites could create a window opportunity for PPPM of chronic diseases. (Source: EPMA Journal)
Source: EPMA Journal - March 22, 2020 Category: International Medicine & Public Health Source Type: research
Effect of probiotics on obesity-related markers per enterotype: a double-blind, placebo-controlled, randomized clinical trial
ConclusionAdministration of probiotics improved obesity-related markers in obese people, and the efficacy of probiotics differed per gut microbial enterotype and greater responses were observed in thePrevotella-dominant enterotype. (Source: EPMA Journal)
Source: EPMA Journal - February 6, 2020 Category: International Medicine & Public Health Source Type: research
Implementation of artificial intelligence and non-contact infrared thermography for prediction and personalized automatic identification of different stages of cellulite
ConclusionsThe implementation of computer-aided, automatic identification of cellulite severity using infrared imaging is feasible for reliable diagnosis. Such a combination can be used for early diagnosis, as well as monitoring of cellulite progress or therapeutic outcomes in an objective way. IR thermography coupled to AI sets the vision towards their use as an effective tool for complex assessment of cellulite pathogenesis and stratification, which are critical in the implementation of IR thermographic imaging in predictive, preventive, and personalized medicine (PPPM). (Source: EPMA Journal)
Source: EPMA Journal - February 6, 2020 Category: International Medicine & Public Health Source Type: research
Label-free quantitative identification of abnormally ubiquitinated proteins as useful biomarkers for human lung squamous cell carcinomas
ConclusionThese findings revealed ubiquitinomic variations and molecular network alterations in LSCC, which is in combination with multiomics analysis to identify ubiquitination-related biomarkers for in-depth insight into the molecular mechanism and therapeutic targets and for prediction, diagnosis, and prognostic assessment of LSCC. (Source: EPMA Journal)
Source: EPMA Journal - January 3, 2020 Category: International Medicine & Public Health Source Type: research
