Artificial intelligence to improve ischemia prediction in Rubidium Positron Emission Tomography —a validation study
ConclusionThe MPA model enhanced ischemia testing according to the PPPM framework:The MPA model improved individual prediction of ischemia significantly and could safely exclude ischemia based on readily available variables without advanced testing ( “predictive”).It reduced the proportion of patients in the intermediate PTP range. Therefore, it could be used as a gatekeeper to prevent patients from further unnecessary downstream testing, radiation exposure and costs ( “preventive”).Consequently, the MPA model could transform ischemia testing towards a more personalised diagnostic algorithm ( “personalised”). (...
Source: EPMA Journal - November 15, 2023 Category: International Medicine & Public Health Source Type: research
Conceptualised psycho-medical footprint for health status outcomes and the potential impacts for early detection and prevention of chronic diseases in the context of 3P medicine
ConclusionsWe have demonstrated the feasibility of creating dynamic visualizers of the evolutionary trends in the relationships between the domains of SHSQ-25 relative to health status outcomes. This will provide in-depth comprehension of the conceptual model to inform personalised strategies to circumvent SHS. Additionally, the findings have implications for both health care and disease prevention because at-risk individuals can be predicted and prioritised for monitoring, and targeted intervention can begin before their symptoms reach an irreversible stage. (Source: EPMA Journal)
Source: EPMA Journal - November 8, 2023 Category: International Medicine & Public Health Source Type: research
Predicting 1-, 3-, 5-, and 8-year all-cause mortality in a community-dwelling older adult cohort: relevance for predictive, preventive, and personalized medicine
ConclusionThe personalized risk prediction model can identify individuals at high risk of all-cause mortality, help offer primary care to prevent all-cause mortality, and provide personalized medical treatment for these high-risk individuals from the PPPM perspective. Strict control of daily liquor consumption, lowering fasting glucose, raising hemoglobin, controlling heart rate, and treatment of heart block could be beneficial for improving survival in elderly populations. (Source: EPMA Journal)
Source: EPMA Journal - November 3, 2023 Category: International Medicine & Public Health Source Type: research
Emerging frontiers of artificial intelligence and machine learning in ischemic stroke: a comprehensive investigation of state-of-the-art methodologies, clinical applications, and unraveling challenges
AbstractAt present, stroke remains the second highest cause of death globally and a leading cause of disability. From 1990 to 2019, the absolute number of strokes worldwide increased by 70.0%, and the prevalence of stroke increased by 85.0%, causing millions of deaths and disability. Ischemic stroke accounts for the majority of strokes, which is caused by arterial occlusion. Effective primary prevention strategies, early diagnosis, and timely interventions such as rapid reperfusion are in urgent implementation to control ischemic stroke. Otherwise, the stroke burden will probably continue to grow across the world as a resu...
Source: EPMA Journal - November 2, 2023 Category: International Medicine & Public Health Source Type: research
Causal relationship between gut Prevotellaceae and risk of sepsis: a two-sample Mendelian randomization and clinical retrospective study in the framework of predictive, preventive, and personalized medicine
ConclusionOur results revealed thatPrevotellaceae was causally associated with sepsis and affected the prognosis of sepsis patients. These findings may provide insights to clinicians on developing improved sepsis PPPM strategies. (Source: EPMA Journal)
Source: EPMA Journal - October 12, 2023 Category: International Medicine & Public Health Source Type: research
Development and validation of a short-form suboptimal health status questionnaire
ConclusionsWe developed a short form of the SHS questionnaire that demonstrated sound reliability and validity when assessing SHS in Chinese residents. From a PPPM/3PM perspective, the SHSQ-SF is recommended for the rapid screening of individuals with SHS in large-scale populations. (Source: EPMA Journal)
Source: EPMA Journal - September 12, 2023 Category: International Medicine & Public Health Source Type: research
Identification of novel serum protein biomarkers in the context of 3P medicine for intravenous leiomyomatosis: a data-independent acquisition mass spectrometry-based proteomics study
ConclusionFour hub proteins were eventually identified based on the integrated bioinformatics analyses. This study potentiates the promising application of these novel biomarkers to predict the prognosis or progression of IVL by a 3PM approach. (Source: EPMA Journal)
Source: EPMA Journal - September 4, 2023 Category: International Medicine & Public Health Source Type: research
Machine learning –couched treatment algorithms tailored to individualized profile of patients with primary anterior chamber angle closure predisposed to the glaucomatous optic neuropathy
AbstractBackgroundPrimary angle closure glaucoma (PACG) is still one of the leading causes of irreversible blindness, with a trend towards an increase in the number of patients to 32.04 million by 2040, an increase of 58.4% compared with 2013. Health risk assessment based on multi-level diagnostics and machine learning –couched treatment algorithms tailored to individualized profile of patients with primary anterior chamber angle closure are considered essential tools to reverse the trend and protect vulnerable subpopulations against health-to-disease progression.AimTo develop a methodology for personalized choice of an ...
Source: EPMA Journal - August 17, 2023 Category: International Medicine & Public Health Source Type: research
The correlation between primary open-angle glaucoma (POAG) and gut microbiota: a pilot study towards predictive, preventive, and personalized medicine
ConclusionThis bioinformatic study elucidates NFKB1, IL18, KITLG, TLR9, FKBP2, and HDAC4 as hub genes for POAG and GM regulation. Immune response modulated by macrophages plays an important role in POAG and may be potential targets for future predictive, preventive, and personalized diagnosis and treatment. (Source: EPMA Journal)
Source: EPMA Journal - August 11, 2023 Category: International Medicine & Public Health Source Type: research
Quantitative phosphoproteomics reveals molecular pathway network alterations in human early-stage primary hepatic carcinomas: potential for 3P medical approach
ConclusionsIdentification and annotation of phosphoproteomes and phosphorylation-mediated signaling pathways in human early-stage primary hepatic carcinoma tissues provided new directions for tumor prevention and treatment, which (i) helps to enrich phosphorylation functional research and develop new biomarkers; (ii) enriches phosphorylation-mediated signaling pathways to gain a deeper understanding of the underlying mechanisms of early-stage primary hepatic carcinoma; and (iii) develops anti-tumor drugs that facilitate targeted phosphorylated sites. We recommend quantitative phosphoproteomics in early-stage primary hepati...
Source: EPMA Journal - August 10, 2023 Category: International Medicine & Public Health Source Type: research
Identifying oxidative stress-related biomarkers in idiopathic pulmonary fibrosis in the context of predictive, preventive, and personalized medicine using integrative omics approaches and machine-learning strategies
ConclusionWithin the framework of PPPM, this work comprehensively explored the role of OSRGs and their mediated cellular senescence and immune processes in the progress of IPF and assessed their capabilities aspredictors of high oxidative stress and disease progression,targets of the vicious loop between regulated pulmonary fibrosis and OS for targeted secondary and tertiary prevention, andreferences for personalized antioxidant and antifibrotic therapies. (Source: EPMA Journal)
Source: EPMA Journal - July 31, 2023 Category: International Medicine & Public Health Source Type: research
Royal jelly: a predictive, preventive and personalised strategy for novel treatment options in non-communicable diseases
AbstractRoyal jelly (RJ) is a bee product produced by young adult worker bees, composed of water, proteins, carbohydrates and lipids, rich in bioactive components with therapeutic properties, such as free fatty acids, mainly 10-hydroxy-trans-2-decenoic acid (10-H2DA) and 10-hydroxydecanoic acid (10-HDA), and major royal jelly proteins (MRJPs), as well as flavonoids, most flavones and flavonols, hormones, vitamins and minerals. In vitro, non-clinical and clinical studies have confirmed its vital role as an antioxidant and anti-inflammatory. This narrative review discusses the possible effects of royal jelly on preventing co...
Source: EPMA Journal - July 18, 2023 Category: International Medicine & Public Health Source Type: research
COVID-19 lessons to protect populations against future pandemics by implementing PPPM principles in healthcare
AbstractThe coronavirus disease 2019 (COVID-19) pandemic has continued for more than 3 years, placing a huge burden on society worldwide. Although the World Health Organization (WHO) has declared an end to COVID-19 as a Public Health Emergency of International Concern (PHEIC), it is still considered a global threat. Previously, there has been a long debate as to whether the COVID-19 emergency will eventually end or transform into a more common infectious disease from a PHEIC, and how should countries respond to similar pandemics in the future more time-efficiently and cost-effectively. We reviewed the past, middle and cu...
Source: EPMA Journal - July 14, 2023 Category: International Medicine & Public Health Source Type: research
Anatomic characteristics of shoulder based on MRI accurately predict incomplete rotator cuff injuries in patients: relevance for predictive, preventive, and personalized healthcare strategies
ConclusionsEight independent factors that accurately predicted IRCI were determined using MRI anatomical findings. These personalized factors can prevent unnecessary diagnostic interventions (e.g., arthroscopy) and can assist surgeons in implementing individualized clinical decisions in medical practice, thus addressing the goals of PPPM. (Source: EPMA Journal)
Source: EPMA Journal - July 13, 2023 Category: International Medicine & Public Health Source Type: research
Genetically predicted the causal relationship between gut microbiota and infertility: bidirectional Mendelian randomization analysis in the framework of predictive, preventive, and personalized medicine
ConclusionsOur results provided evidence for the causal relationship between some gut microbiota and male and female infertility. These findings might be valuable in providing personalized treatment options for preventing infertility and improving reproductive function by monitoring and regulating the gut microbiota of infertility patients in the context of PPPM. Moreover, detecting the abundance of microbiota in feces can support preventive and personalized strategies, which may benefit more infertility patients. (Source: EPMA Journal)
Source: EPMA Journal - July 7, 2023 Category: International Medicine & Public Health Source Type: research
