Specific properties of probiotic strains: relevance and benefits for the host
ConclusionWe recognized strain-dependent properties of studied LAB and bifidobacteria probiotic strains (adhesive ability, resistance to antibiotics, and gut biological fluids) and discussed potential for most effective individualized treatment for gut and distant sites microbiome modulation. (Source: EPMA Journal)
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research
Pathology-specific molecular profiles of saliva in patients with multiple dental caries —potential application for predictive, preventive and personalised medical services
ConclusionThe detected features in the IR spectra of mixed saliva as well as the calculated changes in the ratios between organic and inorganic components can be used as biomarkers of cariogenesis in the oral cavity, as a diagnostic criterion in the analysis of the oral fluid samples. (Source: EPMA Journal)
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research
Diabetes care in figures: current pitfalls and future scenario
AbstractDiabetes mellitus (DM) epidemic —on a global scale—is a major and snowballing threat to public health, healthcare systems and economy, due to the cascade of pathologies triggered in a long-term manner after the DM manifestation. There are remarkable differences in the geographic disease spread and acceleration of an increasing DM prevalence recorded. Specifically, the highest initial prevalence of DM was recorded in the Eastern-Mediterranean region in 1980 followed by the highest acceleration of the epidemic characterised by 0.23% of an annual increase resulted in 2.3 times higher prevalence in the year 2014. I...
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research
The influence of mothers ’ oral health behaviour and perception thereof on the dental health of their children
ConclusionsMaternal oral health was significantly associated with dental health of their children. Not only did maternal dental anxiety influence oral health of mothers but it was also a concomitant factor in the development of children ’s dental anxiety. The education programme on mothers’ oral health-related knowledge can be a target for improvement of the oral health of mothers and children. (Source: EPMA Journal)
Source: EPMA Journal - June 1, 2018 Category: International Medicine & Public Health Source Type: research
Diabetes care in figures: current pitfalls and future scenario
AbstractDiabetes mellitus (DM) epidemic —on a global scale—is a major and snowballing threat to public health, healthcare systems and economy, due to the cascade of pathologies triggered in a long-term manner after the DM manifestation. There are remarkable differences in the geographic disease spread and acceleration of an increasing DM prevalence recorded. Specifically, the highest initial prevalence of DM was recorded in the Eastern-Mediterranean region in 1980 followed by the highest acceleration of the epidemic characterised by 0.23% of an annual increase resulted in 2.3 times higher prevalence in the year 2014. I...
Source: EPMA Journal - May 22, 2018 Category: International Medicine & Public Health Source Type: research
Novel concept to guide systolic heart failure medication by repeated biomarker testing —results from TIME-CHF in context of predictive, preventive, and personalized medicine
ConclusionThe data of this post hoc analysis suggest that decision-making using repeated biomarker measurements may be very promising in bringing treatment of heart failure to a new level in the context of predictive, preventive, and personalized medicine. Clearly, prospective testing is needed before this novel concept can be adopted.Clinical trial registrationisrctn.org, identifier: ISRCTN43596477 (Source: EPMA Journal)
Source: EPMA Journal - May 13, 2018 Category: International Medicine & Public Health Source Type: research
Mental stress as consequence and cause of vision loss: the dawn of psychosomatic ophthalmology for preventive and personalized medicine
AbstractThe loss of vision after damage to the retina, optic nerve, or brain has often grave consequences in everyday life such as problems with recognizing faces, reading, or mobility. Because vision loss is considered to be irreversible and often progressive, patients experience continuous mental stress due to worries, anxiety, or fear with secondary consequences such as depression and social isolation. While prolonged mental stress is clearly aconsequence of vision loss, it may also aggravate the situation. In fact, continuous stress and elevated cortisol levels negatively impact the eye and brain due to autonomous nerv...
Source: EPMA Journal - May 9, 2018 Category: International Medicine & Public Health Source Type: research
The influence of mothers ’ oral health behaviour and perception thereof on the dental health of their children
ConclusionsMaternal oral health was significantly associated with dental health of their children. Not only did maternal dental anxiety influence oral health of mothers but it was also a concomitant factor in the development of children ’s dental anxiety. The education programme on mothers’ oral health-related knowledge can be a target for improvement of the oral health of mothers and children. (Source: EPMA Journal)
Source: EPMA Journal - April 26, 2018 Category: International Medicine & Public Health Source Type: research
Pathology-specific molecular profiles of saliva in patients with multiple dental caries —potential application for predictive, preventive and personalised medical services
ConclusionThe detected features in the IR spectra of mixed saliva as well as the calculated changes in the ratios between organic and inorganic components can be used as biomarkers of cariogenesis in the oral cavity, as a diagnostic criterion in the analysis of the oral fluid samples. (Source: EPMA Journal)
Source: EPMA Journal - April 25, 2018 Category: International Medicine & Public Health Source Type: research
Specific properties of probiotic strains: relevance and benefits for the host
ConclusionWe recognized strain-dependent properties of studied LAB and bifidobacteria probiotic strains (adhesive ability, resistance to antibiotics, and gut biological fluids) and discussed potential for most effective individualized treatment for gut and distant sites microbiome modulation. (Source: EPMA Journal)
Source: EPMA Journal - April 13, 2018 Category: International Medicine & Public Health Source Type: research
Premenopausal breast cancer: potential clinical utility of a multi-omics based machine learning approach for patient stratification
AbstractBackgroundThe breast cancer (BC) epidemic is a multifactorial disease attributed to the early twenty-first century: about two million of new cases and half a million deaths are registered annually worldwide. New trends are emerging now: on the one hand, with respect to the geographical BC prevalence and, on the other hand, with respect to the age distribution. Recent statistics demonstrate that young populations are getting more and more affected by BC in both Eastern and Western countries. Therefore, the old rule “the older the age, the higher the BC risk” is getting relativised now. Accumulated evidence shows...
Source: EPMA Journal - April 11, 2018 Category: International Medicine & Public Health Source Type: research
Preventive, predictive, and personalized medicine for effective and affordable cancer care
AbstractPreventive, predictive, and personalized medicine (PPPM) has created a wealth of new opportunities but added also new complexities and challenges. The European Cancer Prevention Organization already embraced unanimously molecular biology for primary and secondary prevention. The rapidly exploding genomic language and complexity of methods face oncologists with exponentially growing knowledge they need to assess and apply. Tissue specimen quality becomes one major concern. Some new innovative medicines cost beyond any reasonable threshold of financial support from patients, health care providers, and governments and...
Source: EPMA Journal - March 26, 2018 Category: International Medicine & Public Health Source Type: research
Heart rate variability: the comparison between high tension and normal tension glaucoma
ConclusionPatients with NTG have more pronounced disturbance of autonomic nervous system than HTG patients, which is manifested with the activation of sympathetic nervous system in response to CPT. This finding refers to the NTG pathogenesis and suggests the use of HRV assessment in glaucoma diagnosis and monitoring. (Source: EPMA Journal)
Source: EPMA Journal - February 22, 2018 Category: International Medicine & Public Health Source Type: research
Individualised patient profile: clinical utility of Flammer syndrome phenotype and general lessons for predictive, preventive and personalised medicine
AbstractThis case report introduces a female patient, who since her teenager age evidently suffers from Flammer syndrome (FS) as the clearly defined sub-optimal health condition. Further, the patient has experienced collateral pathological conditions which primarily might be linked to the family (genetic) predisposition, but the development of which could be synergistically promoted by the FS-phenotype. The facts are thoroughly analysed and consequent hypotheses are presented, which are indicative for highly desirable predictive diagnostics and targeted preventive measures to be created based on the accurate interpretation...
Source: EPMA Journal - February 22, 2018 Category: International Medicine & Public Health Source Type: research
Clinical and laboratory evaluation of microstructural changes in the physical, mechanical and chemical properties of dental filling materials under the influence of an electromagnetic field
AbstractRestorative filling materials used for dental caries prevention and treatment consist of various components including monomers or oligomers, which play a significant role in forming the main structure of these materials, as well as in characterising their physical, mechanical and chemical properties. The necessity for the development and improvement of structural characteristics of polymeric dental filling materials intended for caries prevention and their life duration increase served as the initiating factor of our research. According to the research purpose and challenges, we studied the changes in the physical,...
Source: EPMA Journal - February 21, 2018 Category: International Medicine & Public Health Source Type: research
