Preterm human milk: associations between perinatal factors and hormone concentrations throughout lactation.
CONCLUSION: Maternal, infant and environmental factors during the perinatal period were associated with milk compositional profiles throughout lactation. Further clinical trials should investigate the impact of such changes in terms of long-term infant outcomes. IMPACT: Human milk is the best nutrition for the infant. However, its composition may be susceptible to alterations determined by pathological conditions mother and infant may face throughout pregnancy and in the perinatal period.This study found that perinatal factors are associated with human milk composition from early to late lactation.If human milk compos...
Source: Pediatric Research - July 29, 2020 Category: Pediatrics Authors: Galante L, Reynolds CM, Milan AM, Alexander T, Bloomfield FH, Cameron-Smith D, Pundir S, Vickers MH, DIAMOND study group Tags: Pediatr Res Source Type: research

Incidence of invasive Group B Streptococcal infection and the risk of infant death and cerebral palsy: a Norwegian Cohort Study.
CONCLUSION: Despite a relatively low incidence of invasive GBS infection in Norway, the risk of death and CP remains high. Improvements in prevention strategies are needed. IMPACT: During the first decade of the twenty-first century, invasive GBS disease in infancy is still associated with high mortality.Despite the overall low incidence of invasive GBS disease, the incidence of LOD increased during the study period.The finding that invasive GBS infection in the neonatal period or during infancy is associated with an excess risk of CP, comparable to the risk following moderate preterm birth and moderate low Apgar scor...
Source: Pediatric Research - July 29, 2020 Category: Pediatrics Authors: Mynarek M, Bjellmo S, Lydersen S, Afset JE, Andersen GL, Vik T Tags: Pediatr Res Source Type: research

Genome-wide association study identifies a novel maternal gene  × stress interaction associated with spontaneous preterm birth.
CONCLUSION: We demonstrated a significant maternal PTPRD × stress interaction on sPTB risk. This finding, if further confirmed, may provide new insight into individual susceptibility to stress-induced sPTB. IMPACT: This was the first preterm study to demonstrate a significant genome-wide gene-stress interaction in African Americans, specifically, PTPRD gene variants can interact with maternal perceived stress to affect risk of spontaneous preterm birth.The PTPRD × maternal stress interaction was demonstrated in African Americans and replicated in both African Americans and Cauca...
Source: Pediatric Research - July 29, 2020 Category: Pediatrics Authors: Hong X, Surkan P, Zhang B, Keiser A, Ji Y, Ji H, Burd I, Bustamante-Helfrich B, Ogunwole S, Tang WY, Liu L, Pearson C, Cerda S, Zuckerman B, Hao L, Wang X Tags: Pediatr Res Source Type: research

Predictors of oxylipins in a healthy pediatric population.
CONCLUSIONS: In healthy children, oxylipin levels change with age. Oxylipins associated with precursor FAs more often in plasma than RBC or diet, suggesting that inflammatory regulation leading to FA release into plasma may also be a determinant of oxylipin generation. IMPACT: This is the first study to examine predictors of oxylipins in healthy children at risk of type 1 diabetes.In healthy children at risk of type 1 diabetes, many oxylipins change with age, and most oxylipins do not differ by sex or race/ethnicity.Environmental tobacco smoke exposure was associated with the presence of lipoxin A4.Omega-6- and omega-...
Source: Pediatric Research - July 29, 2020 Category: Pediatrics Authors: Buckner T, Vanderlinden LA, Johnson RK, DeFelice BC, Carry PM, Seifert J, Waugh K, Dong F, Fiehn O, Clare-Salzler M, Rewers M, Norris JM Tags: Pediatr Res Source Type: research

Optimized blood culture strategy to document febrile neutropenia.
CONCLUSIONS: Bacteremia detection was improved. This proof-of-concept study shows benefits of combining the single-sampling strategy with large weight-adapted blood sampling strategy during EFN. IMPACT: Combination of single-sampling and weight-adapted blood culture strategies showed benefits in the documentation of bloodstream infections during febrile neutropenia.Bacteremia detection was improved in this preliminary study and this warrants further evaluation in the overall pediatric population.We observed no adverse effects associated with the new strategy while overall blood sparing was improved and handling of int...
Source: Pediatric Research - July 28, 2020 Category: Pediatrics Authors: Lamy B, Dutron S, Haouy S, Saumet L, Marchandin H, Sirvent N Tags: Pediatr Res Source Type: research

Global Pediatric Research Investigator: Dr. Felicity Gumbo.
PMID: 32722663 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 28, 2020 Category: Pediatrics Authors: Gumbo F Tags: Pediatr Res Source Type: research

Residential dust lead levels and the risk of childhood lead poisoning in United States children.
CONCLUSIONS: The EPA's residential dust lead regulations place children at increased risk of lead poisoning. We recommend adopting more protective dust lead standards. IMPACT: We determined whether children are at increased risk of lead poisoning with the 2019 EPA residential post-abatement lead clearance standards being higher than dust lead hazard standards.In this observational study, 2019 EPA dust lead clearance standards were associated with increased risk of lead poisoning compared to the revised dust lead hazard standard. Both EPA standards were associated with increased risk of lead poisoning compared to more ...
Source: Pediatric Research - July 28, 2020 Category: Pediatrics Authors: Braun JM, Yolton K, Newman N, Jacobs DE, Taylor M, Lanphear BP Tags: Pediatr Res Source Type: research

Stigma surrounding functional seizures.
PMID: 32722665 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 28, 2020 Category: Pediatrics Authors: Hansen AS, Nielsen RE, Christensen J, Stone J, Rask CU Tags: Pediatr Res Source Type: research

Motor repertoire is age-inadequate in infants with cystic fibrosis.
il;elik U Abstract BACKGROUND: General movements (GMs) in infants occur as fidgety movements (FMs) between postterm 9 and 20 weeks. We aimed to evaluate FMs and motor repertoire in infants with cystic fibrosis (CF) and their relation with clinical findings. METHODS: Demographic and clinical characteristics were recorded. FMs and motor repertoire were analyzed from a 5-min video recording of each infant. Videos were rated based on the Prechtl General Movement Assessment and motor optimality score (MOS) was calculated. RESULTS: The analysis included 18 infants with CF and 20 healthy infants at postterm age...
Source: Pediatric Research - July 27, 2020 Category: Pediatrics Authors: Tekerlek H, Mutlu A, İnal-İnce D, Livanelioğlu A, Kahraman A, Eryılmaz-Polat S, Karakaya J, Özçelik U Tags: Pediatr Res Source Type: research

Shoring up the safety net for children in the COVID-19 pandemic.
PMID: 32712625 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 26, 2020 Category: Pediatrics Authors: Cheng TL, Moon M, Artman M, Pediatric Policy Council Tags: Pediatr Res Source Type: research

Odor identification performance in children aged 3-6 years.
Abstract BACKGROUND: While valid and reliable olfactory tests have been developed for children aged>5 years, olfactory testing has not been systematically evaluated in younger children. The aim of this study was to evaluate the reliability and validity of the "U-Sniff" odor identification test in children aged 3-6 years. METHODS: We included 160 healthy children (age range 3-6 years) and 14 congenitally anosmic children. Participants were investigated in two identical sessions. The "U-Sniff" test was used to evaluate olfactory function. A picture identification test (PIT) and the Kasel-...
Source: Pediatric Research - July 26, 2020 Category: Pediatrics Authors: Schriever VA, Zscheile L, Gellrich J, Hummel T Tags: Pediatr Res Source Type: research

Global Pediatric Research Investigator: Mohammod Jobayer Chisti.
PMID: 32711398 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 25, 2020 Category: Pediatrics Authors: Chisti MJ Tags: Pediatr Res Source Type: research

Brain creatine alteration and executive function deficits in children born very preterm.
PMID: 32711399 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 25, 2020 Category: Pediatrics Authors: Ostojic SM Tags: Pediatr Res Source Type: research

Determinants of neurological outcome in neonates with congenital heart disease following heart surgery.
CONCLUSION: For HLHS and d-TGA patients, duration of mechanical ventilation and DHCA are associated with adverse neurologic outcome. Neonatal brain MRI commonly demonstrates acquired brain injuries, but the clinical impact of these abnormalities are not often seen before 2 years of age. IMPACT: Acquired brain injury is common in high-risk neonates with CHD but poor neurological outcome was not predicted by severity of injury or lesion subtype. Longer stay in ICU is associated with postoperative brain injuries on MRI.Total duration of ventilation > 12 days is predictive of adverse neurological outcome ...
Source: Pediatric Research - July 25, 2020 Category: Pediatrics Authors: Kuhn VA, Carpenter JL, Zurakowski D, Reitz JG, Tague L, Donofrio MT, Murnick J, Axt-Fliedner R, Limperopoulos C, Yerebakan C Tags: Pediatr Res Source Type: research

Strawberry mark: our daughter's journey with an infantile hemangioma.
PMID: 32711401 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 25, 2020 Category: Pediatrics Authors: Hanson T, Hanson J Tags: Pediatr Res Source Type: research

October ECI biocommentary.
PMID: 32702708 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 23, 2020 Category: Pediatrics Authors: Merianos AL Tags: Pediatr Res Source Type: research

The bioavailability and maturing clearance of doxapram in preterm infants.
CONCLUSIONS: Dosing of doxapram only based on bodyweight results in the highest exposure in preterm infants with the lowest PNA and GA. Therefore, dosing may need to be adjusted for GA and PNA to minimize the risk of accumulation and adverse events. For switching to oral therapy, a 33% dose increase is required to maintain exposure. IMPACT: Current dosing regimens of doxapram in preterm infants only based on bodyweight result in the highest exposure in infants with the lowest PNA and GA.Dosing of doxapram may need to be adjusted for GA and PNA to minimize the risk of accumulation and adverse events.Describing the phar...
Source: Pediatric Research - July 22, 2020 Category: Pediatrics Authors: Flint RB, Simons SHP, Andriessen P, Liem KD, Degraeuwe PLJ, Reiss IKM, Heine RT, Engbers AGJ, Koch BCP, Groot R, Burger DM, Knibbe CAJ, Völler S, DINO Research Group Tags: Pediatr Res Source Type: research

Very preterm birth results in later lower platelet activation markers.
Abstract BACKGROUND: Premature birth entails an adverse cardiovascular risk profile, but the underlying mechanisms are insufficiently understood. Here, we employed an unbiased cardiovascular proteomics approach to profile former very preterm-born preschoolers. METHODS: This observational study investigated differences in plasma concentrations of 79 proteins, including putative cardiovascular biomarkers between very preterm- and term-born children on average 5.5 years old (53.1% male) using multiple-reaction monitoring mass spectrometry. RESULTS: Very preterm-born (n = 38; median gestational...
Source: Pediatric Research - July 22, 2020 Category: Pediatrics Authors: Pechlaner R, Posod A, Yin X, Burnap SA, Kiechl SJ, Mayr M, Kiechl S, Kiechl-Kohlendorfer U Tags: Pediatr Res Source Type: research

Thymus size in children with moderate malnutrition: a cohort study from Burkina Faso.
CONCLUSIONS: In children with MAM, the thymus is smaller in children with anaemia or malaria, and grows with recovery. Assuming that thymus size reflects vulnerability, low MUAC seems to identify more vulnerable children than low WLZ in children with MAM. IMPACT: Thymus atrophy is known to be a marker of the immunodeficiency associated with malnutrition in children.In children with moderate malnutrition, we found the thymus to be smaller in children with anaemia or malaria.Assuming that thymus size reflects vulnerability, low MUAC seems to identify more vulnerable children than low weight for length.Thymus atrophy app...
Source: Pediatric Research - July 20, 2020 Category: Pediatrics Authors: Rytter MJH, Cichon B, Fabiansen C, Yameogo CW, Windinmi SZ, Michaelsen KF, Filteau S, Jeppesen DL, Friis H, Briend A, Christensen VB Tags: Pediatr Res Source Type: research

Carbon dioxide as a drug in neonatology.
PMID: 32688369 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 20, 2020 Category: Pediatrics Authors: Molloy EJ, Cummins EP Tags: Pediatr Res Source Type: research

Inclusion of children and pregnant women in COVID-19 intervention trials.
PMID: 32688370 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 20, 2020 Category: Pediatrics Authors: Malhotra A, Kumar A, Roehr CC, den Boer MC Tags: Pediatr Res Source Type: research

Kawasaki disease: SOCS2-AS1/miR-324-5p/CUEDC2 axis regulates the progression of human umbilical vein endothelial cells.
CONCLUSIONS: SOCS2-AS1 upregulates CUEDC2 via inhibiting miR-324-5p to promote the progression of HUVECs in KD, providing new insights for KD treatment. IMPACT: SOCS2-AS1 is highly expressed in the serum of KD patients.SOCS2-AS1 contributes to cell proliferation in HUVECs of KD through elevating CUEDC2 expression by sequestering miR-324-5p.SOCS2-AS1/miR-324-5p/CUEDC2 axis exerts a progression-facilitating function in KD.These findings suggest SOCS2-AS1 as a novel potential target for KD treatment. PMID: 32688371 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 20, 2020 Category: Pediatrics Authors: Zhao Q, Chen D Tags: Pediatr Res Source Type: research

Spontaneous and apnea arousals from sleep in preterm infants.
n T Abstract BACKGROUND: The significance of arousal in apnea termination in preterm infants is not known. METHODS: We investigated the appearance of arousals from sleep with polysomnography for 21 preterm infants at a median age of 36 gestational weeks. RESULTS: The polysomnographic appearance of sleep was fragmented by frequent arousals. The number of spontaneous arousals unrelated to apneas was 18 per h in sleep; higher in rapid eye movement (REM) sleep than in non-REM sleep (p 
Source: Pediatric Research - July 18, 2020 Category: Pediatrics Authors: Seppä-Moilanen M, Andersson S, Kirjavainen T Tags: Pediatr Res Source Type: research

A literature review of 2019 novel coronavirus (SARS-CoV2) infection in neonates and children.
Abstract At the time of writing, there are already millions of documented infections worldwide by the novel coronavirus 2019 (2019-nCoV or severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)), with hundreds of thousands of deaths. The great majority of fatal events have been recorded in adults older than 70 years; of them, a large proportion had comorbidities. Since data regarding the epidemiologic and clinical characteristics in neonates and children developing coronavirus disease 2019 (COVID-19) are scarce and originate mainly from one country (China), we reviewed all the current literature from 1 Decemb...
Source: Pediatric Research - July 17, 2020 Category: Pediatrics Authors: Di Nardo M, van Leeuwen G, Loreti A, Barbieri MA, Guner Y, Locatelli F, Ranieri VM Tags: Pediatr Res Source Type: research

The newborn Fmr1 knockout mouse: a novel model of excess ubiquinone and closed mitochondrial permeability transition pore in the developing heart.
CONCLUSION: These findings establish the newborn Fmr1 KO mouse as a novel model of excess ubiquinone and closed mPTP in the developing heart. Such a model may help provide insight into the biology of cardiac development and pathophysiology of neonatal heart failure. IMPACT: Ubiquinone is in excess and the mPTP is closed in the developing FXS heart.Strengthens evidence of open mPTP probability in the normally developing postnatal murine heart and provides new evidence for premature closure of the mPTP in Fmr1 mutants.Establishes a novel model of excess CoQ and a closed pore in the developing heart. Such a model will be...
Source: Pediatric Research - July 16, 2020 Category: Pediatrics Authors: Barajas M, Wang A, Griffiths KK, Matsumoto K, Liu R, Homma S, Levy RJ Tags: Pediatr Res Source Type: research

Family separation during COVID-19.
PMID: 32668439 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 15, 2020 Category: Pediatrics Authors: McAdams R Tags: Pediatr Res Source Type: research

We can and we must do better to protect children from drinking water contaminants.
PMID: 32668440 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 15, 2020 Category: Pediatrics Authors: Evans S, Zajac L Tags: Pediatr Res Source Type: research

India's lockdown exit: are we prepared to lock horns with COVID-19 and dengue in the rainy season?
PMID: 32663834 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 14, 2020 Category: Pediatrics Authors: Dash N, Rose W, Nallasamy K Tags: Pediatr Res Source Type: research

DNA methylation in children with prenatal methamphetamine exposure and environmental adversity.
Abstract BACKGROUND: Methamphetamine (MA) use during pregnancy is a significant public health concern in the United States and affects long-term brain and behavioral development in children. We hypothesized that prenatal MA exposure would be related to greater DNA methylation of HSD11B2 and postnatal environmental stress. METHODS: The Infant Development, Environment, and Lifestyle Study (IDEAL), a longitudinal study of prenatal MA exposure enrolled mother-infant dyads in California, Hawaii, Iowa, and Oklahoma. Prenatal exposure was defined by maternal self-report and/or meconium toxicology screening. At ages ...
Source: Pediatric Research - July 14, 2020 Category: Pediatrics Authors: Oni-Orisan OO, Dansereau LM, Marsit CJ, Smith LM, Neal CR, Della Grotta SA, Padbury JF, Lester BM Tags: Pediatr Res Source Type: research

Maternal diabetes alters microRNA expression in fetal exosomes, human umbilical vein endothelial cells and placenta.
CONCLUSION: Exposure to DM during pregnancy alters miRNA expression in the offspring in a tissue-specific manner. IMPACT: miRNAs are differentially expressed in fetal tissues from offspring exposed to in utero diabetes mellitus compared to those who were not exposed.miRNA expression differs among tissue types (human umbilical vein endothelial cells, placenta and circulation exosomes) and response to diabetes exposure varies according to tissue of origin.miRNA expression is also affected by maternal and infant characteristics such as infant birth weight, infant sex, maternal age, and maternal BMI.miRNAs might be one of...
Source: Pediatric Research - July 14, 2020 Category: Pediatrics Authors: Shah KB, Chernausek SD, Teague AM, Bard DE, Tryggestad JB Tags: Pediatr Res Source Type: research

Glucocorticoids, sodium transport mediators, and respiratory distress syndrome in preterm infants.
Janer A Abstract BACKGROUND: Antenatal glucocorticoids (GCs) reduce respiratory distress syndrome (RDS) in preterm infants and are associated with reduced lung liquid content. Our aim was to assess whether airway gene expression of mediators of pulmonary epithelial sodium and liquid absorption, and further, respiratory morbidity, associate with cord blood GC concentrations. METHODS: The study included 64 infants delivered
Source: Pediatric Research - July 14, 2020 Category: Pediatrics Authors: Süvari L, Helve OM, Anneli Kari M, Ursula Turpeinen L, Anniina Palojärvi P, Leskinen MJ, Andersson S, Cecilia Janer A Tags: Pediatr Res Source Type: research

Correction: Biomarkers of ageing in New Zealand VLBW young adults and controls.
Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper. PMID: 32647334 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 9, 2020 Category: Pediatrics Authors: Darlow BA, Horwood J, Dhakal B, Harris SL, McKelvey VA, Elliott JM, Yang J, Mackay RJ Tags: Pediatr Res Source Type: research

Healthcare interventions improving and reducing quality of life in children at the end of life: a systematic review.
CONCLUSIONS: Use of patient-controlled symptom feedback, multidisciplinary palliative care teams with full-time practical support, inhalation therapy, and off-label sedative medication may improve QOL. Curative therapy may reduce QOL. IMPACT: QOL for children at the end of life may be improved with patient-controlled symptom feedback, multidisciplinary palliative care teams with full-time practical support, inhalation therapy, and off-label sedative medication.QOL for children at the end of life may be reduced with therapy with a curative intent, such as curative chemotherapy or stem cell transplant.A comprehensive ov...
Source: Pediatric Research - July 9, 2020 Category: Pediatrics Authors: Piette V, Beernaert K, Cohen J, Pauwels NS, Scherrens AL, van der Werff Ten Bosch J, Deliens L Tags: Pediatr Res Source Type: research

The potential impact of feeding formula-fed infants according to published recommendations.
PMID: 32634816 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 7, 2020 Category: Pediatrics Authors: Bloomfield FH, Agostoni C Tags: Pediatr Res Source Type: research

Circulating high-sensitivity troponin T and microRNAs as markers of myocardial damage during childhood leukaemia treatment.
Abstract BACKGROUND: We investigated whether plasma high-sensitivity cardiac troponin T (hs-cTnT) and circulating heart-associated microRNA (miRs) are increased in children with leukaemias during anthracycline-based chemotherapeutic treatment. METHODS: In vitro human pluripotent stem cell (hPSC)-derived cardiomyocyte model showed that miR-1, miR-133a, miR-208a, miR-208b, and miR-499 are released from cells into culture medium in a time- and dose-dependent manner on doxorubicin exposure. Left ventricular (LV) myocardial deformation and circulating heart-associated miRs and plasma hs-cTnT during and after compl...
Source: Pediatric Research - July 7, 2020 Category: Pediatrics Authors: Cheung YF, Li VW, Lai CT, Shin VY, Keung W, Cheuk DK, Kwong A, Li RA, Chan GC Tags: Pediatr Res Source Type: research

COVID-19 PICU guidelines: for high- and limited-resource settings.
Abstract Fewer children than adults have been affected by the COVID-19 pandemic, and the clinical manifestations are distinct from those of adults. Some children particularly those with acute or chronic comorbidities are likely to develop critical illness. Recently, a Multisystem Inflammatory Syndrome (MIS-C) has been described in children with these patients often requiring care in the Pediatric ICU. An international collaboration was formed to review the available evidence and develop evidence-based guidelines for the care of critically ill children with SARS-CoV-2 infection. Where the evidence was lacking, thos...
Source: Pediatric Research - July 7, 2020 Category: Pediatrics Authors: Kache S, Chisti MJ, Gumbo F, Mupere E, Zhi X, Nallasamy K, Nakagawa S, Lee JH, Di Nardo M, de la Oliva P, Katyal C, Anand KJS, de Souza DC, Lanziotti VS, Carcillo J Tags: Pediatr Res Source Type: research

European consensus recommendations for neonatal and paediatric retrievals of positive or suspected COVID-19 patients.
CONCLUSIONS: Our consensus recommendations aim to define current best-practice and should help guide transport teams dealing with infants and children with COVID-19 to work safely and effectively. IMPACT: We present European consensus recommendations on pertinent measures for transporting infants and children in times of the coronavirus (SARS-Cov-2 /COVID-19) pandemic. A panel of experts reviewed the evidence around transporting infants and children with proven or suspected COVID-19. Specific guidance on aspects of personal protective equipment, airway management and considerations for incubator and open stretcher tra...
Source: Pediatric Research - July 7, 2020 Category: Pediatrics Authors: Terheggen U, Heiring C, Kjellberg M, Hegardt F, Kneyber M, Gente M, Roehr CC, Jourdain G, Tissieres P, Ramnarayan P, Breindahl M, van den Berg J Tags: Pediatr Res Source Type: research

Serial assessment of fat and fat-free mass accretion in very preterm infants: a randomized trial.
CONCLUSIONS: Serial assessments of body composition in both intervention and control groups showed consistent increments in %BF. However, providing this information to clinicians did not influence nutritional practices or growth. IMPACT: Serial assessments of body composition in preterm infants at 32 and 36 weeks postmenstrual age show consistent increments in % body fat up to 3 months of corrected age.However, providing this information to the clinician did not influence nutritional practices or growth. PMID: 32634820 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 7, 2020 Category: Pediatrics Authors: Salas AA, Jerome ML, Chandler-Laney P, Ambalavanan N, Carlo WA Tags: Pediatr Res Source Type: research

The relationship between dog ownership, dog play, family dog walking, and pre-schooler social-emotional development: findings from the PLAYCE observational study.
CONCLUSIONS: Our findings highlight the possible physical activity and social-emotional developmental benefits of family dog ownership for pre-schoolers, and that these benefits may present in early childhood. IMPACT: Young children from dog-owning families had lower peer problems and conduct problems, and higher prosocial behaviors than children from non-dog-owning families.Children of dog-owning families who walked or played with their dog more often also had better prosocial behaviors.Positive social-emotional development was associated with dog ownership, family dog walking, and dog play in young children.Highligh...
Source: Pediatric Research - July 6, 2020 Category: Pediatrics Authors: Wenden EJ, Lester L, Zubrick SR, Ng M, Christian HE Tags: Pediatr Res Source Type: research

Shedding light on excessive crying in babies.
CONCLUSIONS: Our results offer novel insights into IC pathophysiology by demonstrating that, shortly after birth, the central nervous system of babies developing IC has already greater reactivity to sensory stimuli than that of their noncolicky peers. IMPACT: Shortly after birth, the central nervous system of colicky infants has a greater sensitivity to olfactory stimuli than that of their noncolicky peers. This early sensitivity explains as much as 48% of their subsequent crying behavior at 6 weeks of life.Brain activation patterns to olfactory stimuli in colicky infants include not only primary olfactory areas but a...
Source: Pediatric Research - July 6, 2020 Category: Pediatrics Authors: Adam-Darque A, Freitas L, Grouiller F, Sauser J, Lazeyras F, Van De Ville D, Pollien P, Garcia-Rodenas CL, Bergonzelli G, Hüppi PS, Leuchter RH Tags: Pediatr Res Source Type: research

Impact of integrated clinical decision support systems in the management of pediatric acute kidney injury: a pilot study.
Abstract BACKGROUND: Acute kidney injury (AKI) is common but not often recognized. Early recognition and management may improve patient outcomes. METHODS: This is a prospective, nonrandomized study of clinical decision support (CDS) system [combining electronic alert and standardized care pathway (SCP)] to evaluate AKI detection and progression in hospitalized children. The study was done in three phases: pre-, intervention (CDS) and post. During CDS, text-page with AKI stage and link to SCP was sent to patient's contact provider at diagnosis of AKI using creatinine. The SCP provided guidelines on AKI managem...
Source: Pediatric Research - July 3, 2020 Category: Pediatrics Authors: Menon S, Tarrago R, Carlin K, Wu H, Yonekawa K Tags: Pediatr Res Source Type: research

Machine learning for automatic identification of thoracoabdominal asynchrony in children.
CONCLUSIONS: With this pilot study, we show the efficacy of the ICP feature and ML in developing an accurate automated approach to identifying TAA that reduces time and effort for diagnosis. ICP also helped improve consensus among experts. IMPACT: Our article presents an automated approach to identifying thoracic abdominal asynchrony using machine learning and the pneuRIP device.It also shows how a modified statistical measure of cumulative frequency can be used to visualize the progression of the pulmonary functionality along time.The pulmonary testing method we developed gives patients and doctors a noninvasive and ...
Source: Pediatric Research - July 3, 2020 Category: Pediatrics Authors: Ratnagiri MV, Ryan L, Strang A, Heinle R, Rahman T, Shaffer TH Tags: Pediatr Res Source Type: research

Developmental effects on sleep-wake patterns in infants receiving a cow's milk-based infant formula with an added prebiotic blend: a Randomized Controlled Trial.
CONCLUSIONS: Results indicate faster consolidation of daytime waking state in infants receiving prebiotics and support home-based actigraphy to assess early sleep-wake patterns. A prebiotic effect on wake organization is consistent with influence on the gut-brain axis and warrants further investigation. IMPACT: Few studies have evaluated nutritive effects of prebiotics on infant behavior state, cortisol awakening response, sleep-wake entrainment, and gut microbiome.Faster consolidation of daytime waking state was demonstrated in infants receiving a prebiotic blend in infant formula through ~4 months of age.Shorter epi...
Source: Pediatric Research - July 2, 2020 Category: Pediatrics Authors: Colombo J, Carlson SE, Algarin C, Reyes S, Chichlowski M, Harris CL, Wampler JL, Peirano P, Berseth CL Tags: Pediatr Res Source Type: research

COVID-19: Precautions with children in home mechanical ventilation.
PMID: 32615580 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 2, 2020 Category: Pediatrics Authors: Vasconcello-Castillo L, Torres-Castro R, Vera-Uribe R, Paiva R Tags: Pediatr Res Source Type: research

Pharmacokinetic study (phase I-II) of a new dobutamine formulation in preterm infants immediately after birth.
CONCLUSIONS: The wide variability in dobutamine metabolism in preterm infants requires awareness about the risk of under- or overtreatment. A delay of up to 3 h might be required before drawing blood samples to evaluate the effective dose. IMPACT: Small trials suggest dobutamine as the optimal drug in the preterm infant with haemodynamic insufficiency after birth.Age-related differences in drug pharmacokinetics may result in suboptimal treatments.The lack of formal studies in preterms results in inadequate data on efficacy and safety. This study provides data on the variability of the elimination half-life of d...
Source: Pediatric Research - July 1, 2020 Category: Pediatrics Authors: Pellicer A, Fernández R, Jullien V, Gleeson C, Bravo MC, Ortego PL, Sánchez L, Ybarra M, Rojas-Anaya H, Cabañas F, Koch A, Smith A, Rabe H, Neocirculation Consortium Tags: Pediatr Res Source Type: research

Hepcidin is a relevant iron status indicator in infancy: results from a randomized trial of early vs. delayed cord clamping.
CONCLUSIONS: Hepcidin is relevant as iron status indicator in early infancy and may be useful to detect ID. Levels
Source: Pediatric Research - July 1, 2020 Category: Pediatrics Authors: Berglund SK, Chmielewska AM, Domellöf M, Andersson O Tags: Pediatr Res Source Type: research

Turns out not where but who you're with that really matters.
PMID: 32599606 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - June 29, 2020 Category: Pediatrics Authors: Inder TE Tags: Pediatr Res Source Type: research

Acute-on-chronic stress in the time of COVID-19: assessment considerations for vulnerable youth populations.
PMID: 32599607 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - June 29, 2020 Category: Pediatrics Authors: Gabrielli J, Lund E Tags: Pediatr Res Source Type: research

Assessment of four pain scales for evaluating procedural pain in premature infants undergoing heel blood collection.
Abstract BACKGROUND: Procedural pain is underestimated in hospitalized preterm infants. The aim of this study was to assess the reliability, validity, and clinical utility of the Neonatal Facial Coding System (NFCS), Douleur Aiguë du Nouveau-né (DAN) scale, Neonatal Infant Pain Scale (NIPS), and Premature Infant Pain Profile (PIPP) in premature infants undergoing heel blood collection. We assume that the four scales were similar in reliablility and validity (but different in clinical utility). METHODS: The pain assessments were performed on 111 premature infants using the four scales. Internal con...
Source: Pediatric Research - June 29, 2020 Category: Pediatrics Authors: Xie W, Wang X, Huang R, Chen Y, Guo X Tags: Pediatr Res Source Type: research

Impact of pertussis-specific IgA, IgM, and IgG antibodies in mother's own breast milk and donor breast milk during preterm infant digestion.
CONCLUSIONS: Pertussis-specific antibodies from MBM were stable during infant digestion, whereas anti-pertussis IgA and IgG from DBM decreased in gastric contents. The constant region and variable region of antibodies and maternal immunization appear to be the critical factors for their stability to proteolytic digestion and pasteurization. IMPACT: Pertussis-specific antibodies from mother's breast milk were stable during infant digestion, whereas anti-pertussis IgA and IgG from donor breast milk decreased in gastric contents.The constant region and variable region of pertussis-specific antibodies and the maternal imm...
Source: Pediatric Research - June 29, 2020 Category: Pediatrics Authors: Demers-Mathieu V, Huston RK, Markell AM, McCulley EA, Martin RL, Dallas DC Tags: Pediatr Res Source Type: research