Curtailing PCOS.
;a AS Abstract Polycystic ovary syndrome (PCOS), characterized by hormonal imbalance and ovarian dysfunction, often starts during adolescence. Inconsistent diagnostic criteria, variable provider knowledge, and lack of consensus pose specific challenges for the care of women with PCOS. These factors encourage inaccurate diagnosis with both under and overdiagnosis. This unfavorable diagnostic experience exasperates affected women and limits timely opportunities for intervention to minimize associated comorbidities, especially during the transition from pediatric to adult care. Recognition of these issues in the care...
Source: Pediatric Research - October 18, 2019 Category: Pediatrics Authors: Witchel SF, Teede HJ, Peña AS Tags: Pediatr Res Source Type: research

Identifying adverse childhood experiences in pediatrics to prevent chronic health conditions.
Abstract Despite evidence that over 40% of youth in the United States have one or more adverse childhood experiences (ACEs), and that ACEs have cumulative, pernicious effects on lifelong health, few primary care clinicians routinely ask about ACEs. Lack of standardized and accurate clinical assessments for ACEs, combined with no point-of-care biomarkers of the "toxic stress" caused by ACEs, hampers prevention of the health consequences of ACEs. Thus, there is no consensus regarding how to identify, screen, and track ACEs, and whether early identification of toxic stress can prevent disease. In this revie...
Source: Pediatric Research - October 17, 2019 Category: Pediatrics Authors: Barnes AJ, Anthony BJ, Karatekin C, Lingras KA, Mercado R, Thompson LA Tags: Pediatr Res Source Type: research

Electrical activity of the diaphragm following a loading dose of caffeine citrate in ventilated preterm infants.
Abstract BACKGROUND: Administration of caffeine citrate can facilitate extubation. Our aim was to determine whether a loading dose of caffeine citrate given to ventilated, preterm infants affected the diaphragm electrical activity. METHODS: Infants
Source: Pediatric Research - October 17, 2019 Category: Pediatrics Authors: Williams EE, Hunt KA, Jeyakara J, Subba-Rao R, Dassios T, Greenough A Tags: Pediatr Res Source Type: research

Insights Image for "Effect of prebiotic and probiotic supplementation on neurodevelopment in preterm very low birth weight infants: findings from a meta-analysis".
Insights Image for "Effect of prebiotic and probiotic supplementation on neurodevelopment in preterm very low birth weight infants: findings from a meta-analysis". Pediatr Res. 2019 Oct 17;: Authors: Upadhyay RP, Taneja S, Chowdhury R, Strand TA, Bhandari N PMID: 31622976 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 17, 2019 Category: Pediatrics Authors: Upadhyay RP, Taneja S, Chowdhury R, Strand TA, Bhandari N Tags: Pediatr Res Source Type: research

Genotype-phenotype analysis of 523 patients by genetics evaluation and clinical exome sequencing.
Abstract BACKGROUND: As clinical exome sequencing (CES) becomes more common, understanding which patients are most likely to benefit and in what manner is critical for the general pediatrics community to appreciate. METHODS: Five hundred and twenty-three patients referred to the Pediatric Genetics clinic at Michigan Medicine were systematically phenotyped by the presence or absence of abnormalities for 13 body/organ systems by a Clinical Genetics team. All patients then underwent CES. RESULTS: Overall, 30% of patients who underwent CES had an identified pathogenic mutation. The most common phenotypes wer...
Source: Pediatric Research - October 16, 2019 Category: Pediatrics Authors: Ziats MN, Ahmad A, Bernat JA, Fisher R, Glassford M, Hannibal MC, Jacher JE, Weiser N, Keegan CE, Lee KN, Marzulla TB, O'Connor BC, Quinonez SC, Seemann L, Turner L, Bielas S, Harris NL, Ogle JD, Innis JW, Martin DM Tags: Pediatr Res Source Type: research

Association of apoptosis genes in PDCD1 but not PDCD1LG2, FAS, and FASLG with pediatric idiopathic uveitis in Han Chinese.
CONCLUSIONS: This study revealed that rs6710479 and rs7421861 in the PDCD1 gene confer susceptibility to PIU in Han Chinese. A stratified analysis showed that PDCD1/rs7565639 is associated with band keratopathy in PIU patients. PMID: 31618754 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 16, 2019 Category: Pediatrics Authors: Pang T, Du L, Li F, Liu Y, Ma X, Cao Q, Shi L, Li N, Kijlstra A, Yang P Tags: Pediatr Res Source Type: research

Bilirubin level 1 week after hepatoportoenterostomy predicts native liver survival in biliary atresia.
CONCLUSIONS: The serum post-HPE 1-week T-bil level may predict the long-term outcome in BA patients. A post-HPE 1-week T-bil ≤4.85 mg/dL correlated with better native liver survival and jaundice-free native liver survival in BA patients. PMID: 31618755 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 16, 2019 Category: Pediatrics Authors: Huang CY, Chang MH, Chen HL, Ni YH, Hsu HY, Wu JF Tags: Pediatr Res Source Type: research

Maternal hyperoxygenation for the human fetus: should studies be curtailed?
Abstract Congenital hypoplasia of left heart structures in fetuses frequently progresses with gestational development. Interference with cerebral development is common in these fetuses. Chronic maternal hyperoxygenation (MHO) has been recommended to increase left ventricular size and to limit cerebral damage. The effects of MHO on cerebral blood flow and metabolism have been studied in normal fetuses and fetuses with left heart hypoplasia. Maternal hyperoxygenation increases fetal pulmonary blood flow. This is associated with reduction of foramen ovale flow, thus limiting the increase in left ventricular output. M...
Source: Pediatric Research - October 10, 2019 Category: Pediatrics Authors: Rudolph AM Tags: Pediatr Res Source Type: research

Psychosocial and medical adversity associated with neonatal neurobehavior in infants born before 30 weeks gestation.
Abstract BACKGROUND: Psychosocial adversity escalates medical risk for poor outcomes in infants born
Source: Pediatric Research - October 10, 2019 Category: Pediatrics Authors: Hofheimer JA, Smith LM, McGowan EC, O'Shea TM, Carter BS, Neal CR, Helderman JB, Pastyrnak SL, Soliman A, Dansereau LM, DellaGrotta SA, Lester BM Tags: Pediatr Res Source Type: research

Review of bilirubin neurotoxicity I: molecular biology and neuropathology of disease.
Abstract Despite the availability of successful prevention strategies to prevent excessive hyperbilirubinemia, the neurological sequelae of bilirubin neurotoxicity (BNTx) still occur throughout the world. Kernicterus, encephalopathy due to BNTx, is now understood to be a spectrum of severity and phenotypes known as kernicterus spectrum disorder (KSD). A better understanding of the selective neuropathology and molecular biology of BNTx and using consistent clinical definitions of KSDs as outcome measure can lead to more accurately predicting the risk and causes of BNTx and KSDs. In Part I of our two-part review, we...
Source: Pediatric Research - October 10, 2019 Category: Pediatrics Authors: Riordan SM, Shapiro SM Tags: Pediatr Res Source Type: research

Immune recovery following bronchiolitis is linked to a drop in cytokine and LTC4 levels.
CONCLUSIONS: After bronchiolitis, cytokines and biomarkers linked to innate immune response in NPA decrease significantly in the recovery period accompanied by a drop in LTC4 levels; however, this reduction was lower in infants with post-bronchiolitis wheezing. PMID: 31600771 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 10, 2019 Category: Pediatrics Authors: Sastre B, García-García ML, Calvo C, Casas I, Rodrigo-Muñoz JM, Cañas JA, Mora I, Del Pozo V Tags: Pediatr Res Source Type: research

Toward precision medicine in pediatric population using cytochrome P450 phenotyping approaches and physiologically based pharmacokinetic modeling.
Abstract The activity of drug-metabolizing enzymes (DME) shows high inter- and intra-individual variability. Genetic polymorphisms, exposure to drugs, and environmental toxins are known to significantly alter DME expression. In addition, the activity of these enzymes is highly age-dependent due to maturation processes that occur during development. Currently, there is a vast choice of phenotyping methods in adults using exogenous probes to characterize the activity of these enzymes. However, this can hardly be applied to children since it requires the intake of non-therapeutic xenobiotics. In addition, sampling ma...
Source: Pediatric Research - October 10, 2019 Category: Pediatrics Authors: Magliocco G, Rodieux F, Desmeules J, Samer CF, Daali Y Tags: Pediatr Res Source Type: research

Neonatal frontal lobe: sonographic reference values and suggested clinical use.
CONCLUSIONS: Head ultrasound provides a simple, non-invasive method for measuring the thickness of the frontal lobe, which grows significantly between 24 and 40 weeks' gestation. In premature infants with PHHC, we suggest the use of the FL-CVT measure, in addition to ventricular size measures, as a direct assessment of the impact of the enlarged ventricles on the surrounding brain parenchyma. This could assist in the management of PHHC and determine the need and optimal timing for intervention. PMID: 31600773 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 10, 2019 Category: Pediatrics Authors: Borenstein-Levin L, Makhoul S, Ilivitzki A, Zreik M, Hochwald O, Makhoul JS, Kugelman A, Makhoul IR Tags: Pediatr Res Source Type: research

Defining and distinguishing infant behavioral states using acoustic cry analysis: is colic painful?
Abstract BACKGROUND: To characterize acoustic features of an infant's cry and use machine learning to provide an objective measurement of behavioral state. To apply the algorithm to colic hypothesizing that these cries sound painful. STUDY DESIGN: Assessment of 1000 cries in a mobile app (ChatterBabyTM). Training an algorithm by evaluating>6000 acoustic features to predict whether infant cry was due to a pain (vaccinations, ear-piercings), fussy, or hunger states. Using the algorithm to predict the behavioral state of infants with reported colic. RESULTS: The algorithm was 90.7% accurate for identifyi...
Source: Pediatric Research - October 4, 2019 Category: Pediatrics Authors: Parga JJ, Lewin S, Lewis J, Montoya-Williams D, Alwan A, Shaul B, Han C, Bookheimer SY, Eyer S, Dapretto M, Zeltzer L, Dunlap L, Nookala U, Sun D, Dang BH, Anderson AE Tags: Pediatr Res Source Type: research

Bronchiolitis severity is related to recurrent wheezing by age 3 years in a prospective, multicenter cohort.
PMID: 31585458 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 4, 2019 Category: Pediatrics Authors: Mansbach JM, Hasegawa K, Geller RJ, Espinola JA, Sullivan AF, Camargo CA, MARC-35 Investigators Tags: Pediatr Res Source Type: research

"Following through": addressing the racial inequality for preterm infants and their families.
"Following through": addressing the racial inequality for preterm infants and their families. Pediatr Res. 2019 Oct 03;: Authors: Stevenson DK, Wong RJ, Profit J, Shaw GM, Jason Wang C, Lee HC PMID: 31581171 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 3, 2019 Category: Pediatrics Authors: Stevenson DK, Wong RJ, Profit J, Shaw GM, Jason Wang C, Lee HC Tags: Pediatr Res Source Type: research

Review of bilirubin neurotoxicity II: preventing and treating acute bilirubin encephalopathy and kernicterus spectrum disorders.
Abstract Previously in Part I of this two-part review, we discussed the current and recent advances in the understanding of the molecular biology and neuropathology of bilirubin neurotoxicity (BNTx). Here in Part II, we summarize current treatment options available to treat the severely jaundiced infants to prevent significant brain damage and improve clinical outcomes. In addition, we review potential novel therapies that are in various stages of research and development. We will emphasize treatments for both prevention and treatment of both acute bilirubin encephalopathy (ABE) and kernicterus spectrum disorders ...
Source: Pediatric Research - October 3, 2019 Category: Pediatrics Authors: Shapiro SM, Riordan SM Tags: Pediatr Res Source Type: research

Rheumatological manifestations in inborn errors of immunity.
n S Abstract Rare monogenetic diseases serve as natural models to dissect the molecular pathophysiology of the complex disease traits. Rheumatologic disorders by nature are considered complex diseases with partially genetic origin, as exemplified by their heterogeneous phenotypic and genetic presentation. Recent advances in genetic technologies have helped uncover multiple variants associated with disease susceptibility; however, the genotype-phenotype link is still missing. Inborn errors of immunity (IEI) in addition to recurrent infections also present with autoimmune and autoinflammatory rheumatologic manifesta...
Source: Pediatric Research - October 3, 2019 Category: Pediatrics Authors: Bal SK, Pazmandi J, Boztug K, Özen S Tags: Pediatr Res Source Type: research

Increased expression of heme oxygenase-1 suppresses airway branching morphogenesis in fetal mouse lungs exposed to inflammation.
CONCLUSION: The ablation of Bach1 suppresses airway branching morphogenesis after LPS exposure by increased basal expression levels of HO-1. PMID: 31578032 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 2, 2019 Category: Pediatrics Authors: Arai Y, Ito M, Tanaka K, Ozawa J, Motojima Y, Matsuoka K, Igarashi K, Namba F Tags: Pediatr Res Source Type: research

Blood pressure extremes and severe IVH in preterm infants.
CONCLUSIONS: Infants who developed severe IVH had substantially more unstable MABP and spent a significantly greater period of time with MABP outside of the optimal range. PMID: 31578033 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 2, 2019 Category: Pediatrics Authors: Vesoulis ZA, Flower AA, Zanelli S, Rambhia A, Abubakar M, Whitehead HV, Fairchild KD, Mathur AM Tags: Pediatr Res Source Type: research

Cyclic AMP in human preterm infant blood is associated with increased TLR-mediated production of acute-phase and anti-inflammatory cytokines in vitro.
AJ Abstract BACKGROUND: Preterm infants are at high risk of infection and have distinct pathogen recognition responses. Suggested mechanisms include soluble mediators that enhance cellular levels of cAMP. OBJECTIVE: To assess the relationship between blood cAMP concentrations and TLR-mediated cytokine production in infants during the first month of life. METHODS: Cord and serial peripheral blood samples (days of life 1-28) were obtained from a cohort of very preterm (
Source: Pediatric Research - October 2, 2019 Category: Pediatrics Authors: Strunk T, van Haren SD, Hibbert J, Pettengill M, Ozonoff A, Jans J, Schüller SS, Burgner D, Levy O, Currie AJ Tags: Pediatr Res Source Type: research

Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia.
CONCLUSION: This study indicates that 2-iminobiotin is well tolerated and not associated with any adverse events in neonates treated with therapeutic hypothermia after perinatal asphyxia. Target exposure was achieved with eight doses of 0.08 mg/kg q6h. Optimal duration of therapy for clinical efficacy needs to be determined in future clinical trials. PMID: 31578035 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 2, 2019 Category: Pediatrics Authors: Favié LMA, Peeters-Scholte CMPCD, Bakker A, Tjabbes H, Egberts TCG, van Bel F, Rademaker CMA, Vis P, Groenendaal F Tags: Pediatr Res Source Type: research

Prenatal second-hand smoke exposure and newborn telomere length.
CONCLUSIONS: This study demonstrated that prenatal second-hand smoke exposure may be a preventable risk factor for accelerated biological aging in the intrauterine stage, and further suggested possible sex differences in the susceptibility to prenatal second-hand smoke. PMID: 31578036 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 2, 2019 Category: Pediatrics Authors: Liu B, Song L, Zhang L, Wu M, Wang L, Cao Z, Xiong C, Zhang B, Li Y, Xia W, Xu S, Wang Y Tags: Pediatr Res Source Type: research

Evaluation of administrative case definitions for chronic kidney disease in children.
Abstract INTRODUCTION: Administrative data is increasingly used for chronic disease surveillance; however, its validity to define cases of chronic kidney disease (CKD) in children is unknown. We sought to evaluate the performance of case definitions for CKD in children. METHODS: We utilized population-based administrative data from the Manitoba Center for Health Policy to evaluate the validity of algorithms based on a combination of hospital claims, outpatient physician visits, and pharmaceutical use over 1-3 years in children
Source: Pediatric Research - October 2, 2019 Category: Pediatrics Authors: Dart A, Chartier M, Komenda P, Walld R, Koseva I, Burchill C, Tangri N Tags: Pediatr Res Source Type: research

Privacy-protecting multivariable-adjusted distributed regression analysis for multi-center pediatric study.
Abstract BACKGROUND: Privacy-protecting analytic approaches without centralized pooling of individual-level data, such as distributed regression, are particularly important for vulnerable populations, such as children, but these methods have not yet been tested in multi-center pediatric studies. METHODS: Using the electronic health data from 34 healthcare institutions in the National Patient-Centered Clinical Research Network (PCORnet), we fit 12 multivariable-adjusted linear regression models to assess the associations of antibiotic use
Source: Pediatric Research - October 2, 2019 Category: Pediatrics Authors: Toh S, Rifas-Shiman SL, Lin PI, Bailey LC, Forrest CB, Horgan CE, Lunsford D, Moyneur E, Sturtevant JL, Young JG, Block JP, PCORnet Antibiotics and Childhood Growth Study Group Tags: Pediatr Res Source Type: research

Short- and long-term impact of hyperoxia on the blood and retinal cells' transcriptome in a mouse model of oxygen-induced retinopathy.
CONCLUSION: There are sustained marked changes in the global pattern of gene expression in the OIR mice retinas. An altered expression of Deptor and Nol4 genes in the blood mononuclear cells requires further investigation as they may indicate retinal neovascularization. PMID: 31578039 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 2, 2019 Category: Pediatrics Authors: Zasada M, Madetko-Talowska A, Revhaug C, Rognlien AGW, Baumbusch LO, Książek T, Szewczyk K, Grabowska A, Bik-Multanowski M, Józef Pietrzyk J, Kwinta P, Didrik Saugstad O Tags: Pediatr Res Source Type: research

Salivary cortisol levels as a biomarker for severity of withdrawal in opioid-exposed newborns.
CONCLUSIONS: Salivary cortisol in opioid-exposed newborns may provide an index of stress and help identify infants who will have more severe clinical presentation of NAS. Such a biomarker would allow risk stratification for early treatment and discharge decisions. PMID: 31578040 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 2, 2019 Category: Pediatrics Authors: Rodriguez N, Vining M, Bloch-Salisbury E Tags: Pediatr Res Source Type: research

A Gunn rat model of preterm hyperbilirubinemia.
DISCUSSION: The Gunn rat pup model may be a good model to study hyperbilirubinemia in preterm infants. PMID: 31578041 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 2, 2019 Category: Pediatrics Authors: Waddell J, He M, Tang N, Rizzuto C, Bearer CF Tags: Pediatr Res Source Type: research

A pediatric perspective on genomics and prevention in the twenty-first century.
We present evidence from diverse disciplines and populations to identify the current and emerging role of genomics in prevention from both medical and public health perspectives as well as key challenges and potential untoward consequences of increasing the role of genomics in these endeavors. We begin by comparing screening in healthy populations (newborn screening), with testing in symptomatic populations, which may incidentally identify secondary findings and at-risk relatives. Emerging evidence suggests that variants in genes subject to the reporting of secondary findings are more common than expected in patients who o...
Source: Pediatric Research - October 2, 2019 Category: Pediatrics Authors: Chaudhari BP, Manickam K, McBride KL Tags: Pediatr Res Source Type: research

Head circumference at birth and intellectual disability: a nationwide cohort study.
CONCLUSIONS: Intrauterine brain growth restriction may be a risk factor for ID. PMID: 31578043 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - October 2, 2019 Category: Pediatrics Authors: Aagaard K, Matthiesen NB, Bach CC, Larsen RT, Henriksen TB Tags: Pediatr Res Source Type: research

Higher chocolate intake is associated with longer telomere length among adolescents.
Abstract BACKGROUND: Chocolate intake has shown cardiometabolic health benefits. Whether chocolate has any effect on cellular aging remains unknown. We aimed to test the hypothesis that higher chocolate intake is associated with longer leukocyte telomere length (LTL) in adolescents. METHODS: A total of 660 adolescents (aged 14-18 years) were included in the analysis. The chocolate intake was assessed by 7-day, 24-h dietary recalls and split into three groups, which were none,
Source: Pediatric Research - October 1, 2019 Category: Pediatrics Authors: Chen L, Zhu H, Gutin B, Sesso HD, Dong Y Tags: Pediatr Res Source Type: research

Early career investigator highlight.
PMID: 31554008 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 25, 2019 Category: Pediatrics Authors: Berens A Tags: Pediatr Res Source Type: research

Clinical quantification of SpO2 instability using a new histogram classification system: a clinical study.
Abstract BACKGROUND: Oxygenation instability is not quantified or documented despite being common and correlated with neonatal morbidities, retinopathy of prematurity, and adverse 18-month outcomes. METHODS: We developed a five-type SpO2 histogram classification system based on the SpO2 difference within the 10-90th cumulative time percentile (A) and the time percentage with SpO2 ≤80% (B). In type 1, A is
Source: Pediatric Research - September 20, 2019 Category: Pediatrics Authors: Borenstein-Levin L, Konikoff L, Solimano A Tags: Pediatr Res Source Type: research

The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group.
Abstract BACKGROUND: We evaluated the epidemiology of fluid balance (FB) over the first postnatal week and its impact on outcomes in a multi-center cohort of premature neonates from the AWAKEN study. METHODS: Retrospective analysis of infants
Source: Pediatric Research - September 19, 2019 Category: Pediatrics Authors: Selewski DT, Gist KM, Nathan AT, Goldstein SL, Boohaker LJ, Akcan-Arikan A, Bonachea EM, Hanna M, Joseph C, Mahan JD, Mammen C, Nada A, Reidy K, Staples A, Wintermark P, Griffin R, Askenazi DJ, Guillet R, Neonatal Kidney Collaborative Tags: Pediatr Res Source Type: research

The developing gut-lung axis: postnatal growth restriction, intestinal dysbiosis, and pulmonary hypertension in a rodent model.
CONCLUSION: PNGR causes intestinal dysbiosis and PH. Treatment with DSM 17938 prevents PNGR-associated RVH and PH. Changes in the developing intestine and intestinal microbiota impact the developing lung vasculature and RV. PMID: 31537010 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 19, 2019 Category: Pediatrics Authors: Wedgwood S, Warford C, Agvatisiri SR, Thai PN, Chiamvimonvat N, Kalanetra KM, Lakshminrusimha S, Steinhorn RH, Mills DA, Underwood MA Tags: Pediatr Res Source Type: research

Defining pediatric community-acquired acute kidney injury: an observational study.
CONCLUSIONS: Age- and gender-based creatinine norms can be applied as a surrogate baseline to detect CA-AKI in all children regardless of whether baseline creatinine is available, potentially detecting it earlier. PMID: 31537011 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 19, 2019 Category: Pediatrics Authors: O'Neil ER, Devaraj S, Mayorquin L, Starke HE, Buffone GJ, Loftis LL, Arikan AA, Cruz AT Tags: Pediatr Res Source Type: research

The postnatal presence of human chorionic gonadotropin in preterm infants and its potential inverse association with retinopathy of prematurity.
CONCLUSIONS: We found that hCG is present postnatally in preterm infants and that a deficiency of hCG at 4 weeks of age is potentially associated with non-proliferative ROP. This provides novel evidence to suggest that hCG may participate in human retinal angiogenesis. PMID: 31537012 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 19, 2019 Category: Pediatrics Authors: Movsas TZ, Paneth N, Gewolb IH, Lu Q, Cavey G, Muthusamy A Tags: Pediatr Res Source Type: research

A perfect storm: fetal inflammation and the developing immune system.
Abstract Histologic chorioamnionitis is an inflammatory disorder of the placenta that commonly precedes preterm delivery. Preterm birth related to chorioamnionitis and fetal inflammation has been associated with a risk for serious inflammatory complications in infancy. In addition, preterm infants exposed to chorioamnionitis may be more susceptible to infection in the neonatal intensive care unit and possibly later in life. A significant body of work has established an association between chorioamnionitis and inflammatory processes. However, the potential consequences of this inflammation on postnatal immunity are...
Source: Pediatric Research - September 19, 2019 Category: Pediatrics Authors: Sabic D, Koenig JM Tags: Pediatr Res Source Type: research

Correction: Mediators of racial and ethnic disparity in mother's own milk feeding in very low birth weight infants.
Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper. PMID: 31534188 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 18, 2019 Category: Pediatrics Authors: Patel AL, Schoeny ME, Hoban R, Johnson TJ, Bigger H, Engstrom JL, Fleurant E, Riley B, Meier PP Tags: Pediatr Res Source Type: research

Toward the elimination of bias in Pediatric Research.
Gunn A, Gressens P, Guissani D, Haiden N, Hauptman M, Kim KS, Klebanoff M, Lachman P, Lanphear B, Ozen S, Roehr C, Roland D, Rosenblum N, Schwarz M, Staiano A, Stroustrup A, Valente EM, Wilson-Costello D, Wynn J, Molloy E PMID: 31533126 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 18, 2019 Category: Pediatrics Authors: Bearer C, Agostoni C, Anand KJS, Ambalavanan N, Bhandari V, Bliss JM, Bloomfield F, Bonifacio SL, Buhimschi I, Cilio MR, Coppes M, Czinn SJ, El-Khuffash A, Embleton N, Felderhoff-Müser U, Ferriero DM, Florin T, Fuentes-Afflick E, Gardner W, Gospe SM, Gun Tags: Pediatr Res Source Type: research

3rd Congress of Joint European Neonatal Societies (jENS 2019).
Authors: PMID: 31530898 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 17, 2019 Category: Pediatrics Tags: Pediatr Res Source Type: research

Insights Image for "Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats".
Insights Image for "Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats". Pediatr Res. 2019 Sep 14;: Authors: van den Hoogen NJ, Patijn J, Tibboel D, Joosten EAJ PMID: 31521059 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 14, 2019 Category: Pediatrics Authors: van den Hoogen NJ, Patijn J, Tibboel D, Joosten EAJ Tags: Pediatr Res Source Type: research

The rewards of peer-reviewing.
PMID: 31521060 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 14, 2019 Category: Pediatrics Authors: Bearer CF, Chalak L, Fuentes-Afflick E, Molloy EJ Tags: Pediatr Res Source Type: research

Understanding positive child health.
PMID: 31521061 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 14, 2019 Category: Pediatrics Authors: Bangma JT, Kwiatkowski E, Psioda M, Santos HP, Hooper SR, Douglass L, Joseph RM, Frazier JA, Kuban KCK, O'Shea TM, Fry RC, ELGAN Investigators Tags: Pediatr Res Source Type: research

Global Child Health: beyond surviving to thriving.
PMID: 31499512 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 9, 2019 Category: Pediatrics Authors: Cheng TL, Shilkofski N, Pediatric Policy Council Tags: Pediatr Res Source Type: research

Spectrum of congenital anomalies among VACTERL cases: a EUROCAT population-based study.
CONCLUSION: The clearly defined VACTERL component features and the VACTERL subtypes introduced will improve both clinical practice and etiologic research. PMID: 31499513 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 9, 2019 Category: Pediatrics Authors: van de Putte R, van Rooij IALM, Marcelis CLM, Guo M, Brunner HG, Addor MC, Cavero-Carbonell C, Dias CM, Draper ES, Etxebarriarteun L, Gatt M, Haeusler M, Khoshnood B, Klungsoyr K, Kurinczuk JJ, Lanzoni M, Latos-Bielenska A, Luyt K, O'Mahony MT, Miller N, Tags: Pediatr Res Source Type: research

Hyaluronan 35  kDa enhances epithelial barrier function and protects against the development of murine necrotizing enterocolitis.
CONCLUSION: These findings suggest that HA 35 protects against NEC partly by upregulating intestinal TJs and enhancing intestinal barrier function. PMID: 31499514 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 9, 2019 Category: Pediatrics Authors: Gunasekaran A, Eckert J, Burge K, Zheng W, Yu Z, Kessler S, de la Motte C, Chaaban H Tags: Pediatr Res Source Type: research

Reduced brain mammillary body volumes and memory deficits in adolescents who have undergone the Fontan procedure.
CONCLUSION: Adolescents with SVHD show reduced MB volumes associated with cognitive/memory deficits. Potential mechanisms of volume losses may include developmental and/or hypoxic/ischemic-induced processes. Providers should screen for cognitive deficits and explore possible interventions to improve memory. PMID: 31499515 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 9, 2019 Category: Pediatrics Authors: Cabrera-Mino C, Roy B, Woo MA, Singh S, Moye S, Halnon NJ, Lewis AB, Kumar R, Pike NA Tags: Pediatr Res Source Type: research

Eye-tracking during simulation-based neonatal airway management.
This study was an observational simulation-based study. The team member assigned to airway management wore head-mounted eye-tracking glasses. Main outcome measures were airway providers' gaze, dwell time (total amount of time a participant fixates), and usability of eye-tracking glasses. RESULTS: Data from 13 participants were included. There were significant differences in dwell time (total amount of time a participant fixates certain areas of interest) during the scenario (p 
Source: Pediatric Research - September 9, 2019 Category: Pediatrics Authors: Wagner M, Groepel P, Bibl K, Olischar M, Auerbach MA, Gross IT Tags: Pediatr Res Source Type: research

Magnesium sulfate inhibits inflammation through P2X7 receptors in human umbilical vein endothelial cells.
CONCLUSION: LPS-exposure increases IL-1β production and secretion in HUVECs, which is further intensified by P2X7R agonist, BzATP while MgSO4 inhibits IL-1β in both presence and absence of BzATP. This effect is similar to the results of P2X7R antagonist, BBG, suggesting that the anti-inflammatory effects of MgSO4 is through P2X7R. PMID: 31493768 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - September 7, 2019 Category: Pediatrics Authors: Ozen M, Xie H, Shin N, Al Yousif G, Clemens J, McLane MW, Lei J, Burd I Tags: Pediatr Res Source Type: research