The structure of occupational diseases in first-third-year piano students
CONCLUSIONS: The research results indicate that the main occupational diseases of piano students are those related to hands and muscular system.IMPACT: The obtained data suggest that the range of diseases is likely to progress throughout the musical training. The main diseases of piano students are those related to hands and muscular system. The sharpest rise was during the transition from the 2nd to the 3rd year of study.PMID:35079110 | DOI:10.1038/s41390-021-01921-9 (Source: Pediatric Research)
Source: Pediatric Research - January 26, 2022 Category: Pediatrics Authors: Hainan Zhang Source Type: research

Approaching the diagnosis of thyroid disorders in preterm infants
Pediatr Res. 2022 Jan 25. doi: 10.1038/s41390-022-01951-x. Online ahead of print.NO ABSTRACTPMID:35079111 | DOI:10.1038/s41390-022-01951-x (Source: Pediatric Research)
Source: Pediatric Research - January 26, 2022 Category: Pediatrics Authors: Francisca Grob Source Type: research

Successful delivery room management of electromechanical dissociation and heart block: is electrocardiogram useless?
Pediatr Res. 2022 Jan 25. doi: 10.1038/s41390-022-01953-9. Online ahead of print.NO ABSTRACTPMID:35079112 | DOI:10.1038/s41390-022-01953-9 (Source: Pediatric Research)
Source: Pediatric Research - January 26, 2022 Category: Pediatrics Authors: Cristina Cortes Eva Vierge Enrique Criado Jose Martinez-Orgado Luis Arruza Source Type: research

The association between hypertensive disorders of pregnancy and childhood asthma
CONCLUSIONS: In conclusion, children exposed to HDP may be at increased odds of asthma diagnosis by age seven, particularly if they were born preterm or SGA.IMPACT: There is a paucity of data investigating the relationship between hypertensive disorders of pregnancy and childhood asthma, with recent studies showing conflicting results. Our study investigated this relationship using a large cohort with ample information on a wide range of confounding factors. Our study showed that individuals exposed to HDP may be at increased odds of asthma diagnosis by age seven years, particularly if they were also born SGA or preterm.PM...
Source: Pediatric Research - January 26, 2022 Category: Pediatrics Authors: Louise Kelly Peter Barrett Fergus P McCarthy Gerard W O'Keeffe Gillian M Maher Ali S Khashan Source Type: research

Understanding the hematopoietic factory during acute lymphoblastic leukemia
Pediatr Res. 2022 Jan 25. doi: 10.1038/s41390-022-01957-5. Online ahead of print.NO ABSTRACTPMID:35079114 | DOI:10.1038/s41390-022-01957-5 (Source: Pediatric Research)
Source: Pediatric Research - January 26, 2022 Category: Pediatrics Authors: Kara L Davis Source Type: research

Predictive characteristics to discriminate the longitudinal outcomes of childhood asthma: a retrospective program-based study
CONCLUSIONS: We showed that the risk for adverse clinical outcomes at follow-up differed between serum IgE, blood eosinophil, and allergen sensitization identified at baseline. Sensitization and ICS dosage were predictive characteristics of long-term clinical outcomes.IMPACT: The unique aspects of the study are its longitudinal assessment of patients receiving guideline-based asthma management program to help characterize the stability of the clinical outcomes over time. Characteristics including allergen sensitization and ICS dosage demonstrated an improved capability for distinguishing between better and worse clinical o...
Source: Pediatric Research - January 25, 2022 Category: Pediatrics Authors: Jyh-Hong Lee Yu-Tsan Lin Ai-Lin Chu Shu-Ya Hsiao Kuei-Ying Chang Yao-Hsu Yang Li-Chieh Wang Hsin-Hui Yu Ya-Chiao Hu Bor-Luen Chiang Source Type: research

Predictive characteristics to discriminate the longitudinal outcomes of childhood asthma: a retrospective program-based study
CONCLUSIONS: We showed that the risk for adverse clinical outcomes at follow-up differed between serum IgE, blood eosinophil, and allergen sensitization identified at baseline. Sensitization and ICS dosage were predictive characteristics of long-term clinical outcomes.IMPACT: The unique aspects of the study are its longitudinal assessment of patients receiving guideline-based asthma management program to help characterize the stability of the clinical outcomes over time. Characteristics including allergen sensitization and ICS dosage demonstrated an improved capability for distinguishing between better and worse clinical o...
Source: Pediatric Research - January 25, 2022 Category: Pediatrics Authors: Jyh-Hong Lee Yu-Tsan Lin Ai-Lin Chu Shu-Ya Hsiao Kuei-Ying Chang Yao-Hsu Yang Li-Chieh Wang Hsin-Hui Yu Ya-Chiao Hu Bor-Luen Chiang Source Type: research

Which corticosteroid is a better option for antenatal fetal lung maturation?
Pediatr Res. 2022 Jan 21. doi: 10.1038/s41390-022-01948-6. Online ahead of print.NO ABSTRACTPMID:35064232 | DOI:10.1038/s41390-022-01948-6 (Source: Pediatric Research)
Source: Pediatric Research - January 22, 2022 Category: Pediatrics Authors: Sedigheh Hantoushzadeh Maasoumeh Saleh Sepehr Aghajanian Source Type: research

Which corticosteroid is a better option for antenatal fetal lung maturation?
Pediatr Res. 2022 Jan 21. doi: 10.1038/s41390-022-01948-6. Online ahead of print.NO ABSTRACTPMID:35064232 | DOI:10.1038/s41390-022-01948-6 (Source: Pediatric Research)
Source: Pediatric Research - January 22, 2022 Category: Pediatrics Authors: Sedigheh Hantoushzadeh Maasoumeh Saleh Sepehr Aghajanian Source Type: research

Which corticosteroid is a better option for antenatal fetal lung maturation?
Pediatr Res. 2022 Jan 21. doi: 10.1038/s41390-022-01948-6. Online ahead of print.NO ABSTRACTPMID:35064232 | DOI:10.1038/s41390-022-01948-6 (Source: Pediatric Research)
Source: Pediatric Research - January 22, 2022 Category: Pediatrics Authors: Sedigheh Hantoushzadeh Maasoumeh Saleh Sepehr Aghajanian Source Type: research

Looking back at the neonatal period in early-treated phenylketonuric patients
Pediatr Res. 2022 Jan 20. doi: 10.1038/s41390-022-01937-9. Online ahead of print.NO ABSTRACTPMID:35058603 | DOI:10.1038/s41390-022-01937-9 (Source: Pediatric Research)
Source: Pediatric Research - January 21, 2022 Category: Pediatrics Authors: Vincenzo Leuzzi Francesca Nardecchia Source Type: research

Observational study of birth outcomes in children with inborn errors of metabolism
CONCLUSIONS: Children with inborn errors of metabolism, whether detected at birth or later, are at high risk of adverse birth outcomes and congenital anomalies.IMPACT: Inborn errors of metabolism may affect fetal development, but the association with adverse birth outcomes is not well characterized. This study indicates that children with inborn errors of metabolism are at risk of preterm birth, neonatal jaundice, congenital anomalies, and a range of other adverse birth outcomes. Mothers of children with inborn errors of metabolism are at risk of preeclampsia and cesarean delivery. Adverse birth outcomes may be a first sig...
Source: Pediatric Research - January 21, 2022 Category: Pediatrics Authors: Nathalie Auger Marianne Bilodeau-Bertrand Émilie Brousseau Chantal Nelson Laura Arbour Source Type: research

Paediatric and neonatal sepsis and inflammation
Pediatr Res. 2022 Jan 19:1-3. doi: 10.1038/s41390-021-01918-4. Online ahead of print.ABSTRACTSepsis has a huge impact on global mortality and has been declared as a priority by the World Health organisation the WHO.1 Children have a high incidence of sepsis especially in the neonatal with an estimated 3 million babies affected worldwide and mortality ranges from 11 to 19%.2 In addition, long-term neurodevelopmental outcomes are affected but this is largely unquantified. However, challenges remain in the early recognition, diagnosis and standardised management of sepsis. This series on Sepsis and inflammation in children re...
Source: Pediatric Research - January 20, 2022 Category: Pediatrics Authors: E J Molloy C F Bearer Source Type: research

The willingness to risk failure
Pediatr Res. 2022 Jan 19. doi: 10.1038/s41390-022-01938-8. Online ahead of print.NO ABSTRACTPMID:35046542 | DOI:10.1038/s41390-022-01938-8 (Source: Pediatric Research)
Source: Pediatric Research - January 20, 2022 Category: Pediatrics Authors: Cynthia F Bearer Eleanor J Molloy Source Type: research

Epigenetic insights into the pathogenesis of Kawasaki disease
Pediatr Res. 2022 Jan 19. doi: 10.1038/s41390-021-01925-5. Online ahead of print.NO ABSTRACTPMID:35046543 | DOI:10.1038/s41390-021-01925-5 (Source: Pediatric Research)
Source: Pediatric Research - January 20, 2022 Category: Pediatrics Authors: Shuichi Ito Sayaka Fukuda Tohru Kobayashi Source Type: research

Paediatric and neonatal sepsis and inflammation
Pediatr Res. 2022 Jan 19. doi: 10.1038/s41390-021-01918-4. Online ahead of print.ABSTRACTSepsis has a huge impact on global mortality and has been declared as a priority by the World Health organisation the WHO.1 Children have a high incidence of sepsis especially in the neonatal with an estimated 3 million babies affected worldwide and mortality ranges from 11 to 19%.2 In addition, long-term neurodevelopmental outcomes are affected but this is largely unquantified. However, challenges remain in the early recognition, diagnosis and standardised management of sepsis. This series on Sepsis and inflammation in children review...
Source: Pediatric Research - January 20, 2022 Category: Pediatrics Authors: E J Molloy C F Bearer Source Type: research

The willingness to risk failure
Pediatr Res. 2022 Jan 19. doi: 10.1038/s41390-022-01938-8. Online ahead of print.NO ABSTRACTPMID:35046542 | DOI:10.1038/s41390-022-01938-8 (Source: Pediatric Research)
Source: Pediatric Research - January 20, 2022 Category: Pediatrics Authors: Cynthia F Bearer Eleanor J Molloy Source Type: research

Epigenetic insights into the pathogenesis of Kawasaki disease
Pediatr Res. 2022 Jan 19. doi: 10.1038/s41390-021-01925-5. Online ahead of print.NO ABSTRACTPMID:35046543 | DOI:10.1038/s41390-021-01925-5 (Source: Pediatric Research)
Source: Pediatric Research - January 20, 2022 Category: Pediatrics Authors: Shuichi Ito Sayaka Fukuda Tohru Kobayashi Source Type: research

No infectious SARS-CoV-2 in breast milk from a cohort of 110 lactating women
CONCLUSIONS: SARS-CoV-2 RNA can be found infrequently in the breastmilk after recent infection, but we found no evidence that breastmilk contains an infectious virus or that breastfeeding represents a risk factor for transmission of infection to infants.IMPACT: This article goes beyond prior small studies to provide evidence that infectious SARS-CoV-2 is not present in the milk of lactating women with recent infection, even when SARS-CoV-2 RNA is detected. Recent SARS-CoV-2 infection or detection of its RNA in human milk is not a contraindication to breastfeeding.PMID:35042956 | DOI:10.1038/s41390-021-01902-y (Source: Pediatric Research)
Source: Pediatric Research - January 19, 2022 Category: Pediatrics Authors: Paul Krogstad Deisy Contreras Hwee Ng Nicole Tobin Christina D Chambers Kerri Bertrand Lars Bode Grace M Aldrovandi Source Type: research

Development of the immune system in the human embryo
Pediatr Res. 2022 Jan 18. doi: 10.1038/s41390-022-01940-0. Online ahead of print.ABSTRACTThe fetal immune system is highly specialized which is to generate both tolerogenic and protective immune responses to tolerate both self- and maternal-antigens. Fetal T cells with pro-inflammatory potential are born in a tolerogenic environment and are tightly controlled by both cell-intrinsic and -extrinsic mechanisms. Fetal B-1 and B-2 B cells involved in innate and adaptive immune responses, respectively, arise in staggered waves of development from distinct progenitors. Innate immune responses are the key to the protection against...
Source: Pediatric Research - January 19, 2022 Category: Pediatrics Authors: Zakir Hossain A H M Mohsinul Reza Wafaa A Qasem James K Friel Abdelwahab Omri Source Type: research

No infectious SARS-CoV-2 in breast milk from a cohort of 110 lactating women
CONCLUSIONS: SARS-CoV-2 RNA can be found infrequently in the breastmilk after recent infection, but we found no evidence that breastmilk contains an infectious virus or that breastfeeding represents a risk factor for transmission of infection to infants.IMPACT: This article goes beyond prior small studies to provide evidence that infectious SARS-CoV-2 is not present in the milk of lactating women with recent infection, even when SARS-CoV-2 RNA is detected. Recent SARS-CoV-2 infection or detection of its RNA in human milk is not a contraindication to breastfeeding.PMID:35042956 | DOI:10.1038/s41390-021-01902-y (Source: Pediatric Research)
Source: Pediatric Research - January 19, 2022 Category: Pediatrics Authors: Paul Krogstad Deisy Contreras Hwee Ng Nicole Tobin Christina D Chambers Kerri Bertrand Lars Bode Grace M Aldrovandi Source Type: research

Development of the immune system in the human embryo
Pediatr Res. 2022 Jan 18. doi: 10.1038/s41390-022-01940-0. Online ahead of print.ABSTRACTThe fetal immune system is highly specialized which is to generate both tolerogenic and protective immune responses to tolerate both self- and maternal-antigens. Fetal T cells with pro-inflammatory potential are born in a tolerogenic environment and are tightly controlled by both cell-intrinsic and -extrinsic mechanisms. Fetal B-1 and B-2 B cells involved in innate and adaptive immune responses, respectively, arise in staggered waves of development from distinct progenitors. Innate immune responses are the key to the protection against...
Source: Pediatric Research - January 19, 2022 Category: Pediatrics Authors: Zakir Hossain A H M Mohsinul Reza Wafaa A Qasem James K Friel Abdelwahab Omri Source Type: research

Correction to: Validation of published rebound hyperbilirubinemia risk prediction scores during birth hospitalization after initial phototherapy: a retrospective chart review
Pediatr Res. 2022 Jan 17. doi: 10.1038/s41390-021-01858-z. Online ahead of print.NO ABSTRACTPMID:35039602 | DOI:10.1038/s41390-021-01858-z (Source: Pediatric Research)
Source: Pediatric Research - January 18, 2022 Category: Pediatrics Authors: Vincent So Helen Coo Faiza Khurshid Source Type: research

Thromboembolism in children with multisystem inflammatory syndrome: a literature review
Pediatr Res. 2022 Jan 14:1-5. doi: 10.1038/s41390-021-01873-0. Online ahead of print.ABSTRACTMultisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory response observed in children several weeks to months after acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). On review of all published cases of thromboembolism (TE) as a complication of MIS-C, 33 cases of TE were found with incidence ranging from 1.4 to 6.5%. TE occurred mostly in children aged 12 years and above. One-third of the cases were cerebral infarcts and the remaining cases included intracardiac and radial arteri...
Source: Pediatric Research - January 15, 2022 Category: Pediatrics Authors: Neethu M Menon Lakshmi V Srivaths Source Type: research

Thromboembolism in children with multisystem inflammatory syndrome: a literature review
Pediatr Res. 2022 Jan 14:1-5. doi: 10.1038/s41390-021-01873-0. Online ahead of print.ABSTRACTMultisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory response observed in children several weeks to months after acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). On review of all published cases of thromboembolism (TE) as a complication of MIS-C, 33 cases of TE were found with incidence ranging from 1.4 to 6.5%. TE occurred mostly in children aged 12 years and above. One-third of the cases were cerebral infarcts and the remaining cases included intracardiac and radial arteri...
Source: Pediatric Research - January 15, 2022 Category: Pediatrics Authors: Neethu M Menon Lakshmi V Srivaths Source Type: research

Thromboembolism in children with multisystem inflammatory syndrome: a literature review
Pediatr Res. 2022 Jan 14. doi: 10.1038/s41390-021-01873-0. Online ahead of print.ABSTRACTMultisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory response observed in children several weeks to months after acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). On review of all published cases of thromboembolism (TE) as a complication of MIS-C, 33 cases of TE were found with incidence ranging from 1.4 to 6.5%. TE occurred mostly in children aged 12 years and above. One-third of the cases were cerebral infarcts and the remaining cases included intracardiac and radial arterial t...
Source: Pediatric Research - January 15, 2022 Category: Pediatrics Authors: Neethu M Menon Lakshmi V Srivaths Source Type: research

Value of children in our world
Pediatr Res. 2022 Jan 13. doi: 10.1038/s41390-021-01609-0. Online ahead of print.NO ABSTRACTPMID:35027680 | DOI:10.1038/s41390-021-01609-0 (Source: Pediatric Research)
Source: Pediatric Research - January 14, 2022 Category: Pediatrics Authors: Cynthia F Bearer Damian Roland Eleanor J Molloy Source Type: research

Value of children in our world
Pediatr Res. 2022 Jan 13. doi: 10.1038/s41390-021-01609-0. Online ahead of print.NO ABSTRACTPMID:35027680 | DOI:10.1038/s41390-021-01609-0 (Source: Pediatric Research)
Source: Pediatric Research - January 14, 2022 Category: Pediatrics Authors: Cynthia F Bearer Damian Roland Eleanor J Molloy Source Type: research

The context of background TV exposure and children's executive functioning
CONCLUSIONS: Reducing exposure can mitigate negative relations. This is an important goal as children are exposed to more of all forms of screen media during the COVID-19 pandemic. Results confirm the American Academy of Pediatrics' recommendation that TV be turned off in the background when a child is in the room.IMPACT: Young children are exposed to significant hours of background television per day across multiple contexts: socializing with family, playing alone or with others, engaging in routines/chores, eating/drinking, and sleeping. Most exposure (46%) occurred while sleeping. Sleep exposure predicted poorer executi...
Source: Pediatric Research - January 13, 2022 Category: Pediatrics Authors: Deborah L Nichols Source Type: research

Family reflections: parents and caregivers of people with FASD: what research do we need?
Pediatr Res. 2022 Jan 12. doi: 10.1038/s41390-021-01926-4. Online ahead of print.NO ABSTRACTPMID:35022558 | DOI:10.1038/s41390-021-01926-4 (Source: Pediatric Research)
Source: Pediatric Research - January 13, 2022 Category: Pediatrics Authors: Adrienne Ehlert Bashista Source Type: research

A specialized multi-disciplinary care program for children with sepsis and multiple organ dysfunction-associated immune dysregulation
Pediatr Res. 2022 Jan 12:1-6. doi: 10.1038/s41390-021-01891-y. Online ahead of print.ABSTRACTThe complex physiology and medical requirements of children with sepsis and multiple organ dysfunction syndrome (MODS) challenge traditional care coordination models. While the involvement of multiple clinical subspecialty services is often necessary to support different care processes and individual organ system dysfunctions, it can also delay the diagnostic process, monitoring, and treatment. The logistics of coordinating with many specialty providers for critically ill patients are challenging and time consuming, and often can r...
Source: Pediatric Research - January 13, 2022 Category: Pediatrics Authors: Lindsey R Swigart L Nelson Sanchez-Pinto Brian E Nolan Patrick C Seed Bria M Coates Source Type: research

The context of background TV exposure and children's executive functioning
CONCLUSIONS: Reducing exposure can mitigate negative relations. This is an important goal as children are exposed to more of all forms of screen media during the COVID-19 pandemic. Results confirm the American Academy of Pediatrics' recommendation that TV be turned off in the background when a child is in the room.IMPACT: Young children are exposed to significant hours of background television per day across multiple contexts: socializing with family, playing alone or with others, engaging in routines/chores, eating/drinking, and sleeping. Most exposure (46%) occurred while sleeping. Sleep exposure predicted poorer executi...
Source: Pediatric Research - January 13, 2022 Category: Pediatrics Authors: Deborah L Nichols Source Type: research

Family reflections: parents and caregivers of people with FASD: what research do we need?
Pediatr Res. 2022 Jan 12. doi: 10.1038/s41390-021-01926-4. Online ahead of print.NO ABSTRACTPMID:35022558 | DOI:10.1038/s41390-021-01926-4 (Source: Pediatric Research)
Source: Pediatric Research - January 13, 2022 Category: Pediatrics Authors: Adrienne Ehlert Bashista Source Type: research

A specialized multi-disciplinary care program for children with sepsis and multiple organ dysfunction-associated immune dysregulation
Pediatr Res. 2022 Jan 12. doi: 10.1038/s41390-021-01891-y. Online ahead of print.ABSTRACTThe complex physiology and medical requirements of children with sepsis and multiple organ dysfunction syndrome (MODS) challenge traditional care coordination models. While the involvement of multiple clinical subspecialty services is often necessary to support different care processes and individual organ system dysfunctions, it can also delay the diagnostic process, monitoring, and treatment. The logistics of coordinating with many specialty providers for critically ill patients are challenging and time consuming, and often can resul...
Source: Pediatric Research - January 13, 2022 Category: Pediatrics Authors: Lindsey R Swigart L Nelson Sanchez-Pinto Brian E Nolan Patrick C Seed Bria M Coates Source Type: research

Early spectral EEG in preterm infants correlates with neurocognitive outcomes in late childhood
This study is an observational prospective cohort study of premature infants with a gestational age
Source: Pediatric Research - January 11, 2022 Category: Pediatrics Authors: Tone Nordvik Eva M Schumacher P ål G Larsson Are H Pripp Gro C L øhaugen Tom Stiris Source Type: research

2020 and 2021 APS and SPR Award Winners
Pediatr Res. 2022 Jan 10. doi: 10.1038/s41390-021-01864-1. Online ahead of print.NO ABSTRACTPMID:35013564 | DOI:10.1038/s41390-021-01864-1 (Source: Pediatric Research)
Source: Pediatric Research - January 11, 2022 Category: Pediatrics Source Type: research

Early spectral EEG in preterm infants correlates with neurocognitive outcomes in late childhood
This study is an observational prospective cohort study of premature infants with a gestational age
Source: Pediatric Research - January 11, 2022 Category: Pediatrics Authors: Tone Nordvik Eva M Schumacher P ål G Larsson Are H Pripp Gro C L øhaugen Tom Stiris Source Type: research

2020 and 2021 APS and SPR Award Winners
Pediatr Res. 2022 Jan 10. doi: 10.1038/s41390-021-01864-1. Online ahead of print.NO ABSTRACTPMID:35013564 | DOI:10.1038/s41390-021-01864-1 (Source: Pediatric Research)
Source: Pediatric Research - January 11, 2022 Category: Pediatrics Source Type: research

ADHD symptoms and diagnosis in adult preterms: systematic review, IPD meta-analysis, and register-linkage study
This study examined differences in ADHD symptoms and diagnosis between preterm and term-born adults (≥18 years), and tested if ADHD is related to gestational age, birth weight, multiple births, or neonatal complications in preterm borns.METHODS: (1) A systematic review compared ADHD symptom self-reports and diagnosis between preterm and term-born adults published in PubMed, Web of Science, and PROQUEST until April 2021; (2) a one-stage Individual Participant Data(IPD) meta-analysis (n = 1385 preterm, n = 1633 term; born 1978-1995) examined differences in self-reported ADHD symptoms[age 18-36 years]; and (3) a population...
Source: Pediatric Research - January 8, 2022 Category: Pediatrics Authors: Rachel Robinson Polina Girchenko Anna Pulakka Kati Heinonen Anna L ähdepuro Marius Lahti-Pulkkinen Petteri Hovi Marjaana Tikanm äki Peter Bartmann Aulikki Lano Lex W Doyle Peter J Anderson Jeanie L Y Cheong Brian A Darlow Lianne J Woodward L John Horwoo Source Type: research

Oxygen saturation and heart rate in healthy term and late preterm infants with delayed cord clamping
Pediatr Res. 2022 Jan 7. doi: 10.1038/s41390-021-01805-y. Online ahead of print.ABSTRACTBlood oxygen in the fetus is substantially lower than in the newborn infant. In the minutes after birth, arterial oxygen saturation rises from around 50-60% to 90-95%. Initial respiratory efforts generate negative trans-thoracic pressures that drive liquid from the airways into the lung interstitium facilitating lung aeration, blood oxygenation, and pulmonary artery vasodilatation. Consequently, intra- (foramen ovale) and extra-cardiac (ductus arteriosus) shunting changes and the sequential circulation switches to a parallel pulmonary a...
Source: Pediatric Research - January 8, 2022 Category: Pediatrics Authors: Inmaculada Lara-Cant ón Shiraz Badurdeen Janneke Dekker Peter Davis Calum Roberts Arjan Te Pas M áximo Vento Source Type: research

Seasonality of birth month in patients diagnosed with Langerhans cell histiocytosis (LCH)
Pediatr Res. 2022 Jan 7. doi: 10.1038/s41390-021-01923-7. Online ahead of print.NO ABSTRACTPMID:34997224 | DOI:10.1038/s41390-021-01923-7 (Source: Pediatric Research)
Source: Pediatric Research - January 8, 2022 Category: Pediatrics Authors: Iliana R Close Nicolas Lee Jan-Inge Henter Source Type: research

Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials
CONCLUSIONS: This systematic review constitutes one of the initial phases in the protocol for developing a COS in neonatal sepsis. The paucity of standardised outcome reporting in neonatal sepsis hinders comparison and synthesis of data. The final phase will involve a Delphi Survey to generate a COS in neonatal sepsis by consensus recommendation.IMPACT: This systematic review identified a wide variation of outcomes reported among published RCTs on the management of neonatal sepsis. The paucity of standardised outcome reporting hinders comparison and synthesis of data and future meta-analyses with conclusive recommendations...
Source: Pediatric Research - January 8, 2022 Category: Pediatrics Authors: C ían J Henry Gergana Semova Ellen Barnes Isabel Cotter Tara Devers Aisyah Rafaee Andreea Slavescu Niamh O Cathain Danielle McCollum Edna Roche David Mockler John Allen Judith Meehan Claus Klingenberg Jos M Latour Agnes van den Hoogen Tobias Strunk Eric Source Type: research

ADHD symptoms and diagnosis in adult preterms: systematic review, IPD meta-analysis, and register-linkage study
This study examined differences in ADHD symptoms and diagnosis between preterm and term-born adults (≥18 years), and tested if ADHD is related to gestational age, birth weight, multiple births, or neonatal complications in preterm borns.METHODS: (1) A systematic review compared ADHD symptom self-reports and diagnosis between preterm and term-born adults published in PubMed, Web of Science, and PROQUEST until April 2021; (2) a one-stage Individual Participant Data(IPD) meta-analysis (n = 1385 preterm, n = 1633 term; born 1978-1995) examined differences in self-reported ADHD symptoms[age 18-36 years]; and (3) a population...
Source: Pediatric Research - January 8, 2022 Category: Pediatrics Authors: Rachel Robinson Polina Girchenko Anna Pulakka Kati Heinonen Anna L ähdepuro Marius Lahti-Pulkkinen Petteri Hovi Marjaana Tikanm äki Peter Bartmann Aulikki Lano Lex W Doyle Peter J Anderson Jeanie L Y Cheong Brian A Darlow Lianne J Woodward L John Horwoo Source Type: research

Oxygen saturation and heart rate in healthy term and late preterm infants with delayed cord clamping
Pediatr Res. 2022 Jan 7. doi: 10.1038/s41390-021-01805-y. Online ahead of print.ABSTRACTBlood oxygen in the fetus is substantially lower than in the newborn infant. In the minutes after birth, arterial oxygen saturation rises from around 50-60% to 90-95%. Initial respiratory efforts generate negative trans-thoracic pressures that drive liquid from the airways into the lung interstitium facilitating lung aeration, blood oxygenation, and pulmonary artery vasodilatation. Consequently, intra- (foramen ovale) and extra-cardiac (ductus arteriosus) shunting changes and the sequential circulation switches to a parallel pulmonary a...
Source: Pediatric Research - January 8, 2022 Category: Pediatrics Authors: Inmaculada Lara-Cant ón Shiraz Badurdeen Janneke Dekker Peter Davis Calum Roberts Arjan Te Pas M áximo Vento Source Type: research

Seasonality of birth month in patients diagnosed with Langerhans cell histiocytosis (LCH)
Pediatr Res. 2022 Jan 7. doi: 10.1038/s41390-021-01923-7. Online ahead of print.NO ABSTRACTPMID:34997224 | DOI:10.1038/s41390-021-01923-7 (Source: Pediatric Research)
Source: Pediatric Research - January 8, 2022 Category: Pediatrics Authors: Iliana R Close Nicolas Lee Jan-Inge Henter Source Type: research

Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials
CONCLUSIONS: This systematic review constitutes one of the initial phases in the protocol for developing a COS in neonatal sepsis. The paucity of standardised outcome reporting in neonatal sepsis hinders comparison and synthesis of data. The final phase will involve a Delphi Survey to generate a COS in neonatal sepsis by consensus recommendation.IMPACT: This systematic review identified a wide variation of outcomes reported among published RCTs on the management of neonatal sepsis. The paucity of standardised outcome reporting hinders comparison and synthesis of data and future meta-analyses with conclusive recommendations...
Source: Pediatric Research - January 8, 2022 Category: Pediatrics Authors: C ían J Henry Gergana Semova Ellen Barnes Isabel Cotter Tara Devers Aisyah Rafaee Andreea Slavescu Niamh O Cathain Danielle McCollum Edna Roche David Mockler John Allen Judith Meehan Claus Klingenberg Jos M Latour Agnes van den Hoogen Tobias Strunk Eric Source Type: research

ADHD symptoms and diagnosis in adult preterms: systematic review, IPD meta-analysis, and register-linkage study
This study examined differences in ADHD symptoms and diagnosis between preterm and term-born adults (≥18 years), and tested if ADHD is related to gestational age, birth weight, multiple births, or neonatal complications in preterm borns.METHODS: (1) A systematic review compared ADHD symptom self-reports and diagnosis between preterm and term-born adults published in PubMed, Web of Science, and PROQUEST until April 2021; (2) a one-stage Individual Participant Data(IPD) meta-analysis (n = 1385 preterm, n = 1633 term; born 1978-1995) examined differences in self-reported ADHD symptoms[age 18-36 years]; and (3) a population...
Source: Pediatric Research - January 8, 2022 Category: Pediatrics Authors: Rachel Robinson Polina Girchenko Anna Pulakka Kati Heinonen Anna L ähdepuro Marius Lahti-Pulkkinen Petteri Hovi Marjaana Tikanm äki Peter Bartmann Aulikki Lano Lex W Doyle Peter J Anderson Jeanie L Y Cheong Brian A Darlow Lianne J Woodward L John Horwoo Source Type: research

Oxygen saturation and heart rate in healthy term and late preterm infants with delayed cord clamping
Pediatr Res. 2022 Jan 7. doi: 10.1038/s41390-021-01805-y. Online ahead of print.ABSTRACTBlood oxygen in the fetus is substantially lower than in the newborn infant. In the minutes after birth, arterial oxygen saturation rises from around 50-60% to 90-95%. Initial respiratory efforts generate negative trans-thoracic pressures that drive liquid from the airways into the lung interstitium facilitating lung aeration, blood oxygenation, and pulmonary artery vasodilatation. Consequently, intra- (foramen ovale) and extra-cardiac (ductus arteriosus) shunting changes and the sequential circulation switches to a parallel pulmonary a...
Source: Pediatric Research - January 8, 2022 Category: Pediatrics Authors: Inmaculada Lara-Cant ón Shiraz Badurdeen Janneke Dekker Peter Davis Calum Roberts Arjan Te Pas M áximo Vento Source Type: research

Seasonality of birth month in patients diagnosed with Langerhans cell histiocytosis (LCH)
Pediatr Res. 2022 Jan 7. doi: 10.1038/s41390-021-01923-7. Online ahead of print.NO ABSTRACTPMID:34997224 | DOI:10.1038/s41390-021-01923-7 (Source: Pediatric Research)
Source: Pediatric Research - January 8, 2022 Category: Pediatrics Authors: Iliana R Close Nicolas Lee Jan-Inge Henter Source Type: research

Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials
CONCLUSIONS: This systematic review constitutes one of the initial phases in the protocol for developing a COS in neonatal sepsis. The paucity of standardised outcome reporting in neonatal sepsis hinders comparison and synthesis of data. The final phase will involve a Delphi Survey to generate a COS in neonatal sepsis by consensus recommendation.IMPACT: This systematic review identified a wide variation of outcomes reported among published RCTs on the management of neonatal sepsis. The paucity of standardised outcome reporting hinders comparison and synthesis of data and future meta-analyses with conclusive recommendations...
Source: Pediatric Research - January 8, 2022 Category: Pediatrics Authors: C ían J Henry Gergana Semova Ellen Barnes Isabel Cotter Tara Devers Aisyah Rafaee Andreea Slavescu Niamh O Cathain Danielle McCollum Edna Roche David Mockler John Allen Judith Meehan Claus Klingenberg Jos M Latour Agnes van den Hoogen Tobias Strunk Eric Source Type: research