Predictors of outcome in children with disorders of mitochondrial metabolism in the pediatric intensive care unit
Pediatr Res. 2021 Feb 24:1-7. doi: 10.1038/s41390-021-01410-z. Online ahead of print.ABSTRACTBACKGROUND: The aim of this study was to identify factors predicting outcome in patients with mitochondrial disease admitted to pediatric intensive care units (PICU).METHODS: Retrospective study of 2434 patients (age
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Johannes K Ehinger Michael Karlsson Fredrik Sj övall M ärta Leffler Shana E McCormack Sherri E Kubis Anna Åkesson Marni J Falk Todd J Kilbaugh Source Type: research

Persistent microbial contamination of incubators despite disinfection
CONCLUSION: Pathogenic contaminants persist on incubators despite disinfection and represent a risk for subsequent infection in preterm neonates. Improvements are needed concerning both the disinfection process and incubator design.IMPACT: Procedures of disinfection that are usually recommended in NICUs do not allow for totally eradicating bacteria from incubators. Preterm neonates are housed in incubators colonised with potentially pathogenic bacteria. The control of nosocomial infections in NICUs requires further researches concerning mechanisms of bacterial persistence and ways to fight against environmental colonisatio...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Marie Chavignon Marion Reboux Jason Tasse Anne Tristan Olivier Claris Fr édéric Laurent Marine Butin Source Type: research

Neonatal resuscitation research: closing the gap
Pediatr Res. 2021 Feb 24. doi: 10.1038/s41390-021-01403-y. Online ahead of print.NO ABSTRACTPMID:33627819 | DOI:10.1038/s41390-021-01403-y (Source: Pediatric Research)
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Arjan Te Pas Charles Christopher Roehr Elizabeth E Foglia Stuart Hooper Source Type: research

Early clinical and MRI biomarkers of cognitive and motor outcomes in very preterm born infants
This study aimed to identify which MRI and clinical assessments, alone or in combination, from (i) early (32 weeks postmenstrual age, PMA), (ii) term equivalent age (TEA) and (iii) 3 months corrected age (CA) are associated with motor or cognitive outcomes at 2 years CA in infants born
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Joanne M George Paul B Colditz Mark D Chatfield Simona Fiori Kerstin Pannek Jurgen Fripp Andrea Guzzetta Stephen E Rose Robert S Ware Roslyn N Boyd Source Type: research

Wisconsin Upper Respiratory Symptom Survey for Kids: Validation of an Illness-specific Quality of Life Instrument
CONCLUSIONS: WURSS-K shows strong psychometric properties for validity and reliability as either a single global factor or a two-factor structure. This instrument will be useful in both therapeutic trials and observational studies among children with ARI in ambulatory settings.IMPACT: WURSS-K is a valid and reliable illness-specific quality of life instrument that evaluates the impacts of ARIs on children. WURSS-K is designed for children 4-10 years of age, for whom there is a lack of validated assessment tools. This now validated instrument will be useful for future observational studies and therapeutic trials among child...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Kathryn M Schmit Roger Brown Supriya Hayer Mary M Checovich James E Gern Ellen R Wald Bruce Barrett Source Type: research

Cause of preterm birth and late-onset sepsis in very preterm infants: the EPIPAGE-2 cohort study
CONCLUSION: Very preterm infants born after hypertensive disorders or born after FGR had an increased risk of LOS compared to those born after preterm labor.IMPACT: Late-onset sepsis risk differs according to the cause of preterm birth. Compared with those born after preterm labor, infants born very preterm because of hypertensive disorders of pregnancy and/or fetal growth restriction display an increased risk for late-onset sepsis. Antenatal factors, in particular the full spectrum of causes leading to preterm birth, should be taken into consideration to better prevent and manage neonatal infectious morbidity and inform t...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Mathilde Letouzey Laurence Foix-L'H élias H éloïse Torchin Ayoub Mitha Andrei S Morgan Jennifer Zeitlin Gilles Kayem Emeline Maisonneuve Pierre Delorme Babak Khoshnood Monique Kaminski Pierre-Yves Ancel Pascal Boileau Elsa Lorthe EPIPAGE-2 Working Grou Source Type: research

A neonatal neuroNICU collaborative approach to neuromonitoring of posthemorrhagic ventricular dilation in preterm infants
Pediatr Res. 2021 Feb 24. doi: 10.1038/s41390-021-01406-9. Online ahead of print.ABSTRACTMorbidity and mortality in prematurely born infants have significantly improved due to advancement in perinatal care, development of NeuroNICU collaborative multidisciplinary approaches, and evidence-based management protocols that have resulted from a better understanding of perinatal risk factors and neuroprotective treatments. In premature infants with intraventricular hemorrhage (IVH), the detrimental secondary effect of posthemorrhagic ventricular dilation (PHVD) on the neurodevelopmental outcome can be mitigated by surgical inter...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Brett A Whittemore Dale M Swift Jennifer M Thomas Lina F Chalak Source Type: research

SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges
Pediatr Res. 2021 Feb 24:1-5. doi: 10.1038/s41390-021-01402-z. Online ahead of print.ABSTRACTAs the nation implements SARS-CoV-2 vaccination in adults at an unprecedented scale, it is now essential to focus on the prospect of SARS-CoV-2 vaccinations in pediatric populations. To date, no children younger than 12 years have been enrolled in clinical trials. Key challenges and knowledge gaps that must be addressed include (1) rationale for vaccines in children, (2) possible effects of immune maturation during childhood, (3) ethical concerns, (4) unique needs of children with developmental disorders and chronic conditions, (5)...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Dan M Cooper Behnoush Afghani Carrie L Byington Coleen K Cunningham Sidney Golub Kim D Lu Shlomit Radom-Aizik Lainie Friedman Ross Jasjit Singh William E Smoyer Candice Taylor Lucas Jessica Tunney Frank Zaldivar Erlinda R Ulloa Source Type: research

Predictors of outcome in children with disorders of mitochondrial metabolism in the pediatric intensive care unit
Pediatr Res. 2021 Feb 24:1-7. doi: 10.1038/s41390-021-01410-z. Online ahead of print.ABSTRACTBACKGROUND: The aim of this study was to identify factors predicting outcome in patients with mitochondrial disease admitted to pediatric intensive care units (PICU).METHODS: Retrospective study of 2434 patients (age
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Johannes K Ehinger Michael Karlsson Fredrik Sj övall M ärta Leffler Shana E McCormack Sherri E Kubis Anna Åkesson Marni J Falk Todd J Kilbaugh Source Type: research

Persistent microbial contamination of incubators despite disinfection
CONCLUSION: Pathogenic contaminants persist on incubators despite disinfection and represent a risk for subsequent infection in preterm neonates. Improvements are needed concerning both the disinfection process and incubator design.IMPACT: Procedures of disinfection that are usually recommended in NICUs do not allow for totally eradicating bacteria from incubators. Preterm neonates are housed in incubators colonised with potentially pathogenic bacteria. The control of nosocomial infections in NICUs requires further researches concerning mechanisms of bacterial persistence and ways to fight against environmental colonisatio...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Marie Chavignon Marion Reboux Jason Tasse Anne Tristan Olivier Claris Fr édéric Laurent Marine Butin Source Type: research

Neonatal resuscitation research: closing the gap
Pediatr Res. 2021 Feb 24. doi: 10.1038/s41390-021-01403-y. Online ahead of print.NO ABSTRACTPMID:33627819 | DOI:10.1038/s41390-021-01403-y (Source: Pediatric Research)
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Arjan Te Pas Charles Christopher Roehr Elizabeth E Foglia Stuart Hooper Source Type: research

Early clinical and MRI biomarkers of cognitive and motor outcomes in very preterm born infants
This study aimed to identify which MRI and clinical assessments, alone or in combination, from (i) early (32 weeks postmenstrual age, PMA), (ii) term equivalent age (TEA) and (iii) 3 months corrected age (CA) are associated with motor or cognitive outcomes at 2 years CA in infants born
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Joanne M George Paul B Colditz Mark D Chatfield Simona Fiori Kerstin Pannek Jurgen Fripp Andrea Guzzetta Stephen E Rose Robert S Ware Roslyn N Boyd Source Type: research

Wisconsin Upper Respiratory Symptom Survey for Kids: Validation of an Illness-specific Quality of Life Instrument
CONCLUSIONS: WURSS-K shows strong psychometric properties for validity and reliability as either a single global factor or a two-factor structure. This instrument will be useful in both therapeutic trials and observational studies among children with ARI in ambulatory settings.IMPACT: WURSS-K is a valid and reliable illness-specific quality of life instrument that evaluates the impacts of ARIs on children. WURSS-K is designed for children 4-10 years of age, for whom there is a lack of validated assessment tools. This now validated instrument will be useful for future observational studies and therapeutic trials among child...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Kathryn M Schmit Roger Brown Supriya Hayer Mary M Checovich James E Gern Ellen R Wald Bruce Barrett Source Type: research

Cause of preterm birth and late-onset sepsis in very preterm infants: the EPIPAGE-2 cohort study
CONCLUSION: Very preterm infants born after hypertensive disorders or born after FGR had an increased risk of LOS compared to those born after preterm labor.IMPACT: Late-onset sepsis risk differs according to the cause of preterm birth. Compared with those born after preterm labor, infants born very preterm because of hypertensive disorders of pregnancy and/or fetal growth restriction display an increased risk for late-onset sepsis. Antenatal factors, in particular the full spectrum of causes leading to preterm birth, should be taken into consideration to better prevent and manage neonatal infectious morbidity and inform t...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Mathilde Letouzey Laurence Foix-L'H élias H éloïse Torchin Ayoub Mitha Andrei S Morgan Jennifer Zeitlin Gilles Kayem Emeline Maisonneuve Pierre Delorme Babak Khoshnood Monique Kaminski Pierre-Yves Ancel Pascal Boileau Elsa Lorthe EPIPAGE-2 Working Grou Source Type: research

A neonatal neuroNICU collaborative approach to neuromonitoring of posthemorrhagic ventricular dilation in preterm infants
Pediatr Res. 2021 Feb 24. doi: 10.1038/s41390-021-01406-9. Online ahead of print.ABSTRACTMorbidity and mortality in prematurely born infants have significantly improved due to advancement in perinatal care, development of NeuroNICU collaborative multidisciplinary approaches, and evidence-based management protocols that have resulted from a better understanding of perinatal risk factors and neuroprotective treatments. In premature infants with intraventricular hemorrhage (IVH), the detrimental secondary effect of posthemorrhagic ventricular dilation (PHVD) on the neurodevelopmental outcome can be mitigated by surgical inter...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Brett A Whittemore Dale M Swift Jennifer M Thomas Lina F Chalak Source Type: research

SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges
Pediatr Res. 2021 Feb 24:1-5. doi: 10.1038/s41390-021-01402-z. Online ahead of print.ABSTRACTAs the nation implements SARS-CoV-2 vaccination in adults at an unprecedented scale, it is now essential to focus on the prospect of SARS-CoV-2 vaccinations in pediatric populations. To date, no children younger than 12 years have been enrolled in clinical trials. Key challenges and knowledge gaps that must be addressed include (1) rationale for vaccines in children, (2) possible effects of immune maturation during childhood, (3) ethical concerns, (4) unique needs of children with developmental disorders and chronic conditions, (5)...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Dan M Cooper Behnoush Afghani Carrie L Byington Coleen K Cunningham Sidney Golub Kim D Lu Shlomit Radom-Aizik Lainie Friedman Ross Jasjit Singh William E Smoyer Candice Taylor Lucas Jessica Tunney Frank Zaldivar Erlinda R Ulloa Source Type: research

Predictors of outcome in children with disorders of mitochondrial metabolism in the pediatric intensive care unit
Pediatr Res. 2021 Feb 24. doi: 10.1038/s41390-021-01410-z. Online ahead of print.ABSTRACTBACKGROUND: The aim of this study was to identify factors predicting outcome in patients with mitochondrial disease admitted to pediatric intensive care units (PICU).METHODS: Retrospective study of 2434 patients (age
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Johannes K Ehinger Michael Karlsson Fredrik Sj övall M ärta Leffler Shana E McCormack Sherri E Kubis Anna Åkesson Marni J Falk Todd J Kilbaugh Source Type: research

Persistent microbial contamination of incubators despite disinfection
CONCLUSION: Pathogenic contaminants persist on incubators despite disinfection and represent a risk for subsequent infection in preterm neonates. Improvements are needed concerning both the disinfection process and incubator design.IMPACT: Procedures of disinfection that are usually recommended in NICUs do not allow for totally eradicating bacteria from incubators. Preterm neonates are housed in incubators colonised with potentially pathogenic bacteria. The control of nosocomial infections in NICUs requires further researches concerning mechanisms of bacterial persistence and ways to fight against environmental colonisatio...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Marie Chavignon Marion Reboux Jason Tasse Anne Tristan Olivier Claris Fr édéric Laurent Marine Butin Source Type: research

Neonatal resuscitation research: closing the gap
Pediatr Res. 2021 Feb 24. doi: 10.1038/s41390-021-01403-y. Online ahead of print.NO ABSTRACTPMID:33627819 | DOI:10.1038/s41390-021-01403-y (Source: Pediatric Research)
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Arjan Te Pas Charles Christopher Roehr Elizabeth E Foglia Stuart Hooper Source Type: research

Early clinical and MRI biomarkers of cognitive and motor outcomes in very preterm born infants
This study aimed to identify which MRI and clinical assessments, alone or in combination, from (i) early (32 weeks postmenstrual age, PMA), (ii) term equivalent age (TEA) and (iii) 3 months corrected age (CA) are associated with motor or cognitive outcomes at 2 years CA in infants born
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Joanne M George Paul B Colditz Mark D Chatfield Simona Fiori Kerstin Pannek Jurgen Fripp Andrea Guzzetta Stephen E Rose Robert S Ware Roslyn N Boyd Source Type: research

Wisconsin Upper Respiratory Symptom Survey for Kids: Validation of an Illness-specific Quality of Life Instrument
CONCLUSIONS: WURSS-K shows strong psychometric properties for validity and reliability as either a single global factor or a two-factor structure. This instrument will be useful in both therapeutic trials and observational studies among children with ARI in ambulatory settings.IMPACT: WURSS-K is a valid and reliable illness-specific quality of life instrument that evaluates the impacts of ARIs on children. WURSS-K is designed for children 4-10 years of age, for whom there is a lack of validated assessment tools. This now validated instrument will be useful for future observational studies and therapeutic trials among child...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Kathryn M Schmit Roger Brown Supriya Hayer Mary M Checovich James E Gern Ellen R Wald Bruce Barrett Source Type: research

Cause of preterm birth and late-onset sepsis in very preterm infants: the EPIPAGE-2 cohort study
CONCLUSION: Very preterm infants born after hypertensive disorders or born after FGR had an increased risk of LOS compared to those born after preterm labor.IMPACT: Late-onset sepsis risk differs according to the cause of preterm birth. Compared with those born after preterm labor, infants born very preterm because of hypertensive disorders of pregnancy and/or fetal growth restriction display an increased risk for late-onset sepsis. Antenatal factors, in particular the full spectrum of causes leading to preterm birth, should be taken into consideration to better prevent and manage neonatal infectious morbidity and inform t...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Mathilde Letouzey Laurence Foix-L'H élias H éloïse Torchin Ayoub Mitha Andrei S Morgan Jennifer Zeitlin Gilles Kayem Emeline Maisonneuve Pierre Delorme Babak Khoshnood Monique Kaminski Pierre-Yves Ancel Pascal Boileau Elsa Lorthe EPIPAGE-2 Working Grou Source Type: research

A neonatal neuroNICU collaborative approach to neuromonitoring of posthemorrhagic ventricular dilation in preterm infants
Pediatr Res. 2021 Feb 24. doi: 10.1038/s41390-021-01406-9. Online ahead of print.ABSTRACTMorbidity and mortality in prematurely born infants have significantly improved due to advancement in perinatal care, development of NeuroNICU collaborative multidisciplinary approaches, and evidence-based management protocols that have resulted from a better understanding of perinatal risk factors and neuroprotective treatments. In premature infants with intraventricular hemorrhage (IVH), the detrimental secondary effect of posthemorrhagic ventricular dilation (PHVD) on the neurodevelopmental outcome can be mitigated by surgical inter...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Brett A Whittemore Dale M Swift Jennifer M Thomas Lina F Chalak Source Type: research

SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges
Pediatr Res. 2021 Feb 24. doi: 10.1038/s41390-021-01402-z. Online ahead of print.ABSTRACTAs the nation implements SARS-CoV-2 vaccination in adults at an unprecedented scale, it is now essential to focus on the prospect of SARS-CoV-2 vaccinations in pediatric populations. To date, no children younger than 12 years have been enrolled in clinical trials. Key challenges and knowledge gaps that must be addressed include (1) rationale for vaccines in children, (2) possible effects of immune maturation during childhood, (3) ethical concerns, (4) unique needs of children with developmental disorders and chronic conditions, (5) hea...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Dan M Cooper Behnoush Afghani Carrie L Byington Coleen K Cunningham Sidney Golub Kim D Lu Shlomit Radom-Aizik Lainie Friedman Ross Jasjit Singh William E Smoyer Candice Taylor Lucas Jessica Tunney Frank Zaldivar Erlinda R Ulloa Source Type: research

Predictors of outcome in children with disorders of mitochondrial metabolism in the pediatric intensive care unit
Pediatr Res. 2021 Feb 24. doi: 10.1038/s41390-021-01410-z. Online ahead of print.ABSTRACTBACKGROUND: The aim of this study was to identify factors predicting outcome in patients with mitochondrial disease admitted to pediatric intensive care units (PICU).METHODS: Retrospective study of 2434 patients (age
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Johannes K Ehinger Michael Karlsson Fredrik Sj övall M ärta Leffler Shana E McCormack Sherri E Kubis Anna Åkesson Marni J Falk Todd J Kilbaugh Source Type: research

Persistent microbial contamination of incubators despite disinfection
CONCLUSION: Pathogenic contaminants persist on incubators despite disinfection and represent a risk for subsequent infection in preterm neonates. Improvements are needed concerning both the disinfection process and incubator design.IMPACT: Procedures of disinfection that are usually recommended in NICUs do not allow for totally eradicating bacteria from incubators. Preterm neonates are housed in incubators colonised with potentially pathogenic bacteria. The control of nosocomial infections in NICUs requires further researches concerning mechanisms of bacterial persistence and ways to fight against environmental colonisatio...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Marie Chavignon Marion Reboux Jason Tasse Anne Tristan Olivier Claris Fr édéric Laurent Marine Butin Source Type: research

Neonatal resuscitation research: closing the gap
Pediatr Res. 2021 Feb 24. doi: 10.1038/s41390-021-01403-y. Online ahead of print.NO ABSTRACTPMID:33627819 | DOI:10.1038/s41390-021-01403-y (Source: Pediatric Research)
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Arjan Te Pas Charles Christopher Roehr Elizabeth E Foglia Stuart Hooper Source Type: research

Early clinical and MRI biomarkers of cognitive and motor outcomes in very preterm born infants
This study aimed to identify which MRI and clinical assessments, alone or in combination, from (i) early (32 weeks postmenstrual age, PMA), (ii) term equivalent age (TEA) and (iii) 3 months corrected age (CA) are associated with motor or cognitive outcomes at 2 years CA in infants born
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Joanne M George Paul B Colditz Mark D Chatfield Simona Fiori Kerstin Pannek Jurgen Fripp Andrea Guzzetta Stephen E Rose Robert S Ware Roslyn N Boyd Source Type: research

Wisconsin Upper Respiratory Symptom Survey for Kids: Validation of an Illness-specific Quality of Life Instrument
CONCLUSIONS: WURSS-K shows strong psychometric properties for validity and reliability as either a single global factor or a two-factor structure. This instrument will be useful in both therapeutic trials and observational studies among children with ARI in ambulatory settings.IMPACT: WURSS-K is a valid and reliable illness-specific quality of life instrument that evaluates the impacts of ARIs on children. WURSS-K is designed for children 4-10 years of age, for whom there is a lack of validated assessment tools. This now validated instrument will be useful for future observational studies and therapeutic trials among child...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Kathryn M Schmit Roger Brown Supriya Hayer Mary M Checovich James E Gern Ellen R Wald Bruce Barrett Source Type: research

Cause of preterm birth and late-onset sepsis in very preterm infants: the EPIPAGE-2 cohort study
CONCLUSION: Very preterm infants born after hypertensive disorders or born after FGR had an increased risk of LOS compared to those born after preterm labor.IMPACT: Late-onset sepsis risk differs according to the cause of preterm birth. Compared with those born after preterm labor, infants born very preterm because of hypertensive disorders of pregnancy and/or fetal growth restriction display an increased risk for late-onset sepsis. Antenatal factors, in particular the full spectrum of causes leading to preterm birth, should be taken into consideration to better prevent and manage neonatal infectious morbidity and inform t...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Mathilde Letouzey Laurence Foix-L'H élias H éloïse Torchin Ayoub Mitha Andrei S Morgan Jennifer Zeitlin Gilles Kayem Emeline Maisonneuve Pierre Delorme Babak Khoshnood Monique Kaminski Pierre-Yves Ancel Pascal Boileau Elsa Lorthe EPIPAGE-2 Working Grou Source Type: research

A neonatal neuroNICU collaborative approach to neuromonitoring of posthemorrhagic ventricular dilation in preterm infants
Pediatr Res. 2021 Feb 24. doi: 10.1038/s41390-021-01406-9. Online ahead of print.ABSTRACTMorbidity and mortality in prematurely born infants have significantly improved due to advancement in perinatal care, development of NeuroNICU collaborative multidisciplinary approaches, and evidence-based management protocols that have resulted from a better understanding of perinatal risk factors and neuroprotective treatments. In premature infants with intraventricular hemorrhage (IVH), the detrimental secondary effect of posthemorrhagic ventricular dilation (PHVD) on the neurodevelopmental outcome can be mitigated by surgical inter...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Brett A Whittemore Dale M Swift Jennifer M Thomas Lina F Chalak Source Type: research

SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges
Pediatr Res. 2021 Feb 24. doi: 10.1038/s41390-021-01402-z. Online ahead of print.ABSTRACTAs the nation implements SARS-CoV-2 vaccination in adults at an unprecedented scale, it is now essential to focus on the prospect of SARS-CoV-2 vaccinations in pediatric populations. To date, no children younger than 12 years have been enrolled in clinical trials. Key challenges and knowledge gaps that must be addressed include (1) rationale for vaccines in children, (2) possible effects of immune maturation during childhood, (3) ethical concerns, (4) unique needs of children with developmental disorders and chronic conditions, (5) hea...
Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Dan M Cooper Behnoush Afghani Carrie L Byington Coleen K Cunningham Sidney Golub Kim D Lu Shlomit Radom-Aizik Lainie Friedman Ross Jasjit Singh William E Smoyer Candice Taylor Lucas Jessica Tunney Frank Zaldivar Erlinda R Ulloa Source Type: research

Increased mitochondrial oxygen consumption in adult survivors of preterm birth
CONCLUSIONS: In conclusion, adults born preterm have higher basal and non-ATP-linked mitochondrial respiration. Similar mitochondrial profiles have previously been documented in diabetics, and may support the increased risk for cardiometabolic disease in adults born preterm.IMPACT: Adults born preterm have higher maximal but also higher basal and non-ATP-linked mitochondrial respiration. Similar mitochondrial profiles have previously been documented in diabetics, and may support the increased risk for cardiometabolic disease in adults born preterm. Prior studies demonstrate a link between perinatal mitochondrial function a...
Source: Pediatric Research - February 23, 2021 Category: Pediatrics Authors: Santosh Kumari Gregory P Barton Kara N Goss Source Type: research

Increased mitochondrial oxygen consumption in adult survivors of preterm birth
CONCLUSIONS: In conclusion, adults born preterm have higher basal and non-ATP-linked mitochondrial respiration. Similar mitochondrial profiles have previously been documented in diabetics, and may support the increased risk for cardiometabolic disease in adults born preterm.IMPACT: Adults born preterm have higher maximal but also higher basal and non-ATP-linked mitochondrial respiration. Similar mitochondrial profiles have previously been documented in diabetics, and may support the increased risk for cardiometabolic disease in adults born preterm. Prior studies demonstrate a link between perinatal mitochondrial function a...
Source: Pediatric Research - February 23, 2021 Category: Pediatrics Authors: Santosh Kumari Gregory P Barton Kara N Goss Source Type: research

Early career investigator highlight biocommentary
Pediatr Res. 2021 Feb 18. doi: 10.1038/s41390-021-01404-x. Online ahead of print.NO ABSTRACTPMID:33603206 | DOI:10.1038/s41390-021-01404-x (Source: Pediatric Research)
Source: Pediatric Research - February 19, 2021 Category: Pediatrics Authors: Kazumichi Fujioka Source Type: research

A new era: improving use of sociodemographic constructs in the analysis of pediatric cohort study data
Pediatr Res. 2021 Feb 18. doi: 10.1038/s41390-021-01386-w. Online ahead of print.ABSTRACTGiven the diversity of sex, gender identity, race, ethnicity, and socioeconomic position (SEP) in children across the United States, it is incumbent upon pediatric and epidemiologic researchers to conduct their work in ways that promote inclusivity, understanding and reduction in inequities. Current child health research often utilizes an approach of "convenience" in how data related to these constructs are collected, categorized, and included in models; the field needs to be more systematic and thoughtful in its approach to ...
Source: Pediatric Research - February 19, 2021 Category: Pediatrics Authors: Aruna Chandran Emily Knapp Tiange Liu Lorraine T Dean Source Type: research

Autism risk in neonatal intensive care unit patients associated with novel heart rate patterns
CONCLUSION: High HRskw in NICU males, perhaps representing autonomic imbalance, was associated with increased ASD risk. Further study is needed to determine whether HR analysis identifies highest-risk infants who might benefit from earlier screening and therapies.IMPACT: In a large retrospective single-center cohort of NICU patients, we found that high positive skewness of heart rate toward more accelerations was significantly associated with increased risk of eventual autism spectrum disorder diagnosis in male infants but not in females. Existing literature describes differences in heart rate characteristics in children, ...
Source: Pediatric Research - February 19, 2021 Category: Pediatrics Authors: Kaitlin R Blackard Katy N Krahn Robert T Andris Douglas E Lake Karen D Fairchild Source Type: research

Socioeconomic circumstances and lung function growth from early adolescence to early adulthood
CONCLUSIONS: Individuals from most disadvantaged SEC presented lower lung function at early adolescence compared to high-SEC counterparts; nevertheless, a catch-up growth was observed.IMPACT: Lower socioeconomic circumstances were previously associated with reduced lung function and a higher risk of respiratory diseases in adults. Fewer studies analysed the effects of early-life socioeconomic circumstances in lung function growth during adolescence. Disadvantaged socioeconomic circumstances were associated with lower lung function in early adolescence. However, social differences diminished over adolescence, suggesting a c...
Source: Pediatric Research - February 19, 2021 Category: Pediatrics Authors: V ânia Rocha Milton Severo Elisabete Ramos Helena Falc ão Silvia Stringhini S ílvia Fraga Source Type: research

Testicular torsion: its effect on autoimmunisation, pituitary-testis axis and correlation with primary gonadal dysfunction in boys
CONCLUSIONS: Results did not confirm the autoimmune process in boys with torsion of the testis. The pituitary-testis axis seems to have sufficient compensation capabilities. However, study results suggest that primary gonadal dysfunction may predispose to torsion.IMPACT: Significant differences exist between the literature data and own results on the formation of antibodies and hormonal changes due to testicular torsion in boys. It is a novel, prospective study on antibodies against sperms and Leydig cells in the serum and on hormonal processes occurring as a result of the testicular torsion from the prenatal period to the...
Source: Pediatric Research - February 19, 2021 Category: Pediatrics Authors: Pawe ł Osemlak Konrad Miszczuk Grzegorz J ędrzejewski Pawe ł Nachulewicz Iwona Be ń-Skowronek Agnieszka Brzozowska Source Type: research

Physiological dead space and alveolar ventilation in ventilated infants
Pediatr Res. 2021 Feb 18:1-5. doi: 10.1038/s41390-021-01388-8. Online ahead of print.ABSTRACTBACKGROUND: Dead space is the volume not taking part in gas exchange and, if increased, could affect alveolar ventilation if there is too low a delivered volume. We determined if there were differences in dead space and alveolar ventilation in ventilated infants with pulmonary disease or no respiratory morbidity.METHODS: A prospective study of mechanically ventilated infants was undertaken. Expiratory tidal volume and carbon dioxide levels were measured. Volumetric capnograms were constructed to calculate the dead space using the m...
Source: Pediatric Research - February 19, 2021 Category: Pediatrics Authors: Emma Williams Theodore Dassios Paul Dixon Anne Greenough Source Type: research

Essentials of data management: an overview
Pediatr Res. 2021 Feb 18. doi: 10.1038/s41390-021-01389-7. Online ahead of print.NO ABSTRACTPMID:33603212 | DOI:10.1038/s41390-021-01389-7 (Source: Pediatric Research)
Source: Pediatric Research - February 19, 2021 Category: Pediatrics Authors: Miren B Dhudasia Robert W Grundmeier Sagori Mukhopadhyay Source Type: research

A year without touch: a reflection on physician-patient interaction during COVID-19
Pediatr Res. 2021 Feb 18:1-2. doi: 10.1038/s41390-021-01390-0. Online ahead of print.NO ABSTRACTPMID:33603213 | PMC:PMC7891479 | DOI:10.1038/s41390-021-01390-0 (Source: Pediatric Research)
Source: Pediatric Research - February 19, 2021 Category: Pediatrics Authors: Teresa Vente Source Type: research

Ensuring continued progress for development of COVID-19 therapeutics in children
Pediatr Res. 2021 Feb 18:1-3. doi: 10.1038/s41390-021-01384-y. Online ahead of print.NO ABSTRACTPMID:33603214 | PMC:PMC7891471 | DOI:10.1038/s41390-021-01384-y (Source: Pediatric Research)
Source: Pediatric Research - February 19, 2021 Category: Pediatrics Authors: Gary J Noel Roberta L DeBiasi Wallace Crandall Edward M Connor Source Type: research

Hippocampal epigenetic and insulin-like growth factor alterations in noninvasive versus invasive mechanical ventilation in preterm lambs
CONCLUSIONS: NRS leads to distinct IGF1 mRNA variant levels and epigenetic profile in the hippocampus compared to IMV.IMPACT: Our study shows that 3 or 21 days of NRS of preterm lambs leads to distinct IGF1 mRNA variant levels and epigenetic profile in the hippocampus compared to IMV. Preterm infant studies suggest that NRS leads to better neurodevelopmental outcomes later in life versus IMV. Also, duration of IMV is directly related to hippocampal damage; however, molecular players remain unknown. NRS, as a gentler mode of respiratory management of preterm neonates, may reduce damage to the immature hippocampus through an...
Source: Pediatric Research - February 19, 2021 Category: Pediatrics Authors: Xingrao Ke Bohan Xing Mar Janna Dahl Jeremy Alvord Robert A McKnight Robert H Lane Kurt H Albertine Source Type: research

Postoperative breakthrough pain in paediatric cardiac surgery not reduced by increased morphine concentrations
Pediatr Res. 2021 Feb 18. doi: 10.1038/s41390-021-01383-z. Online ahead of print.ABSTRACTBACKGROUND: Morphine is commonly used for postoperative analgesia in children. Here we studied the pharmacodynamics of morphine in children after cardiac surgery receiving protocolized morphine.METHODS: Data on morphine rescue requirements guided by validated pain scores in children (n = 35, 3-36 months) after cardiac surgery receiving morphine as loading dose (100 μg kg-1) with continuous infusion (40 μg kg-1 h-1) from a previous study on morphine pharmacokinetics were analysed using repeated time-to-event (RTTE) modelling.RESUL...
Source: Pediatric Research - February 19, 2021 Category: Pediatrics Authors: Sjoerd de Hoogd Sebastiaan C Goulooze Abraham J Valkenburg Elke H J Krekels Monique van Dijk Dick Tibboel Catherijne A J Knibbe Source Type: research

Early career investigator highlight biocommentary.
PMID: 33603206 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - February 18, 2021 Category: Pediatrics Authors: Fujioka K Tags: Pediatr Res Source Type: research

A new era: improving use of sociodemographic constructs in the analysis of pediatric cohort study data.
Abstract Given the diversity of sex, gender identity, race, ethnicity, and socioeconomic position (SEP) in children across the United States, it is incumbent upon pediatric and epidemiologic researchers to conduct their work in ways that promote inclusivity, understanding and reduction in inequities. Current child health research often utilizes an approach of "convenience" in how data related to these constructs are collected, categorized, and included in models; the field needs to be more systematic and thoughtful in its approach to understand how sociodemographics affect child health. We offer suggesti...
Source: Pediatric Research - February 18, 2021 Category: Pediatrics Authors: Chandran A, Knapp E, Liu T, Dean LT Tags: Pediatr Res Source Type: research

Autism risk in neonatal intensive care unit patients associated with novel heart rate patterns.
CONCLUSION: High HRskw in NICU males, perhaps representing autonomic imbalance, was associated with increased ASD risk. Further study is needed to determine whether HR analysis identifies highest-risk infants who might benefit from earlier screening and therapies. IMPACT: In a large retrospective single-center cohort of NICU patients, we found that high positive skewness of heart rate toward more accelerations was significantly associated with increased risk of eventual autism spectrum disorder diagnosis in male infants but not in females. Existing literature describes differences in heart rate characteristics in chil...
Source: Pediatric Research - February 18, 2021 Category: Pediatrics Authors: Blackard KR, Krahn KN, Andris RT, Lake DE, Fairchild KD Tags: Pediatr Res Source Type: research

Socioeconomic circumstances and lung function growth from early adolescence to early adulthood.
CONCLUSIONS: Individuals from most disadvantaged SEC presented lower lung function at early adolescence compared to high-SEC counterparts; nevertheless, a catch-up growth was observed. IMPACT: Lower socioeconomic circumstances were previously associated with reduced lung function and a higher risk of respiratory diseases in adults. Fewer studies analysed the effects of early-life socioeconomic circumstances in lung function growth during adolescence. Disadvantaged socioeconomic circumstances were associated with lower lung function in early adolescence. However, social differences diminished over adolescence, suggesti...
Source: Pediatric Research - February 18, 2021 Category: Pediatrics Authors: Rocha V, Severo M, Ramos E, Falcão H, Stringhini S, Fraga S Tags: Pediatr Res Source Type: research

Testicular torsion: its effect on autoimmunisation, pituitary-testis axis and correlation with primary gonadal dysfunction in boys.
CONCLUSIONS: Results did not confirm the autoimmune process in boys with torsion of the testis. The pituitary-testis axis seems to have sufficient compensation capabilities. However, study results suggest that primary gonadal dysfunction may predispose to torsion. IMPACT: Significant differences exist between the literature data and own results on the formation of antibodies and hormonal changes due to testicular torsion in boys. It is a novel, prospective study on antibodies against sperms and Leydig cells in the serum and on hormonal processes occurring as a result of the testicular torsion from the prenatal period ...
Source: Pediatric Research - February 18, 2021 Category: Pediatrics Authors: Osemlak P, Miszczuk K, Jędrzejewski G, Nachulewicz P, Beń-Skowronek I, Brzozowska A Tags: Pediatr Res Source Type: research