Effects of postnatal corticosteroids on lung development in newborn animals. A systematic review
CONCLUSION: In newborn rodents, postnatal systemic corticosteroids have a persistent negative effect on body weight and lung development. There was huge heterogeneity in experimental models, mediocre study quality, unclear risk of bias, and very small subgroups for meta-analysis which limited firm conclusions.IMPACT: Postnatal corticosteroids reduce the risk of bronchopulmonary dysplasia but the effect depends on timing, dosing, and type of corticosteroids while the underlying mechanism of this variable effect is unknown. This is the first systematic review and meta-analysis of preclinical newborn animal studies reviewing ...
Source: Pediatric Research - March 17, 2024 Category: Pediatrics Authors: Irene M Lok Kimberley E Wever Roos J S Vliegenthart Wes Onland Anton H van Kaam Minke van Tuyl Source Type: research

Aerobic physical capacity and health-related quality of life in children with sickle cell disease
CONCLUSION: Aerobic capacity is poor in children with sickle cell disease. VO2max decrease is associated with the level of anemia, the existence of a homozygote HbS/S mutation, lung function, and health-related quality of life. These results represent a signal in favor of early initiation of cardiac rehabilitation in patients with sickle cell disease.CLINICAL TRIALS: NCT05995743.IMPACT: Aerobic fitness is a predictor of cardiovascular health which correlates with health-related quality of life in the general population. Aerobic capacity (VO2max) is poor in children with sickle cell disease, despite the absence of any patte...
Source: Pediatric Research - March 16, 2024 Category: Pediatrics Authors: Corentin Laurent-Lacroix Marie Vincenti Stefan Matecki Perrine Mah é Lionel Moulis Gregoire De La Villeon Sophie Guillaumont Anne Requirand Johan Moreau Muriel Lalande Marie-Christine Picot Pascal Amedro Arthur Gavotto Source Type: research

Educating caregivers about fever - what and why?
Pediatr Res. 2024 Mar 14. doi: 10.1038/s41390-024-03134-2. Online ahead of print.NO ABSTRACTPMID:38486081 | DOI:10.1038/s41390-024-03134-2 (Source: Pediatric Research)
Source: Pediatric Research - March 15, 2024 Category: Pediatrics Authors: Damian Roland Source Type: research

Educating caregivers about fever - what and why?
Pediatr Res. 2024 Mar 14. doi: 10.1038/s41390-024-03134-2. Online ahead of print.NO ABSTRACTPMID:38486081 | DOI:10.1038/s41390-024-03134-2 (Source: Pediatric Research)
Source: Pediatric Research - March 15, 2024 Category: Pediatrics Authors: Damian Roland Source Type: research

Educating caregivers about fever - what and why?
Pediatr Res. 2024 Mar 14. doi: 10.1038/s41390-024-03134-2. Online ahead of print.NO ABSTRACTPMID:38486081 | DOI:10.1038/s41390-024-03134-2 (Source: Pediatric Research)
Source: Pediatric Research - March 15, 2024 Category: Pediatrics Authors: Damian Roland Source Type: research

Epigenetic associations in HPA axis genes related to bronchopulmonary dysplasia and antenatal steroids
CONCLUSIONS: These findings suggest that BPD severity and antenatal steroids are associated with DNAm at some HPA genes in very preterm infants and the effects appear to be sex-, tissue-, and age-specific.IMPACT: This study addresses bronchopulmonary dysplasia (BPD), an important health outcome among preterm neonates, and interrogates a commonly studied pathway, the hypothalamic-pituitary-adrenal (HPA) axis. The combination of BPD, the HPA axis, and epigenetic markers has not been previously reported. In this study, we found that BPD itself was not associated with epigenetic responses in the HPA axis in infants born very p...
Source: Pediatric Research - March 14, 2024 Category: Pediatrics Authors: Kenyaita M Hodge Vasyl Zhabotynsky Amber A Burt Brian S Carter Rebecca C Fry Jennifer Helderman Julie A Hofheimer Elisabeth C McGowan Charles R Neal Steven L Pastyrnak Lynne M Smith Sheri A DellaGrotta Lynne M Dansereau Barry M Lester Carmen J Marsit T Mi Source Type: research

New insights and potential biomarkers for intraventricular hemorrhage in extremely premature infant, case-control study
CONCLUSION: This study identifies biomolecules that may be linked to subsequent germinal matrix-intraventricular hemorrhage, suggesting heightened vascular disruption risk as an independent factor. These results need further validation but could serve as early germinal matrix-intraventricular hemorrhage risk biomarkers for future evaluations.IMPACT: Decrease in certain phosphatidylcholines and increase in four proteins in cord blood at birth may be linked to subsequent germinal matrix-intraventricular hemorrhage in premature newborns. The four proteins are BOC cell adhesion-associated protein, placental growth factor, leuk...
Source: Pediatric Research - March 12, 2024 Category: Pediatrics Authors: Franklin Ducatez Abdellah Tebani Lenaig Abily-Donval Sarah Snanoudj Carine Pilon Thomas Plichet Charlotte Le Chatelier Soumeya Bekri St éphane Marret Source Type: research

New insights and potential biomarkers for intraventricular hemorrhage in extremely premature infant, case-control study
CONCLUSION: This study identifies biomolecules that may be linked to subsequent germinal matrix-intraventricular hemorrhage, suggesting heightened vascular disruption risk as an independent factor. These results need further validation but could serve as early germinal matrix-intraventricular hemorrhage risk biomarkers for future evaluations.IMPACT: Decrease in certain phosphatidylcholines and increase in four proteins in cord blood at birth may be linked to subsequent germinal matrix-intraventricular hemorrhage in premature newborns. The four proteins are BOC cell adhesion-associated protein, placental growth factor, leuk...
Source: Pediatric Research - March 12, 2024 Category: Pediatrics Authors: Franklin Ducatez Abdellah Tebani Lenaig Abily-Donval Sarah Snanoudj Carine Pilon Thomas Plichet Charlotte Le Chatelier Soumeya Bekri St éphane Marret Source Type: research

New insights and potential biomarkers for intraventricular hemorrhage in extremely premature infant, case-control study
CONCLUSION: This study identifies biomolecules that may be linked to subsequent germinal matrix-intraventricular hemorrhage, suggesting heightened vascular disruption risk as an independent factor. These results need further validation but could serve as early germinal matrix-intraventricular hemorrhage risk biomarkers for future evaluations.IMPACT: Decrease in certain phosphatidylcholines and increase in four proteins in cord blood at birth may be linked to subsequent germinal matrix-intraventricular hemorrhage in premature newborns. The four proteins are BOC cell adhesion-associated protein, placental growth factor, leuk...
Source: Pediatric Research - March 12, 2024 Category: Pediatrics Authors: Franklin Ducatez Abdellah Tebani Lenaig Abily-Donval Sarah Snanoudj Carine Pilon Thomas Plichet Charlotte Le Chatelier Soumeya Bekri St éphane Marret Source Type: research

Correction: Prenatal metal concentrations and physical abnormalities in the Japan environment and children's study
Pediatr Res. 2024 Mar 8. doi: 10.1038/s41390-024-03099-2. Online ahead of print.NO ABSTRACTPMID:38459222 | DOI:10.1038/s41390-024-03099-2 (Source: Pediatric Research)
Source: Pediatric Research - March 8, 2024 Category: Pediatrics Authors: Yuichi Nakamura Sumitaka Kobayashi Kazutoshi Cho Sachiko Itoh Chihiro Miyashita Takeshi Yamaguchi Hiroyoshi Iwata Naomi Tamura Yasuaki Saijo Yoshiya Ito Yoshitaka Seto Ryota Honjo Akiko Ando Yuta Furuse Atsushi Manabe Reiko Kishi Japan Environment and Chi Source Type: research

Correction: Prenatal metal concentrations and physical abnormalities in the Japan environment and children's study
Pediatr Res. 2024 Mar 8. doi: 10.1038/s41390-024-03099-2. Online ahead of print.NO ABSTRACTPMID:38459222 | DOI:10.1038/s41390-024-03099-2 (Source: Pediatric Research)
Source: Pediatric Research - March 8, 2024 Category: Pediatrics Authors: Yuichi Nakamura Sumitaka Kobayashi Kazutoshi Cho Sachiko Itoh Chihiro Miyashita Takeshi Yamaguchi Hiroyoshi Iwata Naomi Tamura Yasuaki Saijo Yoshiya Ito Yoshitaka Seto Ryota Honjo Akiko Ando Yuta Furuse Atsushi Manabe Reiko Kishi Japan Environment and Chi Source Type: research

Correction: Prenatal metal concentrations and physical abnormalities in the Japan environment and children's study
Pediatr Res. 2024 Mar 8. doi: 10.1038/s41390-024-03099-2. Online ahead of print.NO ABSTRACTPMID:38459222 | DOI:10.1038/s41390-024-03099-2 (Source: Pediatric Research)
Source: Pediatric Research - March 8, 2024 Category: Pediatrics Authors: Yuichi Nakamura Sumitaka Kobayashi Kazutoshi Cho Sachiko Itoh Chihiro Miyashita Takeshi Yamaguchi Hiroyoshi Iwata Naomi Tamura Yasuaki Saijo Yoshiya Ito Yoshitaka Seto Ryota Honjo Akiko Ando Yuta Furuse Atsushi Manabe Reiko Kishi Japan Environment and Chi Source Type: research

Association between patent ductus arteriosus flow and home oxygen therapy in extremely preterm infants
CONCLUSION: We present the central blood flow values and their postnatal development in infants <26 weeks of gestation. This study demonstrates the association between PDA flow and the future need for home oxygen therapy.IMPACT: This study enriches our knowledge of the long-term development of central blood flow parameters and derived patent ductus arteriosus (PDA) flow in extremely preterm infants (<26 weeks). While pulmonary resistance decreased, PDA flow continued to increase from day 4 to the end of the second week of life. Similarly, left ventricular output increased as a marker of preload. The superior vena cav...
Source: Pediatric Research - March 7, 2024 Category: Pediatrics Authors: Jana Termerova Ales A Kubena Karel Liska Viktor Tomek Richard Plavka Source Type: research

Association between patent ductus arteriosus flow and home oxygen therapy in extremely preterm infants
CONCLUSION: We present the central blood flow values and their postnatal development in infants <26 weeks of gestation. This study demonstrates the association between PDA flow and the future need for home oxygen therapy.IMPACT: This study enriches our knowledge of the long-term development of central blood flow parameters and derived patent ductus arteriosus (PDA) flow in extremely preterm infants (<26 weeks). While pulmonary resistance decreased, PDA flow continued to increase from day 4 to the end of the second week of life. Similarly, left ventricular output increased as a marker of preload. The superior vena cav...
Source: Pediatric Research - March 7, 2024 Category: Pediatrics Authors: Jana Termerova Ales A Kubena Karel Liska Viktor Tomek Richard Plavka Source Type: research

Publication Recommendations to Report Laboratory Data of Neonates - a Modified Delphi Approach
CONCLUSION: Our recommendations provide guidance on standardization of neonatal laboratory data in publications. This will enhance the comparison, replication, and application of study results in research initiatives and clinical practice. Furthermore, these recommendations also serve as foundational work to develop reference ranges for neonatal laboratory values by standardizing the quality of information needed for such efforts.IMPACT: Standardized reporting of neonatal laboratory data in scientific publications will enhance the comparison, replication, and application of study results in research initiatives and clinica...
Source: Pediatric Research - March 6, 2024 Category: Pediatrics Authors: Zo ë Vander Elst Heidrun Hildebrand Mary A Short Nick Henscheid Robert Ward Ronald Ariagno Thomas Diacovo Tim Lang Karel Allegaert Anne Smits International Neonatal Consortium Source Type: research