Intraventricular hemorrhage and white matter injury: is persistent cerebral desaturation a missing link?
PMID: 33247218 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 27, 2020 Category: Pediatrics Authors: Chawla S, Chock VY, Lakshminrusimha S Tags: Pediatr Res Source Type: research

Gender inequalities on editorial boards of indexed pediatrics journals.
CONCLUSIONS: Only one-fifth of ECs and one-third of EBMs are females. Women's participation is higher in journals related to nursing, physical and occupational therapy, and nutrition. The United States has the highest number of EBMs, followed by the European Union. IMPACT: Only one-fifth of Editors-in-chief in pediatrics journals are female. Only one-third of Editorial Board Members in pediatrics journals are female. Women's participation is higher in editorials committees in pediatrics journals related to nursing, physical and occupational therapy, and nutrition. Medical and pediatric associations and societies must ...
Source: Pediatric Research - November 25, 2020 Category: Pediatrics Authors: Alonso-Arroyo A, González de Dios J, Aleixandre-Agulló J, Aleixandre-Benavent R Tags: Pediatr Res Source Type: research

Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children's Study.
CONCLUSIONS: Maternal alcohol consumption during pregnancy, even in early pregnancy, displayed no significant adverse impact on congenital malformations of interest. IMPACT: This large-scale Japanese cohort study revealed that no teratogenic associations were found between maternal retrospective reports of periconceptional alcohol consumption and congenital malformations after adjustment for covariates. This is the first nationwide birth cohort study in Japan to assess the effect of maternal alcohol consumption during pregnancy on major congenital malformations. Our finding indicated that maternal low-to-moderate alco...
Source: Pediatric Research - November 23, 2020 Category: Pediatrics Authors: Kurita H, Motoki N, Inaba Y, Misawa Y, Ohira S, Kanai M, Tsukahara T, Nomiyama T, Japan Environment and Children’s Study (JECS) Group Tags: Pediatr Res Source Type: research

Children with Down syndrome and sleep disordered breathing have altered cardiovascular control.
Abstract BACKGROUND: Sleep disordered breathing (SDB) in typically developing (TD) children is associated with adverse cardiovascular effects. As children with Down syndrome (DS) are at increased risk for SDB, we aimed to compare the cardiovascular effects of SDB in children with DS to those of TD children with and without SDB. METHODS: Forty-four children with DS (3-19 years) were age and sex matched with 44 TD children without SDB (TD-) and with 44 TD children with matched severity of SDB (TD+). Power spectral density was calculated from ECG recordings, for low frequency (LF), high frequency (HF), total pow...
Source: Pediatric Research - November 23, 2020 Category: Pediatrics Authors: Horne RSC, Sakthiakumaran A, Bassam A, Thacker J, Walter LM, Davey MJ, Nixon GM Tags: Pediatr Res Source Type: research

Distinct whole-blood transcriptome profile of children with metabolic healthy overweight/obesity compared to metabolic unhealthy overweight/obesity.
CONCLUSIONS: The identified gene expression patterns related to metabolism, mitochondrial, and immune functions contribute to a better understanding of why a subset of the population remains metabolically healthy despite having overweight/obesity. IMPACT: A distinct pattern of whole-blood transcriptome profile (RNA-seq) was identified in children with metabolic healthy overweight/obesity (MHO) compared to metabolic unhealthy overweight/obesity (MUO) phenotype. The most relevant genes in understanding the molecular basis underlying the MHO/MUO phenotypes in children could be: RREB1, FAM83E, SLC44A1, NRG1, TMC5, CYP3A5,...
Source: Pediatric Research - November 23, 2020 Category: Pediatrics Authors: Plaza-Florido A, Altmäe S, Esteban FJ, Cadenas-Sanchez C, Aguilera CM, Einarsdottir E, Katayama S, Krjutškov K, Kere J, Zaldivar F, Radom-Aizik S, Ortega FB Tags: Pediatr Res Source Type: research

Honoring Professor Maria Delivoria-Papadopoulos.
PMID: 33230196 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 23, 2020 Category: Pediatrics Authors: Golombek SG, Anday E, Davis J, Escobedo M Tags: Pediatr Res Source Type: research

Equity culture in pediatrics.
PMID: 33230197 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 23, 2020 Category: Pediatrics Authors: Fuentes-Afflick E Tags: Pediatr Res Source Type: research

Personalized nutrition approach in pediatrics: a narrative review.
Abstract Dietary habits represent the main determinant of health. Although extensive research has been conducted to modify unhealthy dietary behaviors across the lifespan, obesity and obesity-associated comorbidities are increasingly observed worldwide. Individually tailored interventions are nowadays considered a promising frontier for nutritional research. In this narrative review, the technologies of importance in a pediatric clinical setting are discussed. The first determinant of the dietary balance is represented by energy intakes matching individual needs. Most emerging studies highlight the opportunity to ...
Source: Pediatric Research - November 23, 2020 Category: Pediatrics Authors: Milani GP, Silano M, Mazzocchi A, Bettocchi S, De Cosmi V, Agostoni C Tags: Pediatr Res Source Type: research

First aid for Medicaid: losses in children's health insurance.
PMID: 33219326 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 20, 2020 Category: Pediatrics Authors: Shah S, Kuo AA, Brumberg HL Tags: Pediatr Res Source Type: research

Effect of digestion on stability of palivizumab IgG1 in the infant gastrointestinal tract.
CONCLUSION: Antibodies generated for passive protection of the infant gastrointestinal tract from pathogens will need to be more resistant to digestion than the model antibody fed to infants in this study, or provided in higher doses to be most effective. IMPACT: Binding activity of palivizumab IgG1 decreased (26-99%) across each phase of in vivo infant digestion as measured by both anti-idiotype and RSV F protein-specific ELISAs. Palivizumab was likely degraded by proteases and changes in pH introduced in the gut. Antibodies generated for passive protection of the infant gastrointestinal tract from pathogens will nee...
Source: Pediatric Research - November 19, 2020 Category: Pediatrics Authors: Lueangsakulthai J, Kim BJ, Demers-Mathieu V, Sah BNP, Woo Y, Olyaei A, Aloia M, O'Connor A, Scottoline BP, Dallas DC Tags: Pediatr Res Source Type: research

Racial differences in opioid withdrawal syndrome among neonates with intrauterine opioid exposure.
CONCLUSIONS: Severe NOWS that required pharmacological intervention was significantly higher in White than in Black infants born to mothers who did not attend OMTP. Larger studies are needed to evaluate the association between social as well as genetic factors and the development of NOWS. IMPACT: There is a significant association between race and development of severe NOWS. PMID: 33214673 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 19, 2020 Category: Pediatrics Authors: Pourcyrous M, Elabiad MT, Rana D, Gaston KP, DeBaer L, Dhanireddy R Tags: Pediatr Res Source Type: research

Valuing and achieving diversity in academic medicine : The APS and SPR Virtual Chat Series.
PMID: 33214674 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 19, 2020 Category: Pediatrics Authors: Moxey-Mims M, Steinhorn R, Fuentes-Afflick E Tags: Pediatr Res Source Type: research

Familial central precocious puberty: two novel MKRN3 mutations.
CONCLUSIONS: We describe two novel MKRN3 mutations in three CPP patients. The first long-term data on a boy with CPP due to an MKRN3 mutation questions the role of GnRH analog treatment in augmenting adult height in males with this condition. IMPACT: We describe the genetic cause for central precocious puberty (CPP) in two families. This report adds two novel MKRN3 mutations to the existing literature. One of the mutations, p.(Ile313Met) affects the RING finger domain of MKRN3, which has been shown to be important for repressing the promoter activity of KISS1 and TAC3. We describe the first long-term observation of a ...
Source: Pediatric Research - November 19, 2020 Category: Pediatrics Authors: Varimo T, Iivonen AP, Känsäkoski J, Wehkalampi K, Hero M, Vaaralahti K, Miettinen PJ, Niedziela M, Raivio T Tags: Pediatr Res Source Type: research

Reply to comment: "Brain creatine alteration and executive function deficits in children born very preterm".
Reply to comment: "Brain creatine alteration and executive function deficits in children born very preterm". Pediatr Res. 2020 Nov 19;: Authors: Schnider B, Disselhoff V, Latal B, Wehrle F, Hagmann C, Tuura R PMID: 33214676 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 19, 2020 Category: Pediatrics Authors: Schnider B, Disselhoff V, Latal B, Wehrle F, Hagmann C, Tuura R Tags: Pediatr Res Source Type: research

Save the kidneys in COVID-19.
PMID: 33214677 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 19, 2020 Category: Pediatrics Authors: Knight PP, Deep A Tags: Pediatr Res Source Type: research

Identification of prognostic factors for pediatric myocarditis with a random forests algorithm-assisted approach.
CONCLUSION: Prognostic factor identification may not be straightforward in rare diseases such as pediatric myocarditis due to small cohort size in each treating facility. Findings from this report provide insights into the prognostic factors for pediatric myocarditis, and may allow clinicians to be better prepared when informing patients and their families regarding disease outcomes. IMPACT: The rate of hospitalization due to pediatric myocarditis was increasing but the mortality rate was declining over the past decade. End organ damage, including the brain and the kidney, was associated with mortality and prolonged h...
Source: Pediatric Research - November 18, 2020 Category: Pediatrics Authors: Chou FS, Ghimire LV Tags: Pediatr Res Source Type: research

Comment on: Serial blood cytokine and chemokine mRNA and microRNA over 48  h are insult specific in a piglet model of inflammation-sensitized hypoxia-ischaemia.
Comment on: Serial blood cytokine and chemokine mRNA and microRNA over 48 h are insult specific in a piglet model of inflammation-sensitized hypoxia-ischaemia. Pediatr Res. 2020 Nov 17;: Authors: Felderhoff-Müser U PMID: 33203964 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 17, 2020 Category: Pediatrics Authors: Felderhoff-Müser U Tags: Pediatr Res Source Type: research

Infant weight-for-length gain associated with autonomic nervous system reactivity.
CONCLUSIONS: These findings suggest an association between early life adiposity gain and the development of infant ANS regulation. IMPACT: Adiposity gain during early infancy was associated with autonomic nervous system regulation at 6 months. This study identifies early adiposity gain (greater than average infant weight-for-length gain) as a risk for ANS dysregulation. This research focuses on a critical developmental period of ANS plasticity. If confirmed, findings can be used to inform early intervention programs targeting obesity prevention and to promote self-regulation. PMID: 33203965 [PubMed - as supplied ...
Source: Pediatric Research - November 17, 2020 Category: Pediatrics Authors: Rudd KL, Alkon A, Abrams B, Bush NR Tags: Pediatr Res Source Type: research

Using a cartoon questionnaire to improve consent process in children: a randomized controlled survey.
Abstract OBJECTIVE: The aim of the study was to evaluate the effectiveness of an audio and animated cartoon questionnaire (AACQ) at improving consent process in child for biospecimen donation. METHODS: A multi-center randomized and controlled survey was performed at two pediatric hospitals in China from 2019 to 2020. Children aged from 7 to 18 years in the pediatric surgery wards were invited to investigate the participants' willingness and attitudes for donating biospecimens. A total of 264 children, including 119 in the AACQ group and 145 in the TQ group, and 67 parents of children were analyzed. A separate...
Source: Pediatric Research - November 17, 2020 Category: Pediatrics Authors: Qiu S, Xia Y, Tian F, Yang Y, Song J, Chen L, Mei H, Jiang F, Bao N, Liu S Tags: Pediatr Res Source Type: research

Cognitive and behavioral risk factors for low quality of life in survivors of childhood acute lymphoblastic leukemia.
Abstract BACKGROUND: With high survival rates for pediatric acute lymphoblastic leukemia (ALL), long-term quality of life is a prominent consideration in treatment. We concurrently evaluated cognition, behavior, and quality of life in child and adolescent ALL survivors and determined associations between them. METHODS: The sample included 83 controls (mean age: 12.5 years) and 71 ALL survivors (mean age: 11.9 years, mean age at diagnosis: 3.8 years). Participants completed measures of general intellectual abilities, math achievement, and fine motor skills. Parents and teachers completed a survey assessing chi...
Source: Pediatric Research - November 17, 2020 Category: Pediatrics Authors: van der Plas E, Spencer Noakes TL, Butcher DT, Weksberg R, Galin-Corini L, Wanstall EA, Te P, Hopf L, Guger S, Hitzler J, Schachar RJ, Ito S, Nieman BJ Tags: Pediatr Res Source Type: research

The prevalence of ankyloglossia in children aged < 1 year: a systematic review and meta-analysis.
The prevalence of ankyloglossia in children aged
Source: Pediatric Research - November 13, 2020 Category: Pediatrics Authors: Hill RR, Lee CS, Pados BF Tags: Pediatr Res Source Type: research

Gaining a deeper understanding of social determinants of preterm birth by integrating multi-omics data.
Abstract In the US, high rates of preterm birth (PTB) and profound Black-White disparities in PTB have persisted for decades. This review focuses on the role of social determinants of health (SDH), with an emphasis on maternal stress, in PTB disparity and biological embedding. It covers: (1) PTB disparity in US Black women and possible contributors; (2) the role of SDH, highlighting maternal stress, in the persistent racial disparity of PTB; (3) epigenetics at the interface between genes and environment; (4) the role of the genome in modifying maternal stress-PTB associations; (5) recent advances in multi-omics st...
Source: Pediatric Research - November 13, 2020 Category: Pediatrics Authors: Hong X, Bartell TR, Wang X Tags: Pediatr Res Source Type: research

Racial and socioeconomic disparities in breast milk feedings in US neonatal intensive care units.
Abstract Very low birth weight (VLBW;
Source: Pediatric Research - November 13, 2020 Category: Pediatrics Authors: Patel AL, Johnson TJ, Meier PP Tags: Pediatr Res Source Type: research

Post-hemorrhagic ventricular dilatation: inter-observer reliability of ventricular size measurements in extremely preterm infants.
CONCLUSIONS: AHW and VI are highly reproducible in experienced hands compared to FTHR, with AHW from the second week onwards being the strongest predictor for receiving surgical intervention for severe PHVD. AHW may aid in early PHVD diagnosis and decision-making on intervention. IMPACT: While ventricular size indices from serial cUS are superior to clinical signs of increased intracranial pressure to assess PHVD, questions remained on their inter-observer reproducibility and reliability to predict severity of PHVD. AHW and VI are highly reproducible when performed by experienced clinicians. AHW from the second week o...
Source: Pediatric Research - November 12, 2020 Category: Pediatrics Authors: Leijser LM, Scott JN, Roychoudhury S, Zein H, Murthy P, Thomas SP, Mohammad K, Calgary Neonatal Neuro-Critical Care Program Tags: Pediatr Res Source Type: research

Do preterm girls need different nutrition to preterm boys? Sex-specific nutrition for the preterm infant.
Abstract Boys born preterm are recognised to be at higher risk of adverse outcomes than girls born preterm. Despite advances in neonatal intensive care and overall improvements in neonatal morbidity and mortality, boys born preterm continue to show worse short- and long-term outcomes than girls. Preterm birth presents a nutritional crisis during a critical developmental period, with postnatal undernutrition and growth-faltering common complications of neonatal intensive care. Furthermore, this preterm period corresponds to that of rapid in utero brain growth and development, and the developmental window relating t...
Source: Pediatric Research - November 12, 2020 Category: Pediatrics Authors: Tottman AC, Oliver CJ, Alsweiler JM, Cormack BE Tags: Pediatr Res Source Type: research

Placental programming, perinatal inflammation, and neurodevelopment impairment among those born extremely preterm.
Abstract Individuals born extremely preterm are at significant risk for impaired neurodevelopment. After discharge from the neonatal intensive care, associations between the child's well-being and factors in the home and social environment become increasingly apparent. Mothers' prenatal health and socioeconomic status are associated with neurodevelopmental outcomes, and emotional and behavioral problems. Research on early life risk factors and on mechanisms underlying inter-individual differences in neurodevelopment later in life can inform the design of personalized approaches to prevention. Here, we review early...
Source: Pediatric Research - November 12, 2020 Category: Pediatrics Authors: Bangma JT, Hartwell H, Santos HP, O'Shea TM, Fry RC Tags: Pediatr Res Source Type: research

Prolonged hospital length of stay in pediatric trauma: a model for targeted interventions.
CONCLUSIONS: The high performance of the machine learning model coupled with statistical inference from the mixed effects model provide an opportunity for targeted interventions to improve quality of care of trauma patients likely to require long length of stay. IMPACT: Targeted interventions on high-risk patients would improve the quality of care of pediatric trauma patients and reduce the length of stay. This comprehensive study includes data from multiple hospitals analyzed with advanced statistical and machine learning models. The statistical and machine learning models provide opportunities for targeted intervent...
Source: Pediatric Research - November 12, 2020 Category: Pediatrics Authors: Gibbs D, Ehwerhemuepha L, Moreno T, Guner Y, Yu P, Schomberg J, Wallace E, Feaster W Tags: Pediatr Res Source Type: research

Global Pediatric Research Investigator: Modupe Coker.
PMID: 33184500 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 12, 2020 Category: Pediatrics Authors: Coker M Tags: Pediatr Res Source Type: research

A review of the role of extracellular vesicles in neonatal physiology and pathology.
This article summarises the current knowledge of the effect of EVs in neonates. It describes the potential compensatory role of EVs in neonatal haemostasis. It also describes the role of EVs as mediators of pathology and as potential biomarkers of perinatal and neonatal disease. PMID: 33184501 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 12, 2020 Category: Pediatrics Authors: Murphy CA, O'Reilly DP, Neary E, El-Khuffash A, NíAinle F, McCallion N, Maguire PB Tags: Pediatr Res Source Type: research

Families' perspectives on monitoring infants' health and development after discharge from NICUs.
PMID: 33184502 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 12, 2020 Category: Pediatrics Authors: O'Shea TM Tags: Pediatr Res Source Type: research

Hidden etiology of cerebral palsy: genetic and clinical heterogeneity and efficient diagnosis by next-generation sequencing.
We report 11/20 patients (55%) with different pathogenic or potentially pathogenic variants detected by exome sequencing analysis: five patients with mutations in genes related to hereditary spastic paraplegia, two with mutations in genes related to Aicardi-Goutières syndrome, three with mutations in genes related to developmental/epileptic encephalopathies, and one with a mutation in the PGK1 gene. The accurate and precise patients' selection, the use of a high-throughput genetic platform, the selection of adequate target genes, and the application of rigorous criteria for the clinical interpretation are the most i...
Source: Pediatric Research - November 11, 2020 Category: Pediatrics Authors: Rosello M, Caro-Llopis A, Orellana C, Oltra S, Alemany-Albert M, Marco-Hernandez AV, Monfort S, Pedrola L, Martinez F, Tomás M Tags: Pediatr Res Source Type: research

The urgent need for research coordination to advance knowledge on COVID-19 in children.
PMID: 33177674 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 11, 2020 Category: Pediatrics Authors: Bourgeois FT, Avillach P, Turner MA Tags: Pediatr Res Source Type: research

Antenatal corticosteroids: a reappraisal of the drug formulation and dose.
Abstract We review the history of antenatal corticosteroid therapy (ACS) and present recent experimental data to demonstrate that this, one of the pillars of perinatal care, has been inadequately evaluated to minimize fetal exposure to these powerful medications. There have been concerns since 1972 that fetal exposures to ACS convey risk. However, this developmental modulator, with its multiple widespread biologic effects, has not been evaluated for drug choice, dose, or duration of treatment, despite over 30 randomized trials. The treatment used in the United States is two intramuscular doses of a mixture of 6&th...
Source: Pediatric Research - November 11, 2020 Category: Pediatrics Authors: Jobe AH, Kemp M, Schmidt A, Takahashi T, Newnham J, Milad M Tags: Pediatr Res Source Type: research

Bringing research directly to families in the era of COVID-19.
PMID: 33177676 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 11, 2020 Category: Pediatrics Authors: Balevic SJ, Singler L, Randell R, Chung RJ, Lemmon ME, Hornik CP Tags: Pediatr Res Source Type: research

Prenatal opioid exposure is associated with smaller brain volumes in multiple regions.
CONCLUSIONS: Infants with prenatal opioid exposure had smaller brain volumes in multiple regions compared to controls, with two regions larger in the opioid-exposed group. Further research should focus on the relative contributions of maternal opioids and other exposures. IMPACT: Prenatal opioid exposure is associated with developmental and behavioral consequences, but the direct effects of opioids on the developing human brain are poorly understood. Prior small studies using MRI have shown smaller regional brain volumes in opioid-exposed infants and children. After controlling for covariates, infants with prenatal op...
Source: Pediatric Research - November 11, 2020 Category: Pediatrics Authors: Merhar SL, Kline JE, Braimah A, Kline-Fath BB, Tkach JA, Altaye M, He L, Parikh NA Tags: Pediatr Res Source Type: research

Budesonide with surfactant decreases systemic responses in mechanically ventilated preterm lambs exposed to fetal intra-amniotic lipopolysaccharide.
CONCLUSIONS: In preterm lambs exposed to IA LPS, the addition of budesonide to surfactant improved physiology and markers of lung and systemic inflammation. IMPACT: The addition of budesonide to surfactant decreases the lung and systemic responses to injurious mechanical ventilation preterm lambs exposed to fetal LPS. Budesonide was present in the plasma by 15 min and the majority of the budesonide is no longer in the lung at 4 h of ventilation. IA LPS and mechanical ventilation caused structural changes in the brain that were not altered by short-term exposure to budesonide. The budesonide dose of 0.25&...
Source: Pediatric Research - November 11, 2020 Category: Pediatrics Authors: Hillman NH, Kemp MW, Fee E, Rittenschober-Böhm J, Royse E, Abugisisa L, Salomone F, Musk GC, Jobe AH Tags: Pediatr Res Source Type: research

Transcutaneous bilirubin measurements: useful, but also reproducible?
PMID: 33173170 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Dani C, Hulzebos CV, Tiribelli C Tags: Pediatr Res Source Type: research

Use of color in journal figures.
PMID: 33173171 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Klebanoff MA Tags: Pediatr Res Source Type: research

Fifty-three years of follow-up of an infant with neonatal encephalopathy treated with therapeutic hypothermia.
PMID: 33173172 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Carlson R, Battin MR, Bennet L, Gunn AJ Tags: Pediatr Res Source Type: research

Prone sleeping affects cardiovascular control in preterm infants in NICU.
CONCLUSIONS: Prone sleeping dampens cardiovascular control in early postnatal life in preterm infants, having potential implications for BP regulation in infants undergoing intensive care. PMID: 33173173 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Shepherd KL, Wong FY, Odoi A, Yeomans E, Horne RSC, Yiallourou SR Tags: Pediatr Res Source Type: research

Prediction of ABO hemolytic disease of the newborn using pre- and perinatal quantification of maternal anti-A/anti-B IgG titer.
l MH Abstract BACKGROUND: Hemolysis in fetus/newborns is often caused by maternal antibodies. There are currently no established screening procedures for maternal ABO antibodies harmful to fetus/newborn. We investigated the clinical significance, and predictive value of maternal anti-A/B titer for hyperbilirubinemia in ABO-incompatible newborns. METHODS: We conducted a case-control study of blood group O mothers and their ABO-compatible (O) vs. -incompatible (A/B) newborns receiving phototherapy, and of ABO-incompatible newborns receiving phototherapy vs. no phototherapy. Newborn data and treatment modalities...
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Krog GR, Donneborg ML, Hansen BM, Lorenzen H, Clausen FB, Jensen KV, Kjærbye-Thygesen A, Albertsen P, Ebbesen F, Bergholt T, Smed MK, Dziegiel MH Tags: Pediatr Res Source Type: research

Defining pediatric asthma: phenotypes to endotypes and beyond.
Abstract Asthma is the most common chronic pediatric lung disease that has traditionally been defined as a syndrome of airway inflammation characterized by clinical symptoms of cough and wheeze. Highlighting the complex and heterogeneous nature of asthma, this review summarizes recent advances in asthma classification that are based on pathobiology, and thereby directly addresses limitations of existent definitions of asthma. By reviewing and contrasting clinical and mechanistic features of adult and childhood asthma, the review summarizes key biomarkers that distinguish childhood asthma subtypes. While atopy and ...
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Conrad LA, Cabana MD, Rastogi D Tags: Pediatr Res Source Type: research

GPRI: Mir Ibrahim Sajid.
PMID: 33173176 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Sajid MI Tags: Pediatr Res Source Type: research

Congenital chloride diarrhea clinical features and management: a systematic review.
CONCLUSIONS: This analysis of a large population suggests the necessity of better strategies for the management of CLD. A close follow-up and a multidisciplinary approach is mandatory to manage this condition characterized by heterogeneous and multisystemic complications. IMPACT: In this systematic review, we describe data regarding anamnestic features, clinical features, management, and follow-up of CLD patients obtained from the largest population of patients ever described to date. The results of our investigation could provide useful insights for the diagnostic approach and the management of this condition. ...
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Di Meglio L, Castaldo G, Mosca C, Paonessa A, Gelzo M, Esposito MV, Berni Canani R Tags: Pediatr Res Source Type: research

Risk factors for recurrent respiratory tract infection in preschool-aged children.
Abstract BACKGROUND: We aimed to identify potential risk factors for recurrent respiratory tract infection among Chinese preschool-aged children, and further to construct a nomogram prediction model. METHODS: This is a cross-sectional survey conducted in Beijing. Utilizing a stratified cluster random sampling strategy, a total of 7222 children from 20 kindergartens were enrolled. Data are analyzed by STATA software and R language. RESULTS: Five independent factors were identified to be significantly associated with recurrent respiratory tract infection risk overall and by pathogenic sites. The significan...
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Zhou B, Niu W, Liu F, Yuan Y, Wang K, Zhang J, Wang Y, Zhang Z Tags: Pediatr Res Source Type: research

Nitrite in breast milk: roles in neonatal pathophysiology.
Abstract Dietary nitrate has beneficial effects on health maintenance and prevention of lifestyle-related diseases in adulthood by serving as an alternative source of nitric oxide (NO) through the enterosalivary nitrate-nitrite-NO pathway, particularly when endogenous NO generation is lacking due to vascular endothelial dysfunction. However, this pathway is not developed in the early postnatal period due to a lack of oral commensal nitrate-reducing bacteria and less saliva production than in adults. To compensate for the decrease in nitrite during this period, colostrum contains the highest amount of nitrite compa...
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Kobayashi J Tags: Pediatr Res Source Type: research

Where to make a difference: research and the social determinants in pediatrics and child health in the COVID-19 era.
Abstract IMPACT: Raises the importance of Social Determinants of Health in pediatrics. Considers the impact of Social Determinants of Health on COVID-19. Offers opportunities for research in the future. PMID: 33173180 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Lachman P Tags: Pediatr Res Source Type: research

T cell cytokines in the diagnostic of early-onset sepsis.
This study aimed to determine serum concentrations of 13 cytokines in umbilical cord blood and evaluate their diagnostic value for EOS. METHODS: A prospective single-center study that included analysis of umbilical cord blood of term and preterm neonates who were born from March 2017 to November 2017. Using ELISA analysis, 13 cytokines were simultaneously quantified and correlated with the development of EOS. RESULTS: Four hundred and seventy-four neonates were included, of which seven met the criteria for culture-positive EOS. Interleukin (IL)-6 (p 
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Froeschle GM, Bedke T, Boettcher M, Huber S, Singer D, Ebenebe CU Tags: Pediatr Res Source Type: research

The pubertal growth spurt is diminished in children with severe obesity.
CONCLUSIONS: Obesity in childhood impairs the pubertal growth spurt in a severity-related fashion. IMPACT: The higher the BMI in childhood, the lower the pubertal height gain in children with moderate-to-extreme obesity. For boys with obesity, the higher the BMI, the earlier the onset of pubertal growth. The results contribute to the research field of how weight status in childhood is related to pubertal timing and pubertal growth. The results have implications for understanding how childhood obesity is related to further growth. PMID: 33173182 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Holmgren A, Martos-Moreno GÁ, Niklasson A, Martínez-Villanueva J, Argente J, Albertsson-Wikland K Tags: Pediatr Res Source Type: research

Sequence variants in the renin-angiotensin system genes are associated with isolated multicystic dysplastic kidney in children.
CONCLUSION: We report novel associations of sequence variants in REN, AGT, ACE, or AGTR1 genes in children with isolated MCDK in the United States. Our findings suggest a recessive disease model and support the hypothesis of multiple renin-angiotensin system gene involvement in MCDK. IMPACT: Discovery of novel gene variants in renin-angiotensin genes in children with MCDK. Novel possibly damaging gene variants discovered. Multiple renin-angiotensin system gene variants are involved in MCDK. PMID: 33173183 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Song R, Yosypiv IV Tags: Pediatr Res Source Type: research