"J Thorac Dis"[ta]; +115 new citations
115 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "J Thorac Dis"[ta] These pubmed results were generated on 2018/12/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - December 7, 2018 Category: Respiratory Medicine Tags: Report Source Type: research

Update on surgical and non-surgical management of COPD.
Authors: Scarci M PMID: 30450236 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 20, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Complications related to endoscopic lung volume reduction for emphysema with endobronchial valves: results of a multicenter study.
Authors: Fiorelli A, D'Andrilli A, Bezzi M, Ibrahim M, Anile M, Diso D, Cusumano G, Terminella A, Luzzi V, Innocenti M, Novali M, Carelli E, Freda C, Natale G, Peritore V, Poggi C, Failla G, Basile M, Mazzucca E, Conforti S, Serra N, Torre M, Venuta F, Rendina EA, Santini M, Andreetti C Abstract Background: Despite bronchoscopic lung volume reduction (BLVR) with valves is a minimally invasive treatment for emphysema, it can associate with some complications. We aimed at evaluating the rate and type of complications related to valve treatment and their impact on clinical outcomes. Methods: It is a retrospective ...
Source: Journal of Thoracic Disease - November 20, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

History of lung volume reduction procedures.
In conclusion, LVR procedures may be considered in carefully selected patients with symptomatic emphysema and severe lung hyperinflation, and might be personalized according to the anatomical characteristics of emphysematous area. PMID: 30450238 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 20, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The role of a multidisciplinary severe chronic obstructive pulmonary disease hyperinflation service in patient selection for lung volume reduction.
Authors: Chew J, Mahadeva R Abstract Chronic obstructive pulmonary disease (COPD) is a complex disease and the management is focused on improving breathlessness, quality of life and healthcare utilisation. Our understanding of COPD phenotypes has improved in recent years and there is an increased drive towards delivering phenotype-based therapies. Lung volume reduction can offer the prospect of life changing benefit in breathlessness and quality of life in a select group of patients with severe emphysema already receiving maximum medical treatment. In spite of the available evidence, very few procedures are being p...
Source: Journal of Thoracic Disease - November 20, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Surgical and endoscopic treatment for COPD: patients selection, techniques and results.
Authors: Minervini F, Kestenholz PB, Paolini V, Pesci A, Libretti L, Bertolaccini L, Scarci M Abstract Chronic obstructive pulmonary disease (COPD) is a very heterogeneous disease characterised by an obstructive lung pattern that constitutes worldwide a major cause of high morbidity and mortality. In the last decades, lung volume reduction surgery (LVRS) has demonstrated to be a potential good alternative to transplantation in patients affected by COPD. The trend toward minimally invasive techniques resulted not only in surgical procedures better tolerated by the patients but also in several endoscopic treatments m...
Source: Journal of Thoracic Disease - November 20, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Bronchoscopic management of prolonged air leak.
Authors: Bertolaccini L, Bonfanti B, Kawamukai K, Forti Parri SN, Lacava N, Solli P Abstract Broncho-pleural fistula (BPF) is an atypical communication between the tracheobronchial tree and the alveolar/pleural space, with prolonged air leak (PAL). BPF is frequent and related to significant morbidity, prolonged length of hospital stay, and mortality. Nevertheless, in about 10%, more than 5 days of an air leak is considered a PAL, accounted for significant morbidity. Endobronchial valve is a novel device for the PAL management with minimal morbidity if related to surgical repairs. While it is suggested that surgical...
Source: Journal of Thoracic Disease - November 20, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Transplant options for end stage chronic obstructive pulmonary disease in the context of multidisciplinary treatments.
Authors: Santambrogio L, Tarsia P, Mendogni P, Tosi D Abstract Lung transplantation (LTx) in advanced stage chronic obstructive pulmonary disease (COPD) patients is associated with significant improvement in lung function and exercise capacity. However, demonstration that the procedure also provides a survival benefit has been more elusive compared to other respiratory conditions. Identification of patients with increased risk of mortality is crucial: a low forced expiratory volume in 1 second (FEV1) is perhaps the most common reason for referral to a lung transplant center, but in itself is insufficient to identif...
Source: Journal of Thoracic Disease - November 20, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Lung volume reduction followed by lung transplantation-considerations on selection criteria and outcome.
Authors: Slama A, Taube C, Kamler M, Aigner C Abstract Lung transplantation (LuTX) and lung volume reduction (LVR), either surgical (LVRS: lung volume reduction surgery) or endoscopic (ELVR: endoscopic lung volume reduction), are established therapies in the treatment of end-stage chronic obstructive pulmonary disease (COPD) patients. Careful patient selection is crucial for each intervention. If these techniques are sequentially applied there is a paucity of available data and individual center experiences vary depending on details in selection criteria and operative technique. This review aims to summarize the pu...
Source: Journal of Thoracic Disease - November 20, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Osimertinib therapy as first-line treatment before acquiring T790M mutation: from AURA1 trial.
Authors: Ito K, Hataji O PMID: 30430025 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 16, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Extended sleeve lobectomy: its place in surgical therapy for centrally located non-small cell lung cancer and a review of technical aspects.
Authors: Waseda R, Iwasaki A PMID: 30430026 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 16, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Neoadjuvant PD-1 blockade in non-small cell lung cancer: what else do we need to do?
Authors: Guo W, Yang S, Zhang W, Li H, Lu B PMID: 30430027 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 16, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Peri-procedural myocardial infarction is all the same?
Authors: Jinnouchi H, Sakakura K, Fujita H PMID: 30430028 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 16, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Sortilin as a new membrane inhibitor of EGFR trafficking for overcoming resistance to EGFR inhibitors in non-small cell lung cancer.
Authors: Li Q, Ma W, Li T PMID: 30430029 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 16, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Editorial on "current state of empyema management".
Editorial on "current state of empyema management". J Thorac Dis. 2018 Sep;10(Suppl 26):S3271-S3273 Authors: Saha SP, Rodgers-Fischl P PMID: 30430030 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 16, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Combination immuno-oncology therapy with pembrolizumab, an anti-PD-1 monoclonal antibody targeting immune evasion, and standard chemotherapy for patients with the squamous and non-squamous subtypes of non-small cell lung cancer.
Authors: Katoh M PMID: 30416762 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Non-small cell lung cancer: land of conquest for immunotherapy.
Authors: Munari E, Bogina G PMID: 30416763 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Moving away (finally) from doublet therapy in lung cancer: immunotherapy and KEYNOTE-189.
Authors: Sheela S, Kim ES, Mileham KF PMID: 30416764 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Broader indications for checkpoint inhibitors in NSCLC.
Authors: Mellemgaard A PMID: 30416765 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Is the new distribution of early esophageal adenocarcinoma stages improving the prognostic prediction of the 8th edition of the TNM staging system for esophageal cancer?
Conclusions: We used the SEER database to compare the staging of early esophageal adenocarcinomas between the 8th and 7th editions of the AJCC/UICC TNM staging system. Based on our data, the 8th edition is not superior to the 7th edition. PMID: 30416766 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Application of the "continuous suture dividing and equal suture tightening" method in video-assisted thoracoscopic surgery sleeve lobectomy.
Conclusions: The continuous suture dividing and equal suture tightening method is convenient, feasible, and safe for bronchial anastomosis in VATS sleeve lobectomy. It can effectively avoid the entanglement of the suture threads, thereby enabling the widespread adoption of VATS sleeve lobectomy. PMID: 30416767 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Deep sternal infections after in situ bilateral internal thoracic artery grafting for left ventricular myocardial revascularization: predictors and influence on 20-year outcomes.
Conclusions: With an accurate patient selection (i.e., exclusion of obese diabetic females) and strict DM control BITA represents a first choice for most of CABG patients, even at high risk for DSWI. The occurrence of DSWI does not influence long-term survival and late outcomes. Our findings should be confirmed by further larger research. PMID: 30416768 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Transcatheter perimembranous ventricular septal defect closure under transthoracic echocardiographic guidance without fluoroscopy.
Conclusions: Transcatheter pm-VSD closure can be successfully performed under TTE guidance alone with outcomes similar to those achieved with fluoroscopic guidance in selected patients with weight more than 10 kg and VSD smaller than 8 mm. However, long-term follow-up in a large number of patients would be necessary. PMID: 30416769 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Neutrophil/lymphocyte ratio is helpful for predicting weaning failure: a prospective, observational cohort study.
Authors: Luo Z, Zheng Y, Yang L, Liu S, Zhu J, Zhao N, Pang B, Cao Z, Ma Y Abstract Background: To assess the usefulness of the neutrophil/lymphocyte ratio (NLR), a marker of inflammation and/or stress, for predicting weaning failure in patients receiving invasive mechanical ventilation (IMV), compared to levels of leukocytes and C-reactive protein (CRP). Methods: This observational prospective cohort study was conducted from July 2013 to December 2016 in an intensive care unit in China, enrolling 269 consecutive patients receiving IMV. Patients underwent a spontaneous breathing trial (SBT) if they were ready t...
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Elevated interleukin-6 and bronchiectasis as risk factors for acute exacerbation in patients with tuberculosis-destroyed lung with airflow limitation.
Authors: Oh JY, Lee YS, Min KH, Hur GY, Lee SY, Kang KH, Rhee CK, Park SJ, Shim JJ Abstract Background: Patients with tuberculosis-destroyed lungs (TDLs), with airflow limitation, have clinical characteristics similar to those of patients with chronic obstructive pulmonary disease (COPD). Acute exacerbation is an important factor in the management of TDL. Therefore, the aim of this study was to investigate the factors associated with acute exacerbations in patients with stable TDL with airflow limitation. Methods: We evaluated the clinical characteristics, such as lung function, image findings, and serum labora...
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Clinical predictors of pathologically response after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma: long term outcomes of a phase II study.
Conclusions: Our study indicated that good tumor grade were an independent significant factor for the GR to NCRT. Weight loss, drinking status and GR were independent factors in patients with radical esophagectomy after NCRT. GR may improve OS of ESCC patients receiving NCRT. PMID: 30416772 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Fibrinogen as a potential biomarker for clinical phenotype in patients with chronic obstructive pulmonary disease.
Conclusions: High fibrinogen level seems to reflect frequent exacerbation and severe symptomatic phenotypes in Korean patients with COPD. PMID: 30416773 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Thoracic ultrasound versus artificial pneumothorax in complications of medical thoracoscopy-a propensity score matching analysis.
Conclusions: TU is a locating approach method which does not increase the complication rate comparing with AP. And it could be a good choice in medical thoracoscopy. PMID: 30416774 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Effect of cyclosporine A on mortality after acute exacerbation of idiopathic pulmonary fibrosis.
Conclusions: Cyclosporine A did not reduce in-hospital mortality in patients with AE-IPF. Randomised controlled studies are required to confirm this apparent lack of effect of cyclosporine A in AE-IPF. PMID: 30416775 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Over-expression of calpastatin attenuates myocardial injury following myocardial infarction by inhibiting endoplasmic reticulum stress.
Conclusions: Over-expression of calpastatin ameliorates MI-induced myocardial injury in mice. These protective effects of calpastatin are partially achieved through suppression of the ER stress/CHOP pathway. PMID: 30416776 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Prognostic value of prognostic nutritional index in lung cancer: a meta-analysis.
Conclusions: PNI was an independent prognostic indicator for lung cancer, and can serve as a novel biomarker to help guide clinical practice and promote clinical outcomes of lung cancer patients. PMID: 30416777 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Spread through air spaces predicts a worse survival in patients with stage I adenocarcinomas > 2 cm after radical lobectomy.
Spread through air spaces predicts a worse survival in patients with stage I adenocarcinomas>2 cm after radical lobectomy. J Thorac Dis. 2018 Sep;10(9):5308-5317 Authors: Yang L, Yang Y, Ma P, Zheng B, Liu W, Zhang Z, Ding N, Liu L, Mao Y, Lv N Abstract Background: The aim of this study was to evaluate the significance of spread through air spaces (STAS) in early lung adenocarcinomas after radical lobectomy and lymphadenectomy. Methods: A total of 242 patients with lung adenocarcinomas less than 4 cm (8th pStage I) were selected from the lung cancer patients surgically treated from January, 2009...
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Pulmonary and mediastinal paragangliomas: rare endothoracic malignancies with challenging diagnosis and treatment.
Conclusions: Endothoracic paragangliomas, rare and often asymptomatic tumors, are of difficult diagnosis and should be considered malignant tumors, due to the potential aggressive behaviour of cases with high mitotic index and the frequent possibility of recurrence and metastases. Surgical resection is the treatment of choice and careful intraoperative manipulation is recommended, due to the high vascularity of these tumors, to prevent complications. After complete excision, long-term prognosis is generally good. However, even after surgical removal, a close, periodical and life-long follow-up is mandatory. PMID: 30416...
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

A subset of esophageal squamous cell carcinoma patient-derived xenografts respond to cetuximab, which is predicted by high EGFR expression and amplification.
This study aims at investigating the adaptive cetuximab subset in a cohort of esophageal squamous cell carcinoma (ESCC) patient-derived xenografts (PDXs). Methods: A large panel of ESCC PDXs has been established. The copy number, mRNA expression and immunohistochemistry (IHC) of key EGFR pathways have been examined along with cetuximab response. A preclinical trial on a randomly selected cohort of 16 ESCC PDXs was conducted, and the genomic annotations of these models were compared against the efficacy readout of the mouse trial. Results: The trial identified that 7 of 16 (43.8%) responded to cetuximab (ΔT/ΔC
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Suturing of the laser resection area is recommended over a depth of 2 cm in an experimental porcine lung model.
Authors: Kirschbaum A, Surowiec TM, Pehl A, Gockel A, Bartsch DK, Mirow N Abstract Background: Lung metastases can be removed by an Nd:YAG laser to save lung parenchyma. At these sites, a coagulated lung surface remains. Airtightness was investigated in relation to the depth of resection on an ex vivo porcine lung model. Methods: Freshly slaughtered porcine double lung preparations were connected to a ventilator via a tube. Non-anatomical laser resections were performed with an 800 µm laser fiber and the Nd:YAG laser LIMAX® 120 (power: 40 and 60 watts). The following resection depths (each n=12) from ...
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Serum decorin is a potential prognostic biomarker in patients with acute exacerbation of idiopathic pulmonary fibrosis.
Conclusions: Serum decorin levels are a potential prognostic biomarker in AE-IPF. PMID: 30416782 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Fluorescent image-based evaluation of gastric conduit perfusion in a preclinical ischemia model.
Conclusions: We successfully created an ischemic animal model of the gastric conduit. Using this animal model, we evaluated the sensitivity and applicability of the fluorescent imaging system for observation and identification of ischemic areas during an esophagectomy. PMID: 30416783 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Risk factors of cough in non-small cell lung cancer patients after video-assisted thoracoscopic surgery.
Conclusions: Female sex, duration of anesthesia over 164 minutes, lower paratracheal node resection and subcarinal node resection were independent risk factors related to cough in NSCLC patients after VATS. In addition, the LCQ-MC performed satisfactorily in describing the longitudinal changes in cough symptoms. PMID: 30416784 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Frozen elephant trunk with modified en bloc arch reconstruction and left subclavian transposition for chronic type A dissection.
Conclusions: Acceptable early and mid-term outcomes were achieved for patients with chronic type A dissection using en bloc technique with LSCA-LCCA transposition during TAR and FET procedure. This technique may be an alternative approach to chronic type A dissection in selected patients. PMID: 30416785 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Micropapillary or solid pattern predicts recurrence free survival benefit from adjuvant chemotherapy in patients with stage IB lung adenocarcinoma.
Authors: Ma M, She Y, Ren Y, Dai C, Zhang L, Xie H, Wu C, Yang M, Xie D, Chen C Abstract Background: Our study aimed to evaluate the prognostic significance and adjuvant chemotherapy (ACT) benefits of a micropapillary/solid (MS) pattern in patients with stage IB lung adenocarcinoma. Methods: Patients with pathologically-confirmed stage IB adenocarcinoma who underwent surgical resection between January 2009 and December 2011 were included. The tumors were reclassified into three categories: MS patterns absent (MS-); non-predominant MS patterns (MS+); predominant MS (MS++). The correlations of prognosis and ACT w...
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Practice of diagnosis and management of acute respiratory distress syndrome in mainland China: a cross-sectional study.
Authors: Liu L, Yang Y, Gao Z, Li M, Mu X, Ma X, Li G, Sun W, Wang X, Gu Q, Zheng R, Zhao H, Ao D, Yu W, Wang Y, Chen K, Yan J, Li J, Cai G, Wang Y, Wang H, Kang Y, S.sky AS, Liu S, Xie J, Qiu H Abstract Background: Although acute respiratory distress syndrome (ARDS) has been recognized for more than 50 years, limited information exists about the incidence and management of ARDS in mainland China. To evaluate the potential for improvement in management of patients with ARDS, this study was designed to describe the incidence and management of ARDS in mainland China. Methods: National prospective multicenter obse...
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Nationwide use of inhaled corticosteroids by South Korean asthma patients: an examination of the Health Insurance Review and Service database.
This study included 831,613 patients and 16,804 institutions in the analysis. The overall mean ICS prescription rate was 22.58%. Tertiary hospitals had the highest mean prescription rate (84.16%) whereas primary healthcare clinics had the lowest (20.71%). By specialty, internal medicine physicians prescribed ICS more frequently compared to other specialists. Of all, 47.17% of medical institutions prescribed ICS to 80% of asthma patients. Also, we found that female and patients with age>90 or
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Characteristics and survival difference of clinical tumor size 0 extensive-stage small cell lung cancer with different metastasis pattern.
Conclusions: The patients at cT0 stage was a different subgroup compared with the patients at cT1-4 stage for ES-SCLC patients with distant metastasis. PMID: 30416789 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Contemporary outcomes of surgical management of complex thoracic infections.
Conclusions: CTI's are a common indication for thoracic surgical management. This contemporary, national sampling demonstrates that approximately one third of identified cases were associated with a LR. These cases demonstrated a comparable morbidity and mortality with surgical DP, but shorter hospital stays. To aid in the management of these complex disease processes, early consultation of a multidisciplinary management service for these patients should be considered. Furthermore, the appropriate use of LR for infectious etiologies may lead to safer postoperative outcomes than previously thought. PMID: 30416790 [PubMe...
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The impact of histology and ground-glass opacity component on volume doubling time in primary lung cancer.
Authors: Obayashi K, Shimizu K, Nakazawa S, Nagashima T, Yajima T, Kosaka T, Atsumi J, Kawatani N, Yazawa T, Kaira K, Mogi A, Kuwano H Abstract Background: Correlations between volume doubling time (VDT) of primary lung cancer (PLC), histology, and ground glass opacity (GGO) components remain unclear. The purpose of this study was to evaluate and compare VDT of PLC in terms of histology and presence or absence of GGO components. Methods: A total of 371 surgically resected PLCs from 2003 to 2015 in our institute were retrospectively reviewed. The VDT was calculated both from the diameters of the entire tumor and...
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Lung function changes after chemoradiation therapy in patients with lung cancer treated by three usual platinum combinations.
Conclusions: According to our results, sequential chemoradiation causes significant changes in lung function parameters in patients with lung cancer. PMID: 30416792 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Comparison of additional minocycline versus iodopovidone pleurodesis during video-assisted thoracoscopic bleb resection for primary spontaneous pneumothorax: a propensity score-matched analysis.
Authors: Lee KH, Kim BT, Kim HK, Han KN, Choi YH Abstract Background: The optimal chemical agent for additional pleurodesis during video-assisted thoracoscopic surgery (VATS) bleb resection in primary spontaneous pneumothorax (PSP) remains controversial. We compared the efficacy and safety of iodopovidone with those of minocycline for additional chemical pleurodesis during VATS bleb resection. Methods: Of 332 patients who underwent VATS bleb resection, 299 patients diagnosed with PSP were enrolled in this study. The patients were divided into two groups according to the chemical agents used for additional pleur...
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Association of eosinophil-to-monocyte ratio with 1-month and long-term all-cause mortality in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Conclusions: EMR on admission was independently correlated with 1-month and long-term all-cause mortality in STEMI patients undergoing P-PCI, suggesting EMR as a potential simple, useful, and inexpensive index for risk stratification of STEMI patients. PMID: 30416794 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Expression and pathological significance of CC chemokine receptor 7 and its ligands in the airway of asthmatic rats exposed to cigarette smoke.
Authors: Zhang JF, Li Y, Zhang AZ, He QQ, Du YC, Cao W Abstract Background: Cigarette smoking aggravates the symptoms of asthma, leading to the rapid decline of lung function. Dendritic cells (DCs) and lymphocytes are considered initiating and promoting factors for the airway inflammation reactions of asthma. In addition, activation of CC chemokine receptor 7 (CCR7) by chemokine (C-C motif) ligand (CCL) 19 and 21 promotes DCs and T cells migration to lymphoid tissues during inflammation. We aimed to examine how cigarette smoke affects the expression of CCR7 in the lungs of asthmatic rats and explore the signaling m...
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Changes in non-small cell lung cancer diagnosis, molecular testing and prognosis 2011-2016.
Conclusions: Changes in diagnostic process in NSCLC have been observed towards a more precise stratification. Although short-term survival has not changed for advanced NSCLC, some of the newer therapeutic options are associated with increased survival in real-world scenarios. PMID: 30416796 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research