Comparison of preoperative scores predicting outcome in elderly undergoing lung malignancies resection.
Authors: Vaz Souza R, Bassi M, Mantovani S, Poggi C, Diso D, Vannucci J, Pagini A, Amore D, Venuta F, Anile M Abstract Background: Increased age of cancer patients is not an absolute contraindication to pulmonary resection. Different scores have been developed to determine the risk of morbidity and mortality. We have compared four scores in a series of elderly patients with primary or metastatic lung neoplasms who underwent pulmonary resection. Methods: Data from 150 patients with an age equal or more than 75 years were reviewed. Mean age was 78.3 (range, 75-86) years. Based on medical history and preoperative ...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Postoperative hypothermia after total aortic arch replacement in acute type A aortic dissection-multivariate analysis and risk identification for postoperative hypothermia occurrence.
Conclusions: The incidence of PH after total arch replacement in acute type A aortic dissection is relatively low. The independent risk factors of PH in this population include age and the intraoperative lowest bladder temperature. With comprehensive rewarming strategy upon arrival at the ICU, the PH is easy to be corrected, and the adverse effect of transient PH on early outcomes after arch surgery is minimal. PMID: 33447397 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Prediction of clinical response to omalizumab in moderate-to-severe asthma patients using the change in total serum IgE level.
Conclusions: A total week 4 serum IgE level:baseline level ratio ≥2 can predict the response to OMA in patients with moderate-to-severe asthma after 16 weeks of treatment with high likelihood. Monitoring changes of total IgE level in asthma patients treated OMA may be useful for predicting clinical response. PMID: 33447398 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Efficacy of cardiovascular surgery for Marfan syndrome patients: a single-center 15-year follow-up study.
Authors: Zhang B, Xue Q, Tang Y, Yu S, Fan X, Xu Z, Han L Abstract Background: Most Marfan syndrome (MFS) patients have thoracic aortic diseases which is the major cause of death. The aim of the study is to analyze the impact of different surgical procedures on prognosis of MFS patients. Methods: We retrospectively analyzed the results of hospitalization and long-term follow-up of MFS patients who underwent surgical intervention in our center. Results: Of the 135 MFS patients, 11 died during hospitalization (8.1%). There were no statistical differences in in-hospital mortality between the proximal surgery g...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

One-stage hybrid procedure for distal aortic arch disease: mid-term experience at a single center.
This study analyzes the outcomes of a one-stage hybrid procedure combining thoracic endovascular aortic repair (TEVAR) with extra-anatomic bypass in patients with distal aortic arch disease. Methods: This retrospective study collected 103 hybrid procedures combining TEVAR with extra-anatomic bypass (mean age, 62.2±9.3 years; 90 males) performed from January 2009 to January 2019 at Beijing Anzhen Hospital. We analyzed 30-day and mid-term outcomes including survival rate and the incidence of stroke, spinal cord injury (SCI), and endoleak. Results: Five deaths (4.6%) occurred within 30 days, including type I en...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Does short-term cessation of smoking before lung resections reduce the risk of complications?
Conclusions: Short-term smoking cessation intervention did not enough reduce the PPCs as much as in former or never smokers. PMID: 33447401 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Preoperative risk factors for successful extubation or not after lung transplantation.
Conclusions: Preoperative independent sputum clearance, preoperative ECMO, older than 65-year-old, and double lung or heart-LTx were four independent risk factors for unsuccessful extubation. Moreover, preoperative ECMO was the only independent risk factor for reintubation. PMID: 33447402 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Uniportal versus multiportal thoracoscopic sleeve lobectomy for the surgical treatment of centrally located lung cancer: a single institution experience.
Conclusions: Uniportal thoracoscopic sleeve lobectomy is technically feasible and safe for the treatment of centrally located lung cancer and may achieve superior surgical outcomes compared with the multiportal approach. PMID: 33447403 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Central location and risk of imaging occult mediastinal lymph node involvement in cN0T2-4 non-small cell lung cancer.
Authors: Guinde J, Bourdages-Pageau E, Ugalde PA, Fortin M Abstract Background: Appropriate pre-operative staging is a cornerstone in the treatment of non-small cell lung cancer (NSCLC). Central location and size greater than 3 cm are amongst indications for pre-operative invasive mediastinal staging but the quality of the evidence behind this recommendation is low. Methods: We retrospectively reviewed all cases of cT2-4N0M0 NSCLCL after CT and TEP-CT which underwent surgical resection with lymph node dissection or had a positive invasive pre-operative mediastinal staging in our institution from 2014 to 2018. ...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Factors associated with discrepancy between fresh frozen and permanent biopsy from medical thoracoscopy: single center analysis of 172 medical flexible thoracoscopy cases.
Conclusions: Taking fresh frozen sections during MT using a flex-rigid bronchoscope is a useful diagnostic modality with reliable sensitivity for malignancy. However, if the pre-procedural diagnosis is likely to be a malignancy other than lung cancer, and if severe adhesions are present in the pleural cavity, the final pathological confirmation should be determined based on permanent paraffin sections, not only on fresh frozen sections. PMID: 33447405 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Nationwide quality assessment of treatment for chronic obstructive pulmonary disease.
Conclusions: The PFT and inhaled bronchodilator prescription rates improved over the 3-year nationwide quality assessment period. PMID: 33447406 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The clinical suspicion of a leaking intrathoracic esophagogastric anastomosis: the role of CT imaging.
Authors: Plat VD, Bootsma BT, Straatman J, van den Bergh J, van Waesberghe JTM, Luttikhold J, Luyer MDP, van der Peet DL, Daams F Abstract Background: CT imaging is the primary diagnostic approach to assess the integrity of the intrathoracic anastomosis following Ivor Lewis esophagectomy. In the postoperative setting interpretation of CT findings, such as air and fluid collections, may be challenging. Establishment of a scoring system that incorporates CT findings to diagnose anastomotic leakage could assist radiologists and surgeons in the postoperative phase. Methods: Consecutive patients who underwent a CT s...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Changes in aortic arch geometry and the risk for Stanford B dissection.
Conclusions: This study demonstrates that TBAD was associated with longer lengths of aortic arch and with larger arch height and width. PMID: 33447408 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Developing a minimally-invasive anaesthesiological approach to non-intubated uniportal video-assisted thoracoscopic surgery in minor and major thoracic surgery.
Conclusions: niVATS appears to be safe in both minor and major thoracic procedures. A minimally invasive anaesthesiological approach foregoing central iv lines, arterial blood pressure measurement and urinary catheterization is feasible. Our niVATS protocol appears to be a viable alternative for both minor and major thoracic procedures in selected patients. PMID: 33447409 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The utility of three-dimensional computed tomography for prediction of tumor invasiveness in clinical stage IA lung adenocarcinoma.
Conclusions: 3D CT was equivalent to HRCT for predicting invasive adenocarcinoma and may be particularly useful for diagnosing lesions that are difficult to evaluate on HRCT. PMID: 33447410 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

First clinical experience with the novel cold storage SherpaPak ™ system for donor heart transportation.
Conclusions: The SherpaPak™ provides a constant temperature during transportation with permanent monitoring, never dropping below 4 °C. Organs transported with this novel device showed a normal perioperative function. PMID: 33447411 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Use of durable left ventricular assist devices for high-risk patients: Korean experience before insurance coverage.
Conclusions: All patients who received LVADs before insurance coverage had contraindications for HT. The overall outcomes were comparable with those reported in the international registry. PMID: 33447412 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The role of angiogenetic single-nucleotide polymorphisms in thymic malignancies and thymic benign lesions.
Conclusions: This is the first study investigating the angiogenetic polymorphisms in thymic benign lesions and TETs. SNPs analysis may represent a further asset in identification of patients who could benefit from anti-angiogenetic therapy. PMID: 33447413 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The safety and feasibility of three-dimension single-port video-assisted thoracoscopic surgery for the treatment of early-stage lung cancer.
Authors: Wang Y, Wang Z, Yao F Abstract Background: Video-assisted thoracoscopic surgery (VATS) has been widely used in the lung resections. Reports regarding three-dimension (3D) single-port VATS are very limited. The purpose of this study is to evaluate the perioperative outcomes of 3D single-port VATS in a single medical center. Methods: Totally 523 clinical stage I lung cancer patients underwent surgical resection through VATS operation between September 2016 and October 2017 in our single institution were retrospectively collected and 374 were enrolled. The comparison between 3D single-port VATS and conven...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Bleeding is the most common cause of unplanned return to operating room after lung cancer surgeries.
Conclusions: Bleeding is the most common indication which causes over 80% of UROR for lung cancer surgeries. Careful examination and complete hemostasis in surgery is key to reduce the risk of this unwanted complication. PMID: 33447415 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Utilities and placement skills of the incision protective sleeve in video-assisted thoracoscopic surgery (VATS).
Conclusions: The placement of the incision protective sleeve for VATS is affected by multiple factors, which are not only related to the patient's condition, chest wall thickness and intercostal space, but also closely related to the operator's experience and the manipulation adopted. PMID: 33447416 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Reduced expression of circRNA novel_circ_0005280 and its clinical value in the diagnosis of non-small cell lung cancer.
Conclusions: Novel_circ_0005280 may be a useful biomarker for the diagnosis and prognosis of NSCLC. PMID: 33447417 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Consistency of genotyping data from simultaneously collected plasma circulating tumor DNA and tumor-DNA in lung cancer patients.
Conclusions: Overall, our data show that circulating tumor DNA (ctDNA) was able to identify 75% of the identical information in driver genes, with higher rates of concordance in lung cancer patients with bone metastases or TP53 mutation-positive plasma samples. PMID: 33447418 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

A new solution model for cardiac medical image segmentation.
Conclusions: The results indicated that the proposed MOMP method can outperform all traditional models in terms of segmentation accuracy and stability, and is thus appropriate for use in medical imaging. PMID: 33447419 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Plasma thymidylate synthase and dihydrofolate reductase mRNA levels as potential predictive biomarkers of pemetrexed sensitivity in patients with advanced non-small cell lung cancer.
Conclusions: Low expression levels of plasma TS and DHFR mRNA confer increased tumour sensitivity to pemetrexed/cisplatin chemotherapy in patients with advanced NSCLC. The results suggested that plasma TS and DHFR mRNA levels are promising biomarkers for choosing patients who are likely to respond and benefit the most from pemetrexed-based chemotherapy. PMID: 33447420 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Circulating miR-130 is a potential bio signature for early prognosis of acute myocardial infarction.
Authors: Pan X, He Y, Chen Z, Yan G, Ma G Abstract Background: As distinctive leading reasons of death globally, acute myocardial infarction (AMI). Accounts for major death ratio, caused by coronary artery disease (CAD). Its diagnosis relies on the presenting clinical symptoms, electrocardiograms (ECGs), and levels of circulating biomarkers. Recent studies have implicated microRNAs (miRNAs) in the pathogenesis of many diseases, including AMI. The present study inquire into feature value of miR-130 in AMI patients. Methods: levels of expression of miR-130 in patient plasma, considered through simultaneous quanti...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Low expression of long non-coding RNA ARAP1-AS1 can inhibit lung cancer proliferation by inducing G0/G1 cell cycle organization.
Conclusions: LncRNA ARAP1-AS1 is highly expressed in lung cancer. Knocking down of this gene can significantly inhibit cell proliferation in vitro and in vivo, and can also cause G0/G1 cell cycle arrest by inhibiting the expression of cyclin D1. PMID: 33447422 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Effects of enteral nutrition support combined with enhanced recovery after surgery on the nutritional status, immune function, and prognosis of patients with esophageal cancer after Ivor-Lewis operation.
Authors: Ding H, Xu J, You J, Qin H, Ma H Abstract Background: Esophageal cancer (EC) with a high incidence of malnutrition is a highly malignant digestive tract tumor. We investigated the effect of enteral nutrition (EN) support combined with enhanced recovery after surgery (ERAS) on the nutritional status, immune function, and prognosis of patients with EC after Ivor-Lewis operation. Methods: One hundred patients were randomly divided into the observation group (n=42) and the control group (n=58). The patients in observation group were treated with EN combined with ERAS intervention after Ivor-Lewis operation...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Lobectomy with high-position single-intercostal two-port video-assisted thoracoscope for non-small cell lung cancer is a safe and effective surgical procedure.
Conclusions: Lobectomy with a high-position single-intercostal two-port video-assisted thoracoscope for NSCLC is a safe and effective surgical procedure. PMID: 33447424 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Bioinformatics analysis of differentially expressed genes in tumor and paracancerous tissues of patients with lung adenocarcinoma.
Conclusions: By analyzing the differential expression genes of lung adenocarcinoma and paracancerous normal tissues with bioinformatics, 11 genes with significant differential expression and significant influence on prognosis were identified. The findings may provide new concepts for developing diagnosis and treatment targets and prognosis markers for lung adenocarcinoma. PMID: 33447425 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The prognostic value of peak arterial lactate levels within 72 h of lung transplantation in identifying patient outcome.
Authors: Xu J, Qin Z, Wang Y, Hu C, Wang G, Gu Z, Yuan S, Chen J, Huang D, Wang Z Abstract Background: Lactic acidosis is often seen in lung transplantation (LTx). Postoperative lactate is frequently associated with poor outcome in postoperative and critically ill patients. Our aim was to evaluate the predictive value of postoperative peak lactate levels within 72 h of LTx for 30-day and late mortality. Methods: We evaluated patients who underwent LTx from January 2015 to September 2017. All admitted patients were classified according to the peak lactate level (PL) within 72 h of surgery: PL 10 mmol/L (Group 3)...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Association of renal cyst and type A acute aortic dissection with hypertension.
Conclusions: Renal cyst status correlates with the risk of TA-AAD with hypertension in middle-aged and elderly patients, and exhibits different degrees of vascular lesion in aortic dissection. We therefore suggest that different antihypertensive standards should be adopted in different renal cyst status to more effectively prevent aortic dissection. PMID: 33447427 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

International consensus statement on robot-assisted minimally invasive esophagectomy (RAMIE).
Authors: Li B, Yang Y, Toker A, Yu B, Kang CH, Abbas G, Soukiasian HJ, Li H, Daiko H, Jiang H, Fu J, Yi J, Kernstine K, Migliore M, Bouvet M, Ricciardi S, Chao YK, Kim YH, Wang Y, Yu Z, Abbas AE, Sarkaria IS, Li Z, Cooperative Group of International Expert Consensus on Robot-assisted Esophagectomy for Esophageal Cancer PMID: 33447428 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The 100 most cited papers on thymic epithelial tumours: a bibliometric analysis.
Authors: Qiu G, Wang F, Zhang H, Zheng Y, Wang Z, Wang Y Abstract Bibliometric analysis can help us analyse the most influential papers, authors, research institutions in a discipline or topic and analyse the impact of these papers on a specific field. Our purpose is to identify the 100 most cited papers about thymic epithelial tumours (TETs) and analyse their key characteristics. We use certain search terms in the Web of Science database to identify the 100 most cited papers, and analysed the first author, country of the first author, institution, journal, type of paper, number of citations, and citation rate. The...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Cone beam CT imaging for bronchoscopy: a technical review.
Authors: Setser R, Chintalapani G, Bhadra K, Casal RF Abstract Cone beam computed tomography (CBCT) is a well-established imaging modality with numerous proven applications across multiple clinical disciplines. More recently, CBCT has emerged as an important imaging tool for bronchoscopists, primarily used during transbronchial biopsy of peripheral pulmonary lesions (PPLS). For this application CBCT has proved useful in navigating devices to a target lesion, in confirming device tool-in-lesion, as well as during tissue acquisition. In addition, CBCT is poised to play an important role in trials evaluating bronchosc...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Risk factors and predictors associated with the severity of COVID-19 in China: a systematic review, meta-analysis, and meta-regression.
In conclusion, the severity of COVID-19 could be evaluated by, radiologic finding, some symptoms like dyspnea and hemoptysis, some laboratory indicators, and smoking history, especially the ex-smokers. Compared with non-severe patients, severe patients were more likely to have complications and comorbidities including hypertension, cardiovascular disease etc., which were the risk factors for the disease to be severer, but the chronic liver disease and chronic kidney disease were not associated the severity of COVID-19 in China. PMID: 33447431 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Exercise-based interventions for Indigenous adults with chronic lung disease in Australia, Canada, New Zealand, and USA: a systematic review.
Authors: Meharg DP, Gwynne K, Gilroy J, Alison JA Abstract Indigenous peoples in Australia, New Zealand, Canada, and the United States of America (USA) have a higher burden of chronic lung disease than non-Indigenous people. Exercised-based interventions, such as pulmonary rehabilitation, are highly effective to manage chronic lung disease. The outcomes of these interventions for Indigenous people require evaluation. The aim of this review was to critically appraise the literature on the impact of exercise-based interventions on quality of life, exercise capacity and health care utilisation in Indigenous adults wit...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Narrative review of the novel coronavirus SARS-CoV-2: update on genomic characteristics, transmissions and animal model.
Authors: Zhang Z, Zhang L, Zhu A, Wang Y, Guan W, Zeng Z, Sun J, Li F, Zhao J, Yang Z, Zhao J, Zhong N Abstract Two outbreaks of severe respiratory infection caused by severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) caused global pandemics and highlighted the importance of preparedness for respiratory CoVs. Recently, a third highly pathogenic CoV, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, Hubei, China and posed a public health crisis worldwide. Here, we focus on the recent advances of the nove...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Surgical staging and resection of malignant pleural mesothelioma.
Authors: Brown LB, Corl F, Blackmon SH PMID: 33447434 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Treatment of a lung lobectomy patient with severe post-surgical infection in the anterior thoracic wall by multiple debridement and drainage procedures: a case report.
Authors: Dai J, Greiffenstein P, Petrella F, Kim JJ, Marulli G, Fang Y, Zhou Y PMID: 33447435 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Pneumothorax as the presenting manifestation of COVID-19.
Authors: Ayazi S, Zebarjadi J, Grubic AD, Tahmasbi H, Ayazi K, Jobe BA PMID: 33447436 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Effect of an unsupervised walking program on tolerance to exercise in patients with chronic obstructive pulmonary disease.
Authors: Martin-Deleon R, Jurado-Garcia A, Arenas-De Larriva MDS, Feu-Collado N, Santos-Luna F, Jurado-Gamez B PMID: 33447437 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Endobronchial neurogenic tumor consisting of the features of a solitary circumscribed neuroma.
Authors: Tone K, Yorozu T, Hirano Y, Sasaki R, Kazuyori T, Kojima A, Kuwano K PMID: 33447438 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Effect of genotype-guided strategy in East Asian vs. Caucasian patients after percutaneous coronary intervention: insight from the TAILOR-PCI trial.
Authors: Kim HK, Sibbing D, Jeong YH PMID: 33447439 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

2019 ERS cough guideline: consensus and controversy.
Authors: Chen R, Qiu Z, Lai K PMID: 33447440 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Revealing the mysteries of thymoma.
Authors: Jovanovic D, Bilaceroglu S PMID: 33447441 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The role of postoperative radiotherapy for thymomas: a multicentric retrospective evaluation from three Italian centers and review of the literature.
Conclusions: Our results confirmed that patients with incompletely resected thymoma had the worst OS and DSS. High grade acute toxicity was not different between PORT and surgery alone. Other trials reported a significant benefit in OS, DSS and DFS in stage IIb-IV thymoma treated with PORT. PMID: 33447442 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Epidemiology of thymoma.
Authors: Rich AL Abstract Thymic tumours are a heterogeneous group of malignancies with a range of clinical presentations. The most common types are thymoma and thymic carcinoma, but overall it remains a rare cancer, and one without a clear aetiology. In this review of the epidemiology of the disease, the relationship between sex, age, and ethnicity is reviewed, along with limited evidence on the genetics of the condition. In terms of risk factors and potential causative factors, environmental exposures such as tobacco, radiation, alcohol, or diet, seem to be irrelevant, but there is some evidence linking the devel...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Genomic alterations in thymoma-molecular pathogenesis?
Authors: Oberndorfer F, Müllauer L Abstract Thymomas and thymic carcinomas (TCs) are neoplasms of thymic epithelial cells. Thymomas exhibit a low mutational burden and a few recurrently mutated genes. The most frequent missense mutation p.(Leu404His) affects the general transcription factor IIi (GTF2I) and is specific for thymic epithelial tumors (TETs). The clinically indolent types A and AB thymomas express the miRNA cluster C19MC. This miRNA cluster known to be the largest in the human genome, is-with expression otherwise restricted mostly to embryonal tissue-silenced in the more aggressive type B thymomas ...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Pathology of thymoma-where are we today?
Authors: Soomro IN Abstract Thymoma is the commonest epithelial neoplasm arising from thymus gland. Tumour is slow growing and in the absence of metastasis, surgery is the treatment of choice. Complete resection and bland morphology are important prognostic features. However, a significant proportion of these tumours tend to recur. These recurrent tumours, advanced thymomas and thymic carcinomas require platinum-based combination chemotherapy and radiotherapy. Efforts are being made to explore additional treatment modalities to control disease with the aim of improving survival. Number of thymoma cases worldwide is...
Source: Journal of Thoracic Disease - January 17, 2021 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research