Screening and identification of hub genes for ischemic cardiomyopathy and construction and validation of a clinical prognosis model using bioinformatics analysis
CONCLUSIONS: ICM is closely related to the changes of extracellular matrix (ECM) and oxidoreductase activity. The IL-6 and RHOA are expected to become potential targets for ICM treatment.PMID:38738215 | PMC:PMC11087634 | DOI:10.21037/jtd-23-1722 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Jing Wang Liying Tang Yuzhi Bai Xia Zhao Tian Tian Christos G Mihos Eva Maria Javier Delmo Pei Li Source Type: research

Patient selection, surgery and perioperative management in lung transplantation in Japan
J Thorac Dis. 2024 Apr 30;16(4):2613-2622. doi: 10.21037/jtd-23-374. Epub 2024 Apr 11.ABSTRACTLung transplantation (LT) is the final treatment option for end-stage respiratory diseases. The current prognosis of LT recipients in Japan is good, however, the reason for the good prognosis is unclear. In Japan, the waiting time for cadaveric LT is long, which is approximately 900 days on average. A long waiting time affects several aspects of LT. The diseases progress while they await LT in most patients are waiting for LT. Along with the disease progression of the disease, secondary pulmonary hypertension can newly emerge. Som...
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Chihiro Konoeda Masaaki Sato Source Type: research

Extracorporeal membrane oxygenation for general thoracic surgery: case series and narrative review
CONCLUSIONS: Enthusiasm for the use of ECMO has increased in recent years. What was once considered a salvage therapy in cases of life-threatening cardiopulmonary decompensation now plays an increasingly important role in the safe conduct of complex thoracic surgery procedures, provides much needed time for organ recovery, and offers acute resuscitation options. This shift broadens our ability to deliver life-saving care to patients that previously would have otherwise had limited treatment options.PMID:38738217 | PMC:PMC11087603 | DOI:10.21037/jtd-23-961 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Megan E Campany Britton B Donato Pedro Reck Dos Santos Cory M Alwardt Kristin Sell-Dottin Stephanie Blakeman Penny Hung Ayan Sen Patrick DeValeria Lara Schaheen Jonathan D'Cunha Source Type: research

Advancing coronary artery bypass grafting: the fasudil-nitroglycerin cocktail as a potential antispastic solution
J Thorac Dis. 2024 Apr 30;16(4):2694-2697. doi: 10.21037/jtd-23-1953. Epub 2024 Apr 12.NO ABSTRACTPMID:38738218 | PMC:PMC11087600 | DOI:10.21037/jtd-23-1953 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Michael Dashwood Domingos Souza G ökce Topal Source Type: research

Developing and validating machine learning-based prediction models for frailty occurrence in those with chronic obstructive pulmonary disease
CONCLUSIONS: The ML predictive model developed in this study is a useful and easy-to-use instrument for assessing the vulnerability risk of patients with COPD and may aid clinical physicians in screening high-risk patients.PMID:38738219 | PMC:PMC11087607 | DOI:10.21037/jtd-24-416 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Yong Chen Yonglin Yu Dongmei Yang Wenbo Zhang Vasileios Kouritas Xiaoju Chen Source Type: research

Prognostic impact of spread through air spaces in patients with ≤2 cm stage IA lung adenocarcinoma
CONCLUSIONS: STAS plays an important role in patient prognosis and is an independent risk factor for OS of patients with ≤2 cm stage IA LUAD. When STAS is positive, the choice of lobectomy with SLND may result in a better long-term prognosis for patients.PMID:38738220 | PMC:PMC11087609 | DOI:10.21037/jtd-24-444 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Xiao Chen Hangcheng Zhou Mingsheng Wu Meiqing Xu Tian Li Jun Wang Xiaohui Sun Yasuhiro Tsutani Mingran Xie Source Type: research

The ideal regional block after video-assisted thoracoscopic surgery: do we have it?
J Thorac Dis. 2024 Apr 30;16(4):2674-2676. doi: 10.21037/jtd-23-1924. Epub 2024 Apr 18.NO ABSTRACTPMID:38738221 | PMC:PMC11087612 | DOI:10.21037/jtd-23-1924 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Sarah Lumsden Emily Lai Juan P Cata Source Type: research

A validated model to predict spread through air space in lung adenocarcinoma
CONCLUSIONS: The outcome of STAS-positive patients was worse. The nomogram incorporating the identified CT features could be applied to facilitate individualized preoperative prediction of STAS and selection of rational therapy.PMID:38738222 | PMC:PMC11087620 | DOI:10.21037/jtd-23-1871 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Yuting Zheng Xiaoyu Han Hanting Li Qinyue Luo Chengyu Ding Kailu Zhang Jun Fan Wenjuan Zeng Heshui Shi Source Type: research

Not all that glitters is gold
J Thorac Dis. 2024 Apr 30;16(4):2681-2683. doi: 10.21037/jtd-24-38. Epub 2024 Apr 12.NO ABSTRACTPMID:38738223 | PMC:PMC11087643 | DOI:10.21037/jtd-24-38 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Marco Anile Francesco Ferrante Beatrice Zacchini Angelina Pernazza Massimiliano Bassi Jacopo Vannucci Federico Venuta Source Type: research

CXCR7 promotes pulmonary vascular remodeling via targeting p38/MMP2 pathway in pulmonary arterial hypertension
CONCLUSIONS: In summary, these findings suggest that CXCL12/CXCR7 plays a critical role in PAH, the therapy of which can be developed further by targeting its potential targets.PMID:38738224 | PMC:PMC11087638 | DOI:10.21037/jtd-24-331 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Jingjing Xu Shuai Miao Tianjun Wu Chunxiao Hu Dongxiao Huang Xin Zhang Source Type: research

Evaluation of a new surgical procedure for simultaneous resection of synchronous thoracic middle-lower segment esophageal and distal gastric cancers
CONCLUSIONS: The surgical procedure might be a new treatment option for selected patients with synchronous thoracic middle-lower segment EC and distal GC.PMID:38738225 | PMC:PMC11087610 | DOI:10.21037/jtd-23-1777 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Xusheng Ding Bin Li Hui Shen Zezhou Wang Longlong Shao Jiaqing Xiang Source Type: research

Health-related quality of life after minimal-invasive treatment of aortic valve stenosis in the elderly
CONCLUSIONS: Although PUMS-SAVR offers better technical outcomes with less permanent pacemaker implantation and less paravalvular leakage than TF-TAVI, it is still associated with more need for transfusion, longer ventilation-and intensive care unit-times, and prolonged hospital stay. In the elderly, PUMS-SAVR achieves inferior quality of life compared to TF-TAVI. Partial sternotomy reveals as the strongest risk factor of perceived health-level post-treatment. It remains to be revealed whether fast-track open heart surgery that maintains a fully intact sternum and allows immediate postoperative extubation-as performed thro...
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Ter ézia B Andrási Celine Schellenberg Alina Vasiloi Alannah C Gl ück Source Type: research

Effect of sternocleidomastoid flap repair and endoscopic injection of emulsified adipose tissue stromal vascular fraction in the treatment of refractory cervical anastomotic leak contaminating mediastinum
J Thorac Dis. 2024 Apr 30;16(4):2668-2673. doi: 10.21037/jtd-24-442. Epub 2024 Apr 29.ABSTRACTMediastinal infection caused by anastomotic leak is hard to cure, mainly because the poor drainage at the site of mediastinal infection leads to persistent cavity infection, which in turn becomes a refractory mediastinal abscess cavity after minimally invasive esophagectomy (MIE)-McKeown. Herein, we explored sternocleidomastoid (SCM) muscle flaps and emulsified adipose tissue stromal vascular fraction containing adipose-derived stem-cells to address this issue. We studied 10 patients with esophageal cancer who underwent MIE-McKeow...
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Baoxing Liu Haibo Ma Xingyu Liu Fabrizio Minervini Madhuri Rao Alessio Campisi Jiwei Cheng Wenqun Xing Source Type: research

Compatible with fibrotic hypersensitivity pneumonitis on high-resolution computed tomography: from the ATS/JRS/ALAT 2020 hypersensitivity pneumonitis guidelines
CONCLUSIONS: The two patterns in compatible with fibrotic HP of CT classification using the ATS/JRS/ALAT HP guidelines had different disease progression. Typical patterns were more frequent in the CHEST guidelines than the ATS/JRS/ALAT guidelines.PMID:38738228 | PMC:PMC11087622 | DOI:10.21037/jtd-23-1845 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Shota Kaburaki Ryo Okuda Tamiko Takemura Eri Hagiwara Masahiro Seike Akihiko Gemma Takashi Ogura Source Type: research

Echocardiographic right ventricular evaluation in cardiac surgery patients undergoing mitral valve reconstruction: a single center prospective observational study
CONCLUSIONS: Study early results report a significant reduction of RV-function after MV surgery as measured by TAPSE, & RV S', even when the FAC remains unchanged. Even though, this finding has limited prognostic implications during an uneventful surgical course.PMID:38738229 | PMC:PMC11087627 | DOI:10.21037/jtd-23-1727 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 13, 2024 Category: Respiratory Medicine Authors: Ali Haddad Ahmed Mohamed Sven Arends Bassam Ishak Olga Tsarenko Ilir Balaj Markus Kamler Thorsten Brenner Sharaf-Eldin Shehada Source Type: research