Long-term prognosis analysis of surgical therapy for bilateral synchronous multiple primary lung cancer: a follow-up of 293 cases
CONCLUSIONS: Patients with BSMPLC who underwent surgery generally had a favorable prognosis. Whether or not to remove all nodules bilaterally does not affect the patient's long-term prognosis, suggesting the need for an individualized surgical approach.PMID:38505060 | PMC:PMC10944773 | DOI:10.21037/jtd-23-1940 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Hui Zhang Lian Chen Feng Mao Jiantiao Li Masatsugu Hamaji Yoshihisa Shimada Chi Wan Koo Zuodong Song Liwei Song Shun Lu Source Type: research
A novel neoadjuvant therapy for early-stage non-small cell lung cancer in a mouse model
CONCLUSIONS: Based on our preclinical data, neoadjuvant therapy with intralesional RB injection generated immune memory and prevented the recurrence and metastasis of tumour in a lung cancer mouse model, which provides a new strategy for neoadjuvant treatment of early-stage NSCLC.PMID:38505061 | PMC:PMC10944762 | DOI:10.21037/jtd-23-1555 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Lanlin Zhang Jiangyuan Du Xianghua Wu Source Type: research
Dietary habits and nutrition status in esophageal cancer patients after esophageal reconstruction
CONCLUSIONS: Most patients with EC who underwent esophageal reconstruction recovered to regular dietary habits and stable nutrition status, while some may still suffer from gastrointestinal symptoms, anxiety, and dietary limitations.PMID:38505062 | PMC:PMC10944728 | DOI:10.21037/jtd-23-1266 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Yan He Ya-Ya Wu Wan Wei Yong-Bo Yang Yao Lin Liang Dai Source Type: research
Exploring diverse programmed cell-death patterns to develop a novel gene signature for predicting the prognosis of lung adenocarcinoma patients
CONCLUSIONS: This study identified a 9-gene signature (CDI) based on PCD-related genes that accurately predicted the prognosis of LUAD patients. The CDI could serve as a valuable prognostic indicator and guide personalized therapeutic strategies for LUAD.PMID:38505063 | PMC:PMC10944735 | DOI:10.21037/jtd-23-1275 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Zhanming Ma Yue Wang Yaxin Yu Fangqiu Fu Yang Zhang Source Type: research
Negative impact of ratio of the microvascular area to tumor area on the response to EGFR-TKI in non-small cell lung cancer with an < em > EGFR < /em > mutation
CONCLUSIONS: High RMV may critically affect EGFR-TKI resistance in patients with NSCLC and EGFR mutations.PMID:38505064 | PMC:PMC10944797 | DOI:10.21037/jtd-23-1723 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Moriyasu Anai Koichi Saruwatari Kosuke Imamura Kosuke Fujino Takayuki Jodai Shinya Sakata Shinji Iyama Yusuke Tomita Sho Saeki Hidenori Ichiyasu Koei Ikeda Makoto Suzuki Takuro Sakagami Source Type: research
Prognostic implication of Vasoactive Inotropic Score in adult patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation
CONCLUSIONS: Firstly, higher maximum level of VIS within the first 6 hours before ECMO initiation independently predicted poorer clinical outcomes in patients supported with ECMO for CS. Secondly, VIS exceeding 20 was significantly associated with increased risks of in-hospital mortality and 30-day mortality. Thirdly, when categorized by the cause of CS, a high VIS exhibited good predictive ability in patients with acute myocardial infarction, heart failure, and acute myocarditis.PMID:38505065 | PMC:PMC10944791 | DOI:10.21037/jtd-23-823 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Yao Hu Liangshan Wang Feng Yang Xiaomeng Wang Shuai Zhang Xing Hao Hong Wang Xiaotong Hou Source Type: research
Promotion of non-small cell lung cancer tumor growth by < em > FHL2 < /em > via inducing angiogenesis and vascular permeability
CONCLUSIONS: Our study revealed the role of FHL2 in NSCLC and the mechanism by which FHL2 promotes NSCLC tumorigenesis, providing novel insights into targeted therapy for NSCLC.PMID:38505066 | PMC:PMC10944754 | DOI:10.21037/jtd-23-1975 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Tengfei Chen Jun Chen Qiuyun Chen Zhipan Liang Liuying Pan Jun Zhao Xiaowei She Source Type: research
Fascial structure of the anterior mediastinum: the surgical figure of the sternopericardial ligament and the role of affixing the thymus to the pericardium
CONCLUSIONS: Our observation of the SPL showed differences from classical descriptions. The SPL is a sagittal fibrous collection showing a unique figure. Part of the SPL is thickened behind the thymus, anchoring the thymus to the pericardium in the midline. The SPL is part of the bottom of Grodinsky's Space 3 in the thorax. The SPL is visible in radiologic images, such as the anterior junction line on a plain chest radiograph.PMID:38505067 | PMC:PMC10944790 | DOI:10.21037/jtd-23-1602 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Kozo Nakanishi Hidenori Goto Source Type: research
Bioinformatics analysis of the prognostic role of alternative splicing data in lung adenocarcinoma
CONCLUSIONS: This study screened the ASE related to the prognosis of LUAD patients, and provided a theoretical basis for further study of the correlation between ASE and the prognosis of LUAD patients. It has provided new ideas for developing new biomarkers and therapeutic targets for LUAD patients.PMID:38505068 | PMC:PMC10944774 | DOI:10.21037/jtd-24-6 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Lingling Zhao Shuting He Ziwei Liu Zhibin Song Xiaochun Hou Ling Gai Source Type: research
The role of computed tomography prior to transcatheter aortic valve implantation: preprocedural planning and simultaneous coronary artery assessment
J Thorac Dis. 2024 Feb 29;16(2):833-838. doi: 10.21037/jtd-23-1384. Epub 2024 Feb 2.NO ABSTRACTPMID:38505069 | PMC:PMC10944746 | DOI:10.21037/jtd-23-1384 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Matthias Renker Grigorios Korosoglou Source Type: research
Modified surgical incision suturing technique in uniportal video-assisted thoracoscopic pulmonary resection
CONCLUSIONS: Our modified suture method reduces the chance of infection and splitting and the severity of postoperative incision scar formation, promoting early healing. It can be safely and effectively applied to the incision suture of uniportal thoracoscopic pulmonary resection, enhancing the rapid postoperative recovery of patients.PMID:38505070 | PMC:PMC10944763 | DOI:10.21037/jtd-23-1968 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Liuying Pan Tengfei Chen Zhipan Liang Piergiorgio Solli Benedetta Bedetti Kyung Soo Kim Xiaowei She Source Type: research
The effect of infectious diseases on lung transplantation in Japan
J Thorac Dis. 2024 Feb 29;16(2):1632-1644. doi: 10.21037/jtd-22-1884. Epub 2024 Feb 27.ABSTRACTLung transplantation in Japan is an increasingly accessible treatment option for end-stage lung disease; however, the lack of donor organs is a persisting challenge. Five- and 10-year survival rates of lung transplant recipients in Japan are comparable, if not superior, to international standards. The outcomes of lung transplantation in Japan are likely affected by multiple factors. Infectious disease complications are a significant burden to transplant recipients and account for approximately 30% of recipient mortality in Japan,...
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Satoshi Kitaura Koh Okamoto Source Type: research
Unraveling the intricacies of neoadjuvant immune checkpoint blockade in esophageal squamous cell carcinoma: a comprehensive single-cell perspective
J Thorac Dis. 2024 Feb 29;16(2):826-828. doi: 10.21037/jtd-23-1771. Epub 2024 Feb 20.NO ABSTRACTPMID:38505072 | PMC:PMC10944718 | DOI:10.21037/jtd-23-1771 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Gengyi Zou Junaid Anwar Melissa P Pizzi Ahmed Abdelhakeem Source Type: research
Surgical-decision making in the setting of unsuspected N2 disease: a cost-effectiveness analysis
CONCLUSIONS: Treatment of stage IIIa lung cancer requires the input of a multidisciplinary team who must consider cost, quality of life, and overall survival. As new treatments are developed, further analyses should be performed to determine optimal therapy.PMID:38505073 | PMC:PMC10944766 | DOI:10.21037/jtd-23-1538 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Brian Mitzman Thomas K Varghese Wallace L Akerley Richard E Nelson Source Type: research
Differential response to roflumilast in patients with chronic obstructive pulmonary disease: real-world evidence
CONCLUSIONS: The benefit of roflumilast in moderate-to-severe exacerbations was estimated to be greater in specific subgroups of patients with COPD. Personalised approaches to roflumilast based on clinical phenotypes would be effective for COPD.PMID:38505074 | PMC:PMC10944795 | DOI:10.21037/jtd-23-1129 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Hyun Woo Lee Jiyu Sun Hyo-Jin Lee Jung-Kyu Lee Tae Yeon Park Eun Young Heo Chin Kook Rhee Deog Kyeom Kim Source Type: research
