Global consequences of malignant CNS tumours: a call to action
Publication date: Available online 21 February 2019Source: The Lancet NeurologyAuthor(s): Lisa M DeAngelis (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 21, 2019 Category: Neurology Source Type: research

Global, regional, and national burden of brain and other CNS cancer, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
We report means and 95% uncertainty intervals (UIs) for incidence, mortality, and disability-adjusted life-years (DALYs) estimates for CNS cancers (according to the International Classification of Diseases tenth revision: malignant neoplasm of meninges, malignant neoplasm of brain, and malignant neoplasm of spinal cord, cranial nerves, and other parts of CNS) from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016. Data sources include vital registration and cancer registry data. Mortality was modelled using an ensemble model approach. Incidence was estimated by dividing the final mortality estimates by m...
Source: The Lancet Neurology - February 21, 2019 Category: Neurology Source Type: research

Fernando Cendes: targeting epilepsy by improving neuroimaging
Publication date: Available online 19 February 2019Source: The Lancet NeurologyAuthor(s): Tony Kirby (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 20, 2019 Category: Neurology Source Type: research

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications
Publication date: Available online 19 February 2019Source: The Lancet NeurologyAuthor(s): Amaia M Arranz, Bart De StrooperSummaryBackgroundAstrocytes, also called astroglia, maintain homoeostasis of the brain by providing trophic and metabolic support to neurons. They recycle neurotransmitters, stimulate synaptogenesis and synaptic neurotransmission, form part of the blood–brain barrier, and regulate regional blood flow. Although astrocytes have been known to display morphological alterations in Alzheimer's disease for more than a century, research has remained neurocentric. Emerging evidence suggests that these morp...
Source: The Lancet Neurology - February 20, 2019 Category: Neurology Source Type: research

Correction to Lancet Neurol 2019; 18: 231–33
Publication date: Available online 15 February 2019Source: The Lancet NeurologyAuthor(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 16, 2019 Category: Neurology Source Type: research

Intracerebral haemorrhage during alemtuzumab administration
Publication date: Available online 15 February 2019Source: The Lancet NeurologyAuthor(s): Christina J Azevedo, Christen Kutz, Amy Dix, Aaron Boster, Nerses Sanossian, Jeffrey Kaplan (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 16, 2019 Category: Neurology Source Type: research

An unparalleled assessment of the global burden of epilepsy
Publication date: Available online 14 February 2019Source: The Lancet NeurologyAuthor(s): W Allen Hauser (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 15, 2019 Category: Neurology Source Type: research

Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Publication date: Available online 14 February 2019Source: The Lancet NeurologyAuthor(s): Ettore Beghi, Giorgia Giussani, Foad Abd-Allah, Jemal Abdela, Ahmed Abdelalim, Haftom Niguse Abraha, Mina G. Adib, Sutapa Agrawal, Fares Alahdab, Ashish Awasthi, Yohanes Ayele, Miguel A Barboza, Abate Bekele Belachew, Belete Biadgo, Ali Bijani, Helen Bitew, Félix Carvalho, Yazan Chaiah, Ahmad Daryani, Huyen Phuc DoSummaryBackgroundSeizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality and residual disability). Data on the burden of epilepsy are needed for hea...
Source: The Lancet Neurology - February 15, 2019 Category: Neurology Source Type: research

Myelin: The Brain's Supercharger, Bernard Zalc, Florence Rosier. Oxford University Press, USA (2018), 328, $35, ISBN: 9780190686093
Publication date: Available online 14 February 2019Source: The Lancet NeurologyAuthor(s): Robert Stirrups (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 15, 2019 Category: Neurology Source Type: research

Complicated decisions on new migraine-prevention therapies
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): The Lancet Neurology (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Prasugrel or clopidogrel for long-term secondary stroke prevention?
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Graeme J Hankey (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Dementia risk after transient ischaemic attack and stroke
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Martin Dichgans (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

The long journey towards uniform epidemiological monitoring of TBI around the globe
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Marc Maegele (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

The risk of PML from natalizumab
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Bastian Tugemann (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

The risk of PML from natalizumab – Authors' reply
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Pei-Ran Ho, Nolan Campbell, Ih Chang (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Optimal stroke prevention in patients with PFO
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Maurizio Melis, Stefano Ricci, Danilo Toni, editorial committee of the Italian National Guidelines on Stroke (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Primum non nocere: a call for balance when reporting on CTE
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): William Stewart, Kieren Allinson, Safa Al-Sarraj, Corbin Bachmeier, Karen Barlow, Antonio Belli, Mark P Burns, Alan Carson, Fiona Crawford, Kristen Dams-O'Connor, Ramon Diaz-Arrastia, C Edward Dixon, Brian L Edlow, Scott Ferguson, Bruce Fischl, Rebecca D Folkerth, Steve Gentleman, Christopher C Giza, M Sean Grady, Adel Helmy (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Traumatic brain injury in China
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Ji-Yao Jiang, Guo-Yi Gao, Jun-Feng Feng, Qing Mao, Li-Gang Chen, Xiao-Feng Yang, Jin-Fang Liu, Yu-Hai Wang, Bing-Hui Qiu, Xian-Jian HuangSummaryChina has more patients with traumatic brain injury (TBI) than most other countries in the world, making this condition a major public health concern. Population-based mortality of TBI in China is estimated to be approximately 13 cases per 100 000 people, which is similar to the rates reported in other countries. The implementation of various measures, such as safety legislation for road traffi...
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Correction to Lancet Neurol 2019; 18: 177–84
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Correction to Lancet Neurol 2019; 18: 46–55
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Correction to Lancet Neurol 2018; 17: 47–53
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Outbreaks of acute flaccid myelitis? What neurologists need to know
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Adrian Burton (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Felix Mendelssohn's family's brain condition
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Tomislav Breitenfeld, Drako Breitenfeld, Hansjörg Bäzner (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Sarah Pendlebury
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Comparison of prasugrel and clopidogrel in patients with non-cardioembolic ischaemic stroke: a phase 3, randomised, non-inferiority trial (PRASTRO-I)
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Akira Ogawa, Kazunori Toyoda, Kazuo Kitagawa, Takanari Kitazono, Takehiko Nagao, Hiroshi Yamagami, Shinichiro Uchiyama, Norio Tanahashi, Masayasu Matsumoto, Kazuo Minematsu, Izumi Nagata, Masakatsu Nishikawa, Shinsuke Nanto, Kenji Abe, Yasuo Ikeda, PRASTRO-I Study GroupSummaryBackgroundThe effect of prasugrel in terms of the prevention of recurrence of ischaemic stroke is unknown. We investigated the non-inferiority of prasugrel to clopidogrel for prevention of ischaemic stroke, myocardial infarction, and death from other vascular causes...
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Sarah T Pendlebury, Peter M Rothwell, Oxford Vascular StudySummaryBackgroundRisk of dementia after stroke is a major concern for patients and carers. Reliable data for risk of dementia, particularly after transient ischaemic attack or minor stroke, are scarce. We studied the risks of, and risk factors for, dementia before and after transient ischaemic attack and stroke.MethodsThe Oxford Vascular Study is a prospective incidence study of all vascular events in a population of 92 728 people residing in Oxfordshire, UK. Patients with tran...
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Association between circadian rhythms and neurodegenerative diseases
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Yue Leng, Erik S Musiek, Kun Hu, Francesco P Cappuccio, Kristine YaffeSummaryDysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease. Manifestations of circadian rhythm disruptions differ according to the type and severity of neurodegenerative disease and, for some patients, occur before the onset of typical clinical symptoms of neu...
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

The Madwoman: a portrait of a choreic woman?
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Letizia Maria Cupini, Paolo Calabresi (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Periprocedural events dominate outcomes of carotid stenting and endarterectomy
Publication date: Available online 6 February 2019Source: The Lancet NeurologyAuthor(s): J David Spence (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 7, 2019 Category: Neurology Source Type: research

Long-term outcomes of stenting and endarterectomy for symptomatic carotid stenosis: a preplanned pooled analysis of individual patient data
Publication date: Available online 6 February 2019Source: The Lancet NeurologyAuthor(s): Thomas G Brott, David Calvet, George Howard, John Gregson, Ale Algra, Jean-Pierre Becquemin, Gert J de Borst, Richard Bulbulia, Hans-Henning Eckstein, Gustav Fraedrich, Jacoba P Greving, Alison Halliday, Jeroen Hendrikse, Olav Jansen, Jenifer H Voeks, Peter A Ringleb, Jean-Louis Mas, Martin M Brown, Leo H Bonati, Carotid Stenosis Trialists' CollaborationSummaryBackgroundThe risk of periprocedural stroke or death is higher after carotid artery stenting (CAS) than carotid endarterectomy (CEA) for the treatment of symptomatic carotid sten...
Source: The Lancet Neurology - February 7, 2019 Category: Neurology Source Type: research

Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial
Publication date: Available online 25 January 2019Source: The Lancet NeurologyAuthor(s): Gil I Wolfe, Henry J Kaminski, Inmaculada B Aban, Greg Minisman, Hui-Chien Kuo, Alexander Marx, Philipp Ströbel, Claudio Mazia, Joel Oger, J Gabriel Cea, Jeannine M Heckmann, Amelia Evoli, Wilfred Nix, Emma Ciafaloni, Giovanni Antonini, Rawiphan Witoonpanich, John O King, Said R Beydoun, Colin H Chalk, Alexandru C BarboiSummaryBackgroundThe Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone (MGTX) showed that thymectomy combined with prednisone was superior to prednisone alone in improving clinical...
Source: The Lancet Neurology - January 26, 2019 Category: Neurology Source Type: research

Thymectomy in myasthenia gravis: when, why, and how?
Publication date: Available online 25 January 2019Source: The Lancet NeurologyAuthor(s): Sonia Berrih-Aknin, Rozen Le Panse (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 26, 2019 Category: Neurology Source Type: research

A global perspective on the burden of multiple sclerosis
Publication date: Available online 21 January 2019Source: The Lancet NeurologyAuthor(s): Egon Stenager (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 22, 2019 Category: Neurology Source Type: research

Global, regional, and national burden of multiple sclerosis 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Publication date: Available online 21 January 2019Source: The Lancet NeurologyAuthor(s): Mitchell T Wallin, William J Culpepper, Emma Nichols, Zulfiqar A Bhutta, Tsegaye Tewelde Gebrehiwot, Simon I Hay, Ibrahim A Khalil, Kristopher J Krohn, Xiaofeng Liang, Mohsen Naghavi, Ali H Mokdad, Molly R Nixon, Robert C Reiner, Benn Sartorius, Mari Smith, Roman Topor-Madry, Andrea Werdecker, Theo Vos, Valery L. Feigin, Christopher J L MurraySummaryBackgroundMultiple sclerosis is the most common inflammatory neurological disease in young adults. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systemati...
Source: The Lancet Neurology - January 22, 2019 Category: Neurology Source Type: research

Correction to Lancet Neurol 2019; 18: 145–54
Publication date: Available online 18 January 2019Source: The Lancet NeurologyAuthor(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Association between pathological and MRI findings in multiple sclerosis
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): Massimo Filippi, Wolfgang Brück, Declan Chard, Franz Fazekas, Jeroen J G Geurts, Christian Enzinger, Simon Hametner, Tanja Kuhlmann, Paolo Preziosa, Àlex Rovira, Klaus Schmierer, Christine Stadelmann, Maria A Rocca, Attendees of the Correlation between Pathological and MRI findings in MS workshopSummaryPathological evaluation is the gold standard for identifying processes related to multiple sclerosis that explain disease manifestations, and for guiding the development of new treatments. However, there are limitations to t...
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Why are patients with epilepsy not getting treatment?
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): The Lancet Neurology (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

CVT-301 for Parkinson's disease: dose and effect size issues
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): Olivier Rascol (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Understanding frailty to predict and prevent dementia
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): Francesco Panza, Madia Lozupone, Giancarlo Logroscino (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Neurological disorder? No, Mannerism
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): Philippe Charlier, Donatella Lippi, Antonio Perciaccante, Otto Appenzeller, Raffaella Bianucci (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Openness, inclusion, and respect in dementia research
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): Adrian Thorogood, Anna Mäki-Petäjä-Leinonen, Gratien Dalpé, Chris Gastmans, Serge Gauthier (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Traumatic brain injury: global collaboration for a global challenge
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): Angelos G Kolias, Andres M Rubiano, Anthony Figaji, Franco Servadei, Peter J Hutchinson (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): Olga Ciccarelli, Jeffrey A Cohen, Stephen C Reingold, Brian G Weinshenker, Maria Pia Amato, Brenda Banwell, Frederik Barkhof, Bruce Bebo, Burkhard Becher, François Bethoux, Alexander Brandt, Wallace Brownlee, Peter Calabresi, Jeremy Chatway, Claudia Chien, Tanuja Chitnis, Olga Ciccarelli, Jeffrey Cohen, Giancarlo Comi, Jorge CorrealeSummarySpinal cord involvement is an important cause of disability in patients with multiple sclerosis or neuromyelitis optica spectrum disorders (NMOSDs). Multiple sclerosis and NMOSDs can be disti...
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Farrah Mateen
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Safety and efficacy of CVT-301 (levodopa inhalation powder) on motor function during off periods in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled phase 3 trial
In this study, we assessed the safety and efficacy of CVT-301, a self-administered levodopa oral inhalation powder, for the treatment of patients with Parkinson's disease during off periods.MethodsIn this randomised, double-blind, placebo-controlled, phase 3 trial, patients were recruited at 65 sites in Canada, Poland, Spain, and the USA. Eligible participants were patients with Parkinson's disease aged 30–85 years, who had daily off periods of 2 h or longer and showed an improvement of 25% or greater in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score from off to on state after use of an oral levodop...
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer's disease: a cross-sectional analysis of data from the Rush Memory and Aging Project
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): Lindsay M K Wallace, Olga Theou, Judith Godin, Melissa K Andrew, David A Bennett, Kenneth RockwoodSummaryBackgroundSome people with substantial Alzheimer's disease pathology at autopsy had shown few characteristic clinical symptoms or signs of the disease, whereas others with little Alzheimer's disease pathology have been diagnosed with Alzheimer's dementia. We aimed to examine whether frailty, which is associated with both age and dementia, moderates the relationship between Alzheimer's disease pathology and Alzheimer's dementia.Meth...
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): David R Beers, Stanley H AppelSummaryNeuroinflammation is a common pathological feature of many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and is characterised by activated CNS microglia and astroglia, proinflammatory peripheral lymphocytes, and macrophages. Data from clinical studies show that multiple genetic mutations linked to ALS (eg, mutations in SOD1, TARDBP, and C9orf72) enhance this neuroinflammation, which provides compelling evidence for immune dysregulation in the pathogenesis of ALS. Transg...
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Stanley Appel: a life in Russian proverbs
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): Adrian Burton (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 20, 2019 Category: Neurology Source Type: research

Implications of sleep disturbance and inflammation for Alzheimer's disease dementia
Publication date: Available online 17 January 2019Source: The Lancet NeurologyAuthor(s): Michael R Irwin, Michael V VitielloSummaryNearly half of all adults older than 60 years of age report sleep disturbance, as characterised either by reports of insomnia complaints with daytime consequences, dissatisfaction with sleep quality or quantity, or the diagnosis of insomnia disorder. Accumulating evidence shows that sleep disturbance contributes to cognitive decline and might also increase the risk of Alzheimer's disease dementia by increasing β-amyloid burden. That sleep disturbance would be a candidate risk factor for Al...
Source: The Lancet Neurology - January 18, 2019 Category: Neurology Source Type: research

The awakened girl
Publication date: Available online 20 December 2018Source: The Lancet NeurologyAuthor(s): Marco De Ambrogi (Source: The Lancet Neurology)
Source: The Lancet Neurology - December 21, 2018 Category: Neurology Source Type: research