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No one knows what tomorrow might bring
Publication date: Available online 13 April 2018 Source:The Lancet Neurology Author(s): Jules Morgan (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 14, 2018 Category: Neurology Source Type: research

Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned
Publication date: May 2018 Source:The Lancet Neurology, Volume 17, Issue 5 Author(s): Eugene O Major, Tarek A Yousry, David B Clifford Progressive multifocal leukoencephalopathy (PML) is a rare, devastating demyelinating disease of the CNS caused by the JC virus (JCV) that occurs in patients with compromised immune systems. Detection of PML in systemically immunocompetent patients with multiple sclerosis treated with natalizumab points to a role for this drug in the pathophysiology of PML. Emerging knowledge of the cellular and molecular biology of JCV infection and the pathogenesis of PML—including interplay of thi...
Source: The Lancet Neurology - April 13, 2018 Category: Neurology Source Type: research

Impairment of creativity by anaesthesia
Publication date: May 2018 Source:The Lancet Neurology, Volume 17, Issue 5 Author(s): Justo García de Yébenes (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 13, 2018 Category: Neurology Source Type: research

Sven van der Lee
Publication date: May 2018 Source:The Lancet Neurology, Volume 17, Issue 5 (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 13, 2018 Category: Neurology Source Type: research

Classification of epilepsies in the 18th century
Publication date: May 2018 Source:The Lancet Neurology, Volume 17, Issue 5 Author(s): Francesco Brigo, Nicola Luigi Bragazzi, Simona Lattanzi, Raffaele Nardone, Mariano Martini, Eugen Trinka (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 13, 2018 Category: Neurology Source Type: research

Intravenous versus subcutaneous immunoglobulin – Authors' reply
Publication date: May 2018 Source:The Lancet Neurology, Volume 17, Issue 5 Author(s): Ivo N van Schaik, Orell Mielke (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 13, 2018 Category: Neurology Source Type: research

Intravenous versus subcutaneous immunoglobulin
Publication date: May 2018 Source:The Lancet Neurology, Volume 17, Issue 5 Author(s): Ravi Uniyal, Ravindra Kumar Garg, Hardeep Singh Malhotra, Neeraj Kumar, Shweta Pandey (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 13, 2018 Category: Neurology Source Type: research

Understanding risk of PML through multiple sclerosis
Publication date: May 2018 Source:The Lancet Neurology, Volume 17, Issue 5 Author(s): Roland Martin (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 13, 2018 Category: Neurology Source Type: research

Evidence-based care in Duchenne muscular dystrophy
Publication date: May 2018 Source:The Lancet Neurology, Volume 17, Issue 5 Author(s): Craig M McDonald, Eugenio Mercuri (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 13, 2018 Category: Neurology Source Type: research

Prediction to prevention in Alzheimer's disease and dementia
Publication date: May 2018 Source:The Lancet Neurology, Volume 17, Issue 5 Author(s): Carole Dufouil, M Maria Glymour (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 13, 2018 Category: Neurology Source Type: research

Hope and foresight for your patients with ALS
Publication date: May 2018 Source:The Lancet Neurology, Volume 17, Issue 5 Author(s): The Lancet Neurology (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 13, 2018 Category: Neurology Source Type: research

Clinical innovation in stroke: getting the simple things right
Publication date: Available online 10 April 2018 Source:The Lancet Neurology Author(s): Peter M Rothwell (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 11, 2018 Category: Neurology Source Type: research

Ingrid Scheffer: improving patient outcomes in epilepsy
Publication date: Available online 5 April 2018 Source:The Lancet Neurology Author(s): Tony Kirby (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 6, 2018 Category: Neurology Source Type: research

James Ironside: modest manner, mighty impact
Publication date: Available online 5 April 2018 Source:The Lancet Neurology Author(s): Ruth Williams (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 6, 2018 Category: Neurology Source Type: research

What if you knew the prognosis of your patients with ALS?
Publication date: Available online 26 March 2018 Source:The Lancet Neurology Author(s): Hiroshi Mitsumoto (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 27, 2018 Category: Neurology Source Type: research

Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model
Publication date: Available online 26 March 2018 Source:The Lancet Neurology Author(s): Henk-Jan Westeneng, Thomas P A Debray, Anne E Visser, Ruben P A van Eijk, James P K Rooney, Andrea Calvo, Sarah Martin, Christopher J McDermott, Alexander G Thompson, Susana Pinto, Xenia Kobeleva, Angela Rosenbohm, Beatrice Stubendorff, Helma Sommer, Bas M Middelkoop, Annelot M Dekker, Joke J F A van Vugt, Wouter van Rheenen, Alice Vajda, Mark Heverin, Mbombe Kazoka, Hannah Hollinger, Marta Gromicho, Sonja Körner, Thomas M Ringer, Annekathrin Rödiger, Anne Gunkel, Christopher E Shaw, Annelien L Bredenoord, Michael A van Es, P...
Source: The Lancet Neurology - March 27, 2018 Category: Neurology Source Type: research

Diagnosis and assessment of neuropathic pain through questionnaires
Publication date: Available online 26 March 2018 Source:The Lancet Neurology Author(s): Nadine Attal, Didier Bouhassira, Ralf Baron Neuropathic pain—pain caused by a lesion or disease of the somatosensory nervous system—is underdiagnosed and difficult to treat. However, development of easy-to-use questionnaires based mainly on self-reports of symptoms has improved diagnosis and management. Two types of questionnaires (screening and assessment) have been validated, and rapidly translated and revalidated in several languages, probably because of their simplicity. Screening questionnaires help clinicians to ident...
Source: The Lancet Neurology - March 27, 2018 Category: Neurology Source Type: research

Frederik Barkhof: building bridges between disciplines
Publication date: Available online 23 March 2018 Source:The Lancet Neurology Author(s): Jules Morgan (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 24, 2018 Category: Neurology Source Type: research

How far away the cornfield. Dennis Spencer's journey
Publication date: Available online 23 March 2018 Source:The Lancet Neurology Author(s): Adrian Burton (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 24, 2018 Category: Neurology Source Type: research

Accelerated long-term forgetting in asymptomatic APOE ε4 carriers
Publication date: Available online 21 March 2018 Source:The Lancet Neurology Author(s): Jacqueline F Zimmermann, Christopher R Butler (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 22, 2018 Category: Neurology Source Type: research

The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study
Publication date: Available online 16 March 2018 Source:The Lancet Neurology Author(s): Sven J van der Lee, Frank J Wolters, M Kamran Ikram, Albert Hofman, M Arfan Ikram, Najaf Amin, Cornelia M van Duijn Background Alzheimer's disease is one of the most heritable diseases in elderly people and the most common type of dementia. In addition to the major genetic determinant of Alzheimer's disease, the APOE gene, 23 genetic variants have been associated with the disease. We assessed the effects of these variants and APOE on cumulative risk and age at onset of Alzheimer's disease and all-cause dementia. Methods We studied inci...
Source: The Lancet Neurology - March 18, 2018 Category: Neurology Source Type: research

The storm and stress in the adolescent brain
Publication date: Available online 15 March 2018 Source:The Lancet Neurology Author(s): Robert Stirrups (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 16, 2018 Category: Neurology Source Type: research

International Classification of Headache Disorders
Publication date: Available online 14 March 2018 Source:The Lancet Neurology Author(s): Jes Olesen (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 15, 2018 Category: Neurology Source Type: research

The roles of surgery and technology in understanding focal epilepsy and its comorbidities
Publication date: April 2018 Source:The Lancet Neurology, Volume 17, Issue 4 Author(s): Dennis D Spencer, Jason L Gerrard, Hitten P Zaveri Intracranial electrophysiological recording in patients with refractory focal epilepsy is the gold standard for defining epileptogenic tissue. Although the concordance of intracranial electrophysiology, structural MRI, and pathology can identify brain regions for resection, complete seizure control after surgery is not achieved in all patients with focal epilepsy. Repetitive identical behavioural seizures suggest one onset area, but epileptogenesis might be distributed and connected by...
Source: The Lancet Neurology - March 14, 2018 Category: Neurology Source Type: research

Survival in patients with spinocerebellar ataxia types 1, 2, 3, and 6 (EUROSCA): a longitudinal cohort study
Publication date: April 2018 Source:The Lancet Neurology, Volume 17, Issue 4 Author(s): Alhassane Diallo, Heike Jacobi, Arron Cook, Robyn Labrum, Alexandra Durr, Alexis Brice, Perrine Charles, Cecilia Marelli, Caterina Mariotti, Lorenzo Nanetti, Marta Panzeri, Maria Rakowicz, Anna Sobanska, Anna Sulek, Tanja Schmitz-Hübsch, Ludger Schöls, Holger Hengel, Bela Melegh, Alessandro Filla, Antonella Antenora, Jon Infante, José Berciano, Bart P van de Warrenburg, Dagmar Timmann, Sylvia Boesch, Massimo Pandolfo, Jörg B Schulz, Peter Bauer, Paola Giunti, Jun-Suk Kang, Thomas Klockgether, Sophie Tezenas du Mon...
Source: The Lancet Neurology - March 14, 2018 Category: Neurology Source Type: research

Yogeshwar Kalkonde
Publication date: April 2018 Source:The Lancet Neurology, Volume 17, Issue 4 (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 14, 2018 Category: Neurology Source Type: research

Hemiplegic migraine and stroke in Mary Shelley
Publication date: April 2018 Source:The Lancet Neurology, Volume 17, Issue 4 Author(s): Philippe Charlier, Otto Appenzeller, Saudamini Deo, Antonio Perciaccante, Raffaella Bianucci (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 14, 2018 Category: Neurology Source Type: research

MPTP-induced parkinsonism: an historical case series
Publication date: April 2018 Source:The Lancet Neurology, Volume 17, Issue 4 Author(s): Jorik Nonnekes, Bart Post, James W Tetrud, J William Langston, Bastiaan R Bloem (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 14, 2018 Category: Neurology Source Type: research

Outcome assessment after traumatic brain injury – Authors' reply
Publication date: April 2018 Source:The Lancet Neurology, Volume 17, Issue 4 Author(s): Lindsay Wilson, Nicole von Steinbuechel, David K Menon, Andrew I R Maas (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 14, 2018 Category: Neurology Source Type: research

Outcome assessment after traumatic brain injury
Publication date: April 2018 Source:The Lancet Neurology, Volume 17, Issue 4 Author(s): Thomas McMillan, Erin D Bigler, Graham Teasdale, Jennie Ponsford, Gordon D Murray (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 14, 2018 Category: Neurology Source Type: research

Mapping brain networks in patients with focal epilepsy
Publication date: April 2018 Source:The Lancet Neurology, Volume 17, Issue 4 Author(s): Imad M Najm (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 14, 2018 Category: Neurology Source Type: research

A crystal ball for survival for spinocerebellar ataxias?
Publication date: April 2018 Source:The Lancet Neurology, Volume 17, Issue 4 Author(s): Tetsuo Ashizawa (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 14, 2018 Category: Neurology Source Type: research

Accelerating research for Parkinson's disease
Publication date: April 2018 Source:The Lancet Neurology, Volume 17, Issue 4 Author(s): The Lancet Neurology (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 14, 2018 Category: Neurology Source Type: research

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension
Publication date: Available online 12 March 2018 Source:The Lancet Neurology Author(s): Raju Kapoor, Pei-Ran Ho, Nolan Campbell, Ih Chang, Aaron Deykin, Fiona Forrestal, Nisha Lucas, Bei Yu, Douglas L Arnold, Mark S Freedman, Myla D Goldman, Hans-Peter Hartung, Eva Kubala Havrdová, Douglas Jeffery, Aaron Miller, Finn Sellebjerg, Diego Cadavid, Dan Mikol, Deborah Steiner Background Although several disease-modifying treatments are available for relapsing multiple sclerosis, treatment effects have been more modest in progressive multiple sclerosis and have been observed particularly in actively relapsing subgroups or...
Source: The Lancet Neurology - March 13, 2018 Category: Neurology Source Type: research

Natalizumab in secondary progressive multiple sclerosis
Publication date: Available online 12 March 2018 Source:The Lancet Neurology Author(s): Gilles Edan (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 13, 2018 Category: Neurology Source Type: research

Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study
Publication date: Available online 7 March 2018 Source:The Lancet Neurology Author(s): Ton Fang, Ahmad Al Khleifat, Jacques-Henri Meurgey, Ashley Jones, P Nigel Leigh, Gilbert Bensimon, Ammar Al-Chalabi Background Riluzole is the only drug to prolong survival for amyotrophic lateral sclerosis (ALS) and, at a dose of 100 mg, was associated with a 35% reduction in mortality in a clinical trial. A key question is whether the survival benefit occurs at an early stage of disease, late stage, or is spread throughout the course of the disease. To address this question, we used the King's clinical staging system to do a retrospec...
Source: The Lancet Neurology - March 8, 2018 Category: Neurology Source Type: research

Riluzole, disease stage and survival in ALS
Publication date: Available online 7 March 2018 Source:The Lancet Neurology Author(s): Thanuja Dharmadasa, Matthew C Kiernan (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 8, 2018 Category: Neurology Source Type: research

White matter is what matters after cardiac arrest
Publication date: Available online 27 February 2018 Source:The Lancet Neurology Author(s): Tobias Cronberg (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 28, 2018 Category: Neurology Source Type: research

Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study
Publication date: Available online 27 February 2018 Source:The Lancet Neurology Author(s): Bruno Dubois, Stephane Epelbaum, Francis Nyasse, Hovagim Bakardjian, Geoffroy Gagliardi, Olga Uspenskaya, Marion Houot, Simone Lista, Federica Cacciamani, Marie-Claude Potier, Anne Bertrand, Foudil Lamari, Habib Benali, Jean-François Mangin, Olivier Colliot, Remy Genthon, Marie-Odile Habert, Harald Hampel Background Improved understanding is needed of risk factors and markers of disease progression in preclinical Alzheimer's disease. We assessed associations between brain β-amyloidosis and various cognitive and neuroimag...
Source: The Lancet Neurology - February 28, 2018 Category: Neurology Source Type: research

One step towards dementia prevention
Publication date: Available online 27 February 2018 Source:The Lancet Neurology Author(s): Giovanni B Frisoni, Frank Jessen (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 28, 2018 Category: Neurology Source Type: research

Use of brain diffusion tensor imaging for the prediction of long-term neurological outcomes in patients after cardiac arrest: a multicentre, international, prospective, observational, cohort study
This study was registered with ClinicalTrials.gov, number NCT00577954. Findings Between Oct 1, 2006, and June 30, 2014, 185 patients were enrolled in the derivation cohort, of whom 150 had an interpretable multimodal MRI and were included in the analysis. 33 (22%) patients had a favourable neurological outcome at 6 months. Prognostic accuracy, as quantified by the area under the ROC curve, was significantly higher with the normalised WWM-FA value (area under the ROC curve 0·95, 95% CI 0·91–0·98) than with the standard criteria for unfavourable outcome or other MRI sequences. In a subsequent valid...
Source: The Lancet Neurology - February 28, 2018 Category: Neurology Source Type: research

Two steps forward for myelin repair in multiple sclerosis
Publication date: Available online 26 February 2018 Source:The Lancet Neurology Author(s): Andrew V Caprariello, Peter K Stys (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 27, 2018 Category: Neurology Source Type: research

The hard problem of consciousness: understanding our reality
Publication date: Available online 26 February 2018 Source:The Lancet Neurology Author(s): Jules Morgan (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 27, 2018 Category: Neurology Source Type: research

Increasing understanding of encephalitis
Publication date: Available online 21 February 2018 Source:The Lancet Neurology Author(s): Ava Easton (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 22, 2018 Category: Neurology Source Type: research

Advances in the diagnosis and treatment of fungal infections of the CNS
Publication date: Available online 21 February 2018 Source:The Lancet Neurology Author(s): Stefan Schwartz, Dimitrios P Kontoyiannis, Thomas Harrison, Markus Ruhnke Fungal infections of the CNS are challenging to treat and their optimal management requires knowledge of their epidemiology, host characteristics, diagnostic criteria, and therapeutic options. Aspergillus and Cryptococcus species predominate among fungal infections of the CNS. Most of these fungi are ubiquitous, but some have restricted geographical distribution. Fungal infections of the CNS usually originate from primary sites outside the CNS (eg, fungal pneu...
Source: The Lancet Neurology - February 22, 2018 Category: Neurology Source Type: research

The birth of consciousness: I think, therefore I am?
Publication date: Available online 17 February 2018 Source:The Lancet Neurology Author(s): Vijay Shankar Balakrishnan (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 18, 2018 Category: Neurology Source Type: research

The SeLECT score is useful to predict post-stroke epilepsy
Publication date: Available online 16 February 2018 Source:The Lancet Neurology Author(s): Marian Galovic, Nico Döhler, Mark R Keezer, John S Duncan, Josemir W Sander, Matthias J Koepp, Barbara Tettenborn (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 17, 2018 Category: Neurology Source Type: research

The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study
Publication date: Available online 16 February 2018 Source:The Lancet Neurology Author(s): Shu-Ying Liu, Daryl J Wile, Jessie Fanglu Fu, Jason Valerio, Elham Shahinfard, Siobhan McCormick, Rostom Mabrouk, Nasim Vafai, Jess McKenzie, Nicole Neilson, Alexandra Perez-Soriano, Julieta E Arena, Mariya Cherkasova, Piu Chan, Jing Zhang, Cyrus P Zabetian, Jan O Aasly, Zbigniew K Wszolek, Martin J McKeown, Michael J Adam, Thomas J Ruth, Michael Schulzer, Vesna Sossi, A Jon Stoessl Background Markers of neuroinflammation are increased in some patients with LRRK2 Parkinson's disease compared with individuals with idiopathic Parkinso...
Source: The Lancet Neurology - February 17, 2018 Category: Neurology Source Type: research

Hypercholinergic activity in LRRK2 Parkinson's disease
Publication date: Available online 16 February 2018 Source:The Lancet Neurology Author(s): Nicolaas I Bohnen, Roger L Albin (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 17, 2018 Category: Neurology Source Type: research

Expecting exoskeletons for more than spinal cord injury
Publication date: Available online 13 February 2018 Source:The Lancet Neurology Author(s): Adrian Burton (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 14, 2018 Category: Neurology Source Type: research