Risk predictors to limit neuronal loss after intracerebral haemorrhage
Publication date: Available online 17 August 2018Source: The Lancet NeurologyAuthor(s): M Edip Gurol (Source: The Lancet Neurology)
Source: The Lancet Neurology - August 18, 2018 Category: Neurology Source Type: research

Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data
Publication date: Available online 14 August 2018Source: The Lancet NeurologyAuthor(s): Rustam Al-Shahi Salman, Joseph Frantzias, Robert J Lee, Patrick D Lyden, Thomas W K Battey, Alison M Ayres, Joshua N Goldstein, Stephan A Mayer, Thorsten Steiner, Xia Wang, Hisatomi Arima, Hitoshi Hasegawa, Makoto Oishi, Daniel A Godoy, Luca Masotti, Dar Dowlatshahi, David Rodriguez-Luna, Carlos A Molina, Dong-Kyu Jang, Antonio DavalosSummaryBackgroundIntracerebral haemorrhage growth is associated with poor clinical outcome and is a therapeutic target for improving outcome. We aimed to determine the absolute risk and predictors of intra...
Source: The Lancet Neurology - August 15, 2018 Category: Neurology Source Type: research

Selective autophagy as a potential therapeutic target for neurodegenerative disorders
Publication date: September 2018Source: The Lancet Neurology, Volume 17, Issue 9Author(s): Aurora Scrivo, Mathieu Bourdenx, Olatz Pampliega, Ana Maria CuervoSummaryCells rely on surveillance systems such as autophagy to handle protein alterations and organelle damage. Dysfunctional autophagy, an evolutionarily conserved cellular mechanism for degradation of intracellular components in lysosomes, frequently leads to neurodegeneration. The neuroprotective effect of autophagy stems from its ability to eliminate pathogenic forms of proteins such as α-synuclein or tau. However, the same pathogenic proteins often affect di...
Source: The Lancet Neurology - August 15, 2018 Category: Neurology Source Type: research

A wake-up call to improve care for patients with meningitis
Publication date: September 2018Source: The Lancet Neurology, Volume 17, Issue 9Author(s): The Lancet Neurology (Source: The Lancet Neurology)
Source: The Lancet Neurology - August 15, 2018 Category: Neurology Source Type: research

Neurological treatment goes bacterial
Publication date: September 2018Source: The Lancet Neurology, Volume 17, Issue 9Author(s): Ralf Baron, Julia Forstenpointner (Source: The Lancet Neurology)
Source: The Lancet Neurology - August 15, 2018 Category: Neurology Source Type: research

Corrections
Publication date: September 2018Source: The Lancet Neurology, Volume 17, Issue 9Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - August 15, 2018 Category: Neurology Source Type: research

EURAP registry: inadequate monitoring of prescribed drugs in pregnancy
Publication date: September 2018Source: The Lancet Neurology, Volume 17, Issue 9Author(s): Alain Braillon, Susan Bewley (Source: The Lancet Neurology)
Source: The Lancet Neurology - August 15, 2018 Category: Neurology Source Type: research

EURAP registry: inadequate monitoring of prescribed drugs in pregnancy – Authors' reply
Publication date: September 2018Source: The Lancet Neurology, Volume 17, Issue 9Author(s): Torbjörn Tomson, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout, Emilio Perucca, Anne Sabers, Sanjeev V Thomas, Frank Vajda (Source: The Lancet Neurology)
Source: The Lancet Neurology - August 15, 2018 Category: Neurology Source Type: research

Epidemiology, aetiology, and management of ischaemic stroke in young adults
Publication date: September 2018Source: The Lancet Neurology, Volume 17, Issue 9Author(s): Merel S Ekker, Esther M Boot, Aneesh B Singhal, Kay Sin Tan, Stephanie Debette, Anil M Tuladhar, Frank-Erik de LeeuwSummaryEpidemiological evidence suggests that the incidence of ischaemic stroke in young adults (18–50 years) has increased substantially. These patients have a long life expectancy after stroke, and the costs of long-term care pose huge challenges to health-care systems. Although the current recommendations for treatment of young and old (>50 years) patients with stroke are similar, the optimal management of y...
Source: The Lancet Neurology - August 15, 2018 Category: Neurology Source Type: research

Traditional Chinese medicine for ischaemic stroke
Publication date: September 2018Source: The Lancet Neurology, Volume 17, Issue 9Author(s): Tianlong Liu, Yi Ding, Aidong Wen (Source: The Lancet Neurology)
Source: The Lancet Neurology - August 15, 2018 Category: Neurology Source Type: research

Rahul S Desikan
Publication date: September 2018Source: The Lancet Neurology, Volume 17, Issue 9Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - August 15, 2018 Category: Neurology Source Type: research

Classification and management of adult inflammatory myopathies
Publication date: September 2018Source: The Lancet Neurology, Volume 17, Issue 9Author(s): Albert Selva-O'Callaghan, Iago Pinal-Fernandez, Ernesto Trallero-Araguás, José César Milisenda, Josep Maria Grau-Junyent, Andrew L MammenSummaryInflammatory myopathies, collectively known as myositis, are heterogeneous disorders characterised by muscle inflammation, and frequently accompanied by extramuscular manifestations that affect the skin, lung, and joints. Patients with inflammatory myopathies were previously classified as having dermatomyositis if characteristic rashes accompanied the muscle involvement, ...
Source: The Lancet Neurology - August 15, 2018 Category: Neurology Source Type: research

Claw hand in a Renaissance portrait
Publication date: September 2018Source: The Lancet Neurology, Volume 17, Issue 9Author(s): Alla A Vein, Alexander Mouret (Source: The Lancet Neurology)
Source: The Lancet Neurology - August 15, 2018 Category: Neurology Source Type: research

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study
Publication date: Available online 6 August 2018Source: The Lancet NeurologyAuthor(s): Hyun-Sik Yang, Lei Yu, Charles C White, Lori B Chibnik, Jasmeer P Chhatwal, Reisa A Sperling, David A Bennett, Julie A Schneider, Philip L De JagerSummaryBackgroundTransactive response DNA-binding protein of 43 kDa (TDP-43) proteinopathy in older adults frequently coexists with Alzheimer's disease pathology and hippocampal sclerosis. It is unclear whether there is a link between APOE ε4 and TDP-43 proteinopathy, and the role of APOE ε4 in the association of TDP-43 proteinopathy with hippocampal sclerosis remains to be exa...
Source: The Lancet Neurology - August 7, 2018 Category: Neurology Source Type: research

Fitting TDP-43 into the APOE ε4 and neurodegeneration story
Publication date: Available online 6 August 2018Source: The Lancet NeurologyAuthor(s): Keith A Josephs (Source: The Lancet Neurology)
Source: The Lancet Neurology - August 7, 2018 Category: Neurology Source Type: research

Harry T Orr: decoding spinocerebellar ataxias
Publication date: Available online 6 August 2018Source: The Lancet NeurologyAuthor(s): Tony Kirby (Source: The Lancet Neurology)
Source: The Lancet Neurology - August 7, 2018 Category: Neurology Source Type: research

At last, a randomised controlled trial of apomorphine infusion
Publication date: Available online 25 July 2018Source: The Lancet NeurologyAuthor(s): Peter A LeWitt (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 26, 2018 Category: Neurology Source Type: research

Apomorphine subcutaneous infusion in patients with Parkinson's disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial
This study is registered with ClinicalTrials.gov (NCT02006121).FindingsBetween March 3, 2014, and March 1, 2016, 128 patients were screened for eligibility and 107 were randomly assigned, of whom 106 were included in the full analysis set (n=53 in both groups). Apomorphine infusion (mean final dose 4·68 mg/h [SD 1·50]) significantly reduced off time compared with placebo (−2·47 h per day [SD 3·70] in the apomorphine group vs −0·58 h per day [2·80] in the placebo group; difference −1·89 h per day, 95% CI −3·16 to −0·62; p=0·0...
Source: The Lancet Neurology - July 26, 2018 Category: Neurology Source Type: research

Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study
Publication date: Available online 24 July 2018Source: The Lancet NeurologyAuthor(s): Jeffrey J Bazarian, Peter Biberthaler, Robert D Welch, Lawrence M Lewis, Pal Barzo, Viktoria Bogner-Flatz, P Gunnar Brolinson, Andras Büki, James Y Chen, Robert H Christenson, Dallas Hack, J Stephen Huff, Sandeep Johar, J Dedrick Jordan, Bernd A Leidel, Tobias Lindner, Elizabeth Ludington, David O Okonkwo, Joseph Ornato, W Frank PeacockSummaryBackgroundMore than 50 million people worldwide sustain a traumatic brain injury (TBI) annually. Detection of intracranial injuries relies on head CT, which is overused and resource intensive. B...
Source: The Lancet Neurology - July 25, 2018 Category: Neurology Source Type: research

ALERT-TBI study on biomarkers for TBI: has science suffered?
Publication date: Available online 24 July 2018Source: The Lancet NeurologyAuthor(s): Andrew I R Maas, Hester F Lingsma (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 25, 2018 Category: Neurology Source Type: research

Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis
Publication date: Available online 23 July 2018Source: The Lancet NeurologyAuthor(s): Thaís Armangue, Marianna Spatola, Alexandru Vlagea, Simone Mattozzi, Marc Cárceles-Cordon, Eloy Martinez-Heras, Sara Llufriu, Jordi Muchart, María Elena Erro, Laura Abraira, German Moris, Luis Monros-Giménez, Íñigo Corral-Corral, Carmen Montejo, Manuel Toledo, Luis Bataller, Gabriela Secondi, Helena Ariño, Eugenia Martínez-Hernández, Manel JuanSummaryBackgroundHerpes simplex encephalitis can trigger autoimmune encephalitis that leads to neurological worsening. We aimed to asse...
Source: The Lancet Neurology - July 24, 2018 Category: Neurology Source Type: research

Autoimmune encephalitis after herpes simplex encephalitis: insights into pathogenesis
Publication date: Available online 23 July 2018Source: The Lancet NeurologyAuthor(s): Jeffrey M Gelfand (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 24, 2018 Category: Neurology Source Type: research

Clinical presentation, management, and pathophysiology of neuropathic itch
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Martin Steinhoff, Martin Schmelz, Imre Lőrinc Szabó, Anne Louise OaklanderSummaryUnlike conventional itch, neuropathic itch develops in normal skin from excess peripheral firing or dampened central inhibition of itch pathway neurons. Neuropathic itch is a symptom of the same central and peripheral nervous system disorders that cause neuropathic pain, such as sensory polyneuropathy, radiculopathy, herpes zoster, stroke, or multiple sclerosis, and lesion location affects symptoms more than aetiology. The causes of neuropathic itch...
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

Response to the growing dementia burden must be faster
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): The Lancet Neurology (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

Expanding role of GABAA receptors in generalised epilepsies
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Heather C Mefford (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

Integrating multiple sclerosis guidelines into practice
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Gabrielle Macaron, Jeffrey A Cohen (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

Thank you to our peer reviewers in 2017
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Caitlin Aspinall (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

Corrections
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Patrick May, Simon Girard, Merle Harrer, Dheeraj R Bobbili, Julian Schubert, Stefan Wolking, Felicitas Becker, Pamela Lachance-Touchette, Caroline Meloche, Micheline Gravel, Cristina E Niturad, Julia Knaus, Carolien De Kovel, Mohamad Toliat, Anne Polvi, Michele Iacomino, Rosa Guerrero-López, Stéphanie Baulac, Carla Marini, Holger ThieleSummaryBackgroundGenetic generalised epilepsy is the most common type of inherited epilepsy. Despite a high concordance rate of 80% in monozygotic twins, the genetic background is still poor...
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

Top research priorities for stroke genetics
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Daniel Woo, Christopher D Anderson, Jane Maguire, Myriam Fornage, Jin-Moo Lee, Sudha Seshadri, Hugh S Markus, Jennifer J Majersik, Jordi Jimenez-Conde, Katherine Crawford, Arne G Lindgren, Stephanie Debette (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

The communicable nature of non-communicable diseases
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Lee H Schwamm (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

Jo Barnes
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

Neurology through the humanities
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Farhat Husain, Jerry Vanatta (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Susana Carmona, Kathleen Zahs, Elizabeth Wu, Kelly Dakin, Jose Bras, Rita GuerreiroSummaryAlzheimer's disease is a genetically complex disorder; rare variants in the triggering receptor expressed on myeloid cells 2 (TREM2) gene have been shown to as much as triple an individual's risk of developing Alzheimer's disease. TREM2 is a transmembrane receptor expressed in cells of the myeloid lineage, and its association with Alzheimer's disease supports the involvement of immune and inflammatory pathways in the cause of the disease, rather th...
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

The life expectancy of Stephen Hawking, according to the ENCALS model
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Henk-Jan Westeneng, Ammar Al-Chalabi, Orla Hardiman, Thomas PA Debray, Leonard H van den Berg (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

The evolution of universally accessible building design
Publication date: Available online 11 July 2018Source: The Lancet NeurologyAuthor(s): Colin Martin (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 12, 2018 Category: Neurology Source Type: research

Bruce Ransom: energy, inspiration, and curiosity
Publication date: Available online 11 July 2018Source: The Lancet NeurologyAuthor(s): Tony Kirby (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 12, 2018 Category: Neurology Source Type: research

Phillip Low: the autonomic expert
Publication date: Available online 18 August 2017Source: The Lancet NeurologyAuthor(s): Jules Morgan (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

Vladimir Mikhailovich Bekhterev
Publication date: Available online 27 September 2017Source: The Lancet NeurologyAuthor(s): Elena Bozhkova (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

Being Andrew Lees
Publication date: Available online 12 January 2018Source: The Lancet NeurologyAuthor(s): Adrian Burton (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

Cécile Vogt
Publication date: Available online 12 January 2018Source: The Lancet NeurologyAuthor(s): Rebecca Akkermans (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

How far away the cornfield. Dennis Spencer's journey
Publication date: Available online 23 March 2018Source: The Lancet NeurologyAuthor(s): Adrian Burton (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

Ingrid Scheffer: improving patient outcomes in epilepsy
Publication date: Available online 5 April 2018Source: The Lancet NeurologyAuthor(s): Tony Kirby (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

James Ironside: modest manner, mighty impact
Publication date: Available online 5 April 2018Source: The Lancet NeurologyAuthor(s): Ruth Williams (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

There is no fooling dementia
Publication date: Available online 16 April 2018Source: The Lancet NeurologyAuthor(s): Jules Morgan (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

Augusta Dejerine-Klumpke
Publication date: Available online 23 April 2018Source: The Lancet NeurologyAuthor(s): Vijay Shankar Balakrishnan (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

The Clive Ballard energy equation
Publication date: Available online 25 April 2018Source: The Lancet NeurologyAuthor(s): Adrian Burton (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

Out of the ring: boxing and long-term brain damage
Publication date: Available online 4 May 2018Source: The Lancet NeurologyAuthor(s): Jules Morgan (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

William Alexander Hammond
Publication date: Available online 8 May 2018Source: The Lancet NeurologyAuthor(s): Ray Cavanaugh (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

Experiencing life in an asylum
Publication date: Available online 22 May 2018Source: The Lancet NeurologyAuthor(s): Elena Bozhkova (Source: The Lancet Neurology)
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research