Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence?
Publication date: Available online 1 April 2020Source: The Lancet NeurologyAuthor(s): Hua Zhao, Dingding Shen, Haiyan Zhou, Jun Liu, Sheng Chen (Source: The Lancet Neurology)
Source: The Lancet Neurology - April 2, 2020 Category: Neurology Source Type: research

A radical proposal for the EU budget: brain health
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): The Lancet Neurology (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

Old and new breakthroughs in neuromyelitis optica
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): Hans-Peter Hartung, Orhan Aktas (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

Rethinking multiple sclerosis treatment strategies
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): Massimo Filippi, Maria A Rocca (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

Nusinersen in adults with spinal muscular atrophy: new challenges
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): Eugenio Mercuri, Valeria Sansone (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

New paradigms of clinical trial design for genetic prion diseases
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): Adriano Aguzzi, Karl Frontzek (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

Safety of adjunctive treatment with cenobamate in patients with uncontrolled focal seizures
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): Basanagoud Mudigoudar, James Wheless (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

Safety of adjunctive treatment with cenobamate in patients with uncontrolled focal seizures – Authors' reply
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): Gregory L Krauss, Pavel Klein, Christian Brandt, Sang Kun Lee, Ivan Milanov, Maja Milovanovic, Bernhard J Steinhoff, Marc Kamin (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

Correction to Lancet Neurol 2020; 19: 234–46
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

Correction to Lancet Neurol 2020; 19: 247–54
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

Safety and efficacy of rituximab in neuromyelitis optica spectrum disorders (RIN-1 study): a multicentre, randomised, double-blind, placebo-controlled trial
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): Masayuki Tahara, Tomoko Oeda, Kazumasa Okada, Takao Kiriyama, Kazuhide Ochi, Hirofumi Maruyama, Hikoaki Fukaura, Kyoichi Nomura, Yuko Shimizu, Masahiro Mori, Ichiro Nakashima, Tatsuro Misu, Atsushi Umemura, Kenji Yamamoto, Hideyuki Sawada (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

Timing of high-efficacy therapy for multiple sclerosis: a retrospective observational cohort study
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): Anna He, Bernd Merkel, James William L Brown, Lana Zhovits Ryerson, Ilya Kister, Charles B Malpas, Sifat Sharmin, Dana Horakova, Eva Kubala Havrdova, Tim Spelman, Guillermo Izquierdo, Sara Eichau, Maria Trojano, Alessandra Lugaresi, Raymond Hupperts, Patrizia Sola, Diana Ferraro, Jan Lycke, Francois Grand'Maison, Alexandre Prat (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

Nusinersen in adults with 5q spinal muscular atrophy: a non-interventional, multicentre, observational cohort study
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): Tim Hagenacker, Claudia D Wurster, René Günther, Olivia Schreiber-Katz, Alma Osmanovic, Susanne Petri, Markus Weiler, Andreas Ziegler, Josua Kuttler, Jan C Koch, Ilka Schneider, Gilbert Wunderlich, Natalie Schloss, Helmar C Lehmann, Isabell Cordts, Marcus Deschauer, Paul Lingor, Christoph Kamm, Benjamin Stolte, Lena Pietruck (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

Towards a treatment for genetic prion disease: trials and biomarkers
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): Sonia M Vallabh, Eric Vallabh Minikel, Stuart L Schreiber, Eric S Lander (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

T cells in Alzheimer's disease: space invaders
Publication date: April 2020Source: The Lancet Neurology, Volume 19, Issue 4Author(s): Róisín M McManus, Michael T Heneka (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 19, 2020 Category: Neurology Source Type: research

Social media could address the gender gap in neurosurgery
Publication date: Available online 17 March 2020Source: The Lancet NeurologyAuthor(s): Emma Jane Norton, Soham Bandyopadhyay, Jigishaa Moudgil-Joshi, The Neurology and Neurosurgery Interest Group (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 18, 2020 Category: Neurology Source Type: research

Initiation of pharmacological therapy in Parkinson's disease: when, why, and how
Publication date: Available online 12 March 2020Source: The Lancet NeurologyAuthor(s): Rob M A de Bie, Carl E Clarke, Alberto J Espay, Susan H Fox, Anthony E Lang (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 14, 2020 Category: Neurology Source Type: research

A pragmatic, personalised approach to treatment initiation in Parkinson's disease
Publication date: Available online 12 March 2020Source: The Lancet NeurologyAuthor(s): Anthony Schapira (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 14, 2020 Category: Neurology Source Type: research

Parkinson's disease in the MENASA countries
Publication date: Available online 10 March 2020Source: The Lancet NeurologyAuthor(s): Hanan Khalil, Lana Chahine, Junaid Siddiqui, Zakiyah Aldaajani, Jawad A Bajwa (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 11, 2020 Category: Neurology Source Type: research

Evidence-based support for autistic people across the lifespan: maximising potential, minimising barriers, and optimising the person–environment fit
Publication date: Available online 3 March 2020Source: The Lancet NeurologyAuthor(s): Meng-Chuan Lai, Evdokia Anagnostou, Max Wiznitzer, Carrie Allison, Simon Baron-Cohen (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 5, 2020 Category: Neurology Source Type: research

Setting the research agenda to secure the wellbeing of autistic people
Publication date: Available online 3 March 2020Source: The Lancet NeurologyAuthor(s): Kristelle Hudry, Elizabeth Pellicano, Mirko Uljarević, Andrew J O Whitehouse (Source: The Lancet Neurology)
Source: The Lancet Neurology - March 5, 2020 Category: Neurology Source Type: research

30 years of second-generation antiseizure medications: impact and future perspectives
Publication date: Available online 25 February 2020Source: The Lancet NeurologyAuthor(s): Emilio Perucca, Martin J Brodie, Patrick Kwan, Torbjörn Tomson (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 27, 2020 Category: Neurology Source Type: research

Have new antiseizure medications improved clinical care over the past 30 years?
Publication date: Available online 25 February 2020Source: The Lancet NeurologyAuthor(s): Jacqueline A French, Robert T Wechsler (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 27, 2020 Category: Neurology Source Type: research

Leading the way for neuromuscular disorders since 1950
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): The Lancet Neurology (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Issues important to the design of stroke recovery trials
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Steven C Cramer (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

The need for continued care after sponsor closure
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Arne May (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

The need for continued care after sponsor closure – Authors' reply
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Peter J Goadsby, Ali R Rezai, David W Dodick (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Health-care disparities for people with multiple sclerosis
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Joanna Laurson-Doube, Nick Rijke, Kathleen Costello, Jennifer McDonell, Gavin Giovannoni, Brenda Banwell, Peer Baneke (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Osmotherapy in traumatic brain injury
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Matthew J Rowland, Tonny Veenith, Peter J Hutchinson, Gavin D Perkins, SOS Trial Investigators (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Correction to Lancet Neurol 2020; 19: 38–48
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Correction to Lancet Neurol 2020; 19: 247–54
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Hugues Chabriat, Claudio L Bassetti, Ute Marx, Marie-Laure Audoli-Inthavong, Aurore Sors, Estelle Lambert, Marine Wattez, Dirk M Hermann, Katharina ALTHAUS, Sergi AMARO, Hee-Joon BAE, Zbigniew BAK, Leonardo BARBARINI, Pietro BASSI, Rodrigo BAZAN, Daniel BERECZKI, Tomasz BERKOWICZ, Joerg BERROUSCHOT, Dylan BLACQUIERE, Waldemar BROLASummaryBackgroundS44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of the peri-infarct cortex. S44819 improved stroke recovery in rodents and increased cortical exc...
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Patient-reported outcome measures: the need for new and reliable tools
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Ankur Khajuria (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Long-term unsupervised mobility assessment in movement disorders
Publication date: Available online 11 February 2020Source: The Lancet NeurologyAuthor(s): Elke Warmerdam, Jeffrey M Hausdorff, Arash Atrsaei, Yuhan Zhou, Anat Mirelman, Kamiar Aminian, Alberto J Espay, Clint Hansen, Luc J W Evers, Andreas Keller, Claudine Lamoth, Andrea Pilotto, Lynn Rochester, Gerhard Schmidt, Bastiaan R Bloem, Walter MaetzlerSummaryMobile health technologies (wearable, portable, body-fixed sensors, or domestic-integrated devices) that quantify mobility in unsupervised, daily living environments are emerging as complementary clinical assessments. Data collected in these ecologically valid, patient-relevan...
Source: The Lancet Neurology - February 12, 2020 Category: Neurology Source Type: research

Wearable-based mobility monitoring: the long road ahead
Publication date: Available online 11 February 2020Source: The Lancet NeurologyAuthor(s): Alfonso Fasano, Martina Mancini (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 12, 2020 Category: Neurology Source Type: research

Advances in oral immunomodulating therapies in relapsing multiple sclerosis
Publication date: Available online 11 February 2020Source: The Lancet NeurologyAuthor(s): Tobias Derfuss, Matthias Mehling, Athina Papadopoulou, Amit Bar-Or, Jeffrey A Cohen, Ludwig KapposSummaryBackgroundOral treatment options for disease-modifying therapy in relapsing multiple sclerosis have substantially increased over the past decade with four approved oral compounds now available: fingolimod, dimethyl fumarate, teriflunomide, and cladribine. Although these immunomodulating therapies are all orally administered, and thus convenient for patients, they have different modes of action. These distinct mechanisms of action a...
Source: The Lancet Neurology - February 12, 2020 Category: Neurology Source Type: research

Associations of paediatric demyelinating and encephalitic syndromes with myelin oligodendrocyte glycoprotein antibodies: a multicentre observational study
In this study, we aimed to determine the frequency and distribution of paediatric demyelinating and encephalitic syndromes with MOG antibodies, their response to treatment, and the phenotypes associated with poor prognosis.MethodsIn this prospective observational study, children with demyelinating syndromes and with encephalitis other than acute disseminated encephalomyelitis (ADEM) recruited from 40 secondary and tertiary centres in Spain were investigated for MOG antibodies. All MOG antibody-positive cases were included in our study, which assessed syndromes, treatment and response to treatment (ie, number of relapses), ...
Source: The Lancet Neurology - February 11, 2020 Category: Neurology Source Type: research

Breaking boundaries between demyelinating disorders and autoimmune encephalitis
Publication date: Available online 10 February 2020Source: The Lancet NeurologyAuthor(s): Romain Marignier (Source: The Lancet Neurology)
Source: The Lancet Neurology - February 11, 2020 Category: Neurology Source Type: research

Advances and challenges in stroke rehabilitation
Publication date: Available online 28 January 2020Source: The Lancet NeurologyAuthor(s): Cathy M Stinear, Catherine E Lang, Steven Zeiler, Winston D ByblowSummaryStroke remains a leading cause of adult disability and the demand for stroke rehabilitation services is growing. Substantial advances are yet to be made in stroke rehabilitation practice to meet this demand and improve patient outcomes relative to current care. Several large intervention trials targeting motor recovery report that participants' motor performance improved, but to a similar extent for both the intervention and control groups in most trials. These ne...
Source: The Lancet Neurology - January 30, 2020 Category: Neurology Source Type: research

β-adrenoreceptors and the risk of Parkinson's disease
Publication date: Available online 27 January 2020Source: The Lancet NeurologyAuthor(s): Franziska Hopfner, Günter U Höglinger, Gregor Kuhlenbäumer, Anton Pottegård, Mette Wod, Kaare Christensen, Caroline M Tanner, Günther DeuschlSummaryBackgroundβ-adrenoceptors are widely expressed in different human organs, mediate important body functions and are targeted by medications for various diseases (such as coronary heart disease and heart attack) and many β-adrenoceptor acting drugs are listed on the WHO Model List of Essential Medicines. β-adrenoceptor antagonists are used by billions ...
Source: The Lancet Neurology - January 28, 2020 Category: Neurology Source Type: research

Interpretation of risk loci from genome-wide association studies of Alzheimer's disease
Publication date: Available online 24 January 2020Source: The Lancet NeurologyAuthor(s): Shea J Andrews, Brian Fulton-Howard, Alison GoateSummaryBackgroundAlzheimer's disease is a debilitating and highly heritable neurological condition. As such, genetic studies have sought to understand the genetic architecture of Alzheimer's disease since the 1990s, with successively larger genome-wide association studies (GWAS) and meta-analyses. These studies started with a small sample size of 1086 individuals in 2007, which was able to identify only the APOE locus. In 2013, the International Genomics of Alzheimer's Project (IGAP) did...
Source: The Lancet Neurology - January 25, 2020 Category: Neurology Source Type: research

Feast or famine in multiple sclerosis therapeutics
Publication date: Available online 22 January 2020Source: The Lancet NeurologyAuthor(s): Robert J Fox (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 24, 2020 Category: Neurology Source Type: research

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial
Publication date: Available online 22 January 2020Source: The Lancet NeurologyAuthor(s): Jeremy Chataway, Floriana De Angelis, Peter Connick, Richard A Parker, Domenico Plantone, Anisha Doshi, Nevin John, Jonathan Stutters, David MacManus, Ferran Prados Carrasco, Frederik Barkhof, Sebastien Ourselin, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Gavin Giovannoni, Claudia Angela Gandini Wheeler-Kingshott, Clive Hawkins, Basil SharrackSummaryBackgroundNeurodegeneration is the pathological substrate that causes major disability in secondary progressive multiple sclerosis. A synthesis of preclinical and clinical re...
Source: The Lancet Neurology - January 24, 2020 Category: Neurology Source Type: research

Publication records versus scientific progress
Publication date: February 2020Source: The Lancet Neurology, Volume 19, Issue 2Author(s): The Lancet Neurology (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 22, 2020 Category: Neurology Source Type: research

Research participation for patients with spinal cord injury
Publication date: February 2020Source: The Lancet Neurology, Volume 19, Issue 2Author(s): Annemie Heselmans (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 22, 2020 Category: Neurology Source Type: research

Correction to Lancet Neurol 2018; 17: 597–608
Publication date: February 2020Source: The Lancet Neurology, Volume 19, Issue 2Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 22, 2020 Category: Neurology Source Type: research

Correction to Lancet Neurol 2019; 18: 1078–79
Publication date: February 2020Source: The Lancet Neurology, Volume 19, Issue 2Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 22, 2020 Category: Neurology Source Type: research

Correction to Lancet Neurol 2020; 19: 106–08
Publication date: February 2020Source: The Lancet Neurology, Volume 19, Issue 2Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 22, 2020 Category: Neurology Source Type: research

Correction to Lancet Neurol 2020; 19: 145–56
Publication date: February 2020Source: The Lancet Neurology, Volume 19, Issue 2Author(s): (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 22, 2020 Category: Neurology Source Type: research

Subjective cognitive decline: what is it good for?
Publication date: Available online 17 January 2020Source: The Lancet NeurologyAuthor(s): Robert Howard (Source: The Lancet Neurology)
Source: The Lancet Neurology - January 19, 2020 Category: Neurology Source Type: research