Modified Suturing Techniques in Carotid Endarterectomy for Reducing the Cerebral Ischemic Time.
Conclusion: Two modified arteriotomy suture techniques could reduce perioperative ischemic complications by reducing the cerebral ischemic time. PMID: 32906227 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - September 12, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Prediction of Risk Factors after Spine Surgery in Patients Aged > 75 Years Using the Modified Frailty Index.
Conclusion: The mFI can successfully predict postoperative morbidity and mortality in patients aged ≥75 years undergoing spine surgery. The mFI improves perioperative risk stratification that provides important information to assist in the preoperative counselling of patients and their families. PMID: 32898965 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - September 11, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Feasibility of Posterior Cervical Foraminotomy for Adjacent Segmental Disease after Anterior Cervical Fusion.
Authors: Kim HJ, Kang MS, Lee SH, Park CH, Chung SW, Shin YH, Lee SY, Park ES Abstract Objective: The aim of this study is to evaluate the feasibility of posterior cervical foraminotomy (PCF) for adjacent segmental disease (ASD) after anterior cervical fusion (ACF). As ACF is accepted as the standard treatment for cervical spondylosis, many studies have been conducted to evaluate the efficacy of various surgical techniques to overcome symptomatic ASD after the previous surgery. Herein, PCF was performed for the treatment of symptomatic ASD and the feasibility of the surgery was evaluated. Methods: Forty nine pa...
Source: Journal of Korean Neurosurgical Society - September 11, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Intraoperative Neurophysiology Monitoring for Spinal Dysraphism.
Authors: Kim K Abstract Spinal dysraphism often causes neurological impairment from direct involvement of lesions or from cord tethering. The conus medullaris and lumbosacral roots are most vulnerable. Surgical intervention such as untethering surgery is indicated to minimize or prevent further neurological deficits. Because untethering surgery itself imposes risk of neural injury, intraoperative neurophysiological monitoring (IONM) is indicated to help surgeons to be guided during surgery and to improve functional outcome. Monitoring of electromyography (EMG), motor evoked potential, and bulbocavernosus reflex (BC...
Source: Journal of Korean Neurosurgical Society - September 11, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Impact of Time Interval between Index Event and Stenting on Periprocedural Risk in Patients with Symptomatic Carotid Stenosis.
CONCLUSION: This study showed that as stenting was delayed, the periprocedural risk for clinical events decreased. The clinical event risk was high only in stenting within 7 days and comparable with that for asymptomatic stenosis in stenting after 7 days from index event, although the radiological event risk was not affected by stenting timing. Therefore, our results suggest that delayed stenting after 7 days from symptom onset is a safe strategy for symptomatic stenosis. PMID: 32883055 [PubMed] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - September 6, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Influence of Triggering Events on the Occurrence of Spontaneous Intracranial Hemorrhage : Comparison of Non-Lesional Spontaneous Intraparenchymal Hemorrhage and Aneurysmal Subarachnoid Hemorrhage.
CONCLUSION: Specific physical activity dose no affect the incidence of nIPH and aSAH. The relationship between the occurrence of intracranial hemorrhage and triggering events is higher in aSAH than nIPH. PMID: 32883056 [PubMed] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - September 6, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

What Is the Ideal Entry Point for Transforaminal Endoscopic Lumbar Discectomy?
CONCLUSION: We reviewed the risk of the extreme lateral approach by analyzing rates of retroperitoneal and visceral violations during well-known methods of approach. We suggested an ideal entry point at each level of the lumbar spine and found a positive correlation between the distance of the entry point to the midline and patient characteristics such as BMI, weight, and the depth of the posterior vertebral line from the skin. PMID: 32883057 [PubMed] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - September 6, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Relationship between Increased Intracranial Pressure and Mastoid Effusion.
CONCLUSION: While multiple factors affect ME, this study demonstrates that ICP and ME are probably related. Further studies are needed to determine the mechanistic relationship between ICP and middle ear pressure. PMID: 32883058 [PubMed] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - September 6, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Missed Skeletal Trauma Detected by Whole Body Bone Scan in Patients with Traumatic Brain Injury.
CONCLUSION: WBBS is a potential diagnostic tool in understanding the skeletal conditions of patients with head injuries which may be undetected during the initial assessment. PMID: 32883059 [PubMed] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - September 6, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Intracranial Metaplastic Meningioma : Clinical and Radiological Characteristics of 11 Cases.
CONCLUSION: We investigated a rare metaplastic meningioma subtype based on our 15-year surgical experience with meningiomas. Further investigation will be necessary for the clear clarification of tumor nature of this rare tumor. PMID: 32883060 [PubMed] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - September 6, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Effect of Podophyllotoxin Conjugated Stearic Acid Grafted Chitosan Oligosaccharide Micelle on Human Glioma Cells.
Authors: Wang GH, Shen HP, Huang X, Jiang XH, Jin CS, Chu ZM Abstract Objective: To study the physiochemical characteristics of podophyllotoxin (PPT) conjugated stearic acid grafted chitosan oligosaccharide micelle (PPT-CSO-SA), and evaluate the ability of the potential antineoplastic effects against glioma cells. Methods: PPT-CSO-SA was prepared by a dialysis method. The quality of PPT-CSO-SA including micellar size, zeta potential, drug encapsulation efficiency and drug release profiles was evaluated. Glioma cells were cultured and treated with PPT and PPT-CSO-SA. The ability of glioma cells to uptake PPT-CSO...
Source: Journal of Korean Neurosurgical Society - August 20, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Extent of Hyperostotic Bone Resection in Convexity Meningioma to Achieve Pathologically Free Margins.
Conclusion: Removal of the gross epicentre of hyperostotic bone with the surrounding 2 cm is adequate to ensure radical excision and free bone margins in grade I and II meningiomas. Hyperintense signal change in MRI T2 weighted images, even beyond visible hypersototic areas, doesn't necessarily represent tumour invasion. PMID: 32750757 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - August 13, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Outcomes of Stent-Assisted Coiling Using the Neuroform Atlas Stent in Unruptured Wide-Necked Intracranial Aneurysms.
Conclusion: The Neuroform Atlas showed a high rate of technical success. Good clinical and radiographic outcomes in early follow-up suggests that the device is feasible and safe. SAC of aneurysms on the middle cerebral artery or anterior communicating artery may require more attention to prevent possible procedure-related complications. PMID: 32759624 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - August 13, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Early versus Delayed Surgery for Spinal Epidural Abscess : Clinical Outcome and Health-Related Quality of Life.
Conclusion: Our data on both clinical outcome and QOL provide evidence for early surgery within 12 hours after admission in patients with SEA. PMID: 32759625 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - August 13, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Is the Agricultural Work a Risk Factor for Koreans Elderly Spinal Sagittal Imbalance?
Conclusion: The farmer group had more sagittal imbalance and back pain in proportion to the working hours even though the muscle and bone factors and general laboratory condition were not significantly different between the two groups. These results supported that the long hours spent in the crouched posture while performing agricultural work were a risk factor for severe sagittal imbalance. PMID: 32759626 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - August 13, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Effectiveness and Technical Considerations of Solitaire Platinum 4 ×40 mm Stent Retriever in Mechanical Thrombectomy with Solumbra Technique.
Conclusion: Our study demonstrated the usefulness of the Solitaire Platinum 4×40 mm stent retriever, which led to higher firstpass reperfusion and complete reperfusion rates than the Solitaire FR 4×20 mm stent or the Solitaire Platinum 4×20 mm stent, especially in Solumbra technique thrombectomy. PMID: 32759627 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - August 13, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Current Status of Neurosurgical and Neurointensive Care Units in Korea : A Brief Report on Nationwide Survey Results.
CONCLUSION: We hope the results of this survey will guide successful implementation of neurointensivist systems across Korea. PMID: 32664714 [PubMed] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - July 17, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Novel Noncrossing Y-Stent Technique Using Tapered Proximal End of a Solitaire AB Stent for Coil Embolization of Wide-Neck Bifurcation Aneurysms.
Authors: Kwon HJ, Lim JW, Byoun HS, Koh HS Abstract The crossing Y-stent method is one of the indispensable techniques to achieve sufficient neck coverage during coil embolization of bifurcation aneurysms with a wide neck and/or branch incorporation. However, the inevitable hourglass-like expansion of the second stent at the crossing point can result in insufficient vessel wall apposition, reduced aneurysm neck coverage, delayed endothelialization, and subsequent higher risks of acute or delayed thrombosis. It also interferes with engagement of the microcatheter into the aneurysm after stent installation. We expect...
Source: Journal of Korean Neurosurgical Society - July 11, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Change of Pyogenic and Tuberculous Spondylitis between 2007 and 2016 Year : A Nationwide Study.
Authors: Kim YJ, Hong JB, Kim YS, Yi J, Choi JM, Sohn S Abstract Objective: We attempted to compare the incidence of pyogenic spondylitis (PS) and tuberculous spondylitis (TS) between 2007 and 2016. Furthermore, we investigated the patients who underwent surgery in 2016 compared to that in 2007. Methods: We used a nationwide database managed by the Korean National Health Insurance Service (NHIS) in 2007 and 2016. Total 9655 patients with a newly diagnosis of PS or TS were enrolled in PS or TS group. Among them, 1721 patients underwent either fusion or decompression surgery. We analyzed demographic distribution ...
Source: Journal of Korean Neurosurgical Society - July 7, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Carpal Tunnel Syndrome Caused by Lipofibromatous Hamartoma of the Median Nerve.
Authors: Roh YT, Song SW, Jeong C, Kang Y, Park IJ Abstract Lipofibromatous hamartoma (LFH) is a rare tumor of the peripheral nerves, which usually involves the median nerve. The authors reported on two rare cases of carpal tunnel syndrome due to LFH of the median nerve. A 49-year-old female patient complained of the mass and symptoms consistent with LFH. Magnetic resonance imaging (MRI) showed typical LFH findings. The symptoms were successfully ameliorated with carpal tunnel release and external neurolysis. A 37-year-old female patient complained of weakening thumb abduction and the mass where the MRI showed atyp...
Source: Journal of Korean Neurosurgical Society - July 1, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Survival Association and Cell Cycle Effects of B7H3 in Neuroblastoma.
Conclusion: Our results demonstrate that B7H3 expression correlate with clinical survival in NB patients. Preliminary studies suggest that B7H3 may mediate the G1/S transition. PMID: 32580265 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - June 26, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Is the Spinal Instability Neoplastic Score Accurate and Reliable in Predicting Vertebral Compression Fractures for Spinal Metastasis? A Systematic Review and Qualitative Analysis.
Authors: Lee CH, Hong JT, Lee SH, Yi S, Sohn MJ, Kim SH, Chung CK, Korean Spine Oncology Research Society Abstract Spinal metastases can present with varying degrees of mechanical instability. The Spinal Instability Neoplastic Score (SINS) was developed as a tool to assess spinal neoplastic-related instability while helping to guide referrals among oncology specialists. Some previous papers suggested that the SINS was accurate and reliable, while others disagreed with this opinion. We performed a systematic review regarding the SINS to evaluate its accuracy and precision in predicting vertebral compression fracture...
Source: Journal of Korean Neurosurgical Society - June 26, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Surgical Outcomes and Complications Following All Posterior Approach for Spinal Deformity Associated with Neurofibromatosis Type-1.
Conclusion: The surgical correction of patients having spinal deformity associated with NF-1 is challenging, however the radiographic and clinical outcomes are satisfactory. The all posterior approach can be a safe and effective surgical option for patients having dystrophic curves associated with NF-1. PMID: 32512989 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - June 10, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Ventriculoperitoneal Shunt without Hair Shaving Using Absorbable Suture Materials.
Conclusion: Non-shaved shunt surgery may be safe and effective, with no increase of infection rate. We recommend that shunt procedures could be performed without shaving the hair, which may increase patients' satisfaction without increasing infection risk. PMID: 32492983 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - June 6, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Arachnoid Plasty to Prevent and Reduce Chronic Subdural Hematoma after Clipping Surgery for Unruptured Intracranial Aneurysm : A Meta-Analysis.
Conclusion: This meta-analysis indicated that ARP reduced the incidence rates of CSDH following clipping surgery for UIA. If feasible, ARP would be implemented as an additional surgical technique to prevent postoperative CSDH development during surgical clipping of UIA. PMID: 32492984 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - June 6, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

The Dose Dependent Effects of Ruxolitinib on the Invasion and Tumorigenesis in Gliomas Cells via Inhibition of Interferon Gamma-Depended JAK/STAT Signaling Pathway.
Conclusion: Collectively, our results revealed that ruxolitinib may have therapeutic potential in glioblastomas, possibly by JAK/STAT signaling triggered by IFN-α and IFN-γ. PMID: 32492985 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - June 6, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Coronavirus Disease (COVID-19) Outbreak and Its Impact on Spinal Daily Practice : Preliminary Report from a Single (Regional) University Hospital in Republic of Korea.
Conclusion: The outbreak of COVID-19 affected our daily practice as OPD and ER visits reduced but did not affect the number of surgeries. We believe that this report will be informative to spinal specialists worldwide fighting the COVID-19 pandemic. PMID: 32455517 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - May 28, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Percutaneous Sacroplasty : Effectiveness and Long-Term Outcome Predictors.
Conclusion: PSP was effective for sacral insufficiency fractures and showed good long-term outcomes. Combined compression fractures in the thoracolumbar spine and degenerative lumbar pathologies could be possible poor outcome predictors. PMID: 32455518 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - May 28, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Influence of Antithrombotic Medication on the Risk of Chronic Subdural Hematoma Recurrence after Burr-Hole Surgery.
Conclusion: The present study found that preoperative antithrombotic medication was independently associated with CSDH recurrence. PMID: 32455519 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - May 28, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Comparison of Fusion Rate between Demineralized Bone Matrix versus Autograft in Lumbar Fusion : Meta-Analysis.
Authors: Han S, Park B, Lim JW, Youm JY, Choi SW, Kim DH, Ahn DK Abstract The demineralized bone matrix (DBM) as the bone graft material to increase the fusion rate was widely used in spinal fusion. The current study aimed to compare the fusion rate of DBM to the fusion rate of autograft in lumbar spine fusion via meta-analysis of published literature. After systematic search, comparative studies were selected according to eligibility criteria. Checklist (risk of bias assessment tool for non-randomized study) was used to evaluate the risk of bias of the included nonrandomized controlled studies. The corresponding 9...
Source: Journal of Korean Neurosurgical Society - May 28, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

The Influence of Comorbidities on Reoperations Following Primary Surgery of Lumbar Degenerative Diseases : A Nationwide Population-Based Retrospective Cohort Study from 2009-2016.
Authors: Park HK, Park SY, Lee PH, Park HR, Park SQ, Cho SJ, Chang JC Abstract Objective: Spinal degeneration is a progressive disease, worsening over time. Lumbar degenerative disease (LDD) is a major spinal disease in elderly patients. Surgical treatment is considered for medically intractable patients with LDD and reoperation after primary surgery is not uncommon. The surgical outcome is occasionally unpredictable because of comorbidities. In the present study, the relationship between comorbidities and the incidence of reoperation for LDD over time was determined. Methods: The claims data of the health insu...
Source: Journal of Korean Neurosurgical Society - May 22, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Radiosurgery for Cerebral Arteriovenous Malformation (AVM) : Current Treatment Strategy and Radiosurgical Technique for Large Cerebral AVM : Review Article.
Authors: Byun J, Kwon DH, Lee DH, Park W, Park JC, Ahn JS Abstract Arteriovenous malformations (AVMs) are congenital anomalies of the cerebrovascular system. AVM harbors 2.2% annual hemorrhage risk in unruptured cases and 4.5% annual hemorrhage risk of previously ruptured cases. Stereotactic radiosurgery (SRS) have been shown excellent treatment outcomes for patients with small- to moderated sized AVM which can be achieved in 80-90% complete obliteration rate with a 2-3 years latency period. The most important factors are associated with obliteration after SRS is the radiation dose to the AVM. In our institutional ...
Source: Journal of Korean Neurosurgical Society - May 21, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

INSPIRE Neuro-Spinal ScaffoldTM : An Implantable Alternative to Stem-Cell Therapy for Endogenous Repair in Spinal Cord Injury.
Authors: Brown N PMID: 32407612 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - May 15, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Surgical Management of Complex Spinal Cord Lipomas : A New Perspective.
Authors: Pang D Abstract This review summarises the classification, anatomy and embryogenesis of complex spinal cord lipomas, and describes in some detail the new technique of total lipoma resection and radical reconstruction of the affected neural placode. Its specific mission is to tackle two main issues surrounding the management of complex dysraphic lipomas : whether total resection confers better long term benefits than partial resection, and whether total resection does better than conservative treatment, i.e., no surgery, for asymptomatic lipomas. Accordingly, the 24 years progression-free survival data of t...
Source: Journal of Korean Neurosurgical Society - May 14, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Urological Evaluation of Tethered Cord Syndrome.
Authors: Park K Abstract To describe how to perform urological evaluation in children with tethered cord syndrome (TCS). Although a common manifestation of TCS is the development of neurogenic bladder in developing children, neurosurgeons often face difficulty in detecting urological problems in patients with TCS. From a urological perspective, diagnosis of TCS in developing children is further complicated due to the differentiation between neurogenic bladder dysfunctions and transient bladder dysfunctions owing to developmental problems. Due to the paucity of evidence regarding evaluation prior to and after unteth...
Source: Journal of Korean Neurosurgical Society - May 14, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Perspectives on Spinal Dysraphism : Past, Present, and Future.
This article recounts the author's personal views and recollections of the history, conception of embryogenetic theories, application of intraoperative electrophysiology, and development of prospective treatment recommendations of several important spinal dysraphic malformations, including limited dorsal myeloschisis, dermal sinus tract, retained medullary cord, terminal myelocystocoele, and complex spinal cord lipomas. PMID: 32392668 [PubMed] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - May 14, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

The Value of Tumor Treating Fields in Glioblastoma.
Authors: Zhang C, Du J, Xu W, Huang H, Gao L Abstract Glioblastoma (GBM) is one of the most common tumors of the central nervous system, which is the most lethal brain cancer. GBM treatment is based primarily on surgical resection, combined with radiotherapy and chemotherapy. Despite the positive treatment, progression free survival and overall survival were not significantly prolonged because GBM almost always recurs. We are always looking forward to some new and effective treatments. In recent years, a novel treatment method called tumor treating fields (TTFields) for cancer treatment has been proposed. TTFields ...
Source: Journal of Korean Neurosurgical Society - May 10, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Is It Possible to Replace Microendoscopic Discectomy with Percutaneous Transforaminal Discectomy for Treatment of Lumbar Disc Herniation? A Meta-Analysis Based on Recurrence and Revision Rate.
Conclusion: PTED has a number of advantages because it is a minimally invasive surgery, but its recurrence and revision rates are higher than MED. Therefore, MED should not be completely replaced by PTED. PMID: 32380585 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - May 10, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

A Preliminary Study of the Association between SOX17 Gene Variants and Intracranial Aneurysms Using Exome Sequencing.
Conclusion: No significant association between SOX17 gene variants and IA were noted in the Korean population. A large-scale exome sequencing study is necessary to investigate any Korean-specific genetic susceptibility to IA. PMID: 32380586 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - May 10, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Single-Stage Reconstruction with Titanium Mesh for Compound Comminuted Depressed Skull Fracture.
Conclusion: Immediate bony fragments replacement and reconstruction with reconstruction titanium mesh for FCCD did not increase infectious sequelae, even though FCCD involved sinus. This suggests that immediate single-stage reconstruction with titanium mesh for FCCD is a suitable surgical option with potential benefits in terms of cost-effectiveness, safety, and cosmetic and psychological outcomes. PMID: 32380587 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - May 10, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Secondary Neurulation Defects-1 : Retained Medullary Cord.
This article reviews the literature to elucidate the pathoembryogenesis, clinical significance and treatment of RMCs. PMID: 32336057 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - April 28, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Spinal Dysraphism in the Last Two Decades : What I Have Seen during the Era of Dynamic Advancement.
Authors: Wang KC Abstract Compared to any other decade, the last two decades have been the most dynamic period in terms of advances in the knowledge on spinal dysraphism. Among the several factors of rapid advancement, such as embryology during secondary neurulation and intraoperative neurophysiological monitoring, there is no doubt that Professor Dachling Pang stood high amidst the period. I review here the last two decades from my personal point of view on what has been achieved in the field of spinal dysraphism, focusing on occult tethered cord syndrome, lumbosacral lipomatous malformation, terminal myelocystoce...
Source: Journal of Korean Neurosurgical Society - April 28, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Terminal Myelocystocele : Pathoembryogenesis and Clinical Features.
Authors: Lee JY, Kim KH, Wang KC Abstract There has been confusion in the classification of terminal myelocystocele (TMCC) due to its diverse morphology and vague pathoembryogenesis. TMCC could be summarized as having the essential features of an elongated caudal spinal cord extruding out of the dorsal extraspinal space that fuses with the subcutaneous fat, which is in the shape of a trumpet-shaped cerebrospinal fluid-filled cyst. The extraspinal portion of the extruded spinal cord is nonfunctional. The morphological features suggest that TMCC is formed during secondary neurulation, specifically the failure of the ...
Source: Journal of Korean Neurosurgical Society - April 28, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Syringomyelia in the Tethered Spinal Cords.
Authors: Lee JY, Kim KH, Wang KC Abstract Cases of syringomyelia associated with spinal dysraphism are distinct from those associated with hindbrain herniation or arachnoiditis in terms of the suspected pathogenetic mechanism. The symptoms of terminal syringomyelia are difficult to differentiate from the symptoms caused by spinal dysraphism. Nonetheless, syringomyelia has important clinical implications, as it is an important sign of cord tethering. The postoperative assessment of syringomyelia should be performed with caution. PMID: 32336060 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - April 28, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Enlargement of Extraspinal Cysts in Spinal Dysraphism : A Reason for Early Untethering.
Authors: Kim KH, Wang KC, Lee JY Abstract Some types of spinal dysraphism can be accompanied by extraspinal cysts, including myelomeningocele, myelocystocele, myelocele, meningocele, limited dorsal myeloschisis, lipomyelomeningocele, and terminal myelocystocele. Each disease is classified according to the developmental mechanism, embryologic process, site of occurrence, or internal structure of the extraspinal cyst. In most cystic spinal dysraphisms except meningocele, part of the spinal cord is attached to the cyst dome. Most open spinal dysraphisms pose a risk of infection and require urgent surgical intervention...
Source: Journal of Korean Neurosurgical Society - April 28, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Preface : Invited Issue Editor Professor Dachling Pang and the Changing Concepts in Spinal Dysraphism during the Last Two Decades.
Authors: Kim CY, Kim SK PMID: 32336062 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - April 28, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Retethering : A Neurosurgical Viewpoint.
This article reviews the literature on the incidence and timing of deterioration, predisposing factors for retethering, clinical manifestations, diagnosis, surgical treatment and its complications, clinical outcomes, prognostic factors after retethering surgery and preventive measures of retethering. Current practice and opinions of Seoul National University Children's Hospital team were added in some parts. The literature shows a wide range of data regarding the incidence, rate and degree of surgical complications and long-term outcomes. The method of prevention is still one of the main topics of this entity. Although alt...
Source: Journal of Korean Neurosurgical Society - April 28, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Junctional Neural Tube Defect.
Authors: Eibach S, Pang D Abstract Junctional neurulation represents the most recent adjunct to the well-known sequential embryological processes of primary and secondary neurulation. While its exact molecular processes, occurring at the end of primary and the beginning of secondary neurulation, are still being actively investigated, its pathological counterpart -junctional neural tube defect (JNTD)- had been described in 2017 based on three patients whose well-formed secondary neural tube, the conus, is widely separated from its corresponding primary neural tube and functionally disconnected from corticospinal con...
Source: Journal of Korean Neurosurgical Society - April 28, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Covered Stenting Is an Effective Option for Traumatic Carotid Pseudoaneurysm with Promising Long-Term Outcome.
Conclusion: Satisfactory procedural and long-term outcomes were obtained, suggesting that covered stenting is an effective option for traumatic carotid pseudoaneurysm. PMID: 32272508 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - April 11, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Dexamethasone Interferes with Autophagy and Affects Cell Survival in Irradiated Malignant Glioma Cells.
Conclusion: Dexamethasone increased cell survival in p53 mutated malignant glioma cells and increased autophagy in PTEN-mutant malignant glioma cell but not in PTEN-wildtype cell. The difference of autophagy response could be mediated though the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling pathway. PMID: 32272509 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - April 11, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research