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Total 964 results found since Jan 2013.

GSE196260 A global transcriptome analysis of human dermal fibroblasts upon knockdown of the circular RNAs circGLIS3 (circBase ID: hsa_circ_0002874)
Contributors : Ning X Land én ; Maria A TomaSeries Type : Expression profiling by arrayOrganism : Homo sapiensIn an RNAseq analysis, we have identified circGLIS3 with high levels acute wound dermis compared to skinThe biological function of circGLIS3 in human dermal fibroblasts during wound repair has not been studied.To study the genes regulated by circGLIS3, we transfected siRNA targeting the diagnostic junctions of circGLIS3 into human dermal fibroblasts to knockdown circGLIS3 expression.We performed a global transcriptome analysis of keratinocytes upon circRNA knockdown using Affymetrix arrays.
Source: GEO: Gene Expression Omnibus - February 6, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Genes, Vol. 14, Pages 398: Suppressors of Break-Induced Replication in Human Cells
Michael Leffak Short tandem DNA repeats are drivers of genome instability. To identify suppressors of break-induced mutagenesis human cells, unbiased genetic screens were conducted using a lentiviral shRNA library. The recipient cells possessed fragile non-B DNA that could induce DNA double-strand breaks (DSBs), integrated at an ectopic chromosomal site adjacent to a thymidine kinase marker gene. Mutagenesis of the thymidine kinase gene rendered cells resistant to the nucleoside analog ganciclovir (GCV). The screen identified genes that have established roles in DNA replication and repair, chromatin modification, re...
Source: Genes - February 3, 2023 Category: Genetics & Stem Cells Authors: Stanley Dean Rider French J. Damewood Rujuta Yashodhan Gadgil David C. Hitch Venicia Alhawach Resha Shrestha Matilyn Shanahan Nathen Zavada Michael Leffak Tags: Article Source Type: research

Multimerin 1 aids in the progression of ovarian cancer possibly via modulation of DNA damage response and repair pathways
Mol Cell Biochem. 2023 Feb 1. doi: 10.1007/s11010-023-04668-5. Online ahead of print.ABSTRACTOvarian cancer is one of the leading causes of deaths among women. Despite advances in the treatment regimes, a high rate of diagnosis in the advanced stage makes it almost an incurable malignancy. Thus, more research efforts are required to identify potential molecular markers for early detection of the disease and therapeutic targets to augment the survival rate of ovarian cancer patients. Previously, in this context, we identified dysregulated expression of multimerin 1 (MMRN1) in ovarian cancer. To elucidate the relationship be...
Source: Molecular and Cellular Biochemistry - February 1, 2023 Category: Biochemistry Authors: Abhinav Saini Vikrant Kumar Anil Kumar Tomar Alpana Sharma Savita Yadav Source Type: research

The linker of nucleoskeleton and cytoskeleton complex is required for X-ray-induced epithelial-mesenchymal transition
This study focused on epithelial-mesenchymal transition (EMT), which contributes to cell migration. Hence, the present study aimed to examine whether sublethal-dose X-irradiation induces EMT and whether LINC complex component SUN1 is involved in low-dose X-ray-induced EMT. This study showed that low-dose (0.5 Gy or 2 Gy) X-irradiation induced EMT in human breast cancer MDA-MB-231 cells. Additionally, X-irradiation increased the expression of SUN1. Therefore, SUN1 was depleted using siRNA. In SUN1-depleted cells, low-dose X-irradiation did not induce EMT. In addition, although the SUN1 splicing variant SUN1_916-depleted cel...
Source: Cell Research - January 25, 2023 Category: Cytology Authors: Hiromasa Imaizumi Kazumasa Minami Miki Hieda Naomasa Narihiro Masahiko Koizumi Source Type: research

Regulatory role of apelin receptor signaling in migration and differentiation of mouse embryonic stem cell-derived mesoderm cells and mesenchymal stem/stromal cells
AbstractMesoderm-derived cells, including bone, muscle, and mesenchymal stem/stromal cells (MSCs), constitute various parts of vertebrate body. Cell therapy with mesoderm specification in vitro may be a promising treatment for diseases affecting organs of mesodermal origin. Repair and regeneration of damaged organs with in vitro generation of mesoderm-derived tissues and MSCs hold a great potential for regenerative therapy. Therefore, understanding the signaling pathways involving mesoderm and mesoderm-derived cellular differentiation is important. Previous findings indicated the importance of Apelin receptor (Aplnr) signa...
Source: Human Cell - January 24, 2023 Category: Cytology Source Type: research

IL-10 enhances cell-to-cell communication in chondrocytes via STAT3 signaling pathway
Cell Signal. 2023 Jan 18:110605. doi: 10.1016/j.cellsig.2023.110605. Online ahead of print.ABSTRACTGap junction intercellular communication (GJIC) allows the transfer of material, message and energy between cells, which influences cell behaviors including cell proliferation, migration, differentiation and apoptosis and determines cell fate. Interleukin-10 (IL-10), a versatile cytokine, attracts more and more attention in the cartilage pathology such as osteoarthritis (OA) due to its potential in anti-inflammatory and wound repair. However, whether IL-10 can mediate GJIC in chondrocytes remains elusive. In the current study...
Source: Cellular Signalling - January 21, 2023 Category: Cytology Authors: Daimo Guo Shiyi Kan Li Zhang Zhixing Niu Mengmeng Duan Yang Liu Xiaohua Pu Mingru Bai Caixia Pi Demao Zhang Chenchen Zhou Jing Xie Source Type: research

Implication of E3 ligase RAD18 in UV-induced mutagenesis in human induced pluripotent stem cells and neuronal progenitor cells
In this study, we employed Sup F assay for the measurement of mutation frequency after UV-C irradiation in induced pluripotent stem cells (iPSCs) as PSC models and neural progenitor cells (NPCs) were derived from iPSCs as differentiated cells. iPSCs and NPCs exhibited a lower mutation frequency compared with the original skin fibroblasts. In RNA-seq analysis, iPSCs and NPCs showed a high expression of RAD18, which is involved in trans-lesion synthesis (TLS) for the emergency tolerance system during the replication process of DNA. Although RAD18 is involved in both error free and error prone TLS in somatic cells, it still r...
Source: Cell Research - January 12, 2023 Category: Cytology Authors: Mikio Shimada Takumi Tokumiya Tomoko Miyake Kaima Tsukada Norie Kanzaki Hiromi Yanagihara Junya Kobayashi Yoshihisa Matsumoto Source Type: research

The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma
Drug Deliv. 2023 Dec;30(1):1-13. doi: 10.1080/10717544.2022.2152911.ABSTRACTTemozolomide (TMZ) is a conventional chemotherapeutic drug for glioma, however, its clinical application and efficacy is severely restricted by its drug resistance properties. O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme, which can repair the DNA damage caused by TMZ. A large number of clinical data show that reducing the expression of MGMT can enhance the chemotherapeutic efficacy of TMZ. Therefore, in order to improve the resistance of glioma to TMZ, an angiopep-2 (A2) modified nanoprodrug of polytemozolomide (P(TMZ)n) tha...
Source: Drug Delivery - December 29, 2022 Category: Drugs & Pharmacology Authors: Haoyue Xu Yongkang Zhang Linfeng Li Yanhong Ren Feng Qian Lansheng Wang Hongwei Ma Ankang Quan Hongmei Liu Rutong Yu Source Type: research

Identify Bcl3 as a novel biomarker shared between severe asthma and lung cancer using next-generation RNA sequencing from archival FFPE tissue biopsies
Conclusion: Our findings indicate a Bcl3 a novel putative biomarker in pathogeneses of both severe asthma and lung cancer.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Salameh, L., Manasa Bhamidimarri, P., Elemam, N., Ali, N., Dairi, Y., Alsharhan, M., Tirmazy, S. H., Hamid, Q., Mahboub, B., Al Heialy, S., Hamoudi, R. Tags: 03.03 - Mechanisms of lung injury and repair Source Type: research

Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-mutant Pancreatic Cancer
Cancer Res. 2022 Nov 8:CAN-22-0391. doi: 10.1158/0008-5472.CAN-22-0391. Online ahead of print.ABSTRACTMutational loss of CDKN2A (encoding p16INK4A) tumor suppressor function is a key genetic step that complements activation of KRAS in promoting the development and malignant growth of pancreatic ductal adenocarcinoma (PDAC). However, pharmacologic restoration of p16INK4A function with inhibitors of CDK4 and CDK6 (CDK4/6) has shown limited clinical efficacy in PDAC. Here, we found that concurrent treatment with both a CDK4/6 inhibitor (CDK4/6i) and an ERK MAPK inhibitor (ERKi) synergistically suppresses the growth of PDAC ce...
Source: Cell Research - November 8, 2022 Category: Cytology Authors: Craig M Goodwin Andrew M Waters Jennifer E Klomp Sehrish Javaid Kirsten L Bryant Clint A Stalnecker Kristina Drizyte-Miller Bjoern Papke Runying Yang Amber M Amparo Irem Ozkan-Dagliyan Elisa Baldelli Valerie Calvert Mariaelena Pierobon Jessica A Sorrentin Source Type: research

PTPRU, a quiescence-induced receptor tyrosine phosphatase negatively regulates osteogenic differentiation of human mesenchymal stem cells
Biochem Biophys Res Commun. 2022 Oct 20;636(Pt 1):41-49. doi: 10.1016/j.bbrc.2022.10.062. Online ahead of print.ABSTRACTBone marrow mesenchymal stem cells (MSCs) are heterogeneous osteo-progenitors that are mainly responsible for bone regeneration and homeostasis. In vivo, a subpopulation of bone marrow MSCs persists in a quiescent state, providing a source of new cells for repair. Previously, we reported that induction of quiescence in hMSCs in vitro skews their differentiation potential in favour of osteogenesis while suppressing adipogenesis. Herein, we uncover a new role for a protein tyrosine phosphatase, receptor typ...
Source: Biochemical and Biophysical Research communications - November 4, 2022 Category: Biochemistry Authors: Mohammad Rumman Jyotsna Dhawan Source Type: research