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Total 964 results found since Jan 2013.
HNRNPC regulates RhoA to induce DNA damage repair and cancer-associated fibroblast activation causing radiation resistance in pancreatic cancer
J Cell Mol Med. 2022 Mar 11. doi: 10.1111/jcmm.17254. Online ahead of print.ABSTRACTPancreatic cancer (PC) is one of the most lethal types of cancer due to its asymptomatic nature in the early stages and consequent late diagnosis. Its mortality rate remains high despite advances in treatment strategies, which include a combination of surgical resection and adjuvant therapy. Although these approaches may have a positive effect on prognosis, the development of chemo- and radioresistance still poses a significant challenge for successful PC treatment. Heterogeneous nuclear ribonucleoprotein C1/C2 (HNRNPC) and RhoA have been i...
Source: Molecular Medicine - March 12, 2022 Category: Molecular Biology Authors: Ning Xia Nannan Yang Qungang Shan Ziyin Wang Xiaoyu Liu Yingjie Chen Jian Lu Wei Huang Zhongmin Wang Source Type: research
RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary neural repair through enhancing vascular autophagy in the thalamus after cerebral cortical infarction
This study aimed to investigate the role of RTN4/Nogo-A in mediating macroautophagy/autophagy and angiogenesis in the thalamus following middle cerebral artery occlusion (MCAO). We assessed secondary neuronal damage, angiogenesis, vascular autophagy, RTN4 and S1PR2 signaling in the thalamus. The effects of RTN4-S1PR2 on vascular autophagy and angiogenesis were evaluated using lentiviral and pharmacological approaches. The results showed that RTN4 and S1PR2 signaling molecules were upregulated in parallel with angiogenesis in the ipsilateral thalamus after MCAO. Knockdown of Rtn4 by siRNA markedly reduced MAP1LC3B-II conver...
Source: Autophagy - March 9, 2022 Category: Cytology Authors: Peiyi Xiao Jinmin Gu Wei Xu Xingyang Niu Jian Zhang Jingjing Li Yicong Chen Zhong Pei Jinsheng Zeng Shihui Xing Source Type: research
Preferential Involvement of BRCA1/BARD1, Not Tip60/Fe65, in DNA Double-Strand Break Repair in Presenilin-1 P117L Alzheimer Models
Neural Plast. 2022 Feb 21;2022:3172861. doi: 10.1155/2022/3172861. eCollection 2022.ABSTRACTRecently, we showed that DNA double-strand breaks (DSBs) are increased by the Aβ 42-amyloid peptide and decreased by all-trans retinoic acid (RA) in SH-SY5Y cells and C57BL/6J mice. The present work was aimed at investigating DSBs in cells and murine models of Alzheimer's disease carrying the preseniline-1 (PS1) P117L mutation. We observed that DSBs could hardly decrease following RA treatment in the mutated cells compared to the wild-type cells. The activation of the amyloidogenic pathway is proposed in the former case as Aβ 42- ...
Source: Neural Plasticity - March 3, 2022 Category: Neurology Authors: Marcella M Authiat Emmanuelle Gruz-Gibelli Julien Colas Estelle Bianchi Marta Garcia-Arauzo Pascale Marin Fran çois R Herrmann Armand Savioz Source Type: research
Pin1-mediated regulation of articular cartilage stem/progenitor cell aging
In this study, we investigated the role of Pin1 in the aging of rat knee joint CSPCs. We isolated CSPCs from rat knee joints and demonstrated that, in long-term in vitro culture, Pin1 protein levels are significantly reduced. At the same time, expression of the senescence-related β-galactosidase and the senescence marker p16INK4A were markedly elevated. In addition, Pin1 overexpression reversed the progression of cellular senescence, as evidenced by the down-regulation of senescence-related β-galactosidase, increased EdU positive cells and diminished levels of p16INK4A. In contrast, Pin1 siRNA incorporation promoted CSPC...
Source: Tissue and Cell - March 1, 2022 Category: Cytology Authors: Xiao Zhang Weiwei Sun Weijie Wu Minhao Chen Tianyi Ji Hua Xu Youhua Wang Source Type: research
