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Procedure: Gastroschisis Repair
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Total 964 results found since Jan 2013.
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
Cell Stem Cell. 2022 Jan 24:S1934-5909(22)00001-7. doi: 10.1016/j.stem.2022.01.001. Online ahead of print.ABSTRACTIdentifying new pathways that regulate mammalian regeneration is challenging due to the paucity of in vivo screening approaches. We employed pooled CRISPR knockout and activation screening in the regenerating liver to evaluate 165 chromatin regulatory proteins. Both screens identified the imitation-SWI chromatin remodeling components Baz2a and Baz2b, not previously implicated in regeneration. In vivo sgRNA, siRNA, and knockout strategies against either paralog confirmed increased regeneration. Distinct BAZ2-spe...
Source: Cell Stem Cell - January 29, 2022 Category: Stem Cells Authors: Yuemeng Jia Lin Li Yu-Hsuan Lin Purva Gopal Shunli Shen Kejin Zhou Xueliang Yu Tripti Sharma Yu Zhang Daniel J Siegwart Joseph M Ready Hao Zhu Source Type: research
AMP-activated protein kinase-dependent nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in senescent human diploid fibroblasts
Aging (Albany NY). 2022 Jan 12;14(undefined). doi: 10.18632/aging.203825. Online ahead of print.ABSTRACTGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme that participates in various cellular events, such as DNA repair and apoptosis. The functional diversity of GAPDH depends on its intracellular localization. Because AMP-activated protein kinase (AMPK) regulates the nuclear translocation of GAPDH in young cells and AMPK activity significantly increases during aging, we investigated whether altered AMPK activity is involved in the nuclear localization of GAPDH in senescent cells. Age-dependent nucl...
Source: Aging - January 12, 2022 Category: Biomedical Science Authors: Jee Young Sohn Hyeok-Jin Kwak Ji Heon Rhim Eui-Ju Yeo Source Type: research
Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination
Biochem Biophys Res Commun. 2021 Dec 30;591:95-101. doi: 10.1016/j.bbrc.2021.12.099. Online ahead of print.ABSTRACTPost-translational modification of proteins by small ubiquitin-like modifier (SUMO) is known to be involved in a variety of cellular events. This modification, called SUMOylation, is carried out by the E1 activating enzyme, the E2 conjugating enzyme, and multiple E3 ligases. Previous studies have demonstrated that the SUMO E3 ligases, protein inhibitors of activated STAT 1 (PIAS1) and 4 (PIAS4), and the SUMO-targeted ubiquitin ligase, RING finger protein 4 (RNF4), play important roles in the repair of DNA doub...
Source: Biochemical and Biophysical Research communications - January 10, 2022 Category: Biochemistry Authors: Moe Moe Han Miyako Hirakawa Motohiro Yamauchi Naoki Matsuda Source Type: research
NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury
In conclusion, 11R-VIVIT administration inhibits IRI-induced NFAT2 activation and prevents AKI-to-CKD progression. Inhibiting NFAT2 may be a promising new therapeutic strategy for preventing renal fibrosis after IR-AKI.PMID:34937917 | DOI:10.1038/s41401-021-00833-y
Source: Acta Pharmacologica Sinica - December 23, 2021 Category: Drugs & Pharmacology Authors: Zhi-Yong Xie Wei Dong Li Zhang Meng-Jie Wang Zhen-Meng Xiao Yu-Hua Zhang Wan-Xin Shi Ying Huang Yan Yang Cui-Li Li Lei Fu Xing-Chen Zhao Rui-Zhao Li Zhi-Lian Li Yuan-Han Chen Zhi-Ming Ye Shuang-Xin Liu Zheng Dong Xin-Ling Liang Source Type: research
HYPK coordinates degradation of polyneddylated proteins by autophagy
Autophagy. 2021 Nov 26:1-22. doi: 10.1080/15548627.2021.1997053. Online ahead of print.ABSTRACTSelective degradation of protein aggregates by macroautophagy/autophagy is an essential homeostatic process of safeguarding cells from the effects of proteotoxicity. Among the ubiquitin-like proteins, NEDD8 conjugation to misfolded proteins is prominent in stress-induced protein aggregates, albeit the function of neddylation in autophagy is unclear. Here, we report that polyneddylation functions as a post-translational modification for autophagic degradation of proteotoxic-stress induced protein aggregates. We also show that HYPK...
Source: Autophagy - November 27, 2021 Category: Cytology Authors: Debasish Kumar Ghosh Akash Ranjan Source Type: research
