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Cancers, Vol. 14, Pages 4123: Recent Trends in Nanomedicine-Based Strategies to Overcome Multidrug Resistance in Tumors
lin Cancer is the leading cause of economic and health burden worldwide. The commonly used approaches for the treatment of cancer are chemotherapy, radiotherapy, and surgery. Chemotherapy frequently results in undesirable side effects, and cancer cells may develop resistance. Combating drug resistance is a challenging task in cancer treatment. Drug resistance may be intrinsic or acquired and can be due to genetic factors, growth factors, the increased efflux of drugs, DNA repair, and the metabolism of xenobiotics. The strategies used to combat drug resistance include the nanomedicine-based targeted delivery of drugs an...
Source: Cancers - August 26, 2022 Category: Cancer & Oncology Authors: Muhammad Muzamil Khan Vladimir P. Torchilin Tags: Review Source Type: research

Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation
Int J Med Sci. 2022 Jul 11;19(8):1254-1264. doi: 10.7150/ijms.70743. eCollection 2022.ABSTRACTMammalian cardiomyocytes (CMs) maintain a low capacity for self-renewal in adulthood, therefore the induction of CMs cycle re-entry is an important approach to promote myocardial repair after injury. Recently, photobiomodulation (PBM) has been used to manipulate physiological activities of various tissues and organs by non-invasive means. Here, we demonstrate that conditioned PBM using light-emitting diodes with a wavelength of 630 nm (LED-Red) was capable of promoting the proliferation of neonatal CMs. Further studies showed that...
Source: International Journal of Medical Sciences - August 5, 2022 Category: Biomedical Science Authors: Xinlu Gao Hanjing Li Xiuxiu Wang Zhongyu Ren Yanan Tian Jingxuan Zhao Wenyi Qi Hongbo Wang Ying Yu Rui Gong Hongyang Chen Haoyu Ji Fan Yang Wenya Ma Yu Liu Source Type: research

YBX1 promotes MSC osteogenic differentiation by activating the PI3K/AKT pathway
CONCLUSION: Our study provides a new target and theoretical basis for the treatment of bone diseases.PMID:35929633 | DOI:10.2174/1574888X17666220805143833
Source: Current Stem Cell Research and Therapy - August 5, 2022 Category: Stem Cells Authors: Jiayu Chen Zhanliang Liu Huicheng Zhang Yongqian Yang Huangxiang Zeng Rongwei Zhong Shangdao Lai Hongxing Liao Source Type: research

Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation
Int J Med Sci. 2022 Jul 11;19(8):1254-1264. doi: 10.7150/ijms.70743. eCollection 2022.ABSTRACTMammalian cardiomyocytes (CMs) maintain a low capacity for self-renewal in adulthood, therefore the induction of CMs cycle re-entry is an important approach to promote myocardial repair after injury. Recently, photobiomodulation (PBM) has been used to manipulate physiological activities of various tissues and organs by non-invasive means. Here, we demonstrate that conditioned PBM using light-emitting diodes with a wavelength of 630 nm (LED-Red) was capable of promoting the proliferation of neonatal CMs. Further studies showed that...
Source: International Journal of Medical Sciences - August 5, 2022 Category: Biomedical Science Authors: Xinlu Gao Hanjing Li Xiuxiu Wang Zhongyu Ren Yanan Tian Jingxuan Zhao Wenyi Qi Hongbo Wang Ying Yu Rui Gong Hongyang Chen Haoyu Ji Fan Yang Wenya Ma Yu Liu Source Type: research

YBX1 promotes MSC osteogenic differentiation by activating the PI3K/AKT pathway
CONCLUSION: Our study provides a new target and theoretical basis for the treatment of bone diseases.PMID:35929633 | DOI:10.2174/1574888X17666220805143833
Source: Current Stem Cell Research and Therapy - August 5, 2022 Category: Stem Cells Authors: Jiayu Chen Zhanliang Liu Huicheng Zhang Yongqian Yang Huangxiang Zeng Rongwei Zhong Shangdao Lai Hongxing Liao Source Type: research

Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation
Int J Med Sci. 2022 Jul 11;19(8):1254-1264. doi: 10.7150/ijms.70743. eCollection 2022.ABSTRACTMammalian cardiomyocytes (CMs) maintain a low capacity for self-renewal in adulthood, therefore the induction of CMs cycle re-entry is an important approach to promote myocardial repair after injury. Recently, photobiomodulation (PBM) has been used to manipulate physiological activities of various tissues and organs by non-invasive means. Here, we demonstrate that conditioned PBM using light-emitting diodes with a wavelength of 630 nm (LED-Red) was capable of promoting the proliferation of neonatal CMs. Further studies showed that...
Source: International Journal of Medical Sciences - August 5, 2022 Category: Biomedical Science Authors: Xinlu Gao Hanjing Li Xiuxiu Wang Zhongyu Ren Yanan Tian Jingxuan Zhao Wenyi Qi Hongbo Wang Ying Yu Rui Gong Hongyang Chen Haoyu Ji Fan Yang Wenya Ma Yu Liu Source Type: research

YBX1 promotes MSC osteogenic differentiation by activating the PI3K/AKT pathway
CONCLUSION: Our study provides a new target and theoretical basis for the treatment of bone diseases.PMID:35929633 | DOI:10.2174/1574888X17666220805143833
Source: Current Stem Cell Research and Therapy - August 5, 2022 Category: Stem Cells Authors: Jiayu Chen Zhanliang Liu Huicheng Zhang Yongqian Yang Huangxiang Zeng Rongwei Zhong Shangdao Lai Hongxing Liao Source Type: research

Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation
Int J Med Sci. 2022 Jul 11;19(8):1254-1264. doi: 10.7150/ijms.70743. eCollection 2022.ABSTRACTMammalian cardiomyocytes (CMs) maintain a low capacity for self-renewal in adulthood, therefore the induction of CMs cycle re-entry is an important approach to promote myocardial repair after injury. Recently, photobiomodulation (PBM) has been used to manipulate physiological activities of various tissues and organs by non-invasive means. Here, we demonstrate that conditioned PBM using light-emitting diodes with a wavelength of 630 nm (LED-Red) was capable of promoting the proliferation of neonatal CMs. Further studies showed that...
Source: International Journal of Medical Sciences - August 5, 2022 Category: Biomedical Science Authors: Xinlu Gao Hanjing Li Xiuxiu Wang Zhongyu Ren Yanan Tian Jingxuan Zhao Wenyi Qi Hongbo Wang Ying Yu Rui Gong Hongyang Chen Haoyu Ji Fan Yang Wenya Ma Yu Liu Source Type: research

YBX1 promotes MSC osteogenic differentiation by activating the PI3K/AKT pathway
CONCLUSION: Our study provides a new target and theoretical basis for the treatment of bone diseases.PMID:35929633 | DOI:10.2174/1574888X17666220805143833
Source: Current Stem Cell Research and Therapy - August 5, 2022 Category: Stem Cells Authors: Jiayu Chen Zhanliang Liu Huicheng Zhang Yongqian Yang Huangxiang Zeng Rongwei Zhong Shangdao Lai Hongxing Liao Source Type: research

Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation
Int J Med Sci. 2022 Jul 11;19(8):1254-1264. doi: 10.7150/ijms.70743. eCollection 2022.ABSTRACTMammalian cardiomyocytes (CMs) maintain a low capacity for self-renewal in adulthood, therefore the induction of CMs cycle re-entry is an important approach to promote myocardial repair after injury. Recently, photobiomodulation (PBM) has been used to manipulate physiological activities of various tissues and organs by non-invasive means. Here, we demonstrate that conditioned PBM using light-emitting diodes with a wavelength of 630 nm (LED-Red) was capable of promoting the proliferation of neonatal CMs. Further studies showed that...
Source: International Journal of Medical Sciences - August 5, 2022 Category: Biomedical Science Authors: Xinlu Gao Hanjing Li Xiuxiu Wang Zhongyu Ren Yanan Tian Jingxuan Zhao Wenyi Qi Hongbo Wang Ying Yu Rui Gong Hongyang Chen Haoyu Ji Fan Yang Wenya Ma Yu Liu Source Type: research

YBX1 promotes MSC osteogenic differentiation by activating the PI3K/AKT pathway
CONCLUSION: Our study provides a new target and theoretical basis for the treatment of bone diseases.PMID:35929633 | DOI:10.2174/1574888X17666220805143833
Source: Cell Research - August 5, 2022 Category: Cytology Authors: Jiayu Chen Zhanliang Liu Huicheng Zhang Yongqian Yang Huangxiang Zeng Rongwei Zhong Shangdao Lai Hongxing Liao Source Type: research

Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation
Int J Med Sci. 2022 Jul 11;19(8):1254-1264. doi: 10.7150/ijms.70743. eCollection 2022.ABSTRACTMammalian cardiomyocytes (CMs) maintain a low capacity for self-renewal in adulthood, therefore the induction of CMs cycle re-entry is an important approach to promote myocardial repair after injury. Recently, photobiomodulation (PBM) has been used to manipulate physiological activities of various tissues and organs by non-invasive means. Here, we demonstrate that conditioned PBM using light-emitting diodes with a wavelength of 630 nm (LED-Red) was capable of promoting the proliferation of neonatal CMs. Further studies showed that...
Source: International Journal of Medical Sciences - August 5, 2022 Category: Biomedical Science Authors: Xinlu Gao Hanjing Li Xiuxiu Wang Zhongyu Ren Yanan Tian Jingxuan Zhao Wenyi Qi Hongbo Wang Ying Yu Rui Gong Hongyang Chen Haoyu Ji Fan Yang Wenya Ma Yu Liu Source Type: research

YBX1 promotes MSC osteogenic differentiation by activating the PI3K/AKT pathway
CONCLUSION: Our study provides a new target and theoretical basis for the treatment of bone diseases.PMID:35929633 | DOI:10.2174/1574888X17666220805143833
Source: Current Stem Cell Research and Therapy - August 5, 2022 Category: Stem Cells Authors: Jiayu Chen Zhanliang Liu Huicheng Zhang Yongqian Yang Huangxiang Zeng Rongwei Zhong Shangdao Lai Hongxing Liao Source Type: research