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Total 964 results found since Jan 2013.

FoxO3 Modulates LPS-Activated Hepatic Inflammation in Turbot (Scophthalmus maximus L.)
In mammals, forkhead box O3 (foxo3) plays important roles in liver immune system. The foxo3 can regulate cell cycle, DNA repair, hypoxia, apoptosis and so on. However, as such an important transcription factor, few studies on foxo3 in fish have been reported. The present study characterized the foxo3 in turbot (Scophthalmus maximus L.). Lipopolysaccharide (LPS) incubated in vitro (hepatocytes) and injected in vivo (turbot liver) were used to construct inflammatory models. The foxo3 was interfered and overexpressed to investigate its functions in liver inflammation. The open reading frame (ORF) of foxo3 was 1998 bp (base pa...
Source: Frontiers in Immunology - July 1, 2021 Category: Allergy & Immunology Source Type: research

USP9X Is Required to Maintain Cell Survival in Response to High-LET Radiation
Ionizing radiation (IR) principally acts through induction of DNA damage that promotes cell death, although the biological effects of IR are more broad ranging. In fact, the impact of IR of higher-linear energy transfer (LET) on cell biology is generally not well understood. Critically, therefore, the cellular enzymes and mechanisms responsible for enhancing cell survival following high-LET IR are unclear. To this effect, we have recently performed siRNA screening to identify deubiquitylating enzymes that control cell survival specifically in response to high-LET α-particles and protons, in comparison to low-LET X-rays an...
Source: Frontiers in Oncology - July 1, 2021 Category: Cancer & Oncology Source Type: research

IGF-1R depletion sensitizes colon cancer cell lines to radiotherapy
CONCLUSION: Our findings demonstrate that depletion of IGF-1R lead to an increase in radiosensitivity in CRC.PMID:34092618 | DOI:10.3233/CBM-210016
Source: Cancer Biomarkers : Section A of Disease Markers - June 7, 2021 Category: Cancer & Oncology Authors: Rui Zong Xiaoman Chen Jingjing Feng Shan Xu Source Type: research