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Procedure: Gastroschisis Repair
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Total 964 results found since Jan 2013.
IGF-1R depletion sensitizes colon cancer cell lines to radiotherapy
CONCLUSION: Our findings demonstrate that depletion of IGF-1R lead to an increase in radiosensitivity in CRC.PMID:34092618 | DOI:10.3233/CBM-210016
Source: Cancer Biomarkers - June 7, 2021 Category: Cancer & Oncology Authors: Rui Zong Xiaoman Chen Jingjing Feng Shan Xu Source Type: research
Age-related defects in autophagy alter the secretion of paracrine factors from bone marrow mononuclear cells
Aging (Albany NY). 2021 Jun 4;13. doi: 10.18632/aging.203127. Online ahead of print.ABSTRACTBone marrow mononuclear cell therapy improves cardiac repair after myocardial infarction (MI), in-part through signaling to resident cardiac cells, such as fibroblasts, which regulate scar formation. The efficacy of cell therapy declines with age, as aging of both donor and recipient cells decreases repair responses. Autophagy regulates the microenvironment by both extracellular vesicle (EV)-dependent and independent secretion pathways. We hypothesized that age-related autophagy changes in bone marrow cells (BMCs) alter paracrine si...
Source: Aging - June 5, 2021 Category: Biomedical Science Authors: Azadeh Yeganeh Faisal J Alibhai Stephanie W Tobin Fievel Lim Jun Wu Shuhong Li Richard D Weisel Ren-Ke Li Source Type: research
Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions
J Toxicol Sci. 2021;46(6):283-288. doi: 10.2131/jts.46.283.ABSTRACTAbasic sites are formed in cells by various factors including environmental mutagens and considered to be involved in cancer initiation, promotion, and progression. A chemically stable abasic site analog (tetrahydrofuran-type analog, THF) induces untargeted base substitutions as well as targeted substitution and large deletion mutations in human cells. The untargeted substitutions may be initiated by the cleavage of the DNA strand bearing THF by the human apurinic/apyrimidinic endonuclease 1 (APE1) protein, the major repair enzyme for THF and abasic sites. ...
Source: Journal of Toxicological Sciences - June 3, 2021 Category: Toxicology Authors: Tetsuya Suzuki Yuri Katayama Yasuo Komatsu Hiroyuki Kamiya Source Type: research
