MicroRNA-182-5p and microRNA-205-5p as potential biomarkers for prognostic stratification of p16-positive oropharyngeal squamous cell carcinoma
CONCLUSIONS: Results indicate that miR-182-5p and miR-205-5p can further stratify patients with p16-positive OPSCC into prognostic groups.PMID:34542062 | DOI:10.3233/CBM-203149 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 20, 2021 Category: Cancer & Oncology Authors: Bernhard G Weiss Mahalia Zoe Anczykowski Friedrich Ihler Mattis Bertlich Jennifer L Spiegel Frank Haubner Martin Canis Stefan K üffer Julia Hess Kristian Unger Julia Kitz Mark Jakob Source Type: research

Antibody array-based proteomic screening of novel biomarkers in malignant biliary stricture
CONCLUSIONS: Lipocalin-2 and P-cadherin measurements in bile could be clinically useful for the detection of malignant biliary strictures.PMID:34542063 | DOI:10.3233/CBM-210095 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 20, 2021 Category: Cancer & Oncology Authors: Wen-Hao Qin Jun-Teng Liu Shu-Ping Wang Zhi-Shi Yang Kun-Ke Wang Bing Hu Source Type: research

LncRNA HCG11 promotes 5-FU resistance of colon cancer cells through reprogramming glucose metabolism by targeting the miR-144-3p-PDK4 axis
CONCLUSION: In summary, this study reveals critical roles and molecular mechanisms of the HCG11-mediated 5-FU resistance through modulating the miR-144-3p-PDK4-glucose metabolism pathway in CRC.PMID:34542064 | DOI:10.3233/CBM-210212 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 20, 2021 Category: Cancer & Oncology Authors: Zhi Cui Qi Wang Mu-Hong Deng Quan-Li Han Source Type: research

MicroRNA-182-5p and microRNA-205-5p as potential biomarkers for prognostic stratification of p16-positive oropharyngeal squamous cell carcinoma
CONCLUSIONS: Results indicate that miR-182-5p and miR-205-5p can further stratify patients with p16-positive OPSCC into prognostic groups.PMID:34542062 | DOI:10.3233/CBM-203149 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 20, 2021 Category: Cancer & Oncology Authors: Bernhard G Weiss Mahalia Zoe Anczykowski Friedrich Ihler Mattis Bertlich Jennifer L Spiegel Frank Haubner Martin Canis Stefan K üffer Julia Hess Kristian Unger Julia Kitz Mark Jakob Source Type: research

Antibody array-based proteomic screening of novel biomarkers in malignant biliary stricture
CONCLUSIONS: Lipocalin-2 and P-cadherin measurements in bile could be clinically useful for the detection of malignant biliary strictures.PMID:34542063 | DOI:10.3233/CBM-210095 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 20, 2021 Category: Cancer & Oncology Authors: Wen-Hao Qin Jun-Teng Liu Shu-Ping Wang Zhi-Shi Yang Kun-Ke Wang Bing Hu Source Type: research

LncRNA HCG11 promotes 5-FU resistance of colon cancer cells through reprogramming glucose metabolism by targeting the miR-144-3p-PDK4 axis
CONCLUSION: In summary, this study reveals critical roles and molecular mechanisms of the HCG11-mediated 5-FU resistance through modulating the miR-144-3p-PDK4-glucose metabolism pathway in CRC.PMID:34542064 | DOI:10.3233/CBM-210212 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 20, 2021 Category: Cancer & Oncology Authors: Zhi Cui Qi Wang Mu-Hong Deng Quan-Li Han Source Type: research

MicroRNA-182-5p and microRNA-205-5p as potential biomarkers for prognostic stratification of p16-positive oropharyngeal squamous cell carcinoma
CONCLUSIONS: Results indicate that miR-182-5p and miR-205-5p can further stratify patients with p16-positive OPSCC into prognostic groups.PMID:34542062 | DOI:10.3233/CBM-203149 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 20, 2021 Category: Cancer & Oncology Authors: Bernhard G Weiss Mahalia Zoe Anczykowski Friedrich Ihler Mattis Bertlich Jennifer L Spiegel Frank Haubner Martin Canis Stefan K üffer Julia Hess Kristian Unger Julia Kitz Mark Jakob Source Type: research

Antibody array-based proteomic screening of novel biomarkers in malignant biliary stricture
CONCLUSIONS: Lipocalin-2 and P-cadherin measurements in bile could be clinically useful for the detection of malignant biliary strictures.PMID:34542063 | DOI:10.3233/CBM-210095 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 20, 2021 Category: Cancer & Oncology Authors: Wen-Hao Qin Jun-Teng Liu Shu-Ping Wang Zhi-Shi Yang Kun-Ke Wang Bing Hu Source Type: research

LncRNA HCG11 promotes 5-FU resistance of colon cancer cells through reprogramming glucose metabolism by targeting the miR-144-3p-PDK4 axis
CONCLUSION: In summary, this study reveals critical roles and molecular mechanisms of the HCG11-mediated 5-FU resistance through modulating the miR-144-3p-PDK4-glucose metabolism pathway in CRC.PMID:34542064 | DOI:10.3233/CBM-210212 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 20, 2021 Category: Cancer & Oncology Authors: Zhi Cui Qi Wang Mu-Hong Deng Quan-Li Han Source Type: research

Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection
CONCLUSION: An elevated ΔNLR was a predictor of poor response to treatment and a prognostic factor for worse Overall Survival in pediatric patients with CNST undergoing surgical resection.PMID:34511483 | DOI:10.3233/CBM-200857 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Al Flores-Bustamante Laura Hern ández-Regino Manuel-De-Jes ús Castillejos-López Daniel Mart ínez-Rodríguez Arnoldo Aquino-G álvez Marta Zapata-Tarr és Armando de U ña-Flores Citlaltepetl Salinas-Lara Patricia Sierra-Vargas Luz Mar ía Torres-Espí Source Type: research

A pan-cancer analysis based on weighted gene co-expression network analysis identifies the biomarker utility of lamin B1 in human tumors
In this study, we first revealed the key role of LMNB1 in esophageal carcinoma (ESCA) through weighted gene co-expression network analysis (WGCNA) and disease-free survival (DFS) analysis. Based on this result and the datasets of the cancer genome atlas (TCGA), we explored the biomarker utility of LMNB1 across thirty-three tumors. We found that LMNB1 was highly expressed in most of the cancers and significant associations existed between LMNB1 expression and prognosis of cases of nearly half of the cancers. We also found that LMNB1 expression was associated with the infiltration level of Macrophages M1 and T cells CD4 memo...
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Youwei Hua Zhihui He Xu Zhang Source Type: research

Bioinformatics-guided analysis uncovers TIGIT as an epigenetically regulated immunomodulator affecting immunotherapeutic sensitivity of gastric cancer
CONCLUSION: TIGIT is an epigenetically regulated immunomodulator of gastric cancer which can modify the immune activity and affect immunotherapeutic sensitivity. These findings can promote the research of epigenetic therapies and improve the survival of cancer patients by sensitizing tumors to immune therapies.PMID:34511485 | DOI:10.3233/CBM-210159 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Jianfei Ma Source Type: research

Carboxypeptidase E mRNA: Overexpression predicts recurrence and death in lung adenocarcinoma cancer patients
CONCLUSIONS: CPE/CPE-ΔN mRNA is a potentially useful biomarker for predicting recurrence and death in LADC patients, especially in identifying patients at high risk of recurrence at early stages I and II.PMID:34511486 | DOI:10.3233/CBM-210206 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: I-Ying Kuo Danping Liu Wu-Wei Lai Yi-Ching Wang Y Peng Loh Source Type: research

Ascites in ovarian cancer: MicroRNA deregulations and their potential roles in ovarian carcinogenesis
Cancer Biomark. 2021 Sep 2. doi: 10.3233/CBM-210219. Online ahead of print.ABSTRACTOvarian cancer comprises the most lethal gynecologic malignancy and is accompanied by the high potential for the incidence of metastasis, recurrence and chemotherapy resistance, often associated with a formation of ascitic fluid. The differentially expressed ascites-derived microRNAs may be linked to ovarian carcinogenesis. The article focuses on a number of miRNAs that share a common expression pattern as determined by independent studies using ascites samples and with regard to their functions and outcomes in experimental and clinical inve...
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Lud ěk Záveský Eva Jand áková V ít Weinberger Veronika Hanz íková Ond řej Slanař Milada Kohoutov á Source Type: research

Application of a multiplex urinalysis test for the prediction of intravesical BCG treatment response: A pilot study
CONCLUSIONS: Monitoring the urinary levels of a cancer-associated biomarker panel enabled the discrimination of patients who did not respond to intravesical BCG therapy. With further study, the multiplex OncuriaTM test may be applicable for the clinical evaluation of bladder cancer patients considering intravesical BCG treatment.PMID:34511488 | DOI:10.3233/CBM-210221 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Kaoru Murakami Ashish M Kamat Yunfeng Dai Ian Pagano Runpu Chen Yijun Sun Amit Gupta Steve Goodison Charles J Rosser Hideki Furuya Source Type: research

Differential gene expression analysis for osteosarcoma lung metastases
CONCLUSION: This integrated study hypothesized several miRNA dependent signaling pathway for OS patients with lung metastases and initiated a potential strategy for better understanding the lung metastases in clinic.PMID:34511489 | DOI:10.3233/CBM-210232 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Fengsong Liu Xiaojian Pang Ziqi Yu Kai Wang Source Type: research

Erratum
Cancer Biomark. 2021 Sep 3. doi: 10.3233/CBM-219528. Online ahead of print.NO ABSTRACTPMID:34511530 | DOI:10.3233/CBM-219528 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Source Type: research

Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection
CONCLUSION: An elevated ΔNLR was a predictor of poor response to treatment and a prognostic factor for worse Overall Survival in pediatric patients with CNST undergoing surgical resection.PMID:34511483 | DOI:10.3233/CBM-200857 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Al Flores-Bustamante Laura Hern ández-Regino Manuel-De-Jes ús Castillejos-López Daniel Mart ínez-Rodríguez Arnoldo Aquino-G álvez Marta Zapata-Tarr és Armando de U ña-Flores Citlaltepetl Salinas-Lara Patricia Sierra-Vargas Luz Mar ía Torres-Espí Source Type: research

A pan-cancer analysis based on weighted gene co-expression network analysis identifies the biomarker utility of lamin B1 in human tumors
In this study, we first revealed the key role of LMNB1 in esophageal carcinoma (ESCA) through weighted gene co-expression network analysis (WGCNA) and disease-free survival (DFS) analysis. Based on this result and the datasets of the cancer genome atlas (TCGA), we explored the biomarker utility of LMNB1 across thirty-three tumors. We found that LMNB1 was highly expressed in most of the cancers and significant associations existed between LMNB1 expression and prognosis of cases of nearly half of the cancers. We also found that LMNB1 expression was associated with the infiltration level of Macrophages M1 and T cells CD4 memo...
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Youwei Hua Zhihui He Xu Zhang Source Type: research

Bioinformatics-guided analysis uncovers TIGIT as an epigenetically regulated immunomodulator affecting immunotherapeutic sensitivity of gastric cancer
CONCLUSION: TIGIT is an epigenetically regulated immunomodulator of gastric cancer which can modify the immune activity and affect immunotherapeutic sensitivity. These findings can promote the research of epigenetic therapies and improve the survival of cancer patients by sensitizing tumors to immune therapies.PMID:34511485 | DOI:10.3233/CBM-210159 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Jianfei Ma Source Type: research

Carboxypeptidase E mRNA: Overexpression predicts recurrence and death in lung adenocarcinoma cancer patients
CONCLUSIONS: CPE/CPE-ΔN mRNA is a potentially useful biomarker for predicting recurrence and death in LADC patients, especially in identifying patients at high risk of recurrence at early stages I and II.PMID:34511486 | DOI:10.3233/CBM-210206 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: I-Ying Kuo Danping Liu Wu-Wei Lai Yi-Ching Wang Y Peng Loh Source Type: research

Ascites in ovarian cancer: MicroRNA deregulations and their potential roles in ovarian carcinogenesis
Cancer Biomark. 2021 Sep 2. doi: 10.3233/CBM-210219. Online ahead of print.ABSTRACTOvarian cancer comprises the most lethal gynecologic malignancy and is accompanied by the high potential for the incidence of metastasis, recurrence and chemotherapy resistance, often associated with a formation of ascitic fluid. The differentially expressed ascites-derived microRNAs may be linked to ovarian carcinogenesis. The article focuses on a number of miRNAs that share a common expression pattern as determined by independent studies using ascites samples and with regard to their functions and outcomes in experimental and clinical inve...
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Lud ěk Záveský Eva Jand áková V ít Weinberger Veronika Hanz íková Ond řej Slanař Milada Kohoutov á Source Type: research

Application of a multiplex urinalysis test for the prediction of intravesical BCG treatment response: A pilot study
CONCLUSIONS: Monitoring the urinary levels of a cancer-associated biomarker panel enabled the discrimination of patients who did not respond to intravesical BCG therapy. With further study, the multiplex OncuriaTM test may be applicable for the clinical evaluation of bladder cancer patients considering intravesical BCG treatment.PMID:34511488 | DOI:10.3233/CBM-210221 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Kaoru Murakami Ashish M Kamat Yunfeng Dai Ian Pagano Runpu Chen Yijun Sun Amit Gupta Steve Goodison Charles J Rosser Hideki Furuya Source Type: research

Differential gene expression analysis for osteosarcoma lung metastases
CONCLUSION: This integrated study hypothesized several miRNA dependent signaling pathway for OS patients with lung metastases and initiated a potential strategy for better understanding the lung metastases in clinic.PMID:34511489 | DOI:10.3233/CBM-210232 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Fengsong Liu Xiaojian Pang Ziqi Yu Kai Wang Source Type: research

Erratum
Cancer Biomark. 2021 Sep 3. doi: 10.3233/CBM-219528. Online ahead of print.NO ABSTRACTPMID:34511530 | DOI:10.3233/CBM-219528 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Source Type: research

Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection
CONCLUSION: An elevated ΔNLR was a predictor of poor response to treatment and a prognostic factor for worse Overall Survival in pediatric patients with CNST undergoing surgical resection.PMID:34511483 | DOI:10.3233/CBM-200857 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Al Flores-Bustamante Laura Hern ández-Regino Manuel-De-Jes ús Castillejos-López Daniel Mart ínez-Rodríguez Arnoldo Aquino-G álvez Marta Zapata-Tarr és Armando de U ña-Flores Citlaltepetl Salinas-Lara Patricia Sierra-Vargas Luz Mar ía Torres-Espí Source Type: research

A pan-cancer analysis based on weighted gene co-expression network analysis identifies the biomarker utility of lamin B1 in human tumors
In this study, we first revealed the key role of LMNB1 in esophageal carcinoma (ESCA) through weighted gene co-expression network analysis (WGCNA) and disease-free survival (DFS) analysis. Based on this result and the datasets of the cancer genome atlas (TCGA), we explored the biomarker utility of LMNB1 across thirty-three tumors. We found that LMNB1 was highly expressed in most of the cancers and significant associations existed between LMNB1 expression and prognosis of cases of nearly half of the cancers. We also found that LMNB1 expression was associated with the infiltration level of Macrophages M1 and T cells CD4 memo...
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Youwei Hua Zhihui He Xu Zhang Source Type: research

Bioinformatics-guided analysis uncovers TIGIT as an epigenetically regulated immunomodulator affecting immunotherapeutic sensitivity of gastric cancer
CONCLUSION: TIGIT is an epigenetically regulated immunomodulator of gastric cancer which can modify the immune activity and affect immunotherapeutic sensitivity. These findings can promote the research of epigenetic therapies and improve the survival of cancer patients by sensitizing tumors to immune therapies.PMID:34511485 | DOI:10.3233/CBM-210159 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Jianfei Ma Source Type: research

Carboxypeptidase E mRNA: Overexpression predicts recurrence and death in lung adenocarcinoma cancer patients
CONCLUSIONS: CPE/CPE-ΔN mRNA is a potentially useful biomarker for predicting recurrence and death in LADC patients, especially in identifying patients at high risk of recurrence at early stages I and II.PMID:34511486 | DOI:10.3233/CBM-210206 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: I-Ying Kuo Danping Liu Wu-Wei Lai Yi-Ching Wang Y Peng Loh Source Type: research

Ascites in ovarian cancer: MicroRNA deregulations and their potential roles in ovarian carcinogenesis
Cancer Biomark. 2021 Sep 2. doi: 10.3233/CBM-210219. Online ahead of print.ABSTRACTOvarian cancer comprises the most lethal gynecologic malignancy and is accompanied by the high potential for the incidence of metastasis, recurrence and chemotherapy resistance, often associated with a formation of ascitic fluid. The differentially expressed ascites-derived microRNAs may be linked to ovarian carcinogenesis. The article focuses on a number of miRNAs that share a common expression pattern as determined by independent studies using ascites samples and with regard to their functions and outcomes in experimental and clinical inve...
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Lud ěk Záveský Eva Jand áková V ít Weinberger Veronika Hanz íková Ond řej Slanař Milada Kohoutov á Source Type: research

Application of a multiplex urinalysis test for the prediction of intravesical BCG treatment response: A pilot study
CONCLUSIONS: Monitoring the urinary levels of a cancer-associated biomarker panel enabled the discrimination of patients who did not respond to intravesical BCG therapy. With further study, the multiplex OncuriaTM test may be applicable for the clinical evaluation of bladder cancer patients considering intravesical BCG treatment.PMID:34511488 | DOI:10.3233/CBM-210221 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Kaoru Murakami Ashish M Kamat Yunfeng Dai Ian Pagano Runpu Chen Yijun Sun Amit Gupta Steve Goodison Charles J Rosser Hideki Furuya Source Type: research

Differential gene expression analysis for osteosarcoma lung metastases
CONCLUSION: This integrated study hypothesized several miRNA dependent signaling pathway for OS patients with lung metastases and initiated a potential strategy for better understanding the lung metastases in clinic.PMID:34511489 | DOI:10.3233/CBM-210232 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Fengsong Liu Xiaojian Pang Ziqi Yu Kai Wang Source Type: research

Erratum
Cancer Biomark. 2021 Sep 3. doi: 10.3233/CBM-219528. Online ahead of print.NO ABSTRACTPMID:34511530 | DOI:10.3233/CBM-219528 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Source Type: research

Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection
CONCLUSION: An elevated ΔNLR was a predictor of poor response to treatment and a prognostic factor for worse Overall Survival in pediatric patients with CNST undergoing surgical resection.PMID:34511483 | DOI:10.3233/CBM-200857 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Al Flores-Bustamante Laura Hern ández-Regino Manuel-De-Jes ús Castillejos-López Daniel Mart ínez-Rodríguez Arnoldo Aquino-G álvez Marta Zapata-Tarr és Armando de U ña-Flores Citlaltepetl Salinas-Lara Patricia Sierra-Vargas Luz Mar ía Torres-Espí Source Type: research

A pan-cancer analysis based on weighted gene co-expression network analysis identifies the biomarker utility of lamin B1 in human tumors
In this study, we first revealed the key role of LMNB1 in esophageal carcinoma (ESCA) through weighted gene co-expression network analysis (WGCNA) and disease-free survival (DFS) analysis. Based on this result and the datasets of the cancer genome atlas (TCGA), we explored the biomarker utility of LMNB1 across thirty-three tumors. We found that LMNB1 was highly expressed in most of the cancers and significant associations existed between LMNB1 expression and prognosis of cases of nearly half of the cancers. We also found that LMNB1 expression was associated with the infiltration level of Macrophages M1 and T cells CD4 memo...
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Youwei Hua Zhihui He Xu Zhang Source Type: research

Bioinformatics-guided analysis uncovers TIGIT as an epigenetically regulated immunomodulator affecting immunotherapeutic sensitivity of gastric cancer
CONCLUSION: TIGIT is an epigenetically regulated immunomodulator of gastric cancer which can modify the immune activity and affect immunotherapeutic sensitivity. These findings can promote the research of epigenetic therapies and improve the survival of cancer patients by sensitizing tumors to immune therapies.PMID:34511485 | DOI:10.3233/CBM-210159 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Jianfei Ma Source Type: research

Carboxypeptidase E mRNA: Overexpression predicts recurrence and death in lung adenocarcinoma cancer patients
CONCLUSIONS: CPE/CPE-ΔN mRNA is a potentially useful biomarker for predicting recurrence and death in LADC patients, especially in identifying patients at high risk of recurrence at early stages I and II.PMID:34511486 | DOI:10.3233/CBM-210206 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: I-Ying Kuo Danping Liu Wu-Wei Lai Yi-Ching Wang Y Peng Loh Source Type: research

Ascites in ovarian cancer: MicroRNA deregulations and their potential roles in ovarian carcinogenesis
Cancer Biomark. 2021 Sep 2. doi: 10.3233/CBM-210219. Online ahead of print.ABSTRACTOvarian cancer comprises the most lethal gynecologic malignancy and is accompanied by the high potential for the incidence of metastasis, recurrence and chemotherapy resistance, often associated with a formation of ascitic fluid. The differentially expressed ascites-derived microRNAs may be linked to ovarian carcinogenesis. The article focuses on a number of miRNAs that share a common expression pattern as determined by independent studies using ascites samples and with regard to their functions and outcomes in experimental and clinical inve...
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Lud ěk Záveský Eva Jand áková V ít Weinberger Veronika Hanz íková Ond řej Slanař Milada Kohoutov á Source Type: research

Application of a multiplex urinalysis test for the prediction of intravesical BCG treatment response: A pilot study
CONCLUSIONS: Monitoring the urinary levels of a cancer-associated biomarker panel enabled the discrimination of patients who did not respond to intravesical BCG therapy. With further study, the multiplex OncuriaTM test may be applicable for the clinical evaluation of bladder cancer patients considering intravesical BCG treatment.PMID:34511488 | DOI:10.3233/CBM-210221 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Kaoru Murakami Ashish M Kamat Yunfeng Dai Ian Pagano Runpu Chen Yijun Sun Amit Gupta Steve Goodison Charles J Rosser Hideki Furuya Source Type: research

Differential gene expression analysis for osteosarcoma lung metastases
CONCLUSION: This integrated study hypothesized several miRNA dependent signaling pathway for OS patients with lung metastases and initiated a potential strategy for better understanding the lung metastases in clinic.PMID:34511489 | DOI:10.3233/CBM-210232 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Fengsong Liu Xiaojian Pang Ziqi Yu Kai Wang Source Type: research

Erratum
Cancer Biomark. 2021 Sep 3. doi: 10.3233/CBM-219528. Online ahead of print.NO ABSTRACTPMID:34511530 | DOI:10.3233/CBM-219528 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Source Type: research

Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection
CONCLUSION: An elevated ΔNLR was a predictor of poor response to treatment and a prognostic factor for worse Overall Survival in pediatric patients with CNST undergoing surgical resection.PMID:34511483 | DOI:10.3233/CBM-200857 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Al Flores-Bustamante Laura Hern ández-Regino Manuel-De-Jes ús Castillejos-López Daniel Mart ínez-Rodríguez Arnoldo Aquino-G álvez Marta Zapata-Tarr és Armando de U ña-Flores Citlaltepetl Salinas-Lara Patricia Sierra-Vargas Luz Mar ía Torres-Espí Source Type: research

A pan-cancer analysis based on weighted gene co-expression network analysis identifies the biomarker utility of lamin B1 in human tumors
In this study, we first revealed the key role of LMNB1 in esophageal carcinoma (ESCA) through weighted gene co-expression network analysis (WGCNA) and disease-free survival (DFS) analysis. Based on this result and the datasets of the cancer genome atlas (TCGA), we explored the biomarker utility of LMNB1 across thirty-three tumors. We found that LMNB1 was highly expressed in most of the cancers and significant associations existed between LMNB1 expression and prognosis of cases of nearly half of the cancers. We also found that LMNB1 expression was associated with the infiltration level of Macrophages M1 and T cells CD4 memo...
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Youwei Hua Zhihui He Xu Zhang Source Type: research

Bioinformatics-guided analysis uncovers TIGIT as an epigenetically regulated immunomodulator affecting immunotherapeutic sensitivity of gastric cancer
CONCLUSION: TIGIT is an epigenetically regulated immunomodulator of gastric cancer which can modify the immune activity and affect immunotherapeutic sensitivity. These findings can promote the research of epigenetic therapies and improve the survival of cancer patients by sensitizing tumors to immune therapies.PMID:34511485 | DOI:10.3233/CBM-210159 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Jianfei Ma Source Type: research

Carboxypeptidase E mRNA: Overexpression predicts recurrence and death in lung adenocarcinoma cancer patients
CONCLUSIONS: CPE/CPE-ΔN mRNA is a potentially useful biomarker for predicting recurrence and death in LADC patients, especially in identifying patients at high risk of recurrence at early stages I and II.PMID:34511486 | DOI:10.3233/CBM-210206 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: I-Ying Kuo Danping Liu Wu-Wei Lai Yi-Ching Wang Y Peng Loh Source Type: research

Ascites in ovarian cancer: MicroRNA deregulations and their potential roles in ovarian carcinogenesis
Cancer Biomark. 2021 Sep 2. doi: 10.3233/CBM-210219. Online ahead of print.ABSTRACTOvarian cancer comprises the most lethal gynecologic malignancy and is accompanied by the high potential for the incidence of metastasis, recurrence and chemotherapy resistance, often associated with a formation of ascitic fluid. The differentially expressed ascites-derived microRNAs may be linked to ovarian carcinogenesis. The article focuses on a number of miRNAs that share a common expression pattern as determined by independent studies using ascites samples and with regard to their functions and outcomes in experimental and clinical inve...
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Lud ěk Záveský Eva Jand áková V ít Weinberger Veronika Hanz íková Ond řej Slanař Milada Kohoutov á Source Type: research

Application of a multiplex urinalysis test for the prediction of intravesical BCG treatment response: A pilot study
CONCLUSIONS: Monitoring the urinary levels of a cancer-associated biomarker panel enabled the discrimination of patients who did not respond to intravesical BCG therapy. With further study, the multiplex OncuriaTM test may be applicable for the clinical evaluation of bladder cancer patients considering intravesical BCG treatment.PMID:34511488 | DOI:10.3233/CBM-210221 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Kaoru Murakami Ashish M Kamat Yunfeng Dai Ian Pagano Runpu Chen Yijun Sun Amit Gupta Steve Goodison Charles J Rosser Hideki Furuya Source Type: research

Differential gene expression analysis for osteosarcoma lung metastases
CONCLUSION: This integrated study hypothesized several miRNA dependent signaling pathway for OS patients with lung metastases and initiated a potential strategy for better understanding the lung metastases in clinic.PMID:34511489 | DOI:10.3233/CBM-210232 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Fengsong Liu Xiaojian Pang Ziqi Yu Kai Wang Source Type: research

Erratum
Cancer Biomark. 2021 Sep 3. doi: 10.3233/CBM-219528. Online ahead of print.NO ABSTRACTPMID:34511530 | DOI:10.3233/CBM-219528 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Source Type: research

Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection
CONCLUSION: An elevated ΔNLR was a predictor of poor response to treatment and a prognostic factor for worse Overall Survival in pediatric patients with CNST undergoing surgical resection.PMID:34511483 | DOI:10.3233/CBM-200857 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 13, 2021 Category: Cancer & Oncology Authors: Al Flores-Bustamante Laura Hern ández-Regino Manuel-De-Jes ús Castillejos-López Daniel Mart ínez-Rodríguez Arnoldo Aquino-G álvez Marta Zapata-Tarr és Armando de U ña-Flores Citlaltepetl Salinas-Lara Patricia Sierra-Vargas Luz Mar ía Torres-Espí Source Type: research