Serum netrin-1 as a biomarker for colorectal cancer detection.
This study was to evaluate the performance of serum netrin-1 for detection of colorectal cancer (CRC) in both clinical/screening sets. METHODS: A total of 115 consecutive patients with CRC and matched healthy controls were included in Clinical Set. Fifty subjects with CRC, 50 subjects with advanced adenoma (AA), and 150 matched control participants free of neoplasia were included in Screening Set. RESULTS: In Clinical set, subjects with CRC presented higher levels of serum netrin-1 (513.9 ± 22.6 pg/mL) than controls (347.8 ± 20.3 pg/mL, p
Source: Cancer Biomarkers - June 1, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

MiR-204-5p/TFAP2A feedback loop positively regulates the proliferation, migration, invasion and EMT process in cervical cancer.
In conclusion, miR-204-5p/TFAP2A feedback loop promoted the proliferative and motorial capacities of cervical cancer cells. This finding suggested a novel modulatory loop of miR-204-5p/TFAP2A in cervical cancer, offering promising biomarkers for cervical cancer therapy. PMID: 32474464 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - June 1, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Four genes relevant to pathological grade and prognosis in ovarian cancer.
CONCLUSIONS: In conclusion, 4 hub genes (MS4A4A, CD163, CPR65, MS4A6A) were verified associated with pathological grade of ovarian cancer. Moreover, MS4A4A, CD163, MS4A6A may serve as a surface marker for M2 macrophages. Targeting the 4 hub genes may can improve the prognosis of ovarian cancer. PMID: 32444534 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - May 25, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

CD133 expressionand clinicopathologic significance in benign and malignant breast lesions.
CONCLUSION: CD133 may play an important role in the occurrence and development of breast cancer. CD133 positive breast cancer cells are closely related to invasiveness and its expression may predict a poor prognosis. PMID: 32390595 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - May 12, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Expression of FOXM1 and Aurora-A predicts prognosis and sorafenib efficacy in patients with hepatocellular carcinoma.
CONCLUSIONS: The co-expression of FOXM1 and Aurora-A could be a reliable biomarker to predict the sorafenib response and prognosis of HCC patients. PMID: 32390596 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - May 12, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Identifying the mRNAs associated with Bladder cancer recurrence.
CONCLUSION: COL4A1, COL1A2 and COL5A1 could be associated with BC recurrence. PMID: 32390597 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - May 12, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Circular RNA circ_0000337 contributes to osteosarcoma via the iR-4458/BACH1 pathway.
CONCLUSIONS: This research for the first time documented that circ_0000337 promoted OS progression via sponging miR-4458 and thus elevating BACH1 expression, offering rational therapeutic target for OS. PMID: 32390598 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - May 12, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

5-aminolevulinic-acid-mediated sonodynamic therapy improves the prognosis of melanoma by inhibiting survivin expression.
CONCLUSION: Our results suggest that 5-ALA-mediated sonodynamic therapy inhibited B16-F10 cell proliferation and melanoma-xenograft growth and prolonged survival of melanoma-bearing nude mice, which might be through downregulation of survivin expression. PMID: 32390599 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - May 12, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Alterations of regulatory factors and DNA methylation pattern in thyroid cancer.
Authors: Iancu IV, Botezatu A, Plesa A, Huica I, Fudulu A, Albulescu A, Bostan M, Mihaila M, Grancea C, Manda DA, Dobrescu R, Vladoiu SV, Anton G, Badiu CV Abstract PURPOSE: DNA methylation plays an important role in thyroid oncogenesis. The aim of this study was to investigate the connection between global and local DNA methylation status and to establish the levels of important DNA methylation regulators (TET family and DNMT1) in thyroid tumours: follicular adenoma-FA, papillary thyroid carcinoma-PTC (classic papillary thyroid carcinoma-cPTC and papillary thyroid carcinoma follicular variant fvPTC). METHODS: ...
Source: Cancer Biomarkers - May 12, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Immunosuppressive receptor LILRB1 acts as a potential regulator in hepatocellular carcinoma by integrating with SHP1.
CONCLUSIONS: LILRB1 possibly plays an antitumor effect in hepatocarcinoma cells by integrating SHP1, providing evidence that LILRB1 might be involved in the pathologic progression of HCC. PMID: 32390601 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - May 12, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

LINC00174 is a favorable prognostic biomarker in glioblastoma via promoting proliferative phenotype.
CONCLUSION: LINC00174 acts as an oncogene in glioma and may be a new potential therapeutic target. PMID: 32390602 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - May 12, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Prognostic value of miR-892a in gastric cancer and its regulatory effect on tumor progression.
CONCLUSION: miR-892a was upregulated and predictor of poor prognosis in gastric cancer patients. The miR-892a in gastric cancer cells significantly promoted cell proliferative, migratory, and invasive properties. Furthermore, miR-892a may be served as a prognostic marker as well as a therapeutic target for gastric cancer. PMID: 32390603 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - May 12, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

High expression of IGF2-derived intronic miR-483 predicts outcome in hepatoblastoma.
CONCLUSIONS: The expansion of the four-miR signature by miR-483 serves as a useful biomarker to predict outcome of HB patients. PMID: 32390604 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - May 12, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Prognostic significance of elevated pretreatment serum levels of CEA and CA-125 in epithelial ovarian cancer.
Authors: Lin YH, Wu CH, Fu HC, Chen YJ, Chen YY, Ou YC, Lin H Abstract BACKGROUND: Epithelial ovarian cancer is a highly lethal gynecological malignancy. Accurate and cost-effective predictive tools to estimate the prognosis of patients with epithelial ovarian cancer before treatment are currently lacking. OBJECTIVE: The purpose of this study was to evaluate the prognostic significance of pretreatment serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen-125 (CA-125) in primary epithelial ovarian cancer. METHODS: Between 2008 and 2016, 326 patients with a diagnosis of primary epithelial ov...
Source: Cancer Biomarkers - May 12, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Claudin-6 is down-regulated in gastric cancer and its potential pathway.
Authors: Lu YZ, Li Y, Zhang T, Han ST Abstract Claudins are indispensible in modulating the permeability of epithelial and endothelial cells and in the maintenance of cell polarity. In order to verify the function of claudin-6 in the development of gastric cancer, we investigated claudin-6 expression in different gastric disease tissues. Moreover, we further explored whether overexpression of claudin-6 altered proliferation, apoptosis, migration, invasiveness, differentiation in BGC-823 cells and the potential mechanism. Immunohistochemistry was performed to detect the in situ expression of claudin-6 in different g...
Source: Cancer Biomarkers - May 12, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Arsenic trioxide-induced upregulation of miR-1294 suppresses tumor growth in hepatocellular carcinoma by targeting TEAD1 and PIM1.
Authors: Cai X, Yu L, Chen Z, Ye F, Ren Z, Jin P Abstract Recently, Arsenic trioxide (ATO) has been reported as an efficient drug for suppression of cancer cell growth. Existing studies revealed the extensive involvement of microRNAs (miRNAs) in initiation and development of hepatocellular carcinoma (HCC). However, the potential correlation between ATO and miRNAs in HCC progression remains to be explored. To conduct our research, we applied a qRT-PCR analysis to find miRNAs that were upregulated in HCC cells treated with ATO. In our present study, miR-1294 was found to be significantly upregulated in ATO-treated HC...
Source: Cancer Biomarkers - April 15, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Circulating cell-free DNA (cfDNA) levels in BRCA1 and BRCA2 mutation carriers: A preliminary study.
Authors: Douvdevani A, Bernstein-Molho R, Asraf K, Doolman R, Laitman Y, Friedman E Abstract BACKGROUND: Female carriers of BRCA1 or BRCA2 germline mutations are at a substantially increased risk for developing breast and ovarian cancer. The lack of effective early detection schemes for ovarian cancer, mandate surgical removal of adnexa at age 35-40 years in these high-risk women. The role of circulating cell-free DNA (cfDNA) levels as a marker for early detection in high-risk women has rarely been reported. OBJECTIVE: To quantify cfDNA levels in BRCA1BRCA2 carriers. METHODS: Serum cfDNA levels, measured by...
Source: Cancer Biomarkers - April 15, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Erratum.
Authors: PMID: 32250287 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - April 8, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Molecular characterisation in tongue squamous cell carcinoma reveals key variants potentially linked to clinical outcomes.
Authors: Alsofyani AA, Dallol A, Farraj SA, Alsiary RA, Samkari A, Alhaj-Hussain BT, Khan JA, Al-Maghrabi J, Al-Khayyat SS, Alkhatabi H, Elaimi A, Buhmeida A, Johargy AK, Abuzenadah AM, Azhar EI, Al-Qahtani MH Abstract BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) is a highly aggressive malignancy characterized by frequent recurrence, poor survival with relatively few therapeutic options due to the late diagnosis in many cases. OBJECTIVES: Understanding the molecular pathways underlying OTSCC tumourigenesis and the discovery of diagnostic and/or prognostic biomarkers. METHODS: We performed high-th...
Source: Cancer Biomarkers - April 8, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

CYFRA 21-1 levels in cerebrospinal fluid as a putative therapeutic monitoring biomarker for patients with leptomeningeal carcinomatosis: A pilot study.
CONCLUSIONS: CSF CYFRA 21-1 may have utility as a therapeutic monitoring biomarker to design personalized therapeutic strategies in LMC patients undergoing VLP chemotherapy. PMID: 32176621 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Knockdown of long non-coding RNA GHET1 suppresses cervical carcinoma in vitro and in vivo.
Authors: Ling W, Yangchun X, Wei W, Qiang W Abstract INTRODUCTION: The present study evaluated the effects of the long non-coding RNA (lncRNA) gastric carcinoma high-expressed transcript (GHET1) in cervical carcinoma development. METHODS: The expression levels of GHET1 and PTEN were measured using in situ hybridisation, immunohistochemistry (IHC) and quantitative reverse transcription PCR assay to investigate their correlations. In an in vitro study, the effects of GHET1 knockdown on the biological activities of SiHa and HeLa cells were evaluated by MTT, flow cytometry, transwell and wound-healing assays and re...
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Electronic nose to distinguish bladder cancer by urinary odour feature: A pilot study.
Authors: Matsumoto K, Murakami Y, Shimizu Y, Hirayama T, Ishikawa W, Iwamura M Abstract BACKGROUND: No study has yet investigated the use of electronic nose (eNose) technology to reveal pattern recognition of urological diseases, including bladder cancer. OBJECTIVE: We sought to determine the diagnostic performance of the eNose in recognizing urinary odour in patients with bladder cancer. METHODS: The eNose is a commercially available model equipped with two sensors. The angle of the two sensors (θ) depends on the kinds of chemical substances, thus defining θ as the feature of odour. Quantity of...
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

HOTAIR inhibits the proliferation of glioblastoma cells by targeting miR-219.
Authors: Li H, Guan C Abstract BACKGROUND: To investigate the influences of HOX transcript antisense ribonucleic acid (HOTAIR) on the proliferation and apoptosis of glioblastoma cells by targeting micro RNA (miR)-219. OBJECTIVE: With glioblastoma cell line U87 as the object, the changes in expression levels of HOTAIR and miR-219 in each group were detected via quantitative real-time polymerase chain reaction (qRT-PCR) after HOTAIR in U87 cell lines was knocked down using small interfering RNA (siRNA). Then the cell proliferation in each group was determined using Cell Counting Kit-8 (CCK-8) and colony formation...
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Utility of urinary ctDNA to monitoring minimal residual disease in early breast cancer patients.
CONCLUSION: Urinary DNA offers non-invasive probing and real-time monitoring of breast cancer relapse. Our results demonstrated clear clinical relevance in breast cancer and significant risk profiling of early breast cancer patients. This potentially aids to complement current cancer relapse monitoring and may help in early intervention. PMID: 32176625 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Systematic investigation of biomarker-like role of ARHGDIB in breast cancer.
CONCLUSIONS: Hence, our results suggested the significance and predictive role of ARHGDIB in breast cancer. High expression of ARHGDIB indicated the poor prognosis for breast cancer patients. PMID: 32176626 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

LINC00467 knockdown repressed cell proliferation but stimulated cell apoptosis in glioblastoma via miR-339-3p/IP6K2 axis.
CONCLUSIONS: LINC00467 knockdown repressed cell proliferation but stimulated cell apoptosis in glioblastoma via miR-339-3p/IP6K2 axis, which may enlighten to find a novel therapeutic tactic for glioblastoma patients. PMID: 32176627 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

The interactome of the prostate-specific protein Anoctamin 7.
CONCLUSIONS: This is the first study in which ANO7 interacting proteins have been identified. Although further studies are needed, the findings reported here expand our understanding of the role and regulation of ANO7 in prostate cancer cells. Furthermore, these results are likely to introduce new targets for the novel cancer therapies. PMID: 32176628 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Circulating cell-free DNA variables as marker of ovarian cancer patients: A pilot study.
CONCLUSIONS: cfDNA variables might be potentially diagnostic biomarkers in ovarian cancer, in combination with additional molecular markers. However, further studies are needed to confirm the diagnostic ability of cfDNA variables (cfDNA concentration and cfDI). PMID: 32176629 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Association analyses of a genetic variant in long non-coding RNA MEG3 with breast cancer susceptibility and serum MEG3 expression level in the Egyptian population.
Authors: Ali MA, Shaker OG, Alazrak M, AbdelHafez MN, Khalefa AA, Hemeda NF, Abdelmoktader A, Ahmed FA Abstract BACKGROUND: LncRNA MEG3 rs7158663 has been shown to confer cancer susceptibility, maybe through altering its gene expression level. OBJECTIVE: We aimed to weigh the effect of rs7158663 on MEG3 serum level and breast cancer susceptibility. METHODS: We genotyped rs7158663 G> A and measured serum MEG3 in 150 breast cancer, 95 FA, and 154 controls by the TaqMan method. RESULTS: The presence of rs7158663 G> A is a risk factor for breast cancer among fibroadenoma patients and controls, AA vs. ...
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

miR-654-3p predicts the prognosis of hepatocellular carcinoma and inhibits the proliferation, migration, and invasion of cancer cells.
CONCLUSION: Our study suggested that miR-654-3p expression was downregulated in HCC and might serve as a potential prognostic marker and therapeutic target for the survival of HCC patients. miR-654-3p might exert a suppressor role in HCC through inhibiting tumor cell proliferation, migration, and invasion. PMID: 32176631 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

LGR4 overexpression is associated with clinical parameters and poor prognosis of serous ovarian cancer.
CONCLUSION: LGR4 is upregulated in serous ovarian cancer, and LGR4 is an indeed useful independent prognostic predictor in serous ovarian cancer, and it may provide important clinical value of serous ovarian cancer. PMID: 32176632 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Plasma exosome-derived microRNA-532 as a novel predictor for acute myeloid leukemia.
CONCLUSION: We found plasma exosome-derived microRNA-532 can be used as a novel survival predictor for acute myeloid leukemia. PMID: 32176633 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

A five-gene signature derived from m6A regulators to improve prognosis prediction of neuroblastoma.
CONCLUSION: The five m6A regulatory genes identified in this study enable clinical prognosis of NB and may serve as novel therapeutic targets for NB. PMID: 32176634 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Integrative analyses of molecular pathways and key candidate biomarkers associated with colorectal cancer.
CONCLUSIONS: Our results provide in silico evidence for candidate biomolecules that may have strong biomarker potential for CRC-related translational strategies. PMID: 32176635 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Identification of key long non-coding RNAs in gastric adenocarcinoma.
CONCLUSIONS: This study identifies key lncRNAs in gastric adenocarcinoma which provides clues for exploring the pathogenesis and developing potential biomarkers for gastric adenocarcinoma. PMID: 32176636 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 18, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Identification of hub genes and pathways in cholangiocarcinoma by coexpression analysis.
CONCLUSIONS: Overall, this study identified 10 hub genes and cell cycle-related pathways were closely related to CCA development, progression and prognosis, which may contribute to CCA diagnosis and treatment. PMID: 32116234 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 3, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

An increased level of MiR-222-3p is associated with TMP2 suppression, ERK activation and is associated with metastasis and a poor prognosis in renal clear cell carcinoma.
CONCLUSION: Collectively, we showed that miR-222-3p functioned as a tumor progression marker and could be a target for future drug development. PMID: 32116235 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 3, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

MiR-30a suppresses metastasis of gastric adenocarcinoma via targeting FAP α.
CONCLUSION: MiR-30a inhibited gastric cancer metastasis by targeting FAPα, suggesting that miR-30a may function as a novel tumor suppressor in gastric cancer. PMID: 32116236 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - March 3, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Loss of SMARCB1 expression in colon carcinoma.
Authors: Melloul S, Mosnier JF, Masliah-Planchon J, Lepage C, Le Malicot K, Gornet JM, Edeline J, Dansette D, Texereau P, Delattre O, Laurent Puig P, Taieb J, J-F E Abstract SMARCB1 is a tumor suppressor gene, which is part of SWI/SNF complex involved in transcriptional regulation. Recently, loss of SMARCB1 expression has been reported in gastrointestinal carcinomas. Our purpose was to evaluate the incidence and prognostic value of SMARCB1 loss in colon carcinoma (CC). Patients with stage III CC (n= 1695), and a second cohort of 23 patients with poorly differentiated CC were analyzed. Immunohistochemistry for SMARC...
Source: Cancer Biomarkers - February 22, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

The role of vesicular overexpressed in cancer pro-survival protein 1 in hepatocellular carcinoma proliferation.
CONCLUSION: The present data indicate that VOPP1 may play an important role in the progression of HCC by targeting the MAPK and mTOR signalling pathways, and that VOPP1 may potentially be a candidate as a novel molecular target for HCC therapy. PMID: 32083568 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - February 22, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Identification of a novel microRNA profile including miR-106b, miR-17, miR-20b, miR-18a and miR-93 in the metastasis of nasopharyngeal carcinoma.
CONCLUSION: The present study revealed that five miRNAs (miR-106b, miR-17, miR-20b, miR-18a and miR-93) and several hub genes such as PTEN, KAT2B, CCND1, STAT3, and MAP3K5, might play critical roles in the development of NPC metastasis. Future investigations are needed to confirm the results. PMID: 32083569 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - February 22, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Evaluation of paraneoplastic antigens reveals TRIM21 autoantibodies as biomarker for early detection of ovarian cancer in combination with autoantibodies to NY-ESO-1 and TP53.
CONCLUSIONS: Autoantibodies to TRIM21, NY-ESO-1, and TP53 may complement CA125 in screening of women at genetic risk for ovarian cancer. PMID: 32083570 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - February 22, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Survival prediction for patients with lung adenocarcinoma: A prognostic risk model based on gene mutations.
CONCLUSIONS: We established a prognostic model for lung adenocarcinoma, and further concluded that SMARCA4, GNAS and TSC2 were a gene signature which plays a prognostic role. PMID: 32083571 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - February 22, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Low OCEL1 expression is associated with poor prognosis in human non-small cell lung cancer.
CONCLUSIONS: These results indicated that OCEL1 protein may serve as a novel prognostic biomarker in NSCLC. PMID: 32083572 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - February 22, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Identifying prognostic biomarkers of non-small cell lung cancer by transcriptome analysis.
CONCLUSIONS: We strictly determined prognostic genes of NSCLC, which would contribute to its carcinogenesis investigation and therapeutic methods improvement. PMID: 32083573 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - February 22, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Co-expression network analysis identified atypical chemokine receptor 1 (ACKR1) association with lymph node metastasis and prognosis in cervical cancer.
This study showed hub functional terms and gene participated in CC and then speculated that ACKR1 might be tumor suppressor for CC. PMID: 32083574 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - February 22, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Discovery of potential serum and urine-based microRNA as minimally-invasive biomarkers for breast and gynecological cancer.
CONCLUSIONS: Promising miRNAs as liquid biopsy-based tools in the detection of BC, EC and OC qualified for external validation in larger cohorts. PMID: 32083575 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - February 22, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Low serum exosomal miR-484 expression predicts unfavorable prognosis in ovarian cancer.
CONCLUSIONS: Collectively, serum exosomal miR-484 could serve as a reliable and non-invasive marker for predicting the prognosis of OC. PMID: 32065786 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - February 20, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Novel somatic alterations underlie Chinese papillary thyroid carcinoma.
Authors: Yang C, Xu W, Gong J, Liu Z, Cui D Abstract To characterize the somatic alterations of papillary thyroid carcinomas (PTC) in Chinese patients, we performed the next-generation-sequencing (NGS) study of the tumor-normal pairs of DNA and RNA samples extracted from 16 Chinese PTC patients. The whole genome sequencing (WGS) and transcriptome sequencing (RNA-seq) were conducted for 6 patients who were either current or former smokers and the whole exome sequencing (WES) and RNA-seq were conducted for another 10 patients who were never smokers. The NGS data were analyzed to identify somatic alteration events tha...
Source: Cancer Biomarkers - February 20, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Circulating Epstein-Barr virus microRNA profile reveals novel biomarker for nasopharyngeal carcinoma diagnosis.
In conclusion, we identified a novel biomarker - plasma miR-BART19-3p for the detection of NPC. PMID: 31958073 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - January 22, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research