Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response
Cancer Biomark. 2023 Nov 15. doi: 10.3233/CBM-220222. Online ahead of print.ABSTRACTBACKGROUND: Despite advances in lung cancer treatment, most lung cancers are diagnosed at an advanced stage. Expression of microRNA10b (miR-10b) and fibrinolytic activity, as reflected by soluble urokinase-type plasminogen activator receptor (suPAR) and plasminogen activator inhibitor 1 (PAI-1), are promising biomarker candidates.OBJECTIVE: To assess the expression of miR-10b, and serum levels of suPAR and PAI-1 in advanced stage non-small cell lung cancer (NSCLC) patients, and their correlation with progression, treatment response and prog...
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Lyana Setiawan Rahajuningsih Setiabudy Siti Boedina Kresno Noorwati Sutandyo Elisna Syahruddin Frederica Jovianti Siti Nadliroh Sofia Mubarika Rianto Setiabudy Nurjati C Siregar Source Type: research
Upregulation of MED7 was associated with progression in hepatocellular carcinoma
CONCLUSION: MED7 was upregulated in HCC and correlated with progression of HCC. Meanwhile, MED7 may promote HCC through participating in multiple gene networks to influence tumorigenesis as well as immune response in HCC microenvironment.PMID:38073375 | DOI:10.3233/CBM-220439 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Zheng-Lin Chen Ying-Yu Ma Xiao-Zhou Mou Jun-Gang Zhang Source Type: research
Assessing the clinical utility of biomarkers using the intervention probability curve (IPC)
CONCLUSIONS: The IPC methodology can be a valuable tool for assessing biomarkers prior to clinical implementation.PMID:38073376 | DOI:10.3233/CBM-230054 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Rafael Paez Dianna J Rowe Stephen A Deppen Eric L Grogan Alexander Kaizer Darryl J Bornhop Amanda K Kussrow Anna E Bar ón Fabien Maldonado Michael N Kammer Source Type: research
A comprehensive analysis of mRNA expression profiles of Esophageal Squamous Cell Carcinoma reveals downregulation of Desmoglein 1 and crucial genomic targets
CONCLUSION: We identified novel perturbed genes in relation to ESCC and explored their interaction network. DSG1 is one such gene, its association with microbiota and a clinical presentation seen commonly with ESCC hints that it is a good candidate for early diagnostic marker. Besides, in this study we highlight candidate genes and their molecular connections to risk factors, biological pathways, drug chemicals, and the survival probability of ESCC patients.PMID:38073377 | DOI:10.3233/CBM-230145 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Amal Alotaibi Veerendra P Gadekar Pranav Swaroop Gundla Sumana Mandarthi Subramanyeshwari Ravi Dhyeya Mallya Asna Tungekar B V Lavanya Ashok Kumar Bhagavath MaryAnne Wong Cordero Janne Pitkaniemi Raviraja N Seetharam Asmatanzeem Bepari Prashantha Hebbar Source Type: research
A new immune-related gene signature predicts the prognosis and immune escape of bladder cancer
CONCLUSIONS: These evidences revealed the vital role of IRGs in predicting prognosis, TP53 mutation and immune escape in BC patients.PMID:38073378 | DOI:10.3233/CBM-230190 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Yang Liu Yan-Song Han Jin-Feng Wang Zhong-Qi Pang Jian-She Wang Lu Zhang Jia-Xin He Lin-Kun Shen Bo Ji Bei-Chen Ding Ming-Hua Ren Source Type: research
Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma
CONCLUSION: mRNA expression of TROP-2, SPL-2, and CXCL12 among PTC cases increased in larger tumor size, tumor stages III and IV, and LN metastasis. Moreover, there was an increase in CXCL-12 gene expression among PTC cases with extra-thyroid extension. Thus, TROP-2, SPL-2, and CXCL12 expressions could be possible diagnostic and prognostic markers in PTC.PMID:38073379 | DOI:10.3233/CBM-230230 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Amany Selim Attia Samia Hussein Hend Sameh Amr Khalil Ahmad Barakat Waley Ihab Matar Reham Sameh Source Type: research
Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response
Cancer Biomark. 2023 Nov 15. doi: 10.3233/CBM-220222. Online ahead of print.ABSTRACTBACKGROUND: Despite advances in lung cancer treatment, most lung cancers are diagnosed at an advanced stage. Expression of microRNA10b (miR-10b) and fibrinolytic activity, as reflected by soluble urokinase-type plasminogen activator receptor (suPAR) and plasminogen activator inhibitor 1 (PAI-1), are promising biomarker candidates.OBJECTIVE: To assess the expression of miR-10b, and serum levels of suPAR and PAI-1 in advanced stage non-small cell lung cancer (NSCLC) patients, and their correlation with progression, treatment response and prog...
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Lyana Setiawan Rahajuningsih Setiabudy Siti Boedina Kresno Noorwati Sutandyo Elisna Syahruddin Frederica Jovianti Siti Nadliroh Sofia Mubarika Rianto Setiabudy Nurjati C Siregar Source Type: research
Upregulation of MED7 was associated with progression in hepatocellular carcinoma
CONCLUSION: MED7 was upregulated in HCC and correlated with progression of HCC. Meanwhile, MED7 may promote HCC through participating in multiple gene networks to influence tumorigenesis as well as immune response in HCC microenvironment.PMID:38073375 | DOI:10.3233/CBM-220439 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Zheng-Lin Chen Ying-Yu Ma Xiao-Zhou Mou Jun-Gang Zhang Source Type: research
Assessing the clinical utility of biomarkers using the intervention probability curve (IPC)
CONCLUSIONS: The IPC methodology can be a valuable tool for assessing biomarkers prior to clinical implementation.PMID:38073376 | DOI:10.3233/CBM-230054 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Rafael Paez Dianna J Rowe Stephen A Deppen Eric L Grogan Alexander Kaizer Darryl J Bornhop Amanda K Kussrow Anna E Bar ón Fabien Maldonado Michael N Kammer Source Type: research
A comprehensive analysis of mRNA expression profiles of Esophageal Squamous Cell Carcinoma reveals downregulation of Desmoglein 1 and crucial genomic targets
CONCLUSION: We identified novel perturbed genes in relation to ESCC and explored their interaction network. DSG1 is one such gene, its association with microbiota and a clinical presentation seen commonly with ESCC hints that it is a good candidate for early diagnostic marker. Besides, in this study we highlight candidate genes and their molecular connections to risk factors, biological pathways, drug chemicals, and the survival probability of ESCC patients.PMID:38073377 | DOI:10.3233/CBM-230145 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Amal Alotaibi Veerendra P Gadekar Pranav Swaroop Gundla Sumana Mandarthi Subramanyeshwari Ravi Dhyeya Mallya Asna Tungekar B V Lavanya Ashok Kumar Bhagavath MaryAnne Wong Cordero Janne Pitkaniemi Raviraja N Seetharam Asmatanzeem Bepari Prashantha Hebbar Source Type: research
A new immune-related gene signature predicts the prognosis and immune escape of bladder cancer
CONCLUSIONS: These evidences revealed the vital role of IRGs in predicting prognosis, TP53 mutation and immune escape in BC patients.PMID:38073378 | DOI:10.3233/CBM-230190 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Yang Liu Yan-Song Han Jin-Feng Wang Zhong-Qi Pang Jian-She Wang Lu Zhang Jia-Xin He Lin-Kun Shen Bo Ji Bei-Chen Ding Ming-Hua Ren Source Type: research
Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma
CONCLUSION: mRNA expression of TROP-2, SPL-2, and CXCL12 among PTC cases increased in larger tumor size, tumor stages III and IV, and LN metastasis. Moreover, there was an increase in CXCL-12 gene expression among PTC cases with extra-thyroid extension. Thus, TROP-2, SPL-2, and CXCL12 expressions could be possible diagnostic and prognostic markers in PTC.PMID:38073379 | DOI:10.3233/CBM-230230 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Amany Selim Attia Samia Hussein Hend Sameh Amr Khalil Ahmad Barakat Waley Ihab Matar Reham Sameh Source Type: research
Evaluation of hsa_circ_0000018/let-7f-5p/ FAM96A axis in lung adenocarcinoma progression
CONCLUSION: Our data reveal hsa_circ_0000018 as a tumor suppressor in LA that targets the let-7f-5p/FAM96A axis. Our findings enrich the known regulatory network of circRNAs in LA.PMID:38043005 | DOI:10.3233/CBM-230111 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 3, 2023 Category: Cancer & Oncology Authors: Qi Li Min Zhao Dan-Dan Hu Jun-Jiao Qin Wei He Source Type: research
Elevated expression patterns of P-element Induced Wimpy Testis (PIWI) transcripts are potential candidate markers for Hepatocellular Carcinoma
CONCLUSION: PIWIL mRNAs are overexpressed in HCC tissue and serum samples, the expression patterns could be valuable molecular markers for HCC, due to their association with age, tumour grade and pattern. To the best of our knowledge, our study is the first to report the expression levels of all PIWIL mRNA and to suggest their remarkable values as diagnostic and prognostic biomarkers, in addition to their correlation to HCC development. Additionally, a therapeutic opportunity might be also suggested through in silico miRNA prediction for HCC and PIWIL genes through DDX4 and miR-124-3p.PMID:38043006 | DOI:10.3233/CBM-230134...
Source: Cancer Biomarkers - December 3, 2023 Category: Cancer & Oncology Authors: Gehan Hammad Samah Mamdouh Dina Mohamed Seoudi Mohamed Ismail Seleem Gehan Safwat Rania Hassan Mohamed Source Type: research
Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model
CONCLUSION: Subcutaneous fat index could predict bone metastasis in BC patients. Deep learning multimodal algorithm demonstrates superior performance in assessing bone metastases in BC patients.PMID:38043007 | DOI:10.3233/CBM-230219 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 3, 2023 Category: Cancer & Oncology Authors: Shidi Miao Haobo Jia Wenjuan Huang Ke Cheng Wenjin Zhou Ruitao Wang Source Type: research
