Liquid biopsy in clinical outcomes and detection of T790M mutation in metastatic non-small cell lung cancer after progression to EGFR-TKI
CONCLUSIONS: Our findings showed that LB positivity was associated with worse survival outcomes and specific clinical characteristics. This study also confirmed the feasibility and detection rate of T790M mutation in a Latin American population.PMID:38108344 | DOI:10.3233/CBM-230124 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 18, 2023 Category: Cancer & Oncology Authors: David Heredia Laura Bola ño-Guerra Angel Valencia-Velarde Edgar Varela Santoyo Luis Lara-Mej ía Daniela C árdenas-Fernández Mario Orozco Graciela Cruz-Rico Oscar Arrieta Source Type: research
Construct dysregulated miRNA-mRNA interaction networks to conjecture possible pathogenesis for Stomach adenocarcinomas
CONCLUSION: This study established a miRNA-mRNA network via bioinformatic analysis and experiment validation for STAD.PMID:38108345 | DOI:10.3233/CBM-230125 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 18, 2023 Category: Cancer & Oncology Authors: Shuang Peng Hao Zhang Guoxin Song Jingfeng Zhu Shiyu Zhang Cheng Liu Feng Gao Hang Yang Wei Zhu Source Type: research
Serum aspartate aminotransferase, a novel potential biomarker of prognosis in extranodal natural killer/T cell lymphoma, nasal type
CONCLUSION: AST might represent a significant prognostic marker for ENKTL patients.PMID:38108343 | DOI:10.3233/CBM-230068 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 18, 2023 Category: Cancer & Oncology Authors: Ningning Yao Qing Hou Yu Liang Xin Cao Bochen Sun Lijuan Wei Ruifang Sun Jianzhong Cao Source Type: research
Liquid biopsy in clinical outcomes and detection of T790M mutation in metastatic non-small cell lung cancer after progression to EGFR-TKI
CONCLUSIONS: Our findings showed that LB positivity was associated with worse survival outcomes and specific clinical characteristics. This study also confirmed the feasibility and detection rate of T790M mutation in a Latin American population.PMID:38108344 | DOI:10.3233/CBM-230124 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 18, 2023 Category: Cancer & Oncology Authors: David Heredia Laura Bola ño-Guerra Angel Valencia-Velarde Edgar Varela Santoyo Luis Lara-Mej ía Daniela C árdenas-Fernández Mario Orozco Graciela Cruz-Rico Oscar Arrieta Source Type: research
Construct dysregulated miRNA-mRNA interaction networks to conjecture possible pathogenesis for Stomach adenocarcinomas
CONCLUSION: This study established a miRNA-mRNA network via bioinformatic analysis and experiment validation for STAD.PMID:38108345 | DOI:10.3233/CBM-230125 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 18, 2023 Category: Cancer & Oncology Authors: Shuang Peng Hao Zhang Guoxin Song Jingfeng Zhu Shiyu Zhang Cheng Liu Feng Gao Hang Yang Wei Zhu Source Type: research
Serum aspartate aminotransferase, a novel potential biomarker of prognosis in extranodal natural killer/T cell lymphoma, nasal type
CONCLUSION: AST might represent a significant prognostic marker for ENKTL patients.PMID:38108343 | DOI:10.3233/CBM-230068 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 18, 2023 Category: Cancer & Oncology Authors: Ningning Yao Qing Hou Yu Liang Xin Cao Bochen Sun Lijuan Wei Ruifang Sun Jianzhong Cao Source Type: research
Liquid biopsy in clinical outcomes and detection of T790M mutation in metastatic non-small cell lung cancer after progression to EGFR-TKI
CONCLUSIONS: Our findings showed that LB positivity was associated with worse survival outcomes and specific clinical characteristics. This study also confirmed the feasibility and detection rate of T790M mutation in a Latin American population.PMID:38108344 | DOI:10.3233/CBM-230124 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 18, 2023 Category: Cancer & Oncology Authors: David Heredia Laura Bola ño-Guerra Angel Valencia-Velarde Edgar Varela Santoyo Luis Lara-Mej ía Daniela C árdenas-Fernández Mario Orozco Graciela Cruz-Rico Oscar Arrieta Source Type: research
Construct dysregulated miRNA-mRNA interaction networks to conjecture possible pathogenesis for Stomach adenocarcinomas
CONCLUSION: This study established a miRNA-mRNA network via bioinformatic analysis and experiment validation for STAD.PMID:38108345 | DOI:10.3233/CBM-230125 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 18, 2023 Category: Cancer & Oncology Authors: Shuang Peng Hao Zhang Guoxin Song Jingfeng Zhu Shiyu Zhang Cheng Liu Feng Gao Hang Yang Wei Zhu Source Type: research
Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response
Cancer Biomark. 2023 Nov 15. doi: 10.3233/CBM-220222. Online ahead of print.ABSTRACTBACKGROUND: Despite advances in lung cancer treatment, most lung cancers are diagnosed at an advanced stage. Expression of microRNA10b (miR-10b) and fibrinolytic activity, as reflected by soluble urokinase-type plasminogen activator receptor (suPAR) and plasminogen activator inhibitor 1 (PAI-1), are promising biomarker candidates.OBJECTIVE: To assess the expression of miR-10b, and serum levels of suPAR and PAI-1 in advanced stage non-small cell lung cancer (NSCLC) patients, and their correlation with progression, treatment response and prog...
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Lyana Setiawan Rahajuningsih Setiabudy Siti Boedina Kresno Noorwati Sutandyo Elisna Syahruddin Frederica Jovianti Siti Nadliroh Sofia Mubarika Rianto Setiabudy Nurjati C Siregar Source Type: research
Upregulation of MED7 was associated with progression in hepatocellular carcinoma
CONCLUSION: MED7 was upregulated in HCC and correlated with progression of HCC. Meanwhile, MED7 may promote HCC through participating in multiple gene networks to influence tumorigenesis as well as immune response in HCC microenvironment.PMID:38073375 | DOI:10.3233/CBM-220439 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Zheng-Lin Chen Ying-Yu Ma Xiao-Zhou Mou Jun-Gang Zhang Source Type: research
Assessing the clinical utility of biomarkers using the intervention probability curve (IPC)
CONCLUSIONS: The IPC methodology can be a valuable tool for assessing biomarkers prior to clinical implementation.PMID:38073376 | DOI:10.3233/CBM-230054 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Rafael Paez Dianna J Rowe Stephen A Deppen Eric L Grogan Alexander Kaizer Darryl J Bornhop Amanda K Kussrow Anna E Bar ón Fabien Maldonado Michael N Kammer Source Type: research
A comprehensive analysis of mRNA expression profiles of Esophageal Squamous Cell Carcinoma reveals downregulation of Desmoglein 1 and crucial genomic targets
CONCLUSION: We identified novel perturbed genes in relation to ESCC and explored their interaction network. DSG1 is one such gene, its association with microbiota and a clinical presentation seen commonly with ESCC hints that it is a good candidate for early diagnostic marker. Besides, in this study we highlight candidate genes and their molecular connections to risk factors, biological pathways, drug chemicals, and the survival probability of ESCC patients.PMID:38073377 | DOI:10.3233/CBM-230145 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Amal Alotaibi Veerendra P Gadekar Pranav Swaroop Gundla Sumana Mandarthi Subramanyeshwari Ravi Dhyeya Mallya Asna Tungekar B V Lavanya Ashok Kumar Bhagavath MaryAnne Wong Cordero Janne Pitkaniemi Raviraja N Seetharam Asmatanzeem Bepari Prashantha Hebbar Source Type: research
A new immune-related gene signature predicts the prognosis and immune escape of bladder cancer
CONCLUSIONS: These evidences revealed the vital role of IRGs in predicting prognosis, TP53 mutation and immune escape in BC patients.PMID:38073378 | DOI:10.3233/CBM-230190 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Yang Liu Yan-Song Han Jin-Feng Wang Zhong-Qi Pang Jian-She Wang Lu Zhang Jia-Xin He Lin-Kun Shen Bo Ji Bei-Chen Ding Ming-Hua Ren Source Type: research
Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma
CONCLUSION: mRNA expression of TROP-2, SPL-2, and CXCL12 among PTC cases increased in larger tumor size, tumor stages III and IV, and LN metastasis. Moreover, there was an increase in CXCL-12 gene expression among PTC cases with extra-thyroid extension. Thus, TROP-2, SPL-2, and CXCL12 expressions could be possible diagnostic and prognostic markers in PTC.PMID:38073379 | DOI:10.3233/CBM-230230 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Amany Selim Attia Samia Hussein Hend Sameh Amr Khalil Ahmad Barakat Waley Ihab Matar Reham Sameh Source Type: research
Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response
Cancer Biomark. 2023 Nov 15. doi: 10.3233/CBM-220222. Online ahead of print.ABSTRACTBACKGROUND: Despite advances in lung cancer treatment, most lung cancers are diagnosed at an advanced stage. Expression of microRNA10b (miR-10b) and fibrinolytic activity, as reflected by soluble urokinase-type plasminogen activator receptor (suPAR) and plasminogen activator inhibitor 1 (PAI-1), are promising biomarker candidates.OBJECTIVE: To assess the expression of miR-10b, and serum levels of suPAR and PAI-1 in advanced stage non-small cell lung cancer (NSCLC) patients, and their correlation with progression, treatment response and prog...
Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Lyana Setiawan Rahajuningsih Setiabudy Siti Boedina Kresno Noorwati Sutandyo Elisna Syahruddin Frederica Jovianti Siti Nadliroh Sofia Mubarika Rianto Setiabudy Nurjati C Siregar Source Type: research
