A comprehensive analysis of mRNA expression profiles of Esophageal Squamous Cell Carcinoma reveals downregulation of Desmoglein 1  and crucial genomic targets

CONCLUSION: We identified novel perturbed genes in relation to ESCC and explored their interaction network. DSG1 is one such gene, its association with microbiota and a clinical presentation seen commonly with ESCC hints that it is a good candidate for early diagnostic marker. Besides, in this study we highlight candidate genes and their molecular connections to risk factors, biological pathways, drug chemicals, and the survival probability of ESCC patients.PMID:38073377 | DOI:10.3233/CBM-230145

Source: Cancer Biomarkers - December 11, 2023 Category: Cancer & Oncology Authors: Amal Alotaibi Veerendra P Gadekar Pranav Swaroop Gundla Sumana Mandarthi Subramanyeshwari Ravi Dhyeya Mallya Asna Tungekar B V Lavanya Ashok Kumar Bhagavath MaryAnne Wong Cordero Janne Pitkaniemi Raviraja N Seetharam Asmatanzeem Bepari Prashantha Hebbar Source Type: research