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Total 964 results found since Jan 2013.
LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE
Am J Physiol Lung Cell Mol Physiol. 2021 Aug 18. doi: 10.1152/ajplung.00138.2021. Online ahead of print.ABSTRACTThe receptor for advanced glycation end-products (RAGE) has been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, it is still unknown whether RAGE directly contributes to alveolar epithelial damage and abnormal repair responses. We hypothesize that RAGE activation not only induces lung tissue damage but also hampers alveolar epithelial repair responses. The effects of the RAGE ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild...
Source: Am J Physiol Lung Ce... - August 18, 2021 Category: Respiratory Medicine Authors: Simon D Pouwels Laura Hesse Xinhui Wu Venkata Sita Rama Raju Allam Daan van Oldeniel Linsey J Bhiekharie Simon Phipps Brian G G Oliver Reinoud Gosens Maria Sukkar Irene H Heijink Source Type: research
DCLK1 Inhibition Sensitizes Colorectal Cancer Cells to Radiation Treatment
Int J Mol Cell Med. 2021 Winter;10(1):23-33. doi: 10.22088/IJMCM.BUMS.10.1.23. Epub 2021 May 22.ABSTRACTColorectal cancer (CRC) is one of the most prevalent diagnosed cancers and a common cause of cancer-related mortality. Despite effective clinical responses, a large proportion of patients undergo resistance to radiation therapy. Therefore, the identification of efficient targeted therapy strategies would be beneficial to overcome cancer radioresistance. Doublecortin-like kinase 1 (DCLK1) is an intestinal and pancreatic stem cell marker that showed overexpression in a variety of cancers. The transfection of DCLK1 siRNA to...
Source: Molecular Medicine - July 16, 2021 Category: Molecular Biology Authors: Chiman Mohammadi Ali Mahdavinezhad Massoud Saidijam Fatemeh Bahreini Abdolazim Sedighi Pashaki Mohammad Hadi Gholami Rezvan Najafi Source Type: research
KMT2C is a potential biomarker of prognosis and chemotherapy sensitivity in breast cancer
CONCLUSION: We conclude that KMT2C could serve as a potential biomarker of prognosis and chemotherapy sensitivity by affecting the DNA damage repair-related genes of breast cancer.PMID:34240274 | DOI:10.1007/s10549-021-06325-1
Source: Cell Research - July 9, 2021 Category: Cytology Authors: Xinhua Liu Rongfang Qiu Min Xu Miaomiao Meng Siyu Zhao Jiansong Ji Yang Yang Source Type: research
Dual role of Fam208a during zygotic cleavage and early embryonic development
Exp Cell Res. 2021 Jun 30:112723. doi: 10.1016/j.yexcr.2021.112723. Online ahead of print.ABSTRACTMaintenance of genome stability is essential for every living cell as genetic information is repeatedly challenged during DNA replication in each cell division event. Errors, defects, delays, and mistakes that arise during mitosis or meiosis lead to an activation of DNA repair processes and in case of their failure, programmed cell death, i.e. apoptosis, could be initiated. Fam208a is a protein whose importance in heterochromatin maintenance has been described recently. In this work, we describe the crucial role of Fam208a in ...
Source: Experimental Cell Research - July 3, 2021 Category: Cytology Authors: Veronika Gresakova Vendula Novosadova Michaela Prochazkova Jan Prochazka Radislav Sedlacek Source Type: research
