Am J Physiol Lung Cell Mol Physiol; +27 new citations
27 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Lung Cell Mol Physiol These pubmed results were generated on 2019/11/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - November 14, 2019 Category: Respiratory Medicine Tags: Report Source Type: research

Lung Genotoxicity of Benzo(a)Pyrene in Vivo Involves Reactivation of LINE-1 Retrotransposon and Reprogramming ofOncogenic Regulatory Networks.
Abstract Several lines of evidence have implicated LINE-1 (Long INterspersed nuclear Element-1) retroelement in the onset and progression of lung cancer. Retrotransposition-dependent mechanisms leading to DNA mobilization give rise to insertion mutations and DNA deletions, while retrotransposition-independent mechanisms disrupt epithelial programming and differentiation. Previous work by our group established that tobacco carcinogens like benzo(a)pyrene (BaP) reactivate LINE-1 in bronchial epithelial cells through displacement of NuRD corepressor complexes and interference with retinoblastoma-regulated epigenetic ...
Source: Am J Physiol Lung Ce... - October 9, 2019 Category: Respiratory Medicine Authors: Hassanin AA, Tavera-Garcia M, Moorthy B, Zhang GD, Ramos KS Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Type 2 secretory cells are primary source of ATP release in mechanically-stretched lung alveolar cells.
Abstract Extracellular ATP and its metabolites are potent paracrine modulators of lung alveolar cell function, including surfactant secretion and fluid transport but the sources and mechanism of intra-alveolar ATP release remain unclear. To determine contribution of gas exchanging alveolar type 1 (AT1) and surfactant-secreting type 2 (AT2) cells to stretch-induced ATP release, we used quantitative real-time luminescence ATP imaging and rat primary alveolar cells cultured on silicon substrate for 2-7 days. When cultured on solid support primary AT2 cells progressively transdifferentiated into AT1-like cells with ~2...
Source: Am J Physiol Lung Ce... - October 9, 2019 Category: Respiratory Medicine Authors: Tan JJ, Boudreault F, Adam D, Brochiero E, Grygorczyk R Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Synchrotron-based phase contrast micro-CT as a tool for understanding pulmonary vascular pathobiology and the 3-D micro-anatomy of alveolar capillary dysplasia.
CONCLUSION: We demonstrate the advantages of using synchrotron-based phase contrast micro-CT for three-dimensional characterization of pulmonary microvascular anatomy in paraffin-embedded tissue. Vascular dye injections add additional value. We confirm intra-pulmonary shunting in ACD/MPV and provide support for the hypothesis that MPVs are dilated bronchial veins/venules. PMID: 31596108 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - October 9, 2019 Category: Respiratory Medicine Authors: Norvik CC, Westöö CK, Peruzzi N, Lovric G, van der Have O, Mokso R, Jeremiasen I, Brunnström H, Galambos C, Bech M, Tran-Lundmark K Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Swapping mitochondria: A key to understanding susceptibility to neonatal chronic lung disease.
PMID: 31596117 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - October 9, 2019 Category: Respiratory Medicine Authors: Dylag AM, Brookes PS, O'Reilly MA Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia.
The objective of this review is to present advances made in our understanding of the mechanisms of lung alveolarization and BPD over the period 01 January 2017 - 30 June 2019, a period that spans the 50th anniversary of the original clinical description of BPD in preterm infants. PMID: 31596603 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - October 9, 2019 Category: Respiratory Medicine Authors: Lignelli E, Palumbo F, Myti D, Morty RE Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

The Multiple Roles of Macrophage Migration Inhibitory Factor in Pulmonary Hypertension.
The objective of this review is to summarize the scientific evidence on the pathogenic roles of MIF and its potential as a biomarker and therapeutic target in PH/PAH. PMID: 31577159 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - October 2, 2019 Category: Respiratory Medicine Authors: Jalce G, Guignabert C Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Fritz Rohrer (1888-1926), a pioneer in pulmonary mechanics whose work was inexplicably ignored for about 30 years.
Abstract Fritz Rohrer (1888-1926) has a special place in the history of respiratory physiology for two reasons. The first is that he laid the foundations of modern pulmonary mechanics in the early 1900s. For example, his seminal paper on pulmonary dynamics, that is the pressure-flow relationships in the airways was published in 1915 in one of the top journals in the field. It included extensive measurements of airway dimensions in post-mortem human lungs and a sophisticated analysis of the modes of airflow. This was closely followed by a very original analysis of lung statics that included studies of airway pressu...
Source: Am J Physiol Lung Ce... - October 2, 2019 Category: Respiratory Medicine Authors: West JB Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Aneurysm-type Plexiform Lesions Form in Supernumerary Arteries in Pulmonary Arterial Hypertension: Potential Therapeutic Implications.
This study investigates the hypothesis that aneurysm-type plexiform lesions form in supernumerary arteries due to their anatomical properties and endothelial characteristics similar to PMVECs. To induce PAH, rats were injected with Sugen 5416, and exposed to hypoxia (10% O2) for 3 days (early-stage) or 3 weeks (mid-stage), or 3 weeks of hypoxia with an additional 10 weeks of normoxia (late-stage PAH). We examined morphology of pulmonary vasculature and vascular remodeling in lung serial sections from PAH and normal rats. Aneurysm-type plexiform lesions formed in small side branches of pulmonary arteries with morphological ...
Source: Am J Physiol Lung Ce... - October 2, 2019 Category: Respiratory Medicine Authors: Oshima K, Crockett ES, Joshi SR, McLendon JM, Matsumoto Y, McMurtry IF, Abe K, Oka M Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Lung Inflammatory Environments Differentially Alter Mesenchymal Stromal Cell Behavior.
Abstract Mesenchymal stromal (stem) cells (MSCs) are increasingly demonstrated to ameliorate experimentally-induced lung injuries through disease-specific anti-inflammatory actions, thus suggesting that different in vivo inflammatory environments can influence MSC actions. To determine the effects of different representative inflammatory lung conditions, human bone marrow-derived MSCs (hMSCs) were exposed to in vitro culture conditions from bronchoalveolar lavage fluid (BALF) samples obtained from patients with either the acute respiratory distress syndrome (ARDS) or with other lung diseases including acute respir...
Source: Am J Physiol Lung Ce... - September 25, 2019 Category: Respiratory Medicine Authors: Abreu SC, Enes SR, Dearborn J, Goodwin M, Coffey A, Borg ZD, Dos Santos CC, Wargo MJ, Cruz FF, Loi R, DeSarno M, Ashikaga T, Antunes MA, Rocco PRM, Liu KD, Lee JW, Matthay MA, McKenna DH, Weiss DJ Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

MicroRNA-mediated Downregulation of K+ Channels in Pulmonary Arterial Hypertension.
Abstract Downregulated expression of K+ channels and decreased K+ currents in pulmonary artery smooth muscle cells (PASMC) have been implicated in the development of sustained pulmonary vasoconstriction and vascular remodeling in patients with idiopathic pulmonary arterial hypertension (IPAH). However, it is unclear exactly how K+ channels are downregulated in IPAH-PASMC. MicroRNAs (miRNAs) are small noncoding RNAs that are capable of posttranscriptionally regulating gene expression by binding to the 3'-untranslated regions (3'-UTR) of their targeted mRNAs. Here we report that specific miRNAs are responsible for t...
Source: Am J Physiol Lung Ce... - September 25, 2019 Category: Respiratory Medicine Authors: Babicheva A, Ayon RJ, Zhao T, Ek Vitorin JF, Pohl NM, Yamamura A, Yamamura H, Quinton BA, Ba M, Wu L, Ravellette KS, Rahimi S, Balistrieri F, Harrington A, Vanderpool RR, Thistlethwaite PA, Makino A, Yuan JX Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

17 ß-estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner.
17ß-estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner. Am J Physiol Lung Cell Mol Physiol. 2019 Sep 25;: Authors: Fuentes N, Nicoleau M, Cabello N, Montes D, Zomorodi N, Chroneos ZC, Silveyra P Abstract Inflammatory lung diseases affect men and women disproportionately, suggesting that fluctuations of circulating hormone levels mediate inflammatory responses. Studies have shown that ozone exposure contributes to lung injury and impairment of innate immunity with differential effects in men and women. Here, we hypothesized that 17ß-estradiol ...
Source: Am J Physiol Lung Ce... - September 25, 2019 Category: Respiratory Medicine Authors: Fuentes N, Nicoleau M, Cabello N, Montes D, Zomorodi N, Chroneos ZC, Silveyra P Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD.
Abstract Cigarette smoking has marked effects on lung tissue, including induction of oxidative stress, inflammatory cell recruitment and a protease/anti-protease imbalance. These effects contribute to tissue remodeling and destruction resulting in loss of lung function in chronic obstructive pulmonary disease (COPD) patients. Cathepsin S (CatS) is a cysteine protease that is involved in the remodeling/degradation of connective tissue and basement membrane. Aberrant expression or activity of CatS has been implicated in a variety of diseases, including arthritis, cancer, cardiovascular and lung diseases. However, li...
Source: Am J Physiol Lung Ce... - September 25, 2019 Category: Respiratory Medicine Authors: Andrault PM, Schamberger AC, Chazeirat T, Sizaret D, Renault J, Staab-Weijnitz CA, Hennen E, Petit-Courty A, Wartenberg M, Saidi A, Baranek T, Guyetant S, Courty Y, Eickelberg O, Lalmanach G, Lecaille F Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Laminin α4 contributes to airway remodeling and inflammation in asthma.
This study for the first time indicates a prominent role for laminin α4 in ASM function and in inflammation, AHR and remodeling in asthma, whereas the role of laminin α5 is more subtle. PMID: 31553662 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - September 25, 2019 Category: Respiratory Medicine Authors: Prabhala P, Wright DB, Robbe P, Bitter C, Pera T, Ten Hacken NHT, van den Berg M, Timens W, Meurs H, Dekkers BGJ Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Pulmonary inflammation induced by low dose particulate matter exposure in mice.
PMID: 31530166 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - September 18, 2019 Category: Respiratory Medicine Authors: Schuliga M, Bartlett NW Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Anti-viral immunity is impaired in COPD patients with frequent exacerbations.
Abstract Patients with frequent exacerbations represent a chronic obstructive pulmonary disease (COPD) sub-group requiring better treatment options. The aim of this study was to determine the innate immune mechanisms that underlie susceptibility to frequent exacerbations in COPD. We measured sputum expression of immune mediators and bacterial loads in samples from patients with COPD at stable state and during virus-associated exacerbations. In vitro immune responses to rhinovirus infection in differentiated primary bronchial epithelial cells (BECs) sampled from patients with COPD were additionally evaluated. Patie...
Source: Am J Physiol Lung Ce... - September 12, 2019 Category: Respiratory Medicine Authors: Singanayagam A, Loo SL, Calderazzo MA, Finney LJ, Trujillo Torralbo MB, Bakhsoliani E, Girkin J, Veerati PC, Pathinayake PS, Nichol KS, Reid AT, Footitt J, Johnston SL, Bartlett NW, Mallia P Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Characterization of Cystic Fibrosis Airway Smooth Muscle Cell Proliferative and Contractile Activities.
In this study, the contractile and proliferative properties of ASM cells isolated from healthy donor and CF transplant lungs were compared. Proliferation assays showed CF ASM proliferate at a higher rate than healthy cells. Through calcium analysis, no differences in contractile activation was found, however, CF ASM lagged in their reuptake of calcium. The combination CFTR corrector and potentiator, VX-809/770, was used to restore proper CFTR function in CF ASM which resulted in a reduction in proliferation and in a normalization of calcium reuptake kinetics. These results show that improper CFTR function in ASM cause intr...
Source: Am J Physiol Lung Ce... - September 11, 2019 Category: Respiratory Medicine Authors: Jang JH, Panariti A, O'Sullivan MJ, Pyrch M, Wong C, Lauzon AM, Martin JG Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Editorial Focus on: "Mechanisms of Moderate Hypoxia Effects on Developing Human Lung Fibroblasts".
Editorial Focus on: "Mechanisms of Moderate Hypoxia Effects on Developing Human Lung Fibroblasts". Am J Physiol Lung Cell Mol Physiol. 2019 Sep 11;: Authors: Sucre JMS, Plosa EJ PMID: 31508975 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - September 11, 2019 Category: Respiratory Medicine Authors: Sucre JMS, Plosa EJ Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Volume-CLEM: A Method for Correlative Light- and Electron-Microscopy in Three Dimensions.
d C Abstract Generation of 3D datasets from serial sections of tissues imaged by light microscopy (LM) allows identification of rare structures by morphology or fluorescent labeling. Here, we demonstrate a workflow for correlative light- and electron microscopy (EM) from three-dimensional (3D) LM to 3D EM, using the same sectioned material for both methods consecutively. The new approach is easy to reproduce in routine EM laboratories and applicable to a wide range of organs and research questions. PMID: 31508976 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - September 11, 2019 Category: Respiratory Medicine Authors: Hegermann J, Wrede C, Fassbender S, Schliep R, Ochs M, Knudsen L, Mühlfeld C Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Editorial Focus on: "Role of TRPP2 in Mouse Airway Smooth Muscle Tension and Respiration".
Editorial Focus on: "Role of TRPP2 in Mouse Airway Smooth Muscle Tension and Respiration". Am J Physiol Lung Cell Mol Physiol. 2019 Sep 11;: Authors: Mercado-Perez A, Beyder A PMID: 31508977 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - September 11, 2019 Category: Respiratory Medicine Authors: Mercado-Perez A, Beyder A Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Reliably Sourced Airway Mucus.
PMID: 31508979 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - September 11, 2019 Category: Respiratory Medicine Authors: Joyner K, Duncan GA Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Editorial Focus on: "Surfactant Protein-D Modulation of Pulmonary Macrophage Phenotype is Controlled by S-Nitrosylation".
Editorial Focus on: "Surfactant Protein-D Modulation of Pulmonary Macrophage Phenotype is Controlled by S-Nitrosylation". Am J Physiol Lung Cell Mol Physiol. 2019 Sep 11;: Authors: Allawzi A, Nozik-Grayck E PMID: 31508980 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - September 11, 2019 Category: Respiratory Medicine Authors: Allawzi A, Nozik-Grayck E Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

A multi-omics zoom on the molecular networks of Lung development.
PMID: 31508981 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - September 11, 2019 Category: Respiratory Medicine Authors: Clair GC Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection.
Abstract Ataxia-telangiectasia (A-T) is a neurodegenerative disorder affecting approximately 1 in 40,000 to 100,000 children caused by mutations in the A-T mutated(ATM) gene. Recurrent respiratory infections are a common and challenging co-morbidity often leading to the development of bronchiectasis in A-T individuals. The role of ATM in development of immune memory in response to recurrent respiratory viral infections is not well understood. Here, we infect wildtype (WT) and Atm-null mice with influenza A virus (IAV; HKx31, H3N2) and interrogate the immune memory with secondary infections designed to challenge th...
Source: Am J Physiol Lung Ce... - September 11, 2019 Category: Respiratory Medicine Authors: Warren R, Domm W, Yee M, Campbell A, Malone J, Wright T, Mayer-Proschel M, O'Reilly MA Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Clinically Relevant Model of Pneumococcal Pneumonia, ARDS, and Non-Pulmonary Organ Dysfunction in Mice.
Abstract Pneumonia is responsible for more deaths in the United States than any other infectious disease. Severe pneumonia is a common cause of acute respiratory failure and the Acute Respiratory Distress Syndrome (ARDS). Despite the introduction of effective antibiotics and intensive supportive care in the 20th century, death rates from community acquired pneumonia among ICU patients remain as high as 35%. Beyond antimicrobial treatment, no targeted molecular therapies have yet proven effective, highlighting the need for additional research. Despite some limitations, small animal models of pneumonia and the mecha...
Source: Am J Physiol Lung Ce... - September 11, 2019 Category: Respiratory Medicine Authors: Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Bnip3 Regulates Airway Smooth Muscle Cell Focal Adhesion and Proliferation.
This study reveals a novel role for Bnip3 in ASM functions and establishes Bnip3 as a potential target in mitigating ASM remodeling in asthma. PMID: 31509440 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - September 11, 2019 Category: Respiratory Medicine Authors: Pan S, Shah SD, Panettieri RA, Deshpande DA Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Am J Physiol Lung Cell Mol Physiol; +16 new citations
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Lung Cell Mol Physiol These pubmed results were generated on 2019/09/08PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - September 8, 2019 Category: Respiratory Medicine Tags: Report Source Type: research

Am J Physiol Lung Cell Mol Physiol; +20 new citations
20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Lung Cell Mol Physiol These pubmed results were generated on 2019/08/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - August 23, 2019 Category: Respiratory Medicine Tags: Report Source Type: research

Early Studies on the Surface Epithelium of Mammalian Airways.
This article traces the beginnings of the various areas of physiological research on airway epithelium. First mentioned in 1602, it was not until 1834 that it was found to be ciliated. Goblet and basal cells were described in 1852 to be followed by about 10 other epithelial cell types (the most recent in 2018). It also contains nerve endings and resident leukocytes. Mucociliary clearance was documented in 1835, but the first studies on the ciliary beat cycle did not appear until 1890, and a definitive description was not published until 1981. It was established in 1932 that goblet cells in the cat trachea were unresponsive...
Source: Am J Physiol Lung Ce... - July 17, 2019 Category: Respiratory Medicine Authors: Widdicombe JH Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

The role of DJ-1 in human primary alveolar type II cell injury induced by e-cigarette aerosol.
Abstract The alveolus participates in gas exchange, which can be impaired by environmental factors and toxins. There is an increase in using electronic cigarettes (e-cigarettes); however, their effect on human primary alveolar epithelial cells is unknown. Human lungs were obtained from non-smoker organ donors to isolate alveolar type II (ATII) cells. ATII cells produce and secrete pulmonary surfactant, restore the epithelium after damage and their metabolism highly depends on mitochondrial function. Our data indicates that human ATII cell exposure to e-cigarette aerosol increased IL-8 levels and induced DNA damage...
Source: Am J Physiol Lung Ce... - July 17, 2019 Category: Respiratory Medicine Authors: Bahmed K, Lin CR, Simborio H, Karim L, Aksoy M, Kelsen S, Tomar D, Muniswamy M, Elrod JW, Messier E, Mason RJ, Unterwald EM, Eisenstein TK, Criner GJ, Kosmider B Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Analysis of biological networks in the endothelium with biomimetic microsystem platform.
Abstract Here we describe a novel method for studying the protein "interactome" in primary human cells and applied this method to investigate the effect of post translational protein modifications (PTMs) on the protein's functions. We created a novel "biomimetic microsystem platform" (Bio-MSP) to isolate the protein complexes in primary cells by covalently attaching purified His-tagged proteins to a solid microscale support. Using this Bio-MSP we have analyzed the "interactomes" of unphosphorylated and phosphomimetic End Binding protein 3 (EB3) in endothelial cells. Pathway analysis o...
Source: Am J Physiol Lung Ce... - July 17, 2019 Category: Respiratory Medicine Authors: Kruse K, Klomp J, Sun M, Chen Z, Santana D, Huang F, Kanabar P, Maienschein-Cline M, Komarova YA Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

The relationship between DJ-1 and S100A8 in human primary alveolar type II cells in emphysema.
Abstract Pulmonary emphysema is characterized by alveolar type II (ATII) cell death, destruction of alveolar wall septa, and irreversible airflow limitation. Cigarette smoke induces oxidative stress and is the main risk factor for this disease development. ATII cells isolated from non-smokers, smokers, and patients with emphysema were used for this study. High apoptosis was detected in ATII cells obtained from individuals with this disease. DJ-1 and S100A8 have cytoprotective functions against oxidative stress-induced cell injury. Reduced DJ-1 and S100A8 interaction was found in ATII cells in patients with emphyse...
Source: Am J Physiol Lung Ce... - July 17, 2019 Category: Respiratory Medicine Authors: Lin CR, Bahmed K, Tomar D, Marchetti N, Criner GJ, Bolla S, Wilson MA, Madesh M, Kosmider B Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Am J Physiol Lung Cell Mol Physiol; +41 new citations
41 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Lung Cell Mol Physiol These pubmed results were generated on 2019/07/04PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - July 4, 2019 Category: Respiratory Medicine Tags: Report Source Type: research

Am J Physiol Lung Cell Mol Physiol; +18 new citations
18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Lung Cell Mol Physiol These pubmed results were generated on 2019/07/03PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - July 3, 2019 Category: Respiratory Medicine Tags: Report Source Type: research

Distinct pathways to the parafacial respiratory group to trigger active expiration in adult rats.
Abstract Active expiration (AE) is part of the breathing phase; it is conditional and occurs when we increase our metabolic demand, such as during hypercapnia, hypoxia or exercise. The parafacial respiratory group (pFRG) is involved in AE. Data from the literature suggest that excitatory and the absence of inhibitory inputs to the pFRG are necessary to determine AE. However, the source of the inputs to the pFRG that trigger AE remains unclear. We show in adult urethane-anesthetized Wistar rats that the pharmacological inhibition of the medial aspect of the nucleus of the solitary tract (mNTS) or the rostral aspect...
Source: Am J Physiol Lung Ce... - June 26, 2019 Category: Respiratory Medicine Authors: Silva JN, Oliveira LM, Souza FC, Moreira TS, Takakura AC Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Interdependence of hypoxia and β-adrenergic receptor signaling in Pulmonary Arterial Hypertension.
Interdependence of hypoxia and β-adrenergic receptor signaling in Pulmonary Arterial Hypertension. Am J Physiol Lung Cell Mol Physiol. 2019 Jun 26;: Authors: Stephens OR, Weiss K, Frimel M, Rose JA, Sun Y, Asosingh K, Farha S, Highland KB, Naga Prasad SV, Erzurum SC Abstract The β-adrenergic receptor (βAR) exists in an equilibrium of inactive and active conformational states, which shifts in response to different ligands and results in downstream signaling. In addition to cAMP, βAR signals to hypoxia-inducible factor 1 (HIF-1). We hypothesized that a βAR active conformation (R...
Source: Am J Physiol Lung Ce... - June 26, 2019 Category: Respiratory Medicine Authors: Stephens OR, Weiss K, Frimel M, Rose JA, Sun Y, Asosingh K, Farha S, Highland KB, Naga Prasad SV, Erzurum SC Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Pulmonary capillary surface area in supine exercising humans: demonstration of vascular recruitment.
Abstract In exercising humans, cardiac output (CO) increases, with minor increases in pulmonary artery pressure (PAP). It is unknown if the CO is accommodated via distention of already perfused capillaries or via recruitment of non-concomitantly perfused pulmonary capillaries. Ten subjects (9 female) performed symptom-limited exercise. Six had resting mean PAP (PAPm)
Source: Am J Physiol Lung Ce... - June 26, 2019 Category: Respiratory Medicine Authors: Langleben D, Orfanos SE, Giovinazzo M, Schlesinger RD, Naeije R, Fox BD, Abualsaud AO, Blenkhorn F, Rudski LG, Catravas JD Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Ghrelin attenuates sepsis-induced acute lung injury by inhibiting the NF- κB, iNOS, and Akt signaling in alveolar macrophages.
In conclusion, ghrelin exerts a protective role against sepsis-induced ALI probably by reducing the production of inflammatory cytokines from AMs via inhibition of NF-κB-iNOS pathway or Akt signaling. PMID: 31242025 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - June 26, 2019 Category: Respiratory Medicine Authors: Zheng H, Liang W, He W, Huang C, Chen Q, Yi H, Long L, Deng Y, Zeng M Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Extrinsic acidosis suppresses glycolysis and migration while increasing network formation in pulmonary microvascular endothelial cells.
Abstract Acidosis is common among critically ill patients, but current approaches to correct pH do not improve disease outcomes. During systemic acidosis, cells are either passively exposed to extracellular acidosis that other cells have generated (extrinsic acidosis) or they are exposed to acid which they generate and export into the extracellular space (intrinsic acidosis). Although endothelial repair following intrinsic acidosis has been studied, the impact of extrinsic acidosis on migration and angiogenesis is unclear. We hypothesized that extrinsic acidosis inhibits metabolism and migration but promotes capil...
Source: Am J Physiol Lung Ce... - May 1, 2019 Category: Respiratory Medicine Authors: Lee JY, Onanyan M, Garrison I, White R, Crook M, Alexeyev MF, Kozhukhar N, Pastukh V, Swenson ER, Supuran CT, Stevens T Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Acute exposure to e-cigarettes causes inflammation and endothelial oxidative stress in non-smoking healthy young subjects.
Abstract The effects of e-cigarette (e-cig) aerosol inhalation by nonsmokers have not been examined to date. The present study was designed to evaluate the acute response to aerosol inhalation of non nicotinized e-cigarettes in terms of oxidative stress and indices of endothelial activation in human pulmonary microvascular endothelial cells (HPMVEC). Ten smoking-naïve healthy subjects (mean age ± SD = 28.7± 5.5 years) were subjected to an e-cig challenge following which their serum was monitored for markers of inflammation [C-reactive protein (CRP) and soluble intercellular adhesion molecule (sI...
Source: Am J Physiol Lung Ce... - May 1, 2019 Category: Respiratory Medicine Authors: Chatterjee S, Tao JQ, Johncola A, Guo W, Caporale A, Langham MC, Wehrli FW Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Flow cytometric analysis of the leukocyte landscape during bleomycin-induced lung injury and fibrosis in the rat.
In conclusion, after a very early granulocytic recruitment, inflammation in rat lungs is observed by activated macrophages and high release of IL-6, and fibrotic remodeling is characterized by recovery of the macrophage population together with TIMP, IL-10 and IL-18 production. Recruited monocytes and a second peak of neutrophils appear in the transitioning phase, correlating with immunostaining of arginase 1 in the tissue, revealing the importance of events leading the changes from injury to aberrant repair. PMID: 31042078 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - May 1, 2019 Category: Respiratory Medicine Authors: Kloth C, Gruben N, Ochs M, Knudsen L, Lopez-Rodriguez E Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Maternal High Fat Diet Alters Lung Development and Function in the Offspring.
In conclusion, maternal HFD disrupts signaling pathways in the early developing lung and may contribute to deficiencies in lung function and increased susceptibility in adults. PMID: 31042079 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - May 1, 2019 Category: Respiratory Medicine Authors: Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD, Rogers LK Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Caveolin-1 Scaffolding Domain Peptide Prevents Hyperoxia-Induced Airway Remodeling in a Neonatal Mouse Model.
Abstract Reactive airway diseases are significant sources of pulmonary morbidity in neonatal and pediatric patients. Supplemental oxygen exposure in premature infants contributes to airway diseases such as asthma, and promotes development of airway remodeling, characterized by increased airway smooth muscle (ASM) mass and extracellular matrix (ECM) deposition. Decreased plasma membrane caveolin-1 (CAV1) expression has been implicated in airway disease and may contribute to airway remodeling and hyperreactivity. Here, we investigated the impact of clinically relevant moderate hyperoxia (50% O2) on airway remodeling...
Source: Am J Physiol Lung Ce... - May 1, 2019 Category: Respiratory Medicine Authors: Vogel ER, Manlove LJ, Kuipers I, Thompson MA, Fang YH, Freeman MR, Britt RD, Faksh A, Yang B, Prakash YS, Pabelick CM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

(Pro)renin receptor regulates lung development via the Wnt/ β-catenin signaling pathway.
CONCLUSION: (P)RR regulates lung development through canonical Wnt/β-catenin signaling and may present a new target for strategies to treat lung hypoplasia. PMID: 31042081 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - May 1, 2019 Category: Respiratory Medicine Authors: Liu J, Zhou Y, Liu Y, Li L, Chen Y, Liu Y, Song R, Peng H Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Organic dust induces inflammatory gene expression in lung epithelial cells via ROS-dependent STAT-3 activation.
In this study, we have identified STAT-3 as an important transcription factor controlling the induction of expression of immune and inflammatory mediators by poultry dust extracts in airway epithelial cells and in mouse lungs and delineated cellular pathway for STAT-3 activation. Poultry dust extract activated STAT-3 phosphorylation in Beas2B and normal human bronchial epithelial cells and in mouse lungs. Chemical inhibition and siRNA knockdown of STAT-3 suppressed induction of immune and inflammatory mediator levels. Antioxidants suppressed increase of STAT-3 phosphorylation by poultry dust extract indicating that oxidati...
Source: Am J Physiol Lung Ce... - May 1, 2019 Category: Respiratory Medicine Authors: Natarajan K, Meganathan V, Mitchell CT, Boggaram V Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Role of Fibroblast Growth Factor 23 and Klotho Crosstalk in Idiopathic Pulmonary Fibrosis.
In this study, Kl levels were assessed in human plasma and primary lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF-FB) and in lung tissue from mice exposed to bleomycin, which showed significant downregulation when compared to controls. Conversely, transgenic mice overexpressing KL were protected against bleomycin-induced lung fibrosis. Treatment of human lung fibroblasts with recombinant KL alone was not sufficient to inhibit TGF-b-induced collagen deposition and inflammatory marker expression. Interestingly, Fibroblast Growth Factor (FGF)23, a pro-inflammatory circulating protein for which KL is a ...
Source: Am J Physiol Lung Ce... - May 1, 2019 Category: Respiratory Medicine Authors: Barnes JW, Duncan D, Helton S, Hutcheson S, Kurundkar D, Logsdon NJ, Locy ML, Garth J, Denson R, Farver C, Vo HT, King G, Kentrup D, Faul C, Kulkarni T, De Andrade JA, Yu Z, Matalon S, Thannickal VJ, Krick S Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

LncRNA MALAT1, a lncRNA acting via the miR-204/ZEB1 pathway, mediates the EMT induced by organic extract of PM2.5 in lung bronchial epithelial cells.
Abstract Extensive cohort studies have explored the hazards of PM2.5 to human respiratory health; however, the molecular mechanisms for PM2.5 carcinogenesis are poorly understood. Long non-coding RNAs (lncRNAs) are involved in various pathophysiological processes. In the present study, we investigated the effect of PM2.5 on the epithelial-mesenchymal transition (EMT) in lung bronchial epithelial cells and the underlying mechanisms mediated by an lncRNA. Organic extracts of PM2.5 from Shanghai were used to treat human bronchial epithelial cell lines (HBE and BEAS-2B). The PM2.5 organic extracts induced the EMT and ...
Source: Am J Physiol Lung Ce... - May 1, 2019 Category: Respiratory Medicine Authors: Luo F, Wei H, Guo H, Li Y, Feng Y, Bian Q, Wang Y Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Sex-specific Differences in Emphysema Using a Murine Antisense Oligonucleotide Model of Alpha-1 Antitrypsin Deficiency.
Abstract Alpha-1 antitrypsin (AAT) deficiency is the leading genetic cause of emphysema; however, until recently, no genuine animal models of AAT deficiency existed hampering the development of new therapies. This shortcoming is now addressed by both AAT-null and antisense oligonucleotide mouse models. The goal of this study was to more fully characterize the antisense oligonucleotide model. Both liver AAT mRNA and serum AAT levels were lower in anti-AAT vs. control oligonucleotide treated mice after 6, 12, and 24-weeks. Six and twelve weeks of anti-AAT oligonucleotide therapy induced emphysema that was worse in f...
Source: Am J Physiol Lung Ce... - April 24, 2019 Category: Respiratory Medicine Authors: Joshi R, Ojha M, Lewis J, Fan Q, Monia B, Guo S, Varisco BM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Dynamic airway constriction in rats: heterogeneity and response to deep inspiration.
Abstract Airway narrowing due to hyper-responsiveness severely limits gas exchange in patients with asthma. Imaging studies in humans and animals have previously shown that bronchoconstriction causes patchy patterns of ventilation defects throughout the lungs, and several computational models have predicted that these regions are due to constriction of smaller airways. However, these imaging approaches are often limited in their ability to capture dynamic changes in small airways, and the patterns of constriction are heterogeneous. To directly investigate regional variations in airway narrowing and the response to...
Source: Am J Physiol Lung Ce... - April 24, 2019 Category: Respiratory Medicine Authors: Phung TN, Sinclair SE, Makena PS, Molthen RC, Waters CM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Cathepsin S Promotes the Development of Pulmonary Arterial Hypertension.
Conclusion: The activity of Cat S in pulmonary vascular remodeling and degradation of elastin fibers through the disruption of PPARγ are pathophysiologically significant in PAH. PMID: 31017016 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 24, 2019 Category: Respiratory Medicine Authors: Chang CJ, Hsu HC, Ho WJ, Chang GJ, Pang JS, Chen WJ, Huang CC, Lai YJ Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research