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Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions
J Toxicol Sci. 2021;46(6):283-288. doi: 10.2131/jts.46.283.ABSTRACTAbasic sites are formed in cells by various factors including environmental mutagens and considered to be involved in cancer initiation, promotion, and progression. A chemically stable abasic site analog (tetrahydrofuran-type analog, THF) induces untargeted base substitutions as well as targeted substitution and large deletion mutations in human cells. The untargeted substitutions may be initiated by the cleavage of the DNA strand bearing THF by the human apurinic/apyrimidinic endonuclease 1 (APE1) protein, the major repair enzyme for THF and abasic sites. ...
Source: Journal of Toxicological Sciences - June 3, 2021 Category: Toxicology Authors: Tetsuya Suzuki Yuri Katayama Yasuo Komatsu Hiroyuki Kamiya Source Type: research
