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Total 964 results found since Jan 2013.
Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways
CONCLUSION: Our study demonstrated that spermidine rescues intestinal barrier defects in mice with colitis via the AhR-Nrf2 and AhR-STAT3 pathways, providing a potential therapeutic agent for IBD and other conditions associated with dysregulated gut barrier function.PMID:37104918 | DOI:10.1016/j.intimp.2023.110166
Source: International Immunopharmacology - April 27, 2023 Category: Allergy & Immunology Authors: Bing Yan Xinjie Mao Shasha Hu Shimin Wang Xiaochen Liu Jing Sun Source Type: research
p38 MAPK activation and STIM1-Orai3 association mediate TRPC6 externalization
Am J Physiol Cell Physiol. 2023 Apr 24. doi: 10.1152/ajpcell.00425.2022. Online ahead of print.ABSTRACTEndothelial cell (EC) migration is critical for the repair of monolayer disruption following angioplasties, but migration is inhibited by lipid oxidation products, including lysophosphatidylcholine (lysoPC), which open canonical transient receptor potential 6 (TRPC6) channels. TRPC6 activation requires an increase in intracellular Ca2+ concentration ([Ca2+]i), the source of which is unknown. LysoPC can activate phospholipase A2 to release arachidonic acid (ArA). ArA can activate arachidonic acid-regulated calcium (ARC) ch...
Source: American Journal of Physiology. Cell Physiology - April 24, 2023 Category: Cytology Authors: Pinaki Chaudhuri Priya Putta Michael A Rosenbaum Linda M Graham Source Type: research
1166 Kinome siRNA screening for the treatment of the XPC cancer-prone disease
Xeroderma Pigmentosium C is a rare autosomal recessive genodermatosis. Patients with this disorder carry a mutation in DNA damage recognition protein XPC belonging to the nucleotide excision repair (NER) pathway. This generates a phenotype characterized by extreme photosensitivity and accumulation of UV-induced DNA damage without a repair potential. XP-C and normal patient-derived cells were used to screen a library of siRNAs aimed at decreasing the expression of all human kinases, given their involvement in different DNA repair pathways.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: F. Kobaisi, E. Sulpice, A. Nasrallah, X. Gidrol, W. Rachidi Source Type: research
The effect of silencing the Tip60 gene on the response to radiotherapy in breast cancer cells
In this study, for the first time, the role of the silenced and active Tip60 gene in response to radiotherapy in MDA-MB-231 and MCF-7 cells was investigated. For this purpose, the Tip60 gene was silenced by applying siRNA to the cell lines and UV was applied. In the study, cytotoxicity and DNA breaks were measured by MTT and COMET methods, and mRNA and protein expression values were measured by PCR and Raman spectrophotometer in silenced, unsilenced, UV-treated, and non-UV-treated cell lines. According to the results of the study, increased DNA damage was observed in MCF-7 cell lines in which the Tip60 gene was silenced, a...
Source: Breast - April 17, 2023 Category: Cancer & Oncology Authors: Ece Miser-Saliho ğlu Bensu Karahalil Meri ç Arda Eşmakaya U ğur Tamer Sevgi Yardim-Akaydin Source Type: research
