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Procedure: Gastroschisis Repair

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Total 964 results found since Jan 2013.

Contribution of NADPH oxidase to the retention of UVR-induced DNA damage by arsenic
Toxicol Appl Pharmacol. 2021 Nov 16;434:115799. doi: 10.1016/j.taap.2021.115799. Online ahead of print.ABSTRACTArsenic is a naturally occurring element present in food, soil and water and human exposure is associated with increased cancer risk. Arsenic inhibits DNA repair at low, non-cytotoxic concentrations and amplifies the mutagenic and carcinogenic impact of other DNA-damaging agents, such as ultraviolet radiation (UVR). Arsenic exposure leads to oxidation of zinc coordinating cysteine residues, zinc loss and decreased activity of the DNA repair protein poly(ADP)ribose polymerase (PARP)-1. Because arsenic stimulates NA...
Source: Toxicology and Applied Pharmacology - November 19, 2021 Category: Toxicology Authors: Karen L Cooper Lindsay B Volk Dayna R Dominguez Antonia D Duran K J Ke Jian Liu Laurie G Hudson Source Type: research

CDK4/6 Inhibition and Radiation as a Treatment Strategy to Improve Local Disease Control in Breast Cancers With Poor Prognoses
CONCLUSION: RB loss mitigates CDK4/6 inhibitor-mediated radiosensitization of both ER+ and TNBC cells. Loss of RB expression prevents CDK4/6i-mediated radiosensitization, suggesting that RB expression may be a valuable clinical biomarker to predict efficacy of CDK4/6i + RT in future clinical trials. Our data also provide the preclinical rationale for CDK4/6i with RT not just in ER+ BC, but also in women with TNBC that express RB.PMID:34700581 | DOI:10.1016/j.ijrobp.2021.07.143
Source: Ann Oncol - October 27, 2021 Category: Cancer & Oncology Authors: A Pesch N Hirsh A R Michmerhuizen B Chandler K Wilder-Romans L Lerner M Liu D F Hayes E Cobain L J Pierce J Rae C Speers Source Type: research

Osteogenically differentiated mesenchymal stem cells promote the apoptosis of human umbilical vein endothelial cells in vitro
This article is protected by copyright. All rights reserved
Source: Biotechnology and Applied Biochemistry - October 25, 2021 Category: Biochemistry Authors: Miaomiao Chai, Mingli Jiang, Ce Gu, Qiaohui Lu, Yi Zhou, Ziyang Jin, Yan Zhou, Wensong Tan Tags: Original Article Source Type: research

Noncanonical Wnt5a signaling regulates tendon stem/progenitor cells senescence
CONCLUSION: Our results demonstrate a critical role of noncanonical Wnt5a signaling in TSPCs senescence, and Wnt5a could be an attractive therapeutic target for antagonizing tendon aging.PMID:34663475 | DOI:10.1186/s13287-021-02605-1
Source: Cell Research - October 19, 2021 Category: Cytology Authors: Minhao Chen Yingjuan Li Longfei Xiao Guangchun Dai Panpan Lu Yunfeng Rui Source Type: research

Morphological changes of macrophages and their potential contribution to tendon healing
Colloids Surf B Biointerfaces. 2021 Oct 1;209(Pt 1):112145. doi: 10.1016/j.colsurfb.2021.112145. Online ahead of print.ABSTRACTPoor healing ability and adhesion formation greatly hinder the recovery of injured tendon function. Previously, our local sustained gene delivery system by using cyclooxygenases (COX-1 and COX-2)-engineered miRNA plasmid/nanoparticles loaded hydrogel significantly inhibited adhesion formation and promoted tendon healing. The present study aims to study morphological changes of the macrophages in the healing tendons after above treatment with the hydrogel. Firstly, we assessed the therapeutic effect...
Source: Colloids and Surfaces - October 12, 2021 Category: Biotechnology Authors: Qian Qian Yang Luzhong Zhang You Lang Zhou Jin Bo Tang Source Type: research

Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart
Conclusions: Our data demonstrates that exosome-associated MFGE8 on one hand enhances opsonization of dead cells and on the other activates phagocytic signaling thus augmenting removal of apoptotic cells, resolution of inflammation and therefore efficient cardiac recovery after injury.PMID:34623174 | DOI:10.1161/CIRCRESAHA.120.317900
Source: Circulation Research - October 8, 2021 Category: Cardiology Authors: Mallikarjun Patil Sherin Saheera Praveen K Dubey Asher Kahn-Krell Prem Kumar Govindappa Sarojini Singh Sultan Tousif Qinkun Zhang Hind Lal Jianyi Zhang Gangjian Qin Prasanna Krishnamurthy Source Type: research