Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart

Conclusions: Our data demonstrates that exosome-associated MFGE8 on one hand enhances opsonization of dead cells and on the other activates phagocytic signaling thus augmenting removal of apoptotic cells, resolution of inflammation and therefore efficient cardiac recovery after injury.PMID:34623174 | DOI:10.1161/CIRCRESAHA.120.317900

Source: Circulation Research - October 8, 2021 Category: Cardiology Authors: Mallikarjun Patil Sherin Saheera Praveen K Dubey Asher Kahn-Krell Prem Kumar Govindappa Sarojini Singh Sultan Tousif Qinkun Zhang Hind Lal Jianyi Zhang Gangjian Qin Prasanna Krishnamurthy Source Type: research