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Total 964 results found since Jan 2013.
PTPRU, a quiescence-induced receptor tyrosine phosphatase negatively regulates osteogenic differentiation of human mesenchymal stem cells
Biochem Biophys Res Commun. 2022 Oct 20;636(Pt 1):41-49. doi: 10.1016/j.bbrc.2022.10.062. Online ahead of print.ABSTRACTBone marrow mesenchymal stem cells (MSCs) are heterogeneous osteo-progenitors that are mainly responsible for bone regeneration and homeostasis. In vivo, a subpopulation of bone marrow MSCs persists in a quiescent state, providing a source of new cells for repair. Previously, we reported that induction of quiescence in hMSCs in vitro skews their differentiation potential in favour of osteogenesis while suppressing adipogenesis. Herein, we uncover a new role for a protein tyrosine phosphatase, receptor typ...
Source: Cell Research - November 4, 2022 Category: Cytology Authors: Mohammad Rumman Jyotsna Dhawan Source Type: research
GSE203325 DNA polymerase epsilon interacts with SUVH2/9 to mediate meiotic DSB associated gene silencing beyond DNA methylation in Arabidopsis miRNA-seq
Contributors : Cong Wang ; Chenjiang You ; Yingxiang WangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Arabidopsis thalianaMeiotic recombination is initiated from the SPORULATION 11 (SPO11)-triggered formation of double strand breaks (DSBs) that usually occur in open chromatin with active transcriptional features in many eukaryotes. However, gene transcription at meiotic DSB sites appears to be detrimental for repair, and the mechanisms for gene silencing at DSB sites are largely undefined, especially in plants. Here, we demonstrate that the largest DNA polymerase epsilon subunit POL2A inte...
Source: GEO: Gene Expression Omnibus - October 9, 2022 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE203263 DNA polymerase epsilon interacts with SUVH2/9 to mediate meiotic DSB associated gene silencing beyond DNA methylation in Arabidopsis BiSulfite-seq
Contributors : Cong Wang ; Chenjiang You ; Yingxiang WangSeries Type : Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaMeiotic recombination is initiated from the SPORULATION 11 (SPO11)-triggered formation of double strand breaks (DSBs) that usually occur in open chromatin with active transcriptional features in many eukaryotes. However, gene transcription at meiotic DSB sites appears to be detrimental for repair, and the mechanisms for gene silencing at DSB sites are largely undefined, especially in plants. Here, we demonstrate that the largest DNA polymerase epsilon subunit POL2A interac...
Source: GEO: Gene Expression Omnibus - October 9, 2022 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus
Nucleic Acids Res. 2022 Oct 6:gkac853. doi: 10.1093/nar/gkac853. Online ahead of print.ABSTRACTMultifunctional protein APE1/APEX1/HAP1/Ref-1 (designated as APE1) plays important roles in nuclease-mediated DNA repair and redox regulation in transcription. However, it is unclear how APE1 regulates the DNA damage response (DDR) pathways. Here we show that siRNA-mediated APE1-knockdown or APE1 inhibitor treatment attenuates the ATR-Chk1 DDR under stress conditions in multiple immortalized cell lines. Congruently, APE1 overexpression (APE1-OE) activates the ATR DDR under unperturbed conditions, which is independent of APE1 nucl...
Source: Cell Research - October 6, 2022 Category: Cytology Authors: Jia Li Haichao Zhao Anne McMahon Shan Yan Source Type: research
miR-3059-3p Regulates Glioblastoma Multiforme Radiosensitivity Enhancement through the Homologous Recombination Pathway of DNA Repair
CONCLUSION: Downregulation of DNA2 via miR-3059-3p enhanced the radiosensitivity of GBM cells through the inhibition of the HR pathway.PMID:36185623 | PMC:PMC9519319 | DOI:10.1155/2022/7250278
Source: Journal of Oncology - October 3, 2022 Category: Cancer & Oncology Authors: Yu-Wen Cheng Chien-Ju Lin Shih-Hsun Kuo Ann-Shung Lieu Chee-Yin Chai Hung-Pei Tsai Aij-Lie Kwan Source Type: research
DNA-PKcs participated in hypoxic pulmonary hypertension
CONCLUSIONS: Our study indicated the potential mechanism of DNA-PKcs in the development of HPH. It might provide insights into new therapeutic targets for pulmonary vascular remodeling and pulmonary hypertension.PMID:36114572 | DOI:10.1186/s12931-022-02171-x
Source: Cell Research - September 16, 2022 Category: Cytology Authors: Ying-Ying Liu Wei-Yun Zhang Meng-Lan Zhang Yu-Ji Wang Xi-Yan Ma Jung-Hong Jiang Ran Wang Da-Xiong Zeng Source Type: research
IKK α aggravates renal fibrogenesis by positively regulating the Wnt/β-catenin pathway
Immunology. 2022 Aug 15. doi: 10.1111/imm.13567. Online ahead of print.ABSTRACTAKI (acute kidney injury) with maladaptive repair plays exacerbated role in renal fibrosis characterized by tubulointerstitial fibrosis. Previously, we reported that IKKα contributed to kidney regeneration and inhibited inflammation. Here, we first identified the role and mechanism of IKKα on TGF-β1-induced fibrosis in human tubular epithelial cells and fibrotic kidneys. IKKα was up-regulated in kidney tubular epithelium in unilateral ureteral obstruction (UUO) and unilateral ischemic reperfusion injury (UIRI) mice. Immunohistochemical stain...
Source: Immunology - September 2, 2022 Category: Allergy & Immunology Authors: Hao Zhang Binbin Pan Wenjuan Huang Mengqing Ma Feng Zhang Linglin Jiang Cheng Qian Xin Wan Changchun Cao Source Type: research
Chondroitin sulfate modified chitosan nanoparticles as an efficient and targeted gene delivery vehicle to chondrocytes
In conclusion, CH-CS nanoparticles can be considered as a candidate for gene therapy purposes in cartilage diseases.PMID:36049252 | DOI:10.1016/j.colsurfb.2022.112786
Source: Colloids and Surfaces - September 1, 2022 Category: Biotechnology Authors: Naghmeh Akbari Moghadam Fatemeh Bagheri Mohamadreza Baghaban Eslaminejad Source Type: research
