Effectiveness of a Global Multidisciplinary Supportive and Educational Intervention in Thermal Resort on Anthropometric and Biological Parameters, and the Disease-Free Survival after Breast Cancer Treatment Completion (PACThe).
Authors: Vasson MP, Kwiatkowski F, Rossary A, Jouvency S, Mouret-Reynier MA, Duclos M, Van Praagh-Doreau I, Travade A, Bignon YJ Abstract A growing knowledge highlights the strong benefit of regular physical activity in the management of breast cancer patients, but few studies have considered biological parameters in their outcomes. In the prospective randomised trial after breast cancer treatment completion "PACThe," we determined the effects of physical activity and nutritional intervention on the biological and anthropometric status of patients after one year of follow-up, and clarified the link betwee...
Source: Journal of Oncology - May 28, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Erratum to "Frizzled-10 Extracellular Vesicles Plasma Concentration Is Associated with Tumoral Progression in Patients with Colorectal and Gastric Cancer".
Erratum to "Frizzled-10 Extracellular Vesicles Plasma Concentration Is Associated with Tumoral Progression in Patients with Colorectal and Gastric Cancer". J Oncol. 2020;2020:6153432 Authors: Scavo MP, Cigliano A, Depalo N, Fanizza E, Bianco MG, Denora N, Laquintana V, Curri ML, Lorusso D, Lotesoriere C, Panarese A, Giannelli G Abstract [This corrects the article DOI: 10.1155/2019/2715968.]. PMID: 32454824 [PubMed - in process] (Source: Journal of Oncology)
Source: Journal of Oncology - May 28, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

The Comparison of Laparoscopic Colorectal Resection with Natural Orifice Specimen Extraction versus Mini-Laparotomy Specimen Extraction for Colorectal Tumours: A Systematic Review and Meta-Analysis of Short-Term Outcomes.
Conclusions: NOSES was shown to be a safe and viable alternative to CLAPS in colorectal oncology in terms of short-term results. Further long-term and randomized trials are required. PMID: 32454825 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 28, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Communication Needs of Cancer Patients and/or Caregivers: A Critical Literature Review.
Conclusions: Cancer patients and/or caregivers have different communication needs in terms of target, content, style, and communication timing. A better understanding of the unique communication needs of patients and/or caregivers will offer health professionals detailed information on designing appropriate interventions to support cancer patients and caregivers. PMID: 32454826 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 28, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Overcoming Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutated Tumours.
Authors: Paton EL, Turner JA, Schlaepfer IR Abstract Overactivation of the mitogen-activated protein kinase (MAPK) pathway is an important driver of many human cancers. First line, FDA-approved therapies targeting MAPK signalling, which include BRAF and MEK inhibitors, have variable success across cancers, and a significant number of patients quickly develop resistance. In recent years, a number of preclinical studies have reported alternative methods of overcoming resistance, which include promoting apoptosis, modulating autophagy, and targeting mitochondrial metabolism. This review summarizes mechanisms of resist...
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

GASC1-Adapted Neoadjuvant Chemotherapy for Resectable Esophageal Squamous Cell Carcinoma: A Prospective Clinical Biomarker Trial.
Authors: Jia R, Mi Y, Yuan X, Kong D, Li W, Li R, Wang B, Zhu Y, Kong J, Ma Z, Li N, Mi Q, Gao S Abstract Neoadjuvant chemotherapy (NCT) is a standard care for esophageal squamous cell carcinoma (ESCC), but the efficacy is unsatisfactory. Cancer stem cells (CSCs) play key roles in chemotherapy resistance. Gene amplified in squamous cell carcinoma 1 (GASC1) is a neoteric gene in stemness maintaining of ESCC. We aimed to reveal whether GASC1 could be a predictive biomarker for NCT in ESCC. ESCC patients (T2-4N0-2M0) were evaluated for GASC1 expression using immunohistochemical staining and classified as GASC1-low gro...
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Comparison of Laparoscopy and Laparotomy in Early-Stage Endometrial Cancer: Early Experiences from a Developing Country.
Authors: Cakmak Y, Comert DK, Sozen I, Oge T Abstract After minimally invasive surgery gained popularity in gynecology, laparoscopic operations became widespread among oncologic operations. However, more studies evaluating experiences of oncologic surgeons during the learning period of laparoscopy are needed. To compare the surgical outcomes and perioperative complications of laparoscopic surgery and laparotomy in the treatment of early-stage endometrioid endometrial cancer patients, we retrospectively investigated patients who underwent surgery due to endometrial cancer at our institution between 2014 and 2018. Ea...
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

CD40 is Positively Correlated with the Expression of Nucleophosmin in Cisplatin-Resistant Bladder Cancer.
Authors: Luo C, Lei T, Zhao M, Meng Q, Zhang M Abstract Objective: To verify and evaluate the value of CD40 as a noninvasive biomarker of cisplatin-resistant bladder cancer, we studied the expression of CD40 and the correlation between nucleophosmin (NPM1) and CD40 in cisplatin-resistant bladder cancer. Methods: Three cisplatin-resistant bladder cancer cell lines (T24/0.8DDP, BIU87/0.3DDP, and PUMC-91/0.6DDP) were studied, and lentivirus was used to silence NPM1 expression. The expression of CD40 and NPM1 in three NPM1 silencing bladder cancer cell lines were detected by fluorescence microscopy and Western Blot...
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Extracellular Vesicles Involvement in the Modulation of the Glioblastoma Environment.
Authors: Ciccocioppo F, Lanuti P, Marchisio M, Miscia S Abstract Glioblastoma (GBM) is the most deadly primary brain tumour and is a paradigmatic example of heterogeneous cancer. Although expanding data propose the phenotypic plasticity exhibited by glioblastoma cells, as a critical feature involved in the tumour development and posttherapy recurrence, the central machinery responsible for their aggressiveness remains elusive. Despite decades of research, the complex biology of the glioblastoma is still unknown. Progress in genetic and epigenetic discoveries has improved diagnostic classification, prognostic inform...
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Detection of Fusion Genes Using a Targeted RNA Sequencing Panel in Gastrointestinal and Rare Cancers.
Authors: Lee SJ, Hong JY, Kim K, Kim KM, Kang SY, Lee T, Kim ST, Park SH, Park YS, Lim HY, Kang WK, Lee J, Park JO Abstract Successful identification and targeting of oncogenic gene fusion is a major breakthrough in cancer treatment. Here, we investigate the therapeutic implications and feasibility of using a targeted RNA sequencing panel to identify fusion genes in gastrointestinal and rare cancers. From February through December 2017, patients with gastrointestinal, hepatobiliary, gynecologic, sarcoma, or rare cancers were recruited for a clinical sequencing project at Samsung Medical Center (NCT #02593578). The ...
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Targeted Molecular Therapy in Glioblastoma.
Authors: Festuccia C, Biordi AL, Tombolini V, Hara A, Bailey D PMID: 32411237 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Cell Survival Is Regulated via SOX9/BCL2L1 Axis in HCT-116 Colorectal Cancer Cell Line.
Authors: Lizárraga-Verdugo E, Ruiz-García E, López-Camarillo C, Bermúdez M, Avendaño-Félix M, Ramos-Payán R, Romero-Quintana G, Ayala-Ham A, Villegas-Mercado C, Pérez-Plasencia C, Aguilar-Medina M Abstract Colorectal cancer (CRC) is one of the most frequent types of malignancies and one of the major causes of cancer-related death worldwide. Sex-determining region Y (SRY)-box 9 protein (SOX9) is a member of the SOX family of transcription factors which are involved in the regulation of differentiation and development. Recently, several reports suggest an import...
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Negative Predictive Value of Human Papillomavirus Testing: Implications for Anal Cancer Screening in People Living with HIV/AIDS.
Conclusions: In this series, anal hrHPV DNA testing offered 92% NPV for PLWHA; in other words, a 8% risk of occult precancer remains for those who test hrHPV negative on anal swab samples. PMID: 32411239 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Efficacy of Panobinostat for the Treatment of Multiple Myeloma.
Authors: Eleutherakis-Papaiakovou E, Kanellias N, Kastritis E, Gavriatopoulou M, Terpos E, Dimopoulos MA Abstract Panobinostat represents a potent oral nonselective pan-histone deacetylase inhibitor (HDAC) with activity in myeloma patients. It has been approved by the FDA and EMA in combination with bortezomib and dexamethasone for the treatment of multiple myeloma, in patients who have received at least two prior regimens, including bortezomib and an immunomodulatory agent. In order to further explore its clinical potential, it is evaluated in different combinations in relapsed/refractory and newly diagnosed multi...
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

AdipoRon Affects Cell Cycle Progression and Inhibits Proliferation in Human Osteosarcoma Cells.
In conclusion, our findings provide initial evidence of AdipoR as an anticancer molecule differently affecting various signaling pathways involved in cell cycle and cell death in osteosarcoma cells and encourage the design of future studies to further understand its pattern of activities. PMID: 32411241 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Thirty-Day Outcomes after Surgery for Primary Sarcomas of the Extremities: An Analysis of the NSQIP Database.
Conclusion: Approximately 1 in 7 patients will experience a complication in the first thirty days following surgery for primary bone and soft tissue sarcomas of the extremities. The unique risk profiles of lower extremity and amputation cases should be considered during perioperative planning and surveillance. PMID: 32411242 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Identification of a Gene-Related Risk Signature in Melanoma Patients Using Bioinformatic Profiling.
Conclusions: The gene pattern differences in melanoma were profiled, and a gene signature that could independently predict melanoma patients with a high risk of poor survival was established, highlighting the relationship between prognosis and the local immune response. PMID: 32411243 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Seroprevalence of Human Betaretrovirus Surface Protein Antibodies in Patients with Breast Cancer and Liver Disease.
Authors: Zhang G, Bashiri K, Kneteman M, Cave K, Hong Y, Mackey JR, Alter HJ, Mason AL Abstract Mouse mammary tumor virus (MMTV) is a betaretrovirus that plays a causal role in the development of breast cancer and lymphoma in mice. Closely related sequences that share 91-99% nucleotide identity with MMTV have been repeatedly found in humans with neoplastic and inflammatory diseases. Evidence for infection with a betaretrovirus has been found in patients with breast cancer and primary biliary cholangitis and referred to as the human mammary tumor virus and the human betaretrovirus (HBRV), respectively. Using the gol...
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Predictive Value of FOLFOX-Based Regimen, Long Interval, Hemoglobin Levels and Clinical Negative Nodal Status, and Postchemoradiotherapy CEA Levels for Pathological Complete Response in Patients with Locally Advanced Rectal Cancer after Neoadjuvant Chemoradiotherapy.
Authors: Huang CM, Huang CW, Ma CJ, Yeh YS, Su WC, Chang TK, Tsai HL, Juo SH, Huang MY, Wang JY Abstract We aimed to identify predictors of a pathological complete response (pCR) in patients with locally advanced rectal cancer (LARC) following a multimodality therapy. We retrospectively reviewed 236 patients with LARC treated with neoadjuvant chemoradiotherapy (CRT) followed by radical resection from January 2011 to December 2017. Patients were administered CRT, which comprised radiotherapy and chemotherapy with an oxaliplatin plus 5-fluorouracil- or fluoropyrimidine-based regimen. Clinical factors were correlated ...
Source: Journal of Oncology - May 17, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Gelsolin Promotes Cancer Progression by Regulating Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma and Correlates with a Poor Prognosis.
Authors: Zhang Y, Luo X, Lin J, Fu S, Feng P, Su H, He X, Liang X, Liu K, Deng W Abstract Gelsolin (GSN), a cytoskeletal protein, is frequently overexpressed in different cancers and promotes cell motility. The biological function of GSN in hepatocellular carcinoma (HCC) and its mechanism remain unclear. The expression of GSN was assessed in a cohort of 188 HCC patients. The effects of GSN on the migration and invasion of tumour cells were examined. Then, the role of GSN in tumour growth in vivo was determined by using a cancer metastasis assay. The possible mechanism by which GSN promotes HCC progression was explo...
Source: Journal of Oncology - May 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

miR-200b/200a/429 Cluster Stimulates Ovarian Cancer Development by Targeting ING5.
Authors: Guan W, Cui H, Huang P, Chun WJ, Lee JW, Kim H, Zou H Abstract Ovarian cancer is the second most common gynaecological malignancy, and microRNAs (miRNAs) play important role in the cancer development. Here, we found that the level of miR-200b/200a/429 was significantly increased in serum and tumor tissues of patients with stage-I ovarian cancer. Consistent with these results, we detected increased expression levels of miR-200b/200a/429 in ovarian cancer cell lines compared with the human nontumorigenic ovarian epithelial cell line T80. The overexpression of miR-200b/200a/429 in T80 cells stimulated prolife...
Source: Journal of Oncology - May 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

ALDH3B2 Polymorphism Is Associated with Colorectal Cancer Susceptibility.
In this study, we tested the coding variants in the alcohol metabolic genes and the risk of CRC, by using 485 cases and 516 controls. A total of 16 germline coding variants in 10 alcohol metabolic genes were genotyped. We identified that rs3741178 in ALDH3B2 was significantly associated with CRC risk with odds ratio being 2.13 (95% CI: 1.24-3.68, P=0.0064). Further functional annotation suggested that this variant may damage the protein function of ALDH3B2. Our results suggested that ALDH3B2 in the alcohol metabolism pathway contributed to the development of CRC, which may contribute to the prevention of this disease in th...
Source: Journal of Oncology - May 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Recent Findings in the Posttranslational Modifications of PD-L1.
Authors: Li SM, Zhou J, Wang Y, Nie RC, Chen JW, Xie D Abstract Immune checkpoint therapy, such as the reactivation of T-cell activity by targeting programmed cell death 1 (PD-1) and its ligand PD-L1 (also called B7-H1 and CD274) has been found pivotal in changing the historically dim prognoses of malignant tumors by causing durable objective responses. However, the response rate of immune checkpoint therapy required huge improvements. It has been shown that the expression of PD-L1 on cancer cells and immune cell membranes is correlated with a more durable objective response rate to PD-L1 antibodies, which highligh...
Source: Journal of Oncology - May 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Mucinous Histology, BRCA1/2 Mutations, and Elevated Tumor Mutational Burden in Colorectal Cancer.
Authors: Harpaz N, Gatt YE, Granit RZ, Fruchtman H, Hubert A, Grinshpun A Abstract Mucinous colorectal carcinomas (MC) constitute 10% of colorectal malignancies. Recently, an increased risk of colorectal cancer has been demonstrated in germline BRCA1/2 mutation carriers. Furthermore, BRCA1/2 germline mutation carriers have exhibited a higher-than-expected frequency of MC tumors. Here, we investigate the relationship between BRCA mutations and mucinous histology in colorectal carcinoma patients, using both an existing cohort of sequenced colorectal tumors and a prospective case-control study comparing MC and convent...
Source: Journal of Oncology - May 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Role of Molecular Chaperones in Carcinogenesis: Mechanism, Diagnosis, and Treatment.
Authors: Conway de Macario E, Pitruzzella A, D'Amico AG PMID: 32377195 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Circulating Tumor DNA Using Tagged Targeted Deep Sequencing to Assess Minimal Residual Disease in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.
Authors: Cirmena G, Garuti A, De Mariano M, Coco S, Ferrando L, Isnaldi E, Barbero V, Fregatti P, Del Mastro L, Ferrando F, Gonella R, Garlaschi A, Friedman D, Ballestrero A, Zoppoli G Abstract In breast cancer patients undergoing neoadjuvant chemotherapy before surgery, there is an unmet need for noninvasive predictive biomarkers of response. The analysis of circulating tumor DNA (ctDNA) in particular has been the object of several reports, but few of them have studied the applicability of tagged targeted deep sequencing (tTDS) to clinical practice and its performance compared with droplet digital PCR (ddPCR). Her...
Source: Journal of Oncology - May 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Prognostic Significance of the Tumor-Stromal Ratio in Invasive Breast Cancer and a Proposal of a New Ts-TNM Staging System.
This study aimed at exploring the prognostic significance of the TSR in invasive breast cancer using immunohistochemistry (IHC)-stained tissue microarrays (TMAs) and integrating the TSR into the traditional tumor-node-metastasis (TNM) staging system. Methods: The prepared 7 TMAs containing 240 patients with 480 invasive BC specimens were stained with cytokeratin (CK) by the IHC staining method. The ratio of tumor cells and stromal cells was visually assessed. TSR > 1 and TSR ≤ 1 were categorized as the high TSR (low stroma) and low TSR (high stroma) groups, respectively, and the progno...
Source: Journal of Oncology - May 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Expression of Tumour-Associated MUC1 Is a Poor Prognostic Marker in Breast Cancer in Kumasi, Ghana.
This study aims at addressing the expression profiles of MUC1 and other biomarkers in Ghanaian breast cancer and determines its predictive and prognostic characteristics, in relation to other clinicopathological features. Methods: Haematoxylin and eosin (H&E) slides of breast cancer cases were reviewed and 203 suitable cases were selected for tissue microarray (TMA) construction and immunohistochemistry. Anti-ER, PR, HER2, Ki-67, and MUC1 antibodies were used. Results from the immunostaining were analysed using SPSS version 23. Results: About 59% of cases expressed MUC1. Majority of cases in the study showed a ...
Source: Journal of Oncology - May 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Effect of Lymphadenectomy on Survival in Early-Stage Type II Endometrial Carcinoma and Carcinosarcoma.
Conclusions: Systematic pelvic and paraaortic lymph node dissection independently and significantly prolongs the survival of patients with early-stage type II endometrial carcinoma and carcinosarcoma. PMID: 32351564 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 2, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Is Tumor-Free Distance an Independent Prognostic Factor for Early-Stage Endometrioid Endometrial Cancer?
In conclusion, tumor-free distance is not an independent prognostic factor for patients with stage IB endometrioid endometrial cancer. PMID: 32351565 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 2, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Impact of Genetic Variation in TLR4 3'UTR on NSCLC Genetic Susceptibility.
This study aimed to investigate the association of the SNPs in TLR genes with the susceptibility to NSCLC. This case-control study involved 700 lung cancer patients and 700 healthy controls. All individuals were genotyped for all selected SNPs in TLR genes using polymerase chain reaction (PCR) test-based restriction fragment length polymorphism (PCR-RFLP) and TaqMan SNP genotyping assay. The association of genetic variations in TLRs with the susceptibility to NSCLC was evaluated by unconditional logistic regression with OR (95% CI). After evaluating transcriptional factor or miRNA binding capability by bioinformatics metho...
Source: Journal of Oncology - May 2, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Nomogram for Predicting Long-Term Survival after Synchronous Resection for Hepatocellular Carcinoma and Inferior Vena Cava Tumor Thrombosis: A Multicenter Retrospective Study.
Conclusions: Curative-intent surgery should be carefully evaluated and suggested according to our novel IVCTT classification. We have developed a visual web-based nomogram model to predict oncological prognosis of curative-intent surgery for HCC patients with IVCTT. PMID: 32322268 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - April 25, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Diverting Ileostomy Duration Is the Main Determinant of Ileostomy-Related Complications after Surgical Treatment of Rectum Cancer.
This study aimed to investigate factors associated with the development of ileostomy complications in rectal cancer patients, including those who received neoadjuvant treatment. Methods: This retrospective trial included 133 consecutive patients who underwent surgery for rectal cancer with temporary diverting ileostomy. Patients' demographic characteristics as well as the pre- and postclosure outcomes and complications were analyzed. Results: In logistic regression analysis, longer duration of ileostomy emerged as a significant independent predictor of any complication during ileostomy. The respective odds ratios f...
Source: Journal of Oncology - April 25, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Update on Pathophysiology, Treatment, and Complications of Carcinoid Syndrome.
Authors: Clement D, Ramage J, Srirajaskanthan R Abstract Carcinoid syndrome (CS) develops in patients with hormone-producing neuroendocrine neoplasms (NENs) when hormones reach a significant level in the systemic circulation. The classical symptoms of carcinoid syndrome are flushing, diarrhoea, abdominal pain, and wheezing. Neuroendocrine neoplasms can produce multiple hormones: 5-hydroxytryptamine (serotonin) is the most well-known one, but histamine, catecholamines, and brady/tachykinins are also released. Serotonin overproduction can lead to symptoms and also stimulates fibrosis formation which can result in dev...
Source: Journal of Oncology - April 25, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Effects of BRCA Germline Mutations on Triple-Negative Breast Cancer Prognosis.
Authors: Pogoda K, Niwińska A, Sarnowska E, Nowakowska D, Jagiełło-Gruszfeld A, Siedlecki J, Nowecki Z Abstract Germline BRCA1 and BRCA2 mutations confer an increased lifetime risk for breast cancer and ovarian cancer. Several studies have investigated prognosis among BRCA1/2 mutation carriers and noncarriers, but the prognostic impact on outcomes of breast cancer patients has not been determined. The aim of this study was to determine the prognosis of TNBC patients with and without BRCA1/2 germline mutation. Among 502 patients diagnosed with TNBC between 2005 and 2008, 124 patients with a strong family history ...
Source: Journal of Oncology - April 25, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?
Authors: Fucarino A, Pitruzzella A Abstract Cancers are one of the major challenges faced by modern medicine both because of their impact in terms of the amount of cases and of the ineffectiveness of therapies used today. A concrete support to the fight against them can be found in the analysis and understanding of the molecular mechanisms involving molecular chaperones. In particular, HSP60 and HSP10 seem to play an important role in carcinogenesis, supporting tumours in their proliferation, survival, and metastasis. Efforts must be directed toward finding ways to eliminate or block this "mistaken" chape...
Source: Journal of Oncology - April 24, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Significance of SUV Max for Predicting Occult Lymph Node Metastasis and Prognosis in Early-Stage Tongue Squamous Cell Carcinoma.
Conclusion: An SUV max>9.7 was a marker for occult lymph node metastasis and could decrease LRC in patients with cT1-2N0 tongue SCC. PMID: 32318108 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - April 24, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Corrigendum to "Circulating Cancer Stem Cell-Derived Extracellular Vesicles as a Novel Biomarker for Clinical Outcome Evaluation".
Corrigendum to "Circulating Cancer Stem Cell-Derived Extracellular Vesicles as a Novel Biomarker for Clinical Outcome Evaluation". J Oncol. 2020;2020:8947367 Authors: Brocco D, Lanuti P, Simeone P, Bologna G, Pieragostino D, Cufaro MC, Graziano V, Peri M, Di Marino P, De Tursi M, Grassadonia A, Rapposelli IG, Pierdomenico L, Ercolino E, Ciccocioppo F, Del Boccio P, Marchisio M, Natoli C, Miscia S, Tinari N Abstract [This corrects the article DOI: 10.1155/2019/5879616.]. PMID: 32318109 [PubMed - in process] (Source: Journal of Oncology)
Source: Journal of Oncology - April 24, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Comparison between Intensity-Modulated Radiotherapy and Three-Dimensional Conformal Radiotherapy for Their Effectiveness in Esophageal Cancer Treatment: A Retrospective Single Institution Study.
Authors: Bai XH, Dang J, Chen ZQ, He Z, Li G Abstract Although a large number of influential studies that have been conducted worldwide on locally advanced esophageal cancer (EC) have employed the treatment modality of three-dimensional conformal radiotherapy (3D-CRT), an advanced as well as highly conformal technology known as intensity-modulated radiotherapy (IMRT) has attracted increasing attention from the radiotherapy research community. This is because of the clear advantages of IMRT, including decrease in radiation dose that reaches critical cardiopulmonary organs. These two treatment modalities need to be i...
Source: Journal of Oncology - April 22, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

New Insights into the Screening, Prompt Diagnosis, Management, and Prognosis of Breast Cancer.
Authors: Domeyer PJ, Sergentanis TN PMID: 32308682 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - April 22, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

The DNMT1/miR-34a/FOXM1 Axis Contributes to Stemness of Liver Cancer Cells.
Conclusions: We revealed that aberrant activation of DNMT1 causes miR-34a promoter methylation and suppression, leading to FoxM1 upregulation by disinhibition and promotion of LCSC stemness. These findings suggest that blockage of DNMT1/miR-34a-mediated FOXM1 upregulation might suppress liver cancer by targeting LCSCs. PMID: 32308683 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - April 22, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Using Media to Promote Public Awareness of Early Detection of Kaposi's Sarcoma in Africa.
Authors: Laker-Oketta M, Butler L, Kadama-Makanga P, Inglis R, Wenger M, Katongole-Mbidde E, Maurer T, Kambugu A, Martin J Abstract Background: Despite its hallmark cutaneous presentation, most Kaposi's sarcoma (KS) in Africa is diagnosed too late for effective treatment. Early diagnosis will only be achievable if patients with KS present earlier for care. We hypothesized that public awareness about KS can be enhanced through exposure to common media. Methods: We developed educational messages regarding early detection of KS for the general African public portraying a three-part theme: "Look" (regular...
Source: Journal of Oncology - April 15, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

The Clinical Relevance of p16 and p53 Status in Patients with Squamous Cell Carcinoma of the Vulva.
Authors: Barlow EL, Lambie N, Donoghoe MW, Naing Z, Hacker NF Abstract Objective: To investigate the prognostic significance of HPV status in vulvar squamous cell carcinomas (VSCC) and to determine whether preoperative determination of p16 or p53 status would have clinical relevance. Methods: Patients treated for VSCC at a tertiary hospital in Sydney, Australia, from 2002 to 2014, were retrospectively evaluated (n = 119). Histological specimens were stained for p53 and p16 expression, and HPV status was determined by PCR detection of HPV DNA. Results: HPV DNA was detected in 19%, p16 expressio...
Source: Journal of Oncology - April 15, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Diagnostic, Prognostic, and Predictive Biomarkers in Breast Cancer.
Authors: Li CJ, Chen HM, Lai JC PMID: 32256579 [PubMed - as supplied by publisher] (Source: Journal of Oncology)
Source: Journal of Oncology - April 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

EGFR Polymorphism and Survival of NSCLC Patients Treated with TKIs: A Systematic Review and Meta-Analysis.
Authors: Jurisic V, Vukovic V, Obradovic J, Gulyaeva LF, Kushlinskii NE, Djordjević N Abstract Tyrosine kinase inhibitor- (TKI-) based therapy revolutionized the overall survival and the quality of life in non-small-cell lung cancer (NSCLC) patients that have epidermal growth factor receptor (EGFR) mutations. However, EGFR is a highly polymorphic and mutation-prone gene, with over 1200 single nucleotide polymorphisms (SNPs). Since the role of EFGR polymorphism on the treatment outcome is still a matter of debate, this research analyzed the available literature data, according to the PRISMA guidelines for meta-anal...
Source: Journal of Oncology - April 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Are Basal-Like and Non-Basal-Like Triple-Negative Breast Cancers Really Different?
Conclusion: Both BL and NBL subtypes occur in equal proportions; hence, basalness and triple negativity are not synonyms. Though BL and NBL are prognostically similar, BL subtype shows a trend towards slightly shorter DFS and OS compared to NBL. PMID: 32256581 [PubMed - as supplied by publisher] (Source: Journal of Oncology)
Source: Journal of Oncology - April 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Infection-Associated Cancers.
Authors: Yoshiyama H, Ueda K, Komano J, Iizasa H PMID: 32256582 [PubMed - as supplied by publisher] (Source: Journal of Oncology)
Source: Journal of Oncology - April 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Dual HER2 Blockade versus a Single Agent in Trastuzumab-Containing Regimens for HER2-Positive Early Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Conclusions: Despite being associated with more toxicity, trastuzumab-containing dual anti-HER2 therapy is superior to trastuzumab single agent for HER2-positive EBC independent of hormone receptor status. The correlation between survival and LN status needs further verification. Trastuzumab plus pertuzumab or plus neratinib is the preferred regimen with substantial efficacy and lower toxicity. PMID: 32256583 [PubMed - as supplied by publisher] (Source: Journal of Oncology)
Source: Journal of Oncology - April 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Pathological Mechanistic Studies of Osimertinib Resistance in Non-Small-Cell Lung Cancer Cells Using an Integrative Metabolomics-Proteomics Analysis.
Conclusion: The regulation of HIF-1 and PI3K-Akt signaling pathway, energy supply process, and amino acids metabolism are the promising therapeutic tactics for osimertinib resistance. PMID: 32256584 [PubMed - as supplied by publisher] (Source: Journal of Oncology)
Source: Journal of Oncology - April 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Somatic Mutations in HER2 and Implications for Current Treatment Paradigms in HER2-Positive Breast Cancer.
Authors: Gaibar M, Beltrán L, Romero-Lorca A, Fernández-Santander A, Novillo A Abstract In one of every four or five cases of breast cancer, the human epidermal growth factor receptor-2 (HER2) gene is overexpressed. These carcinomas are known as HER2-positive. HER2 overexpression is linked to an aggressive phenotype and a lower rate of disease-free and overall survival. Drugs such as trastuzumab, pertuzumab, lapatinib, neratinib, and the more recent afatinib target the deregulation of HER2 expression. Some authors have attributed somatic mutations in HER2, a role in resistance to anti-HER2 therapy as ...
Source: Journal of Oncology - April 8, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research