Assessment of Quality of Life of Free Anterolateral Thigh Flap for Reconstruction of Tissue Defects of Total or Near-Total Glossectomy.
Conclusion: Free anterolateral thigh perforator flaps for reconstruction of total or near-total glossectomy defects after cancer resection would have significantly influenced the patients' oral functions and quality of life. PMID: 33101411 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 28, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Distant Metastases in Patients with Intrahepatic Cholangiocarcinoma: Does Location Matter? A Retrospective Analysis of 370 Patients.
Authors: Hahn F, Müller L, Mähringer-Kunz A, Tanyildizi Y, Dos Santos DP, Düber C, Galle PR, Weinmann A, Kloeckner R Abstract Background: Intrahepatic cholangiocarcinoma (ICC) is an aggressive tumor entity, and distant metastases are common. However, studies investigating patterns and clinical relevance of distant metastases are rare. Therefore, we aimed to analyze occurrence, location, and prognostic impact of distant metastases on overall survival (OS). Methods: Between 1997 and 2018, 417 patients with ICC were treated at our tertiary care center. Distant metastases and intrahepatic tumor burde...
Source: Journal of Oncology - October 28, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Low Advanced Lung Cancer Inflammation Index Predicts Poor Prognosis in Locally Advanced Nasopharyngeal Carcinoma Patients Treated with Definitive Concurrent Chemoradiotherapy.
Authors: Topkan E, Ozdemir Y, Kucuk A, Guler OC, Sezer A, Besen AA, Mertsoylu H, Senyurek S, Kilic Durankus N, Bolukbasi Y, Selek U, Pehlivan B Abstract Purpose: We aimed to retrospectively investigate the prognostic worth of pretreatment advanced lung cancer inflammation index (ALI) in locally advanced nasopharyngeal carcinoma (LA-NPC) patients treated with concurrent chemoradiotherapy (C-CRT). Patients and Methods. A total of 164 LA-NPC patients treated with cisplatinum-based definitive C-CRT were included in this retrospective cohort analysis. The convenience of ideal pre-C-CRT ALI cut-offs affecting survival re...
Source: Journal of Oncology - October 22, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Cancer Stem Cell Characteristics by Network Analysis of Transcriptome Data Stemness Indices in Breast Carcinoma.
Conclusion: This study is the first to show the important role of stemness-related genes in the prognosis of BC. However, future clinical trials are needed to confirm these results and promote the application of these key genes in prognosis evaluation. PMID: 33082784 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 22, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Efficacy and Safety of First-Line Immunotherapy in Combination with Chemotherapy for Patients with Extensive-Stage Small Cell Lung Cancer: A Systematic Review and Network Meta-Analysis.
Conclusion: In the first-line setting, combining immunotherapy with chemotherapy is better than standard chemotherapy in terms of OS and PFS. Across the eligible studies, PD-L1 inhibitors might be preferred. Further explorations of more ICIs in the first-line treatment for extensive-stage SCLC patients should be needed. PMID: 33061969 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 21, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Safety and Efficacy of Long-Term Zoledronic Acid in Advanced Breast Cancer with Bone Metastasis in South China.
Authors: Wang Q, Guo G, Ruan Z, Cao H, Guo Y, Bai L, Jiang C, Liu S, He W, Huang J, Rong Y, Chen X, Xia L, Zhang B, Peng R Abstract Background: This retrospective study aimed to characterize the long-term (>24 months) safety profile of zoledronic acid (ZA). We aimed to investigate whether long-term ZA treatment had greater benefits than short-term treatment in patients from southern China with advanced breast cancer (ABC) with bone metastasis. Patients and Methods. A total of 566 metastatic breast cancer cases were included and divided into two groups according to the duration of ZA treatment. The included patie...
Source: Journal of Oncology - October 21, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Nomograms Predict Overall Survival and Cancer-Speci fic Survival in Patients with Fibrosarcoma: A SEER-Based Study.
Conclusion: We developed the nomograms that estimated 3-year and 5-year OS and CSS. These nomograms not only have good discrimination performance and calibration but also provide patients with better clinical benefits. PMID: 33061971 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 21, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Bioinformatics-Based Identification of a circRNA-miRNA-mRNA Axis in Esophageal Squamous Cell Carcinomas.
Conclusion: This study provides support for the possible mechanisms of disease progression in ESCC. PMID: 33061972 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 21, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Circ_0072088 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Cancer by Absorbing miR-377.
In conclusion, circ_0072088 might be used as a diagnostic biomarker and therapeutic target for ESCC. PMID: 33061973 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 21, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Adequacy of Cancer-Related Pain Treatments and Factors Affecting Proper Management in Ayder Comprehensive Specialized Hospital, Mekelle, Ethiopia.
Conclusion: This study suggests that cancer pain management in ACSH was sufficient for only 56%. However, large numbers of individuals are suffering from a manageable pain. Hence, remedial action should be taken, including increasing awareness of symptom management in medical staff and incorporating existing knowledge into routine clinical practice. PMID: 33029141 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 9, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Performance of Distress Thermometer and Associated Factors of Psychological Distress among Chinese Cancer Patients.
Conclusion: DT with a cutoff score (≥4) is a comprehensive, appropriate, and practical initial screener for PD in cancer patients. Predicting factors should be considered together for effective management of PD in such population. PMID: 33029142 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 9, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

A Novel Prognostic Index Based on the Analysis of Glycolysis-Related Genes in Head and Neck Squamous Cell Carcinomas.
Conclusion: Our findings provide new insights into the role of glycolysis in HNSCC. The identified genes predict the patient prognosis and might substantially contribute to the development of individualized treatments. PMID: 33029143 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 9, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Prognostic Factors in Patients with Rhabdomyosarcoma Using Competing-Risks Analysis: A Study of Cases in the SEER Database.
Conclusions: A prognostic nomogram model based on the competing-risks model has been established for predicting the probability of death in patients with RMS. This validated prognostic model may be useful when choosing treatment strategies and for predicting survival. PMID: 33014049 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

CEP131 Abrogates CHK1 Inhibitor-Induced Replication Defects and Is Associated with Unfavorable Outcome in Neuroblastoma.
In this study, we discovered that PF-477736 increased expression of MDM2 oncogene along with CHK1i-induced replication defects in neuroblastoma NB-39-nu cells. A mass spectrometry analysis of protein binding to MDM2 in the presence of CHK1i identified the centrosome-associated family protein 131 (CEP131), which was correlated with unfavorable prognosis of neuroblastoma patients. We revealed that MDM2 was associated with CEP131 protein degradation, whereas overexpression of CEP131 accelerated neuroblastoma cell growth and exhibited resistance to CHK1i-induced replication defects. Thus, these findings may provide a future th...
Source: Journal of Oncology - October 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Observational Study of Clinical Practice in Patients with Pancreatic Adenocarcinoma in Greece.
Conclusion: This study described the significant improvement in prognosis of PAC patients receiving palliative chemotherapy and the relatively high rate of receipt of second-line chemotherapy, according to real-world data. However, due to the nonrandomized nature of the study, any comparison between different chemotherapy regimens should be regarded with caution. PMID: 33014051 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Somatic Mutation Profiling of Intrahepatic Cholangiocarcinoma: Comparison between Primary and Metastasis Tumor Tissues.
Conclusions: In this study, the identification of two meaningful mutated genes, BRAF and LRP1B, highly mutated immune gene harbored by primary ICC patients. Both in PSs and MSs, no patients with MSI-H showed PDL1 positive. The Notch pathway had more alteration genes in patients with MSI-H. And the enrichment of the platinum drug resistance pathway in MSs might offer reference for the novel therapeutic strategy of ICC. PMID: 33014052 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Clinical Features and Long-Term Survival of Metastatic Hepatic Neuroendocrine Neoplasms Secondary to Gastroenteropancreatic Site: An Analysis by Applying the Grading Classification.
Authors: Yang M, Zeng L, Hou SZ, Ke NW, Tian BL, Liu XB, Xiang B, Zhang Y Abstract Method: Data of patients who were surgically treated and clinicopathologically diagnosed as (MH)-NENs secondary to (GEP)-NENs at West China Hospital of Sichuan University from January 2006 to December 2018 were retrospectively collected and analyzed by the grading classification for (GEP)-NENs. Results: We identified 150 patients with (MH)-NENs secondary to (GEP)-NENs, including 10 patients with G1 NETs, 26 with G2 NETs, 33 with G3 NETs, and 81 with G3 NECs. There were significant differences between patients with G1/G2/G3 NETs a...
Source: Journal of Oncology - October 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Clinical Significance of the Interleukin 24 mRNA Level in Head and Neck Squamous Cell Carcinoma and Its Subgroups: An In Silico Investigation.
In this study, the clinical implication of IL24 mRNA was evaluated in the common subgroups of HNSCC, including oral squamous cell carcinoma (OSCC), nasopharyngeal carcinoma (NPC), and laryngeal squamous cell carcinoma (LSCC) for analysis. Substantial IL24 mRNA expression data were calculated from several databases, such as the Gene Expression Omnibus (GEO), ArrayExpress, Sequence Read Archive (SRA), ONCOMINE, and The Cancer Genome Atlas (TCGA) databases. We ultimately collected a total of 41 microarrays and RNA-seq including 1,564 HNSCC and 603 noncancer tissue samples. IL24 mRNA was highly expressed in OSCC, LSCC, and NPC...
Source: Journal of Oncology - October 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

A Novel Signature Based on mTORC1 Pathway in Hepatocellular Carcinoma.
Conclusion: The mTORC1-associated gene signature established and validated in our research could be used as a potential prognostic factor in HCC. PMID: 33014055 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Integrin Beta 1 Promotes Glioma Cell Proliferation by Negatively Regulating the Notch Pathway.
In this study, genes associated with the Notch signaling pathway in gliomas were analyzed using bioinformatics and in vitro experiments. The dataset GSE22772 was downloaded from the Gene-Cloud of Biotechnology Information database. Differentially expressed genes (DEGs) between short hairpin RNA (shRNA) intervening glioma cells and control cells were screened using the unpaired t test. Functional enrichment analysis was performed, and coexpression network was analyzed to identify the most important genes associated with the Notch signaling pathway. Integrin beta 1 (ITGB1) mRNA and protein levels in clinical glioma tumor sam...
Source: Journal of Oncology - October 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic.
Authors: Afshari AR, Mollazadeh H, Sahebkar A Abstract One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features. Its invasiveness is responsible for the high recurrence even after maximal surgical interventions. Minocycline is a semisynthetic analog of tetracyclines with potential anti-inflammatory and anticancer effects, distinct from its antimicrobial activity. In this review, we highlight the importance and the cytotoxic mechanisms of minocycline on GBM pathophysiology. Considering the role of certain e...
Source: Journal of Oncology - October 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Equipping the American Joint Committee on Cancer Staging for Resectable Pancreatic Ductal Adenocarcinoma with Tumor Grade: A Novel Staging System.
This study aimed to construct a novel staging system with greater prognostication for resectable PDAC by incorporating tumor grade into the 8th AJCC system. Methods: A total of 9966 patients with resectable PDAC from the Surveillance Epidemiology and End Results (SEER) database were randomly separated into training and interval validation sets. Another 324 patients from our center were included as an external validation set. We proposed a novel staging system by sorting the substages yielded by a combination of T, N, and tumor grade based on their overall survival (OS) and grouping them into several stages. Prognostic ...
Source: Journal of Oncology - October 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Efficiency of High and Standard b Value Diffusion-Weighted Magnetic Resonance Imaging in Grading of Gliomas.
Conclusion: The ADC values decrease with an increase in tumor cellularity. Meanwhile, high b value provides better tissue contrast by reflecting more tissue diffusivity. Therefore, ADC-derived parameters at high b value are more useful in the grading of glioma than those obtained at standard b value. They might be a better surrogate imaging sequence in the preoperative evaluation of gliomas. PMID: 33005190 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - October 3, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Tyrosine Kinase Inhibitors as a Treatment of Symptomatic CNS Metastases in Oncogene-Driven NSCLC.
In conclusion, upfront use of next-generation TKIs in patients with oncogene-driven NSCLC with symptomatic CNS metastases is associated with reasonable intracranial activity and represents a valuable treatment option. PMID: 32963526 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - September 25, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Transcriptional Expressions of CXCL9/10/12/13 as Prognosis Factors in Breast Cancer.
Authors: Li Y, Liang M, Lin Y, Lv J, Chen M, Zhou P, Fu F, Wang C Abstract CXCLs play critical roles in antitumor immunity by activating tumor-specific immune responses and stimulating tumor proliferation, thus affecting patient outcomes. However, the expression and prognostic values of CXCLs in breast cancer have not been well clarified. The aim of this study was to investigate the impact of CXCLs transcriptional expression on breast cancer patients. Oncomine database, GEPIA (Gene Expression Profiling Interactive Analysis), UALCAN, Kaplan-Meier Plotter, TIMER (Tumor Immune Estimation Resource), and DAVID were used...
Source: Journal of Oncology - September 25, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

BRCA Mutations in Prostate Cancer: Prognostic and Predictive Implications.
Authors: Messina C, Cattrini C, Soldato D, Vallome G, Caffo O, Castro E, Olmos D, Boccardo F, Zanardi E Abstract Despite chemotherapy and novel androgen-receptor signalling inhibitors (ARSi) have been approved during the last decades, metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease with poor clinical outcomes. Several studies found that germline or acquired DNA damage repair (DDR) defects affect a high percentage of mCRPC patients. Among DDR defects, BRCA mutations show relevant clinical implications. BRCA mutations are associated with adverse clinical features in primary tumors and...
Source: Journal of Oncology - September 25, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Bioinformatic Identification of Neuroblastoma Microenvironment-Associated Biomarkers with Prognostic Value.
Authors: Wang Y, Luo H, Cao J, Ma C Abstract The microenvironment plays a vital role in the tumor recurrence of neuroblastoma. This research aimed at exploring prognostic genes that are involved in neuroblastoma microenvironment. We used "estimate" R package to calculate the immune/stromal/ESTIMATE scores of each sample of ArrayExpress dataset E-MTAB-8248 based on the ESTIMATE algorithm. Then we found that immune/stromal/ESTIMATE scores were not correlated with age/chromosome 11q, but tumor stage, MYCN gene amplifications, and chromosome 1p. Samples were then divided into high- and low-score groups, and 2...
Source: Journal of Oncology - September 25, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Corrigendum to "Mucinous Histology, BRCA1/2 Mutations, and Elevated Tumor Mutational Burden in Colorectal Cancer".
Corrigendum to "Mucinous Histology, BRCA1/2 Mutations, and Elevated Tumor Mutational Burden in Colorectal Cancer". J Oncol. 2020;2020:6725209 Authors: Harpaz N, Gatt YE, Granit RZ, Fruchtman H, Hubert A, Grinshpun A Abstract [This corrects the article DOI: 10.1155/2020/6421205.]. PMID: 32963530 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - September 25, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Observational Study Comparing Efficacy and Safety between Neoadjuvant Concurrent Chemoradiotherapy and Chemotherapy for Patients with Unresectable Locally Advanced or Metastatic Gastric Cancer.
Conclusion: Neoadjuvant CCRT achieved more favorable OS and PFS than did neoadjuvant chemotherapy alone, without significant increases of toxicity in patients. However, prospective randomized trials comparing treatment modalities are necessary to confirm the potential advantages of neoadjuvant CCRT. PMID: 32963531 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - September 25, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Genes Involved in the PD-L1 Pathway Might Associate with Radiosensitivity of Patients with Gastric Cancer.
This study aims to explore the relationship between the expression levels of genes involved in the PD-L1 pathway and radiosensitivity for gastric cancer patients. A total of 367 patients with clinical survival information and radiotherapy information were obtained in The Cancer Genome Atlas (TCGA). Genes involved in the PD-L1 pathway were categorized into high and low expression level groups according to the median value. The Cox proportional hazards model was used to find the association between gene expression level and radiosensitivity. The results show that high expression levels of CD274, EGFR, RAF1, RPS6KB1, PIK3CA, ...
Source: Journal of Oncology - September 25, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Corrigendum to "HDAC and HMT Inhibitors in Combination with Conventional Therapy: A Novel Treatment Option for Acute Promyelocytic Leukemia".
Corrigendum to "HDAC and HMT Inhibitors in Combination with Conventional Therapy: A Novel Treatment Option for Acute Promyelocytic Leukemia". J Oncol. 2020;2020:1834190 Authors: Vitkevičienė A, Skiauterytė G, Žučenka A, Stoškus M, Gineikienė E, Borutinskaitė V, Griškevičius L, Navakauskienė R Abstract [This corrects the article DOI: 10.1155/2019/6179573.]. PMID: 32952555 [PubMed - in process] (Source: Journal of Oncology)
Source: Journal of Oncology - September 23, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Next-Generation Sequencing Characterizes the Landscape of Somatic Mutations and Pathways in Metastatic Bile Tract Carcinoma.
Conclusions: We identified multiple pathway differences, which helps us better understand metastatic biliary tumors and design clinical therapy for personalized medicine. PMID: 32952556 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - September 23, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Comparison of Involved Field Radiotherapy versus Elective Nodal Irradiation in Stage IIIB/C Non-Small-Cell Lung Carcinoma Patients Treated with Concurrent Chemoradiotherapy: A Propensity Score Matching Study.
Authors: Topkan E, Ozdemir Y, Guler OC, Kucuk A, Besen AA, Mertsoylu H, Sezen D, Akdemir EY, Sezer A, Bolukbasi Y, Pehlivan B, Selek U Abstract Background: We retrospectively compared the incidence of isolated elective nodal failure (IENF) and toxicity rates and survival outcomes after elective nodal irradiation (ENI) versus involved-field RT (IFRT) by employing the propensity score matching (PSM) methodology in stage IIIB/C inoperable non-small-cell lung cancer (NSCLC) patients treated with definitive concurrent chemoradiotherapy (C-CRT). Methods: Our PSM examination included 1048 stage IIIB/C NSCLC patients t...
Source: Journal of Oncology - September 23, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Diagnostic Accuracy of Procalcitonin, Neutrophil-to-Lymphocyte Ratio, and C-Reactive Protein in Detection of Bacterial Infections and Prediction of Outcome in Nonneutropenic Febrile Patients with Lung Malignancy.
This study was designed to evaluate their value in differentiating infectious fever from tumor fever (TF) and to investigate their role in assessing outcomes in nonneutropenic lung cancer patients (NNLCPs). Methods: This retrospective clinical study included 588 febrile NNLCPs between January 2019 and December 2019. The levels of PCT, CRP, and conventional inflammatory markers, including white blood cells (WBC) and neutrophils (NEU), were measured. NLR was defined as the ratio of the absolute neutrophil count to the absolute lymphocyte count. Patients' clinical and bacteriological data were recorded. Results: This ...
Source: Journal of Oncology - September 12, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Expression and Correlation of Cell-Free cIAP-1 and cIAP-2 mRNA in Breast Cancer Patients: A Study from India.
Authors: Verma AK, Ahmad I, Yadav P, Rahmani AH, Khan B, Alsahli MA, Joshi PC, Ahmad H, Ali Beg MM Abstract Background: Inhibitors of apoptosis proteins such as cIAP-1 and cIAP-2 have recently emerged as the key mechanism in resistance to apoptosis in various cancers and lead to cell survival. Therefore, the present study aimed to evaluate the cIAP-1 and cIAP-2 expression in breast cancer patients, as well as their association with overall patient survival. Methods: Histopathologically confirmed 100 invasive ductal carcinoma patients and healthy controls were included in the present study. Total RNA extraction ...
Source: Journal of Oncology - September 12, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Concordance of Genomic Alterations between Circulating Tumor DNA and Matched Tumor Tissue in Chinese Patients with Breast Cancer.
In this study, we analyzed the genomic alteration profiles of 81 solid BC samples and 41 liquid BC samples. The concordance across 136 genes was evaluated. Results: The median mutation counts per sample in 41 ctDNA samples was higher than the median in 81 tissue samples (p=0.0254; Wilcoxon rank sum test). For mutation at the protein-coding level, 39.0% (16/41) samples had at least one concordant mutation in two biopsies. 20.0% tissue-derived mutations could be detected via ctDNA-based sequencing, whereas 11.7% ctDNA-derived mutations could be found in paired tissues. At gene amplification level, the overall concordant ...
Source: Journal of Oncology - September 12, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Clinicopathological and Prognostic Value of Gastric Carcinoma Highly Expressed Transcript 1 in Cancer: A Meta-Analysis.
Conclusions: High lncRNA GHET1 expression can predict poor survival and pathological parameters. And lncRNA GHET1 could serve as a new indicator in multiple cancers. PMID: 32908508 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - September 12, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Comparison of Transcatheter Arterial Chemoembolization-Radiofrequency Ablation and Transcatheter Arterial Chemoembolization Alone for Advanced Hepatocellular Carcinoma with Macrovascular Invasion Using Propensity Score Analysis: A Retrospective Cohort Study.
Authors: Liu Y, Li Y, Gao F, Zhang Q, Yang X, Zhu B, Niu S, Huang Y, Hu Y, Li W, Wang X Abstract Background: To compare the efficacies of transcatheter arterial chemoembolization (TACE) with radiofrequency ablation (RFA) (TACE + RFA) and TACE alone in patients with hepatocellular carcinoma (HCC) and macrovascular invasion (MVI). Methods: In total, 664 patients having HCC with MVI were included. Of these patients, 141 were treated with TACE + RFA, 254 with TACE alone, and 269 with supportive therapy (control group). The overall survival (OS) was compared among these groups. Propensity...
Source: Journal of Oncology - September 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Endoscopic Esophageal Submucosal Tunnel Dissection for Cystic Lesions Originating from the Muscularis Propria of the Gastric Cardia.
Conclusion: The CLMPGC were mainly mucocele and epidermoid cyst, in an expansive growth pattern, and these lesions had no distinct borders with the muscularis propria. The muscularis propria formed a complete wall of the lesion. There was no direct blood supply to the lesions from big blood vessels. Endoscopic esophageal submucosal tunnel dissection was a safe, feasible, and effective treatment for CLMPGC. PMID: 32884570 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - September 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Prognostic Values for the mRNA Expression of the ADAMTS Family of Genes in Gastric Cancer.
Authors: Liang L, Zhu JH, Chen G, Qin XG, Chen JQ Abstract The "A Disintegrin and Metalloproteinase with Thrombospondin Motif" (ADAMTS) family of genes is involved in the occurrence and development of different cancers. However, the prognostic value of these genes in gastric cancer (GC) has not been revealed. The present study was thus conducted to determine the prognostic value for the ADAMTS family of genes in GC. First, we evaluated the mRNA expression levels of the ADAMTS family in GC patients using a GEPIA dataset. Thereafter, we determined the prognostic value of these genes by analyzing their mRNA ...
Source: Journal of Oncology - September 6, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Mining Database for the Expression and Clinical Significance of NF- κB Family in Hepatocellular Carcinoma.
Conclusion: RelB and NF-κB2 are potential biomarkers for the diagnosis, prognosis, and immunotherapy of HCC. PMID: 32879628 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - September 5, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer.
Authors: Senchukova MA, Makarova EV, Shurygina EI, Volchenko NN Abstract The determination of factors associated with progression of cervical cancer is important, both for a recurrence risk assessment and for determining optimal treatment tactics. Previously, we showed the prognostic value of different types of tumor microvessels (MVs) in gastric and breast cancer. The object of this research was to study the morphology and clinical significance of different tumor microvessels in early cervical cancer. A total of 65 archived paraffin blocks of patients with I-IIA stages of squamous cervical cancer were investigated...
Source: Journal of Oncology - August 29, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

A Prospective, Randomized, Placebo-Controlled Study of a Combination of Simvastatin and Chemotherapy in Metastatic Breast Cancer.
Authors: Alarfi H, Youssef LA, Salamoon M Abstract Preclinical studies support the anticancer activity of statins; however, the existing clinical evidence is inconsistent and not definitive. Our study aimed at evaluating a postulated cancer chemo-sensitizing effect of statin (simvastatin) in a cohort of metastatic breast cancer (MBC) patients. We designed a prospective, single-centered, randomized, double blinded, placebo-controlled trial that encompassed MBC patients with an ECOG Performance Status Scale ≤2 and scheduled to be treated with a chemotherapy regimen consisting of carboplatin and vinorelbine every 3...
Source: Journal of Oncology - August 29, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Physical Properties of Nanoparticles That Result in Improved Cancer Targeting.
Authors: Zein R, Sharrouf W, Selting K Abstract The therapeutic efficacy of drugs is dependent upon the ability of a drug to reach its target, and drug penetration into tumors is limited by abnormal vasculature and high interstitial pressure. Chemotherapy is the most common systemic treatment for cancer but can cause undesirable adverse effects, including toxicity to the bone marrow and gastrointestinal system. Therefore, nanotechnology-based drug delivery systems have been developed to reduce the adverse effects of traditional chemotherapy by enhancing the penetration and selective drug retention in tumor tissues....
Source: Journal of Oncology - August 13, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Clinical Outcome of Carotid Body Paraganglioma Management: A Review of 10-Year Experience.
Conclusions: Surgery is the treatment of choice for carotid body paragangliomas. Complete R0 resection should be justified especially in case of malignancy. Adjuvant chemotherapy or radiotherapy is an option for patients with primary malignancy or relapse. PMID: 32765605 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - August 13, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Low Expression of DDX60 Gene Might Associate with the Radiosensitivity for Patients with Breast Cancer.
In this study, we used the information of patients with breast cancer in the TCGA database for statistical analysis and found that the breast cancer patients with low expression of DDX60 exhibited radiosensitivity. Comparing the radiotherapy groups with the nonradiotherapy groups, for patients with low expression of DDX60, the adjusted hazard ratio (HR) values for radiotherapy were 0.244 (0.064-0.921) and 0.199 (0.062-0.646) in the training and validation datasets, with the p values 0.040 and 0.007, respectively. However, for patients with high expression of DDX60, the adjusted hazard ratio (HR) values were 3.582 (0.627-20...
Source: Journal of Oncology - August 13, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Cancer Incidence Characteristic Evolution Based on the National Cancer Registry in Taiwan.
Conclusions. ASRs of cancer for males increased from 150.93 per 105 individuals in 1988 to 330.03 per 105 individuals in 2016, and, for females, they increased from 124.18 per 105 individuals in 1988 to 269.5 per 105 individuals in 2016. We found that cancer incidence has begun at younger ages and that the rates of cancer incidence are increasing faster. This study shows that the incidence of cancer in males has decreased slightly in recent years, while the incidence of cancer in females has continued to increase. The continuous promotion of health literacy, lifestyle modification, HBV and HPV vaccination, and cancer early...
Source: Journal of Oncology - August 13, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Computational Identification of Tumor Suppressor Genes Based on Gene Expression Profiles in Normal and Cancerous Gastrointestinal Tissues.
Authors: Sun Q, Uddin MN, Li M, Wang X, Lai M Abstract Cancer prevails in various gastrointestinal (GI) organs, such as esophagus, stomach, and colon. However, the small intestine has an extremely low cancer risk. It is interesting to investigate the molecular cues that could explain the significant difference in cancer incidence rates among different GI tissues. Using several large-scale normal and cancer tissue genomics datasets, we compared the gene expression profiling between small intestine and other GI tissues and between GI cancers and normal tissues. We identified 17 tumor suppressor genes (TSGs) which sho...
Source: Journal of Oncology - August 13, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Compensatory Estrogen Signal Is Capable of DNA Repair in Antiestrogen-Responsive Cancer Cells via Activating Mutations.
Authors: Suba Z Abstract Cancer cells are embarrassed human cells exhibiting the remnants of same mechanisms for DNA stabilization like patients have in their healthy cells. Antiestrogens target the liganded activation of ERs, which is the principal means of genomic regulation in both patients and their tumors. The artificial blockade of liganded ER activation is an emergency situation promoting strong compensatory actions even in cancer cells. When tumor cells are capable of an appropriate upregulation of ER signaling resulting in DNA repair, a tumor response may be detected. In contrast, when ER signaling is comp...
Source: Journal of Oncology - August 13, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

The Value of Preoperative Alpha-L-Fucosidase Levels in Evaluation of Malignancy and Differential Diagnosis of Urothelial Neoplasms.
Conclusions: Preoperative AFU levels cannot serve as a reliable predictor for malignant degree and differential diagnosis, including pure UC, UCSD, and SqCC of urothelial tumors. PMID: 32774371 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - August 13, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research