Gastrointestinal Carcinoma with Plasmacytoid Morphology: Positivity for c-MET, Arylsulfatase, and Markers of Epithelial-Mesenchymal Transition, as Indicators of Aggressivity.
Conclusions: Primary carcinoma with plasmacytoid morphology is a dedifferentiated variant of adenocarcinoma or poorly cohesive carcinomas. Vimentin positive dedifferentiated-poorly cohesive carcinomas should be considered as mesenchymal-type highly malignant carcinomas. This rare histologic variant of gastrointestinal cancer might respond to anti-c-MET tyrosine kinases. PMID: 31205468 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - June 19, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

LncRNA PVT1 Mediates Antiapoptosis and 5-Fluorouracil Resistance via Increasing Bcl2 Expression in Gastric Cancer.
Conclusion: Our results showed that PVT1 can inhibit the apoptosis and enhance the 5-Fu resistance of gastric cancer through the activation of Bcl2. PVT1 has the potential to serve as an indicator to predict 5-Fu treatment resistance. PMID: 31205469 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - June 19, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Immune Checkpoint Inhibition in Classical Hodgkin Lymphoma: From Early Achievements towards New Perspectives.
Authors: De Goycoechea D, Stalder G, Martins F, Duchosal MA Abstract Immune checkpoint inhibition (ICI) became one of the major breakthroughs in cancer treatment over the past decade and entered into therapy within standard oncohematology practice. ICI has demonstrated impressive response rates as salvage therapy in relapsed/refractory (R/R) classical Hodgkin lymphoma (cHL) and is now being tested as an adjunction to chemotherapy in the frontline settings. CHL exquisite sensitivity to PD-1/PD-L1 axis inhibition relies on a particular biological background. By contrast, non-Hodgkin lymphomas (NHL) have demonstrated ...
Source: Journal of Oncology - June 19, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Advances in Tumor-Stroma Interactions: Emerging Role of Cytokine Network in Colorectal and Pancreatic Cancer.
Authors: Bazzichetto C, Conciatori F, Falcone I, Cognetti F, Milella M, Ciuffreda L Abstract Cytokines are a family of soluble factors (Growth Factors (GFs), chemokines, angiogenic factors, and interferons), which regulate a wide range of mechanisms in both physiological and pathological conditions, such as tumor cell growth and progression, angiogenesis, and metastasis. In recent years, the growing interest in developing new cancer targeted therapies has been accompanied by the effort to characterize Tumor Microenvironment (TME) and Tumor-Stroma Interactions (TSI). The connection between tumor and stroma is now we...
Source: Journal of Oncology - June 15, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

MicroRNA Expression Changes in Women with Breast Cancer Stratified by DNA Repair Capacity Levels.
Authors: Encarnación-Medina J, Ortiz C, Vergne R, Padilla L, Matta J Abstract Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide and is the leading cause of death among Hispanic women. Previous studies have shown that women with a low DNA repair capacity (DRC), measured through the nucleotide excision repair (NER) pathway, have an increased BC risk. Moreover, we previously reported an association between DRC levels and the expression of the microRNA (miRNA) let-7b in BC patients. MiRNAs can induce genomic instability by affecting the cell's DNA damage response while influencing the c...
Source: Journal of Oncology - June 15, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Low Long Noncoding RNA Growth Arrest-Specific Transcript 5 Expression in the Exosomes of Lung Cancer Cells Promotes Tumor Angiogenesis.
In this study, lung cancer in mice was induced by urethane; we found that growth arrest specific 5 (GAS5) was lowly expressed in the serum exosomes and lung cancer tissues of mice with lung cancer. And there was a significant positive correlation between GAS5 expression in serum exosomes and lung cancer tissues. Furthermore, GAS5 was lowly expressed in human lung cancer tissues, lung cancer cells, and cells culture supernatant exosomes. The exosomes of lung cancer cells promoted human umbilical vein endothelial cells (HUVECs) proliferation and tube formation and inhibited their apoptosis. GAS5 overexpression in lung cancer...
Source: Journal of Oncology - June 14, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer.
Authors: Nowacka-Zawisza M, Raszkiewicz A, Kwasiborski T, Forma E, Bryś M, Różański W, Krajewska WM Abstract Genetic polymorphisms in DNA repair genes may affect DNA repair efficiency and may contribute to the risk of developing cancer. The aim of our study was to investigate single nucleotide polymorphisms (SNPs) in RAD51 (rs2619679, rs2928140, and rs5030789) and XRCC3 (rs1799796) involved in DNA double-strand break repair and their relationship to prostate cancer. The study group included 99 men diagnosed with prostate cancer and 205 cancer-free controls. SNP genotyping was performed using the PCR-RFLP ...
Source: Journal of Oncology - June 14, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Altered CSF Proteomic Profiling of Paediatric Acute Lymphocytic Leukemia Patients with CNS Infiltration.
Conclusions: The levels of those 10 proteins change during the treatment of CNSL. Some of the proteins are likely to play a vital biological role as biomarkers for the development of ALL. In addition, our results indicated the feasible and reproducible utility of CSF for diagnosis and prognosis of patients with CNSL. PMID: 31186631 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - June 14, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Clinical Outcome of Ampullary Carcinoma: Single Cancer Center Experience.
Conclusions: Despite numerous advances in both cancer care and research, efforts in rare malignancies such as Ampullary cancer remain very challenging with a clear lack of an evidence-based standard of care treatment paradigm. Although adding adjuvant therapies such as chemotherapy or chemoradiotherapy is likely to improve survival in high-risk disease, there is no standardized regimen for the treatment of Ampullary cancer. More research is required to elucidate whether statistically and clinically relevant differences exist that may warrant a change in the current adjuvant treatment strategies. PMID: 31186632 [PubMed]...
Source: Journal of Oncology - June 14, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

ANXA2 Silencing Inhibits Proliferation, Invasion, and Migration in Gastric Cancer Cells.
Authors: Xie R, Liu J, Yu X, Li C, Wang Y, Yang W, Hu J, Liu P, Sui H, Liang P, Huang X, Wang L, Bai Y, Xue Y, Zhu J, Fang T Abstract Annexin A2 (ANXA2) has been well known to associate with the progress of malignant tumor. However, the biological behavior of ANXA2 in gastric cancer (GC) remains unclear. We made a hypothesis in transcriptome level from TCGA datasets. Then, we used immunohistochemical staining to quantify the expression level of ANXA2 protein in GC tissues compared with adjacent tissues. Quantitative real-time PCR and western blot were used for analyzing ANXA2 expression in human GC (SGC-7901, MKN-4...
Source: Journal of Oncology - June 14, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Complications of Intrathecal Chemotherapy in Adults: Single-Institution Experience in 109 Consecutive Patients.
Authors: Byrnes DM, Vargas F, Dermarkarian C, Kahn R, Kwon D, Hurley J, Schatz JH Abstract Acute lymphoblastic leukemia and other aggressive lymphoid malignancies like Burkitt leukemia/lymphoma have high incidence of central nervous system (CNS) involvement. Various solid tumors, most notably breast cancer, can also metastasize into the CNS as a late stage complication causing devastating effects. Intrathecal (IT) chemotherapy consisting of methotrexate, cytarabine, or the two in combination is frequently used for the prophylaxis and treatment of CNS metastasis. Because of the high toxicity of these chemotherapeuti...
Source: Journal of Oncology - June 14, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Prognostic Effect of Long Noncoding RNA NEAT1 Expression Depends on p53 Mutation Status in Cancer.
In this study, we comprehensively analyzed the relationship between NEAT1 expression and p53 mutation status. Interestingly, survival analysis based on NEAT1 expression in several cancer tissues revealed that the p53 wild-type group with high NEAT1 expression had a good prognosis, while poor prognosis or no correlation between NEAT1 expression and survival was observed in the p53-mutated group. These results demonstrate that the tumor-suppressive effect of NEAT1 depends on p53 function and is consistent with our previous report showing that NEAT1 supports the tumor-suppressive function of p53. Specifically, NEAT1 seems to ...
Source: Journal of Oncology - June 14, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Prognosis of Small Cell Lung Cancer with Idiopathic Pulmonary Fibrosis: Assessment according to GAP Stage.
Conclusions: Inferior survival outcome and higher incidence of treatment-related pulmonary toxicities were noted in the advanced GAP stage group. Furthermore, advanced GAP stage was the only predictor of treatment-related acute exacerbation of IPF. Physicians should thus consider GAP stage, which reflects the severity of IPF, during treatment of SCLC-IPF. PMID: 31186636 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - June 14, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Overexpression of Kynurenine 3-Monooxygenase Correlates with Cancer Malignancy and Predicts Poor Prognosis in Canine Mammary Gland Tumors.
Authors: Chiu YH, Lei HJ, Huang KC, Chiang YL, Lin CS Abstract Tumor biomarkers are developed to indicate tumor status, clinical outcome, or prognosis. Since currently there are no effective biomarkers for canine mammary tumor (CMT), this study intended to verify whether kynurenine 3-monooxygenase (KMO), one of the key enzymes involved in tryptophan catabolism, is competent for predicting prognosis in patients with CMT. By investigating a series of 86 CMT clinical cases, we found that both gene and protein expression of KMO discriminated malignant from benign CMTs and was significantly higher in stage IV and V tumo...
Source: Journal of Oncology - June 14, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

The Role of Nonerythroid Spectrin αII in Cancer.
The Role of Nonerythroid Spectrin αII in Cancer. J Oncol. 2019;2019:7079604 Authors: Ackermann A, Brieger A Abstract Nonerythroid spectrin αII (SPTAN1) is an important cytoskeletal protein that ensures vital cellular properties including polarity and cell stabilization. In addition, it is involved in cell adhesion, cell-cell contact, and apoptosis. The detection of altered expression of SPTAN1 in tumors indicates that SPTAN1 might be involved in the development and progression of cancer. SPTAN1 has been described in cancer and therapy response and proposed as a potential marker protein for ...
Source: Journal of Oncology - June 14, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Treatment of Spinal Metastases with Epidural Cord Compression through Corpectomy and Reconstruction via the Traditional Open Approach versus the Mini-Open Approach: A Multicenter Retrospective Study.
In conclusion, surgery improved pain, function, and quality of life in patients with MESCC. The mini-open approach resulted in less estimated blood loos, less blood transfusion, and shorter hospitalization than the traditional open approach, while both methods had similar mortality and morbidity rates. Thus, the mini-open approach may be more beneficial than the traditional approach for MESCC. PMID: 31186639 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - June 14, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Identification of Transcriptional Signatures of Colon Tumor Stroma by a Meta-Analysis.
Conclusions: The identification of CTS-specific transcriptional signatures may provide insights into the tumor microenvironment that mediates the development of colon cancer and has potential clinical implications for colon cancer diagnosis and treatment. PMID: 31186640 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - June 14, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

The Combination of Stereotactic Body Radiation Therapy and Immunotherapy in Primary Liver Tumors.
Authors: Kreidieh M, Zeidan YH, Shamseddine A Abstract Treatment recommendations for primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are complex and require a multidisciplinary approach. Despite surgical options that are potentially curative, options for nonsurgical candidates include systemic therapy, radiotherapy (RT), transarterial chemoembolization (TACE), and radiofrequency ablation (RFA). Stereotactic Body Radiation Therapy (SBRT) is now in routine use for the treatment of lung cancer, and there is growing evidence supporting its use in liver tumors. SBRT has...
Source: Journal of Oncology - June 12, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Long-Term Survival, Quality of Life, and Psychosocial Outcomes in Advanced Melanoma Patients Treated with Immune Checkpoint Inhibitors.
Authors: Rogiers A, Boekhout A, Schwarze JK, Awada G, Blank CU, Neyns B Abstract Immune checkpoint inhibitors have become a standard of care option for the treatment of patients with advanced melanoma. Since the approval of the first immune checkpoint (CTLA-4) inhibitor ipilimumab in 2011 and programmed death-1 (PD-1) blocking monoclonal antibodies pembrolizumab and nivolumab thereafter, an increasing proportion of patients with unresectable advanced melanoma achieved long-term overall survival. Little is known about the psychosocial wellbeing, neurocognitive function, and quality of life (QOL) of these survivors. ...
Source: Journal of Oncology - June 12, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Evaluation of Androgen Receptor in Relation to Estrogen Receptor (AR/ER) and Progesterone Receptor (AR/PgR): A New Must in Breast Cancer?
Authors: Bronte G, Rocca A, Ravaioli S, Scarpi E, Bonafè M, Puccetti M, Maltoni R, Andreis D, Martinelli G, Bravaccini S Abstract Steroid nuclear receptors are known to be involved in the regulation of epithelial-mesenchymal transition process with important roles in invasion and metastasis initiation. Androgen receptor (AR) has been extensively studied, but its role in relation to breast cancer patient prognosis remains to be clarified. AR/ER ratio has been reported to be an unfavorable prognostic marker in early primary breast cancer, but its role in the patients with advanced disease has to be cleared. We...
Source: Journal of Oncology - May 23, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Sequential Interventional Management of Osseous Neoplasms via Embolization, Cryoablation, and Osteoplasty.
Authors: Sundararajan SH, Calamita S, Girgis P, Ngo G, Ranganathan S, Giglio M, Gendel V, Goyal S, Nosher J, Roychowdhury S Abstract The purpose of this study is to determine if sequential interventional therapy can become a mainstay option in providing palliation from fastidious osseous neoplasms in patients with pain refractory to oral analgesia and radiotherapy. This retrospective monocentric study was approved by our institutional review board. Between July 2012 and August 2014, we reviewed 15 patients (6 women, 9 men; age range of 36-81 years) who underwent embolization followed by cryoablation, with or withou...
Source: Journal of Oncology - May 23, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Advances in the Management of HPV-Related Oropharyngeal Cancer.
Authors: De Felice F, Tombolini V, Valentini V, de Vincentiis M, Mezi S, Brugnoletti O, Polimeni A Abstract Patients with human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than HPV-negative OPSCC when treated with standard high-dose cisplatin-based chemoradiotherapy. Consistent with this assertion and due to younger age at diagnosis, novel approaches to minimize treatment sequelae while preserving survival outcomes become of paramount importance. Here, we critically reviewed the evidence-based literature supporting the deintensification strategies in HPV-rela...
Source: Journal of Oncology - May 19, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Imaging Biomarkers as Predictors for Breast Cancer Death.
Conclusion: Combining imaging biomarkers such as the mammographic appearance of the tumor with the histopathologic distribution and basal phenotype, accurately predicted long-term risk of breast cancer death. The information may be relevant for determining the need for molecular testing, planning treatment, and determining the most appropriate clinical surveillance schedule for breast cancer patients. PMID: 31093281 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 18, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Immunotherapeutics in Multiple Myeloma: How Can Translational Mouse Models Help?
Authors: Cooke RE, Koldej R, Ritchie D Abstract Multiple myeloma (MM) is usually diagnosed in older adults at the time of immunosenescence, a collection of age-related changes in the immune system that contribute to increased susceptibility to infection and cancer. The MM tumor microenvironment and cumulative chemotherapies also add to defects in immunity over the course of disease. In this review we discuss how mouse models have furthered our understanding of the immune defects caused by MM and enabled immunotherapeutics to progress to clinical trials, but also question the validity of using immunodeficient models...
Source: Journal of Oncology - May 18, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Development and External Validation of Web-Based Models to Predict the Prognosis of Remnant Gastric Cancer after Surgery: A Multicenter Study.
Conclusions: The AJCC TNM staging system and the TRM staging system did not enable good distinction among the RGC patients. We have developed and validated visual web-based prediction models that are superior to these staging systems. PMID: 31093283 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 18, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis.
Authors: Trebinska-Stryjewska A, Szafron L, Rembiszewska A, Wakula M, Tabor S, Sienkiewicz R, Owczarek J, Balcerak A, Felisiak-Golabek A, Grzybowska EA Abstract HAX1 is an antiapoptotic factor involved in the regulation of cell migration and calcium homeostasis, overexpressed in several cancers, including breast cancer. It has been suggested that HAX1 is also implicated in metastasis. Herein we report the results of meta-analysis of HAX1 expression, based on publicly available data, which confirms its significant overexpression in breast cancer and demonstrates copy number gain and prognostic value of HAX1 overexpr...
Source: Journal of Oncology - May 18, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

GATA1 Promotes Gemcitabine Resistance in Pancreatic Cancer through Antiapoptotic Pathway.
Authors: Chang Z, Zhang Y, Liu J, Guan C, Gu X, Yang Z, Ye Q, Ding L, Liu R Abstract Gemcitabine-based chemotherapy is the first-line treatment for pancreatic cancer. However, chemoresistance is a major obstacle to drug efficacy, leading to poor prognosis. Little progress has been achieved although multiple mechanisms are investigated. Therefore, effective strategies are urgently needed to overcome drug resistance. Here, we demonstrate that the transcription factor GATA binding protein 1 (GATA1) promotes gemcitabine resistance in pancreatic cancer through antiapoptotic pathway. GATA1 is highly expressed in pancreat...
Source: Journal of Oncology - May 18, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Human Mitotic Centromere-Associated Kinesin Is Targeted by MicroRNA 485-5p/181c and Prognosticates Poor Survivability of Breast Cancer.
This study aims to evaluate the prognostic value of human Mitotic Centromere-Associated Kinesin (MCAK), a microtubule-dependent molecular motor, in breast cancers. The posttranscriptional regulation of MCAK by microRNAs will also be explored. Methods: The large-scale gene expression datasets of breast cancer (total n=4,677) were obtained from GEO, NKI, and TCGA database. Kaplan-Meier and Cox analyses were used for survival analysis. MicroRNAs targeting MCAK were predicted by bioinformatic analysis and validated by a dual-luciferase reporter assay. Results: The expression of MCAK was significantly associated with ag...
Source: Journal of Oncology - May 12, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Direct Genetics Referral Pathway for High-Grade Serous Ovarian Cancer Patients: The "Opt-Out" Process.
Conclusions: The opt-out referral process described in this study is s a feasible, effective, and patient-centred approach to increase access to BRCA1/2 testing for patients with ovarian cancer. PMID: 31061661 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 9, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Interfering Expression of Chimeric Transcript SEPT7P2-PSPH Promotes Cell Proliferation in Patients with Nasopharyngeal Carcinoma.
Conclusions: Our findings indicate that the chimeric transcript SEPT7P2-PSPH is a product of trans-splicing of two adjacent genes and might be a tumor suppressor gene, potentially having the role of anticancer activity. PMID: 31057610 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 8, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Targeting V-ATPase Isoform Restores Cisplatin Activity in Resistant Ovarian Cancer: Inhibition of Autophagy, Endosome Function, and ERK/MEK Pathway.
Authors: Kulshrestha A, Katara GK, Ibrahim SA, Riehl V, Sahoo M, Dolan J, Meinke KW, Pins MR, Beaman KD Abstract Ovarian cancer (OVCA) patients often develop tolerance to standard platinum therapy that accounts for extensive treatment failures. Cisplatin resistant OVCA cells (cis-R) display enhanced survival mechanisms to cope with therapeutic stress. In these cells, increased autophagy process assists in chemoresistance by boosting the nutrient pool under stress. To improve the treatment response, both protective autophagy inhibition and its overactivation are showing efficacy in chemosensitization. Autophagy requ...
Source: Journal of Oncology - May 8, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Association of NEFL Gene Polymorphisms with Wilms' Tumor Susceptibility in Chinese Children.
Authors: Jia W, Zhu J, Fu W, Zhu S, Deng F, Xia H, Liu GC, He J Abstract Wilms' tumor is renal tumor of childhood, characterized by the appearance of embryonic renal tissue and other kidney malformations. The genetic etiology of sporadic Wilms' tumor remains largely unknown. Neurofilament light (NEFL) is a tumor suppressor. We evaluated the association between three NEFL gene polymorphisms (rs11994014 G>A, rs2979704 T>C and rs1059111 A>T) and Wilms' tumor susceptibility in a Chinese population consisting of 145 cases and 531 controls. In the single locus analysis, rs2979704 CC variant genotype was associat...
Source: Journal of Oncology - May 8, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Molecular Drivers of Potential Immunotherapy Failure in Adrenocortical Carcinoma.
Authors: Fiorentini C, Grisanti S, Cosentini D, Abate A, Rossini E, Berruti A, Sigala S Abstract Adrenocortical carcinoma (ACC) is a rare, highly aggressive cancer, often insensitive to conventional chemotherapeutics agents. Early diagnosis, followed by radical surgical resection plus/minus adjuvant mitotane therapy, is nowadays the only valuable option. Unfortunately, one out of four patients has metastatic disease at diagnosis and most of radically resected ACC patients are destined to recur with local or metastatic disease. Numerous efforts aimed at identifying molecular alterations crucial for ACC pathogenesis ...
Source: Journal of Oncology - May 8, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer.
Authors: Aguilar-Medina M, Avendaño-Félix M, Lizárraga-Verdugo E, Bermúdez M, Romero-Quintana JG, Ramos-Payan R, Ruíz-García E, López-Camarillo C Abstract Transcriptional and epigenetic embryonic programs can be reactivated in cancer cells. As result, a specific subset of undifferentiated cells with stem-cells properties emerges and drives tumorigenesis. Recent findings have shown that ectoderm- and endoderm-derived tissues continue expressing stem-cells related transcription factors of the SOX-family of proteins such as SOX2 and SOX9 which have been implicated in th...
Source: Journal of Oncology - May 8, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Current Status of Immunotherapy for Localized and Locally Advanced Renal Cell Carcinoma.
This article reviews the current status and future prospects of adjuvant and neoadjuvant immunotherapy in localized and locally advanced RCC. PMID: 31057615 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 8, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Relationship between Upper Extremity Lymphatic Drainage and Sentinel Lymph Nodes in Patients with Breast Cancer.
Conclusions: The ARM nodes and SLNs are closely related and share lymphatic drainage routes. The ARM procedure using fluorescence imaging is both feasible and, in patients who are SLN negative, oncologically safe. ARM using ICG is therefore effective for identifying and preserving upper extremity lymphatics, and SLNB combined with ARM appears to be a promising surgical refinement for preventing upper extremity lymphoedema. Clinical Trial Registration: This trial is registered with ClinicalTrial.gov: NCT02651142. PMID: 31057616 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 8, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Risk Prediction for Contrast-Induced Nephropathy in Cancer Patients Undergoing Computed Tomography under Preventive Measures.
Authors: Jeon J, Kim S, Yoo H, Kim K, Kim Y, Park S, Jang HR, Kim DK, Huh W, Kim YG, Kim DJ, Oh HY, Lee JE Abstract Background: Contrast-induced nephropathy (CIN) is a major cause of acute kidney injury in chronic kidney disease. Many cancer patients have risk factors for CIN and frequently undergo contrast-enhanced computed tomography (CECT). We aimed to develop a risk prediction model for CIN in cancer patients undergoing CECT. Methods: Between 2009 and 2017, 2,240 cancer patients with estimated glomerular filtration rate (eGFR)
Source: Journal of Oncology - May 8, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

GASC1 Promotes Stemness of Esophageal Squamous Cell Carcinoma via NOTCH1 Promoter Demethylation.
This study aimed to reveal the effect and mechanism of GASC1 on ESCC stemness. The biological function of GASC1 in ESCC was evaluated both in vitro and in vivo. ChIP assay was performed to determine the molecular mechanism of GASC1 in epigenetic regulation of NOTCH1. We found that GASC1 expression was increased in poor differentiated ESCC cells and tissues. ESCC patients with a high level of GASC1 presented a significantly worse survival rate. GASC1 expression in purified ALDH+ ESCC cells was significantly higher than that in ALDH- cells. The stemness of ESCC was dramatically decreased after GASC1 blockade. Furthermore, bl...
Source: Journal of Oncology - May 1, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review.
Authors: Roslan Z, Muhamad M, Selvaratnam L, Ab-Rahim S Abstract Low-density lipoprotein receptor (LDLR) has been an object of research since the 1970s because of its role in various cell functions. The LDLR family members include LRP5, LRP6, and LRP8. Even though LRP5, 6, and 8 are in the same family, intriguingly, these three proteins have various roles in physiological events, as well as in regulating different mechanisms in various kinds of cancers. LRP5, LRP6, and LRP8 have been shown to play important roles in a broad panel of cancers. LRP5 is highly expressed in many tissues and is involved in the modulation...
Source: Journal of Oncology - May 1, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Synthetic House-Tree-Person Drawing Test: A New Method for Screening Anxiety in Cancer Patients.
Authors: Sheng L, Yang G, Pan Q, Xia C, Zhao L Abstract The synthetic house-tree-person (S-HTP) drawing test is a projective measure primarily designed to assess specific complex personality traits. It is widely used in general psychological problems and mental illness such as psychological crisis intervention. Applicability and validity of S-HTP drawing test in cancer patients suffering from anxiety are still unclear and there are no reports on such research. The aim of this study was to explore the prevalence of anxiety in cancer patients and to investigate the applicability of S-HTP drawing test in such patients...
Source: Journal of Oncology - May 1, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Development and Validation of the Dietary Habits and Colon Cancer Beliefs Survey (DHCCBS): An Instrument Assessing Health Beliefs Related to Red Meat and Green Leafy Vegetable Consumption.
Conclusion. The DHCCBS is a valid instrument for measuring health beliefs related to red meat, green leafy vegetables, and perceived colon cancer risk. Additionally, these findings suggest increasing GLV may be more feasible than reducing RM for CC risk reduction in meat eaters. PMID: 31015832 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - April 26, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Comparative Efficacy and Tolerability of Neoadjuvant Immunotherapy Regimens for Patients with HER2-Positive Breast Cancer: A Network Meta-Analysis.
In conclusion, our findings support CTP as the optimum neoadjuvant regimen for HER2-positive breast cancer, with the best pCR and acceptable toxicity compared with CT. MP provides a therapeutic option for patients with poor performance status. PMID: 31015833 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - April 26, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Characteristics of Mammographic Breast Density and Associated Factors for Chinese Women: Results from an Automated Measurement.
This study aims to identify factors associated with mammographic density in China using a quantitative method. Methods: Mammographic density was measured for a total of 1071 (84 with and 987 without breast cancer) women using an automatic algorithm AutoDensity. Pearson tests examined relationships between density and continuous variables and t-tests compared differences of mean density values between groupings of categorical variables. Linear models were built using multiple regression. Results: Percentage density and dense area were positively associated with each other for cancer-free (r=0.487, p
Source: Journal of Oncology - April 26, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience.
Authors: Simsek C, Esin E, Yalcin S Abstract Metronomic chemotherapy, continuous and dose-dense administration of chemotherapeutic drugs with lowered doses, is being evaluated for substituting, augmenting, or appending conventional maximum tolerated dose regimens, with preclinical and clinical studies for the past few decades. To date, the principle mechanisms of its action include impeding tumoral angiogenesis and modulation of hosts' immune system, affecting directly tumor cells, their progenitors, and neighboring stromal cells. Its better toxicity profile, lower cost, and easier use are main advantages over conv...
Source: Journal of Oncology - April 26, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue.
Authors: Ayers D, Boughanem H, Macías-González M Abstract The World Health Organization (WHO) considers that obesity has reached proportions of pandemic. Experts also insist on the importance of considering obesity as a chronic disease and one of the main contributors to the worldwide burden of other nontransmissible chronic diseases, which have a great impact on health, lifestyle, and economic cost. One of the most current challenges of biomedical science faces is to understand the origin of the chronic nontransmissible diseases, such as obesity and cancer. There is a large evidence, both in epidemio...
Source: Journal of Oncology - April 23, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

The Significant Influence of the Neuroendocrine Component on the Survival of Patients with Gastric Carcinoma Characterized by Coexisting Exocrine and Neuroendocrine Components.
Authors: Ren H, Shi SS, Wang NC, Wang X, Chen YT, Zhao DB Abstract Background: Gastric adenocarcinoma patients with a neuroendocrine (NE) component are frequently observed in routine practice. Several previous studies have investigated the influence of a NE component on the survival of these patients; however, the results were inconsistent. Methods: We retrospectively investigated a consecutive series of 95 gastric adenocarcinoma patients with a NE component and 190 gastric adenocarcinoma patients without a NE component. We adopted 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, and 90% as the cut-off proportions of th...
Source: Journal of Oncology - April 19, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

The Impact of Addition of Consolidation Chemotherapy to Standard Cisplatin-Based Chemoradiotherapy in Uterine Cervical Cancer: Matter of Distant Relapse.
Conclusions: Use of consolidation CT resulted in longer OS and PFS, mostly due to control of distant relapses. Patients at higher risk of distant relapse showed the greatest benefit. This data generates a hypothesis that could help to better select patients to consolidation CT. PMID: 30984261 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - April 16, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Clinical Spectrum of Complications Induced by Intravesical Immunotherapy of Bacillus Calmette-Gu érin for Bladder Cancer.
Clinical Spectrum of Complications Induced by Intravesical Immunotherapy of Bacillus Calmette-Guérin for Bladder Cancer. J Oncol. 2019;2019:6230409 Authors: Liu Y, Lu J, Huang Y, Ma L Abstract Because of its proven efficacy, intravesical Bacillus Calmette-Guérin (BCG) immunotherapy is an important treatment for nonmuscle invasive bladder cancer at high risk of recurrence or progression. However, approximately 8% of patients have to stop BCG instillation as a result of its complications. Complications induced by BCG therapy can have a variety of clinical manifestations. These adverse react...
Source: Journal of Oncology - April 16, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Tubal Origin of "Ovarian" Low-Grade Serous Carcinoma: A Gene Expression Profile Study.
Conclusions: This study provides evidence in a molecular level that ovarian low-grade serous carcinomas likely originate from the fallopian tube rather than from ovarian surface epithelia. Similar gene expression profiles among fallopian tube, ovarian epithelial inclusions, and serous tumors further support that ovarian low-grade serous carcinomas develop in a stepwise fashion. Such findings may have a significant implication for "ovarian" cancer-prevention strategies. PMID: 30949203 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - April 6, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

EF24 Suppresses Cholangiocellular Carcinoma Progression, Inhibits STAT3 Phosphorylation, and Induces Apoptosis via ROS-Mediated Oxidative Stress.
This study provides preclinical experimental evidence of therapeutic activity of the curcumin analog EF24 in cholangiocarcinoma models. In CCC cell lines, EF24 inhibited cell viability and induced apoptosis through excessive ROS generation. Moreover, administration of EF24 led to depletion of total intracellular GSH levels, induced mitochondrial depolarization, and abrogated STAT3 phosphorylation. Of interest, these effects were readily averted by treating the cells with exogenous antioxidants such as N-acetyl cysteine (NAC) or glutathione monoethyl ester (GEE). In vivo, EF24, solubilized using a cyclodextrin formulation, ...
Source: Journal of Oncology - April 6, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research