DNAJA1 Stabilizes EF1A1 to Promote Cell Proliferation and Metastasis of Liver Cancer Mediated by miR-205-5p
In conclusion, our study reveals that DNAJA1 acts as an oncogene in liver cancer via miR-205-5p/EF1A1 axis and might be a potential biomarker to predict the prognosis for liver cancer patients.PMID:35586205 | PMC:PMC9110222 | DOI:10.1155/2022/2292481 (Source: Journal of Oncology)
Source: Journal of Oncology - May 19, 2022 Category: Cancer & Oncology Authors: Lizhi Yi Shunhui He Zhengyu Cheng Xi Chen Xiaoli Ren Yang Bai Source Type: research

HOTAIRM1 Maintained the Malignant Phenotype of tMSCs Transformed by GSCs via E2F7 by Binding to FUS
CONCLUSION: Our study revealed that the HOTAIRM1/FUS/E2F7 axis is involved in the malignant progression of tMSCs transformed by GSCs in the glioma microenvironment and may function as a novel target for glioma therapy.PMID:35586206 | PMC:PMC9110228 | DOI:10.1155/2022/7734413 (Source: Journal of Oncology)
Source: Journal of Oncology - May 19, 2022 Category: Cancer & Oncology Authors: Liang Liu Yanling Zhou Xuchen Dong Suwen Li Shan Cheng Haoran Li Yongdong Li Jiaqi Yuan Liping Wang Jun Dong Source Type: research

Nonpolypous Hamartomas of the Gastrointestinal Tract: An Updated Review on Classification, Denominations, and Clinical Management
CONCLUSION: Even rare, hamartomas of the GI tract need to be differentiated from tumors and familial polyposis syndromes. Knowing their proper denominations and possible complications is valuable for gastroenterologists, pathologists, and surgeons, to be aware in the differential diagnosis.PMID:35586207 | PMC:PMC9110201 | DOI:10.1155/2022/6983460 (Source: Journal of Oncology)
Source: Journal of Oncology - May 19, 2022 Category: Cancer & Oncology Authors: Simona Gurzu Diana Burlacu Ioan Jung Source Type: research

Metabolism-Related Bioinformatics Analysis Reveals That HPRT1 Facilitates the Progression of Oral Squamous Cell Carcinoma In Vitro
CONCLUSIONS: MRGs play an important role in the development of OSCC. Furthermore, HPRT1 might be an independent biomarker of OSCC and enhance OSCC proliferation, migration, and invasion in vitro; these results emphasize the potential utility of HPRT1 in OSCC therapy.PMID:35586208 | PMC:PMC9110220 | DOI:10.1155/2022/7453185 (Source: Journal of Oncology)
Source: Journal of Oncology - May 19, 2022 Category: Cancer & Oncology Authors: Hengyu Ye Zenan Zheng Yuxing Song Guangzhao Huang Qingqing Wu Yilong Ai Xiaozhi Lv Source Type: research

Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors
J Oncol. 2022 May 9;2022:3249766. doi: 10.1155/2022/3249766. eCollection 2022.ABSTRACTCancer is one of the major causes of death worldwide. Its treatments usually fail when the tumor has become malignant and metastasized. Metastasis is a key source of cancer recurrence, which often leads to resistance towards chemotherapeutic agents. Hence, most cancer-related deaths are linked to the occurrence of chemoresistance. Although chemoresistance can emerge through a multitude of mechanisms, chemoresistance and metastasis share a similar pathway, which is an epithelial-to-mesenchymal transition (EMT). Matrix metalloproteinases (M...
Source: Journal of Oncology - May 19, 2022 Category: Cancer & Oncology Authors: Bernadette Xin Jie Tune Maw Shin Sim Chit Laa Poh Rhanye Mac Guad Choy Ker Woon Iswar Hazarika Anju Das Subash C B Gopinath Mariappan Rajan Mahendran Sekar Vetriselvan Subramaniyan Neeraj Kumar Fuloria Shivkanya Fuloria Kalaivani Batumalaie Yuan Seng Wu Source Type: research

DNAJA1 Stabilizes EF1A1 to Promote Cell Proliferation and Metastasis of Liver Cancer Mediated by miR-205-5p
In conclusion, our study reveals that DNAJA1 acts as an oncogene in liver cancer via miR-205-5p/EF1A1 axis and might be a potential biomarker to predict the prognosis for liver cancer patients.PMID:35586205 | PMC:PMC9110222 | DOI:10.1155/2022/2292481 (Source: Journal of Oncology)
Source: Journal of Oncology - May 19, 2022 Category: Cancer & Oncology Authors: Lizhi Yi Shunhui He Zhengyu Cheng Xi Chen Xiaoli Ren Yang Bai Source Type: research

HOTAIRM1 Maintained the Malignant Phenotype of tMSCs Transformed by GSCs via E2F7 by Binding to FUS
CONCLUSION: Our study revealed that the HOTAIRM1/FUS/E2F7 axis is involved in the malignant progression of tMSCs transformed by GSCs in the glioma microenvironment and may function as a novel target for glioma therapy.PMID:35586206 | PMC:PMC9110228 | DOI:10.1155/2022/7734413 (Source: Journal of Oncology)
Source: Journal of Oncology - May 19, 2022 Category: Cancer & Oncology Authors: Liang Liu Yanling Zhou Xuchen Dong Suwen Li Shan Cheng Haoran Li Yongdong Li Jiaqi Yuan Liping Wang Jun Dong Source Type: research

Nonpolypous Hamartomas of the Gastrointestinal Tract: An Updated Review on Classification, Denominations, and Clinical Management
CONCLUSION: Even rare, hamartomas of the GI tract need to be differentiated from tumors and familial polyposis syndromes. Knowing their proper denominations and possible complications is valuable for gastroenterologists, pathologists, and surgeons, to be aware in the differential diagnosis.PMID:35586207 | PMC:PMC9110201 | DOI:10.1155/2022/6983460 (Source: Journal of Oncology)
Source: Journal of Oncology - May 19, 2022 Category: Cancer & Oncology Authors: Simona Gurzu Diana Burlacu Ioan Jung Source Type: research

Metabolism-Related Bioinformatics Analysis Reveals That HPRT1 Facilitates the Progression of Oral Squamous Cell Carcinoma In Vitro
CONCLUSIONS: MRGs play an important role in the development of OSCC. Furthermore, HPRT1 might be an independent biomarker of OSCC and enhance OSCC proliferation, migration, and invasion in vitro; these results emphasize the potential utility of HPRT1 in OSCC therapy.PMID:35586208 | PMC:PMC9110220 | DOI:10.1155/2022/7453185 (Source: Journal of Oncology)
Source: Journal of Oncology - May 19, 2022 Category: Cancer & Oncology Authors: Hengyu Ye Zenan Zheng Yuxing Song Guangzhao Huang Qingqing Wu Yilong Ai Xiaozhi Lv Source Type: research

Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors
J Oncol. 2022 May 9;2022:3249766. doi: 10.1155/2022/3249766. eCollection 2022.ABSTRACTCancer is one of the major causes of death worldwide. Its treatments usually fail when the tumor has become malignant and metastasized. Metastasis is a key source of cancer recurrence, which often leads to resistance towards chemotherapeutic agents. Hence, most cancer-related deaths are linked to the occurrence of chemoresistance. Although chemoresistance can emerge through a multitude of mechanisms, chemoresistance and metastasis share a similar pathway, which is an epithelial-to-mesenchymal transition (EMT). Matrix metalloproteinases (M...
Source: Journal of Oncology - May 19, 2022 Category: Cancer & Oncology Authors: Bernadette Xin Jie Tune Maw Shin Sim Chit Laa Poh Rhanye Mac Guad Choy Ker Woon Iswar Hazarika Anju Das Subash C B Gopinath Mariappan Rajan Mahendran Sekar Vetriselvan Subramaniyan Neeraj Kumar Fuloria Shivkanya Fuloria Kalaivani Batumalaie Yuan Seng Wu Source Type: research

NF- < em > κ < /em > B-Activated lncRNACASC9 Promotes Bladder Cancer Progression by Regulating the TK1 Expression
In this study, we identified lncRNAs that were abnormally expressed in bladder cancer. We found that lncRNACASC9 plays an important role in the progression of bladder cancer. CASC9 was highly expressed in bladder cancer cells and tissues, and the prognosis of bladder cancer patients with high expression of CASC9 was poor. The results of colony formation assays, CCK-8 assays, EdU assays, transwell assays, mouse xenograft models, and tail vein injection lung metastasis model showed that CASC9 could promote bladder cancer cells growth and metastasis both in vitro and in vivo. Mechanistically, through FISH experiments, lucifer...
Source: Journal of Oncology - May 17, 2022 Category: Cancer & Oncology Authors: Cai Longjun Zhang Jianjun Pang Kun Hao Lin Shi Zhenduo Dong Yang Li Bibo Zhang Zhiguo Li Rui Han Conghui Source Type: research

AHCYL1 Is a Novel Biomarker for Predicting Prognosis and Immunotherapy Response in Colorectal Cancer
CONCLUSION: For CRC patients, the prognostic model based on AHCYL1 and AHCYL1-related genes showed a high predictive performance in terms of prognosis and immunotherapy response.PMID:35578598 | PMC:PMC9107370 | DOI:10.1155/2022/5054324 (Source: Journal of Oncology)
Source: Journal of Oncology - May 17, 2022 Category: Cancer & Oncology Authors: Xubin Li Mengqiao Zhang Xue Yu Mei Xue Xiaowei Li Chao Ma Wei Jia Qiang Gao Chunbo Kang Source Type: research

PITPNA-AS1/miR-98-5p to Mediate the Cisplatin Resistance of Gastric Cancer
In this study, we employ noncoding RNA sequencing and found that lncRNA PITPNA-AS1 is overexpressed in gastric cancer tissues and associated with poor survival of gastric cancer patients. Kockdown of PITPNA-AS1 in gastric cancer cells significantly inhibited cell growth and triggered apoptotic cell death in gastric cancer cells. Also, cisplatin treatment could decrease PITPNA-AS1 levels in gastric cancer cells through inhibiting H3K27ac. Besides, PITPNA-AS1 is elevated in cisplatin-resistant gastric cancer cells and tissues, PITPNA-AS1 knockdown could sensitize gastric cancer cells to cisplatin treatment. Furthermore, we i...
Source: Journal of Oncology - May 17, 2022 Category: Cancer & Oncology Authors: Zhongling Ma Gang Liu Suhong Hao Tianfu Zhao Wei Chang Jiansheng Wang Hong Ren Xinhan Zhao Source Type: research

A Pan-Cancer Analysis of UBE2S in Tumorigenesis, Prognosis, Pathway, Immune Infiltration and Evasion, and Therapy Response from an Immune-Oncology Perspective
CONCLUSIONS: Our study provided meaningful clues to support UBE2S as an immune-oncogenic molecule and shed light on potential applications of UBE2S in cancer detection, prognostic prediction, and therapeutic response assessment.PMID:35578600 | PMC:PMC9107357 | DOI:10.1155/2022/3982539 (Source: Journal of Oncology)
Source: Journal of Oncology - May 17, 2022 Category: Cancer & Oncology Authors: Haili Bao Yi Luo Guoshan Ding Zhiren Fu Source Type: research

NF- < em > κ < /em > B-Activated lncRNACASC9 Promotes Bladder Cancer Progression by Regulating the TK1 Expression
In this study, we identified lncRNAs that were abnormally expressed in bladder cancer. We found that lncRNACASC9 plays an important role in the progression of bladder cancer. CASC9 was highly expressed in bladder cancer cells and tissues, and the prognosis of bladder cancer patients with high expression of CASC9 was poor. The results of colony formation assays, CCK-8 assays, EdU assays, transwell assays, mouse xenograft models, and tail vein injection lung metastasis model showed that CASC9 could promote bladder cancer cells growth and metastasis both in vitro and in vivo. Mechanistically, through FISH experiments, lucifer...
Source: Journal of Oncology - May 17, 2022 Category: Cancer & Oncology Authors: Cai Longjun Zhang Jianjun Pang Kun Hao Lin Shi Zhenduo Dong Yang Li Bibo Zhang Zhiguo Li Rui Han Conghui Source Type: research