Molecular Insights into the Breast and Prostate Cancer Cells in Response to the Change of Extracellular Zinc
This study attempted to uncover the molecular details prodded by the change of extracellular zinc by employing a panel of normal and cancerous breast and prostate cell lines coupled with the top-down proteomics with two-dimensional gel electrophoresis followed by liquid chromatography-tandem mass spectrometry. The protein samples were generated from MCF-7 breast cancer cells, MCF10A normal breast cells, PC3 prostate cancer cells, and RWPE-1 normal prostate cells with or without exogenous zinc exposure in a time course (T0 and T120). By comparing the cancer cells vs respective normal epithelial cells without zinc treatment ...
Source: Journal of Oncology - January 22, 2024 Category: Cancer & Oncology Authors: Shital K Barman Monokesh K Sen David A Mahns Ming J Wu Chandra S Malladi Source Type: research