Neutrophil-to-Lymphocyte Ratio (NLR) and Monocyte-to-Lymphocyte Ratio (MLR) Predict Clinical Outcome in Patients with Stage IIB Cervical Cancer
CONCLUSIONS: For patients with stage IIB CC, both NLR and MLR are independent prognostic factors as well as risk factors for recurrence; NLR serves as a potential marker for therapeutic response.PMID:34539781 | PMC:PMC8443385 | DOI:10.1155/2021/2939162 (Source: Journal of Oncology)
Source: Journal of Oncology - September 20, 2021 Category: Cancer & Oncology Authors: Yong-Xia Li Jian-Ying Chang Ming-Yuan He He-Ran Wang Dai-Qin Luo Feng-Hu Li Jie-Hui Li Li Ran Source Type: research

HOTAIR Contributes to Stemness Acquisition of Cervical Cancer through Regulating miR-203 Interaction with ZEB1 on Epithelial-Mesenchymal Transition
J Oncol. 2021 Sep 10;2021:4190764. doi: 10.1155/2021/4190764. eCollection 2021.ABSTRACTCervical cancer stem cells contribute respond to considerable recurrence and metastasis of patients with cervical cancer. The stemness properties were partly regulated by the interaction of lncRNAs and miRNAs. HOTAIR functions as an oncogenic lncRNA. Previous research studies revealed its role in regulating stemness properties in various cancers. However, the role of HOTAIR in cervical cancer stem cells is still unknown. Here, cisplatin-resistant and serum-free cultured cells exhibited stem cells properties. Cervical cancer stem cells ex...
Source: Journal of Oncology - September 20, 2021 Category: Cancer & Oncology Authors: Wenying Zhang Jing Liu Qiongwei Wu Yu Liu Chengbin Ma Source Type: research

Identification of Differentially Expressed Circular RNAs as miRNA Sponges in Lung Adenocarcinoma
CONCLUSION: Our results indicated that 7 DEcircRNAs could have diagnostic value for LUAD. Additionally, the circRNAs-mediated ceRNA network might provide a novel perspective into unraveling the pathogenesis and progression of LUAD.PMID:34539783 | PMC:PMC8448594 | DOI:10.1155/2021/5193913 (Source: Journal of Oncology)
Source: Journal of Oncology - September 20, 2021 Category: Cancer & Oncology Authors: Yuechao Liu Xin Wang Lulu Bi Hongbo Huo Shi Yan Yimeng Cui Yaowen Cui Ruixue Gu Dexin Jia Shuai Zhang Li Cai Xiaomei Li Ying Xing Source Type: research

KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer
J Oncol. 2021 Sep 9;2021:5572402. doi: 10.1155/2021/5572402. eCollection 2021.ABSTRACTKIFs have been reported to play a critical role in a variety of tumors, and KIF20B is a protein in KFIs. In this research, KIF20B was highly expressed in the GEO database and our hospital's data, and high expression of KIF20B suggested poor prognosis. We detect the expression of KIF20B in pancreatic cancer and adjacent normal tissues using immunohistochemistry. Knockdown of KIF20B in pancreatic cancer cell lines, PANC-1 and BxPC-3 cells, inhibited cell proliferation which are detected by colony formation assays, CCK8, and western bolt of ...
Source: Journal of Oncology - September 20, 2021 Category: Cancer & Oncology Authors: Jing Chen Cui-Cui Zhao Fei-Ran Chen Guo-Wei Feng Fei Luo Tao Jiang Source Type: research

A Comprehensive Multiomics Analysis Identified Ubiquilin 4 as a Promising Prognostic Biomarker of Immune-Related Therapy in Pan-Cancer
In conclusion, UBQLN4 was a promising prognostic biomarker of immune-related therapy in pan-cancer.PMID:34539785 | PMC:PMC8443395 | DOI:10.1155/2021/7404927 (Source: Journal of Oncology)
Source: Journal of Oncology - September 20, 2021 Category: Cancer & Oncology Authors: Jie Li Ye Tong Zhi Wang Yi Liu Xiaobo Dai Yuxi Zhu Source Type: research

TLR3 Serves as a Prognostic Biomarker and Associates with Immune Infiltration in the Renal Clear Cell Carcinoma Microenvironment
CONCLUSION: Our results indicate that TLR3 serves as a prognostic biomarker and associated with immune infiltration in KIRC. This work lays a foundation for further studies on the role of TLR3 in the carcinogenesis and progression of KIRC.PMID:34531911 | PMC:PMC8440088 | DOI:10.1155/2021/3336770 (Source: Journal of Oncology)
Source: Journal of Oncology - September 17, 2021 Category: Cancer & Oncology Authors: Guodong Liao Jia Lv Alin Ji Shuai Meng Chao Chen Source Type: research

MiR-200b Suppresses Gastric Cancer Cell Migration and Invasion by Inhibiting NRG1 through ERBB2/ERBB3 Signaling
CONCLUSION: MiR-200b suppressed EMT-related migration and invasion of GC through the ERBB2/ERBB3 signaling pathway via targeting NRG1.PMID:34531912 | PMC:PMC8440071 | DOI:10.1155/2021/4470778 (Source: Journal of Oncology)
Source: Journal of Oncology - September 17, 2021 Category: Cancer & Oncology Authors: Tonglei Xu Fangliang Xie Dazhou Xu Weidong Xu Xuming Ge Shengxiang Lv Shouying Li Source Type: research

Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features
J Oncol. 2021 Sep 3;2021:3569349. doi: 10.1155/2021/3569349. eCollection 2021.ABSTRACTThe indiscriminate consumption of antimalarials against coronavirus disease-2019 emphasizes the longstanding clinical weapons of medicines. In this work, we conducted a review on the antitumor mechanisms of aminoquinolines, focusing on the responses and differences of tumor histological tissues and toxicity related to pharmacokinetics. This well-defined analysis shows similar mechanistic forms triggered by aminoquinolines in different histological tumor tissues and under coexposure conditions, although different pharmacological potencies ...
Source: Journal of Oncology - September 16, 2021 Category: Cancer & Oncology Authors: Paulo Michel Pinheiro Ferreira Jos é Roberto de Oliveira Ferreira Rayran Walter Ramos de Sousa Daniel Pereira Bezerra Gardenia Carmen Gadelha Milit ão Source Type: research

Combining Fluorescent Cell Sorting and Single B Cell Amplification to Screen the Monoclonal Antibody Gene against Human Glypican-1 in Pancreatic Cancer
In this report, one novel method has been developed to screen the monoclonal antibody against human pancreatic cancer biomarker glypican-1 (GPC1) through the combination of fluorescent cell sorting and single B cell amplification. GPC1-positive B cells were sorted out from the peripheral blood mononuclear cells (PBMCs) by fluorescent cell sorting after the GPC1 immunization to the New Zealand white rabbit. Then, total RNA was extracted and reversely transcribed into cDNA, which was used as the template, and the variable region sequences of both heavy and light chains were amplified from the same B cell. Next, their recombi...
Source: Journal of Oncology - September 16, 2021 Category: Cancer & Oncology Authors: Mi Huang Yingying Ma Xiaoyan Gao Xinyang Li Quan Ding Chuxin Liu Xiaopan Liu Hang Zhang Naibo Yang Source Type: research

Clinical Profile and Treatment Outcomes in Patients Treated with Intensity-Modulated Radiotherapy (IMRT) for Carcinoma Nasopharynx: A Retrospective Analysis
CONCLUSION: The present study shows our initial experience with IMRT for nasopharyngeal carcinoma. The compliance to RT was good in this study. The 5-year LRC and OS rate of nasopharyngeal carcinoma patients treated with IMRT were 87.5% and 62.5%. Distant metastasis was the main pattern of failure.PMID:34527052 | PMC:PMC8437612 | DOI:10.1155/2021/9932749 (Source: Journal of Oncology)
Source: Journal of Oncology - September 16, 2021 Category: Cancer & Oncology Authors: Farida Nazeer R Rejnish Kumar Malu Rafi Tapesh Bhattacharya Aparna Mullangath Prakasan Kumar P Naveen Preethi George Ramadas Kunnambath Kainickal Cessal Thommachan Source Type: research

Application of NRS2002 in Preoperative Nutritional Screening for Patients with Liver Cancer
J Oncol. 2021 Aug 27;2021:8943353. doi: 10.1155/2021/8943353. eCollection 2021.ABSTRACTOBJECTIVE: To explore the application of NRS2002 in preoperative nutritional screening of patients with liver cancer (LC).METHODS: 60 LC patients treated in the First Affiliated Hospital of Gannan Medical University (January 2018-May 2021) were chosen as the research objects, and split into group J without nutritional risk and group Q with nutritional risk according to the results of NRS2002 to compare the preoperative situation, surgery-related indexes, hematological indexes, postoperative recovery, and incidence of complications betwee...
Source: Journal of Oncology - September 14, 2021 Category: Cancer & Oncology Authors: Suling Huang Shijie Wang Yuankang Xie Xiao He Xiuying Yi Jianhong Zhang Zuomei Deng Ling Yin Source Type: research

LncRNA NKILA Promotes Epithelial-Mesenchymal Transition of Liver Cancer Cells by Targeting miR-485-5p
J Oncol. 2021 Sep 3;2021:1281031. doi: 10.1155/2021/1281031. eCollection 2021.ABSTRACTOBJECTIVE: Liver cancer (LC), one of the familiar malignancies, has a very high morbidity all over the world. The onset of the disease is hidden, and the patients usually do not express any special symptoms. Most of them will have been developed to the middle and later stage when they are diagnosed. This is one of the main reasons why the prognosis of LC is extremely pessimistic all the year round. Recently, researchers have focused mainly on molecular studies, among which LncRNA is a hot spot. This research aims to explore the biological...
Source: Journal of Oncology - September 13, 2021 Category: Cancer & Oncology Authors: Yuxu Wang Chao Li Yuyi Shi Jing Kuai Source Type: research

High Expression of ROMO1 Aggravates the Malignancy of Hepatoblastoma
In conclusion, upregulation of ROMO1 promotes tumor growth and cell aggressiveness in HB.PMID:34512752 | PMC:PMC8426091 | DOI:10.1155/2021/2341719 (Source: Journal of Oncology)
Source: Journal of Oncology - September 13, 2021 Category: Cancer & Oncology Authors: Jiangfeng Lv Yan Wu Wei Li Huaping Fan Source Type: research

LncRNA SNHG7 Regulates Gastric Cancer Progression by miR-485-5p
CONCLUSIONS: SNHG7 knockdown could hamper gastric cancer progression via inhibiting miR-485-5p expression, providing a novel understanding for gastric cancer development.PMID:34512753 | PMC:PMC8424243 | DOI:10.1155/2021/6147962 (Source: Journal of Oncology)
Source: Journal of Oncology - September 13, 2021 Category: Cancer & Oncology Authors: Zhongsong Zhao Xueping Liu Source Type: research

Involvement of < em > TRPC7-AS1 < /em > Expression in Hepatitis B Virus-Related Hepatocellular Carcinoma
CONCLUSION: TRP superfamily genes, especially TRPC7-AS1, were highly expressed in HBV-related HCC. TRPC7-AS1 could be a potential therapeutic target or diagnostic marker for HCC.PMID:34512754 | PMC:PMC8426092 | DOI:10.1155/2021/8114327 (Source: Journal of Oncology)
Source: Journal of Oncology - September 13, 2021 Category: Cancer & Oncology Authors: Shaoliang Zhu Hang Ye Xiaojie Xu Weiru Huang Ziyu Peng Yingyang Liao Ningfu Peng Source Type: research

Circular RNA hsa_circ_0006117 Facilitates Pancreatic Cancer Progression by Regulating the miR-96-5p/KRAS/MAPK Signaling Pathway
J Oncol. 2021 Sep 2;2021:9213205. doi: 10.1155/2021/9213205. eCollection 2021.ABSTRACTCircular RNAs (circRNAs) play key roles in many malignant tumors, including pancreatic cancer (PC); however, whether circular RNA hsa_circ_0006117, a newly identified circRNA, has a role in PC has not been investigated. Here, in order to elucidate the role and potential molecular mechanisms of circRNAs, we utilized bioinformatic tolls to screen the differentially expressed circRNAs in PC. Subsequently, circular RNA hsa_circ_0006117 was identified as being highly expressed in PC tissues in a screen of two GEO datasets, which was further ve...
Source: Journal of Oncology - September 13, 2021 Category: Cancer & Oncology Authors: Tao Liu Lei Zhou Zhiwei He Yankun Chen Xueyi Jiang Jian Xu Jianxin Jiang Source Type: research

LncRNA NKILA Promotes Epithelial-Mesenchymal Transition of Liver Cancer Cells by Targeting miR-485-5p
J Oncol. 2021 Sep 3;2021:1281031. doi: 10.1155/2021/1281031. eCollection 2021.ABSTRACTOBJECTIVE: Liver cancer (LC), one of the familiar malignancies, has a very high morbidity all over the world. The onset of the disease is hidden, and the patients usually do not express any special symptoms. Most of them will have been developed to the middle and later stage when they are diagnosed. This is one of the main reasons why the prognosis of LC is extremely pessimistic all the year round. Recently, researchers have focused mainly on molecular studies, among which LncRNA is a hot spot. This research aims to explore the biological...
Source: Journal of Oncology - September 13, 2021 Category: Cancer & Oncology Authors: Yuxu Wang Chao Li Yuyi Shi Jing Kuai Source Type: research

High Expression of ROMO1 Aggravates the Malignancy of Hepatoblastoma
In conclusion, upregulation of ROMO1 promotes tumor growth and cell aggressiveness in HB.PMID:34512752 | PMC:PMC8426091 | DOI:10.1155/2021/2341719 (Source: Journal of Oncology)
Source: Journal of Oncology - September 13, 2021 Category: Cancer & Oncology Authors: Jiangfeng Lv Yan Wu Wei Li Huaping Fan Source Type: research

LncRNA SNHG7 Regulates Gastric Cancer Progression by miR-485-5p
CONCLUSIONS: SNHG7 knockdown could hamper gastric cancer progression via inhibiting miR-485-5p expression, providing a novel understanding for gastric cancer development.PMID:34512753 | PMC:PMC8424243 | DOI:10.1155/2021/6147962 (Source: Journal of Oncology)
Source: Journal of Oncology - September 13, 2021 Category: Cancer & Oncology Authors: Zhongsong Zhao Xueping Liu Source Type: research

Involvement of < em > TRPC7-AS1 < /em > Expression in Hepatitis B Virus-Related Hepatocellular Carcinoma
CONCLUSION: TRP superfamily genes, especially TRPC7-AS1, were highly expressed in HBV-related HCC. TRPC7-AS1 could be a potential therapeutic target or diagnostic marker for HCC.PMID:34512754 | PMC:PMC8426092 | DOI:10.1155/2021/8114327 (Source: Journal of Oncology)
Source: Journal of Oncology - September 13, 2021 Category: Cancer & Oncology Authors: Shaoliang Zhu Hang Ye Xiaojie Xu Weiru Huang Ziyu Peng Yingyang Liao Ningfu Peng Source Type: research

Circular RNA hsa_circ_0006117 Facilitates Pancreatic Cancer Progression by Regulating the miR-96-5p/KRAS/MAPK Signaling Pathway
J Oncol. 2021 Sep 2;2021:9213205. doi: 10.1155/2021/9213205. eCollection 2021.ABSTRACTCircular RNAs (circRNAs) play key roles in many malignant tumors, including pancreatic cancer (PC); however, whether circular RNA hsa_circ_0006117, a newly identified circRNA, has a role in PC has not been investigated. Here, in order to elucidate the role and potential molecular mechanisms of circRNAs, we utilized bioinformatic tolls to screen the differentially expressed circRNAs in PC. Subsequently, circular RNA hsa_circ_0006117 was identified as being highly expressed in PC tissues in a screen of two GEO datasets, which was further ve...
Source: Journal of Oncology - September 13, 2021 Category: Cancer & Oncology Authors: Tao Liu Lei Zhou Zhiwei He Yankun Chen Xueyi Jiang Jian Xu Jianxin Jiang Source Type: research

Developing ZNF Gene Signatures Predicting Radiosensitivity of Patients with Breast Cancer
This study aimed to explore the relationship between the expression of zinc finger (ZNF) gene family proteins and the radiosensitivity of breast cancer patients. Clinical and gene expression data on a total of 976 breast cancer samples were obtained from The Cancer Genome Atlas (TCGA) database. ZNF gene expression was dichotomized into groups with a higher or lower level than the median level of expression. Univariate and multivariate Cox regression analyses were used to evaluate the relationship between ZNF gene expression levels and radiosensitivity. The Molecular Taxonomy Data of the International Federation of Breast C...
Source: Journal of Oncology - September 10, 2021 Category: Cancer & Oncology Authors: Derui Yan Mingjing Shen Zixuan Du Jianping Cao Ye Tian Ping Zeng Zaixiang Tang Source Type: research

The Indication of Poor Prognosis by High Expression of ENO1 in Squamous Cell Carcinoma of the Lung
J Oncol. 2021 Aug 30;2021:9910962. doi: 10.1155/2021/9910962. eCollection 2021.ABSTRACTThe purpose of this study is to investigate the significance of alpha-enolase (ENO1) expression in squamous cell carcinoma of the lung (LUSC), its prognostic value, and prospective molecular mechanism. Using multiplatforms data, including in-house immunohistochemistry, in-house real-time fluorescence quantitative polymerase chain reaction (RT-qPCR), in-house microarray, and public high-throughput data, the expression significance and prognostic role of ENO1 in LUSC tissues were analyzed comprehensively. With the combination of all eligib...
Source: Journal of Oncology - September 10, 2021 Category: Cancer & Oncology Authors: Wan-Ying Huang Gang Chen Shang-Wei Chen Yi-Wu Dang Yun Deng Hua-Fu Zhou Jin-Liang Kong Yu Zhang Jun-Xian Mo Chang-Bo Li Juan He Source Type: research

Developing ZNF Gene Signatures Predicting Radiosensitivity of Patients with Breast Cancer
This study aimed to explore the relationship between the expression of zinc finger (ZNF) gene family proteins and the radiosensitivity of breast cancer patients. Clinical and gene expression data on a total of 976 breast cancer samples were obtained from The Cancer Genome Atlas (TCGA) database. ZNF gene expression was dichotomized into groups with a higher or lower level than the median level of expression. Univariate and multivariate Cox regression analyses were used to evaluate the relationship between ZNF gene expression levels and radiosensitivity. The Molecular Taxonomy Data of the International Federation of Breast C...
Source: Journal of Oncology - September 10, 2021 Category: Cancer & Oncology Authors: Derui Yan Mingjing Shen Zixuan Du Jianping Cao Ye Tian Ping Zeng Zaixiang Tang Source Type: research

The Indication of Poor Prognosis by High Expression of ENO1 in Squamous Cell Carcinoma of the Lung
J Oncol. 2021 Aug 30;2021:9910962. doi: 10.1155/2021/9910962. eCollection 2021.ABSTRACTThe purpose of this study is to investigate the significance of alpha-enolase (ENO1) expression in squamous cell carcinoma of the lung (LUSC), its prognostic value, and prospective molecular mechanism. Using multiplatforms data, including in-house immunohistochemistry, in-house real-time fluorescence quantitative polymerase chain reaction (RT-qPCR), in-house microarray, and public high-throughput data, the expression significance and prognostic role of ENO1 in LUSC tissues were analyzed comprehensively. With the combination of all eligib...
Source: Journal of Oncology - September 10, 2021 Category: Cancer & Oncology Authors: Wan-Ying Huang Gang Chen Shang-Wei Chen Yi-Wu Dang Yun Deng Hua-Fu Zhou Jin-Liang Kong Yu Zhang Jun-Xian Mo Chang-Bo Li Juan He Source Type: research

Developing ZNF Gene Signatures Predicting Radiosensitivity of Patients with Breast Cancer
This study aimed to explore the relationship between the expression of zinc finger (ZNF) gene family proteins and the radiosensitivity of breast cancer patients. Clinical and gene expression data on a total of 976 breast cancer samples were obtained from The Cancer Genome Atlas (TCGA) database. ZNF gene expression was dichotomized into groups with a higher or lower level than the median level of expression. Univariate and multivariate Cox regression analyses were used to evaluate the relationship between ZNF gene expression levels and radiosensitivity. The Molecular Taxonomy Data of the International Federation of Breast C...
Source: Journal of Oncology - September 10, 2021 Category: Cancer & Oncology Authors: Derui Yan Mingjing Shen Zixuan Du Jianping Cao Ye Tian Ping Zeng Zaixiang Tang Source Type: research

The Indication of Poor Prognosis by High Expression of ENO1 in Squamous Cell Carcinoma of the Lung
J Oncol. 2021 Aug 30;2021:9910962. doi: 10.1155/2021/9910962. eCollection 2021.ABSTRACTThe purpose of this study is to investigate the significance of alpha-enolase (ENO1) expression in squamous cell carcinoma of the lung (LUSC), its prognostic value, and prospective molecular mechanism. Using multiplatforms data, including in-house immunohistochemistry, in-house real-time fluorescence quantitative polymerase chain reaction (RT-qPCR), in-house microarray, and public high-throughput data, the expression significance and prognostic role of ENO1 in LUSC tissues were analyzed comprehensively. With the combination of all eligib...
Source: Journal of Oncology - September 10, 2021 Category: Cancer & Oncology Authors: Wan-Ying Huang Gang Chen Shang-Wei Chen Yi-Wu Dang Yun Deng Hua-Fu Zhou Jin-Liang Kong Yu Zhang Jun-Xian Mo Chang-Bo Li Juan He Source Type: research

ABL1 Is a Prognostic Marker and Associated with Immune Infiltration in Hepatocellular Carcinoma
CONCLUSION: ABL1 is associated with immune infiltration and prognosis of HCC.PMID:34484330 | PMC:PMC8413061 | DOI:10.1155/2021/1379706 (Source: Journal of Oncology)
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Rongqiang Liu Weihao Kong ZeKun Jiang Shiyang Zheng Xiaofeng Yuan Linsen Ye Source Type: research

Prognostic Analysis of Lung Adenocarcinoma Based on DNA Methylation Regulatory Factor Clustering
J Oncol. 2021 Aug 26;2021:1557968. doi: 10.1155/2021/1557968. eCollection 2021.ABSTRACTThere is a known link between DNA methylation and cancer immunity/immunotherapy; however, the effect of DNA methylation on immunotherapy in lung adenocarcinoma (LUAD) remains to be elucidated. In the current study, we aimed to screen key markers for prognostic analysis of LUAD based on DNA methylation regulatory factor clustering. We classified LUAD using the NMF clustering method, and as a result, we obtained 20 DNA methylation regulatory genes. These 20 regulatory genes were used to determine the pattern of DNA methylation regulation, ...
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Yang Chen Caiming Zhong Shujun Bao Zheng Fang Hao Tang Source Type: research

Effect of Gambogic Acid on miR-199a-3p Expression and Cell Biological Behavior in Colorectal Cancer Cells
J Oncol. 2021 Aug 26;2021:5140621. doi: 10.1155/2021/5140621. eCollection 2021.ABSTRACTColorectal cancer (CC), as a malignancy threatening life and health, has a rising incidence in recent years. It has been reported that gambogic acid (GA) has antitumor activity in various tumors, but its effect on CC remains to be elucidated. In this investigation, the influence of GA nanoparticles on microRNA-199a-3p (miR-199a-3p) in CC was analyzed to provide a reliable reference for future clinical practice. Through PCR detection, we first determined that miR-199a-3p presented low expression in CC and had a significant effect in predi...
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Xiaodong Wang Yingchun Li Haihua Zhou Ning Han Linlin Pan Chen Yu Source Type: research

Landscape of Immune Microenvironment in Epithelial Ovarian Cancer and Establishing Risk Model by Machine Learning
CONCLUSION: High infiltration of immune cells predicted a better outcome and an antitumor phenotype in EOC, and the DCs might play a dominant role in the initiation of antitumor immune cells. The well-established risk model can be used for prognostic prediction in EOC.PMID:34484333 | PMC:PMC8416376 | DOI:10.1155/2021/5523749 (Source: Journal of Oncology)
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Shi-Yi Liu Rong-Hui Zhu Zi-Tao Wang Wei Tan Li Zhang Yan-Qing Wang Fang-Fang Dai Meng-Qin Yuan Ya-Jing Zheng Dong-Yong Yang Fei-Yan Wang Shu Xian Juan He Yu-Wei Zhang Ma-Li Wu Zhi-Min Deng Min Hu Yan-Xiang Cheng Ye-Qiang Liu Source Type: research

lncRNA MAGI2-AS3 Exerts Antioncogenic Roles in Hepatocellular Carcinoma via Regulating the miR-519c-3p/TXNIP Axis
CONCLUSION: MAGI2-AS3 inhibits HCC tumorigenesis through miR-519c-3p/TXNIP axis in vitro and in vivo, indicating MAGI2-AS3 plays a crucial role in HCC development.PMID:34484334 | PMC:PMC8416383 | DOI:10.1155/2021/5547345 (Source: Journal of Oncology)
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Huamei Wei Qianli Tang Anmin Wang Ya Zhang Zebang Qin Wenchuan Li Zuoming Xu Jianchu Wang Jian Pu Source Type: research

Robot-Assisted versus Laparoscopic Partial Nephrectomy for Giant Sporadic Renal Angiomyolipomas of ≥7 cm: A Propensity Score-Matched Analysis
J Oncol. 2021 Aug 26;2021:6395876. doi: 10.1155/2021/6395876. eCollection 2021.ABSTRACTBACKGROUND: To compare the perioperative and functional outcomes between robot-assisted partial nephrectomy (RAPN) and laparoscopic partial nephrectomy (LPN) for giant sporadic renal angiomyolipomas (AMLs) of ≥7 cm.MATERIALS AND METHODS: Patients with sporadic renal AMLs of ≥7 cm who underwent RAPN or LPN in the First Affiliated Hospital of Nanchang University between 2015 and 2020 were retrospectively analyzed. Propensity score matching (1 : 1) was performed to adjust for potential baseline confounders. Perioperative and functiona...
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Yunqiang Xiong Wen Deng Ru Chen Xiaoqiang Liu Ke Zhu Jiayao Wang Jiahui Long Haoxin Jiang Luyao Chen Bin Fu Source Type: research

Downregulation of PART1 Inhibits Proliferation and Differentiation of Hep3B Cells by Targeting hsa-miR-3529-3p/FOXC2 Axis
CONCLUSION: Results showed that downregulation of PART1 can partially inhibit proliferation and differentiation by targeting hsa-miR-3529-3p/FOXC2 axis.PMID:34484336 | PMC:PMC8410447 | DOI:10.1155/2021/7792223 (Source: Journal of Oncology)
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Zhicheng Weng Jianyang Peng Weida Wu Chunsheng Zhang Jianfeng Zhao Hongbin Gao Source Type: research

Plumbagin Enhances the Radiosensitivity of Tongue Squamous Cell Carcinoma Cells via Downregulating ATM
This study was designed to investigate whether plumbagin (PL) could sensitize ionizing radiation (IR) in tongue squamous cell carcinoma (TSCC) cells and its possible mechanisms. Cell proliferation and combination index analysis was based on MTT and colony formation assay. Flow cytometry was applied to analyze the cell cycle distribution and apoptosis after the treatment of PL and/or IR. RT-PCR was used to examine the gene expression level of ataxia telangiegatasiata muted (ATM) and nuclear factor kappa beta (NF-κB) after various treatment groups. Western blot was used to examine the protein level of ATM and NF-&kappa...
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Shu-Ting Pan Gan Huang Qiaohong Wang Jia-Xuan Qiu Source Type: research

Identification of a Nomogram from Ferroptosis-Related Long Noncoding RNAs Signature to Analyze Overall Survival in Patients with Bladder Cancer
This study aimed to establish a nomogram to predict the overall survival (OS) of patients with bladder cancer (BC) by ferroptosis-related long noncoding RNAs (FRlncRNAs) signature.METHODS: We obtained FRlncRNAs expression profiles and clinical data of patients with BC from the Cancer Genome Atlas database. The patients were divided into the training set, testing set, and overall set. Lasso regression and multivariate Cox regression were used to establish the FRlncRNAs signature, the prognosis of each group was compared by Kaplan-Meier (K-M) analysis, and the receiver operating characteristic (ROC) curve evaluated the accur...
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Yuanshan Cui Zhongbao Zhou Yumeng Chai Xuanyan Che Yong Zhang Source Type: research

Effect of Entecavir Combined with Adefovir Dipivoxil on Clinical Efficacy and TNF- < em > α < /em > and IL-6 Levels in Patients with Hepatitis B Cirrhosis
J Oncol. 2021 Aug 24;2021:9162346. doi: 10.1155/2021/9162346. eCollection 2021.ABSTRACTOBJECTIVE: The purpose of the study was to investigate the effect of entecavir combined with adefovir dipivoxil on clinical efficacy and TNF-α and IL-6 levels in patients with hepatitis B cirrhosis.METHODS: A total of 100 patients with hepatitis B cirrhosis admitted to our hospital between January 2018 and June 2019 were randomly selected and divided into the control group (n = 50) and experimental group (n = 50) according to the order of admission. Among them, the control group patients were treated with entecavir, while the patie...
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Yonghuan Yu Xinfeng Cui Jingjing Zhao Ting Jia Baofeng Ren Xiaoyan Zhang Source Type: research

Prostate-Specific Antigen Kinetics Effects on Outcomes of Low-Volume Metastatic Prostate Cancer Patients Receiving Androgen Deprivation Therapy
J Oncol. 2021 Aug 26;2021:9648579. doi: 10.1155/2021/9648579. eCollection 2021.ABSTRACTBACKGROUND: The present study aimed to analyse factors influencing the effects of androgen deprivation therapy (ADT) in patients with newly diagnosed metastatic castration-naïve prostate cancer (mCNPC), especially in low-volume disease (LVD), according to subclassification of metastatic prostate cancer established by the CHAARTED trial.MATERIALS AND METHODS: We reviewed 648 patients with newly diagnosed mCNPC receiving ADT at Chang Gung Memorial Hospital from January 2007 to December 2016. Basic characteristics and PSA kinetics prof...
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Yen-Chi Lin Po-Hung Lin I-Hung Shao Yuan-Cheng Chu Hung-Cheng Kan Chung-Yi Liu Kai-Jie Yu Ying-Hsu Chang See-Tong Pang Jhen-Ling Huang Cheng-Keng Chuang Source Type: research

ABL1 Is a Prognostic Marker and Associated with Immune Infiltration in Hepatocellular Carcinoma
CONCLUSION: ABL1 is associated with immune infiltration and prognosis of HCC.PMID:34484330 | PMC:PMC8413061 | DOI:10.1155/2021/1379706 (Source: Journal of Oncology)
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Rongqiang Liu Weihao Kong ZeKun Jiang Shiyang Zheng Xiaofeng Yuan Linsen Ye Source Type: research

Prognostic Analysis of Lung Adenocarcinoma Based on DNA Methylation Regulatory Factor Clustering
J Oncol. 2021 Aug 26;2021:1557968. doi: 10.1155/2021/1557968. eCollection 2021.ABSTRACTThere is a known link between DNA methylation and cancer immunity/immunotherapy; however, the effect of DNA methylation on immunotherapy in lung adenocarcinoma (LUAD) remains to be elucidated. In the current study, we aimed to screen key markers for prognostic analysis of LUAD based on DNA methylation regulatory factor clustering. We classified LUAD using the NMF clustering method, and as a result, we obtained 20 DNA methylation regulatory genes. These 20 regulatory genes were used to determine the pattern of DNA methylation regulation, ...
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Yang Chen Caiming Zhong Shujun Bao Zheng Fang Hao Tang Source Type: research

Effect of Gambogic Acid on miR-199a-3p Expression and Cell Biological Behavior in Colorectal Cancer Cells
J Oncol. 2021 Aug 26;2021:5140621. doi: 10.1155/2021/5140621. eCollection 2021.ABSTRACTColorectal cancer (CC), as a malignancy threatening life and health, has a rising incidence in recent years. It has been reported that gambogic acid (GA) has antitumor activity in various tumors, but its effect on CC remains to be elucidated. In this investigation, the influence of GA nanoparticles on microRNA-199a-3p (miR-199a-3p) in CC was analyzed to provide a reliable reference for future clinical practice. Through PCR detection, we first determined that miR-199a-3p presented low expression in CC and had a significant effect in predi...
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Xiaodong Wang Yingchun Li Haihua Zhou Ning Han Linlin Pan Chen Yu Source Type: research

Landscape of Immune Microenvironment in Epithelial Ovarian Cancer and Establishing Risk Model by Machine Learning
CONCLUSION: High infiltration of immune cells predicted a better outcome and an antitumor phenotype in EOC, and the DCs might play a dominant role in the initiation of antitumor immune cells. The well-established risk model can be used for prognostic prediction in EOC.PMID:34484333 | PMC:PMC8416376 | DOI:10.1155/2021/5523749 (Source: Journal of Oncology)
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Shi-Yi Liu Rong-Hui Zhu Zi-Tao Wang Wei Tan Li Zhang Yan-Qing Wang Fang-Fang Dai Meng-Qin Yuan Ya-Jing Zheng Dong-Yong Yang Fei-Yan Wang Shu Xian Juan He Yu-Wei Zhang Ma-Li Wu Zhi-Min Deng Min Hu Yan-Xiang Cheng Ye-Qiang Liu Source Type: research

lncRNA MAGI2-AS3 Exerts Antioncogenic Roles in Hepatocellular Carcinoma via Regulating the miR-519c-3p/TXNIP Axis
CONCLUSION: MAGI2-AS3 inhibits HCC tumorigenesis through miR-519c-3p/TXNIP axis in vitro and in vivo, indicating MAGI2-AS3 plays a crucial role in HCC development.PMID:34484334 | PMC:PMC8416383 | DOI:10.1155/2021/5547345 (Source: Journal of Oncology)
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Huamei Wei Qianli Tang Anmin Wang Ya Zhang Zebang Qin Wenchuan Li Zuoming Xu Jianchu Wang Jian Pu Source Type: research

Robot-Assisted versus Laparoscopic Partial Nephrectomy for Giant Sporadic Renal Angiomyolipomas of ≥7 cm: A Propensity Score-Matched Analysis
J Oncol. 2021 Aug 26;2021:6395876. doi: 10.1155/2021/6395876. eCollection 2021.ABSTRACTBACKGROUND: To compare the perioperative and functional outcomes between robot-assisted partial nephrectomy (RAPN) and laparoscopic partial nephrectomy (LPN) for giant sporadic renal angiomyolipomas (AMLs) of ≥7 cm.MATERIALS AND METHODS: Patients with sporadic renal AMLs of ≥7 cm who underwent RAPN or LPN in the First Affiliated Hospital of Nanchang University between 2015 and 2020 were retrospectively analyzed. Propensity score matching (1 : 1) was performed to adjust for potential baseline confounders. Perioperative and functiona...
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Yunqiang Xiong Wen Deng Ru Chen Xiaoqiang Liu Ke Zhu Jiayao Wang Jiahui Long Haoxin Jiang Luyao Chen Bin Fu Source Type: research

Downregulation of PART1 Inhibits Proliferation and Differentiation of Hep3B Cells by Targeting hsa-miR-3529-3p/FOXC2 Axis
CONCLUSION: Results showed that downregulation of PART1 can partially inhibit proliferation and differentiation by targeting hsa-miR-3529-3p/FOXC2 axis.PMID:34484336 | PMC:PMC8410447 | DOI:10.1155/2021/7792223 (Source: Journal of Oncology)
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Zhicheng Weng Jianyang Peng Weida Wu Chunsheng Zhang Jianfeng Zhao Hongbin Gao Source Type: research

Plumbagin Enhances the Radiosensitivity of Tongue Squamous Cell Carcinoma Cells via Downregulating ATM
This study was designed to investigate whether plumbagin (PL) could sensitize ionizing radiation (IR) in tongue squamous cell carcinoma (TSCC) cells and its possible mechanisms. Cell proliferation and combination index analysis was based on MTT and colony formation assay. Flow cytometry was applied to analyze the cell cycle distribution and apoptosis after the treatment of PL and/or IR. RT-PCR was used to examine the gene expression level of ataxia telangiegatasiata muted (ATM) and nuclear factor kappa beta (NF-κB) after various treatment groups. Western blot was used to examine the protein level of ATM and NF-&kappa...
Source: Journal of Oncology - September 6, 2021 Category: Cancer & Oncology Authors: Shu-Ting Pan Gan Huang Qiaohong Wang Jia-Xuan Qiu Source Type: research