Role of Dynamic Susceptibility Contrast Perfusion MRI in Glioma Progression Evaluation
This study aims to explore if dynamic susceptibility contrast- (DSC-) MRI can improve the evaluation of glioma progression. We enrolled 65 glioma patients with suspected gadolinium-enhancing lesion. Longitudinal MRI follow-up (mean 590 days, range: 210-2670 days) or re-operation (n = 3) was used to confirm true progression (n = 51) and pseudoprogression (n = 14). We assessed the diagnostic performance of each MRI variable and the different combinations. Our results showed that the relative cerebral blood volume (rCBV) in the true progression group (1.094, 95%CI: 1.135-1.636) was significantly higher than that of the pseudo...
Source: Journal of Oncology - February 25, 2021 Category: Cancer & Oncology Authors: Guanmin Quan Kexin Zhang Yawu Liu Jia-Liang Ren Deyou Huang Weiwei Wang Tao Yuan Source Type: research

Corrigendum to "Performance of Distress Thermometer and Associated Factors of Psychological Distress among Chinese Cancer Patients"
J Oncol. 2021 Feb 9;2021:5318381. doi: 10.1155/2021/5318381. eCollection 2021.ABSTRACT[This corrects the article DOI: 10.1155/2020/3293589.].PMID:33628240 | PMC:PMC7886571 | DOI:10.1155/2021/5318381 (Source: Journal of Oncology)
Source: Journal of Oncology - February 25, 2021 Category: Cancer & Oncology Authors: Sudip Thapa Huihui Sun Ahmad Khalid Aalemi Gaurab Pokhrel Bangyan Wang Sanuja Dahal Shiying Yu Source Type: research

Impact of Pathologic Complete Response following Neoadjuvant Chemotherapy  ± Trastuzumab in Locally Advanced Breast Cancer
CONCLUSION: Women with ER+/HER2- disease are the least likely to achieve pCR, with the highest rates in HER2+ and triple-negative subgroups. Degree of response is associated with OS; despite the comparatively higher likelihood of achieving pCR in ER-/HER2+ and triple-negative, these subgroups experience a survival detriment. We are consistent with the published data that patients who attain the pathological complete response defined as ypT0/ypN0 have improved outcomes.PMID:33628241 | PMC:PMC7895557 | DOI:10.1155/2021/6639763 (Source: Journal of Oncology)
Source: Journal of Oncology - February 25, 2021 Category: Cancer & Oncology Authors: Taher Al-Tweigeri Mahmoud Elshenawy Ahmed Badran Ayman Omar Kausar Suleman Osama Al Malik Ihab Anwar Noha Jastaniya Asma Tulbah Mohammad Al Shabanah Dahish Ajarim Adher Al Sayed Source Type: research

The Role of Dyslipidemia in Colitis-Associated Colorectal Cancer
J Oncol. 2021 Feb 12;2021:6640384. doi: 10.1155/2021/6640384. eCollection 2021.ABSTRACTDyslipidemia, characterized by metabolic abnormalities, has become an important participant in colorectal cancer (CRC). Dyslipidemia aggravates intestinal inflammation, destroys the protective mucous layer, and disrupts the balance between injury and recovery. On the other hand, antioxidants induced by oxidative stress enhance glycolysis to maintain the acquisition of ATP allowing epithelial cells with damaged genomes to survive. In the repetitive phase of colitis, survival factors enable these epithelial cells to continuously proliferat...
Source: Journal of Oncology - February 25, 2021 Category: Cancer & Oncology Authors: Ke Chen Jianrong Guo Tao Zhang Jian Gu Huili Li Jiliang Wang Source Type: research

Identifying Stage II Colorectal Cancer Recurrence Associated Genes by Microarray Meta-Analysis and Building Predictive Models with Machine Learning Algorithms
CONCLUSIONS: We identified 479 stage II colorectal cancer recurrence associated genes by microarray meta-analysis. The random survival forest model which was based on the recurrence associated gene signature could strongly predict the recurrence risk of stage II colorectal cancer patients.PMID:33628243 | PMC:PMC7889382 | DOI:10.1155/2021/6657397 (Source: Journal of Oncology)
Source: Journal of Oncology - February 25, 2021 Category: Cancer & Oncology Authors: Wei Lu Xiang Pan Siqi Dai Dongliang Fu Maxwell Hwang Yingshuang Zhu Lina Zhang Jingsun Wei Xiangxing Kong Jun Li Qian Xiao Kefeng Ding Source Type: research

Survival Analysis of Radiation Therapy in Ovarian Cancer: A SEER Database Analysis
J Oncol. 2021 Feb 11;2021:8849039. doi: 10.1155/2021/8849039. eCollection 2021.ABSTRACTRESULTS: A total of 20031 ovarian cancer patients were included, with 291 (1.45%) patients who received radiotherapy. The median overall survival (OS) in patients who received radiotherapy was shorter than which in patients without radiotherapy (23 vs. 75 months, P
Source: Journal of Oncology - February 25, 2021 Category: Cancer & Oncology Authors: Lushi Yu Hongyun Gong Qian Li Honggang Ren Yi Wang Haihua He Tian Li Qibin Song Source Type: research

Long Noncoding RNA LINC00526 Represses Glioma Progression via Regulating miR-5581-3p/BEX1
J Oncol. 2021 Feb 4;2021:8171250. doi: 10.1155/2021/8171250. eCollection 2021.ABSTRACTThe roles of long noncoding RNAs (lncRNAs) in regulating glioma progression have been widely recognized in recent years. This work was to investigate the roles and associated mechanisms of LINC00526 in glioma progression. LINC00526 expression in glioma tissues and cells and their normal counterparts was measured with quantitative real-time polymerase chain reaction method. Functions of LINC00526 in glioma were investigated with in vitro experiments. Moreover, competitive RNA (ceRNA) theory was employed to understand mechanisms of action o...
Source: Journal of Oncology - February 22, 2021 Category: Cancer & Oncology Authors: Jian Yan Youping Li Chunhua Xu Bin Tang Shenhao Xie Tao Hong Erming Zeng Source Type: research

Identification of a Novel Metastasis-Related miRNAs-Based Signature for Predicting the Prognosis of Hepatocellular Carcinoma.
Authors: Chen Y, Wang G, Xu H, Wang H, Bai D Abstract Hepatocellular carcinoma (HCC) is one of the most common internal malignancies worldwide and is associated with a poor prognosis. Abnormal expression of miRNAs is believed to play a role in the recurrent metastasis of HCC. However, limited studies on the role of miRNAs in HCC metastasis have been carried out. Therefore, this study is aimed at exploring the potential value of metastasis-related miRNAs (MRMs) in HCC. We retrieved MRMs were from the Human Cancer Metastasis Database. Differential miRNAs were identified for tumor samples of HCC patients and normal sa...
Source: Journal of Oncology - February 21, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Clinical Characteristics and Prognostic Analysis of Multiple Myeloma with Extramedullary Disease: A SEER-Based Study.
Conclusion: Age at MM diagnosis, site of EMD, and time interval from diagnosis to EMD occurrence were independent prognostic factors in MM patients with EMD. EMD-B bore a better prognosis than EMD-S. PMID: 33603785 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - February 21, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Serum Cytokine Profiles of Melanoma Patients and Their Association with Tumor Progression and Metastasis.
Conclusions: We found that the levels of VEGF-A and PDGF-BB in the serum of both primary and metastatic melanoma patients are elevated. TNF-α, IFN-γ, and VEGF-A presented a positive correlation with Breslow thickness, whereas BDNF showed a negative association. MIP-1α and MCP-1 correlated negatively with survival. In addition, lower levels of IL-7 were found in patients harboring BRAF mutants. These findings indicate that these cytokines may play critical roles in the progression of melanoma. PMID: 33574842 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - February 13, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Characterization of Artificial Pneumothorax-Unrelated Pyothorax-Associated Lymphoma.
In conclusion, the features of artificial pneumothorax-unrelated PAL are comparable with the classic type of PAL, except for some patients with short duration of pleuritis, and need to be identified. Treatment guideline of DLBCL is recommended for the management of PAL. PMID: 33564306 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - February 12, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Exosomal MiR-1290 Promotes Angiogenesis of Hepatocellular Carcinoma via Targeting SMEK1.
In this study, our miRNome sequencing demonstrated that miR-1290 was overexpressed in HCC patient serum-derived exosomes, and we found that delivery of miR-1290 into human endothelial cells enhanced their angiogenic ability. Our results further revealed that SMEK1 is a direct target of miR-1290 in endothelial cells. MiR-1290 exerted its proangiogenic function, at least in part, by alleviating the inhibition of VEGFR2 phosphorylation done by SMEK1. Collectively, our findings provide evidence that miR-1290 is overexpressed in HCC and promotes tumor angiogenesis via exosomal secretion, implicating its potential role as a ther...
Source: Journal of Oncology - February 12, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Impact of Postmastectomy Radiotherapy on Locoregional Control and Disease-Free Survival in Patients with Breast Cancer Treated with Neoadjuvant Chemotherapy.
Conclusion: Results showed that PMRT significantly reduced the LRR of patients with clinical stage II-III breast cancer after receiving NAC and mastectomy. YpN0 patients derived no local control or survival benefit after receiving PMRT, whereas those with ypN1 and ypN2-3 could obviously benefit from PMRT. PMID: 33564308 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - February 12, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Identification and Analysis of Three Hub Prognostic Genes Related to Osteosarcoma Metastasis.
Authors: Tan J, Liang H, Yang B, Zhu S, Wu G, Li L, Liu Z, Li L, Qi W, Li S, Lin L Abstract Osteosarcoma (OS) often occurs in children and often undergoes metastasis, resulting in lower survival rates. Information on the complexity and pathogenic mechanism of OS is limited, and thus, the development of treatments involving alternative molecular and genetic targets is hampered. We categorized transcriptome data into metastasis and nonmetastasis groups, and 400 differential RNAs (230 messenger RNAs (mRNAs) and 170 long noncoding RNAs (lncRNAs)) were obtained by the edgeR package. Prognostic genes were identified by p...
Source: Journal of Oncology - February 12, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

ACE2 Is a Prognostic Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma: Implication for COVID-19.
Conclusion: ACE2 was downregulated in KIRC and served as a prognostic biomarker. It was also shown to be associated with immune infiltration. PMID: 33564310 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - February 12, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

DOK7 Inhibits Cell Proliferation, Migration, and Invasion of Breast Cancer via the PI3K/PTEN/AKT Pathway.
In this study, we clarified the effects of DOK7 in breast cancer. First, we showed that DOK7 expression was obviously reduced in the breast cancer tissues and lower levels of DOK7 linked to more aggressive behaviors and worse prognosis of patients. Furthermore, DOK7 expression of various breast cancer cell lines was lower than that of human noncancerous MCF-10A cells. Overexpression of DOK7 inhibited proliferation, migration, and invasion, while silencing DOK7 expression promoted the malignancy of breast cancer. In addition, overexpression of DOK7 suppressed tumor proliferation and lung metastasis in animal models. Finally...
Source: Journal of Oncology - February 9, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Hypoxia Molecular Characterization in Hepatocellular Carcinoma Identifies One Risk Signature and Two Nomograms for Clinical Management.
Authors: Liu Z, Liu L, Lu T, Wang L, Li Z, Jiao D, Han X Abstract Hypoxia is a universal feature in the tumor microenvironment (TME). Nonetheless, the heterogeneous hypoxia patterns of TME have still not been elucidated in hepatocellular carcinoma (HCC). Using consensus clustering algorithm and public datasets, we identified heterogeneous hypoxia subtypes. We also revealed the specific biological and clinical characteristics via bioinformatic methods. The principal component analysis algorithm was employed to develop a hypoxia-associated risk score (HARS). We identified the two hypoxia subtypes: low hypoxia pattern...
Source: Journal of Oncology - February 9, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Prechemoradiotherapy Systemic Inflammation Response Index Stratifies Stage IIIB/C Non-Small-Cell Lung Cancer Patients into Three Prognostic Groups: A Propensity Score-Matching Analysis.
Authors: Topkan E, Selek U, Kucuk A, Haksoyler V, Ozdemir Y, Sezen D, Mertsoylu H, Besen AA, Bolukbasi Y, Ozyilkan O, Pehlivan B Abstract Purpose: We explored the prognostic influence of the systemic inflammation response index (SIRI) on the survival outcomes of stage IIIB/C non-small-cell lung cancer (NSCLC) patients who underwent concurrent chemoradiotherapy. Methods: Present propensity score-matching (PSM) analysis comprised 876 stage IIIB/C NSCLC patients who received 1-3 cycles of platinum-based doublets concurrent with thoracic radiotherapy from 2007 to 2017. The primary and secondary objectives were the ...
Source: Journal of Oncology - February 9, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

High Expression of Interleukin-2 Receptor Subunit Gamma Reveals Poor Prognosis in Human Gastric Cancer.
This study aimed to reveal that interleukin-2 receptor subunit gamma (IL2RG) is such a key molecule in human GC progression. GC tissues and paracancerous gastric tissues were collected from 7 patients (5 males and 2 females) during tumor radical excision surgery. These tissues were used to identify the differentially expressed genes (DEGs) with RNA-seq and serial bioinformatics analyses including Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, gene expression profiling interactive analysis (GEPIA), and survival analysis. RT-qPCR and western blotting were performed to compare the mRNA and protein expression...
Source: Journal of Oncology - February 6, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Neutrophil-Lymphocyte Ratio as a Prognostic Parameter in NSCLC Patients Receiving EGFR-TKIs: A Systematic Review and Meta-Analysis.
Conclusion: In conclusion, our meta-analysis revealed that lower NLR predicted a better survival (PFS and OS) in patients receiving the treatment of EGFR-TKIs. PMID: 33542732 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - February 6, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

miR-301b-3p Regulates Breast Cancer Cell Proliferation, Migration, and Invasion by Targeting NR3C2.
Conclusion: The present study revealed for the first time that miR-301b-3p could foster breast cancer cell proliferation, migration, and invasion by targeting NR3C2, unveiling that miR-301b-3p is a novel carcinogen in breast cancer. PMID: 33542733 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - February 6, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Antitumor Effects of Paeoniflorin on Hippo Signaling Pathway in Gastric Cancer Cells.
Conclusion: Hence, targeting TAZ with paeoniflorin could be a novel approach for the treatment of human gastric cancer. PMID: 33531900 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - February 5, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Knockdown of RhoC Inhibits Oral Squamous Cell Carcinoma Cell Invasion and Metastasis via Regulation of HMGA2.
Authors: Gao F, Yin P, Wu Y, Wen J, Su Y, Zhang X Abstract Ras homolog family member C (RhoC) is an important component of intracellular signal transduction and its overexpression has been reported to be involved in regulating tumor proliferation, invasion, and metastasis in various malignant tumors. However, its role and underlying mechanism in oral squamous cell carcinoma (OSCC) still remain obscure. In our study, RhoC expression, its relation with clinical stages, and survival rate in OSCC were analyzed using datasets from The Cancer Genome Atlas (TCGA). Next, a RhoC knockdown cell model was established in vitro...
Source: Journal of Oncology - February 2, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Ferroptosis-Related Gene Model to Predict Overall Survival of Ovarian Carcinoma.
Conclusion: The ferroptosis-related gene signature could predict the OS of OC patients and improve therapeutic decision-making. PMID: 33519933 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - February 2, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Long-Term Survival of Patients with Metastatic Non-Small-Cell Lung Cancer over Five Decades.
Authors: Bar J, Urban D, Amit U, Appel S, Onn A, Margalit O, Beller T, Kuznetsov T, Lawrence Y Abstract Objective: Novel therapeutics and supportive care improved outcomes for metastatic non-small-cell lung cancer (mNSCLC) patients. Major advances over the past five decades include the introduction of combination chemotherapy, small molecules targeting mutant proteins, especially EGFR, and more recently immunotherapy. We aim to document real-world long-term survival over the past five decades. Methods: Survival statistics were extracted from the Survival, Epidemiology, and End Results (SEER) database for mNSCLC...
Source: Journal of Oncology - February 2, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Evaluation of Hippo Pathway and CD133 in Radiation Resistance in Small-Cell Lung Cancer.
Authors: Yang K, Zhao Y, Du Y, Tang R Abstract Although the Hippo pathway and CD133 have been reported to play pertinent roles in a variety of cancer, knowledge about their contribution to radiation resistance in small-cell lung cancer (SCLC) is limited. In this first-of-a-kind study, we have reported the expression of key Hippo pathway proteins in SCLC patients by immunohistochemical staining. We assessed the involvement of yes-associated protein 1 (YAP1) in radiation resistance by Cell Counting Kit-8 (CCK-8) and flow cytometry. In addition, we analysed the impact of CD133 on radiotherapy for SCLC. The mammalian S...
Source: Journal of Oncology - February 2, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Dynamic Changes of Urine Proteome in Rat Models Inoculated with Two Different Hepatoma Cell Lines.
Authors: Zhang Y, Gao Y, Wei J, Gao Y Abstract Urine can accumulate systemic changes with no mechanism to be stable, which may reflect early changes associated with physiological or pathophysiological processes. To explore the potential value of the urine proteome, two rat models were established by intrahepatic injection of two different hepatoma cell lines, CBRH-7919 and RH-35. Urine samples were collected and analyzed. Compared with controls, the two models exhibited different numbers and types of differentially expressed urinary proteins despite having similar histological results. The results were compared wit...
Source: Journal of Oncology - January 30, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Body Composition Analysis of 10 Years versus 5 Years of Adjuvant Endocrine Therapy in Patients with Nonmetastatic Breast Cancer.
Conclusion: In conclusion, breast cancer patients with 10 years of adjuvant endocrine therapy had DFS benefit, but with more muscle loss and adipose tissue deposits compared to patients receiving 5 years of adjuvant endocrine therapy. PMID: 33510788 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - January 30, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

MicroRNA-Based Cancer Mortality Risk Scoring System and hTERT Expression in Early-Stage Oral Squamous Cell Carcinoma.
Authors: Yoon AJ, Santella RM, Wang S, Kutler DI, Carvajal RD, Philipone E, Wang T, Peters SM, Stewart CR, Momen-Heravi F, Troob S, Levin M, AkhavanAghdam Z, Shackelford AJ, Canterbury CR, Shimonosono M, Hernandez BY, McDowell BD, Nakagawa H Abstract We have previously constructed a novel microRNA (miRNA)-based prognostic model and cancer-specific mortality risk score formula to predict survival outcome in oral squamous cell carcinoma (OSCC) patients who are already categorized into "early-stage" by the TNM staging system. A total of 836 early-stage OSCC patients were assigned the mortality risk scores. W...
Source: Journal of Oncology - January 30, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Genomic Mutations of Primary and Metastatic Lung Adenocarcinoma in Chinese Patients.
This study aims to reveal the landscapes of genomic mutations in primary and metastatic LUAD and their actionability. This study enrolled 636 patients with LUAD, of whom 85 and 551 were from patients with and without metastasis, respectively. Next-generation sequencing technology was used to retrieve their genomic information. Genomic mutations including short nucleotide variation, long variation, copy number variations, and fusions were called. The corresponding actionability was revealed. A comparison of genomic mutations and actionability between primary and metastatic LUAD was performed. In primary tumors, BRCA2 and FA...
Source: Journal of Oncology - January 27, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Survivin Regulates Bad Gene Expression by Binding to Its Promoter and Modulates Cell Cycle and Apoptosis in Esophageal Carcinoma Cell.
Authors: Chen Y, Bieerkehazhi S, Li X, Ma L, Yibulayin W, Ran J Abstract Esophageal cancer (EC) is the eighth most prevalent cancer and the sixth leading cause of cancer-related mortality worldwide. As an antiapoptotic and a proapoptotic protein, respectively, survivin and Bad play an important role in carcinogenesis of the most human cancers including EC. However, the regulatory relationships between them remain unclear. We sought to investigate the effects of survivin knockdown and overexpression on the expression of Bad gene, cell cycle progression, and apoptosis of esophageal carcinoma cell. The mRNA expression...
Source: Journal of Oncology - January 27, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Combination of Immune Checkpoint Inhibitors and Radiotherapy for Advanced Non-Small-Cell Lung Cancer and Prostate Cancer: A Meta-Analysis.
Authors: Xu Z, Feng J, Weng Y, Jin Y, Peng M Abstract Objectives: Immune checkpoint inhibitors (ICI) combined with radiotherapy (RT) have emerged as a breakthrough therapy in the treatment of various cancers. The combination has a strong rationale, but data on their efficacy and safety are still limited. Hence, we comprehensively searched the database and performed this study to elucidate the clinical manifestations of this combined strategy. Methods: We performed a meta-analysis of randomized trials that compared ICI plus RT with placebo plus RT or ICI alone for the treatment of advanced nonsmall-cell lung can...
Source: Journal of Oncology - January 27, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

LMTK2 as Potential Biomarker for Stratification between Clinically Insignificant and Clinically Significant Prostate Cancer.
Authors: Vezelis A, Simiene J, Dabkeviciene D, Kincius M, Ulys A, Suziedelis K, Jarmalaite S, Jankevicius F Abstract A set of prostate tumors tend to grow slowly and do not require active treatment. Therefore, stratification between patients with clinically significant and clinically insignificant prostate cancer (PC) remains a vital issue to avoid overtreatment. Fast development of genetic technologies accelerated development of next-generation molecular tools for reliable PC diagnosis. The aim of this study is to evaluate the diagnostic value of molecular biomarkers (CRISP3, LMTK2, and MSMB) for separation of PC ...
Source: Journal of Oncology - January 27, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Clinicopathological Characteristics of Breast Ductal Carcinoma In Situ: An Analysis of Chinese Population of 617 Patients.
Conclusions: The clinicopathological characteristics of Chinese DCIS patients include less detection on screening, younger age at diagnosis, and more low-intermediate nuclear grade. PMID: 33488713 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - January 27, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Identification of a Prognostic Risk Signature of Kidney Renal Clear Cell Carcinoma Based on Regulating the Immune Response Pathway Exploration.
Authors: Wu G, Xu Y, Han C, Wang Z, Li J, Wang Q, Che X Abstract Purpose: To construct a survival model for predicting the prognosis of patients with kidney renal clear cell carcinoma (KIRC) based on gene expression related to immune response regulation. Materials and Methods: KIRC mRNA sequencing data and patient clinical data were downloaded from the TCGA database. The pathways and genes involved in the regulation of the immune response were identified from the GSEA database. A single factor Cox analysis was used to determine the association of mRNA in relation to patient prognosis (P
Source: Journal of Oncology - January 20, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Identification of Risk Factors Associated with Axillary Lymph Node Metastasis for Sentinel Lymph Node-Positive Breast Cancer Patients.
This study aimed to identify clinicopathological factors related to the extent of axillary lymph node (ALN) involvement in early-stage BC patients with positive sentinel lymph nodes (SLNs). Methods: This was a retrospective analysis of 566 patients in cT1-2N0M0 with 1-2 positive SLNs that underwent axillary lymph node dissection (ALND) at Sun Yat-Sen Memorial Hospital. The clinical and pathologic data from these patients were analyzed. Results: Of these 566 patients, 235 (41.5%) exhibited NSLN metastases. Multivariate analysis revealed that the number of positive SLNs (odds ratio (OR) = 1.511; P=0.038...
Source: Journal of Oncology - January 20, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

FGFR4 c.1162G   >  A (p.Gly388Arg) Polymorphism Analysis in Turkish Patients with Retinoblastoma.
Conclusions: In patients with advanced retinoblastoma who were diagnosed with retinoblastoma prior to 24 months, the FGFR4 p.Gly388Arg allele was found to be significantly higher. As a result, these results indicate that the polymorphism of FGFR4 p.Gly388Arg may play a role in both the development of tumors and the progression of aggressive tumors. PMID: 33456465 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - January 20, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Genomic Profiling and Functional Analysis of let-7c miRNA-mRNA Interactions Identify SOX13 to Be Involved in Invasion and Progression of Pancreatic Cancer.
Authors: Nelson SR, Roche S, Cotter M, Garcia PA, Reitmeier D, Zollbrecht E, O'Neill F, Clynes M, Doolan P, Medha JP, Swan N, Larkin A, Walsh N Abstract Background: Pancreatic cancer is a devastating disease; its lethality is related to rapid growth and tendency to invade adjacent organs and metastasize at an early stage. Objective: The aim of this study was to identify miRNAs and their gene targets involved in the invasive phenotype in pancreatic cancer to better understand the biological behaviour and the rapid progression of this disease. Methods: miRNA profiling was performed in isogenic matched high in...
Source: Journal of Oncology - January 13, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Recurrent Pleomorphic Adenoma of the Parotid Gland: Experience of 128 Patients with First Recurrence.
Authors: Dai L, Lou W, Fang Q, Zhang X Abstract Objective: Recurrence is common after inappropriate surgical procedures for parotid pleomorphic adenoma (PA). However, there are some controversies regarding intraoperative tumor rupture and disease recurrence; therefore, our goal was to clarify this relationship by describing our experience with 128 cases of recurrent parotid PA. Methods: Patients suffering from a first recurrence of parotid PA were prospectively enrolled, and data regarding the operation, pathology, immunohistochemistry, and recurrence pattern (outside the previous surgical field vs. inside the ...
Source: Journal of Oncology - January 13, 2021 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Real-World Safety and Efficacy of Nivolumab in Advanced Squamous and Nonsquamous Non-Small-Cell Lung Cancer: A Retrospective Cohort Study in Croatia, Hungary, and Malta.
Conclusions: The safety and efficacy of nivolumab in previously treated patients with advanced NSCLC in the real-world South East Europe clinical settings were consistent with the results of randomized clinical trials and comparable to the results from other countries. PMID: 33376489 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - December 31, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

The Dependence between Urinary Levels of Angiogenesis Factors, 8-Iso-prostaglandin F2 α, ɣ-Synuclein, and Interleukin-13 in Patients with Bladder Cancer: A Pilot Study.
The Dependence between Urinary Levels of Angiogenesis Factors, 8-Iso-prostaglandin F2α, ɣ-Synuclein, and Interleukin-13 in Patients with Bladder Cancer: A Pilot Study. J Oncol. 2020;2020:4848752 Authors: Szymańska B, Sawicka E, Matuszewski M, Dembowski J, Piwowar A Abstract During the last decade, a significant increase in the incidence of bladder cancer (BC) has been observed. Angiogenesis plays a key role in the process of tumor growth and metastasis. Additionally, the participation of oxidative stress and chronic inflammation in BC pathogenesis is indicated. The aim of the study was to evalu...
Source: Journal of Oncology - December 23, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Tumor-Derived Exosomal miR-620 as a Diagnostic Biomarker in Non-Small-Cell Lung Cancer.
This study aimed to determine whether the serum exosomal biomarkers can improve the diagnosis of patients with non-small-cell lung cancer (NSCLC). Materials and Methods: The exosomes were extracted from the serum of NSCLC patients (n = 235) and healthy donors (n = 231) using ultracentrifugation and then were evaluated by using transmission electron microscopy, qNano, and western blotting. The serum exosomal miRNA expression was validated using qPCR. Results: Exosomal miR-620 was significantly reduced in NSCLC and early-stage NSCLC patients (P
Source: Journal of Oncology - December 23, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Corrigendum to "Seroprevalence of Human Betaretrovirus Surface Protein Antibodies in Patients with Breast Cancer and Liver Disease".
Corrigendum to "Seroprevalence of Human Betaretrovirus Surface Protein Antibodies in Patients with Breast Cancer and Liver Disease". J Oncol. 2020;2020:7406146 Authors: Zhang G, Bashiri K, Kneteman M, Cave K, Hong Y, Mackey JR, Alter HJ, Mason AL Abstract [This corrects the article DOI: 10.1155/2020/8958192.]. PMID: 33343664 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - December 23, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Construction of Nomograms for Predicting Lung and Bone Metastases in Patients with Intrahepatic Cholangiocarcinoma and Identification of Patients Who Can Benefit from Chemotherapy.
Conclusions: The nomograms could assess the possibility of LM and BM in ICC patients and determine the optimal treatment. PMID: 33343665 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - December 23, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

The Predictive Value of 2D Myocardial Strain for Epirubicin-Induced Cardiotoxicity.
Authors: Ben Abdallah I, Ben Nasr S, Chourabi C, Boukhris M, Ben Abdallah I, Zribi A, Fendri S, Balti M, Fehri W, Chraiet N, Haddaoui A Abstract Introduction: Although epirubicin has significantly improved outcome in breast cancer (BC) patients, it is responsible for myocardial dysfunction that affects patients' quality of life. The use of 2D global longitudinal strain (GLS) has been reported to detect early myocardial dysfunction. The aim of this study was to evaluate how GLS changes can predict cardiotoxicity. Methods: We conducted a prospective study from March 2018 to March 2020 on 66 patients with no cardi...
Source: Journal of Oncology - December 20, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Expression and Prognostic Analysis of Integrins in Gastric Cancer.
Authors: Wang JF, Wang Y, Zhang SW, Chen YY, Qiu Y, Duan SY, Li BP, Chen JQ Abstract Background: Integrins are involved in the biological process of a variety of cancers, but their importance in the diagnosis and prognosis of gastric cancer (GC) is still unclear. Therefore, this study aimed at exploring the significance of ITG gene expression in GC to evaluate its diagnosis and prognosis. Methods: GEPIA data were used to evaluate the mRNA expression of ITG genes in GC patients. The prognostic value of these genes was assessed by analyzing their mRNA expression using the Kaplan-Meier curve. The biological functi...
Source: Journal of Oncology - December 20, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Cell-Permeable Bak BH3 Peptide Induces Chemosensitization of Hematologic Malignant Cells.
In this study, we report the ability of the cell-permeable Bak BH3 peptide to restore apoptosis and induce chemosensitization of acute lymphoblastic leukemia and non-Hodgkin's lymphoma cell lines, and this event is enhanced with the coadministration of cell-permeable Bax BH3 peptide and represents an attractive approach to improve the patient outcomes with relapsed or refractory hematological malignant cells. PMID: 33312200 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - December 15, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Moderately Hypofractionated Radiotherapy with Simultaneous Integrated Boost in Prostate Cancer: A Comparative Study with Conventionally Fractionated Radiation.
Conclusions: Results obtained in this study showed that moderately hypofractionated RT employing SIB can be an effective approach providing valuable clinical outcomes with an acceptable toxicity profile. PMID: 33312201 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - December 15, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research