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Total 964 results found since Jan 2013.
Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions
J Toxicol Sci. 2021;46(6):283-288. doi: 10.2131/jts.46.283.ABSTRACTAbasic sites are formed in cells by various factors including environmental mutagens and considered to be involved in cancer initiation, promotion, and progression. A chemically stable abasic site analog (tetrahydrofuran-type analog, THF) induces untargeted base substitutions as well as targeted substitution and large deletion mutations in human cells. The untargeted substitutions may be initiated by the cleavage of the DNA strand bearing THF by the human apurinic/apyrimidinic endonuclease 1 (APE1) protein, the major repair enzyme for THF and abasic sites. ...
Source: Journal of Toxicological Sciences - June 3, 2021 Category: Toxicology Authors: Tetsuya Suzuki Yuri Katayama Yasuo Komatsu Hiroyuki Kamiya Source Type: research
Exploration of novel candidate genes involved in epidermal keratinocyte differentiation and skin barrier repair in man
Differentiation. 2021 Apr 30;119:19-27. doi: 10.1016/j.diff.2021.04.001. Online ahead of print.ABSTRACTA proper skin barrier function requires constant formation of stratum corneum, i.e. the outermost layer of epidermis composed of terminally differentiated keratinocytes. The complex process of converting proliferative basal keratinocytes into corneocytes relies on programmed changes in the activity of many well-established genes. Much remains however to be investigated about this process, e.g. in conjunction with epidermal barrier defects due to genetic errors as in ichthyosis. To this end, we re-analyzed two sets of micr...
Source: Differentiation - May 24, 2021 Category: Research Authors: Hanqian Zhang Simone Westr öm Per Kappelin Marie Virtanen Anders Vahlquist Hans T örmä Source Type: research
TRPC1 ‐mediated Ca2+ signaling enhances intestinal epithelial restitution by increasing α4 association with PP2Ac after wounding
AbstractGut epithelial restitution after superficial wounding is an important repair modality regulated by numerous factors including Ca2+ signaling and cellular polyamines. Transient receptor potential canonical-1 (TRPC1) functions as a store-operated Ca2+ channel in intestinal epithelial cells (IECs) and its activation increases epithelial restitution by inducing Ca2+ influx after acute injury. α4 is a multiple functional protein and implicated in many aspects of cell functions by modulating protein phosphatase 2A (PP2A) stability and activity. Here we show that the clonal populations of IECs stably expressing TRPC1 (IE...
Source: Physiological Reports - May 15, 2021 Category: Physiology Authors: Navneeta Rathor,
Hee Kyoung Chung,
Jia ‐Le Song,
Shelley R. Wang,
Jian‐Ying Wang,
Jaladanki N. Rao Tags: ORIGINAL ARTICLE Source Type: research
BYHWD Alleviates Inflammatory Response by NIK-Mediated Repression of the Noncanonical NF- κB Pathway During ICH Recovery
Intracerebral hemorrhage (ICH) is a life-threatening type of stroke that lacks effective treatments. The inflammatory response following ICH is a vital response that affects brain repair and organism recovery. The nuclear factor κB (NF-κB) signaling pathway is considered one of the most important inflammatory response pathways and one of its response pathways, the noncanonical NF-κB signaling pathway, is known to be associated with persistent effect and chronic inflammation. NF-κB–inducing kinase (NIK) via the noncanonical NF-κB signaling plays a key role in controlling inflammation. Here, we investigated potential ...
Source: Frontiers in Pharmacology - May 7, 2021 Category: Drugs & Pharmacology Source Type: research
Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore
We present in vivo pharmacokinetic studies of the top analogues with evidence of brain penetration. We also report a targeted siRNA-based screen which suggests a possible role for mTOR and Akt in DNA repair inhibition by this class of drugs. Taken together, these data reveal a new class of mibefradil-based DNA repair inhibitors which can be further advanced into pre-clinical testing and eventually clinical trials, as potential GBM radiosensitizers.PMID:33953843 | PMC:PMC8092340 | DOI:10.18632/oncotarget.27933
Source: Oncotarget - May 6, 2021 Category: Cancer & Oncology Authors: Sateja Paradkar James Herrington Adam Hendricson Piyasena Hewawasam Mark Plummer Denton Hoyer Ranjini K Sundaram Yulia V Surovtseva Ranjit S Bindra Source Type: research
