Illuminating the route of precision medicine and inhibitor discovery: real-time measurement of DNA repair capacity with molecular beacons.
Authors: Bellacosa A, Yen T PMID: 30627317 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 11, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

New developments of metformin in the clinical cancer area.
Authors: Berstein LM PMID: 30627318 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 11, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Unraveling the genomic determinants of response to CDK4/6 inhibitors.
Authors: Litchfield LM, Webster VW, Buchanan SG PMID: 30627319 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 11, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

How I treat rituximab refractory patients with WM.
Authors: Gavriatopoulou M, Ntanasis-Stathopoulos I, Kastritis E, Dimopoulos MA PMID: 30627320 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 11, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Time to go functional! Determining tumors' DNA repair capacity ex vivo.
Authors: Tumiati M, Hietanen S, Kauppi L PMID: 30627321 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 11, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Role of ASXL1 mutation in impaired hematopoiesis and cellular senescence.
Authors: Uni M, Kurokawa M PMID: 30627322 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 11, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Heparanase inhibitors restrain mesothelioma.
Authors: Lapidot M, Barash U, Vlodavsky I, Pass H Abstract Malignant mesothelioma is a highly aggressive form of cancer with poor prognosis due to lack of markers for early diagnosis and resistance to conventional therapies. Heparanase, the sole heparan sulfate (HS) degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, metastasis, angiogenesis, and inflammation. Heparanase accomplishes this by degrading HS and thereby facilitating cell invasion and regulating the bioavailability of heparin-binding proteins. Applying pre-clinical and clinical models of human mesothelioma and ...
Source: Oncotarget - January 11, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Novel screen for anti-cancer drugs that elevate chromosome instability (CIN) using human artificial chromosome (HAC).
Authors: Kouprina N, Pommier Y, Larionov V Abstract Human artificial chromosomes (HACs) bearing functional kinetochores have been exploited as promising systems for gene delivery and expression and in studies of different epigenetic modifications on kinetochore structure and function. The HAC-based technology has been also used to develop drug screening and assessment strategies to manipulate the CIN (chromosome instability) phenotype in cancer cells. More recently, we designed a new protocol for systematic analysis of compounds specifically targeting telomeres and telomerase. This approach used two isogenic cell l...
Source: Oncotarget - January 11, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Integrated landscape of copy number variation and RNA expression associated with nodal metastasis in invasive ductal breast carcinoma.
Conclusions: Gains in CTAGE5, NDUFC2, EIF4EBP1, and PSCA genes and their expression may aid in early diagnosis of metastatic breast carcinoma and have potential as therapeutic targets. PMID: 30627325 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 11, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Thioredoxin interacting protein promotes invasion in hepatocellular carcinoma.
Authors: Gunes A, Bagirsakci E, Iscan E, Cakan-Akdogan G, Aykutlu U, Senturk S, Ozhan G, Erdal E, Nart D, Barbet FY, Atabey N Abstract Background: Considerable evidence suggests that oxidative stress plays an essential role in the progression of hepatocellular carcinoma (HCC). While acquired resistance to oxidative stress is the main driver of aggressive cell phenotype, the underlying mechanisms remain unknown. Here, we tested the hypothesis that elevated expression of Thioredoxin-interacting protein (TXNIP) is a main regulator of the aggressive phenotype in HCC. Materials and Methods: To test this hypothesis, ...
Source: Oncotarget - January 11, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Eradication of LIG4-deficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent.
In conclusion, PARP inhibitor combined with DNA damage inducing agents can be utilized in patients with glioblastoma displaying defects in D-NHEJ. PMID: 30627327 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 11, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Analysis of mutations in primary and metastatic synovial sarcoma.
Authors: Xing Z, Wei L, Jiang X, Conroy J, Glenn S, Bshara W, Yu T, Pao A, Tanaka S, Kawai A, Choi C, Wang J, Liu S, Morrison C, Yu YE Abstract Synovial sarcoma is the most common pediatric non-rhabdomyosarcoma soft tissue sarcoma and accounts for about 8-10% of all soft tissue sarcoma in childhood and adolescence. The presence of a chromosomal translocation-associated SS18-SSX-fusion gene is causally linked to development of primary synovial sarcoma. Metastases occur in approximately 50-70% of synovial sarcoma cases with yet unknown mechanisms, which led to about 70-80% mortality rate in five years. To explore the...
Source: Oncotarget - January 11, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

PRMT5 inhibitors on the (myeloma) road.
Authors: Gulla A, Hideshima T, Anderson KC PMID: 30613345 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The dual effect of pharmacological ascorbate on radiation: The best of both worlds.
Authors: Cullen JJ PMID: 30613346 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Prostate cancer genomics and racial health disparity.
Authors: Hayes VM, Jaratlerdsiri W, Bornman MSR PMID: 30613347 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Targeting Her2/neu in uterine serous carcinoma: A paradigm shift in management.
Authors: Lopez S, Zeybek B, Santin AD PMID: 30613348 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Genomic loss of heterozygosity and survival in the REAL3 trial.
Conclusion: HRD assessment using an algorithmically derived LOH signature on a standard NGS panel identifies oesophagogastric cancer patients with high LOH who have prolonged survival when treated with platinum chemotherapy. Validation work will determine the signature's predictive value in patients treated with a PARP inhibitor and with platinum chemotherapy. PMID: 30613349 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues.
Authors: Muccioli M, Nandigam H, Loftus T, Singh M, Venkatesh A, Wright J, Pate M, McCall K, Benencia F Abstract Inflammation and cancer are inter-related, and both pro- and anti-tumorigenic effects are possible in different contexts, highlighting the importance of characterizing specific inflammatory pathways in distinct tumor types. Malignant cells and non-cancerous cells such as fibroblasts, infiltrating leukocytes (i.e., dendritic cells [DC], macrophages, or lymphocytes) and endothelial cells, in combination with the extracellular matrix, constitute the tumor microenvironment (TME). In the last decades, the rol...
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

SOX2 haploinsufficiency promotes impaired vision at advanced age.
Authors: Moreno-Cugnon L, Anasagasti A, Ezquerra-Inchausti M, Izeta A, de la Villa P, Ruiz-Ederra J, Matheu A Abstract Age-related vision loss has been associated with degeneration of the retina and decline in Müller glia cell activity. Sox2 is a critical transcription factor for the development and maintenance of the mammalian retina. Here we determined the role of Sox2 in retinal aging. We observed a decline in the number of Sox2-positive Müller, amacrine and ganglion cells with age. We also explored the impact of Sox2 haploinsufficiency (Sox2GFP ) on the activity of Müller glia cells and vision lo...
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Exploiting the transcriptional specificity of the alpha-methylacyl-CoA racemase AMACR promoter for the molecular imaging of prostate cancer.
Authors: Shapovalova M, Davydova J, Henzler C, Daniel M, Dehm SM, Warlick CA, LeBeau AM Abstract The metabolic protein alpha-methylacyl-CoA racemase (AMACR) is significantly overexpressed in prostate cancer compared to the normal prostate and other non-malignant tissue. Though an attractive target, there are no reports in the literature on leveraging the expression of AMACR for the molecular imaging of prostate cancer. Here, we used a molecular-genetic imaging strategy to exploit the transcriptional specificity of the AMACR promoter for the in vivo detection of prostate cancer using the reporter gene luciferase. We...
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer.
Authors: Shailesh H, Zakaria ZZ, Baiocchi R, Sif S Abstract Protein arginine methyltransferases (PRMTs) are known for their ability to catalyze methylation of specific arginine residues in a wide variety of cellular proteins, which are involved in a plethora of processes including signal transduction, transcription, and more recently DNA recombination. All members of the PRMT family can be grouped into three main classes depending on the type of methylation they catalyze. Type I PRMTs induce monomethylation and asymmetric dimethylation, while type II PRMTs catalyze monomethylation and symmetric dimethylation of spe...
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Correction: Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height.
Authors: Tatton-Brown K, Hanks S, Ruark E, Zachariou A, Del Vecchio Duarte S, Ramsay E, Snape K, Murray A, Perdeaux ER, Seal S, Loveday C, Banka S, Clericuzio C, Flinter F, Magee A, McConnell V, Patton M, Raith W, Rankin J, Splitt M, Strenger V, Taylor C, Wheeler P, Temple IK, Cole T, Childhood Overgrowth Collaboration, Douglas J, Rahman N Abstract [This corrects the article DOI: 10.18632/oncotarget.385.]. PMID: 30613354 [PubMed - in process] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Correction 2: Everolimus (EVE) and exemestane (EXE) in patients with advanced breast cancer aged ≥ 65 years: new lessons for clinical practice from the EVA study.
Correction 2: Everolimus (EVE) and exemestane (EXE) in patients with advanced breast cancer aged ≥ 65 years: new lessons for clinical practice from the EVA study. Oncotarget. 2018 Nov 30;9(94):36720-36721 Authors: Cazzaniga M, Verusio C, Ciccarese M, Fumagalli A, Sartori D, Valerio MR, Airoldi M, Moretti G, Ficorella C, Arcangeli V, Diodati L, Zambelli A, Febbraro A, Generali D, Pistelli M, Garrone O, Musolino A, Vici P, Maur M, Mentuccia L, La Verde N, Bianchi G, Artale S, Blasi L, Piezzo M, Atzori F, Turletti A, Benedetto C, Cursano MC, Fabi A, Gebbia V, Schirone A, Palumbo R, Ferzi A, Frassoldati A, Scav...
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Heterogeneity in the lymphocytic infiltration of deficient DNA mismatch repair colon cancers.
Authors: Yoon HH, Sinicrope FA PMID: 30613356 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

USP27X, a new player on EMT and fibroblast activation.
Authors: Díaz VM PMID: 30613357 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Targeting the STAT5 pathway in Ph+ acute lymphoblastic leukemia.
Authors: Minieri V, De Dominici M, Nevalainen MT, Calabretta B PMID: 30613358 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Towards personalized chemotherapy of acute lymphoblastic leukemia.
Authors: Hnízda A, Yang T PMID: 30613359 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Targeting FHL2 for EGFRvIII-positive glioblastoma.
Authors: Sun L, Lan Q, Li M PMID: 30613360 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly.
Authors: Lerche S, Brockmann K PMID: 30613361 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Transcriptional regulation of mTORC1 in cancer.
Authors: Di Malta C, Ballabio A PMID: 30613362 [PubMed] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Expression and potential role of cellular retinol binding protein I in psoriasis.
Authors: Costanza G, Doldo E, Ferlosio A, Tarquini C, Passeri D, Cascella R, Bavetta M, Di Stefani A, Bonifati C, Agostinelli S, Centofanti F, Giardina E, Campione E, Bianchi L, Donati P, Morrone A, Orlandi A Abstract Psoriasis is a diffuse chronic skin disorder characterized from accelerated epidermal turnover and inflammatory cell infiltrate. Retinoids influence keratinocyte proliferation and differentiation as well as inflammatory response. Cellular retinol binding protein (CRBPI) regulates intracellular vitamin A bioavailability and contributes to maintain skin homeostasis. The aim of present study was to inves...
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

ZNF350 promoter methylation accelerates colon cancer cell migration.
In this study, we isolated a subpopulation with accelerated baseline motility (MG cells) and an immotile one (non-MG cells) from a colon cancer cell line (HCT116). Gene expression signatures of the MG cells indicated that this subpopulation was likely an EMT hybrid. The MG cells substantially lost their migratory properties after treatment with a methyltransferase inhibitor, 5-azacytidine, suggesting a role of DNA methylation in this process. Global transcriptome assays of both types of cells with or without 5-azacytidine treatment identified 640 genes, whose expression might be methylation-dependently down-regulated in th...
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

POU4F2/Brn-3b transcription factor is associated with survival and drug resistance in human ovarian cancer cells.
In this study, we demonstrate that the Brn-3b transcription factor was increased in different ovarian cancer cells including SKOV3 and A2780 following treatment with cis and pax. Furthermore, sustained increases in Brn-3b were associated with survival in drug resistant cells and correlated with elevated HSP27 expression. In contrast, targeting Brn-3b for reduction using short interfering RNA (siRNA) also resulted in attenuated HSP27 expression. Importantly, blocking Brn-3b expression with siRNA in SKOV3 cells was associated with reduced cell numbers at baseline but also increased cell death after further treatment, indicat...
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Targeting the Wnt/ β-catenin pathway in human osteosarcoma cells.
Targeting the Wnt/β-catenin pathway in human osteosarcoma cells. Oncotarget. 2018 Dec 04;9(95):36780-36792 Authors: Fang F, VanCleave A, Helmuth R, Torres H, Rickel K, Wollenzien H, Sun H, Zeng E, Zhao J, Tao J Abstract Aberrant activation of Wnt signaling has been implicated in human osteosarcoma, which may provide a genetic vulnerability that can be targeted in osteosarcoma treatment. To test whether Wnt activation is necessary for osteosarcoma growth, colony formation, invasion, and metastasis, we treated human osteosarcoma cells with a small molecule inhibitor of Wnt/β-catenin, PRI-724, w...
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Target sequencing of cancer-related genes in early esophageal squamous neoplasia resected by endoscopic resection in Japanese patients.
Authors: Kobayashi S, Yamaguchi T, Maekawa S, Takano S, Kuno T, Tanaka K, Tsukui Y, Iwamoto F, Yoshida T, Asakawa Y, Fukasawa M, Nakayama Y, Inoue T, Uetake T, Sakamoto M, Ohtaka M, Sato T, Enomoto N Abstract Background and Aims: Next generation sequencing (NGS) has revealed a great deal about cancer-related somatic changes in esophageal squamous cell neoplasia; however, the changes in the very early stages remain unclear. Results: TP53 (87%) and CDKN2A (20%) hot spot mutations were frequently found in early lesions. TP53 was the most common mutation (LGIN/HGIN, 86%; EP, 83%; LPM, 95%; MM/SM1, 80%), followed by...
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Tubulin couples death receptor 5 to regulate apoptosis.
Authors: Twomey JD, Zhao L, Luo S, Xu Q, Zhang B Abstract Activation of death receptor 5 (DR5) to induce apoptosis in cancer cells is an attractive strategy for cancer therapy. However, many tumor cell lines and primary tumors are resistant to DR5 targeted agents including recombinant tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and anti-DR5 agonistic antibodies. Here we identify tubulin proteins - primarily consisting of α and β subunits folded into microtubule polymers - as a crucial modulator of DR5 mediated apoptosis. Using affinity purification coupled with mass spectrometry...
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Correction: Cutaneous melanoma primary site is linked to nevus density.
Authors: Martin-Gorgojo A, Llinares M, Virós A, Requena C, Garcia-Casado Z, Traves V, Kumar R, Nagore E Abstract [This corrects the article DOI: 10.18632/oncotarget.22016.]. PMID: 30613369 [PubMed - in process] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Correction: Identification of neoepitopes recognized by tumor-infiltrating lymphocytes (TILs) from patients with glioma.
Authors: Valentini D, Rao M, Meng Q, von Landenberg A, Bartek J, Sinclair G, Paraschoudi G, Jäger E, Harvey-Peredo I, Dodoo E, Maeurer M Abstract [This corrects the article DOI: 10.18632/oncotarget.24955.]. PMID: 30613370 [PubMed - in process] (Source: Oncotarget)
Source: Oncotarget - January 8, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

CLAG-M with dose-escalated mitoxantrone for adults with acute myeloid leukemia.
Authors: Halpern AB, Walter RB PMID: 30564292 [PubMed] (Source: Oncotarget)
Source: Oncotarget - December 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Cancer immunotherapy: Moving beyond checkpoint inhibition.
Authors: Boes M PMID: 30564293 [PubMed] (Source: Oncotarget)
Source: Oncotarget - December 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Genomic biomarker of checkpoint efficacy, highways for precision medicine in lung cancer.
Authors: Ghiringhelli F, Truntzer C PMID: 30564294 [PubMed] (Source: Oncotarget)
Source: Oncotarget - December 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Using genomics to better define high-risk MGUS/SMM patients.
Authors: Dutta AK, Hewett DR, Fink JL, Zannettino ACW PMID: 30564295 [PubMed] (Source: Oncotarget)
Source: Oncotarget - December 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

IGFBP2 is a potential biomarker in acute kidney injury (AKI) and resveratrol-loaded nanoparticles prevent AKI.
This study aims to determine whether insulin-like growth factor binding protein2 (IGFBP2) is a useful biomarker for early diagnosis of acute kidney injury (AKI), evaluate the therapeutic effects of resveratrol-loaded nanoparticles (Res-NPs), and investigate the possible underlying mechanisms in a rat model of AKI induced by IRI. Forty male Sprague-Dawley rats were randomly divided into four groups (10 animals per group): sham, IRI control, resveratrol, and Res-NPs injection. Kidney injury and the effects of Resveratrol and Res-NPs were determined by histological examination, renal function, cell apoptosis profile, and gene...
Source: Oncotarget - December 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma.
Authors: Matsushima-Otsuka S, Fujiwara-Tani R, Sasaki T, Ohmori H, Nakashima C, Kishi S, Nishiguchi Y, Fujii K, Luo Y, Kuniyasu H Abstract The renin-angiotensin system (RAS) is implicated in the maintenance of blood pressure and in many other biological processes including tumorigenesis and metastasis formation. Angiotensin-II (A-II) type 2 receptor (AGTR2) seems to be involved in different types of cancer; its role, however, is still unclear. Here, we investigated the role of RAS, and specifically that of AGTR2, in oral squamous cell carcinoma (OSCC) progression. AGTR2 has opposite effect on vasodilation and blood...
Source: Oncotarget - December 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Preoperative diffusion-weighted magnetic resonance imaging and intraoperative frozen sections for predicting the tumor grade in endometrioid endometrial cancer.
Conclusion: A FS diagnosis is more suitable for predicting high-grade tumors than DW-MRI; however, physicians should pay close attention to tumors with low ADC values on preoperative DW-MRI. PMID: 30564298 [PubMed] (Source: Oncotarget)
Source: Oncotarget - December 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Co-treatment of tumor cells with hyaluronan plus doxorubicin affects endothelial cell behavior independently of VEGF expression.
Authors: Vitale DL, Spinelli FM, Del Dago D, Icardi A, Demarchi G, Caon I, García M, Bolontrade MF, Passi A, Cristina C, Alaniz L Abstract Hyaluronan, the main glycosaminoglycan of extracellular matrices, is concentrated in tissues with high cell proliferation and migration rates. In cancer, hyaluronan expression is altered and it becomes fragmented into low-molecular-weight forms, affecting mechanisms associated with cell proliferation, invasion, angiogenesis and multidrug resistance. Here, we analyzed the effect of low-molecular-weight hyaluronan on the response of T lymphoma, osteosarcoma, and mammary ade...
Source: Oncotarget - December 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Clofarabine/busulfan-based reduced intensity conditioning regimens provides very good survivals in acute myeloid leukemia patients in complete remission at transplant: a retrospective study on behalf of the SFGM-TC.
Conclusions: CloB2A2/A1 RIC regimen provides very good results for AML patients allografted in CR and could be retained as a new RIC platform for these patients. Materials and Methods: This was a retrospective study including all patients who received a clofarabine/busulfan based RIC allo-SCT for myeloid malignancies and reported within the SFGM-TC registry. RIC regimen consisted of clofarabine 30 mg/m2/day 4 to 5 days (Clo), busulfan 3.2 mg/kg/day 2 days (B2) and 2.5 mg/kg/day of rabbit anti-thymocyte globulin 1 or 2 days (A1 or A2). The primary objective of the study was to report the main outcomes of the whole cohor...
Source: Oncotarget - December 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Clinical impact of measurable residual disease monitoring by ultradeep next generation sequencing in NPM1 mutated acute myeloid leukemia.
Authors: Patkar N, Kodgule R, Kakirde C, Raval G, Bhanshe P, Joshi S, Chaudhary S, Badrinath Y, Ghoghale S, Kadechkar S, Khizer SH, Kannan S, Shetty D, Gokarn A, Punatkar S, Jain H, Bagal B, Menon H, Sengar M, Khattry N, Tembhare P, Subramanian P, Gujral S Abstract Detection of measurable residual disease (MRD) by mutation specific techniques has prognostic relevance in NPM1 mutated AML (NPM1 mut AML). However, the clinical utility of next generation sequencing (NGS) to detect MRD in AML remains unproven. We analysed the clinical significance of monitoring MRD using ultradeep NGS (NGS-MRD) and flow cytometry (FCM-M...
Source: Oncotarget - December 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Meta-analysis of the likelihood of FOXC1 expression in early- and late-stage tumors.
Conclusions: The results from our meta-analysis of 5 studies indicate that FOXC1 is 23.8% more likely to be expressed in late-stage tumors than in early-stage tumors. PMID: 30564302 [PubMed] (Source: Oncotarget)
Source: Oncotarget - December 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Tumour treating fields in a combinational therapeutic approach.
Authors: Branter J, Basu S, Smith S Abstract The standard of care for patients with newly diagnosed Glioblastoma multiforme (GBM) has remained unchanged since 2005, with patients undergoing maximal surgical resection, followed by radiotherapy plus concomitant and maintenance Temozolomide. More recently, Tumour treating fields (TTFields) therapy has become FDA approved for adult recurrent and adult newly-diagnosed GBM following the EF-11 and EF-14 trials, respectively. TTFields is a non-invasive anticancer treatment which utilizes medium frequency alternating electric fields to target actively dividing cancerous cel...
Source: Oncotarget - December 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research