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Synergistic treatment of TS.
Authors: Gurkar AU, Finkel T PMID: 29027545 [PubMed] (Source: Oncotarget)
Source: Oncotarget - October 16, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Oncotarget[Journal]; +369 new citations
369 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Oncotarget[Journal] These pubmed results were generated on 2017/10/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Oncotarget)
Source: Oncotarget - October 7, 2017 Category: Cancer & Oncology Tags: Report Source Type: research

Estradiol-ER β2 signaling axis confers growth and migration of CRPC cells through TMPRSS2-ETV5 gene fusion.
We report that non-canonical activation of estradiol (E2)-ERβ2 signaling axis primes growth, colony-forming ability and migration of the androgen receptor (AR)-null castration-resistant PC (CRPC) cells under androgen-deprived conditions (ADC). The non-classical E2-ERβ2 mediates phosphorylation and activation of Src-IGF-1R complex, which in turn triggers p65-dependent transcriptional upregulation of the androgen-regulated serine protease TMPRSS2:ETV5a/TMPRSS2:ETV5b gene fusions under ADC. siRNA silencing of TMPRSS2 and/or ETV5 suggests that TMPRSS2:ETV5 fusions facilitates the E2-ERβ induced growth and migrat...
Source: Oncotarget - October 6, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

DNA-damage related genes and clinical outcome in hormone receptor positive breast cancer.
CONCLUSIONS: Expression of DNA metabolic related genes RAD51, GINS1, TRIP13 and MCM2 are associated with poor outcome. Combinations of some of these genes are linked to poor RFS or OS in luminal A, B and ER+HER2- tumors. Evaluation of its predictive capacity in prospective studies is required. PMID: 28968952 [PubMed] (Source: Oncotarget)
Source: Oncotarget - October 6, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

BRIP1 coding variants are associated with a high risk of hepatocellular carcinoma occurrence in patients with HCV- or HBV-related liver disease.
Authors: Oussalah A, Avogbe PH, Guyot E, Chery C, Guéant-Rodriguez RM, Ganne-Carrié N, Cobat A, Moradpour D, Nalpas B, Negro F, Poynard T, Pol S, Bochud PY, Abel L, Jeulin H, Schvoerer E, Chabi N, Amouzou E, Sanni A, Barraud H, Rouyer P, Josse T, Goffinet L, Jouve JL, Minello A, Bonithon-Kopp C, Thiefin G, Di Martino V, Doffoël M, Richou C, Raab JJ, Hillon P, Bronowicki JP, Guéant JL, CiRCE Study Group Abstract The molecular mechanisms of hepatocellular carcinoma (HCC) carcinogenesis are still not fully understood. DNA repair defects may influence HCC risk. The aim of the study was to look...
Source: Oncotarget - October 6, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Positive expression of NR6A1/CT150 as a predictor of biochemical recurrence-free survival in prostate cancer patients.
Authors: Cheng G, Wang S, Li X, Li S, Zheng Y, Zhang L, Bao M, Liang C, Huang Z, Liu Y, Qin C, Shao P, Li J, Hua L, Yin C, Wang Z Abstract NR6A1/CT150, as an orphan receptor, is a novel member of the cancer-testis (CT) antigen family. Here, we investigated the expression and function of NR6A1 and its underlying mechanisms in prostate cancer (PCa) patients who underwent radical prostatectomy. A total of 303 cases of prostate cancer after radical prostatectomy were analysed in a tissue microarray (TMA) for NR6A1 immunohistochemistry-based protein expression. Kaplan-Meier/log-rank analysis and Cox regression analysis ...
Source: Oncotarget - October 6, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Oncotarget[Journal]; +149 new citations
149 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Oncotarget[Journal] These pubmed results were generated on 2017/10/04PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Oncotarget)
Source: Oncotarget - October 4, 2017 Category: Cancer & Oncology Tags: Report Source Type: research

Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.
In this study, we analysed the LOX expression patterns in the nuclei of rectal cancer patient samples and determined the clinical significance of this expression. Nuclear LOX expression was significantly increased in patient lymph node metastases compared to their primary tumours. High nuclear LOX expression in tumours was correlated with a high rate of distant metastasis and increased recurrence. Multivariable analysis showed that high nuclear LOX expression was also correlated with poor overall survival and disease free survival. Furthermore, we are the first to identify LOX enzyme isoforms (50 kDa and 32 kDa) within the...
Source: Oncotarget - September 30, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

TriCurin, a novel formulation of curcumin, epicatechin gallate, and resveratrol, inhibits the tumorigenicity of human papillomavirus-positive head and neck squamous cell carcinoma.
Authors: Piao L, Mukherjee S, Chang Q, Xie X, Li H, Castellanos MR, Banerjee P, Iqbal H, Ivancic R, Wang X, Teknos TN, Pan Q Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide with about 600,000 new cases diagnosed in the last year. The incidence of human papillomavirus-positive head and neck squamous cell carcinoma (HPV-positive HNSCC) has rapidly increased over the past 30 years prompting the suggestion that an epidemic may be on the horizon. Therefore, there is a clinical need to develop alternate therapeutic strategies to manage the growing number of HPV-positive...
Source: Oncotarget - September 30, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The inhibitory effect of 7,7 ″-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization.
The inhibitory effect of 7,7″-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization. Oncotarget. 2017 Sep 01;8(36):60046-60059 Authors: Lin CM, Lin YL, Ho SY, Chen PR, Tsai YH, Chung CH, Hwang CH, Tsai NM, Tzou SC, Ke CY, Chang J, Chan YL, Wang YS, Chi KH, Liao KW Abstract 7,7″-Dimethoxyagastisflavone (DMGF), a biflavonoid isolated from Taxus × media cv. Hicksii, induces apoptotic and autophagic cell death. However, whether DMGF suppresses tumor metastasis is unclear. The aim of this study was to investigate the anti-metastatic activ...
Source: Oncotarget - September 30, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Preoperative short- vs. long-course chemoradiotherapy with delayed surgery for locally advanced rectal cancer.
CONCLUSIONS: Preoperative short-course CRT is an effective and safe modality. It is clinically comparable to long-course CRT in locally advanced rectal cancer. PMID: 28947986 [PubMed] (Source: Oncotarget)
Source: Oncotarget - September 30, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Spectrum of BRCA1/2 variants in 940 patients from Argentina including novel, deleterious and recurrent germline mutations: impact on healthcare and clinical practice.
CONCLUSION: a) this first comprehensive description of the spectrum in BRCA1/2 sheds light on the low frequency of recurrent mutations; b) this information is key in clinical practice to select adequate sequencing studies in our population, subsequently improve patient outcome and prevent damage associated to false normal reports resulting from the use of invalid population panels; c) panels of mutations from other populations should be cautiously validated before imported, even those of apparently similar origin, a concept to be considered beyond significance in Argentina. PMID: 28947987 [PubMed] (Source: Oncotarget)
Source: Oncotarget - September 30, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Identification of SRF-E2F1 fusion transcript in EWSR-negative myoepithelioma of the soft tissue.
Authors: Urbini M, Astolfi A, Indio V, Tarantino G, Serravalle S, Saponara M, Nannini M, Gronchi A, Fiore M, Maestro R, Brenca M, Dei Tos AP, Dagrada GP, Negri T, Pilotti S, Casali PG, Biasco G, Pession A, Stacchiotti S, Pantaleo MA Abstract Myoepithelial neoplasms (MN) are rare and not well-circumstanced entities displaying a heterogeneous spectrum of genetic abnormalities, including EWSR1, FUS and PLAG1 rearrangements. However, in the remaining MN no other fusion gene has been described and knowledge concerning secondary acquired molecular alterations is still poor. Therefore, we screened 5 cases of MN of the sof...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells.
Authors: Sulkshane P, Teni T Abstract We have previously reported overexpression of antiapoptotic MCL-1 protein in human oral cancers and its association with therapy resistance and poor prognosis, implying it to be a potential therapeutic target. Hence, we investigated the efficacy and mechanism of action of Obatoclax, a BH3 mimetic pan BCL-2 inhibitor in human oral cancer cell lines. All cell lines exhibited high sensitivity to Obatoclax with complete clonogenic inhibition at 200-400 nM concentration which correlated with their MCL-1 expression. Mechanistic insights revealed that Obatoclax induced a caspase-indep...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

1,25D3 differentially suppresses bladder cancer cell migration and invasion through the induction of miR-101-3p.
Authors: Ma Y, Luo W, Bunch BL, Pratt RN, Trump DL, Johnson CS Abstract Metastasis is the major cause of bladder cancer death. 1,25D3, the active metabolite of vitamin D, has shown anti-metastasis activity in several cancer model systems. However, the role of 1,25D3 in migration and invasion in bladder cancer is unknown. To investigate whether 1,25D3 affects migration and invasion, four human bladder cell lines with different reported invasiveness were selected: low-invasive T24 and 253J cells and highly invasive 253J-BV and TCCSUP cells. All of the four bladder cancer cells express endogenous and inducible vitamin...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Non-V600 BRAF mutations recurrently found in lung cancer predict sensitivity to the combination of Trametinib and Dabrafenib.
This study provides a basis for the clinical exploration of non-V600 BRAF mutant lung cancers upon treatment with Trametinib and Dabrafenib. PMID: 28947956 [PubMed] (Source: Oncotarget)
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Cooperative but distinct early co-signaling events originate from ERBB2 and ERBB1 receptors upon trastuzumab treatment in breast cancer cells.
In conclusion, here we show for the first time an ERBB2-specific signaling contribution to an ERBB2/ERBB1 heterodimer, in the activation of a complex biological process such as the formation of CDRs. PMID: 28947957 [PubMed] (Source: Oncotarget)
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Crosstalk between tongue carcinoma cells, extracellular vesicles, and immune cells in in vitro and in vivo models.
This study describes promising in vitro and in vivo models to investigate interactions between immune cells, cancer cells, and EVs. PMID: 28947958 [PubMed] (Source: Oncotarget)
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

ColXV promotes adipocyte differentiation via inhibiting DNA methylation and cAMP/PKA pathway in mice.
In this study, high fat diet (HFD) fed mice were used as obese model, in which we deeply investigated the interaction between ColXV and adipocyte differentiation or adipose metabolism. We found great elevated ColXV expression and positive effect of ColXV on lipid deposition during adipocyte differentiation or obesity both in vitro and in vivo. cAMP response element binding protein (CREB) is a cellular transcription factor that can inhibit adipogenesis and promote lipolysis. Here we proposed ColXV as a newly discovered downstream gene of CREB. We further proved that CREB can repress adipocyte differentiation and enhance lip...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Exosome-encapsulated microRNAs as circulating biomarkers for colorectal cancer.
Authors: Yan S, Han B, Gao S, Wang X, Wang Z, Wang F, Zhang J, Xu D, Sun B Abstract Currently available studies have suggested that a number of exosome-encapsulated microRNAs (miRNAs) are recognized as stable biomarkers for cancers. However, little is known about the effect of exosomal miRNAs on colorectal cancer (CRC). The aim of study is to identify specific miRNAs in serum exosomes, which may serve as potential diagnostic and prognostic biomarkers and therapeutic targets for CRC. Microarray analyses of miRNAs in serum exosomes from 3 primary CRC patients and 3 healthy controls were performed. Those differentiall...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Phorbol esters dPPA/dPA promote furin expression involving transcription factor CEBP β in neuronal cells.
Phorbol esters dPPA/dPA promote furin expression involving transcription factor CEBPβ in neuronal cells. Oncotarget. 2017 Sep 01;8(36):60159-60172 Authors: Zha JS, Zhu BL, Liu L, Lai YJ, Long Y, Hu XT, Deng XJ, Wang XF, Yan Z, Chen GJ Abstract Using high-throughput small molecule screening targeting furin gene, we identified that phorbol esters dPPA (12-Deoxyphorbol 13-phenylacetate 20-acetate) and dPA (12-Deoxyphorbol 13-acetate) significantly increased furin protein and mRNA expression in SH-SY5Y cells. This effect was prevented by PKC (protein kinase C) inhibitor calphostin C but not Ro318220, ...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

5-Azacytidine promotes invadopodia formation and tumor metastasis through the upregulation of PI3K in ovarian cancer cells.
In this study, we found that the inhibition of methylation by 5-AZ (5-Azacytidine) increased the formation of invadopodia and enhanced degradation of the extracellular matrix in ovarian cancer cells. In mouse xenograft models, treatment with 5-AZ increased the number of metastatic nodules, which suggests an elevated potential for metastasis by demethylation. Further investigation indicated that the inhibition of methylation elevated the transcription of PIK3CA and upregulated genes involved in the PI3K-AKT signaling pathway. In addition, this induction likely occurs though the epigenetic regulation of PIK3CA because analys...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Flexible ligated ruthenium(II) self-assemblies sensitizes glioma tumor initiating cells in vitro.
Authors: Elumalai P, Kaushik N, Kim DH, Kim H, Lee SJ, Choi EH, Chi KW, Kaushik NK Abstract The tumorigenic potentials of residual cancer stem-like cells within tumors represent limitations of current cancer therapies. Here, the authors describe the effects of synthesized flexible, ligated, supramolecular self-assembled chair type tetranuclear ruthenium (II) metallacycles (2-5) on glioblastoma and glioma stem like cells. These self-assemblies were observed to be selectively toxic to glioma cells and CD133-positive glioma stem like cells population. Of the self-assembled compounds tested, metallacycle 4 more efficie...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Chinese medicine Ginseng and Astragalus granules ameliorate autoimmune diabetes by upregulating both CD4+FoxP3+ and CD8+CD122+PD1+ regulatory T cells.
This study may have important clinical implications for the treatment of T1DM using traditional Chinese medicine. PMID: 28947964 [PubMed] (Source: Oncotarget)
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Crosstalk between stromal components and tumor cells of TNBC via secreted factors enhances tumor growth and metastasis.
In this study, we determined that fibroblasts and macrophages secreted IL-8 upon induction by tumor cell-conditioned media (TCM) from MDA-MB-231 cancer cells. Our data showed that the proliferation of MDA-MB-231 cells co-cultured with fibroblasts or macrophages was enhanced compared to the monoculture. Furthermore, TNBC cell migration, a key step in tumor metastasis, was promoted by conditioned media (CM) from TCM-induced fibroblasts or macrophages. Knockdown of the IL-8 receptor CXCR2 by CRISPR-Cas9 reduces MDA-MB-231 cell proliferation and migration compared to wild type. In a mouse xenograft tumor model, the growth of M...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

TNF α affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics.
TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics. Oncotarget. 2017 Sep 01;8(36):60223-60242 Authors: Jensen P, Myhre CL, Lassen PS, Metaxas A, Khan AM, Lambertsen KL, Babcock AA, Finsen B, Larsen MR, Kempf SJ Abstract Neuroinflammation is a hallmark of Alzheimer's disease and TNFα as the main inducer of neuroinflammation has neurodegenerative but also pro-regenerative properties, however, the dose-dependent molecular changes on signaling pathway level are not fully understood. We performed quanti...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

miR-33a is a tumor suppressor microRNA that is decreased in prostate cancer.
Authors: Karatas OF, Wang J, Shao L, Ozen M, Zhang Y, Creighton CJ, Ittmann M Abstract Prostate cancer is one of the most frequently diagnosed neoplasms among men worldwide. MicroRNAs (miRNAs) are involved in numerous important cellular processes including proliferation, differentiation and apoptosis. They have been found to be aberrantly expressed in many types of human cancers. They can act as either tumor suppressors or oncogenes, and changes in their levels are associated with tumor initiation, progression and metastasis. miR-33a is an intronic miRNA embedded within SREBF2 that has been reported to have tumor s...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Characterization of infiltrating lymphocytes in human benign and malignant prostate tissue.
In conclusion, many prostate-infiltrating T-cells express co-inhibitory receptors PD-1 and LAG-3, regardless of prostate condition. Despite the observed increase in counts and percentages of PD-1(+) T-cells in PC, the concomitant demonstration of high percentage of PD-1(+) T-cells in control prostates suggests that PD-1 may play a role in controlling the homeostasis of the prostate rather than in contributing to PC-associated immune-suppression. Thus, PD-1 may not be a good candidate for checkpoint blockade in PC and these data are relevant for evaluation of clinical trials and in designing future immunotherapeutic approac...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Tumor repressor gene chondroadherin oppose migration and proliferation in hepatocellular carcinoma and predicts a good survival.
In conclusion, as a potential prognostic biomarker, tumor suppressor gene CHAD represses migration and proliferation of hepatocellular carcinoma cells, probability via mediating cell-cell adhesion. PMID: 28947969 [PubMed] (Source: Oncotarget)
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.
Authors: Pan RY, Liu P, Zhou HT, Sun WX, Song J, Shu J, Cui GJ, Yang ZJ, Jia EZ Abstract We investigated the differential expression of circular RNAs (circRNAs) in plasma samples from three coronary artery disease (CAD) patients to identify putative therapeutic targets. We identified 24 differentially expressed circRNAs (18 up-regulated and 6 down-regulated) and 7 differentially expressed mRNAs (6 up-regulated and 1 down-regulated) in CAD patients based on competing endogenous RNA (ceRNA) microarray analysis. MiR-221(p = 0.001), miR-155(p = 0.049), and miR-130a (p = 0.001) were downregulated in CAD patients based o...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Dynamic circulating tumor DNA quantificaton for the individualization of non-small-cell lung cancer patients treatment.
CONCLUSIONS: Monitoring levels of EGFR mutation in plasma allows resolving doubts that frequently arise in daily clinical practice and constitutes a major step towards achieving personalized medicine. PMID: 28947971 [PubMed] (Source: Oncotarget)
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

PGC1 α induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells.
PGC1α induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells. Oncotarget. 2017 Sep 01;8(36):60299-60311 Authors: Kim B, Jung JW, Jung J, Han Y, Suh DH, Kim HS, Dhanasekaran DN, Song YS Abstract Malignant cells are subjected to high levels of oxidative stress that arise from the increased production of reactive oxygen species (ROS) due to their altered metabolism. They activate antioxidant mechanisms to relieve the oxidative stress, and thereby acquire resistance to chemotherapeutic agents. In the present study, we found that PGC1α, a key molecule that both...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Hyperbaric oxygen protects type II collagen in interleukin-1 β-induced mandibular condylar chondrocyte via inhibiting the JNK/c-Jun signaling pathway.
Hyperbaric oxygen protects type II collagen in interleukin-1β-induced mandibular condylar chondrocyte via inhibiting the JNK/c-Jun signaling pathway. Oncotarget. 2017 Sep 01;8(36):60312-60323 Authors: Sun Q, Wu G, Chen H, Chen L, Chen H, Zhu G, Zhao H Abstract The aim of this study was to explore the mechanisms of Hyperbaric oxygen (HBO) protective on interleukin-1β (IL-1β) induced rat's mandibular condylar chondrocytes. Chondrocytes were exposure to Hyperbaric oxygen after induced inflammatory by IL-1β. After that, the expression of p-JNK and c-Jun was increased significantly, whil...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Selective cytotoxicity of vanadium complexes on human pancreatic ductal adenocarcinoma cell line by inducing necroptosis, apoptosis and mitotic catastrophe process.
Authors: Kowalski S, Hać S, Wyrzykowski D, Zauszkiewicz-Pawlak A, Inkielewicz-Stępniak I Abstract The pancreatic cancer is the fourth leading cause of cancer-related death and characterized by one of the lowest five-year survival rate. The current therapeutic options are demonstrating minimal effectiveness, therefore studies on new potential anticancer compounds, with non-significant side effects are highly desirable. Recently, it was demonstrated that vanadium compounds, in particular organic derivatives, exhibit anticancer properties against different type of tumor as well as favorable biodistribution from a pa...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway.
We report that phenformin (25-75 μM) decreased cell proliferation and impaired cell cycle progression in SKBR3 and 78617 breast cancer cells. Reduced tumor size after phenformin treatment (30 mg/kg/day) was demonstrated in an MMTV-ErbB2 transgenic mouse syngeneic tumor model. Phenformin also blocked epithelial-mesenchymal transition, decreased the invasive phenotype, and suppressed receptor tyrosine kinase signaling, including insulin receptor substrate 1 and IGF1R, in ErbB2-overexpressing breast cancer cells and mouse mammary tumor-derived tissues. Moreover, phenformin suppressed IGF1-stimulated proliferation, receptor...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Identification of hub genes involved in the development of hepatocellular carcinoma by transcriptome sequencing.
Authors: Zheng Y, Long J, Wu L, Zhang H, Li L, Zheng Y, Wang A, Lin J, Yang X, Sang X, Hu K, Pan J, Zhao H Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. The aim of this study was to identify underlying hub genes and dysregulated pathways associated with the development of HCC using bioinformatics analysis. Differentially expressed protein-coding genes were subjected to transcriptome sequencing in 11 pairs of liver cancer tissue and matched adjacent non-cancerous tissue. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were perfor...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Generation of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcoma.
In this study, we present evidence of the preclinical efficacy of a novel Antibody-Drug Conjugate (ENDOS/ADC). It consists of a humanized endosialin monoclonal antibody, named hMP-E-8.3, conjugated to a potent duocarmycin derivative. In endosialin expressing cancer cell lines, this ENDOS/ADC showed a powerful, specific and target-dependent killing activity. High expression levels of endosialin in cells correlated with efficient internalization and cytotoxic effects in vitro. Efficacy studies demonstrated that ENDOS/ADC treatment led to a long-lasting tumor growth inhibition of a cell line-based model of human osteosarcoma....
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

NOTCH1 activates the Wnt/ β-catenin signaling pathway in colon cancer.
CONCLUSION: NOTCH1 plays a key role in the Wnt pathway and activation of NOTCH1 is associated with the translocation of β-catenin to the nucleus. PMID: 28947978 [PubMed] (Source: Oncotarget)
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Effects of intensity-modulated radiotherapy and chemoradiotherapy on attention in patients with nasopharyngeal cancer.
This study evaluated the short-term effects of intensity-modulated radiotherapy (IMRT) and cisplatin concurrent chemo-radiotherapy (CCRT) on attention in patients with nasopharyngeal cancer (NPC). Timely detection and early prevention of cognitive decline are important in cancer patients, because long-term cognitive effects may be permanent and irreversible. Thirty-eight NPC patients treated with IMRT (17/38) or CCRT (21/38) and 38 healthy controls were recruited for the study. Neuropsychological tests were administered to each patient before treatment initiation and within a week after treatment completion. Changes in att...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Added value of diffusion weighted imaging in pediatric central nervous system embryonal tumors surveillance.
Authors: Morana G, Alves CA, Tortora D, Severino M, Nozza P, Cama A, Ravegnani M, D'Apolito G, Raso A, Milanaccio C, da Costa Leite C, Garrè ML, Rossi A Abstract Diffusion weighted imaging (DWI) has an established role in primary CNS embryonal tumor (ET) characterization; however, its diagnostic utility in detecting relapse has never been determined. We aimed to compare DWI and conventional MRI sensitivity in CNS ET recurrence detection, and to evaluate the DWI properties of contrast-enhancing radiation induced lesions (RIL). Fifty-six patients with CNS ET (25 with disease relapse, 6 with RIL and 25 with nei...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Lin28B facilitates the progression and metastasis of pancreatic ductal adenocarcinoma.
In this study, we explored the clinical significance of Lin28B in PDAC and its association with metastasis by examining tissues from patients with PDAC and elucidated the molecular mechanisms using PDAC cell lines. In patients, high Lin28B expression was significantly correlated with high levels of lymphatic metastasis, distant metastasis and a poor prognosis. Furthermore, the multivariate analysis identified Lin28B expression as an independent prognostic factor in patients. In cell lines, stable silencing of Lin28B inhibited cell proliferation, cell cycle transition, migration and the epithelial-mesenchymal transition (EM...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

BRWLDA: bi-random walks for predicting lncRNA-disease associations.
In this study, we developed a model that performs Bi-Random Walks to predict novel LncRNA-Disease Associations (BRWLDA in short). This model utilizes multiple heterogeneous data to construct the lncRNA functional similarity network, and Disease Ontology to construct a disease network. It then constructs a directed bi-relational network based on these two networks and available lncRNAs-disease associations. Next, it applies bi-random walks on the network to predict potential associations. BRWLDA achieves reliable and better performance than other comparing methods not only on experiment verified associations, but also on th...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Deceptive morphologic and epigenetic heterogeneity in diffuse intrinsic pontine glioma.
Authors: Bugiani M, van Zanten SEMV, Caretti V, Schellen P, Aronica E, Noske DP, Vandertop WP, Kaspers GJL, van Vuurden DG, Wesseling P, Hulleman E Abstract Historically, the diagnosis of diffuse intrinsic pontine glioma (DIPG) was based on typical imaging findings and clinical characteristics instead of pathology. However, the discovery of mutations in histone H3 variants, and the availability of tumor material for molecular analysis, has led to a paradigm shift in DIPG research and clinical practice. Using data from whole-brain autopsies in a series of nine DIPG patients with known histone mutational status, we h...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Drug resistance reversal in ovarian cancer cells of paclitaxel and borneol combination therapy mediated by PEG-PAMAM nanoparticles.
In this study, PTX and Borneol (BNL), a natural compound with P-gp inhibition effect confirmed in intestinal absorption, were co-loaded in the fabricated PEG-PAMAM nanoparticle (NPs) by a one-step nano-precipitation method with high drug loading efficiency, narrow size distribution and low hemolysis rate. Based on P-gp inhibition activity of BNL, confirmed by drug efflux test and molecular docking model, the combination of PTX and BNL could improve intracellular concentration of PTX in A2780/PTX cells. Furthermore, compared to both free PTX and PTX+BNL, PB/NPs and P/NPs plus BNL exhibited higher cellular uptake and cytotox...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Survey of urinary nickel in peritoneal dialysis patients.
This study surveyed urinary nickel concentrations in peritoneal dialysis (PD) patients, and analyzed the association of urinary nickel concentrations with clinical outcomes and inflammatory biomarkers. In total, 50 PD patients and 50 healthy controls were recruited for this study. All participants were examined for the presence of toxic trace elements (antimony, arsenic, bismuth, cadmium, copper, manganese, mercury, nickel, lead, tellurium, thallium and zinc) in their urine by using inductively coupled plasma mass spectrometry (ICP-MS). It was found that PD patients demonstrated higher urinary nickel concentrations than he...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Association analysis of APO gene polymorphisms with ischemic stroke risk: a case-control study in a Chinese Han population.
This study aimed to assess the association of APO gene polymorphisms and ischemic stroke risk in a Chinese Han population. In this case-control study, we genotyped 14 single nucleotide polymorphisms (SNPs) in 3 APO genes in 488 cases and 503 controls using Sequenom Mass-ARRAY technology and evaluated their association with ischemic stroke using the χ2 and genetic model analysis. In the allelic model analysis, we determined three SNPs were significantly associated with ischemic stroke: rs693 with a p value of 0.042 (OR = 1.406; 95%CI = 1.011-1.956), rs651821 with a p value of 0.007 (OR = 0.760; 95%CI = 0.622-0.929) and ...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Intensity-modulated radiotherapy has superior outcomes to three-dimensional conformal radiotherapy in patients with stage IE-IIE extranodal nasal-type natural killer/T-cell lymphoma.
Authors: Li YY, Lin HQ, Zhang LL, Feng LL, Niu SQ, Wang HY, Zhang YJ, Wang XC Abstract We compared the treatment outcomes, toxicities and prognoses of patients with stage IE-IIE extranodal natural killer/T-cell lymphoma (ENKTL) treated with intensity-modulated radiotherapy (IMRT) or three-dimensional conformal radiotherapy (3DCRT). Newly diagnosed early-stage ENKTL patients (N = 173) were enrolled and received extended involved-field radiotherapy following induction chemotherapy. Patients were treated with 3DCRT (n = 98) or IMRT (n = 75). One-to-one matching of the IMRT and 3DCRT groups was performed through propen...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer.
This study was aimed to examine the prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer (LSCC). From January 2007 to December 2011, 979 patients with LSCC were enrolled in our study. Preoperative neutrophils, platelets, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were analyzed. Besides well-established clinicopathological prognostic factors, we evaluated the independent prognostic relevance of these hematological parameters by Cox regr...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Plasma protein profiling in patients undergoing coronary artery bypass grafting surgery and clinical significance.
This study was designed to identify the protein profiling in patients with triple vessel coronary artery disease (CAD) undergoing CABG, in order to detect CAD-related differential proteins in these patients. CABG patients with triple vessel disease with/without left main stenosis (n =160) were compared to normal coronary angiographic subjects (n =160). Plasma samples of 20 males and 20 females in each group were analyzed with iTRAQ technique. ELISA test was used to test the chosen proteins from iTRAQ results in plasma samples from a new cohort of the CABG group (n=120, male/femal=61/59) and control (n =120, male/female=60/...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Expression, prognosis and functional role of Thsd7a in esophageal squamous cell carcinoma of Kazakh patients, Xinjiang.
Authors: Hou Z, Abudureheman A, Wang L, Hasim A, Ainiwaer J, Zhang H, Niyaz M, Upur H, Sheyhidin I Abstract Thsd7a (Thrombospondin type 1 domain containing 7a) is a critical transmembrane protein. Studies have indicated that Thsd7a was associated with cytoskeletal organization, cell migration and filopodia formation. However, the involvement of Thsd7a remains elusive in human Esophageal Squamous Cell Carcinoma (ESCC). Consequently, immunohistochemistry and reverse transcription-polymerase chain reaction were utilized to study the correlation between the expression of Thsd7a and clinical-pathological characteristics...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research