Correction: Gap junction-mediated transfer of miR-145-5p from microvascular endothelial cells to colon cancer cells inhibits angiogenesis
Oncotarget. 2024 May 7;15:285-287. doi: 10.18632/oncotarget.28528.NO ABSTRACTPMID:38712739 | PMC:PMC11075366 | DOI:10.18632/oncotarget.28528 (Source: Oncotarget)
Source: Oncotarget - May 7, 2024 Category: Cancer & Oncology Authors: Dominique Thuringer Gaetan Jego Kevin Berthenet Arlette Hammann Eric Solary Carmen Garrido Source Type: research

Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN
CONCLUSION: The Pix-2-Pix GAN model for generating AC-PET demonstrates SUV metrics that highly correlate with original images. AI-generated PET images show clinical potential for reducing the need for CT scans for attenuation correction while preserving quantitative markers and image quality.PMID:38712741 | PMC:PMC11075367 | DOI:10.18632/oncotarget.28583 (Source: Oncotarget)
Source: Oncotarget - May 7, 2024 Category: Cancer & Oncology Authors: Kevin C Ma Esther Mena Liza Lindenberg Nathan S Lay Phillip Eclarinal Deborah E Citrin Peter A Pinto Bradford J Wood William L Dahut James L Gulley Ravi A Madan Peter L Choyke Ismail Baris Turkbey Stephanie A Harmon Source Type: research

Correction: Gap junction-mediated transfer of miR-145-5p from microvascular endothelial cells to colon cancer cells inhibits angiogenesis
Oncotarget. 2024 May 7;15:285-287. doi: 10.18632/oncotarget.28528.NO ABSTRACTPMID:38712739 | PMC:PMC11075366 | DOI:10.18632/oncotarget.28528 (Source: Oncotarget)
Source: Oncotarget - May 7, 2024 Category: Cancer & Oncology Authors: Dominique Thuringer Gaetan Jego Kevin Berthenet Arlette Hammann Eric Solary Carmen Garrido Source Type: research

Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN
CONCLUSION: The Pix-2-Pix GAN model for generating AC-PET demonstrates SUV metrics that highly correlate with original images. AI-generated PET images show clinical potential for reducing the need for CT scans for attenuation correction while preserving quantitative markers and image quality.PMID:38712741 | PMC:PMC11075367 | DOI:10.18632/oncotarget.28583 (Source: Oncotarget)
Source: Oncotarget - May 7, 2024 Category: Cancer & Oncology Authors: Kevin C Ma Esther Mena Liza Lindenberg Nathan S Lay Phillip Eclarinal Deborah E Citrin Peter A Pinto Bradford J Wood William L Dahut James L Gulley Ravi A Madan Peter L Choyke Ismail Baris Turkbey Stephanie A Harmon Source Type: research

Correction: Gap junction-mediated transfer of miR-145-5p from microvascular endothelial cells to colon cancer cells inhibits angiogenesis
Oncotarget. 2024 May 7;15:285-287. doi: 10.18632/oncotarget.28528.NO ABSTRACTPMID:38712739 | PMC:PMC11075366 | DOI:10.18632/oncotarget.28528 (Source: Oncotarget)
Source: Oncotarget - May 7, 2024 Category: Cancer & Oncology Authors: Dominique Thuringer Gaetan Jego Kevin Berthenet Arlette Hammann Eric Solary Carmen Garrido Source Type: research

Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN
CONCLUSION: The Pix-2-Pix GAN model for generating AC-PET demonstrates SUV metrics that highly correlate with original images. AI-generated PET images show clinical potential for reducing the need for CT scans for attenuation correction while preserving quantitative markers and image quality.PMID:38712741 | PMC:PMC11075367 | DOI:10.18632/oncotarget.28583 (Source: Oncotarget)
Source: Oncotarget - May 7, 2024 Category: Cancer & Oncology Authors: Kevin C Ma Esther Mena Liza Lindenberg Nathan S Lay Phillip Eclarinal Deborah E Citrin Peter A Pinto Bradford J Wood William L Dahut James L Gulley Ravi A Madan Peter L Choyke Ismail Baris Turkbey Stephanie A Harmon Source Type: research

Correction: Gap junction-mediated transfer of miR-145-5p from microvascular endothelial cells to colon cancer cells inhibits angiogenesis
Oncotarget. 2024 May 7;15:285-287. doi: 10.18632/oncotarget.28528.NO ABSTRACTPMID:38712739 | PMC:PMC11075366 | DOI:10.18632/oncotarget.28528 (Source: Oncotarget)
Source: Oncotarget - May 7, 2024 Category: Cancer & Oncology Authors: Dominique Thuringer Gaetan Jego Kevin Berthenet Arlette Hammann Eric Solary Carmen Garrido Source Type: research

Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN
CONCLUSION: The Pix-2-Pix GAN model for generating AC-PET demonstrates SUV metrics that highly correlate with original images. AI-generated PET images show clinical potential for reducing the need for CT scans for attenuation correction while preserving quantitative markers and image quality.PMID:38712741 | PMC:PMC11075367 | DOI:10.18632/oncotarget.28583 (Source: Oncotarget)
Source: Oncotarget - May 7, 2024 Category: Cancer & Oncology Authors: Kevin C Ma Esther Mena Liza Lindenberg Nathan S Lay Phillip Eclarinal Deborah E Citrin Peter A Pinto Bradford J Wood William L Dahut James L Gulley Ravi A Madan Peter L Choyke Ismail Baris Turkbey Stephanie A Harmon Source Type: research

Correction: Gap junction-mediated transfer of miR-145-5p from microvascular endothelial cells to colon cancer cells inhibits angiogenesis
Oncotarget. 2024 May 7;15:285-287. doi: 10.18632/oncotarget.28528.NO ABSTRACTPMID:38712739 | DOI:10.18632/oncotarget.28528 (Source: Oncotarget)
Source: Oncotarget - May 7, 2024 Category: Cancer & Oncology Authors: Dominique Thuringer Gaetan Jego Kevin Berthenet Arlette Hammann Eric Solary Carmen Garrido Source Type: research

Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN
CONCLUSION: The Pix-2-Pix GAN model for generating AC-PET demonstrates SUV metrics that highly correlate with original images. AI-generated PET images show clinical potential for reducing the need for CT scans for attenuation correction while preserving quantitative markers and image quality.PMID:38712741 | DOI:10.18632/oncotarget.28583 (Source: Oncotarget)
Source: Oncotarget - May 7, 2024 Category: Cancer & Oncology Authors: Kevin C Ma Esther Mena Liza Lindenberg Nathan S Lay Phillip Eclarinal Deborah E Citrin Peter A Pinto Bradford J Wood William L Dahut James L Gulley Ravi A Madan Peter L Choyke Ismail Baris Turkbey Stephanie A Harmon Source Type: research

Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure
We examined the interaction between SARS-CoV-2 spike, p53 and MDM2 (E3 ligase, which mediates p53 degradation) in cancer cells using an immunoprecipitation assay. We observed that SARS-CoV-2 spike protein interrupts p53-MDM2 protein interaction but did not detect SARS-CoV-2 spike bound with p53 protein in the cancer cells. We further observed that SARS-CoV-2 spike suppresses p53 transcriptional activity in cancer cells including after nutlin exposure of wild-type p53-, spike-expressing tumor cells and inhibits chemotherapy-induced p53 gene activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2. The suppressive effect o...
Source: Oncotarget - May 6, 2024 Category: Cancer & Oncology Authors: Shengliang Zhang Wafik S El-Deiry Source Type: research

Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure
We examined the interaction between SARS-CoV-2 spike, p53 and MDM2 (E3 ligase, which mediates p53 degradation) in cancer cells using an immunoprecipitation assay. We observed that SARS-CoV-2 spike protein interrupts p53-MDM2 protein interaction but did not detect SARS-CoV-2 spike bound with p53 protein in the cancer cells. We further observed that SARS-CoV-2 spike suppresses p53 transcriptional activity in cancer cells including after nutlin exposure of wild-type p53-, spike-expressing tumor cells and inhibits chemotherapy-induced p53 gene activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2. The suppressive effect o...
Source: Oncotarget - May 6, 2024 Category: Cancer & Oncology Authors: Shengliang Zhang Wafik S El-Deiry Source Type: research

Exploring the role of GHRH antagonist MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia
Oncotarget. 2024 Apr 8;15:248-254. doi: 10.18632/oncotarget.28579.ABSTRACTAcute myeloid leukemia (AML) is characterized by the rapid proliferation of mutagenic hematopoietic progenitors in the bone marrow. Conventional therapies include chemotherapy and bone marrow stem cell transplantation; however, they are often associated with poor prognosis. Notably, growth hormone-releasing hormone (GHRH) receptor antagonist MIA-602 has been shown to impede the growth of various human cancer cell lines, including AML. This investigation examined the impact of MIA-602 as monotherapy and in combination with Doxorubicin on three Doxorub...
Source: Oncotarget - April 8, 2024 Category: Cancer & Oncology Authors: Simonetta I Gaumond Rama Abdin Joel Costoya Andrew V Schally Joaquin J Jimenez Source Type: research