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Total 964 results found since Jan 2013.
The effect of silencing the Tip60 gene on the response to radiotherapy in breast cancer cells
In this study, for the first time, the role of the silenced and active Tip60 gene in response to radiotherapy in MDA-MB-231 and MCF-7 cells was investigated. For this purpose, the Tip60 gene was silenced by applying siRNA to the cell lines and UV was applied. In the study, cytotoxicity and DNA breaks were measured by MTT and COMET methods, and mRNA and protein expression values were measured by PCR and Raman spectrophotometer in silenced, unsilenced, UV-treated, and non-UV-treated cell lines. According to the results of the study, increased DNA damage was observed in MCF-7 cell lines in which the Tip60 gene was silenced, a...
Source: Breast - April 17, 2023 Category: Cancer & Oncology Authors: Ece Miser-Saliho ğlu Bensu Karahalil Meri ç Arda Eşmakaya U ğur Tamer Sevgi Yardim-Akaydin Source Type: research
Runx2 overexpression promotes bone repair of osteonecrosis of the femoral head (ONFH)
CONCLUSIONS: Overexpression of Runx2 can improve osteoblastic phenotype maintenance of MSCs and promote necrotic bone repair of ONFH.PMID:37029290 | DOI:10.1007/s11033-023-08411-7
Source: Molecular Biology Reports - April 7, 2023 Category: Molecular Biology Authors: Hai-Jia Xu Xiang-Zhong Liu Lu Yang Yu Ning Liang-Liang Xu Da-Ming Sun Wen Liao Yi Yang Zhang-Hua Li Source Type: research
Cancers, Vol. 15, Pages 2005: CDK4/6 Inhibition Induces Senescence and Enhances Radiation Response by Disabling DNA Damage Repair in Oral Cavity Squamous Cell Carcinoma
Conclusion: Targeting CDK4/6 can lead to improved efficacy when combined with radiation in OCSCC by inducing senescence and inhibiting DNA damage repair.
Source: Cancers - March 28, 2023 Category: Cancer & Oncology Authors: Nitisha Shrivastava Claudia Gutierrez Chavez Daniel Li Vikas Mehta Carlos Thomas Cory D. Fulcher Nicole Kawachi Danielle M. Bottalico Michael B. Prystowsky Indranil Basu Chandan Guha Thomas J. Ow Tags: Article Source Type: research
APTX acts in DNA double-strand break repair in a manner distinct from XRCC4
J Radiat Res. 2023 Mar 20:rrad007. doi: 10.1093/jrr/rrad007. Online ahead of print.ABSTRACTAprataxin (APTX), the product of the causative gene for hereditary neurogenerative syndromes Ataxia-oculomotor apraxia 1 and early onset ataxia with oculomotor apraxia and hypoalbuminemia, has an enzymatic activity of removing adenosine monophosphate from DNA 5'-end, which arises from abortive ligation by DNA ligases. It is also reported that APTX physically binds to XRCC1 and XRCC4, suggesting its involvement in DNA single-strand break repair (SSBR) and DNA double-strand break repair (DSBR) via non-homologous end joining pathway. Al...
Source: Cell Research - March 20, 2023 Category: Cytology Authors: Rikiya Imamura Mizuki Saito Mikio Shimada Junya Kobayashi Masamichi Ishiai Yoshihisa Matsumoto Source Type: research
Radiosensitivity in Non-Small-Cell Lung Cancer by MMP10 through the DNA Damage Repair Pathway
This study investigated the function and associated mechanism of MMP10 during radiotherapy of NSCLC. MMP10 expression in patients and their overall survival rate were assessed through GEPIA. Protein expression was tested by western blotting. Radioresistance was detected in vitro by apoptosis and clonogenic assay. The extent of DNA damage and repair was revealed by the comet test and γH2AX foci test. High MMP10 levels in specimens of lung adenocarcinoma were related to poor patient outcomes. Clonogenic and apoptosis assays revealed that MMP10 knockdown in A549 cells initiated radiosensitization. Furthermore, MMP10 siRNA in...
Source: Journal of Oncology - March 13, 2023 Category: Cancer & Oncology Authors: Yawei Bi Kun Cao Yuan Wang Wei Yang Na Ma Xiao Lei Yuanyuan Chen Source Type: research
Regulation of XPC Binding Dynamics and Global Nucleotide Excision Repair by p63 and Vitamin D Receptor
J Phys Chem B. 2023 Mar 6. doi: 10.1021/acs.jpcb.2c07257. Online ahead of print.ABSTRACTp63 and the vitamin D receptor (VDR) play important roles in epidermal development and differentiation, but their roles and relationship in the response to ultraviolet (UV) radiation are less clear. Using TERT-immortalized human keratinocytes expressing shRNA targeting p63 in concert with exogenously applied siRNA targeting VDR, we assessed p63 and VDR's separate and combined effect on nucleotide excision repair (NER) of UV-induced 6-4 photoproducts (6-4PP). Knockdown of p63 reduced VDR and XPC expression relative to nontargeting contro...
Source: Health Physics - March 6, 2023 Category: Physics Authors: Christian T Wong Katherine Ona Dennis H Oh Source Type: research
Suppression of GCH1 Sensitizes Ovarian Cancer and Breast Cancer to PARP Inhibitor
CONCLUSION: Our results illustrated that PARP inhibitors promote GCH1 expression via the JAK-STAT pathway. We also elucidated the potential relationship between GCH1 and the homologous recombination repair pathway and proposed a combination regimen of GCH1 suppression with PARP inhibitors in breast and ovarian cancers.PMID:36793373 | PMC:PMC9925261 | DOI:10.1155/2023/1453739
Source: Journal of Oncology - February 16, 2023 Category: Cancer & Oncology Authors: Siyuan Wang Yu Xia Pu Huang Cheng Xu Yiyu Qian Tian Fang Qinglei Gao Source Type: research
Engineered NF- κB siRNA-encapsulating exosomes as a modality for therapy of skin lesions
DiscussionOverall, this study establishes a feasible therapeutic strategy for skin injury, which may offer an alternative to conventional biological therapies requiring two or more independent compounds.
Source: Frontiers in Immunology - February 8, 2023 Category: Allergy & Immunology Source Type: research
