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Procedure: Gastroschisis Repair
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Total 964 results found since Jan 2013.
Using computational methods to design patient-specific electrospun cardiac patches for pediatric heart failure
Biomaterials. 2022 Feb 18;283:121421. doi: 10.1016/j.biomaterials.2022.121421. Online ahead of print.ABSTRACTAutologous cardiac cell therapy is a promising treatment for combating the right ventricular heart failure (RVHF) that can occur in patients with congenital heart disease (CHD). However, autologous cell therapies suffer from low cell retention following injection and patient-to-patient variability in cell quality. Here, we demonstrate how computational methods can be used to identify mechanisms of cardiac-derived c-Kit+ cell (CPC) reparative capacity and how biomaterials can be designed to improve cardiac patch perf...
Source: Biomaterials - February 26, 2022 Category: Materials Science Authors: Benjamin W Streeter Milton E Brown Preety Shakya Hyun-Ji Park Jichuan Qiu Younan Xia Michael E Davis Source Type: research
Overexpression of c-Jun inhibits erastin-induced ferroptosis in Schwann cells and promotes repair of facial nerve function
In conclusion, our study identified the relationship between c-Jun and ferroptosis during peripheral nerve injury repair, which provides new ideas for studying peripheral nerve injury and repair.PMID:35191156 | DOI:10.1111/jcmm.17241
Source: Molecular Medicine - February 22, 2022 Category: Molecular Biology Authors: Dekun Gao Yuyu Huang Xiayu Sun Jun Yang Jianyong Chen Jingchun He Source Type: research
Depletion of RIPK4 parallels higher malignancy potential in cutaneous squamous cell carcinoma
CONCLUSIONS: In general, although depletion of RIPK4 cannot reverse the radiation resistance of A431 cells in vitro, it parallels higher malignancy potential in cutaneous SCC. To our knowledge, this is the first report of the effects of RIPK4 expression on the Raf/MEK/ERK signaling pathway and radiosensitivity in cutaneous SCC. The better understanding of the molecular mechanism of RIPK4 in cutaneous SCC may provide a promising biomarker for skin SCC prognosis and treatment.PMID:35186499 | PMC:PMC8841032 | DOI:10.7717/peerj.12932
Source: Cancer Control - February 21, 2022 Category: Cancer & Oncology Authors: Jing Xu Dongping Wu Bicheng Zhang Chi Pan Yinglu Guo Qichun Wei Source Type: research
Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity
Oncotarget. 2022 Feb 14;13:332-346. doi: 10.18632/oncotarget.28195. eCollection 2022.ABSTRACTThe functional status of the tumor suppressor p53 is a critical component in determining the sensitivity of cancer cells to many chemotherapeutic agents. DNA topoisomerase II (Top2) plays essential roles in DNA metabolism and is the target of FDA approved chemotherapeutic agents. Topoisomerase targeting drugs convert the enzyme into a DNA damaging agent and p53 influences cellular responses to these agents. We assessed the impact of the loss of p53 function on the formation of DNA damage induced by the Top2 poison etoposide. Using ...
Source: Oncotarget - February 18, 2022 Category: Cancer & Oncology Authors: Daniel Menendez Jay R Anand Carri C Murphy Whitney J Bell Jiaqi Fu Nadia Slepushkina Eugen Buehler Scott E Martin Madhu Lal-Nag John L Nitiss Michael A Resnick Source Type: research
HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer
CONCLUSIONS: Our results give a clear molecular mechanism at the basis of HPV regulation of the DDR pathway. In particular, we show how HPV stabilizes SMAD4 to promote DDR protein expression, which may be used to facilitate viral replication and HNC onset. Moreover, we found that SMAD4 silencing in HPV-positive HNC cell lines increases sensitivity to cisplatin treatment, suggesting that HPV-positive HNC with low SMAD4 expression may be preferentially susceptible to similar treatments.PMID:35144669 | DOI:10.1186/s13046-022-02258-9
Source: Cell Research - February 11, 2022 Category: Cytology Authors: Simona Citro Claudia Miccolo Alessandro Medda Lavinia Ghiani Marta Tagliabue Mohssen Ansarin Susanna Chiocca Source Type: research
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
Cell Stem Cell. 2022 Jan 24:S1934-5909(22)00001-7. doi: 10.1016/j.stem.2022.01.001. Online ahead of print.ABSTRACTIdentifying new pathways that regulate mammalian regeneration is challenging due to the paucity of in vivo screening approaches. We employed pooled CRISPR knockout and activation screening in the regenerating liver to evaluate 165 chromatin regulatory proteins. Both screens identified the imitation-SWI chromatin remodeling components Baz2a and Baz2b, not previously implicated in regeneration. In vivo sgRNA, siRNA, and knockout strategies against either paralog confirmed increased regeneration. Distinct BAZ2-spe...
Source: Cell Stem Cell - January 29, 2022 Category: Stem Cells Authors: Yuemeng Jia Lin Li Yu-Hsuan Lin Purva Gopal Shunli Shen Kejin Zhou Xueliang Yu Tripti Sharma Yu Zhang Daniel J Siegwart Joseph M Ready Hao Zhu Source Type: research
