Depletion of RIPK4 parallels higher malignancy potential in cutaneous squamous cell carcinoma

CONCLUSIONS: In general, although depletion of RIPK4 cannot reverse the radiation resistance of A431 cells in vitro, it parallels higher malignancy potential in cutaneous SCC. To our knowledge, this is the first report of the effects of RIPK4 expression on the Raf/MEK/ERK signaling pathway and radiosensitivity in cutaneous SCC. The better understanding of the molecular mechanism of RIPK4 in cutaneous SCC may provide a promising biomarker for skin SCC prognosis and treatment.PMID:35186499 | PMC:PMC8841032 | DOI:10.7717/peerj.12932
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research