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Condition: Hypertension

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Total 587 results found since Jan 2013.

Potential Role of Cartilage Oligomeric Matrix Protein in the Modulation of Pulmonary Arterial Smooth Muscle Superoxide by Hypoxia.
Abstract Changes in reactive oxygen species and extracellular matrix seem to participate in pulmonary hypertension development. Since we recently reported evidence for chronic hypoxia decreasing expression of cartilage oligomeric matrix protein (COMP) and evidence for this controlling loss of pulmonary arterial smooth muscle BMP receptor-2 (BMPR2) and contractile phenotype proteins, we examined if changes in superoxide metabolism could be an important factor in a bovine pulmonary artery (BPA), organoid cultured under hypoxia for 48hrs model. Hypoxia (3% oxygen) caused a depletion of COMP in BPA, but not in bovine ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - August 6, 2019 Category: Cytology Authors: Yu H, Alruwaili N, Hu B, Kelly MR, Zhang B, Sun D, Wolin MS Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

MicroRNA-214-3p Regulates Hypoxia-Mediated Pulmonary Artery Smooth Muscle Cell Proliferation and Migration by Targeting ARHGEF12.
CONCLUSIONS In conclusion, these results indicate that miR-214-3p acts as a novel regulator of hypoxia-induced proliferation and migration by directly targeting ARHGEF12 and dysregulating c-jun and c-fos in PASMCs, and may be a potential therapeutic target for treating pulmonary hypertension. PMID: 31373336 [PubMed - in process]
Source: Medical Science Monitor - August 3, 2019 Category: Research Tags: Med Sci Monit Source Type: research

PKC-delta mediates mineralocorticoid receptor activation by angiotensin II to modulate smooth muscle cell function.
Abstract Angiotensin II (AngII) and the mineralocorticoid receptor(MR) ligand aldosterone, both contribute to cardiovascular disorders, including hypertension and adverse vascular remodeling.We previously demonstrated that AngII activates MR-mediated gene transcription in human vascular smooth muscle cells(SMC) yet the mechanism and the impact on SMC function are unknown.Using a MR responsive element-driven transcriptional reporter assay, we confirm that AngII induces MR transcriptional activity in multiple vascular SMC and endothelial cells, but not in Cos1 nor HEK293 cells.AngII activation of MR was blocked by t...
Source: Endocrinology - August 1, 2019 Category: Endocrinology Authors: Lu Q, Davel AP, McGraw AP, Rao SP, Newfell BG, Jaffe IZ Tags: Endocrinology Source Type: research

MAL protein stabilizes luminal membrane PLC β3 and negatively regulates ENaC in mouse cortical collecting duct cells.
MAL protein stabilizes luminal membrane PLCβ3 and negatively regulates ENaC in mouse cortical collecting duct cells. Am J Physiol Renal Physiol. 2019 Jul 31;: Authors: Tuna KM, Liu BC, Yue Q, Ghazi ZM, Ma HP, Eaton DC, Alli AA Abstract Abnormally high epithelial sodium channel (ENaC) activity in the aldosterone sensitive distal nephron and collecting duct leads to hypertension. Mal is a lipid-raft-associated protein that has been previously shown to regulate NKCC2 (Na-K -2Cl co-transporter) and aquaporin-2 in the kidney, but it is not known whether it regulates renal ENaC. ENaC activity is positively...
Source: Am J Physiol Renal P... - July 30, 2019 Category: Urology & Nephrology Authors: Tuna KM, Liu BC, Yue Q, Ghazi ZM, Ma HP, Eaton DC, Alli AA Tags: Am J Physiol Renal Physiol Source Type: research

Down-regulation of lncRNA MALAT1 alleviates vascular lesion and vascular remodeling of rats with hypertension.
CONCLUSION: This study revealed that down-regulated lncRNA MALAT1 could alleviate the vascular lesion and remodeling of HTN rats, the mechanism may be related to the inhibited activation of Notch signaling pathway. PMID: 31343412 [PubMed - as supplied by publisher]
Source: Aging - July 24, 2019 Category: Biomedical Science Authors: Xue YZ, Li ZJ, Liu WT, Shan JJ, Wang L, Su Q Tags: Aging (Albany NY) Source Type: research

Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF- β1/Smads signaling pathways in spontaneous hypertension rats.
CONCLUSION: AA attenuates pressure overload-induced cardiac fibrosis via enhancing of Nrf2/HO-1 and suppressing TGF-β1/Smads phosphorylation. PMID: 31254954 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - June 25, 2019 Category: Allergy & Immunology Authors: Meng Z, Li HY, Si CY, Liu YZ, Teng S Tags: Int Immunopharmacol Source Type: research

Coordination between NADPH oxidase and vascular peroxidase 1 promotes dysfunctions of endothelial progenitor cells in hypoxia-induced pulmonary hypertensive rats.
This study aims to evaluate the correlation between NOX/VPO1 pathway and endothelial progenitor cells (EPCs) dysfunctions in hypoxia-induced pulmonary hypertension (PH). The rats were exposed to 10% hypoxia for 3 weeks to establish a PH model, which showed increases in right ventricle systolic pressure, right ventricular and pulmonary vascular remodeling, acceleration in apoptosis and impairment in functions of the peripheral blood derived - EPCs (the reduced abilities in adhesion, migration and tube formation), accompanied by up-regulation of NOX (NOX2 and NOX4) and VPO1. Next, normal EPCs were cultured under hypoxia to i...
Source: European Journal of Pharmacology - June 15, 2019 Category: Drugs & Pharmacology Authors: Wang EL, Jia MM, Luo FM, Li T, Peng JJ, Luo XJ, Song FL, Yang JF, Peng J, Liu B Tags: Eur J Pharmacol Source Type: research

Histone deacetylase 6 inhibitor tubastatin A attenuates angiotensin II-induced hypertension by preventing cystathionine γ-lyase protein degradation
Publication date: Available online 21 May 2019Source: Pharmacological ResearchAuthor(s): Zhexi Chi, Hye-Eun Byeon, Eunjeong Seo, Quynh-Anh T. Nguyen, Wonbeom Lee, Yunyong Jeong, Juyong Choi, Deepesh Pandey, Dan E. Berkowitz, Jae Hyung Kim, Sang Yoon LeeAbstractCystathionine γ-lyase (CSEγ) is a hydrogen sulfide (H2S)-producing enzyme. Endothelial H2S production can mediate vasodilatory effects, contributing to the alleviation of hypertension (high blood pressure). Recent studies have suggested a role of histone deacetylase 6 (HDAC6) in hypertension, although its underlying mechanisms are poorly understood. Here, we addres...
Source: Pharmacological Research - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

Increasing Upstream Chromatin Long –Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells
We examined the sponging potential of all significantly changed circRNAs using the CircInteractome database (Montefiori et al., 2018), recording two miRNAs with four or more predicted binding sites in a single circRNA transcript, a threshold above which meaningful sponging activity is likely to occur Memczak et al. (2013). Another four significantly changed circRNAs are experimentally shown to sponge miRNAs (Dudekula et al., 2016; Chen et al., 2017; Yan et al., 2017; Wang et al., 2018), for six total circRNAs with miRNA sponging activity including miR125, miR143, miR1272, miR153, miR515-5p, and miR196a-5p (Table 4). In Fig...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research

Immune-Modulation by the Human Respiratory Syncytial Virus: Focus on Dendritic Cells
This study is complemented by another report that found that hRSV infection induces significant expression of three miRNAs, namely hsa-miR-4448, hsa-miR-30a-5p, and hsa-miR-4634 in human DCs (104). Interestingly, this latter study also performed comparative analyses of miRNA profiles between DCs infected with hRSV and a related virus, namely the human metapneumovirus, and found that both viruses induced the expression of elevated levels of hsa-miR-4634. Elucidating the contribution of these miRNAs in DCs in response to hRSV remains to be determined. Dendritic Cell Phenotype and Migration Upon hRSV Infection in vivo Altho...
Source: Frontiers in Immunology - April 14, 2019 Category: Allergy & Immunology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Loss of reticulocalbin 2 lowers blood pressure and restrains angiotensin II-induced hypertension in vivo.
Abstract Hypertension affects over one billion people worldwide and increases risk for heart failure, stroke and chronic kidney disease. Despite high prevalence and devastating impact, its etiology still remains poorly understood for most hypertensive cases. Rcn2, encoding reticulocalbin 2, is a candidate gene for atherosclerosis we previously demonstrated in mice. Here we identified Rcn2 as a novel regulator of blood pressure in mice. Rcn2 was dramatically upregulated in arteries undergoing structural remodeling. Deletion of Rcn2 lowered basal blood pressure and attenuated angiotensin II-induced hypertension in C...
Source: Am J Physiol Renal P... - April 2, 2019 Category: Urology & Nephrology Authors: Li J, Cechova S, Wang L, Isakson BE, Le T, Shi W Tags: Am J Physiol Renal Physiol Source Type: research

LncRNA MRAK048635_P1 is critical for vascular smooth muscle cell function and phenotypic switching in essential hypertension.
In conclusion, our findings reveal that decreased MRAK048635_P1 is probably an important factor for vascular remodeling by affecting VSMC cell function and phenotypic switching in essential hypertension. PMID: 30833363 [PubMed - as supplied by publisher]
Source: Bioscience Reports - March 3, 2019 Category: Biomedical Science Authors: Fang G, Qi J, Huang L, Zhao X Tags: Biosci Rep Source Type: research

EPHA4 regulates vascular smooth muscle cell contractility and is a sex-specific hypertension risk gene in individuals with type 2 diabetes
Conclusion: EPHA4 appears to be a sex-specific hypertension risk gene in type 2 diabetic patients. Forward EPHA4 signalling reduces VSMC contractility, and estrogen is a modifier of this effect. The effect of EPHA4 on VSMCs contractility explains the association of EPHA4 gene with hypertension risks in female patients.
Source: Journal of Hypertension - March 1, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Heart and vessels Source Type: research

Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration
Publication date: April 2019Source: Redox Biology, Volume 22Author(s): Daniel S. de Jesus, Evan DeVallance, Yao Li, Micol Falabella, Danielle Guimaraes, Sruti Shiva, Brett A. Kaufman, Mark T. Gladwin, Patrick J. PaganoAbstractPulmonary arterial hypertension (PAH) is a complex degenerative disorder marked by aberrant vascular remodeling associated with hyperproliferation and migration of endothelial cells (ECs). Previous reports implicated bone morphogenetic protein antagonist Gremlin 1 in this process; however, little is known of the molecular mechanisms involved. The current study was designed to test whether redox signal...
Source: Redox Biology - February 23, 2019 Category: Biology Source Type: research