Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elucidate the efficacy and safety of plant-derived alkaloids and their correlation with in-built cellular and molecular mechanisms are needed to promote plant-derived alkaloids as IBD remedies in the near future. Author Contributions JP, T-TZ, Y-CH, and H-TX did a literature review and prepared the first draft of the manuscript. Y-CH, XL, YL, and L-JW edited the manuscript and proposed and included some vital modifications. Y-CH, H-TX, and L-JW designed the work and wrote the final edition of the manuscript. Funding This study was funded by the National Natural Science Foundation of China (Project Nos. 81560676 and 81660479); China Postdoctoral Science Foundation (Project No. 2018M640807), Health and Family Planning Commission of Shenzhen Municipality (Project No. SZSM201512026), Natural Science Foundation of Guangdong Province, China (Project No. 2018A0303...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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CONCLUSION: The results of our study may offer useful evidence for future development of female-specific prevention and public health intervention programs in aboriginal communities to reduce the burden of ACO. PMID: 31106621 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
CONCLUSIONS: Anti-IL-17a treatment was associated with a nearly 3-fold higher risk of IBD in CID patients. Treatment decisions for patients with CIDs should take into account the risk of developing of IBD. PMID: 31106607 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Authors: Scicchitano P, Cortese F, Gesualdo M, De Palo M, Massari F, Giordano P, Ciccone MM Abstract Cerebrovascular diseases (CBD) are one of the most dangerous complications of atherosclerosis. The clinical consequences of CBD deeply impact quality of life and the prognosis of patients. Atherosclerosis is the main cause of CBD development. Hypertension, dyslipidemia, diabetes, smoking, obesity, and other risk factors explain the higher CBD incidence in the general population, as they are able to anticipate the clinical expression of atherosclerosis. These risk factors are effectively able to promote endothelial d...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Authors: Marinho PM, Salomon TB, Andrade AS, Behling CS, Putti JS, Benfato MS, Schäfer Hackenhaar F Abstract Menopause occurs as consequence of ovarian senescence that leads to a drop of oestrogen hormone. The decreased oestrogen levels combined with the impairment of the redox system may contribute to the increased risk of postmenopausal cardiovascular disease. Supplementation with antioxidants may be an alternative to reduce cardiovascular risk. The study evaluated the effect of dietary supplementation with docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and alpha-lipoic acid (LA) for a period of 16&...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Authors: Kong D, Ding Y, Liu J, Liu R, Zhang J, Zhou Q, Long Z, Peng J, Li L, Bai H, Hai C Abstract Paraquat (PQ) is a widely used agro-chemical in agriculture and highly toxic to humans. Although the mechanism of PQ poisoning is not clear, it has been well documented that reactive oxygen species (ROS) generation and apoptosis play pivotal roles. Alternatively, chlorogenic acid (CA) is a biologically active dietary polyphenol, playing several therapeutic roles. However, it is not known whether CA has protective effect on PQ-induced apoptosis. Here, we investigated the effect of CA in preventing PQ-induced apoptosis...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Hearthside Food Solutions of Woodridge, IL is voluntarily recalling 7-Eleven ‘The Italian Job’ sandwiches, which have an incorrect information panel label that does not declare eggs as an allergen. Persons who have an allergy or severe sensitivity to eggs run the risk of serious or life-threatening
Source: FDA Food Alergies - Category: Food Science Authors: Source Type: alerts
Ottogi America, Inc. of Gardena, California announced today it is recalling 1lb 5.16ounce of Jin Ramen Mild 5pk. (Best Before Aug. 19th 2019) and Jin Ramen Spicy 5pk. (Best Before Aug. 20th 2019) due to undeclared egg as an ingredient on the packages
Source: FDA Food Alergies - Category: Food Science Authors: Source Type: alerts
Kwik Trip, Inc. located in La Crosse, WI is recalling Kitchen Cravings Strawberry and Mixed Berry Parfaits in an 8.25 oz. cup because they may contain undeclared traces of cashews or almonds
Source: FDA Food Alergies - Category: Food Science Authors: Source Type: alerts
Chukar Cherries of Prosser, WA expands a recall on Ultra Dark Chocolate product because it may contain undeclared milk. People who have an allergy or severe sensitivity to milk run the risk of serious or life-threatening allergic reaction if they consume these products.
Source: FDA Food Alergies - Category: Food Science Authors: Source Type: alerts
Art Cream of Orwigsburg, PA is recalling 40 units of Gluten Free Cookies N Cream, because it may contain undeclared Pecans. People who have an allergy or severe sensitivity to specific type of allergen (e.g., peanuts, tree nuts {chestnuts, brazil nuts, walnuts, hazelnuts, pecans, pine nuts, cashews}
Source: FDA Food Alergies - Category: Food Science Authors: Source Type: alerts
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