Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elucidate the efficacy and safety of plant-derived alkaloids and their correlation with in-built cellular and molecular mechanisms are needed to promote plant-derived alkaloids as IBD remedies in the near future. Author Contributions JP, T-TZ, Y-CH, and H-TX did a literature review and prepared the first draft of the manuscript. Y-CH, XL, YL, and L-JW edited the manuscript and proposed and included some vital modifications. Y-CH, H-TX, and L-JW designed the work and wrote the final edition of the manuscript. Funding This study was funded by the National Natural Science Foundation of China (Project Nos. 81560676 and 81660479); China Postdoctoral Science Foundation (Project No. 2018M640807), Health and Family Planning Commission of Shenzhen Municipality (Project No. SZSM201512026), Natural Science Foundation of Guangdong Province, China (Project No. 2018A0303...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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AbstractData regarding COVID-19 vaccine efficacy and adverse events  (AE) in patients with autoimmune and inflammatory rheumatic diseases (AIIRD) have been published recently although these mostly include the mRNA vaccines (Pfizer-BioNTech and Moderna) and the ChAdOx1 nCoV-19/AZD1222 (Oxford-AstraZeneca). This research aimed to study the prevalence of AE presented with six different SARS-CoV-2 vaccines {ChadOX1 nCoV-19 (AZD1222), Ad5-nCoV2, Ad26.COV2.S, mRNA-1273, BNT162b2, and CoronaVac} in Mexican patients with AIIRD. We performed a cross-sectional study about vaccine history. Two hundred and twenty five consecutive...
Source: Rheumatology International - Category: Rheumatology Source Type: research
We describe a patient with psoriasis, psoriatic arthritis and uveitis who was treated with adalimum ab and after 4 months of the treatment developed clinical and neuroradiological signs of demyelinating disease of the central nervous system. She experienced no signs and symptoms of neurological disease prior to adalimumab administration. After a detailed neurological work-up she was diagnosed wit h relapsing–remitting type of multiple sclerosis and treated with oral and pulse glucocorticoids and later with dimethyl fumarate. Adalimumab was discontinued. The question remains was the demyelination induced by the T...
Source: Rheumatology International - Category: Rheumatology Source Type: research
The objectives of this study were to determine the levels of CRF and PA in people who have CVD-RA and to investigate the association of CRF with PA in people who have CVD-RA. A total of 24 consecutive patients (19 women) with CVD-RA (>  4% for 10-year risk of fatal CVD development as calculated using the Systematic Coronary Risk Evaluation)—were included in the study. CRF was assessed with a graded maximal exercise test determining maximal oxygen uptake (VO2max). PA was assessed with an accelerometer to determine the amount of step count, sedentary, light and moderate-to-vigorous physical activity (MVPA) mi...
Source: Rheumatology International - Category: Rheumatology Source Type: research
This study aimed to detect patients ’ characteristics who suffered severe and critical COVID-19 pneumonia admitted to the post-acute COVID-19 rehabilitation clinic in Ankara City Hospital, Physical Medicine and Rehabilitation Hospital and to share our experiences and outcomes of rehabilitation programmes applied. This study was desi gned as a single-centre, retrospective, observational study. Severe and critical COVID-19 patients, admitted to the post-acute COVID-19 rehabilitation clinic, were included in patient-based rehabilitation programmes, targeting neuromuscular and respiratory recovery. Functional status, oxy...
Source: Rheumatology International - Category: Rheumatology Source Type: research
AbstractSystemic lupus erythematosus (SLE) is a multifactorial autoimmune disease and polymorphisms in the cytokine genes and their receptors are thought to influence its development. The aim of this case –control study was to investigate the association of theIL-17A rs2275913,IL-17RC rs708567 andTGFB1 rs1800469 polymorphisms with SLE, its clinical manifestations and the polymorphisms influence on the IL-17A serum levels. Altogether 59 SLE patients with lupus nephritis and 95 healthy controls were genotyped by TaqMan assay. Serum levels were determined by Human IL-17A Platinum ELISA kit. From the studied polymorphism...
Source: Rheumatology International - Category: Rheumatology Source Type: research
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Source: Rheumatology International - Category: Rheumatology Source Type: research
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Source: Rheumatology International - Category: Rheumatology Source Type: research
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Source: Rheumatology International - Category: Rheumatology Source Type: research
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Source: Rheumatology International - Category: Rheumatology Source Type: research
ConclusionIncidence of tuberculosis in SLE is higher than general population and is associated with different phenotype and higher mortality. Male gender was associated with increased risk of tuberculosis in SLE.
Source: Rheumatology International - Category: Rheumatology Source Type: research
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