Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elucidate the efficacy and safety of plant-derived alkaloids and their correlation with in-built cellular and molecular mechanisms are needed to promote plant-derived alkaloids as IBD remedies in the near future. Author Contributions JP, T-TZ, Y-CH, and H-TX did a literature review and prepared the first draft of the manuscript. Y-CH, XL, YL, and L-JW edited the manuscript and proposed and included some vital modifications. Y-CH, H-TX, and L-JW designed the work and wrote the final edition of the manuscript. Funding This study was funded by the National Natural Science Foundation of China (Project Nos. 81560676 and 81660479); China Postdoctoral Science Foundation (Project No. 2018M640807), Health and Family Planning Commission of Shenzhen Municipality (Project No. SZSM201512026), Natural Science Foundation of Guangdong Province, China (Project No. 2018A0303...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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