Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elucidate the efficacy and safety of plant-derived alkaloids and their correlation with in-built cellular and molecular mechanisms are needed to promote plant-derived alkaloids as IBD remedies in the near future. Author Contributions JP, T-TZ, Y-CH, and H-TX did a literature review and prepared the first draft of the manuscript. Y-CH, XL, YL, and L-JW edited the manuscript and proposed and included some vital modifications. Y-CH, H-TX, and L-JW designed the work and wrote the final edition of the manuscript. Funding This study was funded by the National Natural Science Foundation of China (Project Nos. 81560676 and 81660479); China Postdoctoral Science Foundation (Project No. 2018M640807), Health and Family Planning Commission of Shenzhen Municipality (Project No. SZSM201512026), Natural Science Foundation of Guangdong Province, China (Project No. 2018A0303...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
ABSTRACTX ‐linked hypophosphatemia (XLH) is characterized by increased activity of circulating FGF23 resulting in renal phosphate wasting and abnormal bone mineralization. Hyperparathyroidism may develop in XLH patients; however its prevalence, pathogenesis and clinical presentation are not documented.This observational study (CNIL 2171036 v 0) recruited XLH adult patients in a single tertiary referral center. Each patient was explored in standardized conditions and compared with two healthy volunteers, matched for sex, age and 25 ‐OH vitamin D concentrations. The primary endpoint was the proportion of patients with hy...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
In conclusion, our findings provide d the direct evidences and the crucial role of NPY in cartilage homeostasis.This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
In conclusion, implementation of FLS was associated with a reduced risk of recurrent fracture, indicating that FLSs should be included routinely at hospitals treating fracture patients.This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
ABSTRACTThe loss of estrogen (E2) initiates a rapid phase of bone loss leading to osteoporosis in one ‐half of postmenopausal women, but the mechanism is not fully understood. Here, we show for the first time how loss of E2 activates low ‐grade inflammation to promote the acute phase of bone catabolic activity in ovariectomized (OVX) mice. E2 regulates the abundance of dendritic cells (DCs) that express IL ‐7 and IL‐15 by inducing the Fas ligand (FasL) and apoptosis of the DC. In the absence of E2, DCs become long ‐lived, leading to increased IL‐7 and IL‐15. We find that IL‐7 and IL‐15 together, but not a...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
Authors: Xu H, Dong L, Bin Z, Yansong H, Shaofeng L, Chang L, Chen C, Changli W Abstract Despite the excellent efficacy and low toxicity of photoresponse therapy, which has attracted considerable attention for use in non-small cell lung cancer (NSCLC) therapy, unsatisfactory cellular permeability, and instability, both in vitro and in vivo have limited further clinical applications of indole cyanine photosensitizers. Here, we explore the supramolecular self-assembly of a 'hyalurosome' that is mediated by calcium phosphate nanonuclei. Through hyaluronate-mediated CD44 targeting, the constructed hyalurosome...
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Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
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Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
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Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
Despite the increasing morbidity and mortality of the opioid epidemic, the rates of pain medication use among the urogynecology patient population is not known. Our objective was to describe the baseline prevalence of preoperative opioid and neuropathic pain medication use in patients presenting for urogynecologic surgery and to determine whether this rate changed before and after passage of anti-opioid state legislation.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
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