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Total 587 results found since Jan 2013.

Petits ARN interf érents : applications potentielles pour les néphrologues Small interfering RNA: potential applications for nephrologists
Nephrol Ther. 2022 Dec;18(6S1):6S1-6S6. doi: 10.1016/S1769-7255(22)00646-0.ABSTRACTSmall interfering RNA (siRNAs) are double-stranded RNAs of around 20 base pairs in length that trigger RNAi machinery, which promotes degradation of a target mRNA avoiding protein translation. SiRNAs are liver-targeted, using tris N-acetylgalactosamine (GalNAc) as the targeting ligand. This discovery received the Nobel Prize for medicine and physiology in 2006 and lead to substantial therapeutic advances. Application field and development of these siRNA has been very fast. Indeed, patisiran has been released in 2018 for hereditary transthyre...
Source: Nephrologie and Therapeutique - December 30, 2022 Category: Urology & Nephrology Authors: Sandrine Lemoine Marie Courbebaisse Source Type: research

IL-11 increases levels and activates circulating fibrocytes in different pulmonary hypertension animal models.
In conclusion, IL-11 promotes an increase of circulating fibrocytes, their adhesion to HPAECs and phenotypic switching to myofibroblast.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Roger, I., Milara, J., Montero, P., Belhadj, N., Cortijo, J. Tags: 13.01 - Pulmonary hypertension Source Type: research

COX2 expression is downregulated in a shear stress magnitude-dependent manner in BMPR2-silenced HPAECs: implications for prostacyclin deficiency in PAH
Conclusion: BMPR2 loss may disrupt the flow-driven production of COX2 in HPAECs, which may be an underlying mechanism of endothelial dysfunction in PAH.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Mahomed, A., Burke-Gaffney, A., Ghazaly, M., Naser, J., Toe, Q., Quinlan, G., Wort, S. J. Tags: 13.01 - Pulmonary hypertension Source Type: research