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Condition: Hypertension

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Total 587 results found since Jan 2013.

GRK2 expression and catalytic activity are essential for vasoconstrictor / ERK-stimulated arterial smooth muscle proliferation
Biochem Pharmacol. 2023 Sep 8:115795. doi: 10.1016/j.bcp.2023.115795. Online ahead of print.ABSTRACTProlonged vasoconstrictor signalling found in hypertension, increases arterial contraction, and alters vessel architecture by stimulating arterial smooth muscle cell (ASMC) growth, underpinning the development of re-stenosis lesions and vascular remodelling. Vasoconstrictors interact with their cognate G protein coupled receptors activating a variety of signalling pathways to promote smooth muscle proliferation. Here, angiotensin II (AngII) and endothelin 1 (ET1), but not UTP stimulates ASMC proliferation. Moreover, siRNA-me...
Source: Biochemical Pharmacology - September 10, 2023 Category: Drugs & Pharmacology Authors: Asma Alonazi Craig A Nash Chuan-Han Wang Elena Christofidou R A John Challiss Jonathon M Willets Source Type: research

Positive Topline Results for Antihypertensive Zilebesiran Positive Topline Results for Antihypertensive Zilebesiran
The investigational siRNA therapeutic showed consistent and sustained reductions in systolic blood pressure in a phase 2 study of adults with hypertension.Medscape Medical News
Source: Medscape Cardiology Headlines - September 8, 2023 Category: Cardiology Tags: Cardiology News Source Type: news

Effect of GRK4 on renal gastrin receptor regulation in hypertension
CONCLUSION: GRK4 participates in the development of hypertension by regulating the phosphorylation of renal CCKBR leading to impaired CCKBR function and water and sodium retention. Knockdown of GRK4 restored the function of CCKBR. The enhanced co-connection between GRK4 and CCKBR may be an important reason for the hyperphosphorylation of GRK4 and CCKBR involved in the pathogenesis of hypertension.PMID:37641972 | DOI:10.1080/10641963.2023.2245580
Source: Clinical and Experimental Hypertension - August 29, 2023 Category: Cardiology Authors: Xuewei Xia Yongchun Zeng Zhuxin Li Hao Luo Wei Wang Yanji He Bingjun Lu Jingwen Guo Ken Chen Xiang Xu Source Type: research

Ferrostatin-1 Blunts Right Ventricular Hypertrophy and Dysfunction in Pulmonary Arterial Hypertension by Suppressing the HMOX1/GSH Signaling
AbstractFerroptosis plays a critical role in pulmonary arterial hypertension (PAH)-induced right ventricular (RV) dysfunction, but key genes remain largely unclear. We here identified HMOX1 as an essential ferroptosis-related differentially expressed gene in PAH by bioinformatic analysis using FerrDb, GSE119754, and GSE3675 datasets, respectively. Notably, there were marked increases in HMOX1 and iron levels in RV of monocrotaline-induced PAH rats with reduced TAPSE levels. More importantly, treatment with ferrostatin-1 effectively attenuated RV hypertrophy, remodeling, myocardial fibrosis, and dysfunction in PAH rats. In ...
Source: Journal of Cardiovascular Translational Research - August 21, 2023 Category: Cardiology Source Type: research

miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding
In conclusion, miR-145 alleviates phenotype transition from contractile to synthetic type via ADAM17-mediated ACE2 shedding in VSMCs and retains the activation of ACE2-Ang-(1-7)-Mas axis, which may benefit the vascular structural remodeling in the metabolic hypertension.PMID:37521117 | PMC:PMC10374374 | DOI:10.1155/2023/9497716
Source: International Journal of Hypertension - July 31, 2023 Category: Cardiology Authors: Juan Wen Baiyi Tang Lan Guo Wei Chen Xiaohong Tang Source Type: research