Left ventricular long-axis ultrasound strain (GLS) is an ideal indicator for patients with anti-hypertension treatment
Clin Exp Hypertens. 2021 Sep 15:1-6. doi: 10.1080/10641963.2021.1969663. Online ahead of print.ABSTRACTBACKGROUND: Primary hypertension is one of the most well-known risk factors for cardiovascular disease. Currently, there is still no ideal indicator for left ventricular end-diastolic pressure.METHODS: 73 hypertension patients and 37 healthy people were enrolled in this study. Each member was examined with conventional echocardiography including multiple indicators such as Peak mitral valve flow velocity (E, A), E/A, left atrial volume index (LAVl), tissue Doppler (PW-TDI) peak velocities during early and late diastolic m...
Source: Clinical and Experimental Hypertension - September 15, 2021 Category: Cardiology Authors: Tingting Wu Lulu Zheng Saidan Zhang Lan Duan Jing Ma Lihuang Zha Lingfang Li Source Type: research

Left ventricular long-axis ultrasound strain (GLS) is an ideal indicator for patients with anti-hypertension treatment
Clin Exp Hypertens. 2021 Sep 15:1-6. doi: 10.1080/10641963.2021.1969663. Online ahead of print.ABSTRACTBACKGROUND: Primary hypertension is one of the most well-known risk factors for cardiovascular disease. Currently, there is still no ideal indicator for left ventricular end-diastolic pressure.METHODS: 73 hypertension patients and 37 healthy people were enrolled in this study. Each member was examined with conventional echocardiography including multiple indicators such as Peak mitral valve flow velocity (E, A), E/A, left atrial volume index (LAVl), tissue Doppler (PW-TDI) peak velocities during early and late diastolic m...
Source: Clinical and Experimental Hypertension - September 15, 2021 Category: Cardiology Authors: Tingting Wu Lulu Zheng Saidan Zhang Lan Duan Jing Ma Lihuang Zha Lingfang Li Source Type: research

Left ventricular long-axis ultrasound strain (GLS) is an ideal indicator for patients with anti-hypertension treatment
Clin Exp Hypertens. 2021 Sep 15:1-6. doi: 10.1080/10641963.2021.1969663. Online ahead of print.ABSTRACTBACKGROUND: Primary hypertension is one of the most well-known risk factors for cardiovascular disease. Currently, there is still no ideal indicator for left ventricular end-diastolic pressure.METHODS: 73 hypertension patients and 37 healthy people were enrolled in this study. Each member was examined with conventional echocardiography including multiple indicators such as Peak mitral valve flow velocity (E, A), E/A, left atrial volume index (LAVl), tissue Doppler (PW-TDI) peak velocities during early and late diastolic m...
Source: Clinical and Experimental Hypertension - September 15, 2021 Category: Cardiology Authors: Tingting Wu Lulu Zheng Saidan Zhang Lan Duan Jing Ma Lihuang Zha Lingfang Li Source Type: research

Left ventricular long-axis ultrasound strain (GLS) is an ideal indicator for patients with anti-hypertension treatment
Clin Exp Hypertens. 2021 Sep 15:1-6. doi: 10.1080/10641963.2021.1969663. Online ahead of print.ABSTRACTBACKGROUND: Primary hypertension is one of the most well-known risk factors for cardiovascular disease. Currently, there is still no ideal indicator for left ventricular end-diastolic pressure.METHODS: 73 hypertension patients and 37 healthy people were enrolled in this study. Each member was examined with conventional echocardiography including multiple indicators such as Peak mitral valve flow velocity (E, A), E/A, left atrial volume index (LAVl), tissue Doppler (PW-TDI) peak velocities during early and late diastolic m...
Source: Clinical and Experimental Hypertension - September 15, 2021 Category: Cardiology Authors: Tingting Wu Lulu Zheng Saidan Zhang Lan Duan Jing Ma Lihuang Zha Lingfang Li Source Type: research

Left ventricular long-axis ultrasound strain (GLS) is an ideal indicator for patients with anti-hypertension treatment
Clin Exp Hypertens. 2021 Sep 15:1-6. doi: 10.1080/10641963.2021.1969663. Online ahead of print.ABSTRACTBACKGROUND: Primary hypertension is one of the most well-known risk factors for cardiovascular disease. Currently, there is still no ideal indicator for left ventricular end-diastolic pressure.METHODS: 73 hypertension patients and 37 healthy people were enrolled in this study. Each member was examined with conventional echocardiography including multiple indicators such as Peak mitral valve flow velocity (E, A), E/A, left atrial volume index (LAVl), tissue Doppler (PW-TDI) peak velocities during early and late diastolic m...
Source: Clinical and Experimental Hypertension - September 15, 2021 Category: Cardiology Authors: Tingting Wu Lulu Zheng Saidan Zhang Lan Duan Jing Ma Lihuang Zha Lingfang Li Source Type: research

Gym and home-based combined training in men with primary hypertension: are they equally effective on functional fitness profile, body composition components, and biochemical parameters of hypertension?
CONCLUSION: These results suggest that in hypertensive men, HBCTr equally to GBCTr improved functional fitness and body composition remarkably without necessarily reducing resting blood pressure. Therefore, they can be advisable substitutes for gaining health benefits.PMID:34467787 | DOI:10.1080/10641963.2021.1960365 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - September 1, 2021 Category: Cardiology Authors: Fatemeh Islami Marziyeh Saghebjoo Toba Kazemi Mehdi Hedayati Source Type: research

Gym and home-based combined training in men with primary hypertension: are they equally effective on functional fitness profile, body composition components, and biochemical parameters of hypertension?
CONCLUSION: These results suggest that in hypertensive men, HBCTr equally to GBCTr improved functional fitness and body composition remarkably without necessarily reducing resting blood pressure. Therefore, they can be advisable substitutes for gaining health benefits.PMID:34467787 | DOI:10.1080/10641963.2021.1960365 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - September 1, 2021 Category: Cardiology Authors: Fatemeh Islami Marziyeh Saghebjoo Toba Kazemi Mehdi Hedayati Source Type: research

Gym and home-based combined training in men with primary hypertension: are they equally effective on functional fitness profile, body composition components, and biochemical parameters of hypertension?
CONCLUSION: These results suggest that in hypertensive men, HBCTr equally to GBCTr improved functional fitness and body composition remarkably without necessarily reducing resting blood pressure. Therefore, they can be advisable substitutes for gaining health benefits.PMID:34467787 | DOI:10.1080/10641963.2021.1960365 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - September 1, 2021 Category: Cardiology Authors: Fatemeh Islami Marziyeh Saghebjoo Toba Kazemi Mehdi Hedayati Source Type: research

Gym and home-based combined training in men with primary hypertension: are they equally effective on functional fitness profile, body composition components, and biochemical parameters of hypertension?
CONCLUSION: These results suggest that in hypertensive men, HBCTr equally to GBCTr improved functional fitness and body composition remarkably without necessarily reducing resting blood pressure. Therefore, they can be advisable substitutes for gaining health benefits.PMID:34467787 | DOI:10.1080/10641963.2021.1960365 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - September 1, 2021 Category: Cardiology Authors: Fatemeh Islami Marziyeh Saghebjoo Toba Kazemi Mehdi Hedayati Source Type: research

Gym and home-based combined training in men with primary hypertension: are they equally effective on functional fitness profile, body composition components, and biochemical parameters of hypertension?
CONCLUSION: These results suggest that in hypertensive men, HBCTr equally to GBCTr improved functional fitness and body composition remarkably without necessarily reducing resting blood pressure. Therefore, they can be advisable substitutes for gaining health benefits.PMID:34467787 | DOI:10.1080/10641963.2021.1960365 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - September 1, 2021 Category: Cardiology Authors: Fatemeh Islami Marziyeh Saghebjoo Toba Kazemi Mehdi Hedayati Source Type: research

Gym and home-based combined training in men with primary hypertension: are they equally effective on functional fitness profile, body composition components, and biochemical parameters of hypertension?
CONCLUSION: These results suggest that in hypertensive men, HBCTr equally to GBCTr improved functional fitness and body composition remarkably without necessarily reducing resting blood pressure. Therefore, they can be advisable substitutes for gaining health benefits.PMID:34467787 | DOI:10.1080/10641963.2021.1960365 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - September 1, 2021 Category: Cardiology Authors: Fatemeh Islami Marziyeh Saghebjoo Toba Kazemi Mehdi Hedayati Source Type: research

Metabolic syndrome and its components predict the development of arterial stiffening in a sample of adult men
Clin Exp Hypertens. 2021 Aug 29:1-8. doi: 10.1080/10641963.2021.1969664. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVE: Metabolic syndrome (MS) and its components are associated with greater cardiovascular risk. A number of studies found a positive association between MS and vascular damage, but few observational studies evaluated the predictive role of MS on arterial stiffening (AS). Therefore, the aim of this study was to estimate the ability of MS and its components to predict the risk of AS in an 8-year follow-up of a sample of adult men (Olivetti Heart Study).METHODS: The analysis included 778 men without AS ...
Source: Clinical and Experimental Hypertension - August 30, 2021 Category: Cardiology Authors: Lanfranco D'Elia Antonio Barbato Roberto Iacone Ornella Russo Pasquale Strazzullo Ferruccio Galletti Source Type: research

Metabolic syndrome and its components predict the development of arterial stiffening in a sample of adult men
Clin Exp Hypertens. 2021 Aug 29:1-8. doi: 10.1080/10641963.2021.1969664. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVE: Metabolic syndrome (MS) and its components are associated with greater cardiovascular risk. A number of studies found a positive association between MS and vascular damage, but few observational studies evaluated the predictive role of MS on arterial stiffening (AS). Therefore, the aim of this study was to estimate the ability of MS and its components to predict the risk of AS in an 8-year follow-up of a sample of adult men (Olivetti Heart Study).METHODS: The analysis included 778 men without AS ...
Source: Clinical and Experimental Hypertension - August 30, 2021 Category: Cardiology Authors: Lanfranco D'Elia Antonio Barbato Roberto Iacone Ornella Russo Pasquale Strazzullo Ferruccio Galletti Source Type: research

Association of Chlamydophila pneumoniae infection and hypertension during pregnancy - A case control study
CONCLUSION: There is a significant association between C. pneumoniae infection and hypertension during pregnancy and further studies are required to fulfil the Koch's postulates to prove or disprove it as a causative agent.PMID:34433341 | DOI:10.1080/10641963.2021.1969661 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 26, 2021 Category: Cardiology Authors: Bhagyashree Gundagurti Papa Dasari Rakesh Singh Source Type: research

Association of Chlamydophila pneumoniae infection and hypertension during pregnancy - A case control study
CONCLUSION: There is a significant association between C. pneumoniae infection and hypertension during pregnancy and further studies are required to fulfil the Koch's postulates to prove or disprove it as a causative agent.PMID:34433341 | DOI:10.1080/10641963.2021.1969661 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 26, 2021 Category: Cardiology Authors: Bhagyashree Gundagurti Papa Dasari Rakesh Singh Source Type: research

Study on the relationship between < em > SLCO1B1 < /em > and < em > ApoE < /em > gene polymorphisms and the risk of coronary heart disease in the Mongolian population
This study aimed to analyze the influence of SLCO1B1 and APOE gene polymorphisms on coronary heart disease in Mongolian population who living in Ordos area. Methods From January 2019 to June 2020, 200 Mongolian patients with coronary heart disease admitted to our hospital and other banner hospitals were selected as the case group. At the same time, 150 randomly selected healthy Mongolian people from medical examination centers comprised the control group. The polymorphisms of SLCO1B1 (388A>G, 521 T> C) and ApoE (388 T> C, 526 C> t) were detected by real-time polymerase chain reaction. Combined with environmenta...
Source: Clinical and Experimental Hypertension - August 23, 2021 Category: Cardiology Authors: Rui-Bing Niu Xiao-Xian Dong Li-Ping Guo Li Pan Yue-Qin Hai Xiao-Xiao Chen Bao-Sheng Duan Source Type: research

Uric acid-lowering effect of dotinurad, a novel selective urate reabsorption inhibitor, in hypertensive patients with gout or asymptomatic hyperuricemia: a pooled analysis of individual participant data in phase II and III trials
Conclusions: In the pooled analysis, dotinurad lowered serum uric acid levels. Dotinurad has an achievement rate of over 80% for serum uric acid level of ≤6.0 mg/dL in both analyses, and will be clinically useful for the management of hyperuricemic states in hypertensive patients.PMID:34425059 | DOI:10.1080/10641963.2021.1950752 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 23, 2021 Category: Cardiology Authors: Toshinari Takahashi Takanobu Beppu Yuji Hidaka Tatsuo Hosoya Source Type: research

Study on the relationship between < em > SLCO1B1 < /em > and < em > ApoE < /em > gene polymorphisms and the risk of coronary heart disease in the Mongolian population
This study aimed to analyze the influence of SLCO1B1 and APOE gene polymorphisms on coronary heart disease in Mongolian population who living in Ordos area. Methods From January 2019 to June 2020, 200 Mongolian patients with coronary heart disease admitted to our hospital and other banner hospitals were selected as the case group. At the same time, 150 randomly selected healthy Mongolian people from medical examination centers comprised the control group. The polymorphisms of SLCO1B1 (388A>G, 521 T> C) and ApoE (388 T> C, 526 C> t) were detected by real-time polymerase chain reaction. Combined with environmenta...
Source: Clinical and Experimental Hypertension - August 23, 2021 Category: Cardiology Authors: Rui-Bing Niu Xiao-Xian Dong Li-Ping Guo Li Pan Yue-Qin Hai Xiao-Xiao Chen Bao-Sheng Duan Source Type: research

Uric acid-lowering effect of dotinurad, a novel selective urate reabsorption inhibitor, in hypertensive patients with gout or asymptomatic hyperuricemia: a pooled analysis of individual participant data in phase II and III trials
Conclusions: In the pooled analysis, dotinurad lowered serum uric acid levels. Dotinurad has an achievement rate of over 80% for serum uric acid level of ≤6.0 mg/dL in both analyses, and will be clinically useful for the management of hyperuricemic states in hypertensive patients.PMID:34425059 | DOI:10.1080/10641963.2021.1950752 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 23, 2021 Category: Cardiology Authors: Toshinari Takahashi Takanobu Beppu Yuji Hidaka Tatsuo Hosoya Source Type: research

Study on the relationship between < em > SLCO1B1 < /em > and < em > ApoE < /em > gene polymorphisms and the risk of coronary heart disease in the Mongolian population
This study aimed to analyze the influence of SLCO1B1 and APOE gene polymorphisms on coronary heart disease in Mongolian population who living in Ordos area. Methods From January 2019 to June 2020, 200 Mongolian patients with coronary heart disease admitted to our hospital and other banner hospitals were selected as the case group. At the same time, 150 randomly selected healthy Mongolian people from medical examination centers comprised the control group. The polymorphisms of SLCO1B1 (388A>G, 521 T> C) and ApoE (388 T> C, 526 C> t) were detected by real-time polymerase chain reaction. Combined with environmenta...
Source: Clinical and Experimental Hypertension - August 23, 2021 Category: Cardiology Authors: Rui-Bing Niu Xiao-Xian Dong Li-Ping Guo Li Pan Yue-Qin Hai Xiao-Xiao Chen Bao-Sheng Duan Source Type: research

Uric acid-lowering effect of dotinurad, a novel selective urate reabsorption inhibitor, in hypertensive patients with gout or asymptomatic hyperuricemia: a pooled analysis of individual participant data in phase II and III trials
Conclusions: In the pooled analysis, dotinurad lowered serum uric acid levels. Dotinurad has an achievement rate of over 80% for serum uric acid level of ≤6.0 mg/dL in both analyses, and will be clinically useful for the management of hyperuricemic states in hypertensive patients.PMID:34425059 | DOI:10.1080/10641963.2021.1950752 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 23, 2021 Category: Cardiology Authors: Toshinari Takahashi Takanobu Beppu Yuji Hidaka Tatsuo Hosoya Source Type: research

Renin-angiotensin system modulators in COVID-19 patients with hypertension: friend or foe?
Conclusion: Current evidence reveals no increased risk of COVID-19 infection among hypertensive patients on ACEIs/ARBs compared to other antihypertensive medications. Several studies have demonstrated no detrimental effects of RAS modulators on clinical severity, hospital/intensive care unit stay, ventilation and mortality. Hence, we can conclude that neither ARBs nor ACEIs treatment will cause any side effects or undesirable interactions in COVID-19 infected hypertensive patients.PMID:34414841 | DOI:10.1080/10641963.2021.1963070 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 20, 2021 Category: Cardiology Authors: Shakhi Shylesh C M Arya V S Kanthlal S K Uma Devi P Source Type: research

Renin-angiotensin system modulators in COVID-19 patients with hypertension: friend or foe?
Conclusion: Current evidence reveals no increased risk of COVID-19 infection among hypertensive patients on ACEIs/ARBs compared to other antihypertensive medications. Several studies have demonstrated no detrimental effects of RAS modulators on clinical severity, hospital/intensive care unit stay, ventilation and mortality. Hence, we can conclude that neither ARBs nor ACEIs treatment will cause any side effects or undesirable interactions in COVID-19 infected hypertensive patients.PMID:34414841 | DOI:10.1080/10641963.2021.1963070 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 20, 2021 Category: Cardiology Authors: Shakhi Shylesh C M Arya V S Kanthlal S K Uma Devi P Source Type: research

Renin-angiotensin system modulators in COVID-19 patients with hypertension: friend or foe?
Conclusion: Current evidence reveals no increased risk of COVID-19 infection among hypertensive patients on ACEIs/ARBs compared to other antihypertensive medications. Several studies have demonstrated no detrimental effects of RAS modulators on clinical severity, hospital/intensive care unit stay, ventilation and mortality. Hence, we can conclude that neither ARBs nor ACEIs treatment will cause any side effects or undesirable interactions in COVID-19 infected hypertensive patients.PMID:34414841 | DOI:10.1080/10641963.2021.1963070 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 20, 2021 Category: Cardiology Authors: Shakhi Shylesh C M Arya V S Kanthlal S K Uma Devi P Source Type: research

The potential role of RAAS-related hsa_circ_0122153 and hsa_circ_0025088 in essential hypertension
Conclusion: Highly expressed hsa_circ_0122153 and hsa_circ_0025088 increase the risk of EH. The hsa_circ_0122153/hsa-miR-483-3p and hsa_circ_0025088/hsa-miR-27a-3p axis involving RAAS were potential EH pathways.PMID:34392742 | DOI:10.1080/10641963.2021.1945077 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 16, 2021 Category: Cardiology Authors: Xin He Zhenbo Tao Zebo Zhang Wenming He Yanqing Xie Lina Zhang Source Type: research

Insight into the cardiovascular mechanisms of blood pressure lowering effect of gitogenin: a steroidal saponin
Clin Exp Hypertens. 2021 Aug 15:1-7. doi: 10.1080/10641963.2021.1950748. Online ahead of print.ABSTRACTBackground/objectives: Steroidal saponins are widely distributed in medicinal plants with potential applications in cardiovascular disorders. Gitogenin, a saponin, has not been explored as antihypertensive; this investigation was aimed to explore its blood pressure lowering potential and underlying mechanisms.Methodology: The effect of gitogenin was evaluated on blood pressure in vivo, using normotensive rat model and the underlying cardiovascular mechanism(s) in vitro, in isolated rat aorta and in atria preparations usin...
Source: Clinical and Experimental Hypertension - August 16, 2021 Category: Cardiology Authors: Imran Ul Haq Taous Khan Taseer Ahmad Abdul Jabbar Shah Source Type: research

The potential role of RAAS-related hsa_circ_0122153 and hsa_circ_0025088 in essential hypertension
Conclusion: Highly expressed hsa_circ_0122153 and hsa_circ_0025088 increase the risk of EH. The hsa_circ_0122153/hsa-miR-483-3p and hsa_circ_0025088/hsa-miR-27a-3p axis involving RAAS were potential EH pathways.PMID:34392742 | DOI:10.1080/10641963.2021.1945077 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 16, 2021 Category: Cardiology Authors: Xin He Zhenbo Tao Zebo Zhang Wenming He Yanqing Xie Lina Zhang Source Type: research

Insight into the cardiovascular mechanisms of blood pressure lowering effect of gitogenin: a steroidal saponin
Clin Exp Hypertens. 2021 Aug 15:1-7. doi: 10.1080/10641963.2021.1950748. Online ahead of print.ABSTRACTBackground/objectives: Steroidal saponins are widely distributed in medicinal plants with potential applications in cardiovascular disorders. Gitogenin, a saponin, has not been explored as antihypertensive; this investigation was aimed to explore its blood pressure lowering potential and underlying mechanisms.Methodology: The effect of gitogenin was evaluated on blood pressure in vivo, using normotensive rat model and the underlying cardiovascular mechanism(s) in vitro, in isolated rat aorta and in atria preparations usin...
Source: Clinical and Experimental Hypertension - August 16, 2021 Category: Cardiology Authors: Imran Ul Haq Taous Khan Taseer Ahmad Abdul Jabbar Shah Source Type: research

The potential role of RAAS-related hsa_circ_0122153 and hsa_circ_0025088 in essential hypertension
Conclusion: Highly expressed hsa_circ_0122153 and hsa_circ_0025088 increase the risk of EH. The hsa_circ_0122153/hsa-miR-483-3p and hsa_circ_0025088/hsa-miR-27a-3p axis involving RAAS were potential EH pathways.PMID:34392742 | DOI:10.1080/10641963.2021.1945077 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 16, 2021 Category: Cardiology Authors: Xin He Zhenbo Tao Zebo Zhang Wenming He Yanqing Xie Lina Zhang Source Type: research

Insight into the cardiovascular mechanisms of blood pressure lowering effect of gitogenin: a steroidal saponin
Clin Exp Hypertens. 2021 Aug 15:1-7. doi: 10.1080/10641963.2021.1950748. Online ahead of print.ABSTRACTBackground/objectives: Steroidal saponins are widely distributed in medicinal plants with potential applications in cardiovascular disorders. Gitogenin, a saponin, has not been explored as antihypertensive; this investigation was aimed to explore its blood pressure lowering potential and underlying mechanisms.Methodology: The effect of gitogenin was evaluated on blood pressure in vivo, using normotensive rat model and the underlying cardiovascular mechanism(s) in vitro, in isolated rat aorta and in atria preparations usin...
Source: Clinical and Experimental Hypertension - August 16, 2021 Category: Cardiology Authors: Imran Ul Haq Taous Khan Taseer Ahmad Abdul Jabbar Shah Source Type: research

The potential role of RAAS-related hsa_circ_0122153 and hsa_circ_0025088 in essential hypertension
Conclusion: Highly expressed hsa_circ_0122153 and hsa_circ_0025088 increase the risk of EH. The hsa_circ_0122153/hsa-miR-483-3p and hsa_circ_0025088/hsa-miR-27a-3p axis involving RAAS were potential EH pathways.PMID:34392742 | DOI:10.1080/10641963.2021.1945077 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 16, 2021 Category: Cardiology Authors: Xin He Zhenbo Tao Zebo Zhang Wenming He Yanqing Xie Lina Zhang Source Type: research

Insight into the cardiovascular mechanisms of blood pressure lowering effect of gitogenin: a steroidal saponin
Clin Exp Hypertens. 2021 Aug 15:1-7. doi: 10.1080/10641963.2021.1950748. Online ahead of print.ABSTRACTBackground/objectives: Steroidal saponins are widely distributed in medicinal plants with potential applications in cardiovascular disorders. Gitogenin, a saponin, has not been explored as antihypertensive; this investigation was aimed to explore its blood pressure lowering potential and underlying mechanisms.Methodology: The effect of gitogenin was evaluated on blood pressure in vivo, using normotensive rat model and the underlying cardiovascular mechanism(s) in vitro, in isolated rat aorta and in atria preparations usin...
Source: Clinical and Experimental Hypertension - August 16, 2021 Category: Cardiology Authors: Imran Ul Haq Taous Khan Taseer Ahmad Abdul Jabbar Shah Source Type: research

Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults
Clin Exp Hypertens. 2021 Aug 6:1-8. doi: 10.1080/10641963.2021.1960364. Online ahead of print.ABSTRACTOBJECTIVE: Despite the strong correlation between elevated alanine aminotransferase (ALT) and hypertension, their bi-directional and temporal relationship are currently unclear. Our study aimed to explore the bi-directional and temporal association between elevated ALT (ALT> 40 U/L) and hypertension.METHODS: Measurements of alanine aminotransferase and blood pressure were obtained twice from 2013 to 2017 in 3314 Chinese adults without cardiovascular disease at baseline. Bi-directional and cross-lagged panel analyses wer...
Source: Clinical and Experimental Hypertension - August 6, 2021 Category: Cardiology Authors: Guoxin Huang Hui Zhou Chao Shen Yihui Sheng Ruyu Xue Chen Dong Shaoyan Zhang Source Type: research

Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults
Clin Exp Hypertens. 2021 Aug 6:1-8. doi: 10.1080/10641963.2021.1960364. Online ahead of print.ABSTRACTOBJECTIVE: Despite the strong correlation between elevated alanine aminotransferase (ALT) and hypertension, their bi-directional and temporal relationship are currently unclear. Our study aimed to explore the bi-directional and temporal association between elevated ALT (ALT> 40 U/L) and hypertension.METHODS: Measurements of alanine aminotransferase and blood pressure were obtained twice from 2013 to 2017 in 3314 Chinese adults without cardiovascular disease at baseline. Bi-directional and cross-lagged panel analyses wer...
Source: Clinical and Experimental Hypertension - August 6, 2021 Category: Cardiology Authors: Guoxin Huang Hui Zhou Chao Shen Yihui Sheng Ruyu Xue Chen Dong Shaoyan Zhang Source Type: research

Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults
Clin Exp Hypertens. 2021 Aug 6:1-8. doi: 10.1080/10641963.2021.1960364. Online ahead of print.ABSTRACTOBJECTIVE: Despite the strong correlation between elevated alanine aminotransferase (ALT) and hypertension, their bi-directional and temporal relationship are currently unclear. Our study aimed to explore the bi-directional and temporal association between elevated ALT (ALT> 40 U/L) and hypertension.METHODS: Measurements of alanine aminotransferase and blood pressure were obtained twice from 2013 to 2017 in 3314 Chinese adults without cardiovascular disease at baseline. Bi-directional and cross-lagged panel analyses wer...
Source: Clinical and Experimental Hypertension - August 6, 2021 Category: Cardiology Authors: Guoxin Huang Hui Zhou Chao Shen Yihui Sheng Ruyu Xue Chen Dong Shaoyan Zhang Source Type: research

Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults
Clin Exp Hypertens. 2021 Aug 6:1-8. doi: 10.1080/10641963.2021.1960364. Online ahead of print.ABSTRACTOBJECTIVE: Despite the strong correlation between elevated alanine aminotransferase (ALT) and hypertension, their bi-directional and temporal relationship are currently unclear. Our study aimed to explore the bi-directional and temporal association between elevated ALT (ALT> 40 U/L) and hypertension.METHODS: Measurements of alanine aminotransferase and blood pressure were obtained twice from 2013 to 2017 in 3314 Chinese adults without cardiovascular disease at baseline. Bi-directional and cross-lagged panel analyses wer...
Source: Clinical and Experimental Hypertension - August 6, 2021 Category: Cardiology Authors: Guoxin Huang Hui Zhou Chao Shen Yihui Sheng Ruyu Xue Chen Dong Shaoyan Zhang Source Type: research

Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults
Clin Exp Hypertens. 2021 Aug 6:1-8. doi: 10.1080/10641963.2021.1960364. Online ahead of print.ABSTRACTOBJECTIVE: Despite the strong correlation between elevated alanine aminotransferase (ALT) and hypertension, their bi-directional and temporal relationship are currently unclear. Our study aimed to explore the bi-directional and temporal association between elevated ALT (ALT> 40 U/L) and hypertension.METHODS: Measurements of alanine aminotransferase and blood pressure were obtained twice from 2013 to 2017 in 3314 Chinese adults without cardiovascular disease at baseline. Bi-directional and cross-lagged panel analyses wer...
Source: Clinical and Experimental Hypertension - August 6, 2021 Category: Cardiology Authors: Guoxin Huang Hui Zhou Chao Shen Yihui Sheng Ruyu Xue Chen Dong Shaoyan Zhang Source Type: research

Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults
Clin Exp Hypertens. 2021 Aug 6:1-8. doi: 10.1080/10641963.2021.1960364. Online ahead of print.ABSTRACTOBJECTIVE: Despite the strong correlation between elevated alanine aminotransferase (ALT) and hypertension, their bi-directional and temporal relationship are currently unclear. Our study aimed to explore the bi-directional and temporal association between elevated ALT (ALT> 40 U/L) and hypertension.METHODS: Measurements of alanine aminotransferase and blood pressure were obtained twice from 2013 to 2017 in 3314 Chinese adults without cardiovascular disease at baseline. Bi-directional and cross-lagged panel analyses wer...
Source: Clinical and Experimental Hypertension - August 6, 2021 Category: Cardiology Authors: Guoxin Huang Hui Zhou Chao Shen Yihui Sheng Ruyu Xue Chen Dong Shaoyan Zhang Source Type: research

Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults
Clin Exp Hypertens. 2021 Aug 6:1-8. doi: 10.1080/10641963.2021.1960364. Online ahead of print.ABSTRACTOBJECTIVE: Despite the strong correlation between elevated alanine aminotransferase (ALT) and hypertension, their bi-directional and temporal relationship are currently unclear. Our study aimed to explore the bi-directional and temporal association between elevated ALT (ALT> 40 U/L) and hypertension.METHODS: Measurements of alanine aminotransferase and blood pressure were obtained twice from 2013 to 2017 in 3314 Chinese adults without cardiovascular disease at baseline. Bi-directional and cross-lagged panel analyses wer...
Source: Clinical and Experimental Hypertension - August 6, 2021 Category: Cardiology Authors: Guoxin Huang Hui Zhou Chao Shen Yihui Sheng Ruyu Xue Chen Dong Shaoyan Zhang Source Type: research

Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults
Clin Exp Hypertens. 2021 Aug 6:1-8. doi: 10.1080/10641963.2021.1960364. Online ahead of print.ABSTRACTOBJECTIVE: Despite the strong correlation between elevated alanine aminotransferase (ALT) and hypertension, their bi-directional and temporal relationship are currently unclear. Our study aimed to explore the bi-directional and temporal association between elevated ALT (ALT> 40 U/L) and hypertension.METHODS: Measurements of alanine aminotransferase and blood pressure were obtained twice from 2013 to 2017 in 3314 Chinese adults without cardiovascular disease at baseline. Bi-directional and cross-lagged panel analyses wer...
Source: Clinical and Experimental Hypertension - August 6, 2021 Category: Cardiology Authors: Guoxin Huang Hui Zhou Chao Shen Yihui Sheng Ruyu Xue Chen Dong Shaoyan Zhang Source Type: research

The association of aortic elasticity properties with novel inflammatory marker CRP /albumin ratio
Clin Exp Hypertens. 2021 Aug 2:1-8. doi: 10.1080/10641963.2021.1960368. Online ahead of print.ABSTRACTOBJECTIVE: Hypertension (HT) is the most important preventable cause of cardiovascular disease and mortality. Aortic elasticity parameters are affected in HT, and inflammation plays a central role in the development of HT. C-reactive protein (CRP) to albumin ratio (CAR) is a novel inflammatory marker. We aimed to evaluate the association of aortic elasticity properties with CAR.METHODS: A total of newly diagnosed untreated 101 hypertensive patients and 98 control participants were included to study. Clinical, demographic p...
Source: Clinical and Experimental Hypertension - August 3, 2021 Category: Cardiology Authors: Mustafa Karanfil Kadriye Gayretli Yayla Source Type: research

The association of aortic elasticity properties with novel inflammatory marker CRP /albumin ratio
Clin Exp Hypertens. 2021 Aug 2:1-8. doi: 10.1080/10641963.2021.1960368. Online ahead of print.ABSTRACTOBJECTIVE: Hypertension (HT) is the most important preventable cause of cardiovascular disease and mortality. Aortic elasticity parameters are affected in HT, and inflammation plays a central role in the development of HT. C-reactive protein (CRP) to albumin ratio (CAR) is a novel inflammatory marker. We aimed to evaluate the association of aortic elasticity properties with CAR.METHODS: A total of newly diagnosed untreated 101 hypertensive patients and 98 control participants were included to study. Clinical, demographic p...
Source: Clinical and Experimental Hypertension - August 3, 2021 Category: Cardiology Authors: Mustafa Karanfil Kadriye Gayretli Yayla Source Type: research

The association of aortic elasticity properties with novel inflammatory marker CRP /albumin ratio
Clin Exp Hypertens. 2021 Aug 2:1-8. doi: 10.1080/10641963.2021.1960368. Online ahead of print.ABSTRACTOBJECTIVE: Hypertension (HT) is the most important preventable cause of cardiovascular disease and mortality. Aortic elasticity parameters are affected in HT, and inflammation plays a central role in the development of HT. C-reactive protein (CRP) to albumin ratio (CAR) is a novel inflammatory marker. We aimed to evaluate the association of aortic elasticity properties with CAR.METHODS: A total of newly diagnosed untreated 101 hypertensive patients and 98 control participants were included to study. Clinical, demographic p...
Source: Clinical and Experimental Hypertension - August 3, 2021 Category: Cardiology Authors: Mustafa Karanfil Kadriye Gayretli Yayla Source Type: research

Can Systemic Immune-Inflammation Index Detect the Presence of Exxaggerated Morning Blood Pressure Surge in Newly Diagnosed Treatment-Naive Hypertensive Patients?
Clin Exp Hypertens. 2021 Aug 2:1-8. doi: 10.1080/10641963.2021.1960366. Online ahead of print.ABSTRACTBackground: The exaggerated morning blood pressure surge (MS) is associated with target organ damage and cardiovascular events. Systemic immune-inflammation index (SII) has been detected as a useful marker in tumors and cardiovascular diseases. The role of inflammation in the pathogenesis of hypertension is a well-known issue. We aimed to investigate whether there is an association between SII and exaggerated MS in newly diagnosed treatment-naive hypertensive patients.Material and Methods: In total, 343 newly diagnosed in ...
Source: Clinical and Experimental Hypertension - August 2, 2021 Category: Cardiology Authors: Faysal Saylik Remzi Sar ─▒kaya Source Type: research

Long-term amlodipine-based combination therapy attenuates seasonal variation of blood pressure in hypertensive patients
This study was to investigate whether long-term amlodipine-based combination therapy attenuates seasonal variation of office blood pressure (BP) in hypertensive patients. Methods: The data of 206 patients recruited in the Nanchang site of CHIEF trial were retrospectively analyzed. All patients received an amlodipine-based therapy for thres years after reaching target BP with a 12-week titration treatment. Among them, 106 patients received amlodipine plus amiloride/hydrochlorothiazide (AA group) and 100 received amlodipine plus telmisartan (AT group) therapies. These patients were followed up every three months . The differ...
Source: Clinical and Experimental Hypertension - August 2, 2021 Category: Cardiology Authors: Hua-Song Xia Yue Liu Ju-Xiang Li Hai Su Yan-Qing Wu Source Type: research

Can Systemic Immune-Inflammation Index Detect the Presence of Exxaggerated Morning Blood Pressure Surge in Newly Diagnosed Treatment-Naive Hypertensive Patients?
Clin Exp Hypertens. 2021 Aug 2:1-8. doi: 10.1080/10641963.2021.1960366. Online ahead of print.ABSTRACTBackground: The exaggerated morning blood pressure surge (MS) is associated with target organ damage and cardiovascular events. Systemic immune-inflammation index (SII) has been detected as a useful marker in tumors and cardiovascular diseases. The role of inflammation in the pathogenesis of hypertension is a well-known issue. We aimed to investigate whether there is an association between SII and exaggerated MS in newly diagnosed treatment-naive hypertensive patients.Material and Methods: In total, 343 newly diagnosed in ...
Source: Clinical and Experimental Hypertension - August 2, 2021 Category: Cardiology Authors: Faysal Saylik Remzi Sar ─▒kaya Source Type: research

Long-term amlodipine-based combination therapy attenuates seasonal variation of blood pressure in hypertensive patients
This study was to investigate whether long-term amlodipine-based combination therapy attenuates seasonal variation of office blood pressure (BP) in hypertensive patients. Methods: The data of 206 patients recruited in the Nanchang site of CHIEF trial were retrospectively analyzed. All patients received an amlodipine-based therapy for thres years after reaching target BP with a 12-week titration treatment. Among them, 106 patients received amlodipine plus amiloride/hydrochlorothiazide (AA group) and 100 received amlodipine plus telmisartan (AT group) therapies. These patients were followed up every three months . The differ...
Source: Clinical and Experimental Hypertension - August 2, 2021 Category: Cardiology Authors: Hua-Song Xia Yue Liu Ju-Xiang Li Hai Su Yan-Qing Wu Source Type: research

Aqueous extract of large cardamom inhibits vascular damage, oxidative stress, and metabolic changes in fructose-fed hypertensive rats
CONCLUSION: In summary, the obtained results suggest that AELC can prevent and reverse the high blood pressure induced by fructose, probably by restoring nitric oxide level and by improving altered metabolic parameters.PMID:34281445 | DOI:10.1080/10641963.2021.1925682 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - July 20, 2021 Category: Cardiology Authors: Kanthlal Sk Arya Vs Bindhu Paul-Prasanth Vijayakumar M Rema Shree Ab Uma Devi P Source Type: research

Aqueous extract of large cardamom inhibits vascular damage, oxidative stress, and metabolic changes in fructose-fed hypertensive rats
CONCLUSION: In summary, the obtained results suggest that AELC can prevent and reverse the high blood pressure induced by fructose, probably by restoring nitric oxide level and by improving altered metabolic parameters.PMID:34281445 | DOI:10.1080/10641963.2021.1925682 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - July 20, 2021 Category: Cardiology Authors: Kanthlal Sk Arya Vs Bindhu Paul-Prasanth Vijayakumar M Rema Shree Ab Uma Devi P Source Type: research

Aqueous extract of large cardamom inhibits vascular damage, oxidative stress, and metabolic changes in fructose-fed hypertensive rats
CONCLUSION: In summary, the obtained results suggest that AELC can prevent and reverse the high blood pressure induced by fructose, probably by restoring nitric oxide level and by improving altered metabolic parameters.PMID:34281445 | DOI:10.1080/10641963.2021.1925682 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - July 20, 2021 Category: Cardiology Authors: Kanthlal Sk Arya Vs Bindhu Paul-Prasanth Vijayakumar M Rema Shree Ab Uma Devi P Source Type: research