Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice.
This study aimed to investigate the effect of Nrf2 inhibition on oxidative stress-associated hypertension and renal dopamine 1 receptor (D1R) dysfunction in mice. Male C57BL/6 J mice were treated with a pro-oxidant, L-buthionine sulfoximine (BSO) (10 mmol/L in drinking water), and ML385 (10 kg body weight/kg body weight/day, intraperitoneally), a novel Nrf2 inhibitor that blocks Nrf2 regulated downstream target genes expression. Mice treated with BSO exhibited oxidative stress, renal functional impairment, inflammation, and elevated blood pressure. Also, BSO treatment increased the activity of phase II antioxidan...
Source: Clinical and Experimental Hypertension - October 18, 2020 Category: Cardiology Authors: Farooqui Z, Mohammad RS, Lokhandwala MF, Banday AA Tags: Clin Exp Hypertens Source Type: research

Renal sympathetic denervation attenuates left ventricle hypertrophy in spontaneously hypertensive rats by suppressing the Raf/MEK/ERK signaling pathway.
Abstract OBJECTIVE: To explore the effect of renal sympathetic denervation (RSD) on left ventricle hypertrophy and the Raf/MEK/ERK signaling pathway in spontaneously hypertensive rats (SHRs). METHODS: SHRs were divided into SHR, SHR + Sham, SHR + RSD and SHR + U0126 groups, with WKY rats as the baseline controls. The blood pressure of rats was observed, while myocardial fibrosis was evaluated through Masson staining. Thereafter, real-time quantitative polymerase chain reaction (qRT-PCR) was carried out to determine the levels of myocardial-hypertrophy-related markers, and Western blotting was used to measure ...
Source: Clinical and Experimental Hypertension - October 18, 2020 Category: Cardiology Authors: Xiao B, Liu F, Jin YH, Jin YQ, Wang L, Lu JC, Yang XC Tags: Clin Exp Hypertens Source Type: research

Vitamin A deficiency indicating as low expression of LRAT may be a novel biomarker of primary hypertension.
Abstract AIMS: Vitamin A (VA) deficiency triggers many diseases and is a worldwide nutrition problem. The Retinol acyltransferase (LRAT) is an indicator of VA storage function, and the relationship between LRAT and blood pressure level and the regulation mechanism will be elucidated. METHODS: 160 children aged 6-12 years were included, and the serum VA and, the transcription levels of LRAT and RARs, were measured. Spontaneously hypertensive rats (SHRs) and WKY rats were treated with VA deficiency (VAD) or normal (VAN) fodder for 20 weeks. LRAT, retinoic acid, renin angiotensin system (RAS) biomarker...
Source: Clinical and Experimental Hypertension - October 14, 2020 Category: Cardiology Authors: Liang X, Chen M, Wang D, Wen J, Chen J Tags: Clin Exp Hypertens Source Type: research

Twelve weeks of resistance training performed with different number of sets: Effects on maximal strength and resting blood pressure of individuals with hypertension.
This study aimed to verify the effect of resistance training performed with single (SET1) or three sets (SET3) on muscle strength and resting blood pressure (BP) of individuals with hypertension. BP was also assessed during knee extension exercise with submaximal load before and after training. Methods: Thirty-eight patients with hypertension were randomly assigned to a control group (CON: n = 12; 55.6 ± 3.2 years; 65.3 ± 9.3 kg; 163.5 ± 8.6 cm), SET1 group (n = 14; 58.1 ± 2.0 years; 65.4 ± 8.7 kg; 162.4 &plus...
Source: Clinical and Experimental Hypertension - October 10, 2020 Category: Cardiology Authors: Polito MD, Papst R, Goessler K Tags: Clin Exp Hypertens Source Type: research

Assessment of arterial stiffness and epicardial adipose tissue thickness in predicting the subclinical atherosclerosis in patients with ankylosing spondylitis.
Abstract OBJECTIVE: Atherosclerosis is a chronic, progressive, inflammatory disease. Recognition of subclinical atherosclerotic vascular changes before clinical manifestation in an asymptomatic population is important for risk stratification and optimal management, which finally leads to the prevention of cardiovascular disease. We aimed to determine the risk of premature subclinical atherosclerosis by evaluating epicardial adipose tissue thickness (EATT) and arterial stiffness parameters in patients with ankylosing spondylitis (AS). METHODS: We performed a prospective study of 60 consecutive patients meeting...
Source: Clinical and Experimental Hypertension - October 8, 2020 Category: Cardiology Authors: Demir K, Avcı A, Ergulu Esmen S, Tuncez A, Yalcın MU, Yılmaz A, Yılmaz S, Altunkeser BB Tags: Clin Exp Hypertens Source Type: research

Association between lipid profile and endothelial dysfunction as assessed by the reactive hyperemia index.
Abstract INTRODUCTION: We investigated the associations between endothelial dysfunction (ED) as evaluated by the reactive hyperemia index (RHI) obtained using Endo-PAT2000® and atherosclerotic risk factors in patients who underwent coronary artery angiography (CAG). METHODS: The subjects consisted of 191 patients who were clinically suspected to have CAD and underwent CAG, and in whom we could perform Endo-PAT2000®. We divided the patients into ED (RHI
Source: Clinical and Experimental Hypertension - September 30, 2020 Category: Cardiology Authors: Norimatsu K, Gondo K, Kusumoto T, Motozato K, Suematsu Y, Fukuda Y, Kuwano T, Miura SI Tags: Clin Exp Hypertens Source Type: research

The effect of swimming training on adrenomedullin levels, oxidative stress variables, and gastrocnemius muscle contractile properties in hypertensive rats.
Conclusion: In conclusion, 6-week exercise intervention rescued rats from high blood pressure, but did not have ameliorative effect on the decreased ADM levels. PMID: 32985250 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - September 26, 2020 Category: Cardiology Authors: Koc Yildirim E, Dedeoglu Z, Kaya M, Uner AG Tags: Clin Exp Hypertens Source Type: research

Is Masked Hypertension an underlying Cause of Unexplained Left Ventricle Hypertrophy?
Özkan S Abstract OBJECTIVES: Unexplained left ventricular hypertrophy (ULVH) is defined as increased wall thickness in the absence of conditions that predispose to hypertrophy. The aim of this study was to evaluate the rate of masked hypertension in patient with unexplained left ventricle hypertrophy. METHOD: A total of 120 consecutive unexplained left ventricle hypertrophy patients without overt hypertension and diabetes and 121 healthy control subjects were included in the study. After a complete medical history and laboratory examination, patients' height, weight, waist circumference heart rate, and ...
Source: Clinical and Experimental Hypertension - September 26, 2020 Category: Cardiology Authors: Yılmaz ÖÇ, Özkan S Tags: Clin Exp Hypertens Source Type: research

Exercise training ameliorates adrenergic control in spontaneously hypertensive rats.
Abstract The goal of this study was to examine vascular control after sympathetic stimulation by tyramine infusion in hypertensive rats submitted to swimming training. To this end, male rats were assigned to the following groups: sedentary (SN) and trained normotensive (TN), sedentary (SH) and trained hypertensive (TH). Arterial pressure (AP), heart rate (HR), HR variability (HRV), AP variability (APV), and cardiac autonomic function were recorded. Following, infusion of tyramine was administrated. The TN and TH showed a lower resting HR compared with their respective sedentary groups (p
Source: Clinical and Experimental Hypertension - September 13, 2020 Category: Cardiology Authors: Ferreira Miranda MT, Lemos MP, Sasaki JE, Mota GR, Marocolo M, de Sordi CC, Almeida TR, Dias da Silva VJ, Neto OB Tags: Clin Exp Hypertens Source Type: research

Calcitriol inhibits COX-1 and COX-2 expressions of renal vasculature in hypertension: Reactive oxygen species involved?
Abstract Vitamin D modulates about 3% human gene transcription besides the classical action on calcium/phosphorus homeostasis. The blood pressure-lowing and other protective action on cardiovascular disease have been reported. The present study aims to examine whether COX-1 and COX-2 were implicated in endothelial dysfunction in hypertension and calcitriol, an active form of vitamin D preserved endothelial function through regulating COX expression. Isometric study demonstrated the impaired endothelium-dependent relaxation (EDR) in renal arteries from spontaneously hypertensive rats were reversed by 12 h-calc...
Source: Clinical and Experimental Hypertension - September 9, 2020 Category: Cardiology Authors: Suo Z, Liu Y, Li Y, Xu C, Liu Y, Gao M, Dong J Tags: Clin Exp Hypertens Source Type: research

Decreased baroreflex sensitivity is associated with cardiometabolic risks and prehypertension status in early-postmenopausal women.
Abstract OBJECTIVE: We studied the link of decreased baroreflex sensitivity (BRS) to cardiometabolic risks and prehypertension status in postmenopausal women during their early menopausal phase. METHODS: Premenopausal women (n = 55) and early-postmenopausal women (n = 50) of age group between 40 and 55 years were recruited for the study, and their anthropometric parameters, complete battery of autonomic function tests (AFT), BRS, hormone levels, and cardiometabolic risk parameters were measured and compared between two groups. Correlation analysis of BRS with various physiological and biochemic...
Source: Clinical and Experimental Hypertension - September 7, 2020 Category: Cardiology Authors: Subhashri S, Pal P, Pal GK, Papa D, Nanda N Tags: Clin Exp Hypertens Source Type: research

Correlation of thioredoxin reductase (TrxR) and nitric oxide synthase (NOS) activities with serum trace elements in preeclampsia.
In this study, our aim was to evaluate the activity of eNOS and TrxR enzymes and the amounts of calcium, zinc, and selenium elements in serum of women with preeclampsia. MATERIAL AND METHODS: Thirty preeclampsia and 30 healthy pregnant women were enrolled in the study after clinical examination and confirmation by Obstetrician-Gynecologist. Venous blood samples were collected and the activity of NOS, TrxR enzymes, and the concentration of zinc, calcium, and selenium elements were measured in serum. RESULTS: The results of NOS and TrxR activities showed significant decreases in preeclampsia compared with control group (p
Source: Clinical and Experimental Hypertension - September 1, 2020 Category: Cardiology Authors: Mazloomi S, Khodadadi I, Alimohammadi S, Shafiee G Tags: Clin Exp Hypertens Source Type: research

Masked hypertension is related to alteration of myocardial arrhythmia Parameters.
This study evaluated the effects of masked hypertension on QT interval dynamicity. METHODS: The study group consisted of 108 consecutive patients with masked hypertension and 102 control subjects. Twenty-four-hour Holter monitoring was performed before anti-hypertensive treatment. CONTEC holter software was used to calculate HRV and QT dynamicity parameters. All subjects had a complete history, laboratory examination, and transthoracic echocardiography. RESULTS: There was no significant difference in age-gender distribution between patients and controls. Non-sustained VT was present in four patients (2.9%). SDNN,...
Source: Clinical and Experimental Hypertension - August 23, 2020 Category: Cardiology Authors: Yılmaz ÖÇ, Ozkan S, Yavuz B Tags: Clin Exp Hypertens Source Type: research

Relationship between blood pressure index and cognition in older adults.
CONCLUSION: The findings suggest that BPI is an associated with cognition in older adults and may a novel alternative marker for identifying the subjects at the risk of dementia. PMID: 32835518 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 23, 2020 Category: Cardiology Authors: Naharci MI, Katipoglu B Tags: Clin Exp Hypertens Source Type: research

Survival rate in hypertensive patients with COVID-19.
Abstract INTRODUCTION: A life-threatening respiratory disease, coronavirus 2019 (COVID-19), has spread across the globe since December 2019. Many prognostic factors have already been put forward to predict the risk of death and other outcomes. The current study is evaluating the survival rate between hypertensive and non-hypertensive infected patients. METHODS: Patients who were included in this study were admitted between 20 February to 1 March 2020 in Fars (southwest of Iran) province hospitals. Data were collected from the electronic base registry which contained demographic information, medical symptoms, ...
Source: Clinical and Experimental Hypertension - August 23, 2020 Category: Cardiology Authors: Emami A, Javanmardi F, Akbari A, Kojuri J, Bakhtiari H, Rezaei T, Keshavarzi A, Falahati F Tags: Clin Exp Hypertens Source Type: research

Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals.
This study was designed to evaluate the possible association between an exaggerated blood pressure (BP) response to exercise and subclinical vascular impairment in normotensive individuals. METHODS: The study participants consisted of 92 untreated normotensive men (aged 42 ± 9 years) without a history of cardiovascular disease or stroke. A graded exercise test was conducted using a bicycle ergometer, and the mean arterial pressure (MAP) during submaximal exercise was evaluated. The brachial-ankle pulse wave velocity (baPWV) was measured as an index of arterial stiffness. The second peak of radial...
Source: Clinical and Experimental Hypertension - August 15, 2020 Category: Cardiology Authors: Miyai N, Shiozaki M, Terada K, Takeshita T, Utsumi M, Miyashita K, Arita M Tags: Clin Exp Hypertens Source Type: research

The investigation of antioxidant and anti-inflammatory potentials of apitherapeutic agents on heart tissues in nitric oxide synthase inhibited rats via N ω-nitro-L-arginine methyl ester.
The investigation of antioxidant and anti-inflammatory potentials of apitherapeutic agents on heart tissues in nitric oxide synthase inhibited rats via Nω-nitro-L-arginine methyl ester. Clin Exp Hypertens. 2020 Aug 16;:1-8 Authors: Ozdemir B, Gulhan MF, Sahna E, Selamoglu Z Abstract BACKGROUND: High blood pressure effects heart and vessels. Development of pathogenesis is the result of oxidative stress. We aimed to investigate the antioxidant effects of propolis, caffeic acid phenethyl ester (CAPE), and pollen on the hearts of rats which chronic nitric oxide synthase (NOS) inhibited through N&ome...
Source: Clinical and Experimental Hypertension - August 15, 2020 Category: Cardiology Authors: Ozdemir B, Gulhan MF, Sahna E, Selamoglu Z Tags: Clin Exp Hypertens Source Type: research

Acute effects of body-weight resistance exercises on blood pressure and glycemia in middle-aged adults with hypertension.
he GB Abstract OBJECTIVE: The purpose of the present study was to evaluate the acute effects of single session of body-weight resistance exercises on blood pressure (BP) and glycemia in middle-aged adults with hypertension. METHODS: Twenty-three participants took part in this trial with crossover design and performed two experimental sessions in a random order: Body-weight resistance exercise session (BWR) and a control session without exercise. BWR was composed of four exercises: inverted row, squat, , and sit-ups. The participants performed 3 sets of 30 s, in which they were instructed to perform as much re...
Source: Clinical and Experimental Hypertension - August 10, 2020 Category: Cardiology Authors: Ferrari R, Cadore EL, Périco B, Kothe GB Tags: Clin Exp Hypertens Source Type: research

Association of serum VLDL level with hyperhomocysteinemia in hypertensive patients: A cross-sectional study.
Abstract BACKGROUND: Increasing evidence suggests that hyperhomocysteinemia (HHcy) and hyperlipidemia have been recognized as two independent risks for cardiovascular disease. However, the association between hyperlipidemia and HHcy in hypertensive patients has not been systemically elucidated. The aim of this study was to investigate the relation between very low-density lipoprotein (VLDL) and HHcy in hypertensive patients. METHODS: From July 2013 to March 2014, a large cross-sectional study was performed using 4012 participants from urban and rural communities in Hunan province, China. Participants underwen...
Source: Clinical and Experimental Hypertension - July 29, 2020 Category: Cardiology Authors: Chen J, Li J, Wang J, Zeng D, Chen J, Zhang Y, Wu M, Zhang D, Hong X Tags: Clin Exp Hypertens Source Type: research

Assessment of salusin alpha and salusin beta levels in patients with newly diagnosed dipper and non-dipper hypertension.
koyuncu B Abstract OBJECTIVE: The pathophysiology of non-dipper hypertension has not been clarified. The relationship between salusins with atherosclerosis and hypertension has gained attention in recent years. The aim of this paper is to investigate whether salusins are associated with circadian blood pressure, left ventricular mass index, and diastolic functions in newly diagnosed hypertensives. METHODS: The study included 88 newly diagnosed hypertensive individuals. Twenty-four-hour ambulatory blood pressure monitoring and echocardiographic examinations were performed. The patients were assigned to dipper ...
Source: Clinical and Experimental Hypertension - July 28, 2020 Category: Cardiology Authors: Alpsoy S, Dogan B, Ozkaramanli Gur D, Akyüz A, Fidan Ç, Guzel S, Ozkoyuncu B Tags: Clin Exp Hypertens Source Type: research

The link of depression, untreated hypertension, and diabetes with mortality in postmenopausal women: A cohort study.
Conclusions It is suggested we should take sufficient care of postmenopausal females with depression and control blood pressure and glucose more effectively. Abbreviations HP: Hypertension; DM: Diabetes; TC: Cholesterol; TG: Triglyceride; BMI: Body-Mass Index; CES-D: Center for Epidemiologic Studies Depression; CDC: Centers for Disease Control and Prevention; HR: Hazard Ratio; CI: Confidence Interval; ADL: Activities of daily living scale. PMID: 32715792 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - July 26, 2020 Category: Cardiology Authors: Guan S, Fang X, Gu X, Zhang Z, Tang Z, Wu X, Liu H, Wang C Tags: Clin Exp Hypertens Source Type: research

Aqueous extract of oakmoss produces antihypertensive activity in L-NAME-induced hypertensive rats through sGC-cGMP pathway.
CONCLUSION: The present study presents the favorable action of Oakmoss as an antihypertensive agent. PMID: 32706597 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - July 23, 2020 Category: Cardiology Authors: Amssayef A, Ajebli M, Eddouks M Tags: Clin Exp Hypertens Source Type: research

Pathophysiological significance of Stim1 mutation in sympathetic response to stress and cardiovascular phenotypes in SHRSP/Izm: In vivo evaluation by creation of a novel gene knock-in rat using CRISPR/Cas9.
Abstract Genetic approach using rat congenic lines between SHRSP/Izm and WKY/Izm identified stromal interaction molecule 1 (Stim1), an essential component of store-operated Ca2+ entry (SOCE), as a promising candidate gene responsible for the exaggerated sympathetic response to stress in SHRSP. Since SHRSP has a nonsense mutation in Stim1 resulting in the expression of a truncated form of STIM1 that caused reduction of SOCE activity in primary cultured cerebral astrocytes, we created SHRSP/Izm knocked-in with the wild-type Stim1 (KI SHRSP) by the CRISPR/Cas9 method to investigate whether the functional recovery of ...
Source: Clinical and Experimental Hypertension - July 22, 2020 Category: Cardiology Authors: Odongoo B, Ohara H, Ngarashi D, Kaneko T, Kunihiro Y, Mashimo T, Nabika T Tags: Clin Exp Hypertens Source Type: research

Increased epicardial adipose tissue thickness is associated with microalbuminuria in hypertensive patients with left ventricular hypertrophy.
This study aimed to investigate the relationship between echocardiographic EAT thickness and presence of MA in patients with hypertension. METHODS: A total of 297 newly diagnosed hypertension patients who applied to the outpatient clinic were enrolled consecutively in this study. Patients were divided into two groups regarding the presence of LVH in echocardiography. An age and gender matched control group was set including 156 healthy patients without HT. All subjects underwent transthoracic echocardiography for the measurement of EAT thickness. Spot urine samples were collected for the assessment of MA. RESULTS...
Source: Clinical and Experimental Hypertension - July 10, 2020 Category: Cardiology Authors: Eren H, Omar MB, Kaya Ü, Öcal L, İnanir M, GÖzek Öcal A, GenÇ Ö, GenÇ S, GÜner A, Yetİm M Tags: Clin Exp Hypertens Source Type: research

Clinical characteristics of concurrent primary aldosteronism and renal artery stenosis: A retrospective case-control study.
Abstract BACKGROUND: Rare cases of concurrent primary aldosteronism (PA) and renal artery stenosis (RAS) have been reported. METHODS: In this retrospective case-control study, we selected a cohort of 10 PA with RAS patients and a control group of 20 PA without RAS patients from January 1, 2006, to January 1, 2016. RESULTS: All patients presented with refractory hypertension, and a nonstatistically significant trend toward lower mean serum potassium was seen in the PA with RAS group (p =.07). PA with RAS patients had lower mean orthostatic aldosterone-to-renin ...
Source: Clinical and Experimental Hypertension - July 7, 2020 Category: Cardiology Authors: Meng X, Yang YK, Li YH, Fan P, Zhang Y, Yang KQ, Wu HY, Jiang XJ, Cai J, Zhou XL Tags: Clin Exp Hypertens Source Type: research

Pericardial adiposity versus body adiposity measured by BMI in the assessment of coronary atherosclerosis burden in patients with hypertension.
CONCLUSION: PFV showed a significant independent association with coronary calcification and significant coronary stenosis in patients with hypertension rather than BMI. PMID: 32643430 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - July 7, 2020 Category: Cardiology Authors: Nafakhi H, Al-Mosawi AA, Al Esawi RW Tags: Clin Exp Hypertens Source Type: research

The correlation of circulating miR-29b and inflammatory markers with albuminuria in hypertensive patients.
Abstract AIMS: Circulating miR-29b and inflammatory process play a vital role in hypertension and hypertensive nephropathy. The aim of the present study was to investigate the association of circulating miR-29b and inflammatory markers with albuminuria and assess the predictive value of circulating miR-29b for albuminuria in essential hypertension. METHODS: This cross-sectional study was continuously enrolled 150 subjects and were divided into three groups based on random urinary albumin/creatinine ratio (UACR, mg/g), the patients with ACR
Source: Clinical and Experimental Hypertension - July 6, 2020 Category: Cardiology Authors: Huang C, Huang YQ Tags: Clin Exp Hypertens Source Type: research

Effects of ACEi and ARB on post-exercise hypotension induced by exercises conducted at different times of day in hypertensive men.
Forjaz CLM Abstract BACKGROUND: Post-exercise hypotension (PEH) is greater after evening than morning exercise, but antihypertensive drugs may affect the evening potentiation of PEH. Objective: To compare morning and evening PEH in hypertensives receiving angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARB). METHODS: Hypertensive men receiving ACEi (n = 14) or ARB (n = 15) underwent, in a random order, two maximal exercise tests (cycle ergometer, 15 watts/min until exhaustion) with one conducted in the morning (7 and 9 a.m.) and the other in the evening...
Source: Clinical and Experimental Hypertension - June 25, 2020 Category: Cardiology Authors: Brito LC, Azevêdo L, Peçanha T, Fecchio RY, Rezende RA, da Silva GV, Pio-Abreu A, Mion D, Halliwill JR, Forjaz CLM Tags: Clin Exp Hypertens Source Type: research

Can ocular OCT findings be as a predictor for end-organ damage in systemic hypertension?
CONCLUSION: Hypertensive patients, especially with EOD had significantly lower SD-OCT parameters compared to controls. It would be rational to add SD-OCT assessment to conventional hypertensive retinopathy evaluation in patients with systemic hypertension for early diagnosis of end-organ damage, burden of target organ involvement and monitoring anti-hypertensive treatment. PMID: 32579082 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - June 23, 2020 Category: Cardiology Authors: Simsek EE, Kanar HS, Kanar BG, Cetin H, Arsan A, Tigen MK Tags: Clin Exp Hypertens Source Type: research

Association between diabetes mellitus and central arterial stiffness in elderly patients with systemic arterial hypertension.
CONCLUSIONS: Elderly patients with diabetes and hypertension have greater central arterial stiffness than patients without diabetes and hypertension, regardless of systemic blood pressure control. The central arterial stiffness caused by vascular aging seems to be a common factor among all the studied groups. PMID: 32574091 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - June 22, 2020 Category: Cardiology Authors: Galvão RDV, Pereira CS, Freitas EGB, Lima DRART, Santos WAM, Souza DF, Nomelini QSS, Ferreira-Filho SR Tags: Clin Exp Hypertens Source Type: research

Is the use of ACE inb/ARBs associated with higher in-hospital mortality in Covid-19 pneumonia patients?
CONCLUSION: The present study has found that the use of ACE inh/ARBs therapy might be associated with an increased in-hospital mortality in patients who were diagnosed with Covid-19 pneumonia. It is likely that ACE inh/ARBs therapy might not be beneficial in the subgroup of hypertensive Covid-19 patients despite the fact that there might be the possibility of some unmeasured residual confounders to affect the results of the study. PMID: 32569491 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - June 21, 2020 Category: Cardiology Authors: Selçuk M, Çınar T, Keskin M, Çiçek V, Kılıç Ş, Kenan B, Doğan S, Asal S, Günay N, Yıldırım E, Keskin Ü, Orhan AL Tags: Clin Exp Hypertens Source Type: research

Study on ferroptosis pathway that operates in hypertensive brain damage.
CONCLUSION: Thses findings suggest ferroptosis is closely related to hypertensive brain damage. Elevated blood pressure leads to iron overload in the brain. Excessive iron increases oxidative stress and lipid peroxidation in the brain, and eventually causes brain damage. PMID: 32564622 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - June 19, 2020 Category: Cardiology Authors: Yang J, Wang M, Wang S, Li G, Gao Y Tags: Clin Exp Hypertens Source Type: research

Effects of body mass index and gender on left atrial size in Chinese hypertensive patients.
Abstract BACKGROUND: Left atrial enlargement (LAE) is a common cardiac structural change in patients with hypertension, and obesity could further promote LAE. However, little is known about the effect of overweight on left atrial size, and if there is a gender difference of the effect. The aim of this study was to analyze the effects of different body mass index (BMI) grades (normal weight, overweight, and obesity) on left atrial size in both male and female patients with hypertension. METHODS: A total of 710 patients with hypertension were divided into 3 study groups: normal weight group (BMI
Source: Clinical and Experimental Hypertension - June 16, 2020 Category: Cardiology Authors: Chen X, Wu M, Xu K, Huang M, Xu H Tags: Clin Exp Hypertens Source Type: research

The association of exaggerated hypertensive response to exercise and beta-blockers use in hypertensives.
In this study, we evaluated patients who underwent treadmill exercise testing (TET) to reveal the effect of antihypertensive medication on HRE. MATERIALS AND METHODS: A cohort of 2970 individuals underwent TET and data were evaluated for HRE development. HRE has been defined as a systolic BP>210 mmHg in males and>190 mmHg in females throughout the TET. To reveal the effects of antihypertensive medication on HRE, 992 HT patients were analyzed. RESULTS: HRE was observed in 11.4% (n = 113) of HT patients and 5.9% (n = 107) of non-HT individuals(p
Source: Clinical and Experimental Hypertension - June 15, 2020 Category: Cardiology Authors: Mert KU, Şener E, Yılmaz AS, Mert GÖ, Yetmiş F, Dural M, Babayigit E, Murat S, Cavusoglu Y, Ulus T, Görenek B Tags: Clin Exp Hypertens Source Type: research

Fibrinogen to albumin ratio as a powerful predictor of the exaggerated morning blood pressure surge in newly diagnosed treatment-naive hypertensive patients.
u E Abstract BACKGROUND: The exaggerated morning blood pressure surge (MS) is a risk factor for cardiovascular diseases. Inflammation is associated with the pathogenesis of hypertension. We aimed to investigate the association between fibrinogen, albumin, fibrinogen to albumin ratio (FAR), and exaggerated MS, and which of those variables is a better predictor for identifying an exaggerated MS in newly diagnosed treatment-naive hypertensive patients. MATERIAL AND METHODS: The study included 249 treatment-naive patients who were newly diagnosed with hypertension in both clinical and ambulatory blood pressure (B...
Source: Clinical and Experimental Hypertension - June 11, 2020 Category: Cardiology Authors: Özdemir M, Yurtdaş M, Asoğlu R, Yildirim T, Aladağ N, Asoğlu E Tags: Clin Exp Hypertens Source Type: research

Comparison of nocturnal blood pressure based on home versus ambulatory blood pressure measurement: The Ohasama Study.
Conclusion: HBP monitoring may be a reliable alternative to ABP for the assessment of nocturnal BP. PMID: 32524845 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - June 10, 2020 Category: Cardiology Authors: Hosohata K, Kikuya M, Asayama K, Metoki H, Imai Y, Ohkubo T Tags: Clin Exp Hypertens Source Type: research

Home blood pressure on winter mornings could be exaggerated: A comparison with summer mornings.
This study aimed to investigate differences in HBP measured before and after getting up in winter and summer.Methods: Hypertensive subjects whose blood pressure was stably controlled were enrolled (n = 46, 73 years). They were instructed to measure HBP while in bed just after waking (HBP-bed), in addition to the ordinary HBP measurement in the morning (HBP-morning) according to the guidelines. The mean value of HBP for 7 consecutive days before the day of a regular hospital visit was considered as the HBP of each subject, and characteristics of the winter and summer BPs were investigated.Results: HBP-morning...
Source: Clinical and Experimental Hypertension - June 9, 2020 Category: Cardiology Authors: Mizoguchi T, Sugiura T, Dohi Y, Takase H, Yamashita S, Murai S, Seo Y, Ohte N Tags: Clin Exp Hypertens Source Type: research

Chemical renal denervation-induced upregulation of the ACE2/Ang (1-7)/Mas axis attenuates blood pressure elevation in spontaneously hypertensive rats.
Abstract OBJECTIVE: Evidence has shown that the ACE2/Ang (1-7)/Mas axis plays an important role in the control of hypertension. Thus, we hypothesized that chemical renal denervation (RDN) could reduce blood pressure by regulating the ACE2/Ang (1-7)/Mas axis in spontaneously hypertensive rats. METHODS: Twelve rats were randomly divided into sham group and chemical RDN group. All the rats were sacrificed 4 weeks later. Plasma samples were collected to measure the renin-angiotensin system (RAS) activities and reactive oxygen species levels by radioimmunoassay, chromatometry and ELISA. Paraventricular nucleu...
Source: Clinical and Experimental Hypertension - May 31, 2020 Category: Cardiology Authors: Han W, Wang M, Zhai X, Gan Q, Guan S, Qu X Tags: Clin Exp Hypertens Source Type: research

The role of serum interleukin-37 levels, inflammation and blood pressure in patients with preeclampsia.
CONCLUSIONS: Serum IL 37 concentrations were higher in preeclamptic patients compared to healthy pregnant women. Furthermore, IL 37 concentrations achieved success in identifying preeclampsia with hypertension. Increased IL 37 activity may have a role in the pathophysiology of preeclampsia. PMID: 32476486 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - May 31, 2020 Category: Cardiology Authors: Satiroglu O, Gürlek B, Durakoglugil ME, Duman H, Erdogan T, Çetin M, Ergül M, Yilmaz A, Uydu HA Tags: Clin Exp Hypertens Source Type: research

The regulatory effect of bromocriptine on cardiac hypertrophy by prolactin and D2 receptor modulation.
CONCLUSIONS: We concluded that bromocriptine has a protective effect on cardiac hypertrophy, and due to this effect, it may modulate the expression of Prlr and D2 r, which are involved in the development of cardiac hypertrophy. PMID: 32478610 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - May 31, 2020 Category: Cardiology Authors: Aguayo-Cerón KA, Calzada-Mendoza CC, Méndez-Bolaina E, Romero-Nava R, Ocharan-Hernández ME Tags: Clin Exp Hypertens Source Type: research

Increased masked hypertension prevalence in patients with polycystic ovary syndrome (PCOS).
dil;, Yavuz B Abstract OBJECTIVE: Polycystic ovary syndrome (PCOS) is a common disorder with important clinical consequences. Many studies have proven that hypertension is one of the most important comorbid disorders in PCOS. Masked hypertension is defined as a presence of normal office blood pressure together with abnormal results in 24-h ambulatory blood pressure monitoring (ABPM). The prevalence of this condition in patients with PCOS is not well defined. The aim of this study was to evaluate the prevalence of masked hypertension in PCOS compared to control subjects. METHODS: Sixty patients with PCOS an...
Source: Clinical and Experimental Hypertension - May 29, 2020 Category: Cardiology Authors: Özkan S, Yılmaz ÖÇ, Yavuz B Tags: Clin Exp Hypertens Source Type: research

Simulated vehicle exhaust exposure (SVEE) in rats impairs renal mitochondrial function.
Conclusion: Significant decline in mitochondrial respiration and oxygen consumption was observed, in addition to low ATP, reduced ATP synthase and cytochrome C oxidase levels, as well as accelerated mitochondrial fission, and reduced fusion processes, were observed in SVEE than CON rats, all indicative of renal mitochondrial impairment. PMID: 32423257 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - May 18, 2020 Category: Cardiology Authors: Kochi C, Pokkunuri I, Salvi A, Asghar M, Salim S Tags: Clin Exp Hypertens Source Type: research

Achievement rate of blood pressure < 140/90 mmHg and < 130/80 mmHg in subjects with hypertension; findings from a Japanese health checkup in 2017.
Achievement rate of blood pressure
Source: Clinical and Experimental Hypertension - May 17, 2020 Category: Cardiology Authors: Fujishima S, Kodama S, Tsuchihashi T Tags: Clin Exp Hypertens Source Type: research

CBF regulation in hypertension and Alzheimer's disease.
Conclusion: We conclude with the suggestion that the sensory elements pathology plays important roles in intertwined mechanisms of chronic high MAP and AD that impact cerebral perfusion. PMID: 32420765 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - May 17, 2020 Category: Cardiology Authors: Yazdani N, Kindy MS, Taheri S Tags: Clin Exp Hypertens Source Type: research

Clinical characteristics of coronavirus disease 2019 (COVID-19) patients with hypertension on renin-angiotensin system inhibitors.
In conclusions, the COVID-19 patients with a history of hypertension had a significantly lower lymphocyte count on admission. The elderly and comorbidities such as hypertension may together constitute risk factors for poor prognosis in patients with COVID-19. Taking ACEI or ARB drugs may not change the prognosis of COVID-19 patients with hypertension. PMID: 32404011 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - May 12, 2020 Category: Cardiology Authors: Zhou X, Zhu J, Xu T Tags: Clin Exp Hypertens Source Type: research

Effects of blackcurrant extract on arterial functions in older adults: A randomized, double-blind, placebo-controlled, crossover trial.
Conclusion: These results suggest that short-term NZBC intake reduces central arterial stiffness and central blood pressure in older adults. Therefore, anthocyanin-rich blackcurrants might be beneficial for maintaining or improving cardiovascular health as an alternative to pharmaceutical medications.Abbreviations: Aix: augmentation index; BP: blood pressure; cfPWV: carotid-femoral pulse-wave velocity;  CVD: cardiovascular diseases; DBP: diastolic blood pressure;  faPWV: femoral-ankle pulse-wave velocity; FG: fasting glucose; HDL: high-density lipoprotein cholesterol; LDL: low-density lipoprotein cholesterol; MBP...
Source: Clinical and Experimental Hypertension - May 11, 2020 Category: Cardiology Authors: Okamoto T, Hashimoto Y, Kobayashi R, Nakazato K, Willems MET Tags: Clin Exp Hypertens Source Type: research

Hyperinsulinemia rather than insulin resistance itself induces blood pressure elevation in high fat diet-fed rats.
Conclusions: It is the compensatory hyperinsulinemia rather than insulin resistance per se that causes blood pressure elevation. The urinary sodium excretion is the key mediator among the multiple mechanisms. Therapies targeting hyperinsulinemia and restricting salt intake may favor a better control of hypertension associated with insulin resistance. PMID: 32349626 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - April 29, 2020 Category: Cardiology Authors: Wang H, Tian Y, Chen Y, Shen X, Pan L, Li G Tags: Clin Exp Hypertens Source Type: research

Values of serum sFlt-1, PLGF levels, and sFlt-1/PLGF ratio in diagnosis and prognosis evaluation of preeclamptic patients.
Conclusion: sFlt-1/PLGF ratio is valuable for assessing the severity of preeclampsia and diagnosing E-PE, and can be used to predict neonatal birth weight. PMID: 32338084 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - April 24, 2020 Category: Cardiology Authors: Zhu X, Chen L, Li R Tags: Clin Exp Hypertens Source Type: research

Impact of visit-to-visit variability in blood pressure on coronary plaque as assessed by integrated backscatter intravascular ultrasound.
Abstract Introduction: Visit-to-visit variability (VVV) in blood pressure (BP) has been reported to be a strong predictor of cardiovascular disease. However, the association between VVV in BP and coronary plaque composition has not been fully elucidated.Methods: One hundred-two consecutive patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI) using integrated backscatter (IB) intravascular ultrasound (IVUS), and who had at least six clinic visits a year before PCI were included. We measured systolic and diastolic BP (SBP and DBP) at each visit and determined VVV in BP e...
Source: Clinical and Experimental Hypertension - April 20, 2020 Category: Cardiology Authors: Kato Y, Iwata A, Futami M, Yamashita M, Shigemoto E, Kuwano T, Sugihara M, Miura SI Tags: Clin Exp Hypertens Source Type: research

High cardiovascular reactivity and muscle strength attenuate hypotensive effects of isometric handgrip training in young women: A randomized controlled trial.
This study aimed to investigate the potential hypotensive effects of isometric training and their association with cardiovascular reactivity to acute isometric exercise and muscle strength in young women.Methods: In this randomized trial, twenty young women were randomly assigned to either the training (n = 10) or control (n = 10) group. Women from the training group performed unilateral isometric handgrip sessions for 8 weeks (4 × 2 min at 25% of maximal voluntary contraction [MVC]; 3 days/week). Cardiovascular reactivity to acute isometric exercise and MVC were measured ...
Source: Clinical and Experimental Hypertension - April 3, 2020 Category: Cardiology Authors: Yamagata T, Sako T Tags: Clin Exp Hypertens Source Type: research