Add-on aliskiren treatment can decrease blood pressure but requires attention to risks of renal impairment and hyperkalemia Chikushi Anti-Hypertension Trial-Rasilez ® (CHAT-Ras).
This study was a multi-center, open-label, prospective, observational study. Study subjects were patients with essential HT and poor blood pressure (BP) control, who had received calcium channel blocker monotherapy or angiotensin II receptor blocker monotherapy or had not received any BP lowering drugs. Following add-on of AL for 12 months, BP and additional laboratory findings were analyzed.Results: A total of 150 subjects were enrolled. There were 50 dropout subjects including discontinuation. Dropouts were the highest in the ARB combination therapy group at 9 subjects due to adverse events, and 3 of them were due t...
Source: Clinical and Experimental Hypertension - February 8, 2020 Category: Cardiology Authors: Okamura K, Takamiya Y, Mori K, Shirai K, Urata H Tags: Clin Exp Hypertens Source Type: research

Effects of eplerenone on cerebral aldosterone levels and brain lesions in spontaneously hypertensive rats.
Abstract Evidence indicates that renin-angiotensin-aldosterone system (RAS) inhibitors can protect the brain in Alzheimer's disease and Parkinson's disease. The current study evaluated the relationship between aldosterone and tissue damage in the brains of spontaneously hypertensive rats (SHRs) and whether the RAS inhibitor eplerenone can mitigate the damage seen in these rats.SHRs were randomly divided into eplerenone (n = 10) and SHR (n = 10) groups, and Wistar-Kyoto (WKY) rats (n = 10) were used as controls. Eplerenone 50 mg/kg/day was administered orally to the eplerenone group. P...
Source: Clinical and Experimental Hypertension - February 5, 2020 Category: Cardiology Authors: Wang X, Zhu Y, Wang S, Wang Z, Sun H, He Y, Yao W Tags: Clin Exp Hypertens Source Type: research

Study of correlations between metabolic risk factors, PWV and hypertension in college students.
This study focused on college students and correlations between serum lipids, serum uric acid, fasting plasma glucose, serum creatinine, body mass index, brachial-ankle pulse wave velocity and hypertension. The results suggested that there was no relevance between serum lipids and hypertension. However, it came out that hypertension is associated with normal fasting plasma glucose, BMI (thinness and normal weight), normal serum creatinine. Methods: A total of 5185 students were enrolled, and their blood pressure, height and weight were measured. 285 of the students were selected to take physical examinations including seru...
Source: Clinical and Experimental Hypertension - February 4, 2020 Category: Cardiology Authors: Ji X, Zhao H, Wang M, Li Y, Zhang C, Wang X Tags: Clin Exp Hypertens Source Type: research

Bisoprolol transdermal patch improves orthostatic hypotension in patients with chronic heart failure and hypertension.
Abstract β blockers (BBs) play an important role in heart failure (HF) treatment. However, orthostatic hypotension (OH) is sometimes caused by BBs. The bisoprolol transdermal patch works more slowly and is long acting compared with the bisoprolol fumarate tablet. The risk of OH may be reduced by using the bisoprolol transdermal patch. We evaluated 57 consecutive patients who were taking the bisoprolol fumarate tablet for chronic HF with hypertension from November 2016 to September 2017. We switched the patients to the bisoprolol transdermal patch. Because 12 of 57 subjects could not continue using the bisopro...
Source: Clinical and Experimental Hypertension - February 2, 2020 Category: Cardiology Authors: Kiuchi S, Hisatake S, Kabuki T, Oka T, Dobashi S, Fujii T, Sano T, Ikeda T Tags: Clin Exp Hypertens Source Type: research

Effects of showing the operating room on preoperative anxiety and hemodynamics among patients with hypertension: A randomized controlled trial.
Conclusion: In patients with hypertension, preoperative anxiety, blood pressure, heart rate, and respiratory rate all increase in the preoperative unit and operation room. Our findings indicate that showing the operating room to patients with hypertension decreases preoperative anxiety, as well as blood pressure and heart rate inside the operating room and preoperative unit. It also reduces the number of postponed operations and increases patient satisfaction. PMID: 32009491 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - February 2, 2020 Category: Cardiology Authors: Yuzkat N, Soyalp C, Turk O, Keskin S, Gulhas N Tags: Clin Exp Hypertens Source Type: research

Protective effects of resveratrol and SR1001 on hypoxia-induced pulmonary hypertension in rats.
This study is designed to examine the effects of combined prevention with resveratrol and SR1001 on HPH in rats. The effects of combined prevention with resveratrol and SR1001 and each mono-prevention on the development of HPH, Th17 cells differentiation, expression of guanine nucleotide exchange factor-H1 (GEF-H1), Ras homolog gene family member A (RhoA) and Phosphorylated myosin phosphatase target subunit (MYPT1) were examined. HPH and RV hypertrophy occurred in rats exposed to hypoxia. Compared with normoxia group, the hypoxia group showed significantly increased ratio of Th17 cells. After treatment with resveratrol, HP...
Source: Clinical and Experimental Hypertension - January 23, 2020 Category: Cardiology Authors: Li C, Peng G, Long J, Xiao P, Zeng X, Yang H Tags: Clin Exp Hypertens Source Type: research

A post-marketing survey evaluating the safety and efficacy of a fixed-dose single-pill combination of cilnidipine and valsartan in patients with hypertension: Real-world JSH 2014 and 2019 implementations.
Abstract Methods: The home blood pressure control by a single-pill combination of cilnidipine and valsartan (HOPE-Combi) survey sought to evaluate the safety and efficacy of cilnidipine 10 mg/valsartan 80 mg single-pill combination (SPC of Cil/Val) treatment in patients with hypertension for over 12 months. Of 2622 subjects' data; we analyzed 2572 cases for safety and 2372 cases for efficacy.Results: Adverse drug reaction (ADR) incidence rate was 3.77% (97 of 2572 patients). The frequency of ADRs did not differ between patients aged
Source: Clinical and Experimental Hypertension - January 22, 2020 Category: Cardiology Authors: Matsuda S, Nagahama S, Kurose Y, Wakabayashi M, Sugii H, Teshima T, Suzuki N, Kario K Tags: Clin Exp Hypertens Source Type: research

Moringa oleifera leaf extract induces vasorelaxation via endothelium-dependent hyperpolarization and calcium channel blockade in mesenteric arterial beds isolated from L-NAME hypertensive rats.
Conclusion: These findings suggest that MOE relaxes mesenteric arterial beds of L-NAME hypertensive rats via both endothelium-dependent and endothelium-independent mechanisms. The endothelium-dependent action occurred via endothelium-derived hyperpolarizing factor-mediated hyperpolarization. The endothelium-independent action was related to blocking the entry of extracellular Ca2+ via voltage-operated and receptor-operated Ca2+ channels, and inhibiting mobilization of sarcolemmal Ca2+ via inositol trisphosphate receptor Ca2+ channels. MOE may be potentially useful as a natural vasodilator against hypertension. PMID: 3...
Source: Clinical and Experimental Hypertension - January 22, 2020 Category: Cardiology Authors: Aekthammarat D, Pannangpetch P, Tangsucharit P Tags: Clin Exp Hypertens Source Type: research

Association between cardiovascular risk factors and stage 1 hypertension defined by the 2017 ACC/AHA guidelines.
This study was conducted to assess the association of cardiovascular risk factors (CRFs) and newly defined stage 1 hypertension in China.Methods: We analyzed the data of 84,489 adults with a BP of
Source: Clinical and Experimental Hypertension - January 18, 2020 Category: Cardiology Authors: Liu XZ, Chen DS, Di FP, Shi CY, Li HH, Wang JM, Ji YX Tags: Clin Exp Hypertens Source Type: research

Comparison of cuff-based and cuffless continuous blood pressure measurements in children and adolescents.
Abstract Objective: In recent times, new methods of blood pressure measurements have been introduced, including cuffless blood pressure (BP) measurement device using pulse transit time (PTT) for calculation of BP values. However, it is still unknown how values obtained with a new cuffless device compare with standard ambulatory measurements in children. The main aim of the study was to investigate whether BP values measured by a cuffless PTT device are comparable with measurements by a standard upper arm cuff-based BP device.Methods: Thirty children were prospectively included. Blood pressure measurements using th...
Source: Clinical and Experimental Hypertension - January 15, 2020 Category: Cardiology Authors: Zachwieja J, Neyman-Bartkowiak A, Rabiega A, Wojciechowska M, Barabasz M, Musielak A, Silska-Dittmar M, Ostalska-Nowicka D Tags: Clin Exp Hypertens Source Type: research

Evaluation of atrial electromechanical properties in patients with masked hypertension.
In this study, we evaluated the electromechanical properties of atriums in patients with masked hypertension by using tissue Doppler echocardiographic technique to predict the predisposition to atrial arrhythmias.Methods: A total of 118 subjects were included in the study. Twenty-four-hour blood pressure monitorization (ABPM) was used to determinate the masked hypertension in the study group. Tissue Doppler imaging was used to find intra-left and -right atrial electromechanical delay (AEMD) and inter-atrial electromechanical delay. The results compared between patients with masked hypertension and without.Results: There we...
Source: Clinical and Experimental Hypertension - January 14, 2020 Category: Cardiology Authors: Özkan S, Yılmaz ÖÇ, Yavuz B Tags: Clin Exp Hypertens Source Type: research

Increased rate of any retinopathy risk in patients with masked hypertension.
In this study, we aimed to investigate retinopathy in masked hypertensive patients.Methods: We enrolled 92 patients with masked hypertension and 87 healthy controls in to the study. We use ambulatory blood pressure monitoring (ABPM) to detect the masked hypertension. Bilateral fundus examination was performed. Hypertensive retinopathy (HTRP) grading was determined according to the Keith-Wagener-Barker classification. We examined retinopathy grade in patients with masked hypertension and without.Results: 55 (11.6%) participants had signs of retinopathy. Fifty (54.3%) subjects had any retinopathy in patients with masked hype...
Source: Clinical and Experimental Hypertension - December 19, 2019 Category: Cardiology Authors: Yıldırım T, Özkan S, Yılmaz ÖÇ, Yavuz B Tags: Clin Exp Hypertens Source Type: research

Roles of arterial pressure volume index and arterial velocity pulse index trajectories in risk prediction in hypertensive patients with heart failure with preserved ejection fraction.
Conclusion: High API/AVI trajectories are strong predictors of cardiovascular risk in hypertensive patients with HFpEF. Among these patients, measuring API/AVI may improve risk stratification and provide additional information to tailor treatment strategies. PMID: 31851528 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - December 18, 2019 Category: Cardiology Authors: Wan J, Liu S, Yang Y, Wang D, Ran F, Xia S, Ma S, Hou J, Zhou P, Sun Y, Wang P Tags: Clin Exp Hypertens Source Type: research

Associations between honey consumption and prehypertension in adults aged 40 years and older.
Conclusion: Our results showed that light-to-moderate intake of honey was associated with lower prevalence of prehypertension in women, but not men. Future studies are required to confirm these associations. PMID: 31760826 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 23, 2019 Category: Cardiology Authors: Zhang S, Lu Z, Tian C, Zhang Q, Liu L, Meng G, Yao Z, Wu H, Xia Y, Bao X, Gu Y, Sun S, Wang X, Zhou M, Jia Q, Sun Z, Song K, Niu K Tags: Clin Exp Hypertens Source Type: research

Efficacy and safety of a combination antihypertensive drug (olmesartan plus azelnidipine): "Issues with hypertension studies in real-world practice".
Conclusion: The results of this study suggested that switching from a single drug to combination therapy with REZ could achieve a stronger antihypertensive effect. However, concern was raised regarding the methods of BP and PR measurement and recording in this clinical trial involving general practitioners. PMID: 31756122 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 22, 2019 Category: Cardiology Authors: Okamura K, Yano Y, Takamiya Y, Shirai K, Urata H Tags: Clin Exp Hypertens Source Type: research

CXCL2, a new critical factor and therapeutic target for cardiovascular diseases.
Abstract Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Previous studies have shown that inflammatory chemokines are involved in the physiological functions of cytoskeletal reorganization, cell migration, adhesion and immune responses. However, in the past decade, there have been studies showing that inflammatory chemokines play a key role in CVD. Importantly, CXC motif chemokine ligand 2 (CXCL2) has been shown to be involved in the pathogenesis of cardiovascular disease. CXCL2 exerts its effects on the cardiovascular system by mediating inflammatory responses, but the specific signaling ...
Source: Clinical and Experimental Hypertension - November 21, 2019 Category: Cardiology Authors: Guo LY, Yang F, Peng LJ, Li YB, Wang AP Tags: Clin Exp Hypertens Source Type: research

Acute volume expansion decreased baroreflex response after swimming but not after running exercise training in hypertensive rats.
Conclusion: The results show that the swim-trained group has a different baroreflex response to that observed by the run-trained group after the activation of the load receptors by saline expansion. PMID: 31746245 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 20, 2019 Category: Cardiology Authors: Raimundo Fernades ÉM, de Moura SS, Silva RO, Totou NL, Baleeiro RDS, de Oliveira EC, Coelho DB, Cardoso LM, Becker LK Tags: Clin Exp Hypertens Source Type: research

Characteristic dietary habits associated with high values of estimated 24-hours urinary sodium excretion and sodium-to-potassium ratio assessed by age group among the residents of a rural town in Japan.
We examined estimated 24-h urinary sodium (Na) excretion and sodium-to-potassium (Na/K) ratio and analyzed the association between estimated 24-h urinary salt excretion (urinary salt excretion) and dietary habits by age group to develop effective public health programs to promote salt reduction. A total of 4,051 subjects aged 30-74 years old received information during periodic health checkups. In the analysis, 1,202 subjects without hypertension whose urine samples and dietary habits were confirmed (29.7%; 483 men and 719 women) were included. The median urinary salt excretion was 9.1 g/day in men and 8.6 g/day in women. ...
Source: Clinical and Experimental Hypertension - November 20, 2019 Category: Cardiology Authors: Seko C, Odani K, Wada S, Yoshii K, Segawa H, Kitaoka K, Masumoto T, Higashi A Tags: Clin Exp Hypertens Source Type: research

Edaravone and benidipine protect myocardial damage by regulating mitochondrial stress, apoptosis signalling and cardiac biomarkers against doxorubicin-induced cardiotoxicity.
Conclusion: Taken together these results suggest that the pretreated with edaravone and benidipine have potential protective effect against DOX-induced cardiotoxicity. PMID: 31630586 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 20, 2019 Category: Cardiology Authors: Hassan MQ, Akhtar MS, Afzal O, Hussain I, Akhtar M, Haque SE, Najmi AK Tags: Clin Exp Hypertens Source Type: research

Liraglutide reduces systolic blood pressure in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials.
Abstract The antidiabetic effect of liraglutide in patients with type 2 diabetes mellitus has been explored in several trials. We performed this meta-analysis determining the effects of liraglutide on blood pressure in these patients. Three electronic databases (Pubmed, Web of Science, and Cochrane Central) were searched for all published articles evaluating the effects of liraglutide on blood pressure in subjects with type 2 diabetes mellitus. Total 968 patients were included in 10 randomized, double-blind, placebo-controlled trials with a follow-up of 16 ± 9 weeks. Liraglutide 1.8 mg/day reduced systolic ...
Source: Clinical and Experimental Hypertension - October 15, 2019 Category: Cardiology Authors: Zhao D, Liu H, Dong P Tags: Clin Exp Hypertens Source Type: research

Association of insulin resistance with polymorphic variants of Clock and Bmal1 genes: A case-control study.
This study aimed to investigate the relationship of HOMA-IR (homeostasis model assessment of insulin resistance) to polymorphic variants of Clock and Bmal1 genes in Chinese patients with essential hypertension. Methods: A total of 334 outpatients with essential hypertension (103 patients of HOMA-IR positive and 231 patients of HOMA-IR negative) were recruited to analyze Clock T3111C and Bmal1 A1420G genotypes with DNA sequencing approach. Results: Waist circumference, body mass index, glycated hemoglobin, total cholesterol, triglyceride, and plasminogen activator inhibitor-1 were significantly increased, while high-density...
Source: Clinical and Experimental Hypertension - October 15, 2019 Category: Cardiology Authors: Li GY, Wang H, Chen H Tags: Clin Exp Hypertens Source Type: research

Acute Hemodynamic Responses to Repetitions to Failure Using Different Resistance Exercises and Protocols in Normotensive Men: A crossover study.
Abstract The present crossover design study investigated acute hemodynamic responses to two sets of leg press (LP) and bench press (BeP) at 10 and 20 repetition maximum (RM) in ten normotensive young men. At the end of each set, an increase in systolic blood pressure (SBP), heart rate (HR), and rate pressure product (RPP) was observed (p
Source: Clinical and Experimental Hypertension - October 8, 2019 Category: Cardiology Authors: Machado CLF, Bgeginski R, De Castro C, Wilhelm EN, Pinto RS Tags: Clin Exp Hypertens Source Type: research

Orthostatic change in systolic blood pressure associated with cold pressor reflection and heart rate variability in the elderly.
Abstract Background: Impaired orthostatic blood pressure (BP) response is a frequent finding in the elderly. The goal of the study was to investigate the association of variability of supine-to-orthostatic BP with cold pressor reflection and heart rate variability in the elderly. Methods: From June 2010 to September 2013, 287 elderly aged ≥ 60 years were enrolled in Jinan area, China. The elderly were classified into lower (n = 96), intermediate (n = 95), and higher (n = 96) tertile groups according to the tertile of the percentage change of supine-to-orthostatic systolic BP. Results: There ...
Source: Clinical and Experimental Hypertension - October 7, 2019 Category: Cardiology Authors: Dong Y, Cui Y, Zhang H, Liu Z, Wang J Tags: Clin Exp Hypertens Source Type: research

Cerebral microbleeds are associated with blood pressure levels in individuals with hypertension.
Conclusions: This study provides novel evidence that microbleed severity is associated with hypertension grade. This conclusion emphasizes the importance of antihypertensive therapy in hypertension patients to avoid an increase in CMBs. PMID: 31542967 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - September 22, 2019 Category: Cardiology Authors: Lyu L, Shen J, Zeng C, Ji J, Hu W, Wei T, Mao W Tags: Clin Exp Hypertens Source Type: research

Combination therapy with an Xa inhibitor and antihypertensive agent improved anticoagulant activity in patients with nonvalvular atrial fibrillation: the hypertension and atrial fibrillation treated by rivaroxaban for the morning and night with sYnergy with calcium antagonists (HARMONY) study.
Abstract Background: Anticoagulant activity and blood pressure increase in the morning. The aim of this study was to evaluate changes of anticoagulant activity, blood pressure and target organ damage in patients with nonvalvular atrial fibrillation (AF) given combination treatment with Xa inhibitor and antihypertensive agent. Methods: We enrolled 72 patients with nonvalvular AF. Rivaroxaban (10-15 mg) was continuously administered once daily over 8 weeks (study period I). For subjects (n = 50) who exhibited uncontrolled morning hypertension (home systolic blood pressure [SBP]≥125 mmHg) at the end of study ...
Source: Clinical and Experimental Hypertension - September 21, 2019 Category: Cardiology Authors: Kabutoya T, Ohmori T, Fujiwara T, Kario K Tags: Clin Exp Hypertens Source Type: research

Juglone as antihypertensive agent acts through multiple vascular mechanisms.
Conclusion: In conclusion, juglone exerts its antihypertensive effect through vasorelaxation, which is mediated by nitric oxide, inhibition of intracellular calcium release and opening of K+-channels. PMID: 31523996 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - September 15, 2019 Category: Cardiology Authors: Ahmad T, Khan T, Alamgeer, Shah AJ Tags: Clin Exp Hypertens Source Type: research

Differential Expression of Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF) in Different Regions of Normal and Preeclampsia Placentae.
This study examines the mRNA levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in different regions of the placenta in normotensive control (NC) women and women with PE. Thirty NC women and forty one women with PE (18 delivered at term [T-PE] and 23 delivered preterm [PT-PE]) were included in the study. Placental samples were taken from four regions: central basal (CM), central chorionic (CF), peripheral basal (PM), and peripheral chorionic (PF). The mRNA levels of neurotrophins were measured by quantitative real-time PCR. Results: The BDNF mRNA levels were higher in peripheral fetal region a...
Source: Clinical and Experimental Hypertension - September 14, 2019 Category: Cardiology Authors: Sahay AS, Jadhav AT, Sundrani DP, Wagh GN, Joshi SR Tags: Clin Exp Hypertens Source Type: research

Dietary capsaicin-mediated attenuation of hypertension in a rat model of renovascular hypertension.
Conclusion: Dietary capsaicin may alleviate 2K1C renovascular hypertension, probably via enhancing phosphorylation of Akt and eNOS. Abbreviations: 2K1C: 2-kidney, 1-clip hypertension model; Akt: protein kinase B; Ang II: angiotensin II; ANOVA: measures analysis of variance; BP: blood pressure; EC: endothelial cell; eNOS: endothelial nitric oxide synthase; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; L-NAME, LN: Nω-Nitro-L-arginine methyl ester hydrochloride; MA: mesenteric arteries; MAP: mean arterial blood pressure; NO: nitric oxide; PKA: protein kinase A; PVDF: polyvinylidene difluoride; SBP: Systolic blood pre...
Source: Clinical and Experimental Hypertension - September 13, 2019 Category: Cardiology Authors: Segawa Y, Hashimoto H, Maruyama S, Shintani M, Ohno H, Nakai Y, Osera T, Kurihara N Tags: Clin Exp Hypertens Source Type: research

The acute effects of different frequencies of whole-body vibration on arterial stiffness.
This study involved 9 healthy men (age: 31 ± 7 years). Each WBV session involved 3 sets of 4 different vibrations (0 Hz [control], 12 Hz, 20 Hz, 30 Hz) lasting 60 s with a 60-s inter-session rest interval. During WBV, the participants adopted a static squat position with their knees bent. An automatic oscillometric device was used to measure brachial-ankle pulse wave velocity (baPWV) before (baseline) and 5, 15, and 30 min after WBV. There was a significant decrease in baPWV from baseline at 30 min (P = .02) after WBV at 30 Hz. However, there was no cha...
Source: Clinical and Experimental Hypertension - September 12, 2019 Category: Cardiology Authors: Kim E, Okamoto T, Song J, Lee K Tags: Clin Exp Hypertens Source Type: research

Changes in community pharmacists' knowledge, attitudes, and practice regarding the management of hypertension before and after educational interventions.
Conclusions: These findings suggest that in-house training might increase the knowledge of community pharmacists regarding hypertension management. PMID: 31423854 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 17, 2019 Category: Cardiology Authors: Noda A, Obara T, Takada K, Kishikawa Y, Abe S, Yoshimachi S, Mano N, Imai Y, Goto T Tags: Clin Exp Hypertens Source Type: research

Effects of aerobic exercise training on the arterial stiffness and intramyocellular or extramyocellular lipid in overweight and obese men.
Abstract Intramyocellular lipid (IMCL) and extramyocellular lipid (EMCL) of ectopic fat in muscles are associated with arterial stiffness in normal-weight individuals. Furthermore, aerobic exercise training-induced changes in IMCL or EMCL content are related to a decrease in arterial stiffness in elderly people. Though arterial stiffness is strongly related with obesity, but the effects of aerobic exercise training on IMCL or EMCL content, with a particular focus on arterial stiffness, in obese individuals remains unclear. Here, we investigated the effects of aerobic exercise training on IMCL or EMCL content and a...
Source: Clinical and Experimental Hypertension - August 8, 2019 Category: Cardiology Authors: Park J, Choi Y, Myoenzono K, Yoshikawa T, Tagawa K, Isobe T, Saotome K, Sankai Y, Shimojo N, Maeda S Tags: Clin Exp Hypertens Source Type: research

Management instructions for elderly patients with hypertension.
Conclusions: Elderly patients with hypertension (aged ≥75 years) require daily BP monitoring and detailed and repeated explanation of hypertension and BP targets. PMID: 31393175 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 8, 2019 Category: Cardiology Authors: Ikeda Y, Sasaki T, Kuwahata S, Imamura M, Tanoue K, Komaki S, Hashiguchi M, Kuroda A, Akasaki Y, Ohishi M Tags: Clin Exp Hypertens Source Type: research

Association of cardiovascular risk factor clustering and prehypertension among adults :Results from the China health and retirement longitudinal study baseline.
Conclusions: This study indicated that CVD risk factor clustering was significantly associated with prehypertension and hypertension. These results provide valuable information for health professionals to better understand the impact of CVD risk factor clustering on prehypertension and hypertension. PMID: 31394956 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 8, 2019 Category: Cardiology Authors: Tang L, Zhao Q, Han W, Li K, Li J Tags: Clin Exp Hypertens Source Type: research

Serum endocan levels, carotid intima-media thickness and microalbuminuria in patients with newly diagnosed hypertension.
Abstract Background: Endocan is a particular protein of endothelial cells. The purpose of this study was to determine the relationship of serum endocan levels with carotid intima-media thickness (cIMT), inflammation, and microalbuminuria in patients with newly-diagnosed hypertension. Materials-Methods: This prospective study included 61 patients with newly-diagnosed hypertension (HT) and 30 controls. Endocan, microalbuminuria and cIMT measurements were taken from all patients. Results: The serum endocan levels, the mean cIMT and microalbuminuria levels of patients with HT were significantly higher than those of the control group (p
Source: Clinical and Experimental Hypertension - August 7, 2019 Category: Cardiology Authors: Oktar SF, Guney I, Eren SA, Oktar L, Kosar K, Buyukterzi Z, Alkan E, Biyik Z, Erdem SS Tags: Clin Exp Hypertens Source Type: research

The association of four-limb blood pressure differences with cardiovascular risk factors and target organ changes in elderly Chinese: The Northern Shanghai Study.
This study aims at investigating the association of those parameters with cardiovascular risk factors and TOCs in an elderly Chinese population. Methods: A total of 1528 subjects derived from the Northern Shanghai Study were studied. Four-limb BPs were simultaneously measured by VP-1000 device. Cardiovascular risk factors and TOCs including parameters of left ventricular structure and function, carotid intima-media thickness, carotid-femoral pulse-wave velocity (CF-PWV), estimated glomerular filtration rate (eGFR) and urinary albumin/creatinine ratio, were evaluated with standardized methods. Results: ABI significantly ass...
Source: Clinical and Experimental Hypertension - August 5, 2019 Category: Cardiology Authors: Yu S, Lu Y, Xiong J, Bai B, Teliewubai J, Chi C, Blacher J, Li J, Zhang Y, Xu Y Tags: Clin Exp Hypertens Source Type: research

Wave reflections and systemic vascular resistance are stronger determinants of pulse pressure amplification than aortic stiffness in drug-na ïve hypertensives.
Conclusion: This study shows that among newly-diagnosed drug-naïve hypertensives, elevated wave reflections and systemic vascular resistance are stronger determinants of PP amplification than aortic stiffness. PMID: 31379216 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 3, 2019 Category: Cardiology Authors: Papakonstantinou E, Pikilidou M, Georgianos P, Yavropoulou M, Tsivgoulis G, Hadjistavri L, Nanoudis S, Liakopoulos V, Lasaridis A, Zebekakis P Tags: Clin Exp Hypertens Source Type: research

High-intensity interval training irrespective of its intensity improves markers of blood fluidity in hypertensive patients.
Abstract Aim: The present study examined and compared the effects of two different HIIT (High-intensity interval training) protocols on markers of blood fluidity in hypertensive patients. Methods: Thirty hypertensive (stage 1, systolic BP>140 and diastolic BP>90 mmHg) patients (age, 47.96 ± 3.20 yrs), were randomly allocated to short-duration HIIT (SDHIIT, n = 10), long-duration HIIT (LDHIIT, n = 10), and control (n = 10) groups. After 2 weeks of continuous mild training, patients in SDHIIT group performed 8 weeks of HIIT included 27 min HIIT that encompassed 27 repetitions of 30 s activity at 80%-100...
Source: Clinical and Experimental Hypertension - July 30, 2019 Category: Cardiology Authors: Soltani M, Aghaei Bahmanbeglou N, Ahmadizad S Tags: Clin Exp Hypertens Source Type: research

Body mass index predicts aldosterone production in hypertensive postmenopausal women.
Abstract Hypertension is a common clinical problem, and increased aldosterone is the most prevalent underlying characteristic. Related works have shown exciting results on the effects of various conditions on aldosterone content, but the correlation between aldosterone levels and body mass index (BMI) in premenopausal women has not yet been investigated. We herein report a cross-sectional analysis aimed to determine whether BMI is proportional to plasma aldosterone concentration in premenopausal and postmenopausal hypertensive women. The analysis of consecutive admitted female patients with hypertension revealed p...
Source: Clinical and Experimental Hypertension - July 30, 2019 Category: Cardiology Authors: Li L, Hou X, Geng X, Xu Y Tags: Clin Exp Hypertens Source Type: research

Effects of sleep-disordered breathing and hypertension on cognitive function in elderly adults.
We examined the effects of these two diseases on cognitive function in elderly adults. Methods: Fifty-two elderly individuals (mean age, 69.6 ± 4.0 years) free from impairment in daily living activities participated in this study. Apnea/hypopnea index (AHI) and minimum oxygen saturation (SpO2) were assessed using a portable home monitoring device. We evaluated excessive daytime sleepiness with the Epworth sleepiness scale (ESS). Cognitive performance was assessed using the Wisconsin card sorting test (WCST), continuous performance test-Identical pairs (CPT-IP), and N-back task. Hypertension and diabetes mellitus wer...
Source: Clinical and Experimental Hypertension - July 2, 2019 Category: Cardiology Authors: Kato K, Noda A, Yasuma F, Matsubara Y, Miyata S, Iwamoto K, Miyazaki S, Ozaki N Tags: Clin Exp Hypertens Source Type: research

Berberine reduces endothelial injury and arterial stiffness in spontaneously hypertensive rats.
Conclusions: Abnormal changes of circulating EMPs and EPCs in SHRs are associated with endothelial dysfunction and arterial stiffness. Berberine may be a novel therapeutic option for the hypertension-related vascular injury in SHRs. PMID: 31220947 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - June 20, 2019 Category: Cardiology Authors: Zhang G, Lin X, Shao Y, Su C, Tao J, Liu X Tags: Clin Exp Hypertens Source Type: research

Elevated serum YKL40 level is a predictor of MACE during the long-term follow up in hypertensive patients.
Şatıroğlu Ö Abstract Background: YKL-40 (human cartilage glycoprotein 39, chitinase-3-like protein 1) is an inflammatory marker secreted mainly by macrophages and has distinctive roles on extracellular matrix remodeling, macrophage maturation, adhesion, and migration. Despite the presence of robust data suggesting the association of YKL-40 with variety of cardiovascular diseases (CV), there is no study up to date evaluating the role of YKL-40 on the long-term prognosis in patients with hypertension (HT). Methods: A single center, prospective, observational cohort study that included 327 consecutive hyperte...
Source: Clinical and Experimental Hypertension - June 16, 2019 Category: Cardiology Authors: Çetin M, Erdoğan T, Kırış T, Özer S, Çinier G, Emlek N, Durak H, Şatıroğlu Ö Tags: Clin Exp Hypertens Source Type: research

Tp-e interval, Tp-e/QT and Tp-e/QTc ratio in hypertensive patients with primary aldosteronism.
Abstract Introduction: There is no study evaluating the Tp-e/QT and Tp-e/QTc ratios with T wave peak to end interval (Tp-e interval) used for evaluation of cardiac arrhythmia risk and ventricular repolarization changes in patients with primary aldosteronism (PA). We aimed to investigate whether there was a change in Tp-e interval, Tp-e/QT and Tp-e/QTc ratios in patients with PA. Method: Thirty patients with newly diagnosed hypertension (HT) and PA and 30 patients with primary HT were included. Twelve-lead electrocardiography (ECG) was performed in all patients. Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were measu...
Source: Clinical and Experimental Hypertension - June 15, 2019 Category: Cardiology Authors: Demirtas D, Erdem Sumbul H, Bulut A, Orhan Demirtas A, Gulumsek E, Koca H, Kemal Icen Y, Koc M Tags: Clin Exp Hypertens Source Type: research

Decreased neurotensin levels as a biomarker in resistant hypertension.
Abstract Objective: Although neurotensin is found throughout the body including cardiovascular structures, the correlation of plasma neurotensin levels with resistant hypertension (RH) has never been examined. Therefore, we aimed to compare plasma neurotensin concentration, between patients with RH and those with controlled hypertension (CH). Methods: Forty-one patients with RH and 45 patients with CH who had undergone outpatient ambulatory blood pressure measurements were prospectively recruited. RH was defined as uncontrolled blood pressure despite using three antihypertensive agents including a diuretic or need...
Source: Clinical and Experimental Hypertension - June 15, 2019 Category: Cardiology Authors: Bolat I, Pusuroglu H, Demir AR, Ornek V, Erturk M Tags: Clin Exp Hypertens Source Type: research

Prevalence and contributing risk factors for hypertension in urban and rural areas of Pakistan; a study from second National Diabetes Survey of Pakistan (NDSP) 2016-2017.
Conclusion: This study concludes that 46.2% prevalence of hypertension is alarming in Pakistan with its associated risk factors. Hence, implementation laws with lifestyle changes and educating people are required on urgent basis to control or reduce hypertension prevalence. PMID: 31151358 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - May 31, 2019 Category: Cardiology Authors: Basit A, Tanveer S, Fawwad A, Naeem N, NDSP Members Tags: Clin Exp Hypertens Source Type: research

The relationship between diurnal blood pressure abnormalities and target organ damage in normotensive subjects. Which is more important? Increased blood pressure levels or circadian blood pressure abnormalities.
Conclusions: Our results suggested that normotensive persons with CBP abnormalities had TOD. In light of the data of this article, non-dipper status is detected in the early period and if the provision of diurnal blood pressure rhythm may reduce the incidence of future adverse events in nondipper normotensive subjects. PMID: 31122073 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - May 23, 2019 Category: Cardiology Authors: Kilic A, Baydar O Tags: Clin Exp Hypertens Source Type: research

High-intensity aerobic training lowers blood pressure and modulates the renal renin-angiotensin system in spontaneously hypertensive rats.
This study aimed to verify the effects of high-intensity aerobic training (HIAT) on BP control and renin-angiotensin system (RAS) components in renal tissue of SHR. Ten SHRs received HIAT or control for 8-weeks. At the end of the training, the SBP showed a reduction of ~ 30mmHg (p
Source: Clinical and Experimental Hypertension - May 23, 2019 Category: Cardiology Authors: Almeida JA, Motta-Santos D, Petriz BA, Gomes CPDC, Nogueira ME, Pereira RW, Araújo RC, Prestes J, Franco OL Tags: Clin Exp Hypertens Source Type: research

Characteristics of metabolic factors related to arterial stiffness in young and old adults.
In conclusion, the metabolic biomarkers related to arterial stiffness were different between young and old adults. Contrary to old adults, TC, LDLC, and apolipoprotein B were independent biomarkers for arterial stiffness in healthy young adults. PMID: 31116038 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - May 22, 2019 Category: Cardiology Authors: Won BY, Park SG, Lee SH, Kim MJ, Chun H, Hong D, Kim YS Tags: Clin Exp Hypertens Source Type: research

Declined circulating Elabela levels in patients with essential hypertension and its association with impaired vascular function: A preliminary study.
Conclusion: The present study demonstrates for the first time that circulating ELA levels are reduced in patients with EH. The fall in endogenous ELA levels may be involved in the pathogenesis of hypertension-related vascular damage. PMID: 31116039 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - May 22, 2019 Category: Cardiology Authors: Li Y, Yang X, Ouyang S, He J, Yu B, Lin X, Zhang Q, Tao J Tags: Clin Exp Hypertens Source Type: research

Association between duration of excessive weight and arterial stiffness in middle-aged and older adults.
This study aims to evaluate the association between duration of overweight/obesity and arterial stiffness. In total, 103 men and women aged 45-68 years with a body mass index (BMI) of ≥25 kg/m2 were enrolled in this study. Duration of overweight/obesity was calculated for individuals with at least two consecutive BMI occurrences of ≥25 kg/m2 in the previous (5-year intervals from 20 years old) and present BMI information. Multiple regression analysis showed that carotid-femoral pulse wave velocity, an index of arterial stiffness, was independently associated with the duration of overweight/obesity, but not with curre...
Source: Clinical and Experimental Hypertension - May 20, 2019 Category: Cardiology Authors: Matsui M, Yoshikawa T, Mizushima R, Tanahashi K, Myoenzono K, Tanaka K, Maeda S Tags: Clin Exp Hypertens Source Type: research

The possible role of maternal and placental vitamin D receptor polymorphisms and haplotypes in pathogenesis of preeclampsia.
CONCLUSIONS: the maternal and placental VDR FokI variant was associated with decreased risk of PE in the dominant model. PMID: 31006279 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - April 20, 2019 Category: Cardiology Authors: Farajian-Mashhadi F, Eskandari F, Rezaei M, Eskandari F, Najafi D, Teimoori B, Moradi-Sharbabak M, Salimi S Tags: Clin Exp Hypertens Source Type: research