Seasonal variation of novel arterial stiffness indexes in Japanese hypertensive patients.
Abstract BACKGROUND AND OBJECTIVE: Seasonal variation of blood pressure (BP) is well known, and a relationship between increases in BP and the incidence of cardiovascular accidents (CVAs) in the winter has been reported. Parameters of arterial stiffness may exhibit seasonal variation; however, available data are currently limited. Novel arterial stiffness indexes, namely the arterial velocity pulse index (AVI) and arterial pressure-volume index (API), can be determined through usual maneuver for BP measurement during the regular examination in the outpatient clinic.The present study assessed the seasonal vari...
Source: Clinical and Experimental Hypertension - November 8, 2018 Category: Cardiology Authors: Kita T, Kitamura K Tags: Clin Exp Hypertens Source Type: research

An intron variant in the FLT1 gene increases the risk of preeclampsia in Iranian women.
CONCLUSIONS: Based on our study, rs722503 polymorphism in the FLT1 gene may play an important role in susceptibility to preeclampsia. PMID: 30409050 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 8, 2018 Category: Cardiology Authors: Amin-Beidokhti M, Gholami M, Abedin-Do A, Pirjani R, Sadeghi H, Karamoddin F, Yassaee VR, Mirfakhraie R Tags: Clin Exp Hypertens Source Type: research

Association between handgrip strength and vascular function in patients with hypertension.
Abstract BACKGROUND: Increased handgrip strength has been associated with lower cardiovascular and non-cardiovascular mortality in different populations. In patients with hypertension, arterial stiffness relates to cardiovascular mortality. However, whether muscle strength is associated with arterial stiffness in hypertensives is unknown. Thus, the objective of this study was to analyze the association between handgrip strength and arterial stiffness parameters in hypertensive patients. METHODS: Seventy-two hypertensive patients completed all evaluations and were included in the analysis. The ambulatory arter...
Source: Clinical and Experimental Hypertension - November 8, 2018 Category: Cardiology Authors: Lima-Junior D, Farah BQ, Germano-Soares AH, Andrade-Lima A, Silva GO, Rodrigues SLC, Ritti-Dias R Tags: Clin Exp Hypertens Source Type: research

Assessment of occurrence of preeclampsia and some clinical and demographic risk factors in Zahedan city in 2017.
CONCLUSION: Maternal BMI, maternal hypertension, history of preeclampsia in previous pregnancies, low maternal educational status, and twin or multiple pregnancies might be the risk factors for preeclampsia during pregnancy. PMID: 30388904 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 2, 2018 Category: Cardiology Authors: Farzaneh F, Tavakolikia Z, Soleimanzadeh Mousavi SH Tags: Clin Exp Hypertens Source Type: research

Taekwondo training reduces blood catecholamine levels and arterial stiffness in postmenopausal women with stage-2 hypertension: randomized clinical trial.
Abstract OBJECTIVE: Menopause is associated with a progressive impairment of vascular function and muscular strength in women. Accordingly, the purpose of this study was to determine if Taekwondo training could improve blood catecholamine levels, arterial stiffness, blood pressure (BP) and skeletal muscle strength in postmenopausal women with stage-2 hypertension. METHODS: 20 postmenopausal women (70 ± 4 years old) with stage-2 hypertension were randomly assigned to a 1) Taekwondo training (TT; n = 10) or 2) Control (CON; n = 10) group. Taekwondo training was performe...
Source: Clinical and Experimental Hypertension - November 2, 2018 Category: Cardiology Authors: Lee SH, Scott SD, Pekas EJ, Lee S, Lee SH, Park SY Tags: Clin Exp Hypertens Source Type: research

Multiparameter assessment of exercise capacity in patients with arterial hypertension.
Abstract INTRODUCTION: Arterial hypertension (AH) can lead to the development of heart failure. AIM: Evaluating the relationship between parameters of exercise capacity assessed via a six-minute walk test (6MWT) and cardiopulmonary exercise test (CPET), with a hemodynamic assessment via impedance cardiography (ICG), in patients with AH. METHODS: Exercise capacity was assessed in 98 hypertensive patients (54.5 ± 8.2 years) by means of oxygen uptake (VO2) get from CPET, 6MWT distance (6MWTd) and hemodynamic parameters measured by ICG: heart rate (HR), stroke volume (SV), cardiac outpu...
Source: Clinical and Experimental Hypertension - October 31, 2018 Category: Cardiology Authors: Kurpaska M, Krzesiński P, Gielerak G, Uziębło-Życzkowska B, Banak M, Piotrowicz K, Stańczyk A Tags: Clin Exp Hypertens Source Type: research

Serum total bilirubin concentration is associated with carotid atherosclerosis in patients with prehypertension.
Abstract OBJECTIVES: Bilirubin has been demonstrated to be linked with anti-inflammatory and antioxidant progress. We aimed to evaluate the association between serum total bilirubin level and carotid intima-media thick-ness (cIMT) in patients with prehypertension. METHODS: We consecutively enrolled pre-hypertensive patients from a community in Guangzhou between January 2017 and January 2018. All patients underwent carotid artery ultrasonography measurement. The correlation between serum total bilirubin and cIMT was assessed by using the Pearson's correlation coefficient. Multiple logistic regression analysis ...
Source: Clinical and Experimental Hypertension - October 30, 2018 Category: Cardiology Authors: Tang LH, Huang C, Feng YQ Tags: Clin Exp Hypertens Source Type: research

Short-term outcome and early effect on blood pressure of laparoscopic sleeve gastrectomy in morbidly obese patients.
Abstract Bariatric surgery has been used to reduce weight and shown to be beneficial for hypertension control. However, little is known about the changes in blood pressure in early stage after laparoscopic sleeve gastrectomy (LSG). We conducted a prospective study of 60 LSG patients with one year-follow-up. The blood pressure of the patients was measured preoperatively and from day 1 to 12 months postoperatively. The use of antihypertensives, body weight, ghrelin and leptin levels were also recorded. Following LSG, excess weight loss (EWL) was 72.6 ± 22.3% and 83.1 ± 19.3% 6 ...
Source: Clinical and Experimental Hypertension - October 29, 2018 Category: Cardiology Authors: Yin X, Qian J, Wang Y, Yang C, Jia B, Cheng Y, Yu G, Wang Y Tags: Clin Exp Hypertens Source Type: research

Renal effects of sodium glucose co-transporter 2 inhibitors in Japanese type 2 diabetes mellitus patients with home blood pressure monitoring.
In conclusion, management of blood pressure both at office and home was found to be important for the reno-protective effects of sodium-glucose cotransporter 2 inhibitors along with strict blood pressure management. PMID: 30373408 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 29, 2018 Category: Cardiology Authors: Kobayashi K, Toyoda M, Kimura M, Hatori N, Furuki T, Sakai H, Takihata M, Umezono T, Ito S, Suzuki D, Takeda H, Kanamori A, Degawa H, Yamamoto H, Machimura H, Mokubo A, Chin K, Obana M, Hishiki T, Aoyama K, Nakajima S, Umezawa S, Shimura H, Aoyama T, Sato Tags: Clin Exp Hypertens Source Type: research

A non-synonymous polymorphism in purinergic P2X7 receptor gene confers reduced susceptibility to essential hypertension in Chinese postmenopausal women.
PMID: 30359160 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 25, 2018 Category: Cardiology Authors: Gong C, Liu X, Ding L, Liu Y, Li T, Wang S, Zhao J, Rao S, Xiong C, Yang Y, Liu C, Liang S, Xu H Tags: Clin Exp Hypertens Source Type: research

Relationship of sleep duration on workdays and non-workdays with blood pressure components in Chinese hypertensive patients.
CONCLUSION: Compared with a sleep duration of 5-9 h, longer sleep duration (≥10 h) on workdays and non-workdays was associated with high SBP and PP among Chinese hypertensive adults without antihypertensive treatment. PMID: 30346849 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 22, 2018 Category: Cardiology Authors: Hu L, Huang X, You C, Bao H, Zhou W, Li J, Li P, Wu Y, Wu Q, Wang Z, Gao R, Liang Q, Cheng X Tags: Clin Exp Hypertens Source Type: research

Forecast post-dialysis blood pressure in hemodialysis patients with intradialytic hypertension.
CONCLUSIONS: The chronic inflammation, poor IDWG control, LV diastolic dysfunction, as well as low serum folic acid and magnesium might be associated with increasing prevalence of IDH in MHD patients. Forecasting models for post-HD SBP could help to control hypertension during HD treatments. PMID: 30325241 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 16, 2018 Category: Cardiology Authors: Zou LX, Sun L Tags: Clin Exp Hypertens Source Type: research

TRPV4 activation in rat carotid artery in DOCA hypertension involves eNOS and endothelium-derived contractile factor (EDCF).
CONCLUSION: TRPV4 may regulate the vascular tone of rat carotid artery through an attenuated NO pathway and stimulation of the release of contractile prostanoids in the DOCA hypertensive rats. PMID: 30325243 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 16, 2018 Category: Cardiology Authors: Dash JR, Mishra SK, Parida S, Singh TU, Choudhury S, Muniyappa K Tags: Clin Exp Hypertens Source Type: research

Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension.
CONCLUSION: ARB treatment is a negative risk factor of arterial stiffness in aged patients with essential hypertension. PMID: 30311805 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 12, 2018 Category: Cardiology Authors: Zhu ML, Sun RL, Zhang HY, Zhao FR, Pan GP, Zhang C, Song P, Li P, Xu J, Wang S, Yin YL Tags: Clin Exp Hypertens Source Type: research

Association of the plasma aldosterone concentration, left atrial deformation and ambulatory blood pressure in never-treated early hypertensive patients.
Abstract Left atrial (LA) strain is known to exhibit an early progressive reduction in hypertensive patients with diastolic dysfunction. However, an association of the renin-angiotensin-*aldosterone system (RAAS) with LA deformation has not been found in these patients. We aimed to investigate the association of plasma aldosterone concentration (PAC) and 24-hour ambulatory blood pressure monitoring (ABPM) with LA and left ventricle (LV) deformation in never-treated early hypertensive patients. This cross-sectional study included 101 never-treated subjects who were registered in a working group at The Catholic Univ...
Source: Clinical and Experimental Hypertension - October 12, 2018 Category: Cardiology Authors: Kim GH, Cho JS, Chung WB, Park CS, Ihm SH Tags: Clin Exp Hypertens Source Type: research

Serum concentration of renin-angiotensin system components in association with ACE I/D polymorphism among hypertensive subjects in response to ACE inhibitor therapy.
CONCLUSIONS: Our results suggest that insufficient blood pressure control by ACE-inhibitory therapy could be associated with elevation of serum ACE2 and chymase levels. Also, it appears that ACE I/D polymorphism may influence the circulating quantity of chymase in addition to ACE. PMID: 30307755 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 11, 2018 Category: Cardiology Authors: Hristova M, Stanilova S, Miteva L Tags: Clin Exp Hypertens Source Type: research

Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5.
Abstract The incidence of hypertension and diabetes is increasing, it is reported that adipocytokines might be involved in the pathogenesis of diabetes and hypertension. We aimed to investigate the features of adipocytokines, included of Leptin, Irisin, LGR4, and Sfrp5 in type 2 diabetes mellitus (T2DM) patients with hypertension, simultaneously analyzed the connection of the alteration of adipocytokines with blood pressure and glucose. 424 patients with T2DM and 90 healthy subjects were included in the study. The patients with T2DM were divided into 4 groups based on the blood pressure. The levels of adipocytokin...
Source: Clinical and Experimental Hypertension - October 11, 2018 Category: Cardiology Authors: Li B, Yao Q, Guo S, Ma S, Dong Y, Xin H, Wang H, Liu L, Chang W, Zhang Y Tags: Clin Exp Hypertens Source Type: research

Predictive value of long noncoding RNA ZFAS1 in patients with ischemic stroke.
Abstract BACKGROUND: LncRNAs play an essential role in a variety of diseases. Zinc finger antisense 1 (ZFAS1), a newly identified lncRNA, is a transcript antisense to the 5' end of the gene Znfx1. The purpose of this study was to aim to compare the levels of ZFAS1 between ischemic stroke (IS) and healthy control subjects and explore its potential role as a noninvasive biomarker in the diagnosis of IS. METHODS:  A total of 176 patients and 111 healthy controls were included in the study. RT-qPCR was performed to detect the expression of ZFAS1. RESULTS: The results showed that level of ZFAS1 in IS pat...
Source: Clinical and Experimental Hypertension - October 11, 2018 Category: Cardiology Authors: Wang J, Ruan J, Zhu M, Yang J, Du S, Xu P, Zhang Z, Wang P, Yang W, Yu M Tags: Clin Exp Hypertens Source Type: research

Risk of high blood pressure associated with objective insomnia and self-reported insomnia complaints in major depression: A study on 703 individuals.
CONCLUSION: In major depression, severe objective insomnia and lower self-reported insomnia complaints are associated with higher risk of high blood pressure, which justifies a better management of objective insomnia and a better assessment of insomnia complaints in this particular subpopulation to avoid the negative consequences related to the co-occurrence of high blood pressure and major depression. ABBREVIATIONS: AHI, Apnea-Hypopnea Index; BDI, Beck Depression Inventory; BMI, Body Mass Index; DSM IV-TR, Diagnostic and Statistical Manual of Mental Disorders fourth edition - Text Revision; ESS, Epworth Sleepiness sc...
Source: Clinical and Experimental Hypertension - October 10, 2018 Category: Cardiology Authors: Hein M, Lanquart JP, Loas G, Hubain P, Linkowski P Tags: Clin Exp Hypertens Source Type: research

A risk prediction model for renal damage in a hypertensive Chinese Han population.
Abstract Backgroud: While numerous risk factors for renal damage in the hypertensive population have been reported, there is no single prediction model. The purpose of this study was to develop a model to comprehensively evaluate renal damage risk among hypertensive patients. Methods: We analyzed the data of 582 Chinese hypertensive patients from 1 January 2013 to 30 June 2016. Basic patient information was collected along with laboratory test results. According to the albumin-to-creatinine ratio, the subjects were divided into a hypertension with renal damage group and a hypertension without r...
Source: Clinical and Experimental Hypertension - October 9, 2018 Category: Cardiology Authors: Lin J, Xu R, Yun L, Hou Y, Li C, Lian Y, Zheng F Tags: Clin Exp Hypertens Source Type: research

Renal resistive index significantly increased in hypertensive children and it is independently related to the pulse pressure and left ventricular mass index.
In this study, we aimed to investigate the changes of RRI values and it is usability in children with HT. METHODS: A total of 75 children; 48 with newly diagnosed HT and 27 healthy controls were included in the study. Routine history, physical examination, and laboratory examinations were performed. Left ventricular (LV) dimensions and systolic-diastolic functions, septum and posterior wall thickness (IVSd and PWd) and LV mass index (LVMI) were calculated by echocardiography. In addition to routine renal ultrasonography (US), renal pulsatility indexes (RPI), accelerated time and RRI were measured. Increased RRI was ac...
Source: Clinical and Experimental Hypertension - October 4, 2018 Category: Cardiology Authors: Cilsal E, Koc AS Tags: Clin Exp Hypertens Source Type: research

Hypertensive emergencies in diabetic patients from predominantly African American urban communities.
CONCLUSION: The development of hypertensive emergencies in patients with diabetes was not because of diabetes per se but because of coexisting highly elevated blood pressure. Tight blood pressure control may decrease the risk of hypertensive emergencies in this patient population. PMID: 30285508 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 4, 2018 Category: Cardiology Authors: Benenson I, Waldron FA, Jones Dillon SA, Zinzuwadia SN, Mbadugha N, Vicente N, Aris E, Adeboye AM, Makdisi C Tags: Clin Exp Hypertens Source Type: research

Relationship between the NF- κB1-94ins/del ATTG locus polymorphism and risk of hypertension in the Chinese Han population.
Relationship between the NF-κB1-94ins/del ATTG locus polymorphism and risk of hypertension in the Chinese Han population. Clin Exp Hypertens. 2018 Oct 04;:1-6 Authors: Chen J, Ge D, Xiong Y Abstract OBJECTIVE: The onset of essential hypertension is the result of a combination of genetic factors and the environment. The nuclear factor (NF)-κB1-94ins/del ATTG locus polymorphism is associated with the occurrence of various diseases. The purpose of this study was to find out the relationship between the NF-κB1-94ins/del ATTG locus polymorphism and the risk of hypertension in the Chinese ...
Source: Clinical and Experimental Hypertension - October 4, 2018 Category: Cardiology Authors: Chen J, Ge D, Xiong Y Tags: Clin Exp Hypertens Source Type: research

Induced carotid atherosclerosis in lupus mice.
Abstract Fas knockout (Fas-/-) mice are a model for systemic lupus erythematosus (SLE) -like autoimmune syndromes. We aimed to induce atherosclerosis (AS) in Fas-/- mice. Sixteen male Fas-/- mice were included in the study, sex-matched C57B6/L (B6) and apolipoprotein E-knockout (ApoE-/-) mice were negative and positive AS controls, respectively. A silica collar was placed around the right carotid artery of each mouse to induce AS development. All mice were fed a 24-week high-fat diet, and investigated for AS lesions. We also compared the levels of blood lipid and glucose, serum tumor necrosis factor α (TNF-&...
Source: Clinical and Experimental Hypertension - September 20, 2018 Category: Cardiology Authors: Wang Y, Huang Z, Lin L, Huang G, Liu W, Xue Y Tags: Clin Exp Hypertens Source Type: research

Left ventricular hypertrophy is associated with increased sirtuin level in newly diagnosed hypertensive patients.
The objective of this study was to evaluate the relation of serum SIRT1 level with left ventricular hypertrophy (LVH) in newly diagnosed hypertensive patients. METHODS: One hundered and twenty-five consecutive, newly diagnosed hypertensive patients were divided into two groups with regard to presence of LVH and compared to 40 healthy control subjects. LVH was determined by transthoracic echocardiography using the cube formula. Serum SIRT1 level was analyzed with enzyme-linked immunosorbent assay. RESULTS: Serum SIRT1 level was significantly higher in patients with LVH compared to those without LVH (14.3 &plu...
Source: Clinical and Experimental Hypertension - September 19, 2018 Category: Cardiology Authors: Duman H, Bahçeci I, Çinier G, Duman H, Bakırcı EM, Çetin M Tags: Clin Exp Hypertens Source Type: research

Liberating carotid arteries: measuring arterial pressure through femoral artery in mice.
This study was aimed to evaluate whether femoral artery could displace carotid artery for the blood pressure (BP) measurements in mice. Fifty-six Swiss mice (n = 14 in each group) were randomized into four groups: control, left femoral artery, right femoral artery, and union group, in which BP was measured through left carotid, left femoral, right femoral artery, and simultaneously from right femoral artery and left carotid artery, respectively. Arterial pressure was recorded for 5 min after catheterization. There was no significant difference of the success rate and mortality rate among four groups (P&...
Source: Clinical and Experimental Hypertension - September 10, 2018 Category: Cardiology Authors: Wu L, Lin W, Fu X, Li X, Li X, Li Y, Zhang W, Guo J, Gao Q Tags: Clin Exp Hypertens Source Type: research

Smoking and hypertension: Effect of adenosine deaminase polymorphism.
Abstract Adenosine modulates cardiovascular functions reducing blood pressure and heart rate. Adenosine deaminase (ADA) by the irreversible deamination of adenosine to inosine contributes to the regulation of adenosine concentration in body fluids. We have studied the interaction between smoking and ADA genetic variability concerning their effects on blood pressure. We have studied 344 subjects admitted to the hospital for cardiovascular diseases. The genotypes of two polymorphic loci within the ADA gene were determined: ADA1 and ADA2. Both loci show two alleles: ADA1*1 and ADA1*2 in ADA1 locus and ADA2*1 and...
Source: Clinical and Experimental Hypertension - September 7, 2018 Category: Cardiology Authors: Gloria-Bottini F, Banci M, Neri A, Magrini A, Bottini E Tags: Clin Exp Hypertens Source Type: research

Pitavastatin ameliorates myocardial damage by preventing inflammation and collagen deposition via reduced free radical generation in isoproterenol-induced cardiomyopathy.
Abstract Pitavastatin inhibits 3 hydroxy 3 methyl glutaryl coenzyme A (HMGCoA) reductase enzyme, preventing cholesterol synthesis along with elevating high density apolipoprotein A1 (Apo-A1). The present study was designed to evaluate cardioprotective potential of pitavastatin at 1 mg/kg/day and 3 mg/kg/day dose for 14 days in low dose isoproterenol (ISO) (5 mg/kg/day for 7 consecutive days) induced myocardial damage. ISO administration induced significant reduction in endogenous antioxidant enzymes like reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and raised thiobarbituric acid reactive s...
Source: Clinical and Experimental Hypertension - September 7, 2018 Category: Cardiology Authors: Iqbal R, Akhtar MS, Hassan MQ, Jairajpuri Z, Akhtar M, Najmi AK Tags: Clin Exp Hypertens Source Type: research

Associations of genetic polymorphisms of the vitamin D pathway with blood pressure in a Han Chinese population.
Abstract Vitamin D deficiency can lead to high blood pressure. Polymorphisms in the vitamin D hydroxylase gene have been associated with serum vitamin D levels in some Western countries. The aim of this study was to investigate whether polymorphisms of hydroxylase genes in the vitamin D metabolic pathway contribute to hypertension by affecting serum vitamin D status in a Han Chinese population. We selected four single nucleotide polymorphisms (SNPs; rs1993116 and rs10741657 of CYP2R1; rs4809957 and rs6068816 of CYP24A1) for genotyping in 525 control subjects and 324 hypertensive patients, and detected vitamin D le...
Source: Clinical and Experimental Hypertension - September 7, 2018 Category: Cardiology Authors: Ye X, Jia J, Zhang N, Ding H, Zhan Y Tags: Clin Exp Hypertens Source Type: research

Wet cupping for hypertension: a systematic review and meta-analysis.
Abstract To assess the efficacy and safety of wet cupping in adults with hypertension, we conducted a systematic review and meta-analysis using 13 databases. Wet cupping alone or in combination with antihypertensive medication or acupuncture was used. Seven randomized trials were included, most not of high methodological quality. A few small studies suggested that wet cupping alone versus antihypertensive medication significantly reduced blood pressure and Traditional Chinese Medicine syndrome (hypertension-related symptoms). However based on current evidence, no firm conclusions can be drawn and no clinical recom...
Source: Clinical and Experimental Hypertension - September 5, 2018 Category: Cardiology Authors: Lu S, Du S, Fish A, Tang C, Lou Q, Zhang X Tags: Clin Exp Hypertens Source Type: research

Effects of vitamin C supplementation on blood pressure and hypertension control in response to ambient temperature changes in patients with essential hypertension.
In this study, eligible patients were cluster assigned to receive 300 mg VC per day or nothing for 6 months. During the 6-month follow-up period, a questionnaire survey was obtained and standardized blood pressure measurements were performed on all subjects. Oral administration of VC significantly decreased the diastolic blood pressure and pulse pressure with a significant increase in HTN control. After adjusting for confounding variables, treatment with VC was associated with ~ 0.5 risk reduction of uncontrolled HTN in subjects received anti-hypertensive medications, whereas lower indoor and outdoor and gro...
Source: Clinical and Experimental Hypertension - September 5, 2018 Category: Cardiology Authors: Yuan X, Li X, Ji Z, Xiao J, Zhang L, Zhang W, Su H, Kaliannan K, Long Y, Shao Z Tags: Clin Exp Hypertens Source Type: research

Ferulic acid ameliorated placental inflammation and apoptosis in rat with preeclampsia.
Abstract Preeclampsia (PE) occurs specifically during pregnancy characterized by new-onset hypertension. The pathogenesis of PE was complicated, and inflammation may be central to the pathogenesis of PE. Ferulic acid (FA) is recognized to prevent cell damage and apoptosis induced by oxidative stress and inflammation. In our study, we used NG-nitro-l-arginine methyl ester (L-NAME)-induced rat model of PE to investigate whether FA improved PE and its possible mechanism. We found that FA significantly reduced blood pressure, urine volume, and urinary protein level in rats with PE. Meanwhile, FA decreased L-NAME induc...
Source: Clinical and Experimental Hypertension - September 5, 2018 Category: Cardiology Authors: Chen Y, Xue F, Han C, Yang H, Han L, Li K, Li J, Xu Q, Li Z, Yuan B, Yu L, Gao X, Yan Y Tags: Clin Exp Hypertens Source Type: research

Resistant hypertension in elderly: a clinical manifestation of heart failure with preserved ejection fraction? retrospective single-center analysis.
Abstract BACKGROUND: Resistant hypertension (RHT) is defined as high blood pressure despite three antihypertensive medications one being a diuretic. RHT is a common clinical problem and as a subgroup has not been studied widely. The present study has investigated patient demographics and if the RHT might be a clinical presentation of heart failure with preserved ejection fraction (HFPEF) in elderly. METHOD: The outpatient data between January and June 2015 of Izmir Kemalpasa State hospital's hypertension specialty clinic has been reviewed retrospectively. The patients with pseudo-RHT are excluded. Among 957 p...
Source: Clinical and Experimental Hypertension - September 5, 2018 Category: Cardiology Authors: Turkoglu EI, Kircicegi Cıcekdag EC Tags: Clin Exp Hypertens Source Type: research

MTHFD1 promoter hypermethylation increases the risk of hypertension.
This study aimed to investigate the association of MTHFD1 promoter methylation with essential hypertension. METHODS: Using the quantitative methylation-specific polymerase chain reaction (qMSP), the levels of MTHFD1 promoter methylation in 243 essential hypertension patients, 218 age- and gender-matched healthy controls. The relative changes in serum MTHFD1 promoter methylation were analyzed using the 2-ΔΔCt method. The percent of methylated reference (PMR) of MTHFD1 was used to evaluate the MTHFD1 promoter methylation levels. RESULTS: In our current study, the MTHFD1 promoter methylation of hypertens...
Source: Clinical and Experimental Hypertension - September 5, 2018 Category: Cardiology Authors: Xu M, Li J, Chen X, Han L, Li L, Liu Y Tags: Clin Exp Hypertens Source Type: research

Clinical pertinence of neutrophil-to- lymphocyte ratio among hypertensives with different grades and duration of hypertension - an insight.
This study correlates the same specifically taking into account the duration and the grades of hypertension. OBJECTIVE: The response of the NLR among the hypertensives and its correlation with duration and stages of hypertension. METHOD: Totally, 80 subjects and 40 controls of age between 20 and 60 years and both genders were included. Three recordings of blood pressure were measured with a standard mercury sphygmomanometer. The differential leukocyte count was estimated with an automated Beckman Coulter. OBJECTIVE: Variations in the neutrophil and lymphocyte counts were significant among the hyper...
Source: Clinical and Experimental Hypertension - September 5, 2018 Category: Cardiology Authors: Srinivasagopalane B, Andrew Rajarathinam S, Balasubramaiyan T Tags: Clin Exp Hypertens Source Type: research

Platelet microparticles-containing miR-4306 inhibits human monocyte-derived macrophages migration through VEGFA/ERK1/2/NF- κB signaling pathways.
In conclusion, our study suggested that intercellular transfer of miR-4306 by platelet microparticles inhibited the HMDMs migration through VEGFA/ERK1/2/NF-κB signaling pathways. PMID: 30183452 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - September 5, 2018 Category: Cardiology Authors: Yang Y, Luo H, Liu S, Zhang R, Zhu X, Liu M, Hu H, Yang Y, Lv Z, Chen M Tags: Clin Exp Hypertens Source Type: research

Gender difference in the relationship between uric acid and pulse pressure among Korean adults.
In conclusion, uric acid was positively associated with pulse pressure in women, but not in men. PMID: 30141972 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 24, 2018 Category: Cardiology Authors: Park CE, Sung HH, Jung EY, Moon AE, Kim HS, Yoon H Tags: Clin Exp Hypertens Source Type: research

Increased carotid-femoral pulse wave velocity and common carotid artery intima-media thickness obtained to assess target organ damage in hypertensive patients are closely related.
CONCLUSION: There is a close relationship between CC-IMT and CF-PWV increase in HT. It was thought that it would still be more useful to look at the increase of CC-IMT compared to other vascular regions for screening asymptomatic organ damage. PMID: 30141974 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 24, 2018 Category: Cardiology Authors: Sumbul HE, Koc AS, Demirtas D Tags: Clin Exp Hypertens Source Type: research

Acute effects of walking in water on vascular endothelial function and heart rate variability in healthy young men.
Abstract AIM: Aquatic exercise might improve endothelial function due to hydrostatic pressure increasing blood flow and causing shear stress to the endothelium. However, the acute effect of aerobic exercise in water on endothelial function is unclear. The present study compares the acute effect of aerobic exercise at moderate intensity in water and on land on endothelial function. METHODS: Nine healthy young men walked on a treadmill for 30 min while immersed in water up to the xiphoid at 30.0 ± 0.2°C and on land at an intensity equivalent to 60% heart rate reserve in a crossover tri...
Source: Clinical and Experimental Hypertension - August 24, 2018 Category: Cardiology Authors: Hashimoto Y, Okamoto T Tags: Clin Exp Hypertens Source Type: research

Therapeutic potentials of propolis and pollen on biochemical changes in reproductive function of L-NAME induced hypertensive male rats.
Abstract BACKGROUND: Hypertension is described as increased blood pressure based on changed hemodynamics and associated with an increased oxidative damage to reproductive function. This work is to determine therapeutic and protective effects of apitherapy products (propolis and pollen) on reproductive functions of L-NAME-induced hypertensive male rats. METHODS: Experimental animals were indiscriminately separated into four groups of seven rats in each group: (I) Control, (II) L-NAME, (III) L-NAME+ propolis and (IV) L-NAME+ pollen. At the end of the experimental applications, the rats were decapitate...
Source: Clinical and Experimental Hypertension - August 17, 2018 Category: Cardiology Authors: Gulhan MF Tags: Clin Exp Hypertens Source Type: research

Analysis and identification of symptoms and risk factors in a cohort of chronic hypertensive patients in a tertiary care hospital in Sri Lanka.
CONCLUSION: Symptoms of those with HT are mostly nonspecific and should be considered as possible warning signs prior to the development of sinister complications of the disease. Family history of HT with affected siblings, or one of the parents, was, observed in more than one-third of patients. Early screening and prevention of modifiable risk factors are important in these patients to prevent debilitating complications. PMID: 30111179 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 15, 2018 Category: Cardiology Authors: Ralapanawa U, Nanayakkara N, Jayawickreme KP, Wickramasurendra N, Tennakoon S Tags: Clin Exp Hypertens Source Type: research

The association between obesity indices and hypertension: Which index is the most notable indicator of hypertension in different age groups stratified by sex?
CONCLUSIONS: In this Chinese population, the association of obesity indices and hypertension is inconsistent in different age groups and sexes. It is important to choose appropriate indicators for specific groups of people. PMID: 30095294 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 10, 2018 Category: Cardiology Authors: Wu X, Li B, Lin WQ, Huang LL, Wang XX, Fu LY, Li BB, Wang PX Tags: Clin Exp Hypertens Source Type: research

The association of smoking and hypertension according to cotinine-verified smoking status in 25,150 Korean adults.
CONCLUSION: This large observational study found that smoking was not associated with hypertension in the overall population, but, when the gender was considered, female smokers were more likely to demonstrate hypertension. PMID: 30059635 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - July 30, 2018 Category: Cardiology Authors: Kim SH, Lee JS Tags: Clin Exp Hypertens Source Type: research

Effects of SSRI medication on heart rate and blood pressure in individuals with hypertension and depression.
CONCLUSION: Escitalopram decreases HR, but not BP, in individuals with hypertension and depression. Abbreviation: SH: systemic hypertension; BP: blood pressure; DSM: Diagnostic and Statistical Manual of Mental Disorders; SRQ 20: Self-Report Questionnaire; SCID: Structured Clinical Interview for DSM-IV; HR: heart rate; SNS: Sympathetic nervous system; HPA: hypothalamus-pituitary-adrenal axis; RAA: renin, angiotensin, aldosterone system; NE: norepinephrine; CSF: cerebrospinal fluid; HAM-D: Hamilton Depression Rating Scale; CRF: corticotropin releasing factor; ACTH: adrenocorticotropic hormone; BMI: Body mass index; SBP: syst...
Source: Clinical and Experimental Hypertension - July 26, 2018 Category: Cardiology Authors: Peixoto MF, Cesaretti M, Hood SD, Tavares A Tags: Clin Exp Hypertens Source Type: research

Trimethylamine-N-oxide (TMAO) increased aquaporin-2 expression in spontaneously hypertensive rats.
Abstract Recent evidence suggests that elevated plasma levels of Trimethylamine-N-oxide (TMAO) can prolong the duration of elevated blood pressure in rats. The purpose of this study was to investigate the plasma TMAO level in Spontaneously Hypertensive Rats (SHR) and to explore the possible relationship between TMAO and aquaporin-2 (AQP-2) in the formation of hypertension. Twelve-week-old, male Spontaneously Hypertensive rats (SHR, n = 40) and Wistar-Kyoto rats (WKY, n = 40) were accordingly grouped into SHR group and WKY group. Each group was divided randomly into four subgroups: Untreated group, TMAO group, TMAO...
Source: Clinical and Experimental Hypertension - July 9, 2018 Category: Cardiology Authors: Liu M, Han Q, Yang J Tags: Clin Exp Hypertens Source Type: research

The effect of hypertension on cardiac structure and function in different types of hypertrophic cardiomyopathy: A single-center retrospective study.
CONCLUSIONS: HTN can affect left ventricular capacity in obstructive HCM and apical HCM, causing a decrease in ventricular capacity in the former and increase in the latter; it has no significant effect on the size of the left ventricular cavity in septal HCM. HTN can lead to a poor therapeutic effect on aortic flow rate and pressure gradient in obstructive HCM patients. PMID: 29985667 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - July 9, 2018 Category: Cardiology Authors: Deng T, Ou B, Zhu T, Xu D Tags: Clin Exp Hypertens Source Type: research

Recommended standards for assessing blood pressure in human research where blood pressure or hypertension is a major focus.
CONCLUSIONS: All new research should require adherence to these minimum standards on the patient populations described above. Readers need to use caution in interpreting studies if the standards are not met in the defined populations. PMID: 29953266 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - June 28, 2018 Category: Cardiology Authors: Consortium T Tags: Clin Exp Hypertens Source Type: research

Genetic screening for Bartter syndrome and Gitelman syndrome pathogenic genes among individuals with hypertension and hypokalemia.
CONCLUSIONS: This is the first study performing combined genetic screening for BS and GS pathogenic genes among individuals with unexplained hypertension and hypokalemia. Our data suggested that BS or GS may contribute to the etiology of patients presented with hypertension and hypokalemia. Genetic testing for BS and GS pathogenic genes are recommended to facilitate precision diagnoses and targeted treatment. PMID: 29953267 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - June 28, 2018 Category: Cardiology Authors: Bao M, Cai J, Yang X, Ma W Tags: Clin Exp Hypertens Source Type: research

A comparison of the cutaneous microvascular properties of the Spontaneously Hypertensive and the Wistar-Kyoto rats by Spectral analysis of Laser Doppler.
Abstract This work was aimed to study skin blood perfusion, vasomotion and vascular responses of the Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) in different stages of age using spectral. Laser-Doppler flowmetry (LDF) was used to examine the ears and limbs of WKY (12 and 48 weeks old) and SHR (12 and 48 weeks old). The skin blood flow oscillations (SBFOs) were studied by wavelet spectral analysis of LDF tracings. Then, we observed that old groups showed decreased perfusion and SBFO in the ears of both SHR and WKY. The SHR showed obviously lower postocclusive reactive hypera (PORH) ratio at th...
Source: Clinical and Experimental Hypertension - June 25, 2018 Category: Cardiology Authors: Yuan X, Wu Q, Shang F, Li B, Liu M, Wang B, Sheng Y, Zhang H, Xiu R Tags: Clin Exp Hypertens Source Type: research

Differences in the treatment and control of hypertension in urban and rural residents of the northeastern region of the People's Republic of China: a cross-sectional study.
CONCLUSION: Treatment and control rates of hypertension in urban and rural areas were lower than the national average; blood pressure control in patients taking antihypertensive drugs needs further improvement. PMID: 29939765 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - June 25, 2018 Category: Cardiology Authors: Zhao L, Sun W, Wang J, Wu J, Zhang Y, Liu Y, Liu B Tags: Clin Exp Hypertens Source Type: research