The present situation of home blood pressure measurement among outpatients in Japan.
CONCLUSIONS: Our findings suggest that physicians should recommend measuring HBP in accordance with the Japanese Society of Hypertension guidelines more aggressively, and provide more detailed explanations to patients regarding how to measure HBP. PMID: 30760048 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - February 13, 2019 Category: Cardiology Authors: Noda A, Obara T, Abe S, Yoshimachi S, Satoh M, Ishikuro M, Hara A, Metoki H, Mano N, Ohkubo T, Goto T, Imai Y Tags: Clin Exp Hypertens Source Type: research

Chronobiological characteristics of locomotor activity in congenic rats (SHRSPwch1.0) and their effects on arterial pressure.
PMID: 30724620 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - February 6, 2019 Category: Cardiology Authors: Kawamura H, Mitsubayashi H, Ikeda K, Kawakami K, Nabika T Tags: Clin Exp Hypertens Source Type: research

A potential risk factor of essential hypertension in case-control study: MicroRNAs miR-10a-5p.
Abstract BACKGROUND: Essential hypertension is a multifactorial disease with high morbidity. The researches on the influence of genes on the disease are still in its infancy, and the mechanism of gene regulation is not clear. MiRNAs are key molecules that regulate the expression control of protein-coding or protein-non-coding RNA. It may be an important biological molecule risk factor for essential hypertension. METHODS: A case-control study with 98 EH and 98 non-EH was conducted in our experiment. The candidate miRNAs including miR-10a-5p and miR-497-5p were detected and verified by qRT-PCR. RESULTS: Th...
Source: Clinical and Experimental Hypertension - February 1, 2019 Category: Cardiology Authors: Luo Y, Bao X, Zheng S, Gu T, Mao S, Liu S, Sun J, Huang M, Zhang L Tags: Clin Exp Hypertens Source Type: research

Serum uric acid concentration is associated with ascending aortic dilatation in newly diagnosed nondiabetic hypertensive patients.
Abstract OBJECTIVES: Recently, serum uric acid (UA) has emerged as an important independent risk factor for adverse outcomes in hypertension. The aim of the study was to evaluate the relationship between UA levels and ascending aortic dilatation (AAD) in newly diagnosed nondiabetic hypertensive subjects. METHODS: A total of 818 patients with a new diagnosis of hypertension for which they had never received treatment were enrolled in this cross-sectional study. All patients underwent comprehensive transthoracic echocardiography measurement. AAD was defined as a diameter of ascending aorta equal to or more than...
Source: Clinical and Experimental Hypertension - January 31, 2019 Category: Cardiology Authors: Li WF, Huang YQ, Feng YQ Tags: Clin Exp Hypertens Source Type: research

In-utero cold stress causes elevation of blood pressure via impaired vascular dopamine D1 receptor in offspring.
CONCLUSION: The results illustrate a new paradigm for the developmental origins of hypertension and imply that GRK4 and dopamine D1 receptor may be crucial determinants for the maternal hypertension. PMID: 30698033 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - January 30, 2019 Category: Cardiology Authors: Sun D, Chen K, Wang J, Zhou L, Zeng C Tags: Clin Exp Hypertens Source Type: research

Left atrial volume index is superior to left atrial diameter index in relation to coronary heart disease in hypertension patients with preserved left ventricular ejection fraction.
Abstract OBJECTIVE: Research hypothesis is that left atrial (LA) volume index is superior to LA diameter index for coronary heart disease and LA volume index is important to refine risk stratification. METHODS: We retrospectively enrolled 222 asymptomatic non-ischemic patients with hypertension who had stored digital images in 2012. Patients were followed up for coronary heart disease over a median of 3.2 years. The Area under receiver operating characteristic curve for LA parameters with coronary heart disease was evaluated. Cox regression was used to assess the association between left atrial parameter...
Source: Clinical and Experimental Hypertension - January 30, 2019 Category: Cardiology Authors: Fu M, Zhou D, Tang S, Zhou Y, Feng Y, Geng Q Tags: Clin Exp Hypertens Source Type: research

Evaluation of platelet distribution width in hypertension with hyperhomocysteinemia.
The objective of this study was to evaluate the association between the PDW and hypertension with hyperhomocysteinemia in an elderly cohort. We performed a cross-sectional analysis among 2,685 elderly individuals who underwent hematological testing and blood pressure assessment. Individuals were divided according to the PDW quartiles. An unconditional multiple logistic regression analysis was used to determine the association between PDW and hypertension with hyperhomocysteinemia, after adjustments for gender, age, drinking status, creatinine levels, glucose levels, uric acid levels, triglyceride levels, platelet counts an...
Source: Clinical and Experimental Hypertension - January 28, 2019 Category: Cardiology Authors: Li G, Zhang Y, Zhu Z, Du J Tags: Clin Exp Hypertens Source Type: research

Editorial retraction.
EDITORIAL RETRACTION. Clin Exp Hypertens. 2019 Jan 24;:1 Authors: PMID: 30676090 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - January 24, 2019 Category: Cardiology Tags: Clin Exp Hypertens Source Type: research

Standardized ethanol-water extract of Ficus deltoidea Angustifolia reduces blood pressure in spontaneously hypertensive rats.
This study, therefore, investigated the effects of a standardized ethanolic-water extract of Ficus deltoidea Angustifolia (FD-A) on blood pressure (BP) in spontaneously hypertensive rats (SHR). Male SHR with systolic BP of>150 were divided into 4 groups (n = 8) and given either FD-A (800 or 1000 mg kg-1 day-1) or losartan (10 mg kg-1 day-1) or 0.5 ml of distilled water (control) daily for 28 days. BP, body weight, food and water intake, serum and urinary electrolytes, endothelin-1 (ET-1), total antioxidant capacity (TAC) and components of the renin-angiotensin-aldosterone system were measur...
Source: Clinical and Experimental Hypertension - January 16, 2019 Category: Cardiology Authors: Kamal MSA, Ismail NH, Satar NA, Azis NA, Radjeni Z, Mohammad Noor HS, Kasim N, Singh H Tags: Clin Exp Hypertens Source Type: research

Maximum home systolic blood pressure is a marker of carotid atherosclerosis.
Abstract BACKGROUND: Maximum home systolic blood pressure (maximum SBP) has been reported as a parameter of blood pressure (BP) variability. We tested the hypothesis that maximum SBP is one of the risk factors of hypertensive target organ damage (TOD). METHODS: We conducted a cross-sectional study of 4,310 subjects with 1 cardiovascular risk factor. The subjects measured their home BP for 14 consecutive days. Mean and maximum SBPs were used as independent variables. As dependent variables, we used left ventricular mass index (LVMI), brachial-ankle pulse wave velocity (baPWV), maximum carotid intima-media thic...
Source: Clinical and Experimental Hypertension - January 11, 2019 Category: Cardiology Authors: Kaihara T, Hoshide S, Tomitani N, Kanegae H, Kario K, J-HOP Study Group Tags: Clin Exp Hypertens Source Type: research

Vascular effects of isometric handgrip training in hypertensives.
Abstract The isometric handgrip training (IHT) has been emerging as an alternative approach for blood pressure (BP) reduction in hypertensive patients. However, the mechanisms underlying the reductions in BP after IHT are poorly known. Thus, the aim of this study was to analyze the vascular effects of IHT in hypertensive patients. A randomized controlled trial was conducted with 33 hypertensive patients (61 ± 2 y.o.; 67% female) who were randomly assigned to two groups: IHT or control group. The IHT group has completed three weekly sessions of isometric handgrip (4 × 2  min ...
Source: Clinical and Experimental Hypertension - January 9, 2019 Category: Cardiology Authors: Cahu Rodrigues SL, Farah BQ, Silva G, Correia M, Pedrosa R, Vianna L, Ritti-Dias RM Tags: Clin Exp Hypertens Source Type: research

Irreversible effects of long-term chronic smoking on arterial stiffness: An analysis focusing on ex-smokers among otherwise healthy middle-aged men.
Abstract OBJECTIVE: Smoking is a modifiable cardiovascular risk factor closely related to arterial stiffness (AS). However, data are lacking regarding the chronic effects of smoking on AS, especially in ex-smoker (ES) who faces remnant cardiovascular risk when compared to never-smokers (NS). METHODS: Among 1722 health screening participants, we retrospectively evaluated 652 healthy men with different smoking history [240 current smoker (CS) vs. 228 ES vs. 184 NS]. To assess AS, augmentation index (AIx), pulse pressure amplification (PPamp), and carotid-femoral pulse wave velocity (cfPWV) were measured and com...
Source: Clinical and Experimental Hypertension - December 23, 2018 Category: Cardiology Authors: Kim S, Lee SJ, Kim YH, Kim JS, Lim SY, Kim SH, Ahn JC, Song WH, Jee SH, Park CG Tags: Clin Exp Hypertens Source Type: research

Prospective single-arm observational study of human chymase inhibitor Polygonum hydropiper L in subjects with hypertension.
Abstract BACKGROUND AND PURPOSE: Human chymase (h-chymase) is a serine protease that forms local angiotensin II and has been proven to be related to onset of hypertension, arteriosclerosis, and post myocardial infarction cardiac remodeling. Since no chymase inhibitor was clinically available, an extensive screening for inhibition of h-chymase in three different extracts (water, hot water,  and ethanol) of approximately 800 food ingredients had been performed and we identified Polygonum hydropiper L (Polygonum). Using a dried and powdered Polygonum, we conducted a prospective, single-arm, pilot study to invest...
Source: Clinical and Experimental Hypertension - December 23, 2018 Category: Cardiology Authors: Okamura K, Kuroda R, Nagata K, Urata H Tags: Clin Exp Hypertens Source Type: research

Plasma leptin level is positively associated with blood pressure measures independent of gender and BMI.
Abstract BACKGROUND: Since the introduction of leptin, many studies suggest an important role for this hormone in obesity-related hypertension. However, in non-obese patients, there are controversial results regarding the possible role of leptin in essential hypertension especially in both sexes and different groups of body mass index (BMI). We aimed to evaluate the association of leptin and hypertension in both female and male gender. MATERIALS AND METHODS: This cross-sectional study was conducted, recruiting 80 essential hypertensive patients and 80 healthy normotensive volunteers using convenience sampling...
Source: Clinical and Experimental Hypertension - December 22, 2018 Category: Cardiology Authors: Ghaedian MM, Nazari Jaz A, Momeni M, Ghaedian T, Samiei N Tags: Clin Exp Hypertens Source Type: research

Prevalence and factors associated with fast resting heart rate in hypertensive and normotensive patients.
Abstract BACKGROUND: Fast resting heart rate (RHR) is easily neglected in clinical practice of hypertension treatment. AIMS: We aimed to investigate the prevalence of fast RHR and associated factors in hypertensive and normotensive individuals. METHODS: We retrospectively analyzed data from two cross-sectional studies conducted in China. A total of 6763 hypertensive patients and 2807 age and sex-matched normotensive subjects with complete data on resting electrocardiogram and medical history were included. Fast RHR was defined as RHR > 85 bpm. RESULTS: The prevalence of fast RHR wa...
Source: Clinical and Experimental Hypertension - December 19, 2018 Category: Cardiology Authors: Li X, Kong T, Yao Y, Chen J, Sun K, Zhang S, Hui R, Fan X Tags: Clin Exp Hypertens Source Type: research

Association of aldosterone synthase CYP11B2 (-344C/T) gene polymorphism with essential hypertension and left ventricular hypertrophy in the Egyptian population.
CONCLUSION: A Significant association was observed between the CYP11B2 (-344C/T) polymorphism and -344T allele and essential hypertension in the Egyptian population. Also, we found that the CYP11B2 -344C/T polymorphism and -344T allele are associated with left ventricular hypertrophy which may predispose to cardiovascular complications of hypertension. PMID: 30561227 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - December 18, 2018 Category: Cardiology Authors: Abdel Ghafar MT Tags: Clin Exp Hypertens Source Type: research

Central aortic pressure improves prediction of cardiovascular events compared to peripheral blood pressure in short-term follow-up of a hypertensive cohort.
CONCLUSIONS: Central pressure improved prediction of CVD compared to peripheral pressure during a relatively short-term follow up of approximately 2 years at age>60 years. PMID: 30554536 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - December 16, 2018 Category: Cardiology Authors: Zuo J, Chang G, Tan I, Butlin M, Chu SL, Avolio A Tags: Clin Exp Hypertens Source Type: research

Prevalence and characteristics of apparent treatment-resistant hypertension in older people in China: a cross-sectional study.
Abstract The prevalence and associated risk factors of apparent treatment-resistant hypertension (aTRH) in older people in China is unknown. The aim of this study is to investigate the prevalence of aTRH in older people and describe the characteristics of older patients with aTRH. Using two-stage random clustering sampling, 3774 patients with hypertension aged ≥60-75 years were recruited between July 2012 and December 2015. The patients were divided into two groups: aTRH and non-aTRH groups according to their blood pressure (BP) levels, and whether or not they reached goal BP value. A multivariable logisti...
Source: Clinical and Experimental Hypertension - December 4, 2018 Category: Cardiology Authors: Wu C, Wang Y, Zhang W, Li X, Wang L, Hui R Tags: Clin Exp Hypertens Source Type: research

The combined effect of serum cystatin C and dyslipidemia on hypertension in a large health check-up population in China.
Abstract OBJECTIVE: Some studies have reported that both serum cystatin C (Cys C) and dyslipidemia are independently associated with hypertension. However, the combined effect of the two factors is still unknown. The present study was aimed at investigating the effect of Cys C combined with dyslipidemia on hypertension in a large health check-up population in China. METHODS: A total of 203 233 health check-up subjects from January 2011 to July 2016 were recruited into this cross-sectional study. A multivariate logistic regression model was used to evaluate the combined effect of Cys C and dyslipidem...
Source: Clinical and Experimental Hypertension - November 29, 2018 Category: Cardiology Authors: Ma J, Wu Z, Zha X, Zhu X, Li W, Jiang M, Wang S, Wu S, Wen Y Tags: Clin Exp Hypertens Source Type: research

Performance of questionnaires aimed at detecting sleep disorders in patients attending a hypertension center.
CONCLUSION: In a population of HT patients, SBQ> 5 performed better at identifying patients with>15 eV/hour with a high discrimination power. PMID: 30497297 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 29, 2018 Category: Cardiology Authors: Schiavone M, Ernst G, Blanco M, Avaca H, Acosta AL, Nosetto D, Manuale O, Salvado A, Borsini E Tags: Clin Exp Hypertens Source Type: research

Berberine suppresses the ectopic expression of miR-133a in endothelial cells to improve vascular dementia in diabetic rats.
CONCLUSION: Berberine improves vascular dementia in diabetes, which is possibly related to the suppression of miR-133a ectopic expression in endothelial cells. PMID: 30472896 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 26, 2018 Category: Cardiology Authors: Yin S, Bai W, Li P, Jian X, Shan T, Tang Z, Jing X, Ping S, Li Q, Miao Z, Wang S, Ou W, Fei J, Guo T Tags: Clin Exp Hypertens Source Type: research

Inferred systolic blood pressure levels to switch from lifestyle modifications to antihypertensive medications: a success-rate oriented simulation.
CONCLUSION: This success rate-oriented simulation proposes that the SBP level to switch from lifestyle modifications to antihypertensive medications can be modulated according to the behavioral propensity for taking antihypertensive medications. ABBREVIATIONS: The following abbreviations are used in this manuscript: CVD: cardiovascular disease; LM: lifestyle modifications; AM: antihypertensive medications; IRCVD: incidence rate of cardiovascular disease (events/year); SBP: systolic blood pressure; ∆IRCVD: the improvements in the incidence rate of cardiovascular disease by lifestyle modifications and/or by antihypert...
Source: Clinical and Experimental Hypertension - November 22, 2018 Category: Cardiology Authors: Ohno Y, Takenaka T, Suzuki H Tags: Clin Exp Hypertens Source Type: research

Correction.
Authors: PMID: 30461323 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 21, 2018 Category: Cardiology Tags: Clin Exp Hypertens Source Type: research

Unique mode of binding between angiotensin II type 1 receptor and its blockers.
CONCLUSIONS: The interaction between 5-oxo-1,2,4-oxadiazole in AZL and Arg167 in the AT1R appears to be more important than the interaction between the tetrazole ring in CAN and Arg167. PMID: 30453795 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 19, 2018 Category: Cardiology Authors: Matsuo Y, Suematsu Y, Tomita S, Tashiro K, Kuwano T, Kitajima K, Miura SI Tags: Clin Exp Hypertens Source Type: research

Long-term low salt diet increases blood pressure by activation of the renin-angiotensin and sympathetic nervous systems.
Conclusion Activation of the renin-angiotensin and sympathetic nervous systems may be involved in the pathogenesis of long-term low salt diet-induced hypertension. PMID: 30451012 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 18, 2018 Category: Cardiology Authors: Wang J, Deng Y, Zou X, Luo H, Jose PA, Fu C, Yang J, Zeng C Tags: Clin Exp Hypertens Source Type: research

Seasonal variation of novel arterial stiffness indexes in Japanese hypertensive patients.
Abstract BACKGROUND AND OBJECTIVE: Seasonal variation of blood pressure (BP) is well known, and a relationship between increases in BP and the incidence of cardiovascular accidents (CVAs) in the winter has been reported. Parameters of arterial stiffness may exhibit seasonal variation; however, available data are currently limited. Novel arterial stiffness indexes, namely the arterial velocity pulse index (AVI) and arterial pressure-volume index (API), can be determined through usual maneuver for BP measurement during the regular examination in the outpatient clinic.The present study assessed the seasonal vari...
Source: Clinical and Experimental Hypertension - November 8, 2018 Category: Cardiology Authors: Kita T, Kitamura K Tags: Clin Exp Hypertens Source Type: research

An intron variant in the FLT1 gene increases the risk of preeclampsia in Iranian women.
CONCLUSIONS: Based on our study, rs722503 polymorphism in the FLT1 gene may play an important role in susceptibility to preeclampsia. PMID: 30409050 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 8, 2018 Category: Cardiology Authors: Amin-Beidokhti M, Gholami M, Abedin-Do A, Pirjani R, Sadeghi H, Karamoddin F, Yassaee VR, Mirfakhraie R Tags: Clin Exp Hypertens Source Type: research

Association between handgrip strength and vascular function in patients with hypertension.
Abstract BACKGROUND: Increased handgrip strength has been associated with lower cardiovascular and non-cardiovascular mortality in different populations. In patients with hypertension, arterial stiffness relates to cardiovascular mortality. However, whether muscle strength is associated with arterial stiffness in hypertensives is unknown. Thus, the objective of this study was to analyze the association between handgrip strength and arterial stiffness parameters in hypertensive patients. METHODS: Seventy-two hypertensive patients completed all evaluations and were included in the analysis. The ambulatory arter...
Source: Clinical and Experimental Hypertension - November 8, 2018 Category: Cardiology Authors: Lima-Junior D, Farah BQ, Germano-Soares AH, Andrade-Lima A, Silva GO, Rodrigues SLC, Ritti-Dias R Tags: Clin Exp Hypertens Source Type: research

Assessment of occurrence of preeclampsia and some clinical and demographic risk factors in Zahedan city in 2017.
CONCLUSION: Maternal BMI, maternal hypertension, history of preeclampsia in previous pregnancies, low maternal educational status, and twin or multiple pregnancies might be the risk factors for preeclampsia during pregnancy. PMID: 30388904 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 2, 2018 Category: Cardiology Authors: Farzaneh F, Tavakolikia Z, Soleimanzadeh Mousavi SH Tags: Clin Exp Hypertens Source Type: research

Taekwondo training reduces blood catecholamine levels and arterial stiffness in postmenopausal women with stage-2 hypertension: randomized clinical trial.
Abstract OBJECTIVE: Menopause is associated with a progressive impairment of vascular function and muscular strength in women. Accordingly, the purpose of this study was to determine if Taekwondo training could improve blood catecholamine levels, arterial stiffness, blood pressure (BP) and skeletal muscle strength in postmenopausal women with stage-2 hypertension. METHODS: 20 postmenopausal women (70 ± 4 years old) with stage-2 hypertension were randomly assigned to a 1) Taekwondo training (TT; n = 10) or 2) Control (CON; n = 10) group. Taekwondo training was performe...
Source: Clinical and Experimental Hypertension - November 2, 2018 Category: Cardiology Authors: Lee SH, Scott SD, Pekas EJ, Lee S, Lee SH, Park SY Tags: Clin Exp Hypertens Source Type: research

Multiparameter assessment of exercise capacity in patients with arterial hypertension.
Abstract INTRODUCTION: Arterial hypertension (AH) can lead to the development of heart failure. AIM: Evaluating the relationship between parameters of exercise capacity assessed via a six-minute walk test (6MWT) and cardiopulmonary exercise test (CPET), with a hemodynamic assessment via impedance cardiography (ICG), in patients with AH. METHODS: Exercise capacity was assessed in 98 hypertensive patients (54.5 ± 8.2 years) by means of oxygen uptake (VO2) get from CPET, 6MWT distance (6MWTd) and hemodynamic parameters measured by ICG: heart rate (HR), stroke volume (SV), cardiac outpu...
Source: Clinical and Experimental Hypertension - October 31, 2018 Category: Cardiology Authors: Kurpaska M, Krzesiński P, Gielerak G, Uziębło-Życzkowska B, Banak M, Piotrowicz K, Stańczyk A Tags: Clin Exp Hypertens Source Type: research

Serum total bilirubin concentration is associated with carotid atherosclerosis in patients with prehypertension.
Abstract OBJECTIVES: Bilirubin has been demonstrated to be linked with anti-inflammatory and antioxidant progress. We aimed to evaluate the association between serum total bilirubin level and carotid intima-media thick-ness (cIMT) in patients with prehypertension. METHODS: We consecutively enrolled pre-hypertensive patients from a community in Guangzhou between January 2017 and January 2018. All patients underwent carotid artery ultrasonography measurement. The correlation between serum total bilirubin and cIMT was assessed by using the Pearson's correlation coefficient. Multiple logistic regression analysis ...
Source: Clinical and Experimental Hypertension - October 30, 2018 Category: Cardiology Authors: Tang LH, Huang C, Feng YQ Tags: Clin Exp Hypertens Source Type: research

Short-term outcome and early effect on blood pressure of laparoscopic sleeve gastrectomy in morbidly obese patients.
Abstract Bariatric surgery has been used to reduce weight and shown to be beneficial for hypertension control. However, little is known about the changes in blood pressure in early stage after laparoscopic sleeve gastrectomy (LSG). We conducted a prospective study of 60 LSG patients with one year-follow-up. The blood pressure of the patients was measured preoperatively and from day 1 to 12 months postoperatively. The use of antihypertensives, body weight, ghrelin and leptin levels were also recorded. Following LSG, excess weight loss (EWL) was 72.6 ± 22.3% and 83.1 ± 19.3% 6 ...
Source: Clinical and Experimental Hypertension - October 29, 2018 Category: Cardiology Authors: Yin X, Qian J, Wang Y, Yang C, Jia B, Cheng Y, Yu G, Wang Y Tags: Clin Exp Hypertens Source Type: research

Renal effects of sodium glucose co-transporter 2 inhibitors in Japanese type 2 diabetes mellitus patients with home blood pressure monitoring.
In conclusion, management of blood pressure both at office and home was found to be important for the reno-protective effects of sodium-glucose cotransporter 2 inhibitors along with strict blood pressure management. PMID: 30373408 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 29, 2018 Category: Cardiology Authors: Kobayashi K, Toyoda M, Kimura M, Hatori N, Furuki T, Sakai H, Takihata M, Umezono T, Ito S, Suzuki D, Takeda H, Kanamori A, Degawa H, Yamamoto H, Machimura H, Mokubo A, Chin K, Obana M, Hishiki T, Aoyama K, Nakajima S, Umezawa S, Shimura H, Aoyama T, Sato Tags: Clin Exp Hypertens Source Type: research

A non-synonymous polymorphism in purinergic P2X7 receptor gene confers reduced susceptibility to essential hypertension in Chinese postmenopausal women.
PMID: 30359160 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 25, 2018 Category: Cardiology Authors: Gong C, Liu X, Ding L, Liu Y, Li T, Wang S, Zhao J, Rao S, Xiong C, Yang Y, Liu C, Liang S, Xu H Tags: Clin Exp Hypertens Source Type: research

Relationship of sleep duration on workdays and non-workdays with blood pressure components in Chinese hypertensive patients.
CONCLUSION: Compared with a sleep duration of 5-9 h, longer sleep duration (≥10 h) on workdays and non-workdays was associated with high SBP and PP among Chinese hypertensive adults without antihypertensive treatment. PMID: 30346849 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 22, 2018 Category: Cardiology Authors: Hu L, Huang X, You C, Bao H, Zhou W, Li J, Li P, Wu Y, Wu Q, Wang Z, Gao R, Liang Q, Cheng X Tags: Clin Exp Hypertens Source Type: research

Forecast post-dialysis blood pressure in hemodialysis patients with intradialytic hypertension.
CONCLUSIONS: The chronic inflammation, poor IDWG control, LV diastolic dysfunction, as well as low serum folic acid and magnesium might be associated with increasing prevalence of IDH in MHD patients. Forecasting models for post-HD SBP could help to control hypertension during HD treatments. PMID: 30325241 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 16, 2018 Category: Cardiology Authors: Zou LX, Sun L Tags: Clin Exp Hypertens Source Type: research

TRPV4 activation in rat carotid artery in DOCA hypertension involves eNOS and endothelium-derived contractile factor (EDCF).
CONCLUSION: TRPV4 may regulate the vascular tone of rat carotid artery through an attenuated NO pathway and stimulation of the release of contractile prostanoids in the DOCA hypertensive rats. PMID: 30325243 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 16, 2018 Category: Cardiology Authors: Dash JR, Mishra SK, Parida S, Singh TU, Choudhury S, Muniyappa K Tags: Clin Exp Hypertens Source Type: research

Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension.
CONCLUSION: ARB treatment is a negative risk factor of arterial stiffness in aged patients with essential hypertension. PMID: 30311805 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 12, 2018 Category: Cardiology Authors: Zhu ML, Sun RL, Zhang HY, Zhao FR, Pan GP, Zhang C, Song P, Li P, Xu J, Wang S, Yin YL Tags: Clin Exp Hypertens Source Type: research

Association of the plasma aldosterone concentration, left atrial deformation and ambulatory blood pressure in never-treated early hypertensive patients.
Abstract Left atrial (LA) strain is known to exhibit an early progressive reduction in hypertensive patients with diastolic dysfunction. However, an association of the renin-angiotensin-*aldosterone system (RAAS) with LA deformation has not been found in these patients. We aimed to investigate the association of plasma aldosterone concentration (PAC) and 24-hour ambulatory blood pressure monitoring (ABPM) with LA and left ventricle (LV) deformation in never-treated early hypertensive patients. This cross-sectional study included 101 never-treated subjects who were registered in a working group at The Catholic Univ...
Source: Clinical and Experimental Hypertension - October 12, 2018 Category: Cardiology Authors: Kim GH, Cho JS, Chung WB, Park CS, Ihm SH Tags: Clin Exp Hypertens Source Type: research

Serum concentration of renin-angiotensin system components in association with ACE I/D polymorphism among hypertensive subjects in response to ACE inhibitor therapy.
CONCLUSIONS: Our results suggest that insufficient blood pressure control by ACE-inhibitory therapy could be associated with elevation of serum ACE2 and chymase levels. Also, it appears that ACE I/D polymorphism may influence the circulating quantity of chymase in addition to ACE. PMID: 30307755 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 11, 2018 Category: Cardiology Authors: Hristova M, Stanilova S, Miteva L Tags: Clin Exp Hypertens Source Type: research

Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5.
Abstract The incidence of hypertension and diabetes is increasing, it is reported that adipocytokines might be involved in the pathogenesis of diabetes and hypertension. We aimed to investigate the features of adipocytokines, included of Leptin, Irisin, LGR4, and Sfrp5 in type 2 diabetes mellitus (T2DM) patients with hypertension, simultaneously analyzed the connection of the alteration of adipocytokines with blood pressure and glucose. 424 patients with T2DM and 90 healthy subjects were included in the study. The patients with T2DM were divided into 4 groups based on the blood pressure. The levels of adipocytokin...
Source: Clinical and Experimental Hypertension - October 11, 2018 Category: Cardiology Authors: Li B, Yao Q, Guo S, Ma S, Dong Y, Xin H, Wang H, Liu L, Chang W, Zhang Y Tags: Clin Exp Hypertens Source Type: research

Predictive value of long noncoding RNA ZFAS1 in patients with ischemic stroke.
Abstract BACKGROUND: LncRNAs play an essential role in a variety of diseases. Zinc finger antisense 1 (ZFAS1), a newly identified lncRNA, is a transcript antisense to the 5' end of the gene Znfx1. The purpose of this study was to aim to compare the levels of ZFAS1 between ischemic stroke (IS) and healthy control subjects and explore its potential role as a noninvasive biomarker in the diagnosis of IS. METHODS:  A total of 176 patients and 111 healthy controls were included in the study. RT-qPCR was performed to detect the expression of ZFAS1. RESULTS: The results showed that level of ZFAS1 in IS pat...
Source: Clinical and Experimental Hypertension - October 11, 2018 Category: Cardiology Authors: Wang J, Ruan J, Zhu M, Yang J, Du S, Xu P, Zhang Z, Wang P, Yang W, Yu M Tags: Clin Exp Hypertens Source Type: research

Risk of high blood pressure associated with objective insomnia and self-reported insomnia complaints in major depression: A study on 703 individuals.
CONCLUSION: In major depression, severe objective insomnia and lower self-reported insomnia complaints are associated with higher risk of high blood pressure, which justifies a better management of objective insomnia and a better assessment of insomnia complaints in this particular subpopulation to avoid the negative consequences related to the co-occurrence of high blood pressure and major depression. ABBREVIATIONS: AHI, Apnea-Hypopnea Index; BDI, Beck Depression Inventory; BMI, Body Mass Index; DSM IV-TR, Diagnostic and Statistical Manual of Mental Disorders fourth edition - Text Revision; ESS, Epworth Sleepiness sc...
Source: Clinical and Experimental Hypertension - October 10, 2018 Category: Cardiology Authors: Hein M, Lanquart JP, Loas G, Hubain P, Linkowski P Tags: Clin Exp Hypertens Source Type: research

A risk prediction model for renal damage in a hypertensive Chinese Han population.
Abstract Backgroud: While numerous risk factors for renal damage in the hypertensive population have been reported, there is no single prediction model. The purpose of this study was to develop a model to comprehensively evaluate renal damage risk among hypertensive patients. Methods: We analyzed the data of 582 Chinese hypertensive patients from 1 January 2013 to 30 June 2016. Basic patient information was collected along with laboratory test results. According to the albumin-to-creatinine ratio, the subjects were divided into a hypertension with renal damage group and a hypertension without r...
Source: Clinical and Experimental Hypertension - October 9, 2018 Category: Cardiology Authors: Lin J, Xu R, Yun L, Hou Y, Li C, Lian Y, Zheng F Tags: Clin Exp Hypertens Source Type: research

Renal resistive index significantly increased in hypertensive children and it is independently related to the pulse pressure and left ventricular mass index.
In this study, we aimed to investigate the changes of RRI values and it is usability in children with HT. METHODS: A total of 75 children; 48 with newly diagnosed HT and 27 healthy controls were included in the study. Routine history, physical examination, and laboratory examinations were performed. Left ventricular (LV) dimensions and systolic-diastolic functions, septum and posterior wall thickness (IVSd and PWd) and LV mass index (LVMI) were calculated by echocardiography. In addition to routine renal ultrasonography (US), renal pulsatility indexes (RPI), accelerated time and RRI were measured. Increased RRI was ac...
Source: Clinical and Experimental Hypertension - October 4, 2018 Category: Cardiology Authors: Cilsal E, Koc AS Tags: Clin Exp Hypertens Source Type: research

Hypertensive emergencies in diabetic patients from predominantly African American urban communities.
CONCLUSION: The development of hypertensive emergencies in patients with diabetes was not because of diabetes per se but because of coexisting highly elevated blood pressure. Tight blood pressure control may decrease the risk of hypertensive emergencies in this patient population. PMID: 30285508 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 4, 2018 Category: Cardiology Authors: Benenson I, Waldron FA, Jones Dillon SA, Zinzuwadia SN, Mbadugha N, Vicente N, Aris E, Adeboye AM, Makdisi C Tags: Clin Exp Hypertens Source Type: research

Relationship between the NF- κB1-94ins/del ATTG locus polymorphism and risk of hypertension in the Chinese Han population.
Relationship between the NF-κB1-94ins/del ATTG locus polymorphism and risk of hypertension in the Chinese Han population. Clin Exp Hypertens. 2018 Oct 04;:1-6 Authors: Chen J, Ge D, Xiong Y Abstract OBJECTIVE: The onset of essential hypertension is the result of a combination of genetic factors and the environment. The nuclear factor (NF)-κB1-94ins/del ATTG locus polymorphism is associated with the occurrence of various diseases. The purpose of this study was to find out the relationship between the NF-κB1-94ins/del ATTG locus polymorphism and the risk of hypertension in the Chinese ...
Source: Clinical and Experimental Hypertension - October 4, 2018 Category: Cardiology Authors: Chen J, Ge D, Xiong Y Tags: Clin Exp Hypertens Source Type: research

Induced carotid atherosclerosis in lupus mice.
Abstract Fas knockout (Fas-/-) mice are a model for systemic lupus erythematosus (SLE) -like autoimmune syndromes. We aimed to induce atherosclerosis (AS) in Fas-/- mice. Sixteen male Fas-/- mice were included in the study, sex-matched C57B6/L (B6) and apolipoprotein E-knockout (ApoE-/-) mice were negative and positive AS controls, respectively. A silica collar was placed around the right carotid artery of each mouse to induce AS development. All mice were fed a 24-week high-fat diet, and investigated for AS lesions. We also compared the levels of blood lipid and glucose, serum tumor necrosis factor α (TNF-&...
Source: Clinical and Experimental Hypertension - September 20, 2018 Category: Cardiology Authors: Wang Y, Huang Z, Lin L, Huang G, Liu W, Xue Y Tags: Clin Exp Hypertens Source Type: research

Left ventricular hypertrophy is associated with increased sirtuin level in newly diagnosed hypertensive patients.
The objective of this study was to evaluate the relation of serum SIRT1 level with left ventricular hypertrophy (LVH) in newly diagnosed hypertensive patients. METHODS: One hundered and twenty-five consecutive, newly diagnosed hypertensive patients were divided into two groups with regard to presence of LVH and compared to 40 healthy control subjects. LVH was determined by transthoracic echocardiography using the cube formula. Serum SIRT1 level was analyzed with enzyme-linked immunosorbent assay. RESULTS: Serum SIRT1 level was significantly higher in patients with LVH compared to those without LVH (14.3 &plu...
Source: Clinical and Experimental Hypertension - September 19, 2018 Category: Cardiology Authors: Duman H, Bahçeci I, Çinier G, Duman H, Bakırcı EM, Çetin M Tags: Clin Exp Hypertens Source Type: research