Filtered By:
Condition: Hypertension
This page shows you your search results in order of date. This is page number 7.
Order by Relevance | Date
Total 587 results found since Jan 2013.
IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis
CONCLUSIONS: IL-11 and IL-11Rα are overexpressed in pulmonary arteries of PH associated to IPF patients, and contributes to pulmonary artery remodeling and PH.PMID:36376885 | DOI:10.1186/s12931-022-02241-0
Source: Cell Research - November 15, 2022 Category: Cytology Authors: Javier Milara In és Roger Paula Montero Enrique Artigues Juan Escriv á Julio Cortijo Source Type: research
Iron metabolism disorder regulated by BMP signaling in hypoxic pulmonary hypertension
CONCLUSIONS: Iron deficiency promoted oxidative stress and apoptosis in HPAECs in hypoxia-induced PH, and enhanced expression of hepcidin regulated by BMP6/BMPR2 signaling may contribute to iron metabolic disorder.PMID:36343841 | DOI:10.1016/j.bbadis.2022.166589
Source: Biochimica et Biophysica Acta - November 7, 2022 Category: Biochemistry Authors: Yujie Jiang Yingfan Guo Xuexiang Feng Pingting Yang Yi Liu Xuejing Dai Feilong Zhao Dongyu Lei Xiaohui Li Yuan Liu Ying Li Source Type: research
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling
In conclusion, SIRT7 alleviates renal ferroptosis, lipid peroxidation, and partial EMT under hypertensive status by facilitating the KLF15/Nrf2 signaling, thereby mitigating renal fibrosis, injury and dysfunction. Targeting SIRT7 signaling serves as a promising strategy for hypertension and hypertensive renal injury.PMID:36334846 | DOI:10.1016/j.freeradbiomed.2022.10.320
Source: Free Radical Biology and Medicine - November 5, 2022 Category: Biology Authors: Xue-Ting Li Jia-Wei Song Zhen-Zhou Zhang Mi-Wen Zhang Li-Rong Liang Ran Miao Ying Liu Yi-Hang Chen Xiao-Yan Liu Jiu-Chang Zhong Source Type: research
Function of connexin 43 and RhoA/LIMK2/Cofilin signaling pathway in transient changes of contraction and dilation of human umbilical arterial smooth muscle cells
CONCLUSION: The function of Cx43-GJs lies in the center of Ang Ⅱ-induced contraction of HUASMCs, which potentially regulates intracellular Ca2+ mobility as well as RhoA/LIMK2/Cofilin signaling pathway activity. Propofol can reverse this effect induced by Ang Ⅱ through suppressing the function of Cx43-GJs.PMID:36330887 | DOI:10.1016/j.biocel.2022.106326
Source: The International Journal of Biochemistry and Cell Biology - November 4, 2022 Category: Biochemistry Authors: Zhizhao Deng Yanling Zhang Qian Zhang Xianlong Li Weiqi Zeng Cai Jun Dongdong Yuan Source Type: research
Integrin subunit β-like 1 mediates angiotensin II-induced myocardial fibrosis by regulating the forkhead box Q1/Snail axis
Arch Biochem Biophys. 2022 Sep 29:109422. doi: 10.1016/j.abb.2022.109422. Online ahead of print.ABSTRACTCardiac fibrosis is a severe condition with limited therapeutic options and often occurs in chronic cardiovascular diseases such as hypertension and myocardial infarction. There is currently a clear need to identify novel mediators of cardiac fibrosis to facilitate the development of more effective therapeutic strategies targeting cardiac fibrosis. Integrin subunit β-like 1 (ITGBL1), an extracellular matrix protein, has previously been implicated in various fibrotic diseases. However, the precise role of ITGBL1 in regul...
Source: Archives of Biochemistry and Biophysics - October 2, 2022 Category: Biochemistry Authors: Hui Zhu Hongxue Ji Weiming Chen Lu Han Liangzhu Yu Source Type: research
BMPR1A Promotes ID2-ZEB1 Interaction to Suppress Excessive Endothelial to Mesenchymal Transition
CONCLUSIONS: We demonstrate that BMPR1A is key to maintain endothelial identity and to prevent excessive EndoMT. We identify BMPR1A-induced interaction between ID2 and ZEB1 is the key regulatory step for onset of EndoMT and pathogenesis of PAH. Our findings indicate that BMPR1A-ID2/ZEB1-TGFBR2 signaling axis could serve as a potential novel therapeutic target for PAH and other EndoMT-related vascular disorders.PMID:36166408 | DOI:10.1093/cvr/cvac159
Source: Cell Research - September 27, 2022 Category: Cytology Authors: Heon Woo Lee Takaomi Adachi Boryeong Pak Saejeong Park Xiaoyue Hu Woosoung Choi Piotr S Kowalski C Hong Chang Katharine R Clapham Aram Lee Irinna Papangeli Jongmin Kim Orjin Han Jihwan Park Daniel G Anderson Michael Simons Suk Won Jin Hyung J Chun Source Type: research
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension
CONCLUSIONS: In human PAH and experimental PH, Orai1 expression and activity are increased. Orai1 inhibition normalizes the PAH-hPASMCs phenotype and attenuates PH in rat models. These results suggest that Orai1 should be considered as a relevant therapeutic target for PAH.PMID:36164973 | DOI:10.1161/CIRCRESAHA.122.321041
Source: Circulation Research - September 27, 2022 Category: Cardiology Authors: Bastien Masson H élène Le Ribeuz Jessica Sabourin Loann Laubry Emily Woodhouse Richard Foster Yann Ruchon Mary Dutheil Ang èle Boët Maria-Rosa Ghigna Vincent De Montpreville Olaf Mercier David J Beech Jean-Pierre Benitah Marc A Bailey Marc Humbert Dav Source Type: research
Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT and is associated with pulmonary hypertension
Am J Physiol Heart Circ Physiol. 2022 Sep 23. doi: 10.1152/ajpheart.00220.2022. Online ahead of print.ABSTRACTMechanical forces are translated into biochemical stimuli by mechanotransduction channels, such as the mechanically-activated cation channel Piezo2. Lung Piezo2 expression has recently been shown to be restricted to endothelial cells. Hence, we aimed to investigate the role of Piezo2 in regulation of pulmonary vascular function and structure as well as its contribution to development of pulmonary arterial hypertension (PAH). The expression of Piezo2 was significantly reduced in pulmonary microvascular endothelial c...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 23, 2022 Category: Physiology Authors: Siyu Tian Zongye Cai Payel Sen Denise van Uden Esther van de Kamp Raphael Thuillet Ly Tu Christophe Guignabert Karin Boomars Kim Van der Heiden Maarten M Brandt Daphne Merkus Source Type: research
