Filtered By:
Condition: Hypertension

This page shows you your search results in order of date. This is page number 12.

Order by Relevance | Date

Total 587 results found since Jan 2013.

Vascular smooth muscle ROCK1 contributes to hypoxia-induced pulmonary hypertension development in mice
Biochem Biophys Res Commun. 2022 Mar 9;604:137-143. doi: 10.1016/j.bbrc.2022.02.064. Online ahead of print.ABSTRACTRho kinase (ROCK) is implicated in the development of pulmonary arterial hypertension (PAH) in which abnormal pulmonary vascular smooth muscle (VSM) contractility and remodeling lead to right heart failure. Pharmacologic ROCK inhibitors block experimental pulmonary hypertension (PH) development in rodents but can have off-target effects and do not distinguish between the two ROCK forms, ROCK1 and ROCK2, encoded by separate genes. An earlier study using gene knock out (KO) in mice indicated that VSM ROCK2 is re...
Source: Cell Research - March 18, 2022 Category: Cytology Authors: Krishna C Penumatsa Adit A Singhal Rod R Warburton Michael D Bear Chinmayee D Bhedi Sabina Nasirova Jamie L Wilson Guanming Qi Ioana R Preston Nicholas S Hill Barry L Fanburg Young-Bum Kim Deniz Toksoz Source Type: research

Renoprotective Effect of KLF2 on Glomerular Endothelial Dysfunction in Hypertensive Nephropathy
Cells. 2022 Feb 22;11(5):762. doi: 10.3390/cells11050762.ABSTRACTKruppel-like factor 2 (KLF2) regulates endothelial cell metabolism; endothelial dysfunction is associated with hypertension and is a predictor of atherosclerosis development and cardiovascular events. Here, we investigated the role of KLF2 in hypertensive nephropathy by regulating KLF2 expression in human primary glomerular endothelial cells (hPGECs) and evaluating this expression in the kidney tissues of a 5/6 nephrectomy mouse model as well as patients with hypertension. Hypertension-mimicking devices and KLF2 siRNA were used to downregulate KLF2 expression...
Source: Atherosclerosis - March 10, 2022 Category: Cardiology Authors: Eunjin Bae Mi-Yeon Yu Jong-Joo Moon Ji-Eun Kim Saram Lee Sang-Woong Han Dong-Jun Park Yon-Su Kim Seung-Hee Yang Source Type: research

PM < sub > 2.5 < /sub > increases mouse blood pressure by activating toll-like receptor 3
CONCLUSIONS: PM2.5 exposure increased BP via TLR3 activation and impaired vascular function.PMID:35247710 | DOI:10.1016/j.ecoenv.2022.113368
Source: Ecotoxicology and Environmental Safety - March 5, 2022 Category: Environmental Health Authors: Jinna Zhang Rucheng Chen Guoqing Zhang Yixuan Wang Jing Peng Renjie Hu Ran Li Weijia Gu Lu Zhang Qinghua Sun Cuiqing Liu Source Type: research

Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling
In conclusion, elabela antagonizes Ang II-mediated promotion of CMVECs ferroptosis, adverse myocardial remodeling, fibrosis and heart dysfunction through modulating the IL-6/STAT3/GPX4 signaling pathway. Targeting elabela-APJ axis serves as a novel strategy for hypertensive heart diseases.PMID:35122997 | DOI:10.1016/j.freeradbiomed.2022.01.020
Source: Free Radical Biology and Medicine - February 5, 2022 Category: Biology Authors: Zhenzhou Zhang Jianqiong Tang Jiawei Song Mengshi Xie Ying Liu Zhaojie Dong Xiaoyan Liu Xueting Li Miwen Zhang Yihang Chen Hongyu Shi Jiuchang Zhong Source Type: research

Calcitriol ameliorates renal injury with high-salt diet-induced hypertension by upregulating GLIS2 expression and AMPK/mTOR-regulated autophagy
Gene. 2022 Jan 31:146239. doi: 10.1016/j.gene.2022.146239. Online ahead of print.ABSTRACTThe goal of the present study was to investigate the protective effect of calcitriol on high-salt diet-induced hypertension. The hypertension rat model was established by a long-term high-salt diet (8% NaCl). Rats were treated with calcitriol, losartan, or their combination. Histological staining was used to confirm renal pathology. Global transcriptome analysis of renal tissues was performed, and the mechanism of the therapeutic effect of calcitriol was analysed by functional annotation and pathway analysis of the differentially expre...
Source: Gene - February 3, 2022 Category: Genetics & Stem Cells Authors: Ruifeng Ding Yufeng Jiang Yi Yang Yong Shi Yang Ji Timing Zhen Zhiliang Fu Xunxia Bao Jia Tan Shuyong Zhang Jiahui Li Kaichen Xing Xinli Zhou Sibo Zhu Source Type: research

Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling pathways in hypoxic pulmonary hypertension
CONCLUSIONS: These findings reveal an important role of the Notch4-ERK/JNK/P38 MAPK axis in hypoxic pulmonary remodeling and provide a potential therapeutic target for patients with HPH.PMID:35016680 | DOI:10.1186/s12931-022-01927-9
Source: Respiratory Care - January 12, 2022 Category: Respiratory Medicine Authors: Mingzhou Guo Mengzhe Zhang Xiaopei Cao Xiaoyu Fang Ke Li Lu Qin Yuanzhou He Jianping Zhao Yongjian Xu Xiansheng Liu Xiaochen Li Source Type: research

Sirtuin1 contributes to the overexpression of Giα proteins and hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats
Conclusion: In summary, our results demonstrate that Sirt1 is overexpressed in VSMC from SHR which through augmenting oxidative stress contributes to the enhanced expression of Giα proteins, cell cycle proteins and resultant hyperproliferation of VSMC.
Source: Journal of Hypertension - December 10, 2021 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research

Role of Connexin 43 increased expression in pulmonary arterial hyperreactivityinduced by the nerve growth factor NGF
In conclusion, NGF pathway is upregulated in IPAH cells. NGF increases Cx43 PA expression through activation of its TrkA receptor. NGF-induced Cx43 increased expression upregulates GAP junction activity, thus promoting PA hyperreactivity.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Cardouat, g., Douard, M., Roubenne, L., Bouchet, C., Kmecova, Z., Robillard, P., Guignabert, C., Tu, L., Delcambre, F., Marthan, R., Muller, B., Guibert, C., Freund-Michel, V. Tags: Pulmonary hypertension Source Type: research

Late Breaking Abstract - Involvement of Orai1 Ca2+ channel in the pathogenesis of pulmonary arterial hypertension. Orai1 as a new potential therapeutic target ?
Conclusion: Altogether our results provide proof of concept that Orai1 should be considered as a new therapeutic target in PAH.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Masson, B., Le Ribeuz, H., Sabourin, J., Woodhouse, E., Foster, R., Ruchon, Y., Dutheil, M., Boët, A., Ghigna, M.-R., Mercier, O., Beech, D., Benitah, J.-P., Bailey, M., Humbert, M., Montani, D., Capuano, V., Antigny, F. Tags: Pulmonary hypertension Source Type: research

Hypertensive effects of transforming growth factor- β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2
In this study, we examined the role of extracellular sulfatases on TGF-β1-induced effects associated with the expression of mediators related to hypertension in vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR). First, TGF-β1 increased the expression of 12-lipoxygenase (12-LO) and endothelin-1 (ET-1), inhibited dimethylarginine dimethylaminohydrolase-1 (DDAH-1) expression and showed additive effects on Ang II-induced 12-LO and ET-1 expression as well as Ang II-induced inhibition of DDAH-1 expression in SHR VSMCs. However, it had no effect on the expression of 12-LO, ET-1, and DDAH-1 in VSMCs...
Source: Cytokine - November 22, 2021 Category: Molecular Biology Authors: Hee Sun Kim Hye Young Kim Source Type: research

Endothelial Upregulation of Mechanosensitive Channel Piezo1 in Pulmonary Hypertension
Am J Physiol Cell Physiol. 2021 Oct 20. doi: 10.1152/ajpcell.00147.2021. Online ahead of print.ABSTRACTPiezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+ influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung vasculature and its potential pathogenic role in pulmonary arterial hypertension (PAH). Pulmonary arterial endothelial cells (PAECs) are constantly under mechanic stretch and shear stress that are sufficient to activate Piezo channels. Here we report that Piezo1 is significantly upregulated in PAECs from patients with idiopathic PAH and ...
Source: Am J Physiol Cell Ph... - October 20, 2021 Category: Cytology Authors: Ziyi Wang Jiyuan Chen Aleksandra Babicheva Pritesh P Jain Marisela Rodriguez Ramon J Ayon Keeley S Ravellette Linda Wu Francesca Balistrieri Haiyang Tang Xiaomin Wu Tengteng Zhao Stephen M Black Ankit A Desai Joe G N Garcia Xin Sun John Y-J Shyy Daniela V Source Type: research