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Condition: Hypertension

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Total 587 results found since Jan 2013.

SIRT1 exerts anti-hypertensive effect via FOXO1 activation in the rostral ventrolateral medulla
Free Radic Biol Med. 2022 Jun 7:S0891-5849(22)00223-4. doi: 10.1016/j.freeradbiomed.2022.06.003. Online ahead of print.ABSTRACTThe rostral ventrolateral medulla (RVLM) is a pivotal region in the central regulation of blood pressure (BP). It has been documented that silent information regulator 2 homolog 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent multifunctional transcription regulatory factor, has many cardiovascular protective effects. However, the role and significance of SIRT1 in the central regulation of cardiovascular activity, especially in RVLM, remains unknown. Therefore, the aim of this study ...
Source: Free Radical Biology and Medicine - June 10, 2022 Category: Biology Authors: Chang-Zhen Ren Zhao-Tang Wu Wen Wang Xing Tan Ya-Hong Yang Yang-Kai Wang Miao-Ling Li Wei-Zhong Wang Source Type: research

Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase ‐2 expression and proliferation
We hypothesized that the release of epidermal growth factor (EGF) by human pulmonary microvascular endothelial cells (hPMVEC) could result in the proliferation of human pulmonary arterial smooth muscle cells via activation of the EGF receptor (EGFR) on the hPASMC leading to Arg2 up-regulation. Our data suggest that hypoxic hPMVEC do release EGF, which activates hPASMC EGFR leading to Arg2 protein expression and an increase in viable smooth muscle cell numbers. AbstractThe hallmark of pulmonary hypertension (PH) is vascular remodeling. We have previously shown that human pulmonary microvascular endothelial cells (hPMVEC) re...
Source: Physiological Reports - June 9, 2022 Category: Physiology Authors: Bernadette Chen, Yi Jin, Caitlyn M. Pool, Yusen Liu, Leif D. Nelin Tags: ORIGINAL ARTICLE Source Type: research

Silencing of Fli1 gene mimics effects of preeclampsia and induces collagen synthesis in human umbilical arteries
CONCLUSIONS: Our results show that after silencing the Fli1 gene in healthy human umbilical arteries a new phenotype emerges which is typical for preeclampsia and is associated with vascular fibrosis.PMID:35569064 | DOI:10.1093/ajh/hpac065
Source: American Journal of Hypertension - May 15, 2022 Category: Cardiology Authors: Natalia I Agalakova Vitaly A Reznik Ivan A Ershov Ekaterina A Lupanova Olga V Nadei Dmitry O Ivanov C David Adair Alexei Y Bagrov Source Type: research

Y-Chromosome Gene, < em > Uty < /em > , Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines
CONCLUSIONS: Uty, is protective against PH. Reduction of Uty expression results in increased expression of proinflammatory chemokines CXCL9 and CXCL10 which trigger endothelial cell death and PH. Inhibition of Cxcl9 and Cxcl10 rescues PH development in multiple experimental models.PMID:35504005 | DOI:10.1164/rccm.202110-2309OC
Source: Respiratory Care - May 3, 2022 Category: Respiratory Medicine Authors: Christine M Cunningham Min Li Gregoire Ruffenach Mitali Doshi Laila Aryan Jason Hong John Park Haley Hrncir Lejla Medzikovic Soban Umar Arthur P Arnold Mansoureh Eghbali Source Type: research

VPO1/HOCl/ERK pathway mediates the right ventricular remodeling in rats with hypoxic pulmonary hypertension
This study aims to explore whether VPO1 contributes to hypoxia-induced cardiac hypertrophy and the underlying mechanisms. SD rats were exposure to continuous hypoxia (10% O2) for 3 weeks, which showed RV hypertrophy (increases in the ratio of RV weight to tibia length, cardiac cell size and hypertrophic markers), concomitant with upregulation of VPO1, elevation in hypochlorous acid (HOCl) production and ERK phosphorylation. In hypoxia (3% O2)-induced hypertrophic H9c2 cells, similar characteristics of cardiac hypertrophy to that of hypoxia-treated rats were observed. Administration of VPO1 siRNA or NaHS (the HOCl inhibitor...
Source: Archives of Biochemistry and Biophysics - April 28, 2022 Category: Biochemistry Authors: Tao Li Bin Liu Xiu-Ju Luo Jun Peng Source Type: research

SKF96365 activates calcium-sensing receptors in pulmonary arterial smooth muscle cells
Biochem Biophys Res Commun. 2022 Mar 25;607:44-48. doi: 10.1016/j.bbrc.2022.03.121. Online ahead of print.ABSTRACTIn pulmonary arterial smooth muscle cells (PASMCs), an increase in the cytosolic Ca2+ concentration ([Ca2+]cyt) is involved in many physiological processes such as cell contraction and proliferation. However, chronic [Ca2+]cyt increases cause pulmonary vasoconstriction and vascular remodeling, resulting in pulmonary arterial hypertension (PAH). Therefore, [Ca2+]cyt signaling plays a substantial role in the regulation of physiological and pathological functions in PASMCs. In the present study, the effects of SKF...
Source: Biochemical and Biophysical Research communications - April 2, 2022 Category: Biochemistry Authors: Riko Miyaki Aya Yamamura Akiko Kawade Moe Fujiwara Rubii Kondo Yoshiaki Suzuki Hisao Yamamura Source Type: research