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Condition: Hypertension

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Total 587 results found since Jan 2013.

Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.
Conclusions: MCT-RVfib manifest a DNMT1-HIF-1α-PDK-mediated, chamber-specific, metabolic memory that promotes collagen production and RV fibrosis. This epigenetic mitochondrial-metabolic pathway is a potential antifibrotic therapeutic target. PMID: 32216531 [PubMed - as supplied by publisher]
Source: Circulation Research - March 26, 2020 Category: Cardiology Authors: Tian L, Wu D, Dasgupta A, Chen KH, Mewburn J, Potus F, Lima PA, Hong Z, Zhao YY, Hindmarch C, Kutty S, Provencher S, Bonnet S, Sutendra G, Archer SL Tags: Circ Res Source Type: research

Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease.
In conclusion, we identified CHOP and HO-1 inhibition, and BMP9 as potential therapeutic options for PVOD. PMID: 32209028 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory Cell and Molecular Biology - March 24, 2020 Category: Molecular Biology Authors: Manaud G, Nossent EJ, Lambert M, Ghigna MR, Boët A, Vinhas MC, Ranchoux B, Dumas SJ, Courboulin A, Girerd B, Soubrier F, Bignard J, Claude O, Lecerf F, Hautefort A, Florio M, Sun B, Nadaud S, Verleden SE, Remy S, Anegon I, Bogaard HJ, Mercier O, Fadel E, Tags: Am J Respir Cell Mol Biol Source Type: research

Inhibition of RELM-β prevents hypoxia-induced overproliferation of human pulmonary artery smooth muscle cells by reversing PLC-mediated KCNK3 decline
Publication date: Available online 8 February 2020Source: Life SciencesAuthor(s): Linlin Han, Nannan Song, Xiaomin Hu, Afang Zhu, Xin Wei, Jinmin Liu, Shiying Yuan, Weike Mao, Xiangdong ChenAbstractAimsAlthough resistin-like molecule β (RELM-β) is involved in the pathological processes of various lung diseases, such as pulmonary inflammation, asthma and fibrosis, its potential roles in hypoxic pulmonary arterial hypertension (PAH) remain largely unknown. The study aims to investigate whether RELM-β contributes to hypoxia-induced excessive proliferation of human pulmonary artery smooth muscle cells (PASMCs) and to explor...
Source: Life Sciences - February 9, 2020 Category: Biology Source Type: research

Leukotriene B4 induces proliferation of rat pulmonary arterial smooth muscle cells via modulating GSK-3 β/β-catenin pathway.
Leukotriene B4 induces proliferation of rat pulmonary arterial smooth muscle cells via modulating GSK-3β/β-catenin pathway. Eur J Pharmacol. 2019 Nov 23;:172823 Authors: Li S, Zhai C, Shi W, Feng W, Xie X, Pan Y, Wang J, Yan X, Chai L, Wang Q, Zhang Q, Liu P, Li M Abstract Leukotriene B4 (LTB4) has been found to contribute to pulmonary arterial smooth muscle cells (PASMCs) proliferation and pulmonary arterial remodeling therefore the development of pulmonary arterial hypertension (PAH). Yet, the underlying molecular mechanisms remain poorly understood. The present study aims to address this issue. O...
Source: European Journal of Pharmacology - November 22, 2019 Category: Drugs & Pharmacology Authors: Li S, Zhai C, Shi W, Feng W, Xie X, Pan Y, Wang J, Yan X, Chai L, Wang Q, Zhang Q, Liu P, Li M Tags: Eur J Pharmacol Source Type: research

Late Breaking Abstract - The effects of BMPRII loss on endothelial shear adaptation in the pulmonary vascular endothelium
Conclusion: Reduced BMPRII expression may contribute to PAH by engendering abnormal pulmonary artery endothelial shear adaptation.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Mahomed, A., Burke-Gaffney, A., Moledina, S., Wort, S. J. Tags: Pulmonary hypertension Source Type: research

TRPV4 channel mediates adventitial fibroblast activation and adventitial remodeling in pulmonary hypertension.
Abstract Pulmonary arterial adventitial fibroblasts (PAF), the most abundant cellular constituent of adventitia, act as a key regulator of pulmonary vascular wall structure and function from the outside-in. Previous studies indicate that Transient Receptor Potential Vanilloid 4 (TRPV4) channel plays an important role in the development of pulmonary hypertension (PH), but no attention has been given so far to its role in adventitial remodeling. In the present study, we thus investigated TRPV4 implication in PAF activation occurring in PH. First, we isolated and cultured PAF from rat adventitial intrapulmonary arter...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 5, 2019 Category: Cytology Authors: Cussac LA, Cardouat G, Tiruchellvam Pillai N, Campagnac M, Robillard P, Montillaud A, Guibert C, Gailly P, Marthan R, Quignard JF, Savineau JP, Ducret T Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Kr üppel-like factor 15 is a key suppressor of podocyte fibrosis under rotational force-driven pressure.
Krüppel-like factor 15 is a key suppressor of podocyte fibrosis under rotational force-driven pressure. Exp Cell Res. 2019 Nov 04;:111706 Authors: Yu MY, Kim JE, Lee S, Choi JW, Kim YC, Han SS, Lee H, Cha RH, Lee JP, Lee JW, Kim DK, Kim YS, Yang SH Abstract Krüppel-like factor 15 (KLF15) is a well-known transcription factor associated with podocyte injury and fibrosis. Recently, hypertensive nephropathy was discovered to be closely related to podocyte injury and fibrosis. However, methods to stimulate hypertension in vitro are lacking. Here, we constructed an in vitro model mimicking hypertension us...
Source: Experimental Cell Research - November 3, 2019 Category: Cytology Authors: Yu MY, Kim JE, Lee S, Choi JW, Kim YC, Han SS, Lee H, Cha RH, Lee JP, Lee JW, Kim DK, Kim YS, Yang SH Tags: Exp Cell Res Source Type: research

Study identifies therapeutic target for high blood pressure in the lungs
This study was supported by grants from the National Institutes of Health and the American Heart Association; and by the Foundation for Anesthesia Education and Research.
Source: UCLA Newsroom: Health Sciences - October 1, 2019 Category: Universities & Medical Training Source Type: news

Nitrendipine, an antihypertensive alpha calcium channel blocker, is cytotoxic to neuroblastoma cells
ConclusionNTD induced apoptosis on neuroblastoma cells, appears to be independent of the expression of the L-type calcium channel.
Source: Molecular and Cellular Toxicology - September 30, 2019 Category: Cytology Source Type: research

Genomic/proteomic analyses of dexamethasone-treated human trabecular meshwork cells reveal a role for GULP1 and ABR in phagocytosis.
Conclusion: The DEX-induced inhibition of phagocytosis may be caused by the downregulation of ABR and GULP1 disrupting the αvβ5 integrin/RAC1-mediated engulfment pathway. The downregulation of GULP1 by αvβ3 integrin further suggests that this integrin may be a negative regulator of phagocytosis by transcriptionally downregulating proteins needed for phagocytosis. In summary, these results represent new insights into the effects of glucocorticoids and integrin signaling on the phagocytic process in the TM. PMID: 31516309 [PubMed - in process]
Source: Molecular Vision - September 14, 2019 Category: Molecular Biology Tags: Mol Vis Source Type: research

Dysfunction of B-cell lymphoma 2/adenovirus E1B 19KD interacting protein 3 in decidua is involved in the pathogenesis of preeclampsia
Conclusion: This study indicates that BNIP3 is particularly important for decidualization and may contribute to both the occurrence and development of preeclampsia via mTOR/p70s6k/BCL-2 signaling pathways.
Source: Journal of Hypertension - August 31, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research

G Protein-Coupled Estrogen Receptor Protects From Angiotensin II-Induced Increases in Pulse Pressure and Oxidative Stress
Our previous work showed that the G protein-coupled estrogen receptor (GPER) is protective in the vasculature and kidneys during angiotensin (Ang) II-dependent hypertension by inhibiting oxidative stress. The goal of the current study was to assess the impact of GPER deletion on sex differences in Ang II-induced hypertension and oxidative stress. Male and female wildtype and GPER knockout mice were implanted with radiotelemetry probes for measurement of baseline blood pressure before infusion of Ang II (700 ng/kg/min) for two weeks. Mean arterial pressure was increased to the same extent in all groups, but female wildtype ...
Source: Frontiers in Endocrinology - August 26, 2019 Category: Endocrinology Source Type: research

A study on the involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension.
In conclusion, our study reveals that inhibition of FAS decreases RV hypertrophy and improves cardiac function associated with PH by perking up metabolic functions. PMID: 31465767 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - August 25, 2019 Category: Cytology Authors: Singh N, Shafiq M, Jagavelu K, Hanif K Tags: Exp Cell Res Source Type: research

LncRNA AK094457 promotes AngII-mediated hypertension and endothelial dysfunction through suppressing of activation of PPARγ
In conclusion, lncRNA AK094457 is identified as a key regulator in blood pressure and endothelial function, which can increase AngII-induced hypertension and endothelial dysfunction via suppression of PPARγ.
Source: Life Sciences - August 14, 2019 Category: Biology Source Type: research

Free heme regulates placenta growth factor through NRF2-antioxidant response signaling.
Abstract Free heme activates erythroblasts to express and secrete Placenta Growth Factor (PlGF), an angiogenic peptide of the VEGF family. High circulating levels of PlGF have been associated in experimental animals and in patients with sickle cell disease with echocardiographic markers of pulmonary hypertension, a life-limiting complication associated with more intense hemolysis. We now show that the mechanism of heme regulation of PlGF requires the contribution of the key antioxidant response regulator NRF2. Mimicking the effect of heme, the NRF2 agonist sulforaphane stimulates the PlGF transcript level nearly 3...
Source: Free Radical Biology and Medicine - August 9, 2019 Category: Biology Authors: Kapetanaki MG, Gbotosho OT, Sharma D, Weidert F, Ofori-Acquah SF, Kato GJ Tags: Free Radic Biol Med Source Type: research