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Condition: Hypertension

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Total 587 results found since Jan 2013.

Nanocarriers Assisted siRNA Gene Therapy for the Management of Cardiovascular Disorders.
This article reviews the application of siRNA against CVDs with special emphasis on gene targets in combination with delivery systems such as cationic hydrogels, polyplexes, peptides, liposomes and dendrimers. PMID: 26471319 [PubMed - in process]
Source: Current Pharmaceutical Design - October 18, 2015 Category: Drugs & Pharmacology Authors: Maheshwari R, Tekade M, Sharma PA, Tekade RK Tags: Curr Pharm Des Source Type: research

Amelioration of cirrhotic portal hypertension by targeted cyclooxygenase-1 siRNA delivery to liver sinusoidal endothelium with polyethylenimine grafted hyaluronic acid
In this study, hyaluronate-graft-polyethylenimine (HA-PEI) was synthesized for the targeted delivery of COX-1 siRNA to LSECs. Compared to non-targeted PEI, HA-PEI mediated much more efficient siRNA delivery, which resulted in potent targeted gene silencing in LSECs. In vivo, HA-PEI notably increased the accumulation of siRNA along the sinusoidal lining of the liver, inhibited over-activation of the COX-1/TXA2 pathway in LSECs, and successfully reduced portal pressure in cirrhotic mice. These results highlight the potential of HA-PEI complexed siRNA to serve as a LSECs-specific nanomedical system for effective gene therapy ...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - July 13, 2017 Category: Nanotechnology Source Type: research

GSE214742 CRISPR and siRNA manipulation of SOX17 in human pulmonary artery endothelial cells HPAEC
Contributors : Christopher J Rhodes ; Rachel Walters ; Jurjan AmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHPAEC were treated with either siRNA to SOX17 or CRISPR activating or inhibiting the promoter or an enhancer region associated with pulmonary hypertension and sequenced.
Source: GEO: Gene Expression Omnibus - July 10, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

'Exciting' siRNA Therapy for Hypertension Passes First Hurdle
(MedPage Today) -- Patients with hypertension successfully dialed down their angiotensinogen levels and had lasting reductions in blood pressure (BP) following one injection of an investigational small interfering RNA (siRNA) therapy, according...
Source: MedPage Today Cardiovascular - July 19, 2023 Category: Cardiology Source Type: news

Title: Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells
Conclusions: Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome. Citation: Whirledge S, Senbanjo LT, Cidlowski JA. 2015. Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect 123:80–87; http://dx.doi.org/10.1289/ehp.1408437 Address correspondence to J.A. Cidlowski, NIH/NIEHS, MD F3-07, P.O. Box 12233, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-1564. E-mail: cidlows1@niehs.nih.gov We thank X. Xu (Integrative Bioinformatic...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Research Article January 2015 Source Type: research

Abstract P310: Atuplex Formulated With Small Interfering RNA For Soluble Fms-like Tyrosine Kinase-1 (sFLT1) Selectively Silences Maternal And Placental sFLT1 In A Preeclamptic Rat Model Session Title: Pregnancy and Preeclampsia and Developmental Programming of Cardiovascular Disease
Preeclampsia is a pregnancy-related disorder characterized by hypertension and proteinuria, affecting about 5-8% of pregnancies. It is a major cause of fetal and maternal morbidity/mortality. The disease is most probably multifactorial and caused by several placental dysfunctions. As an important mediator, sFLT1 is induced in the placenta and in the serum of preeclamptic women, acting as a decoy receptor for placenta like growth factors (PLGF) and inducing an antiangiogenic balance. RNAi mediated gene specific silencing could represent a new therapeutic option in preeclampsia management. We tested sFLT1-specific small inte...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Nadine Haase, Kristin Kraker, Ute Schaeper, Jens Endruschat, Dominik N Muller, Ralf Dechend Tags: Poster Abstract Presentations Source Type: research

Estrogen Receptor-{beta} in the Paraventricular Nucleus and Rostroventrolateral Medulla Plays an Essential Protective Role in Aldosterone/Salt-Induced Hypertension in Female Rats Estrogen
The identification of the specific estrogen receptor (ER) subtypes that are involved in estrogen protection from hypertension and their specific locations in the central nervous system is critical to our understanding and design of effective estrogen replacement therapies in women. Using selective ER agonists and recombinant adeno-associated virus (AAV) carrying small interference (si) RNA to silence either ERα (AAV-siRNA-ERα) or ERβ (AAV-siRNA-ERβ), the present study investigated regional specificity of different ER subtypes in the protective actions of estrogen in aldosterone (Aldo)-induced hyperten...
Source: Hypertension - May 15, 2013 Category: Cardiology Authors: Xue, B., Zhang, Z., Beltz, T. G., Johnson, R. F., Guo, F., Hay, M., Johnson, A. K. Tags: Animal models of human disease, Other hypertension Estrogen Source Type: research

RNA silencing targeting PIN (protein inhibitor of neuronal nitric oxide synthase) attenuates the development of hypertension in young spontaneously hypertensive rats
Abstract: Nitric oxide (NO) deficiency contributes to hypertension. We previously showed that neuronal nitric oxide synthase (nNOS) was involved in hypertension and kidney damage in spontaneously hypertensive rats (SHRs). The protein inhibitor of nNOS (PIN) has been reported to inhibit activity of nNOS.Thus, we tested whether increased PIN in the kidney results in hypertension and whether small interfering RNA (siRNA) targeting PIN attenuates hypertension in SHRs. Four-week-old male SHRs were assigned into three groups (n = 6-7/group): SHR; SHR + PIN, SHR that received siRNA targeting PIN; and SHR + NC, SHR treated wit...
Source: Journal of the American Society of Hypertension - September 16, 2013 Category: Cardiology Authors: Su-Chen Wang, Kuan-Miao Lin, Shao-Ju Chien, Li-Tung Huang, Chien-Ning Hsu, You-Lin Tain Tags: Research Articles Source Type: research

Knockdown of mineralocorticoid or angiotensin II type 1 receptor gene expression in the paraventricular nucleus prevents angiotensin II hypertension in rats.
This article is protected by copyright. All rights reserved. PMID: 24973408 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - June 27, 2014 Category: Physiology Authors: Chen A, Huang BS, Wang HW, Ahmad M, Leenen FH Tags: J Physiol Source Type: research

Intrarenal ghrelin receptor inhibition ameliorates angiotensin ii-dependent hypertension in rats.
INTRARENAL GHRELIN RECEPTOR INHIBITION AMELIORATES ANGIOTENSIN II-DEPENDENT HYPERTENSION IN RATS. Am J Physiol Renal Physiol. 2018 Jun 20;: Authors: Kemp BA, Howell NL, Padia SH Abstract The intrarenal ghrelin receptor (GR) is localized to collecting duct (CD) cells where it increases αENaC-dependent sodium reabsorption in rodents. We hypothesized that chronic GR inhibition with intrarenal GR siRNA lowers blood pressure (BP) in Angiotensin II-dependent hypertension via reductions in αENaC-dependent sodium reabsorption. Uninephrectomized Sprague-Dawley rats (N=121) received subcutaneous osmotic pumps...
Source: Am J Physiol Renal P... - June 20, 2018 Category: Urology & Nephrology Authors: Kemp BA, Howell NL, Padia SH Tags: Am J Physiol Renal Physiol Source Type: research

Abstract P192: Both Mineralocorticoid Receptor and Angiotensin II type 1 Receptors in the Subfornical Organ Mediate Angiotensin II Induced Reactive Oxygen Species (ROS) in Brain Angiotensinergic Pathways Session Title: Neurogenic Mechanisms
Activation of angiotensinergic pathways and central aldosterone (aldo)-MR-ENaC-endogenous ouabain (EO)-AT1R pathway play a critical role in Ang II associated hypertension. The SFO contains both MR and AT1R and can relay the signals of circulating Ang II to downstream nuclei such as the PVN, SON and RVLM. We evaluated the effect of knockdown of MR and AT1R specific in the SFO on reactive oxygen species (ROS) production in downstream nuclei. Wistar rats were intra SFO infused with AAV-MR- or AT1aR-siRNA and after 7 days received a sc infusion of Ang II at 500 ng/min/kg for 2 weeks. MR and AT1R expression were measured by rea...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Wang, H.-W., White, R., Huang, B. S., Chen, A., Ahmad, M., Leenen, F. H. Tags: Session Title: Neurogenic Mechanisms Source Type: research

Abstract 154: Knockdown of Mineralocorticoid or AT1 Receptor Gene in the Paraventricular Nucleus Prevents Ang II Induced Hypertension in Rats Poster Session I
Circulating Ang II activates an aldosterone-MR-AT1R pathway in the hypothalamus. To obtain insights into the actual aldosterone-MR- AT1R neuronal pathway, the present study examined whether intra-PVN infusion of AAV-AT1aR-siRNA or AAV-MR-siRNA prevents the Ang II induced increases in AT1R and MR expression and BP. Two weeks sc infusion of Ang II at 500ng/kg/min in Wistar rats on regular salt diet increased BP by telemetry by 66 ± 3 mm Hg, and AT1R and MR protein in the SFO, SON and PVN. Intra-PVN AT1aR-siRNA decreased AT1R but not MR expression in the PVN by sc Ang II, and MR-siRNA decreased MR but not AT1R expressi...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Chen, A., Huang, B. S., Wang, H., Ahmad, M., Leenen, F. H. Tags: Poster Session I Source Type: research

Abstract 161: The (Pro)renin Receptor Regulates Renin Release and Prorenin-to-Renin Conversion in (Pro)Renin-Synthesizing Human Mast Cells Poster Session I
In conclusion, (P)RR knockdown affects both prorenin-renin conversion and (pro)renin release, resulting in a net rise of the renin/prorenin ratio in the medium.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Lu, X., Krop, M., Garrelds, I. M., van Gool, J. M., Jan Danser, A. H. Tags: Poster Session I Source Type: research

Hypoxia ‐induced microRNA‐26b inhibition contributes to hypoxic pulmonary hypertension via CTGF
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - August 17, 2017 Category: Biochemistry Authors: Sijing Zhou, Li Sun, Chao Cao, Peipei Wu, Min Li, Gengyun Sun, Guanghe Fei, Xing Ding, Ran Wang Tags: Article Source Type: research