Title: Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells

Conclusions: Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome.

Citation: Whirledge S, Senbanjo LT, Cidlowski JA. 2015. Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect 123:80–87; http://dx.doi.org/10.1289/ehp.1408437
Address correspondence to J.A. Cidlowski, NIH/NIEHS, MD F3-07, P.O. Box 12233, Research Triangle Park, NC 27709 USA. Telephone: [phone]. E-mail: [e-mail]
We thank X. Xu (Integrative Bioinformatics Program, NIEHS) for help with preparation of the heat map analysis.
This research was supported by the Intramural Research Program of the NIEHS, NIH.
The authors declare they have no actual or potential competing financial interests.
Received: 18 March 2013
Accepted: 15 August 2014
Advance Publication: 19 August 2014
Final Publication: 1 January 2015
Supplemental Material (515 KB) PDF

Introduction
Environmental compounds with estrogenic activity, present in plant constituents, plastics, and pesticides, are recognized endocrine disruptors, leading to impaired reproductive function in a number of species (Caserta et al. 2008). Some of these compounds display a structure similar to that of the natural ligand and are able to physically interact with the estrogen receptors (ER), mimicking the activity of estradiol (E2) (Gray...

Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Research Article January 2015 Source Type: research