miR ‐203 accelerates apoptosis and inflammation induced by LPS via targeting NFIL3 in cardiomyocytes
1. LPS induced the expression of miR ‐203 in H9c2 cells. 2. MiR‐203 promoted apoptosis and inflammatory responses induced by LPS. 3. Knockdown of nuclear factor interleukin‐3 (NFIL3) partly abrogated cardiac protective function of miR‐203. AbstractMyocarditis is an inflammatory disease of the myocardium. MicroRNA ‐203 (miR‐203) is involved in various physiological and pathological processes. In this work, we aimed to explore the roles and potential mechanisms of miR‐203 in myocarditis in vitro. Cardiomyocyte H9c2 was subjected to 10 μg/mL lipopolysaccharide (LPS) for 24 hours. Real‐time polymera se cha...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Yang Li, Xiping Liu, Aolin Du, Xiaolong Zhu, Bo Yu Tags: RESEARCH ARTICLE Source Type: research

MyD88 overexpression deteriorates Ang ‐II‐induced ED via upregulating MPO and COX2 and downregulating eNOS in the corpus cavernosum of rats
ConclusionMyD88 overexpression deteriorates Ang ‐II‐induced ED via upregulating MPO and COX2 and downregulating eNOS in the corpus cavernosum rats. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Haishan Zhang, Shujuan Zhang, Linpei Jia, Hai Li Tags: RESEARCH ARTICLE Source Type: research

MicroRNA ‐338‐3p inhibits tumor growth and metastasis in osteosarcoma cells by targeting RUNX2/CDK4 and inhibition of MAPK pathway
This study aimed to explore the roles of miR ‐338‐3p in OS and investigate the underlying mechanism. Human OS cell lines (MG‐63 and U2OS) and osteoblast (hFOB) cell line were used in the study. The expression levels of miR‐338‐3p, runt‐related transcription factor 2 (RUNX2) and cyclin‐dependent kinase 4 (CDK4) were altered by tra nsient transfection and determined by quantitative real‐time polymerase chain reaction/Western blot analysis. Cell viability, colony numbers, migration, and invasion, and apoptotic cells were measured by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT)...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Feng Jia, Zhen Zhang, Xu Zhang Tags: RESEARCH ARTICLE Source Type: research

LincRNA ‐p21 enhances the sensitivity of radiotherapy for gastric cancer by targeting the β‐catenin signaling pathway
In this study, we evaluated the role of lincRNA ‐p21 in the gastric cancer (GC). We demonstrated that the expression level of lincRNA‐p21 was downregulated in the GC tissues and cell lines. Moreover, ectopic expression of lincRNA‐p21 suppressed the GC cell growth, cell cycle, and migration. Furthermore, we demonstrated that the X‐ray incr eased the expression level of lincRNA‐p21 in both the HCG‐27 and SGC7901 cells and elevated expression of lincRNA‐p21 increased the radiotherapy sensitivity of the GC cell. In addition, we showed that ectopic expression of lincRNA‐p21 suppressed the β‐catenin and c‐my...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Lijun Chen, Dongfang Yuan, Yichen Yang, Minzhu Ren Tags: RESEARCH ARTICLE Source Type: research

Dual actions of the antioxidant chlorophyllin, a glutathione transferase P1 ‐1 inhibitor, in tumorigenesis and tumor progression
Chlorophyllin displayed genoprotective effects that can initially delay tumorigenesis; however, once the tumors are established, it may act as a promoter that facilitates tumor growth, potentially by a mechanism independent of cell proliferation and viability. Our results underline the pros and cons of antioxidant treatment in cancer, even if it has a capacity to inhibit GST enzyme. AbstractGlutathione (GSH) and enzymes related to this antioxidant molecule are often overexpressed in tumor cells and may contribute to drug resistance. Blockade of glutathione transferases (GSTs) has been proposed to potentiate the efficacy of...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Mehmet Ozcan, Gunes Esendagli, Yaman Musdal, Hande Canpinar, Merve Bacanl ı, Hatice Gul Anlar, Güldal Esendağlı‐Yılmaz, Mojtaba Beyramzadeh, Yasemin Aksoy Tags: RESEARCH ARTICLE Source Type: research

The effect of long noncoding RNAs HOX transcript antisense intergenic RNA single ‐nucleotide polymorphisms on breast cancer, cervical cancer, and ovarian cancer susceptibility: A meta‐analysis
HOX transcript antisense intergenic RNA (HOTAIR) rs4759314 increased susceptibility to breast cancer (BC), cervical cancer (CC), and ovarian cancer (OC) in some patients, and rs029778 and rs1899663 also increased susceptibility to some extent. Three functional polymorphisms, rs12826786, rs7958904, and rs874945, were not correlated with an effect on patient susceptibility to BC, CC, and OC. AbstractRecent studies have shown that long noncoding RNAs (lncRNA) HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility. The greatest threat to women ’s health among a variety of ca...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Jia Li, Ruijuan Liu, Shifeng Tang, Fubin Feng, Xue Wang, Lingyu Qi, Cun Liu, Yan Yao, Changgang Sun Tags: RESEARCH ARTICLE Source Type: research

Using a panel of multiple tumor ‐associated antigens to enhance the autoantibody detection in the immunodiagnosis of ovarian cancer
ConclusionsIn summary, the current study further supports that a customized TAA panel can serve as a promising and powerful tool for immunodiagnosis of OC and may be particularly useful in patients with normal CA125 levels. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Peng Wang, Jiejie Qin, Hua Ye, Liuxia Li, Xiao Wang, Jianying Zhang Tags: RESEARCH ARTICLE Source Type: research

LncRNA MALAT1 promotes oxidized low ‐density lipoprotein‐induced autophagy in HUVECs by inhibiting the PI3K/AKT pathway
In this study, we observed that autophagy was upregulated and MALAT1 expression was markedly increased in HUVECs treated with ox‐LDL. The ox‐LDL‐induced autophagy of HUVECs is significantly associated with the PI3K/AKT pathway. Fur thermore, we found that MALAT1 overexpression inhibited PI3K, Akt and p70S6K phosphorylation and downregulated RHEB expression, simultaneously increasing ox‐LDL‐induced autophagy. MALAT1 silencing caused higher phosphorylated PI3K, Akt and p70S6K levels, upregulated RHEB expression and markedly suppressed autophagy. These results indicated that lncRNA MALAT1 promotes ox‐LDL‐induced...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Shu Li, Xudong Pan, Shaonan Yang, Aijun Ma, Shuangshuang Yin, Yi Dong, Haotian Pei, Xinran Bi, Wei Li Tags: RESEARCH ARTICLE Source Type: research

The comparative study of the effects of Fe2O3 and TiO2 micro ‐ and nanoparticles on oxidative states of lung and bone marrow tissues and colony stimulating factor secretion
AbstractNowadays, increased use of nanomaterials in industry and biomedicine poses potential risks to human health and the environment. Studying their possible toxicological effects is therefore of great significance. The present investigation was designed to examine the status of oxidative stress induced by nanoparticles (NPs) of ferric oxide (Fe2O3) and titanium oxide (TiO2) with their micro ‐sized counterpart on mouse lung and bone marrow–derived normal tissue cells. We assessed the induction of oxidative stress by measuring its indicators such as antioxidant scavenging activity of superoxide dismutase and catalase ...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Arash Soltani, Kolsoum Rezaie Kahkhaie, Saeed Mohammadian Haftcheshmeh, Ahmad Ali Jalali Nezhad, Masoud Mashhadi Akbar Boojar Tags: RESEARCH ARTICLE Source Type: research

Expression of circulating miR ‐17, miR‐25, and miR‐133 in breast cancer patients
This study aimed to investigate some miRNAs in the serum of patients with breast cancer compared with the control group. Total RNA was extracted from the serum of patients with breast cancer and healthy volunteers. The expression levels of miRNAs and the genes were assessed using real ‐time reverse transcriptase‐polymerase chain reaction with specific primers. Our data showed that miR‐25 and miR‐133 were downregulated, and miR‐17 was upregulated in patients with breast cancer. Upregulation of miR‐17 is related to the poor survival time and increased cell proliferation . The reduced expression of miR‐133 and m...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: AmirReza Hesari, Mitra Azizian, Hassan Darabi, Abolfazl Nesaei, Seyede Atefe Hosseini, Reza Salarinia, Amir Ali Motaghi, Faezeh Ghasemi Tags: RESEARCH ARTICLE Source Type: research

miR ‐145 is a potential biomarker for predicting clinical outcome in glioblastomas
In this study, a retrospective study was conducted in 86 cases of patients with glioblastoma after neurosurgery combined with chemoradiotherapy, and 36 cases with traumatic brain injury. Our results showed that miR‐145 was significantly lower in glioblastoma tissues th an that in normal brain tissue (P <  0.05). Furthermore, miR‐145 was lower in patients with lower Karnofsky Performance Scale (KPS) scores than in patients with higher KPS scores (P <  0.05). Cox Regression analysis showed that low miR‐145 expression was associated with poor patient survival (P <  0.05). These data suggested that p...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Lei Shi, Bin Wang, Xiaoyan Gu, Shuguang Zhang, Xiaoliang Li, Haifeng Zhu Tags: RESEARCH ARTICLE Source Type: research

Gold nanoparticle and polyethylene glycol in neural regeneration in the treatment of neurodegenerative diseases
AbstractGold nanoparticles (GNs) have unique characteristics, for example, stability, biocompatibility, small dimensions, and low toxicity. Several clinical applications have been suggested for GNs, such as diagnosis, imaging, and drug delivery. GNs absorb infrared light, indicating their potential value for imaging. There is growing evidence showing the therapeutic application of GN for drug delivery because of their interaction with the blood ‐brain barrier and DNA, the latter being associated with their genotoxic effects. GN can also be stimulated to produce high local temperatures, indicating their potential value in...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Tayebe Aghaie, Mir Hadi Jazayeri, Mostafa Manian, leila Khani, Marjan Erfani, Majid Rezayi, Gordon A. Ferns, Amir Avan Tags: REVIEW Source Type: research

USP28 contributes to the proliferation and metastasis of gastric cancer
1.USP28 was found to be overexpressed in gastric cancer compared with normal gastric tissues. 2.Overexpression of USP28 was related to the degree of differentiation and metastases. 3.Inhibiting USP28 expression in vitro suppressed the proliferation and invasion of gastric cancer cells by downregulating lysine specific demethylase 1 (LSD1). AbstractUSP28, a member of the deubiquitinating enzymes family, plays a vital role in the physiological process of cell proliferation, differentiation and apoptosis, DNA repair, immune response, and stress response. USP28 has been reported to be overexpressed in bladder cancer, colon can...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Li ‐Juan Zhao, Ting Zhang, Xue‐Jian Feng, Jiao Chang, Feng‐Zhi Suo, Jin‐Lian Ma, Ying‐Jun Liu, Ying Liu, Yi‐Chao Zheng, Hong‐Min Liu Tags: RESEARCH ARTICLE Source Type: research

Analysis of long noncoding RNA expression profiles in the whole blood of neonates with hypoxic ‐ischemic encephalopathy
In conclusion, our study first demonstrated the differential expression profiles of lncRNAs in the whole blood of infants with HIE and may provide a new view of the distinct lncRNA functions in HIE. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Xiaohua Dong, Yingmin Zhao, Yun Huang, Lingling Yu, Xiaojing Yang, Feng Gao Tags: RESEARCH ARTICLE Source Type: research

MicroRNA ‐34a inhibit hepatocellular carcinoma progression by repressing hexokinase‐1
The current study demonstrated that upregulation of microRNA ‐34a (miR‐34a) restrained viability and proliferation capacity of hepatocellular carcinoma (HCC) cells, as well as tumorigenesis via downregulating hexokinase (HK)‐1 in vivo. The results may provide novel insights into the molecular mechanism of miR‐34a and HK1 in the progression of HCC. Thu s, miR‐34a/HK1 axis might be a novel promising therapeutic target for treating HCC. AbstractHepatocellular carcinoma (HCC) is known as a frequent type of primary cancer in the liver, and it is the third ‐most common cause of cancer‐related death all over the wor...
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Yitong Zhou, Kai Liu, Yahui Liu, Ludong Tan Tags: RESEARCH ARTICLE Source Type: research