miR ‐203 accelerates apoptosis and inflammation induced by LPS via targeting NFIL3 in cardiomyocytes
1. LPS induced the expression of miR ‐203 in H9c2 cells. 2. MiR‐203 promoted apoptosis and inflammatory responses induced by LPS. 3. Knockdown of nuclear factor interleukin‐3 (NFIL3) partly abrogated cardiac protective function of miR‐203. AbstractMyocarditis is an inflammatory disease of the myocardium. MicroRNA ‐203 (miR‐203) is involved in various physiological and pathological processes. In this work, we aimed to explore the roles and potential mechanisms of miR‐203 in myocarditis in vitro. Cardiomyocyte H9c2 was subjected to 10 μg/mL lipopolysaccharide (LPS) for 24 hours. Real‐time pol...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Yang Li, Xiping Liu, Aolin Du, Xiaolong Zhu, Bo Yu Tags: RESEARCH ARTICLE Source Type: research

MyD88 overexpression deteriorates Ang ‐II‐induced ED via upregulating MPO and COX2 and downregulating eNOS in the corpus cavernosum of rats
ConclusionMyD88 overexpression deteriorates Ang ‐II‐induced ED via upregulating MPO and COX2 and downregulating eNOS in the corpus cavernosum rats. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Haishan Zhang, Shujuan Zhang, Linpei Jia, Hai Li Tags: RESEARCH ARTICLE Source Type: research

MicroRNA ‐338‐3p inhibits tumor growth and metastasis in osteosarcoma cells by targeting RUNX2/CDK4 and inhibition of MAPK pathway
This study aimed to explore the roles of miR ‐338‐3p in OS and investigate the underlying mechanism. Human OS cell lines (MG‐63 and U2OS) and osteoblast (hFOB) cell line were used in the study. The expression levels of miR‐338‐3p, runt‐related transcription factor 2 (RUNX2) and cyclin‐dependent kinase 4 (CDK4) were altered by tra nsient transfection and determined by quantitative real‐time polymerase chain reaction/Western blot analysis. Cell viability, colony numbers, migration, and invasion, and apoptotic cells were measured by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT)...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Feng Jia, Zhen Zhang, Xu Zhang Tags: RESEARCH ARTICLE Source Type: research

LincRNA ‐p21 enhances the sensitivity of radiotherapy for gastric cancer by targeting the β‐catenin signaling pathway
In this study, we evaluated the role of lincRNA ‐p21 in the gastric cancer (GC). We demonstrated that the expression level of lincRNA‐p21 was downregulated in the GC tissues and cell lines. Moreover, ectopic expression of lincRNA‐p21 suppressed the GC cell growth, cell cycle, and migration. Furthermore, we demonstrated that the X‐ray incr eased the expression level of lincRNA‐p21 in both the HCG‐27 and SGC7901 cells and elevated expression of lincRNA‐p21 increased the radiotherapy sensitivity of the GC cell. In addition, we showed that ectopic expression of lincRNA‐p21 suppressed the β‐catenin and c...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Lijun Chen, Dongfang Yuan, Yichen Yang, Minzhu Ren Tags: RESEARCH ARTICLE Source Type: research

Dual actions of the antioxidant chlorophyllin, a glutathione transferase P1 ‐1 inhibitor, in tumorigenesis and tumor progression
Chlorophyllin displayed genoprotective effects that can initially delay tumorigenesis; however, once the tumors are established, it may act as a promoter that facilitates tumor growth, potentially by a mechanism independent of cell proliferation and viability. Our results underline the pros and cons of antioxidant treatment in cancer, even if it has a capacity to inhibit GST enzyme. AbstractGlutathione (GSH) and enzymes related to this antioxidant molecule are often overexpressed in tumor cells and may contribute to drug resistance. Blockade of glutathione transferases (GSTs) has been proposed to potentiate the efficacy of...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Mehmet Ozcan, Gunes Esendagli, Yaman Musdal, Hande Canpinar, Merve Bacanl ı, Hatice Gul Anlar, Güldal Esendağlı‐Yılmaz, Mojtaba Beyramzadeh, Yasemin Aksoy Tags: RESEARCH ARTICLE Source Type: research

The effect of long noncoding RNAs HOX transcript antisense intergenic RNA single ‐nucleotide polymorphisms on breast cancer, cervical cancer, and ovarian cancer susceptibility: A meta‐analysis
HOX transcript antisense intergenic RNA (HOTAIR) rs4759314 increased susceptibility to breast cancer (BC), cervical cancer (CC), and ovarian cancer (OC) in some patients, and rs029778 and rs1899663 also increased susceptibility to some extent. Three functional polymorphisms, rs12826786, rs7958904, and rs874945, were not correlated with an effect on patient susceptibility to BC, CC, and OC. AbstractRecent studies have shown that long noncoding RNAs (lncRNA) HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility. The greatest threat to women ’s health among a varie...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Jia Li, Ruijuan Liu, Shifeng Tang, Fubin Feng, Xue Wang, Lingyu Qi, Cun Liu, Yan Yao, Changgang Sun Tags: RESEARCH ARTICLE Source Type: research

Using a panel of multiple tumor ‐associated antigens to enhance the autoantibody detection in the immunodiagnosis of ovarian cancer
In summary, the current study further suggested that a panel of tumor ‐associated antigens (TAAs) could enhance antibody detection in immunodiagnosis of ovarian cancer (OC). The data in this study showed that TAAs panel might be a novel noninvasive approach to distinguish OC from normal individuals. We conclude that multiple anti‐TAAs antibody detections may impro ve the diagnostic value of OC. AbstractBackgroundOvarian cancer (OC) is a major malignancy affecting a large population over the world, and a biomarker that holds diagnostic potential is of critical importance. Recently, autoantibodies have been indicated as ...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Peng Wang, Jiejie Qin, Hua Ye, Liuxia Li, Xiao Wang, Jianying Zhang Tags: RESEARCH ARTICLE Source Type: research

LncRNA MALAT1 promotes oxidized low ‐density lipoprotein‐induced autophagy in HUVECs by inhibiting the PI3K/AKT pathway
In this study, we observed that autophagy was upregulated and MALAT1 expression was markedly increased in HUVECs treated with ox‐LDL. The ox‐LDL‐induced autophagy of HUVECs is significantly associated with the PI3K/AKT pathway. Fur thermore, we found that MALAT1 overexpression inhibited PI3K, Akt and p70S6K phosphorylation and downregulated RHEB expression, simultaneously increasing ox‐LDL‐induced autophagy. MALAT1 silencing caused higher phosphorylated PI3K, Akt and p70S6K levels, upregulated RHEB expression and markedly suppressed autophagy. These results indicated that lncRNA MALAT1 promotes ox‐LDL‐induced...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Shu Li, Xudong Pan, Shaonan Yang, Aijun Ma, Shuangshuang Yin, Yi Dong, Haotian Pei, Xinran Bi, Wei Li Tags: RESEARCH ARTICLE Source Type: research

The comparative study of the effects of Fe2O3 and TiO2 micro ‐ and nanoparticles on oxidative states of lung and bone marrow tissues and colony stimulating factor secretion
AbstractNowadays, increased use of nanomaterials in industry and biomedicine poses potential risks to human health and the environment. Studying their possible toxicological effects is therefore of great significance. The present investigation was designed to examine the status of oxidative stress induced by nanoparticles (NPs) of ferric oxide (Fe2O3) and titanium oxide (TiO2) with their micro ‐sized counterpart on mouse lung and bone marrow–derived normal tissue cells. We assessed the induction of oxidative stress by measuring its indicators such as antioxidant scavenging activity of superoxide dismutase and catal...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Arash Soltani, Kolsoum Rezaie Kahkhaie, Saeed Mohammadian Haftcheshmeh, Ahmad Ali Jalali Nezhad, Masoud Mashhadi Akbar Boojar Tags: RESEARCH ARTICLE Source Type: research

Expression of circulating miR ‐17, miR‐25, and miR‐133 in breast cancer patients
This study aimed to investigate some miRNAs in the serum of patients with breast cancer compared with the control group. Total RNA was extracted from the serum of patients with breast cancer and healthy volunteers. The expression levels of miRNAs and the genes were assessed using real ‐time reverse transcriptase‐polymerase chain reaction with specific primers. Our data showed that miR‐25 and miR‐133 were downregulated, and miR‐17 was upregulated in patients with breast cancer. Upregulation of miR‐17 is related to the poor survival time and increased cell proliferation . The reduced expression of miR‐133 and m...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: AmirReza Hesari, Mitra Azizian, Hassan Darabi, Abolfazl Nesaei, Seyede Atefe Hosseini, Reza Salarinia, Amir Ali Motaghi, Faezeh Ghasemi Tags: RESEARCH ARTICLE Source Type: research

miR ‐145 is a potential biomarker for predicting clinical outcome in glioblastomas
In this study, a retrospective study was conducted in 86 cases of patients with glioblastoma after neurosurgery combined with chemoradiotherapy, and 36 cases with traumatic brain injury. Our results showed that miR‐145 was significantly lower in glioblastoma tissues th an that in normal brain tissue (P 
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Lei Shi, Bin Wang, Xiaoyan Gu, Shuguang Zhang, Xiaoliang Li, Haifeng Zhu Tags: RESEARCH ARTICLE Source Type: research

Gold nanoparticle and polyethylene glycol in neural regeneration in the treatment of neurodegenerative diseases
AbstractGold nanoparticles (GNs) have unique characteristics, for example, stability, biocompatibility, small dimensions, and low toxicity. Several clinical applications have been suggested for GNs, such as diagnosis, imaging, and drug delivery. GNs absorb infrared light, indicating their potential value for imaging. There is growing evidence showing the therapeutic application of GN for drug delivery because of their interaction with the blood ‐brain barrier and DNA, the latter being associated with their genotoxic effects. GN can also be stimulated to produce high local temperatures, indicating their potential value in...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Tayebe Aghaie, Mir Hadi Jazayeri, Mostafa Manian, leila Khani, Marjan Erfani, Majid Rezayi, Gordon A. Ferns, Amir Avan Tags: REVIEW Source Type: research

USP28 contributes to the proliferation and metastasis of gastric cancer
1.USP28 was found to be overexpressed in gastric cancer compared with normal gastric tissues. 2.Overexpression of USP28 was related to the degree of differentiation and metastases. 3.Inhibiting USP28 expression in vitro suppressed the proliferation and invasion of gastric cancer cells by downregulating lysine specific demethylase 1 (LSD1). AbstractUSP28, a member of the deubiquitinating enzymes family, plays a vital role in the physiological process of cell proliferation, differentiation and apoptosis, DNA repair, immune response, and stress response. USP28 has been reported to be overexpressed in bladder cancer, colon can...
Source: Journal of Cellular Biochemistry - November 28, 2018 Category: Biochemistry Authors: Li ‐Juan Zhao, Ting Zhang, Xue‐Jian Feng, Jiao Chang, Feng‐Zhi Suo, Jin‐Lian Ma, Ying‐Jun Liu, Ying Liu, Yi‐Chao Zheng, Hong‐Min Liu Tags: RESEARCH ARTICLE Source Type: research

Analysis of long noncoding RNA expression profiles in the whole blood of neonates with hypoxic ‐ischemic encephalopathy
In conclusion, our study first demonstrated the differential expression profiles of lncRNAs in the whole blood of infants with HIE and may provide a new view of the distinct lncRNA functions in HIE. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Xiaohua Dong, Yingmin Zhao, Yun Huang, Lingling Yu, Xiaojing Yang, Feng Gao Tags: RESEARCH ARTICLE Source Type: research

MicroRNA ‐34a inhibit hepatocellular carcinoma progression by repressing hexokinase‐1
The current study demonstrated that upregulation of microRNA ‐34a (miR‐34a) restrained viability and proliferation capacity of hepatocellular carcinoma (HCC) cells, as well as tumorigenesis via downregulating hexokinase (HK)‐1 in vivo. The results may provide novel insights into the molecular mechanism of miR‐34a and HK1 in the progression of HCC. Thu s, miR‐34a/HK1 axis might be a novel promising therapeutic target for treating HCC. AbstractHepatocellular carcinoma (HCC) is known as a frequent type of primary cancer in the liver, and it is the third ‐most common cause of cancer‐related death all over the wor...
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Yitong Zhou, Kai Liu, Yahui Liu, Ludong Tan Tags: RESEARCH ARTICLE Source Type: research

Effect of sodium ‐glucose cotransporter 2 inhibitor, empagliflozin, and α‐glucosidase inhibitor, voglibose, on hepatic steatosis in an animal model of type 2 diabetes
ConclusionWe suggest that this metabolic improvement might be related to SIRT1 and AMPK pathway in T2DM. But empagliflozin is thought to have more advantage to prevent hepatic steatosis than voglibose in T2DM. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Ji ‐Won Kim, Ye‐Jee Lee, Young‐Hye You, Min Kyong Moon, Kun‐Ho Yoon, Yu‐Bae Ahn, Seung‐Hyun Ko Tags: RESEARCH ARTICLE Source Type: research

Shen ’ge powder decreases the cardiomyocyte hypertrophy in chronic heart failure by activating the Rho protein/Rho‐associated coiledcoil forming protein kinase signaling pathway
ConclusionShen ’ge powder could reduce cardiomyocyte hypertrophy in CHF by regulating the Rho/ROCK signaling pathway. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Xinpeng Yan, Kai Jiao, Xiaozheng Song Tags: RESEARCH ARTICLE Source Type: research

Efficacy of Chinese herb Cistanche Yishen granules in treatment of tinnitus for patients with chronic nephritis
ConclusionCYG could apparently release the tinnitus symptoms in the patients with chronic nephritis. This study might give more clinical evidence for Cistanche in the treatment of tinnitus and give a new treatment method for the patients with tinnitus. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Xiaoli Fan, Yue Chen, Li Li, Yang Wang, Yi Zhang, Shan Lu, Danyang Zhu, Meixiao Sheng Tags: RESEARCH ARTICLE Source Type: research

Identification of NPAC as a novel biomarker and regulator for hepatocellular carcinoma
ConclusionsThese results suggest that NPAC may play an important role in the development and progression of HCC, and can act as a novel potential prognostic biomarker and therapeutic target for HCC. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Jiecheng Zhang, Nannan Sun, Wenfeng Guo, Xiaojie Wu, Xiaoying Yang, Haiyong Jin, Yueling Zhang, Xiaoting Wu, Fenglian Zhang, Ling Hu, Huiling Hu, Yong Gao Tags: RESEARCH ARTICLE Source Type: research

The interaction between ANXA2 and lncRNA Fendrr promotes cell apoptosis in caerulein ‐induced acute pancreatitis
ConclusionOur study demonstrated that ANXA2 promoted AP progression via interacting with lncRNA Fendrr in vitro, which will provide a novel insight into the therapeutic target for AP. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Dali Zhao, Huajun Ge, Biao Ma, Dongbo Xue, Weihui Zhang, Zhituo Li, Haijun Sun Tags: RESEARCH ARTICLE Source Type: research

Virtual screening of National Cancer Institute database for claudin ‐4 inhibitors: Synthesis, biological evaluation, and molecular dynamics studies
In the present work, structure ‐based virtual screening is performed with the National Cancer Institute (NCI) database using Glide. Molecular dynamics simulations of membrane protein were used for optimization of the top‐three lead compounds (NCI110039, NCI344682, and NCI661251) with claudin‐4 in a dynamic system. Synthesis of the NCI110039 was performed. Cytotoxicity assays proved that purpurogallin carboxylic acid has the inhibitory effect towards breast (MCF7) and lung (A549) cancer cell lines. AbstractClaudin ‐4 (CLDN4) is a vital member of tight‐junction proteins that is often overexpressed in cancer and oth...
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Majji Rambabu, Sivaraman Jayanthi Tags: RESEARCH ARTICLE Source Type: research

Disorders in NADPH generation via pentose phosphate pathway influence the reproductive potential of the Saccharomyces cerevisiae yeast due to changes in redox status
In this study, we examine the impact of redox homoeostasis on cellular physiology and proliferation. We have noted that the Δzwf1 mutant lacking the rate ‐limiting enzyme of the PP pathway shows changes in the cellular redox status caused by disorders in NADPH generation. This leads to a decrease in reproductive potential but without affecting the total lifespan of the cell. The results presented in this paper show that nicotine adenine dinucleotid es play a central role in cellular physiology. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Magdalena Kwolek ‐Mirek, Roman Maslanka, Mateusz Molon Tags: RESEARCH ARTICLE Source Type: research

Long noncoding RNA POU3F3 promotes cancer cell proliferation in prostate carcinoma by upregulating rho ‐associated protein kinase 1
In this study we found that POU3F3 and rho‐associated protein kinase 1 (ROCK1) were both increased in tumor tissues than in adjacent healthy tissues of patients with prostate carcinoma. Expression levels of POU3F3 increased with increase in the diameter of tumor but were not significantly affected by lymph node metastasis or distant metastasis. Expression levels of POU3F3 and ROCK1 were positive correlated in tumor tissues but not in adjacent healthy tissues. POU3F3 and ROCK1 overexpression promoted, while ROCK1 knockdown inhibited the proliferation of prostate carcinoma cells. ROCK1 knockdown reduced the enhancing effec...
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Xiaodong Wan, Jun Xiang, Qimin Zhang, Cuidong Bian Tags: RESEARCH ARTICLE Source Type: research

LncRNA C2dat1 enhances vascular smooth muscle cell proliferation and migration by targeting MiR ‐34a‐5p
In this study, we showed that the expression level of C2dat1 was higher in coronary artery disease (CAD) tissues than in normal arterial tissues and the C2dat1 expression level was upregulated in the prolif erating VSMC after being treated with PDGF‐bb or TNF‐α. In addition, we indicated that overexpression of C2dat1 promoted VSMC growth and enhanced PCNA expression in VSMC. Moreover, ectopic expression of C2dat1 increased VSMC migration. Furthermore, we showed that elevated expression of C2dat1 s uppressed miR‐34a expression and promoted sirtuin 1 (SIRT1) expression, which was a direct target gene of miR‐34a...
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Hairong Wang, Zhili Jin, Tu Pei, Wenhao Song, Yao Gong, Deliang Chen, Lin Zhang, Meichun Zhang, Gangchen Zhang Tags: RESEARCH ARTICLE Source Type: research

Chinese herbal decoction of Wenshen Yangxue formula improved fertility and pregnancy rate in mice through PI3K/Akt signaling
ConclusionThese results suggested the herbal decoctions promoted the fertilization of mice, which was related to the charge of PI3K/Akt activation. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Mingwei Xin, Junqin He, Ying Zhang, Ying Wu, Wei Yang, Xinyun Liang, Xiaodan Yin Tags: RESEARCH ARTICLE Source Type: research

Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells
This study focused on the antisenescence effect of four plant species (Falcaria vulgaris, Ixiolirion tataricum, Ajuga chamaecistus, andScabiosa flavida) on H2O2‐induced premature senescence in rat NIH3T3 fibroblasts, which were found to be rich in effective phytochemicals with traditional ethnobotanical backgrounds. Plant materials were collected, identified, and extracted. To determine the viability of NIH3T3 cells, an MTT assay was conducted. The level s of OS markers and the senescence‐associated ß‐galactosidase (SA‐ß‐GAL) activity were analyzed by the Elisa reader. The cell cycle pattern was evalu...
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Saeideh Momtaz, Maryam Baeeri, Mahban Rahimifard, Hamed Haghi ‐Aminjan, Shokoufeh Hassani, Mohammad Abdollahi Tags: RESEARCH ARTICLE Source Type: research

LncRNA H19/miR ‐194/PFTK1 axis modulates the cell proliferation and migration of pancreatic cancer
MiR ‐194 messenger RNA expression was dramatically downregulated in pancreatic ductal adenocarcinoma (PDAC) tissues, and was negatively correlated with long noncoding RNA (lncRNA) H19 and PFTK1, suggesting that rescuing miR‐194 expression in PDAC, therefore inhibiting lncRNA H19 and PFTK1, subsequen tly suppressing PDAC cell proliferation and migration might make contribution to the treatment of PDAC. AbstractPancreatic ductal adenocarcinoma (PDAC) remains a huge challenge due to its high mortality and morbidity; gene therapy might be a promising treatment for PDAC. The critical role of Wnt ‐signaling pathway in canc...
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Yunpeng Sun, Qiandong Zhu, Wenjun Yang, Yunfeng Shan, Zhengping Yu, Qiyu Zhang, Huanhuan Wu Tags: RESEARCH ARTICLE Source Type: research

Polycystins in disease mechanobiology
In this study, we highlight emerging data that support the overall contribution of polycystins to disease mechanobiology and suggest further exploration of this protein family in diseases generated from force‐bearing tissue structures. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Antonios N. Gargalionis, Efthimia K. Basdra, Athanasios G. Papavassiliou Tags: PROSPECTS Source Type: research

Kanamycin induces free radicals formation in melanocytes: An important factor for aminoglycosides ototoxicity
Previously we demonstrated that kanamycin disturbs homeostasis in light ‐pigmented melanocytes. To investigate if/how melanization contributes to this phenomenon, the study using in vitro model of dark‐pigmented melanocytes were performed. The obtained results were compared with data concerning light‐pigmented melanocytes and the role of melanin in the mechanism o f kanamycin‐induced hearing impairment was revealed. AbstractOtotoxicity is well ‐documented but not fully understood undesirable side effect of aminoglycoside antibiotic, kanamycin. Kanamycin is capable of binding to melanin biopolymers—natural p...
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Dorota Wrze śniok, Jakub Rok, Artur Beberok, Zuzanna Rzepka, Michalina Respondek, Barbara Pilawa, Magdalena Zdybel, Marcin Delijewski, Ewa Buszman Tags: RESEARCH ARTICLE Source Type: research

Cover Image, Volume 120, Number 1, January 2019
Cover: The cover image, by Dolati et al, is based on the Review Article,Mesenchymal stem cell and bone marrow mononuclear cell therapy for cardiomyopathy: From bench to bedside, DOI:10.1002/jcb.27531. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Sanam Dolati, Mehdi Yousefi, Mahdi Mahdipour, Abbas Afrasiabi Rad, Alireza Pishgahi, Mohammad Nouri, Ahmad Reza Jodati Tags: COVER Source Type: research

Issue Information
Journal of Cellular Biochemistry, Volume 120, Issue 1, Page 1-13, January 2019. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Optimizing methods for human testicular tissue cryopreservation and spermatogonial stem cell isolation
Cryopreservation of testicular tissue before cancer therapy for fertility preservation in prepubertal boys with cancer is of great interest in reproductive medicine. Isolation of spermatogonial stem cells (SSCs) from cryopreserved tissues would be a suitable cell source to re ‐establish spermatogenesis after cancer therapy. We herein establish optimized protocols for cryopreservation of human testicular tissue and isolation of SSCs from cryopreserved tissue. We developed a freezing protocol that provided high testicular cell viability and supported structural integrity and tubular epithelium coherence similar to fresh ti...
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Seyedeh ‐Faezeh Moraveji, Fereshteh Esfandiari, Mina Sharbatoghli, Sara Taleahmad, Saman Nikeghbalian, Abdolhossein Shahverdi, Hossein Baharvand Tags: RESEARCH ARTICLE Source Type: research

Esophageal cancer lymph node metastasis –associated gene signature optimizes overall survival prediction of esophageal cancer
In summary, the messenger RNA –based risk score model that we developed successfully predicts the survival of esophageal cancer. It is independent of clinical information and performs better than other clinical information for prognosis. AUC, area under the curve; CI, confidence interval. AbstractEsophageal cancer (EC) is characteristic of early regional lymph node metastasis (LNM) and most patients with metastasis have a poor prognosis. However, the current diagnostic techniques do not enable precise differentiation of EC LNM, prognostic stratification, and individual survival estimation. To identify potential molec...
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Weiyang Cai, Yanyan Li, Bo Huang, Changyuan Hu Tags: RESEARCH ARTICLE Source Type: research

Inhibitory role of lentivirus ‐mediated aquaporin‐4 gene silencing in the formation of glial scar in a rat model of traumatic brain injury
AbstractTraumatic brain injury (TBI), an acute degenerative pathology of the central nervous system, is a leading cause of death and disability. As the glial scar is a mechanical barrier to nerve regeneration, inhibitory molecules in the forming scar and methods to overcome them have suggested molecular modification strategies to allow neuronal growth and functional regeneration. Herein, we aim to investigate the effects of aquaporin ‐4 (AQP4) gene silencing on the glial scar formation after TBI by establishing rat models. After modeling, TBI rats were transfected with AQP4 small hairpin RNA [shRNA] (AQP4 gene silencing ...
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Ya ‐Xiong Yong, Yu‐Ming Li, Jia Lian, Chuan‐Ming Luo, De‐Xia Zhong, Ke Han Tags: RESEARCH ARTICLE Source Type: research

CRNDE promotes cell tongue squamous cell carcinoma cell growth and invasion through suppressing miR ‐384
1.Colorectal neoplasia differentially expressed (CRNDE) expression was upregulated in tongue squamous cell carcinoma (TSCC) cell lines and tissues. Overexpression of CRNDE increased the TSCC cell proliferation, cell cycle, and cell invasion. CRNDE promoted TSCC cell proliferation and invasion through inhibiting miR ‐384 expression. AbstractTongue squamous cell carcinoma (TSCC) is the most common type of oral cancer and is an aggressive head and neck malignancy. Increasing studies have demonstrated that long noncoding RNAs (lncRNAs) play important roles in diverse biological cell processes, such as cell development, fate ...
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Yixiong Ren, Wenting He, Wenge Chen, Chao Ma, Yun Li, Zhenyan Zhao, Tao Gao, Qianwei Ni, Juan Chai, Moyi Sun Tags: RESEARCH ARTICLE Source Type: research

Recent advances in endotoxin tolerance
AbstractEndotoxin tolerance is defined as a reduced capacity of a cell to respond endotoxin (lipopolysaccharide, LPS) challenge after an initial encounter with endotoxin in advance. The body becomes tolerant to subsequent challenge with a lethal dose of endotoxin and cytokines release and cell/tissue damage induced by inflammatory reaction are significantly reduced in the state of endotoxin tolerance. The main characteristics of endotoxin tolerance are downregulation of inflammatory mediators such as tumor necrosis factor α (TNF‐α), interleukin‐1β (IL‐1β), and C‐X‐C motif chemokine 10 (CXCL1...
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Dan Liu, Shousong Cao, Yejiang Zhou, Yuxia Xiong Tags: PROSPECTS Source Type: research

Whole transcriptome sequencing reveals biologically significant RNA markers and related regulating biological pathways in cardiomyocyte hypertrophy induced by high glucose
Our study gives new insights into cardiomyocyte hypertrophy and makes a great progress in comprehending its mechanism. AbstractCardiomyocyte hypertrophy is a physiological adaptation used in an attempt to augment or preserve cardiac function for short periods. Long ‐term cardiomyocyte hypertrophy often progresses to heart failure. Previous studies have presented comprehensive mechanisms underlying cardiomyocyte hypertrophy, such as signaling pathways, marker genes, and marker miRNAs or lncRNAs. However, the mechanism in RNA level is still unclear. In this st udy, we used the whole transcriptome technology on cardiomyocet...
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Zheying Meng, Cui Chen, Hongli Cao, Jingyi Wang, E Shen Tags: RESEARCH ARTICLE Source Type: research

Curcumin derivative L6H4 inhibits proliferation and invasion of gastric cancer cell line BGC ‐823
In this study, we investigated the anticancer activity of curcumin derivative L6H4 (curcumin L6H4) on gastric cancer cells. Inhibitory effects of curcumin L6H4 on gastric cancer cells (BGC‐823) were studied by the diphenyltetrazolium (MTT) assay, and cell apoptosis was detected by Annexin‐V/propidium iodide (PI) staining and then analyzed by flow cytometry. A mouse xenotransplant gastric tumor model was established to detect the role of curcumin L6H4 in vivo. The apoptosis‐related proteins p53, p21, Bax, and Bcl‐2 in BGC‐823 cells and mouse xenotransplant models treated with curcumin L6H4 were determined by Weste...
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Jianfeng Mu, Xiaodong Wang, Lihua Dong, Pengda Sun Tags: RESEARCH ARTICLE Source Type: research

Evaluation on the effect of hydrogen sulfide on the NLRP3 signaling pathway and its involvement in the pathogenesis of atherosclerosis
ConclusionIn summary, the present finding suggested a possible linkage between H2S metabolism and AS through the H2S/CSE ‐TXNIP‐NLRP3‐IL‐18/IL‐1β‐nitric oxide (NO) signaling pathway. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Li ‐Ming Yue, Ya‐Mei Gao, Bao‐Hua Han Tags: RESEARCH ARTICLE Source Type: research

Dexmedetomidine alleviates cerebral ischemia ‐reperfusion injury in rats via inhibition of hypoxia‐inducible factor‐1α
Dexmedetomidine (Dex) can reduce apoptosis induced by cerebral ischemia ‐reperfusion (I/R). Increased expression of hypoxia‐inducible factor‐1α (HIF‐1α) was found in brain tissue of I/R rats. Inhibition of HIF‐1α reduces apoptosis induced by I/R. AbstractDexmedetomidine (Dex) was reported to reduce ischemia ‐reperfusion (I/R) injury in kidney and brain tissues. Thus, we aimed to study the role and mechanism of Dex in cerebral I/R injury by inhibiting hypoxia‐inducible factor‐1α (HIF‐1α) and apoptosis. First, I/R injury models were established. Six groups were assigned after d...
Source: Journal of Cellular Biochemistry - November 19, 2018 Category: Biochemistry Authors: Yuan ‐Qing Wang, Yu‐Feng Tang, Ming‐Kun Yang, Xi‐Zhao Huang Tags: RESEARCH ARTICLE Source Type: research

LncRNA FOXD2 ‐AS1 accelerates the papillary thyroid cancer progression through regulating the miR‐485‐5p/KLK7 axis
This study aims to explore the biological role and mechanism of FOXD2‐AS1 in PTC. At first, the expression of FOXD2‐ AS1 was examined in PTC tissues and cell lines with quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR). FOXD2‐AS1 was found to observably upregulated in PTC tissues and cell lines. Kaplan‐Meier survival analysis revealed that high expression of FOXD2‐AS1 was closely cor related with the unfavorable prognosis of patients with PTC. Based on the TCGA data set, KLK7 was overexpressed in PTC tumor samples. Our experimental data further validated the upregulation of KLK7 in PTC ti...
Source: Journal of Cellular Biochemistry - November 19, 2018 Category: Biochemistry Authors: Yayuan Zhang, Jintao Hu, Wenbing Zhou, Hengyuan Gao Tags: RESEARCH ARTICLE Source Type: research

TMEM106A inhibits cell proliferation, migration, and induces apoptosis of lung cancer cells
In this study, we evaluated the expression profile of TMEM106A in NSCLC tissues and cell line, and explored the roles of TMEM106A in NSCLC cell lines. Our results showed that TMEM106A expression was significantly decreased in human NSCLC tiss ues. In vitro assays showed that TMEM106A expression in NSCLC cell lines was much lower than that in the bronchial epithelial cell line. Besides, overexpression of TMEM106A reduced cell proliferation, migration, and invasion, while induced cell apoptosis in NSCLC cells. TMEM106A overexpression repre ssed epithelial‐mesenchymal transition (EMT), which was illustrated by increased E...
Source: Journal of Cellular Biochemistry - November 19, 2018 Category: Biochemistry Authors: Juncai Liu, Hongjing Zhu Tags: RESEARCH ARTICLE Source Type: research

Oxymatrine ameliorates diabetes ‐induced aortic endothelial dysfunction via the regulation of eNOS and NOX4
ConclusionThe OMT treatment ameliorates diabetic endothelial dysfunction through enhanced NO bioavailability by upregulating eNOS expression and downregulating expression of NOX4. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 19, 2018 Category: Biochemistry Authors: Lei Wang, Xinliang Li, Yanqi Zhang, Yongpan Huang, Yinzhuang Zhang, Qilin Ma Tags: RESEARCH ARTICLE Source Type: research

Role of miR ‐142 in the pathogenesis of osteosarcoma and its potential as therapeutic approach
The current review aimed to have overview on miR ‐142 as a tumor suppressor in osteosarcoma (OS). Additionally, the genes involved in the disease, such as RAC1, HMAG1, MMP9, MMP2, and E‐cadherin, which have irregularities as a result of change in miR‐142 expression, and, thereby, result in increasing the proliferation, invasion, and metastas is of the tumor cells in OS will be discussed. AbstractOsteosarcoma (OS) is the most common primary malignant tumor of the bone with a strong tendency to early metastasis, and occurs in growing bones more commonly in children and adolescents. Considering the limited therapeutic m...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Parastoo Shabani, Sama Izadpanah, Ali Aghebati ‐Maleki, Elham Baghbani, Amir Baghbanzadeh, Ali Fotouhi, Babak Bakhshinejad, Leili Aghebati‐Maleki, Behzad Baradaran Tags: VIEW POINTS Source Type: research

Silencing of ADAM33 restrains proliferation and induces apoptosis of airway smooth muscle cells in ovalbumin ‐induced asthma model
Silencing of a disintegrin and metalloprotease 33 (ADAM33) can decrease the proliferation and increase the apoptosis of airway smooth muscle cells in a rat model of allergic asthma, suggesting ADAM33 represents a potential investigative focus target aiding allergic asthma. AbstractA defibrinogen and metalloproteinase 33 (ADAM33) was reported to play an important role in asthma. Furthermore, ADAM33 may play a possible role in airway remodeling due to its high expression in myo ‐/fibroblasts, epithelium, as well as the airway smooth muscle cells (ASMCs). Thus, the study is supposed to investigate the effect of the downregu...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Jing Zhou, Wei Bai, Qin Liu, Jian Cui, Wei Zhang Tags: RESEARCH ARTICLE Source Type: research

LncRNA CASC2 inhibits proliferation and migration of adenocarcinoma cells via miR ‐4735‐3p and mTOR
Cancer susceptibility candidate 2 and miR ‐4735‐3p pair regulate proliferation and migration of adenocarcinoma cells via the mammalian target of rapamycin (mTOR)‐associated signaling. This further confirmed the critical role of this signaling molecule in the development of lung adenocarcinoma and thus justified the efforts in developi ng new drugs targeting the mTOR‐associated signaling network. AbstractLung adenocarcinoma is a major form of non –small‐cell lung cancer that frequently strikes nonsmokers. The disease is often diagnosed at a late stage and the 5‐year survival rate is very low. Although prev...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Meng Luo, Demiao Kong, Dengke Pei, Xing Jin, Di Liu Tags: RESEARCH ARTICLE Source Type: research

Effect of autophagy on the resveratrol ‐induced apoptosis of ovarian cancer SKOV3 cells
This study aims to evaluate the relationship between apoptosis and autophagy induced by resveratrol (Res) in SKOV3 human ovarian cancer cell lines.MethodsThe experiment was divided into four groups: normal control group, Res group, Res combined with autophagy inhibitor 3 ‐methyladenine (Res+3‐MA) group, and Z‐VAD‐FMK group. SKOV3 cells were cultured and treated with Res and 3‐MA for 24 hours. The processing concentration of Res was screened out by the Cell Counting Kit‐8 (CCK8) assay. The cell survival rate was measured by the CCK8 assay. The expressio n of bule‐associated protein light chain 3 beta 2 ...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: HongYan Wang, Yan Peng, Jing Wang, AnXin Gu, Qi Li, DongWei Mao, LiYuan Guo Tags: RESEARCH ARTICLE Source Type: research

Activation of the mammalian target of rapamycin signaling pathway underlies a novel inhibitory role of ring finger protein 182 in ventricular remodeling after myocardial ischemia ‐reperfusion injury
In conclusion, our study demonstrates that RNF182 silencing can prevent ventricular remodeling in rats after MIRI by activating the mTOR signaling pathway. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Jing ‐Hua Wang, Zhi‐Feng Wei, Yan‐Li Gao, Cong‐Cong Liu, Jing‐Hui Sun Tags: RESEARCH ARTICLE Source Type: research

Sestrin2 regulates monocyte activation through AMPK ‐mTOR nexus under high‐glucose and dyslipidemic conditions
Sestrin2 expression levels were decreased upon high ‐glucose and oxidized LDL (OxLDL) treatments in monocytes with the alterations in adenosine monophosphate kinase (AMPK) and mechanistic target of rapamycin (mTOR) phosphorylation and activation. Further, we have observed that sestrin2 regulates monocyte activation, adhesion, and foam cell formatio n upon high‐glucose or OxLDL treatments through the AMPK–mTOR‐signaling pathway. Thus we conclude that sestrin2 could play a major role in the development of atherogenesis. AbstractThe vicious cycle between hyperinsulinemia and insulin resistance results in the progr...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Saravanakumar Sundararajan, Isaivani Jayachandran, Muthuswamy Balasubramanyam, Viswanathan Mohan, Balachandar Venkatesan, Nagaraj Manickam Tags: RESEARCH ARTICLE Source Type: research

Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand –mediated triple negative breast cancer cell death
Aryl hydrocarbon receptor ligand 5F 203 induces the expression of putative tumor suppressor cytoglobin (CYGB) and promotes anticancer activity and apoptosis in vivo and in vitro. CYGB promotes 5F 203 –mediated cell death, caspase‐3/‐7 activation, proapoptotic gene expression, lysosomal membrane permeabilization (LMP), and cathepsin B release in triple negative breast cancer (TNBC) cells. These findings suggest that AhR ligands such as 5F 203 upregulate CYGB to confer TNBC cell death. AbstractNearly 40 000 women die annually from breast cancer in the United States. Clinically available targeted breast cancer thera...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Leah K. Rowland, Petreena S. Campbell, Nicole Mavingire, Jonathan V. Wooten, Lancelot McLean, Dain Zylstra, Gabriell Thorne, Devin Daly, Kristopher Boyle, Sonya Whang, Juli Unternaehrer, Eileen J. Brantley Tags: RESEARCH ARTICLE Source Type: research