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4 ‐bp insertion/deletion (rs3783553) polymorphism within the 3'UTR of IL1A contributes to the risk of prostate cancer in a sample of Iranian Population
In conclusion, our findings proposed an association between IL1A 4‐bp ins/del polymorphism and PCa risk. Additional studies with enlarged sample size and diverse ethnicities are required to validate our finding. This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - October 12, 2017 Category: Biochemistry Authors: Mohammad Hashemi, Gholamreza Bahari, Shamim Sarhadi, Ebrahim Eskandari, Behzad Narouie, Mohsen Taheri, Saeid Ghavami Tags: Article Source Type: research

Evaluation of short ‐ and long‐term efficacy of chemoradiotherapy for advanced cervical cancer using HSP70 protein combined with multimodal MRI
This study aims to evaluate the efficacy of chemoradiotherapy for advanced cervical cancer using heat shock protein 70 (HSP70) combined with multimodal MRI. The protein expressions of HSP70 in biopsy specimens obtained from 101 patients with cervical cancer were detected by immunohistochemistry. Plain MRI scan, DWI, DCE‐MR and MRS were performed before and after a period of six months of chemoradiotherapy. All patients were assigned into the complete response (CR) and partial response (PR) groups. HSP70 protein expression, tumor diameter and tumor volume were lower in the CR group than in the PR group. The rate of tumor ...
Source: Journal of Cellular Biochemistry - October 11, 2017 Category: Biochemistry Authors: Yun ‐Xiang Qi, Kun Liu, Jun Yin, Lu Li Tags: Article Source Type: research

SNP Mutations Occurring in Thyroid Hormone Receptor Influenced Individual Susceptibility to Triiodothyronine: Molecular Dynamics and Site ‐Directed Mutagenesis Approaches
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - October 11, 2017 Category: Biochemistry Authors: Yaquan Liu, Kaili Qu, Ying Hai, Xin Li, Lei Zhao, Chunyan Zhao Tags: Article Source Type: research

MicroRNA ‐29a inhibits proliferation and motility of Schwannoma cells by targeting CDK6
Conclusion: Our data suggested that miR‐29a could play an important role in inhibiting proliferation and motility of cancerous Schwann cells, and may suppress tumor growth through upregulation of CDK6.This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - October 11, 2017 Category: Biochemistry Authors: Ji Ma, Tengfei Li, Huifeng Yuan, Xinwei Han, Shaofeng Shui, Dong Guo, Lei Yan Tags: Article Source Type: research

Phospholipid Secretions of Organ Cultured Ciliary Body
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - October 5, 2017 Category: Biochemistry Authors: Michael J. Margolis, Mitchell Martinez, Jeffrey Valencia, Richard K. Lee, Sanjoy K. Bhattacharya Tags: Article Source Type: research

MicroRNA ‐588 is upregulated in human prostate cancer with prognostic and functional implications
Conclusion: Aberrant upregulation of endogenous miR‐588 in PCa patients may be a prognostic biomarker, indicative of their poor clinical outcomes. Inhibiting endogenous miR‐588 may also serve as a therapeutic target for PCa treatment. This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - October 5, 2017 Category: Biochemistry Authors: Nan Zhao, Tao Lin, Changbo Zhao, Shikai Zhao, Shiming Zhou, Yuqiao Li Tags: Article Source Type: research

Interleukin ‐1 receptor‐associated kinase 1 correlates with metastasis and invasion in endometrial carcinoma
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - October 5, 2017 Category: Biochemistry Authors: Yilin Wang, Yanyan Wang, Xianzhi Duan, Yinuo Wang, Zhenyu Zhang Tags: Article Source Type: research

Identification of over expressed proteins in Oral Submucous Fibrosis by proteomic analysis
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - October 5, 2017 Category: Biochemistry Authors: Tapasi Das, Chandraday Prodhan, Santunu Patsa, Jay Gopal Ray, Keya Chaudhuri Tags: Article Source Type: research

MiR ‐132‐3p regulates ADAMTS‐5 expression and promotes chondrogenic differentiation of rat mesenchymal stem cells
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - October 5, 2017 Category: Biochemistry Authors: Xiaozhong Zhou, Dixin Luo, Hongtao Sun, Yong Qi, Wangyang Xu, Xunjie Jin, Chao Li, Zhousheng Lin, Guitao Li Tags: Article Source Type: research

Structural insights into impact of Y134F mutation and discovery of novel fungicidal compounds against CYP51 in Puccinia triticina
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - October 5, 2017 Category: Biochemistry Authors: Bharati Pandey, Pradeep Sharma Tags: Article Source Type: research

Role of pncA gene mutations W68R and W68G in Pyrazinamide resistance
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - October 5, 2017 Category: Biochemistry Authors: Mansi Aggarwal, Aditi Singh, Sonam Grover, Bharati Pandey, Anchala Kumari, Abhinav Grover Tags: Article Source Type: research

Low ‐intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - October 5, 2017 Category: Biochemistry Authors: Kenichi Matsumoto, Tsuyoshi Shimo, Naito Kurio, Tatsuo Okui, Soichiro Ibaragi, Yuki Kunisada, Kyoichi Obata, Masanori Masui, Pang Pai, Yuu Horikiri, Nobuyuki Yamanaka, Masaharu Takigawa, Akira Sasaki Tags: Article Source Type: research

Diet and cancer prevention: Dietary compounds, dietary MicroRNAs, and dietary exosomes
Abstract Cancer is one of main health public problems worldwide. Several factors are involved in beginning and development of cancer. Genetic and internal/external environmental factors can be as important agents that effect on emerging and development of several cancers. Diet and nutrition may be as one of important factors in prevention or treatment of various cancers. A large number studies indicated that suitable dietary patterns may help to cancer prevention or could inhibit development of tumor in cancer patients. Moreover, a large numbers studies indicated that a variety of dietary compounds such as curcumin, green ...
Source: Journal of Cellular Biochemistry - October 4, 2017 Category: Biochemistry Authors: Zarrin Banikazemi, Hemat Aghagolzadeh Haji, Mohsen Mohammadi, Gholamreza Taheripak, Elmira Iranifar, Mohsen Poursadeghiyan, Abdullah Moridikia, Bahman Rashidi, Mohsen Taghizadeh, Hamed Mirzaei Tags: PROSPECT Source Type: research

cAMP/PKA signaling pathway contributes to neuronal apoptosis via regulating IDE expression in a mixed model of type 2 diabetes and Alzheimer's disease
Abstract Type 2 diabetes (T2D) may play a relevant role in the development of Alzheimer's disease (AD), however, the underlying mechanism was not clear yet. We developed an animal model presenting both AD and T2D, morris water maze (MWM) test and recognition task were performed to trace the cognitive function. Fasting plasma glucose (FPG) and oral glucose tolerance test (OGTT) were determined to trace the metabolism evolution. TUNEL assay and apoptosis‐related protein levels were analyzed for the detection of neuronal apoptosis. Cyclic adenosine monophosphate (cAMP) agonist bucladesine or protein kinase (PKA) inhibitor H...
Source: Journal of Cellular Biochemistry - September 28, 2017 Category: Biochemistry Authors: Huajie Li, Song Yang, Jian Wu, Lei Ji, Linfeng Zhu, Liping Cao, Jinzhong Huang, Qingqing Jiang, Jiang Wei, Meng Liu, Keshi Mao, Ning Wei, Wei Xie, Zhilong Yang Tags: RESEARCH ARTICLE Source Type: research

SENP1/HIF ‐1α feedback loop modulates hypoxia‐induced cell proliferation, invasion, and EMT in human osteosarcoma cells
Hypoxia is an element intrinsic to most solid‐tumor microenvironments, including that of osteosarcoma (OS), and is associated with resistance to therapy, poor survival, and a malignant phenotype. The purpose of the present study was to investigate the role and underlying mechanism of SUMO‐specific protease 1 (SENP1)/hypoxia‐inducible factor‐1α (HIF‐1α) feedback loop in hypoxic microenvironment of OS. We observed that the expression of SENP1 was remarkably upregulated in OS cells. Additionally, there was a concomitant high expression of HIF‐1α and SENP1 in MG‐63 cells under a hypoxic microenv...
Source: Journal of Cellular Biochemistry - September 27, 2017 Category: Biochemistry Authors: Xiaowei Wang, Xiaoju Liang, Huan Liang, Bing Wang Tags: RESEARCH ARTICLE Source Type: research

A prognostic 11 genes expression model for ovarian cancer
Abstract The symptoms of ovarian cancer at early stages are usually absent which makes the diagnosis in its early stages exceedingly difficult. Previous research has proven that ovarian cancer is a genetic disease, which depends on the alteration of multi‐cancer related genes and anti‐cancer genes, multi‐stages and multi‐pathways, involving a variety of oncogene activation and anti‐oncogene inactivation. For a better understanding of the prognostic classification of ovarian cancer, gene expression profiles were used to analyze the prognostic factors of ovarian cancer, and the prognostic model was used to classify...
Source: Journal of Cellular Biochemistry - September 27, 2017 Category: Biochemistry Authors: Chuan ‐Di Men, Qiong‐Na Liu, Qing Ren Tags: RESEARCH ARTICLE Source Type: research

The Roles of Interleukin ‐1 and RhoA Signaling Pathway in Rat Epilepsy Model Treated with Low‐Frequency Electrical Stimulation
This study aims to explore the correlation between interleukin‐1 (IL‐1) and epilepsy in rats when treated with low‐frequency electrical stimulation via the RhoA/ROCK signaling pathway. Twenty‐four SD rats were elected for this study, among which six rats were assigned as the normal group. And 16 rat models with epilepsy were successfully established and assigned into the model group, the ES group and the ES + IL‐8 group, with each group comprising of six rats. The seizure frequency and duration was recorded. Electroencephalogram (EEG) power was detected at α1, α2, β, θ and δ. The mRNA...
Source: Journal of Cellular Biochemistry - September 23, 2017 Category: Biochemistry Authors: Ai ‐Hua Liu, Ya‐Ting Wu, Li‐Ping Li, Yu‐Ping Wang Tags: Article Source Type: research

Effects of Placebo ‐controlled Insulin‐sensitizing Drugs on Hormonal Parameters in Polycystic Ovary Syndrome Patients: A Network Meta‐analysis
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 23, 2017 Category: Biochemistry Authors: Yong ‐Hui Dai, Rong Huang, Peng‐Fei Zhao, Jian‐Hua Xu, Dong‐Dong Liu, Fu‐Dong Luo Tags: Article Source Type: research

Collagen, agarose, alginate and Matrigel hydrogels as cell substrates for culture of chondrocytes in vitro: A comparative study
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 23, 2017 Category: Biochemistry Authors: Zhikang Miao, Zhenhui Lu, Huayu Wu, Hui Liu, Muyan Li, Danqing Lei, Li Zheng, Jinmin Zhao Tags: Article Source Type: research

Inducing indel mutation in the SOX6 Gene by Zinc Finger Nuclease for gamma reactivation: An Approach towards Gene Therapy of Beta Thalassemia
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 23, 2017 Category: Biochemistry Authors: Mehran modares, Laleh shariati, Zahra Hejazi, Mansoureh Shahbazi, Mohammad Amin Tabatabaiefar, Hossein Khanahmad Tags: Article Source Type: research

SHH Gene Silencing Suppresses Epithelial ‐Mesenchymal Transition, Proliferation, Invasion and Migration of Cervical Cancer Cells by Repressing the Hedgehog Signaling Pathway
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 23, 2017 Category: Biochemistry Authors: Feng Zhang, Chen ‐Chen Ren, Ling Liu, Yan‐Nan Chen, Li Yang, Xiao‐An Zhang, Xiao‐Ming Wang, Feng‐Jing Yu Tags: Article Source Type: research

In vivo and in vitro effects of microRNA ‐124 on human gastric cancer by targeting JAG1 through the Notch signaling pathway
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 23, 2017 Category: Biochemistry Authors: Hai ‐Juan Xiao, Qing Ji, Lin Yang, Ren‐Ting Li, Cheng Zhang, Jun‐Ming Hou Tags: Article Source Type: research

Neural differentiation of bone marrow mesenchymal stem cells with human brain ‐derived neurotrophic factor gene‐modified in functionalized self‐assembling peptide hydrogel in vitro
Abstract Objective: To investigate the biocompatibility and differentiation of human brain‐derived neurotrophic factor (hBDNF) gene‐modified bone marrow mesenchymal stem cells (hBDNF‐rMSCs) in a functionalized self‐assembling peptide hydrogel.Methods: hBDNF were engineered in rMSCs using adenovirus vector and the enhanced green fluorescence protein (eGFP) was used as a reporter gene. MSC‐specific surface markers (CD90,CD29 and CD45)were used for identifying rMSCs. Fluorescence microscope was used to detect the transfection of rMSCs. hBDNF‐rMSCs and control cells (eGFP‐rMSCs) were seeded in a functional self...
Source: Journal of Cellular Biochemistry - September 20, 2017 Category: Biochemistry Authors: Hongbin Luo, Changsheng XU, Zhiwei Liu, Lin Yang, Yunda Hong, Guisheng Liu, Huifen Zhong, Xinyi Cai, Xuping Lin, Xiaokun Chen, Changsheng Wang, Nanwen Zhang, Weihong Xu Tags: Article Source Type: research

Stem cells and differentiated cells differ in their sensitivity to urine in vitro
Conclusion: Urothelial and smooth muscle cells seem to be more suitable for urinary bladder regeneration compared to mesenchymal stem cells, however these cells have limited application especially in the case of urinary bladder cancer. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 19, 2017 Category: Biochemistry Authors: Marta Pokrywczy ńska, Tomasz Kloskowski, Daria Balcerczyk, Monika Buhl, Arkadiusz Jundziłł, Maciej Nowacki, Kaja Męcińska‐Jundziłł, Tomasz Drewa Tags: Article Source Type: research

A CRISPR reimagining: new twists and turns of CRISPR beyond the genome ‐engineering revolution
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 19, 2017 Category: Biochemistry Authors: Robert J. Plummer, Yi Guo, Ying Peng Tags: Prospects Source Type: research

Procaine is a specific DNA methylation inhibitor with anti ‐tumor effect for human gastric cancer
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 19, 2017 Category: Biochemistry Authors: Yong ‐Chao Li, Yun Wang, Dan‐Dan Li, Ying Zhang, Tian‐Cheng Zhao, Chang‐Feng Li Tags: Article Source Type: research

Table of Contents, Editor's Choice, Features
(Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 18, 2017 Category: Biochemistry Tags: Issue Information Source Type: research

Cover Image, Volume 118, Number 11, November 2017
Cover: The cover image, by Maria Fernanda Suarez et al., is based on the Article, Phospholipidomic Studies in Human Cornea From Climatic Droplet Keratopathy, DOI: 10.1002/jcb.26045. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 18, 2017 Category: Biochemistry Authors: Maria Fernanda Suarez, Maria Carmen Piqueras, Leandro Correa, Evangelina Esposito, Maria Fernanda Barros, Sanjoy K. Bhattacharya, Julio A. Urrets ‐Zavalia, Horacio M. Serra Tags: Cover Source Type: research

SH3BP1 ‐induced Rac‐Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin
Abstract Cervical cancer still remains the fourth most common cancer, affecting women worldwide with large geographic variations in cervical cancer incidence and mortality rates. SH3‐domain binding protein‐1 (SH3BP1) specifically inactivating Rac1 and its target Wave2 is required for cell motility, thus regarded as an essential regulator of cancer cell metastasis. However, the exact effects and molecular mechanisms of SH3BP1 in cervical cancer progression are still unknown. The present study is aimed to investigate the mechanism of SH3BP1 in regulation of cervical cancer cell metastasis and chemoresistance. In the pres...
Source: Journal of Cellular Biochemistry - September 18, 2017 Category: Biochemistry Authors: Jingjing Wang, Yeqian Feng, Xishan Chen, Zheng Du, Shaijun Jiang, Shuyun Ma, Wen Zou Tags: RESEARCH ARTICLE Source Type: research

MicroRNA ‐410 Is Involved in Mitophagy after Cardiac Ischemia/Reperfusion Injury by Targeting High‐mobility group box 1 protein
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 15, 2017 Category: Biochemistry Authors: Fan Yang, Tong Li, Zhihuan Dong, Rui Mi Tags: Article Source Type: research

Cloning, Expression Pattern Analysis and Subcellular Localization of Capra hircus SCD1 gene with production of Transgenic Mice
This study aimed to clone the Stearoyl‐CoA desaturase 1 (SCD1) gene derived from Xuhuai goat (Capra hircus), and analyze the sub‐cellular localization in cells and tissues. The cDNA was cloned by reverse transcription polymerase chain reaction (RT‐PCR). pEGFP‐SCD1 vector was constructed to detect sub‐cellular localization and tissue distribution. pEGFP‐SCD1 was transfected into NIH‐3T3 cells using polyethylene imine (PEI) and observed under fluorescence inversion microscope system 48 h after transfection. The expression level of SCD1 was detected by RT‐PCR. Testicular injection was used to produce transgeni...
Source: Journal of Cellular Biochemistry - September 15, 2017 Category: Biochemistry Authors: Qisheng Zuo, Kai Jin, Jiuzhou Song, Yani Zhang, Bichun Li Tags: Article Source Type: research

Nrf2 Transfection Enhances the Efficacy of Human Amniotic Mesenchymal Stem Cells to Repair Lung Injury Induced by Lipopolysaccharide
This study aims to determine the protective effects of Nrf2‐transfected human amniotic mesenchymal stem cells (hAMSCs) against lipopolysaccharide (LPS)‐induced lung injury in mice. hAMSCs stably transfected with Nrf2 or green fluorescent protein control were transplanted into male C57BL/6 mice via the tail vein 4 h after intratracheal instillation of LPS. At 3, 7 and 14 days after cell transplantation, total lung injury score (the Smith score) was determined by hematoxylin and eosin staining. Lung fibrosis was assessed by Masson's trichrome staining. Alveolar epithelial apoptosis was determined by terminal deoxy...
Source: Journal of Cellular Biochemistry - September 14, 2017 Category: Biochemistry Authors: Shouqin Zhang, Wei Jiang, Lijie Ma, Yuhao Liu, Xiangyu Zhang, Sheng Wang Tags: Article Source Type: research

Curcumin alleviates IL ‐17A mediated p53‐PAI‐1 expression in bleomycin induced alveolar basal epithelial cells
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 13, 2017 Category: Biochemistry Authors: Mahesh Manjunath Gouda, Ashwini Prabhu, Yashodhar Prabhakar Bhandary Tags: Article Source Type: research

Regulation of Fibroblast Growth Factor 8 (FGF8) in Chicken Embryonic Stem Cells differentiation into Spermatogonial Stem Cells
This study further revealed the positive correlation between the expression level of FGF8 and MAPK/ERK signal. In the absence of FGF8, the expression of downstream genes such as FGFR2, GRB2, RAS, BRAF, RAF1 and MEK2 was not maintained, while overexpressing FGF8 enhances them. Thus, our study demonstrated that FGF8 can regulate germ cell fate by modulating the dynamic equilibrium between differentiation and self‐renewal, which provides a new idea for the study of germ cell regulatory network. This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 12, 2017 Category: Biochemistry Authors: Man Wang, Chen Zhang, Chuanli Huang, Shaoze Cheng, Nana He, Yilin Wang, Mahmoud F. Ahmed, Ruifeng Zhao, Jing Jin, Qisheng Zuo, Yani Zhang, Bichun Li Tags: Article Source Type: research

TPX2 ‐p53‐GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer
This study aims to explore the interplay between TPX2, p53, and GLIPR1 and its correlation with cell proliferation, invasion, and tumor growth in bladder cancer. Here, Western blot and qRT‐PCR analysis revealed that TPX2 at both mRNA and protein levels was up‐regulated in bladder carcinoma tissues compared to their paired adjacent normal tissues. Additionally, tissues expressing high TPX2 level exhibited high p53 level and low GLIPR1 level. The expressions of TPX2 and p53 in non‐muscle‐invasive bladder cancer cells (KK47 and RT4) were lower than those in muscle‐invasive bladder cancer cells (T24, 5637, and UM‐U...
Source: Journal of Cellular Biochemistry - September 11, 2017 Category: Biochemistry Authors: Liang Yan, Qi Li, Juan Yang, Baoping Qiao Tags: RESEARCH ARTICLE Source Type: research

SIRT1 deacetylates KLF4 to activate Claudin ‐5 transcription in ovarian cancer cells
In conclusion, our data suggest that SIRT1 activates CLDN5 transcription by deacetylating and potentiating KLF4. This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 9, 2017 Category: Biochemistry Authors: Xinjian Zhang, Junliang Chen, Lina Sun, Yong Xu Tags: Article Source Type: research

Exploring the interaction between Mycobacterium tuberculosisEnolase and human plasminogen using computational methods and experimental techniques
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 9, 2017 Category: Biochemistry Authors: Amit Rahi, Alisha Dhiman, Damini Singh, Andrew M. Lynn, Mohd. Rehan, Rakesh Bhatnagar Tags: Article Source Type: research

Leptin Induces Matrix Metalloproteinase 7 Expression To Promote Ovarian Cancer Cell Invasion By Activating ERK And JNK Pathways
Abstract Leptin, an adipokine secreted by adipose tissue, induces cell invasion and metastasis. MMP7 is a member of the matrix metalloproteinase family that plays an important role in cell invasion. Here we evaluate the possible role and underlying mechanism of MMP7 in the leptin‐ mediated cell invasion in ovarian cancer cell lines. All experiments were carried out in cultured SKOV3, OVCAR3 and CaoV‐3 ovarian cell lines. MMP7 expression was determined using the western blot following treatment to various concentrations of leptin for defined time intervals. The activation of ERK, JNK and P38 MAP kinases were determined ...
Source: Journal of Cellular Biochemistry - September 8, 2017 Category: Biochemistry Authors: Ahmad Ghasemi, Seyed Isaac Hashemy, Mahmoud Aghaei, Mojtaba Panjehpour Tags: Article Source Type: research

Intranasal insulin treatment restores cognitive deficits and insulin signaling impairment induced by repeated methamphetamine exposure
This study aimed to examine whether MA induces cognitive deficits concomitant with insulin signaling impairment and mitochondrial dysfunctions and also intranasal (IN) insulin treatment can reverse cognitive deficits caused by MA. Rats were repeatedly treated with increasing doses of MA (1‐10 mg/kg) twice a day for 10 days, and their cognitive functions were assessed using Y‐maze, novel object recognition and passive avoidance tasks. The expression of components involved in insulin signaling (IR/IRS2/PI3K/Akt/GSK3β) and mitochondrial biogenesis (PGC‐1α, NRF1 and TFAM) was measured in the hippocampus. Thera...
Source: Journal of Cellular Biochemistry - September 8, 2017 Category: Biochemistry Authors: Elmira Beirami, Shahrbanoo Oryan, Seyedeh Masoumeh Seyedhoseini Tamijani, Abolhassan Ahmadiani, Leila Dargahi Tags: Article Source Type: research

Effects of Glut1 gene silencing on proliferation, differentiation and apoptosis of colorectal cancer cells by targeting the TGF ‐β/PI3K‐AKT‐mTOR signaling pathway
This study aims to investigate the effects of glucose transport l (Glut1) gene on proliferation, differentiation and apoptosis of colorectal cancer (CRC) cells by regulating the TGF‐β/PI3K‐AKT‐mTOR signaling pathway. Immunohistochemistry was conducted to detect the positive Glut1 expression. Normal human CRC epithelial cells (CCD‐18Co) and CRC cell line HCT116 were grouped into the control, blank, negative control (NC), and shGlut1‐1 groups. RT‐qPCR and Western blotting were performed to detect the expressions of Glut1, TGF‐β1, PI3K, AKT, PTEN, mTOR, Bcl‐2 and Bax. Protein expression of phosphoryl...
Source: Journal of Cellular Biochemistry - September 8, 2017 Category: Biochemistry Authors: Xue ‐Liang Wu, Li‐Kun Wang, Dong‐Dong Yang, Ming Qu, Yong‐Jiang Yang, Fei Guo, Lei Han, Jun Xue Tags: Article Source Type: research

Transplantation of hypoxic preconditioned neural stem cells benefits functional recovery via enhancing neurotrophic secretion after spinal cord injury in rats
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 8, 2017 Category: Biochemistry Authors: Wei ‐li Fan, Peng Liu, Guan Wang, Jung‐ang Pu, Xin Xue, Jian‐hua Zhao Tags: Article Source Type: research

Stathmin/Op18 Depletion Induces Genomic Instability and Leads to Premature Senescence in Human Normal Fibroblasts
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 8, 2017 Category: Biochemistry Authors: Deepmala Shrestha, Namil Kim, Kiwon Song Tags: Article Source Type: research

Effects of Cyclin D1 Gene Silencing on cell Proliferation, cell Cycle and Apoptosis of Hepatocellular Carcinoma Cells
In conclusion, Cyclin D1 gene silencing suppresses cell proliferation and inhibits cell apoptosis, which may be a new target approach in the treatment and management for HCC.This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 8, 2017 Category: Biochemistry Authors: Jin Chen, Xue Li, Qi Cheng, Deng Ning, Jie Ma, Zhi ‐Ping Zhang, Xiao‐Ping Chen, Li Jiang Tags: Article Source Type: research

Crocin reduces Aspergillus fumigatus ‐induced airway inflammation and NF‐κB signal activation
Abstract Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammation and its exacerbation is often accompanied by Aspergillus fumigatus (A. fumigatus) infection. Increasing evidences demonstrated the potent antioxidant and ‐inflammatory effects of crocin. However, the role of crocin in A. fumigatus‐induced inflammation is still unknown. We aimed to evaluate the role of crocin in inflammation response induced by A. fumigatus in human bronchial epithelial cells and the possible mechanisms. BEAS‐2B and NHBE cells were pretreated with crocin for 24 h, and then A. fumigatus conidia were added for ...
Source: Journal of Cellular Biochemistry - September 7, 2017 Category: Biochemistry Authors: Junfeng Du, Yumin Chi, Zhan Song, Qingguo Di, Zhitao Mai, Jian Shi, Min Li Tags: RESEARCH ARTICLE Source Type: research

HNF1A/CASC2 regulates pancreatic cancer cell proliferation through PTEN/Akt signaling
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 2, 2017 Category: Biochemistry Authors: Yaqun Yu, Shuai Liang, Yingqiong Zhou, Shuqun Li, Yixiong Li, Weijia Liao Tags: Article Source Type: research

Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 2, 2017 Category: Biochemistry Authors: Yeyang Wang, Wenjun Li, Mingsen Wang, Chuangxin Lin, Guitao Li, Xiaozhong Zhou, Junnan Luo, Dadi Jin Tags: Article Source Type: research

Effects of long ‐term hypoxia in human chondrosarcoma cells
In conclusion, low oxygen condition causes changes in the cellular amounts of several proteins. This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 2, 2017 Category: Biochemistry Authors: J. Piltti, J. Bygdell, C. J. Qu, M. J. Lammi Tags: Article Source Type: research

Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes
In conclusion, this study suggested that kaempferol may be utilized as an appropriate alternative for ATRA in APL patients. This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - September 2, 2017 Category: Biochemistry Authors: Maliheh Moradzadeh, Alijan Tabarraei, Hamid Reza Sadeghnia, Ahmad Ghorbani, Ashraf Mohamadkhani, Saiedeh Erfanian, Amirhossein Sahebkar Tags: Article Source Type: research

Anti ‐apoptosis Endothelial Cell‐secreted MicroRNA‐195‐5P promotes Pulmonary Arterial Smooth Muscle cell proliferation and migration in Pulmonary Arterial Hypertension
Abstract In the pathological mechanism of pulmonary arterial hypertension, the role of 31 apoptosis‐resistant pulmonary microvascular endothelial cells (PVECs/ AR) has been 32 emphasized on the pulmonary vascular remodeling. In the present study, we investigated 33 whether PVECs/ AR can promote the proliferation and migration of pulmonary arterial 34 smooth muscle cells (PASMCs), and to study the role of miR‐195‐5p in the crosstalk between 35 these two types of cells. We confirmed that PVECs/ AR can promote the proliferation and 36 migration of PASMCs in a co‐culture system of AR/ PVECs and PASMCs. Additionally, 37...
Source: Journal of Cellular Biochemistry - September 1, 2017 Category: Biochemistry Authors: Zhen Zeng, Yinchuan li, xin zhang, jun yao, Ying xue, yinghua Zou, shu zhuoling, Zhihua Jiao Tags: Article Source Type: research

Coexpression Analysis Reveals Key Gene Modules and Pathway of Human Coronary Heart Disease
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - August 31, 2017 Category: Biochemistry Authors: Yu Tang, Zun ‐Ping Ke, Yi‐Gen Peng, Ping‐Tai Cai Tags: Article Source Type: research