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Condition: Hypertension

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Total 587 results found since Jan 2013.

Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: Involvement of NFAT5.
CONCLUSIONS: Hyperosmolarity induces the gene transcription of AQP5, AQP8, and VEGF, as well as the secretion of VEGF from RPE cells. The data suggest that high salt intake resulting in osmotic stress may aggravate neovascular retinal diseases and edema via the stimulation of VEGF production in RPE. The downregulation of AQP5 under hypoxic conditions may prevent the resolution of edema. PMID: 25878490 [PubMed - in process]
Source: Molecular Vision - April 19, 2015 Category: Molecular Biology Tags: Mol Vis Source Type: research

Angiotensin II Activates the RhoA Exchange Factor Arhgef1 in Humans Renin-Angiotensin System
In conclusion, our results strongly suggest that Arhgef1 mediates Ang II–induced RhoA activation in humans. Moreover, they show that measurement of RhoA guanine exchange factor activity in peripheral blood mononuclear cells might be a useful method to evaluate RhoA guanine exchange factor activity in humans.
Source: Hypertension - May 13, 2015 Category: Cardiology Authors: Carbone, M. L., Bregeon, J., Devos, N., Chadeuf, G., Blanchard, A., Azizi, M., Pacaud, P., Jeunemaitre, X., Loirand, G. Tags: ACE/Angiotension receptors, Other hypertension, Other Vascular biology Renin-Angiotensin System Source Type: research

Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension.
In conclusion, arrestin2 and 3 expression is elevated in resistance arteries during the emergence of the early hypertensive phenotype, which underlies an enhanced ability to desensitize vasoconstrictor signalling and vessel contraction. Such regulatory changes may act to compensate for increased vasoconstrictor-induced vessel contraction. PMID: 25972452 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - May 13, 2015 Category: Cytology Authors: Willets JM, Nash CA, Rainbow RD, Nelson CP, Challiss RJ Tags: Am J Physiol Cell Physiol Source Type: research

Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein.
We reported that brain (pro)renin receptor (PRR) expression levels are elevated in deoxycorticosterone acetate (DOCA)-salt-induced hypertension; however, the underlying mechanism remained unknown. To address whether angiotensin (Ang II) type 1 receptor (AT1R) signaling is involved in this regulation, we implanted a DOCA pellet and supplying 0.9% saline as the drinking solution to C57BL/6J mice; SHAM pellet-implanted mice provided regular drinking water served as controls. Concurrently, mice were intracerebroventricularly (ICV) infused with the AT1R blocker losartan, angiotensin converting-enzyme inhibitor captopril, or art...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - May 20, 2015 Category: Physiology Authors: Li W, Liu J, Hammond SL, Tjalkens RB, Saifudeen Z, Feng Y Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Specific hepatic delivery of procollagen α1(I) siRNA in lipid‐like nanoparticles resolves liver fibrosis
Conclusion: The data reported in the present study extensively show that LNP‐siCol1a1 specifically reduce total hepatic collagen content without detectable side effects, potentially qualifying as a therapy for fibrotic liver diseases. This article is protected by copyright. All rights reserved.
Source: Hepatology - June 10, 2015 Category: Internal Medicine Authors: Carolina Jiménez Calvente, Alfica Sehgal, Yury Popov, Yong Ook Kim, Victor Zevallos, Ugur Sahin, Mustafa Diken, Detlef Schuppan Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research

Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells.
In conclusion, increased VEGF-A produced by MSC can account for the increased vessel formation observed during treprostinil treatment. The clinical relevance of these data was confirmed by the high level of VEGF-A detected in plasma from patients with paediatric PH who had been treated with treprostinil. Moreover, our results suggest that VEGF-A level in patients could be a surrogate biomarker of treprostinil efficacy. PMID: 26062754 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 11, 2015 Category: Hematology Authors: Smadja DM, Levy M, Huang L, Rossi E, Blandinieres A, Israël-Biet D, Gaussem P, Bischoff J Tags: Thromb Haemost Source Type: research

Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs
Conclusions BMP4 acts downstream of HIF-1 and mediates hypoxia-induced up-regulation of TRPC, leading to increased basal [Ca2+]i in PASMCs, promoting CHPH pathogenesis.
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Wang, J., Fu, X., Yang, K., Jiang, Q., Chen, Y., Jia, J., Duan, X., Wang, E. W., He, J., Ran, P., Zhong, N., Semenza, G. L., Lu, W. Tags: Vascular biology Source Type: research

Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus
This study provides strong evidence in neonatal endothelial progenitor cells that GDM exposure in utero leads to altered gene expression and DNA methylation, suggesting the possibility of altered epigenetic regulation.
Source: Diabetes - June 23, 2015 Category: Endocrinology Authors: Blue, E. K.; Sheehan, B. M.; Nuss, Z. V.; Boyle, F. A.; Hocutt, C. M.; Gohn, C. R.; Varberg, K. M.; McClintick, J. N.; Haneline, L. S. Tags: Genetics/Genomes/Proteomics/Metabolomics Source Type: research

Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein
We reported that brain (pro)renin receptor (PRR) expression levels are elevated in DOCA-salt-induced hypertension; however, the underlying mechanism remained unknown. To address whether ANG II type 1 receptor (AT1R) signaling is involved in this regulation, we implanted a DOCA pellet and supplied 0.9% saline as the drinking solution to C57BL/6J mice. Sham pellet-implanted mice that were provided regular drinking water served as controls. Concurrently, mice were intracerebroventricularly infused with the AT1R blocker losartan, angiotensin-converting-enzyme inhibitor captopril, or artificial cerebrospinal fluid for 3 wk. Int...
Source: AJP: Regulatory, Integrative and Comparative Physiology - July 15, 2015 Category: Physiology Authors: Li, W., Liu, J., Hammond, S. L., Tjalkens, R. B., Saifudeen, Z., Feng, Y. Tags: Cardiovascular and Renal Integration Source Type: research

Defects in Cullin3 Decrease RhoA Ubiquitination Protein Synthesis and Degradation
Cullin-Ring ubiquitin ligases regulate protein turnover by promoting the ubiquitination of substrate proteins, targeting them for proteasomal degradation. It has been shown previously that mutations in Cullin3 (Cul3) causing deletion of 57 amino acids encoded by exon 9 (Cul3Δ9) cause hypertension. Moreover, RhoA activity contributes to vascular constriction and hypertension. We show that ubiquitination and degradation of RhoA is dependent on Cul3 in HEK293T cells in which Cul3 expression is ablated by either siRNA or by CRISPR-Cas9 genome editing. The latter was used to generate a Cul3-null cell line (HEK293TCul3KO). When...
Source: Journal of Biological Chemistry - July 31, 2015 Category: Chemistry Authors: Ibeawuchi, S.-R. C., Agbor, L. N., Quelle, F. W., Sigmund, C. D. Tags: Molecular Bases of Disease Source Type: research

Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension
In conclusion, arrestin2 and 3 expression is elevated in resistance arteries during the emergence of the early hypertensive phenotype, which underlies an enhanced ability to desensitize vasoconstrictor signaling and vessel contraction. Such regulatory changes may act to compensate for increased vasoconstrictor-induced vessel contraction.
Source: AJP: Cell Physiology - August 1, 2015 Category: Cytology Authors: Willets, J. M., Nash, C. A., Rainbow, R. D., Nelson, C. P., Challiss, R. A. J. Tags: ARTICLES Source Type: research

Bromodomain Containing Protein-4: The Epigenetic Origin of Pulmonary Arterial Hypertension.
CONCLUSIONS: BRD4 plays a key role in the pathological phenotype in PAH, which could offer new therapeutic perspectives for PAH patients. PMID: 26224795 [PubMed - as supplied by publisher]
Source: Circulation Research - July 29, 2015 Category: Cardiology Authors: Meloche J, Potus F, Vaillancourt M, Bourgeois A, Johnson IH, Deschamps L, Chabot S, Ruffenach GN, Henry S, Breuils-Bonnet S, Tremblay È, Nadeau V, Lambert CM, Paradis R, Provencher S, Bonnet S Tags: Circ Res Source Type: research

Rho‐kinase inhibitor fasudil reduces allergic airway inflammation and mucus hypersecretion by regulating STAT6 and NFκB
ConclusionThese findings indicate that the RhoA/Rho kinase inhibitor, fasudil, plays a negative regulatory role in allergen‐induced mucus secretion and MUC5AC expression by regulating STAT6 and NFκB.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - August 1, 2015 Category: Allergy & Immunology Authors: Xie Tao, Luo Guangyan, Zhang Yun, Wang Xing, Wang Xiaoyun, Wu Min, Li Guoping Tags: Original Article‐Basic Mechanisms in Allergic Disease Source Type: research

Micellar carriers for the delivery of multiple therapeutic agents
Publication date: 1 November 2015 Source:Colloids and Surfaces B: Biointerfaces, Volume 135 Author(s): Rajesh Thipparaboina, Rahul B. Chavan, Dinesh Kumar, Srivani Modugula, Nalini R. Shastri Multi-drug therapy is described as a simultaneous or sequential administration of two or more drugs with similar or different mechanisms of action and is recognized as a more efficient solution to combat successfully, various ailments. Polymeric micelles (PMs) are self-assemblies of block copolymers providing numerous opportunities for drug delivery. To date various micellar formulations were studied for delivery of drugs, nutr...
Source: Colloids and Surfaces B: Biointerfaces - August 9, 2015 Category: Biochemistry Source Type: research

Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway
Publication date: Available online 12 August 2015 Source:FEBS Open Bio Author(s): Yang Song, Yonghong Zhang, Haoxiang Jiang, Yanting Zhu, Lu Liu, Wei Feng, Lan Yang, Yibin Wang, Manxiang Li Activation of the Notch3 cascade is involved in the development of pulmonary arterial hypertension by stimulating the proliferation of vascular smooth muscle cells. However, the detailed molecular mechanisms underlying this effect are still unclear. The present study aims to address this issue. We demonstrated that over-expression of intracellular domain of the Notch3 receptor (NICD3) by adenovirus transfection dramatically i...
Source: FEBS Open Bio - August 13, 2015 Category: Molecular Biology Source Type: research