Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension

In conclusion, arrestin2 and 3 expression is elevated in resistance arteries during the emergence of the early hypertensive phenotype, which underlies an enhanced ability to desensitize vasoconstrictor signaling and vessel contraction. Such regulatory changes may act to compensate for increased vasoconstrictor-induced vessel contraction.

Source: AJP: Cell Physiology - August 1, 2015 Category: Cytology Authors: Willets, J. M., Nash, C. A., Rainbow, R. D., Nelson, C. P., Challiss, R. A. J. Tags: ARTICLES Source Type: research