Sleep deficiency and mortality: is the solution in the gut?
Sleep deficiencyOxidative stressAntioxidantIntestinesCardiovascular disease (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 18, 2021 Category: Cardiology Source Type: research

To serve and protect: a new heart patrolling and recycling role for macrophages
 MacrophagesCardiomyocyteExtracellular vesiclesExophereAutophagy (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 18, 2021 Category: Cardiology Source Type: research

Atrial fibrillation after cardiac surgery: to screen or not to screen?
Atrial fibrillation (AF) is diagnosed in 20 –40% of patients in the first week after cardiac surgery and is largely self-limiting, with the majority of patients being discharged from hospital in sinus rhythm (SR). However, that is not the end of it. The rate of subsequent AF development is higher in cardiac surgery patients who experience A F during hospital admission compared to those who do not1; patients with postoperative AF also have a longer hospital stay, a higher long-term risk of stroke (both ischaemic and haemorrhagic) and worse overall prognosis.1 –5 (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 18, 2021 Category: Cardiology Source Type: research

Connecting the dots? Rate control, heart failure, and atrial fibrillation
This editorial refers to ‘Role of atrial arrhythmia and ventricular response in atrial fibrillation induced atrial remodelling’ by J-B Guichardet al., pp. 462 –471. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 17, 2021 Category: Cardiology Source Type: research

Highlights of American Heart Association Scientific Sessions 2020: a virtual experience
American Heart AssociationClinical trialsCardiovascular medicineTranslational researchCOVID-19 (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 10, 2021 Category: Cardiology Source Type: research

Co-ordinated mitochondrial degradation by autophagy and heterophagy in cardiac homeostasis
 AutophagyMacrophageMitochondriaMetabolismHeart (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 4, 2021 Category: Cardiology Source Type: research

Colchicine in coronary disease: another renaissance of an ancient drug
Coronary diseaseInflammationColchicineClinical trials (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 29, 2020 Category: Cardiology Source Type: research

Scientists on the Spot: RNA modifications in atherosclerosis
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2020 Category: Cardiology Source Type: research

They eat, what we eat, they digest, what we ingest: the microbiome and the vulnerable plaque
This editorial refers to ‘Plasma levels of trimethylamine-N-oxide can be increased with ‘healthy’ and ‘unhealthy’ diets and do not correlate with the extent of atherosclerosis but with plaque instability’ by Y.C, Koayet al., pp. 435 –449. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 3, 2020 Category: Cardiology Source Type: research

Scientists on the Spot: Inflammation in atherosclerosis
 InflammationImmunomodulatoryAtherosclerosisESCCouncil on Basic Cardiovascular Science (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 1, 2020 Category: Cardiology Source Type: research

Life course psychological distress and cardiovascular disease risk factors in middle age: birth cohort study
Recent findings suggest that psychological distress in childhood —a combination of symptoms of anxiety and depression—particularly when persistent across the life course is related to an elevated rate of cardiovascular disease mortality in older age.1 Several mechanisms have been implicated with one possibility being that people who experience distress in early life, and particularly its recurrence across the life course, may become more susceptible to vascular disease via differences in physiological development. There is, however, a paucity of studies holding data on early distress and biological risk factors...
Source: Cardiovascular Research - November 27, 2020 Category: Cardiology Source Type: research

The endothelium as Achilles ’ heel in COVID-19 patients
COVID-19HeartEndothelial cellsEndotheliitis (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 27, 2020 Category: Cardiology Source Type: research

A vitaminic boost to rock the aortic wall
This editorial refers to ‘Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide ’ by T. Horimatsuet al., pp. 2226 –2238. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 27, 2020 Category: Cardiology Source Type: research

Pathophysiological consequences of the EAST-AFNET4 trial: AF is not an innocent bystander
Atrial fibrillationPathophysiologyStrokeOutcomeEAST (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 27, 2020 Category: Cardiology Source Type: research

Cardiovascular  Research and social media: connecting with researchers, advancing science
 Social mediaCardiovascularDigitalResearchCardiology (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 27, 2020 Category: Cardiology Source Type: research

Leaders in Cardiovascular Research: Stefanie Dimmeler
ESCBasic scienceNon-coding RNARegenerationNitric oxide (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 27, 2020 Category: Cardiology Source Type: research

COVID-19, hypertension, and RAAS blockers: the BRACE-CORONA trial
CoronaSARS-CoV-2RAASACEAngiotensin (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 27, 2020 Category: Cardiology Source Type: research

The ESC Global Affairs Committee (2018 –20): tackling cardiovascular disease worldwide
ESCGlobal affairsCardiovascularDigitalSociety (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 27, 2020 Category: Cardiology Source Type: research

The ESC Publications Committee: scope, successes, and challenges 2009 –20
ESC Journal FamilyESC Journal Family Ethics CommitteeImpact and influenceManuscript transfer Open access (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 21, 2020 Category: Cardiology Source Type: research

Correction to: Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC working groups of myocardial function and cellular biology of the heart
[cardiovasc res 2020; 116(11):1805-1819. doi:10.1093/cvr/cvaa195] (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2020 Category: Cardiology Source Type: research

Numbers and phenotype of non-classical CD14dimCD16+ monocytes are predictors of adverse clinical outcome in patients with coronary artery disease and severe SARS-CoV-2 infection
AbstractAims  To elucidate the prognostic role of monocytes in the immune response of patients with coronary artery disease (CAD) at risk for life-threatening heart and lung injury as major complications of SARS-CoV-2 infection.Methods and results  From February to April 2020, we prospectively studied a cohort of 96 participants comprising 47 consecutive patients with CAD and acute SARS-CoV-2 infection (CAD  + SARS-CoV-2), 19 CAD patients without infections, and 30 healthy controls. Clinical assessment included blood sampling, echocardiography, and electrocardiography within 12 h of admission...
Source: Cardiovascular Research - November 3, 2020 Category: Cardiology Source Type: research

Scientists on the Spot: Phosphodiesterases and heart failure
Cyclic nucleotidesPhosphodiesterasesHeart pathophysiologyCalcium channels (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 1, 2020 Category: Cardiology Source Type: research

Using machine learning to ace cardiovascular risk tests
This editorial refers to ‘Machine learning to predict the long-term risk of myocardial infarction and cardiac death based on clinical risk, coronary calcium, and epicardial adipose tissue: a prospective study’ by F. Commandeuret al., pp. 2216 –2225. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 30, 2020 Category: Cardiology Source Type: research

Connexin hemichannels in atrial fibrillation: orphaned and irrelevant?
This editorial refers to ‘RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes ’ by A. Lissoniet al., pp. 123 –136. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 28, 2020 Category: Cardiology Source Type: research

Regional and global contributions of air pollution to risk of death from COVID-19
ConclusionOur results suggest that air pollution is an important cofactor increasing the risk of mortality from COVID-19. This provides extra motivation for combining ambitious policies to reduce air pollution with measures to control the transmission of COVID-19. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 26, 2020 Category: Cardiology Source Type: research

Scientists on the Spot: from the Scientists of Tomorrow to the scientist of today
ESCCardioprotectionIschaemic heart diseaseScientists of tomorrowAward (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 23, 2020 Category: Cardiology Source Type: research

Scientists on the Spot: Rejuvenating the heart with RNA
 Cardiac regenerationMicroRNANon-coding RNAESCAgeing (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 23, 2020 Category: Cardiology Source Type: research

ESC Congress 2020, the digital experience: a report from the ESC Scientists of Tomorrow
ESC conferenceTranslational researchClinical guidelinesClinical studiesCOVID-19 (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 23, 2020 Category: Cardiology Source Type: research

Cardiovascular Research at the heart of the digital experience: ESC Congress 2020
AtherosclerosisCardio-immunologyCardiovascularPublishingHypertension (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 23, 2020 Category: Cardiology Source Type: research

Home treatment of pulmonary embolism: are all the questions answered now after the HOME-PE trial?
PulmonarysPESIHestiathrombosis (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 23, 2020 Category: Cardiology Source Type: research

Ageing is associated with increased variability of cellular reprogramming and wound healing
 Induced pluripotent stem cellsAgeingFibroblastsWound healingRegenerative medicine (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2020 Category: Cardiology Source Type: research

The end of the beginning for drug therapy in obstructive hypertrophic cardiomyopathy with EXPLORER-HCM
Hypertrophic cardiomyopathyMavacamtenCardiac myosin ATPaseOutflow tract obstruction (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2020 Category: Cardiology Source Type: research

Double trouble: combined cardiovascular effects of particulate matter exposure and coronavirus disease 2019
AbstractThe coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly grown into a pandemic. According to initial reports, the lungs were thought to be the primary target, but recent case studies have shown its reach can extend to other organs including the heart and blood vessels. The severity of cardiac complications of COVID-19 depends on multiple underlying factors, with air pollutant exposure being one of them, as reported by several recent studies. Airborne particulate matter (PM) attracts heightened attention due to its implication in various diseases, esp...
Source: Cardiovascular Research - October 21, 2020 Category: Cardiology Source Type: research

Correction to: Kramann N. et al. ‘B-RAF and its novel negative regulator reticulocalbin 1 (RCN1) modulates cardiomyocyte hypertrophy’
Correction to: Kramann N.et al.‘B-RAF and its novel negative regulator reticulocalbin 1 (RCN1) modulates cardiomyocyte hypertrophy’.Cardiovasc Res 2014;102(1):88 –96. doi:10.1093/cvr/cvu024 (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 20, 2020 Category: Cardiology Source Type: research

Chronic low-dose rapamycin treatment fine tunes cardioprotective signalling in ischaemia-reperfused diabetic hearts
This editorial refers to ‘STAT3-miR-17/20 signaling axis plays a critical role in attenuating myocardial infarction following rapamycin treatment in Diabetic mice’, by A.Samidurai et al. pp. 2103 –2115. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 20, 2020 Category: Cardiology Source Type: research

A tribute to James Thornton Willerson, M.D. November 16, 1939 –September 16, 2020
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 18, 2020 Category: Cardiology Source Type: research

Hypertension and SARS-CoV-2 infection: is inflammation the missing link?
Cardiovascular riskHypertensionSARS-CoV2 infectionCytokine storm; InflammationToll-like 4 receptor (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 17, 2020 Category: Cardiology Source Type: research

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities
We present preclinical evidence identifying the influence of biological sex on the expression and regulation of angiotensin-converting enzyme 2 (ACE2), which is the main receptor used by SARS-CoV-2 to enter cells. However, we note that there is a lack of reports showing that sexual dimorphism of ACE2 expression exists and is of functional relevance in humans. In contrast, there is strong evidence, especially in the context of viral infections, that sexual dimorphism plays a central role in the genetic and hormonal regulation of immune responses, both of the innate and the adaptive immune system. We review evidence supporti...
Source: Cardiovascular Research - October 16, 2020 Category: Cardiology Source Type: research

Defining circulating mononuclear cells in heart failure through single-cell RNA sequencing: new insights for an old disease
html5-player.libsyn.com/embed/episode/id/16291715/height/360/theme/standard/thumbnail/yes/direction/backward/stats-code/ESCJournal/ (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2020 Category: Cardiology Source Type: research

The impact of low-dose anticoagulation therapy on peripheral artery disease: insights from the VOYAGER trial
Peripheral artery disease (PAD)VOYAGER trialLow-dose anticoagulationAtherothrombosis (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 26, 2020 Category: Cardiology Source Type: research

Picking up the pace: another record high impact factor for Cardiovascular Research
CardiovascularResearchImpact factorAltmetricCitation (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 26, 2020 Category: Cardiology Source Type: research

Vericiguat in worsening heart failure: agonising over, or celebrating, agonism in the VICTORIA trial
VericiguatHeart failureNitric oxidesGC (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 26, 2020 Category: Cardiology Source Type: research

Mobile cardiology during the COVID-19 outbreak
Commentary on ‘Rapid implementation of mobile technology for real-time epidemiology of COVID-19’, by D. Drewet al., Science 2020; doi: 10.1126/science.abc0473. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 25, 2020 Category: Cardiology Source Type: research

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes
ConclusionThis study demonstrates that SARS-CoV-2 infects cardiomyocytesin vitro in an angiotensin-converting enzyme 2- and cathepsin-dependent manner. SARS-CoV-2 infection of cardiomyocytes is inhibited by the antiviral drug remdesivir. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 23, 2020 Category: Cardiology Source Type: research

ESC Advocacy (2018 –2020): contributing to the ESC mission of reducing the burden of cardiovascular disease
ESCAdvocacyCardiovascularBurdenCommittee (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 8, 2020 Category: Cardiology Source Type: research

Leaders in Cardiovascular Research: Filippo Crea
Watch the interview here: https://youtu.be/myCo6U4o7Ts (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 31, 2020 Category: Cardiology Source Type: research

Corrigendum to: Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates cells via mesenchymal stem cell intermediates
[Cardiovasc Res 2012;96:391 –400https://doi.org/10.1093/cvr/cvs253] (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 9, 2020 Category: Cardiology Source Type: research

Insights into cardiovascular research in G öttingen and Heidelberg: a report by the ESC Scientists of Tomorrow
Cardiovascular research developmentsLatest insightsHeart failureAtrial fibrillation (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 5, 2020 Category: Cardiology Source Type: research

A neurohumoral activation of renin-angiotensin-aldosterone system in endothelial dysfunction modulating immunity in heart failure
This editorial refers to ‘Nox2+ myeloid cells drive vascular inflammation and endothelial dysfunction in heart failure after myocardial infarction via angiotensin II receptor type 1 ’ by M. Molitoret al., pp. 162 –177. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 4, 2020 Category: Cardiology Source Type: research

Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science
AbstractThe COVID-19 pandemic is an unprecedented healthcare emergency causing mortality and illness across the world. Although primarily affecting the lungs, the SARS-CoV-2 virus also affects the cardiovascular system. In addition to cardiac effects, e.g. myocarditis, arrhythmias, and myocardial damage, the vasculature is affected in COVID-19, both directly by the SARS-CoV-2 virus, and indirectly as a result of a systemic inflammatory cytokine storm. This includes the role of the vascular endothelium in the recruitment of inflammatory leucocytes where they contribute to tissue damage and cytokine release, which are key dr...
Source: Cardiovascular Research - August 4, 2020 Category: Cardiology Source Type: research