Coronary artery disease patients without standard modifiable risk factors (SMuRFs)- a forgotten group calling out for new discoveries
Coronary artery diseaseAtherosclerosisRisk factorsBioinformaticsBiomarkers (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 22, 2021 Category: Cardiology Source Type: research

Scientists on the Spot: Re-awakening the heart ’s regenerative capacity
Cardiac repairRegenerationMicroRNAEmbryonicEndogenous (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 22, 2021 Category: Cardiology Source Type: research

Scientist on the Spot: Exploring the cause and cure for pulmonary arterial hypertension
Pulmonary arterial hypertensionMitochondriaRedoxEpigeneticsPrecision medicine (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 21, 2021 Category: Cardiology Source Type: research

Coping with sterile inflammation: between risk and necessity
MyocardiumImmune systemInflammationMyocardial infarctionDisease tolerance (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 18, 2021 Category: Cardiology Source Type: research

From polygenic risk scores to integrative epigenomics: the dawn of a new era for cardiovascular precision medicine
Integrative epigenomicsGenome-wide association study (GWAS)Complex traitsCoronary artery disease (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 29, 2021 Category: Cardiology Source Type: research

VE-PTP inhibition: a novel therapeutic target for hypertension in diabetic patients
This editorial refers to ‘VE-PTP inhibition elicits eNOS phosphorylation to blunt endothelial dysfunction and hypertension in diabetes’ by M. Siragusaet al., pp. 1546 –1556. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 26, 2021 Category: Cardiology Source Type: research

Avalanching nanoparticles bring new light to cardiovascular imaging
Avalanching nanoparticlesNanoscienceUpconversion nanoparticlesCardiovascular imagingArtificial intelligence (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 20, 2021 Category: Cardiology Source Type: research

A titan of Cardiovascular Research: Professor Peter Sleight (1929 –2020)
Cardiovascular researchCardiologyMemorialAspirinThrombolysis (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 20, 2021 Category: Cardiology Source Type: research

The neurology of hypertension: merging academic specialties to connect heart and brain pathophysiology
HypertensionBrainAutonomic nervous systemImmunityDementia (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 5, 2021 Category: Cardiology Source Type: research

Current trends in the use of machine learning for diagnostics and/or risk stratification in cardiovascular disease
Artificial intelligenceMachine learningImagingRiskDeep-learning (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 18, 2021 Category: Cardiology Source Type: research

Single-cell transcriptomics as a building block for determining mechanistic insight of abdominal aortic aneurysm formation
This editorial refers to ‘Single-cell RNA sequencing reveals the cellular heterogeneity of aneurysmal infrarenal abdominal aorta’ by G. Zhaoet al., pp.1402 –1416. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 16, 2021 Category: Cardiology Source Type: research

Jumping on base editing to repair the diseased cardiovascular system in vivo
Genome editingBase editingHutchinson –Gilford progeria syndromeGene therapyVascular smooth muscle (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 16, 2021 Category: Cardiology Source Type: research

Arterial lymphangiogenesis ReSPONDINg 2 a new cue: the R-spondin2/LRG4 axis limits VEGFR3-mediated lymphangiogenesis and reverse cholesterol transport
This editorial refers to ‘Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis’ by B. Singlaet al., pp.1489 –1509. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 13, 2021 Category: Cardiology Source Type: research

Flow, pressure, anatomy: an eternal golden braid
This editorial refers to ‘A novel method for measuring absolute coronary blood flow& microvascular resistance in patients with ischaemic heart disease ’ by P.D. Morriset al., pp.1567 –1577. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 13, 2021 Category: Cardiology Source Type: research

Human cardiosphere-derived stromal cells exposed to SARS-CoV-2 evolve into hyper-inflammatory/pro-fibrotic phenotype and produce infective viral particles depending on the levels of ACE2 receptor expression
Conclusions  Our findings indicate that cardiac stromal cells are susceptible to SARS-CoV-2 infection and produce variable viral yields depending on the extent of cellular ACE2 receptor expression. Interestingly, these cells also evolved towards hyper-inflammatory/pro-fibrotic phenotypes independently of ACE2 levels. Thus, SARS-CoV-2 infection of myocardial stromal cells could be involved in cardiac injury and explain the high number of complications observed in severe cases of COVID-19. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 10, 2021 Category: Cardiology Source Type: research

Bad company: monocytes in HIV and atherosclerosis
This editorial refers to ‘Classical monocyte transcriptomes reveal significant anti-inflammatory statin effect in women with chronic HIV’ by E. Ehingeret al., pp.1166 –1177. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 6, 2021 Category: Cardiology Source Type: research

Low-intensity pulsed ultrasound (LIPUS) in heart failure with preserved ejection fraction (HFpEF): lupus in fabula?
This editorial refers to ‘Low-intensity pulsed ultrasound ameliorates cardiac diastolic dysfunction in mice: a possible novel therapy for heart failure with preserved left ventricular ejection fraction’ by Y. Monmaet al., pp.1325 –1338. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 5, 2021 Category: Cardiology Source Type: research

Metformin again? Atheroprotection mediated by macrophage AMPK and ATF1
This editorial refers to ‘Metformin directly suppresses atherosclerosis in normoglycemic mice via haematopoietic Adenosine Monophosphate-Activated Protein Kinase (AMPK)’ by A. Seneviratneet al., pp.1295 –1308. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 3, 2021 Category: Cardiology Source Type: research

Apolipoprotein B is an insufficient explanation for the risk of coronary disease associated with lipoprotein(a)
Lipoprotein(a) is a plasma lipoprotein composed of a low-density lipoprotein (LDL) particle linked to apolipoprotein(a). The risk of coronary artery disease (CAD) associated with lipoprotein(a) has been associated with both molar concentration and apolipoprotein(a) isoform size, which are inversely correlated properties and highly heritable.1 Similar to LDL, lipoprotein(a) harbours apolipoprotein B and is associated with increased risk of CAD. Apolipoprotein B is believed to be a key unifying feature of atherogenic lipoproteins.2 However, it is unclear to what extent non-apolipoprotein B-mediated mechanisms of lipoprotein(...
Source: Cardiovascular Research - February 24, 2021 Category: Cardiology Source Type: research

Scientists on the Spot: Repairing and restoring the heart
Cardiac repairRegenerationDevelopmentalEmbryonicEndogenous (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 24, 2021 Category: Cardiology Source Type: research

New trials in the scene of cardiovascular disease: innovation, controversy, and reassurance
EvinacumabLipid-loweringFish oilsOmega-3Fatty acids (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 22, 2021 Category: Cardiology Source Type: research

Corrigendum to: CD1d-dependent natural killer T cells attenuate angiotensin II-induced cardiac remodelling via IL-10 signalling in mice. Cardiovascular Research (2019) 115, 83 –93
This is a correction to: Cardiovascular Research, Volume 115, Issue 1, 1 January 2019, Pages 83 –93, doi:10.1093/cvr/cvy164. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 19, 2021 Category: Cardiology Source Type: research

Long, longer, long QT syndrome: what makes the difference?
 Listen to the podcast associated with this article, which can also be found at ESC CardioTalk https://www.escardio.org/The-ESC/Whatwe-do/news/ESC-Cardio-Talk (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 19, 2021 Category: Cardiology Source Type: research

Leaders in Cardiovascular Research: Joseph Hill
 CirculationHeart failureGlobal healthBasic scienceCardiology (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 19, 2021 Category: Cardiology Source Type: research

Heart failure or heart success?
 HFrEFCardiac myosinFerric carboxymaltoseSotagliflozin (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 13, 2021 Category: Cardiology Source Type: research

COVID-19, the wake-up call for implementing sex and gender in cardiovascular disease
Cardiovascular diseaseEqualityGenderWomenSex differences (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 7, 2021 Category: Cardiology Source Type: research

Corrigendum to: Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells
[Cardiovasc Res. 2012;93(1):162-9; doi:10.1093/cvr/cvr282] (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 30, 2021 Category: Cardiology Source Type: research

Ultrasound-guided catheter implantation improves conscious radiotelemetric blood pressure measurement in mice
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 23, 2021 Category: Cardiology Source Type: research

Endothelin in diabetes-associated atherosclerosis: opportunity ‘NOX’
This editorial refers to ‘Endothelium-restricted endothelin-1overexpression in type 1 diabetes worsens atherosclerosis and immune cell infiltration via NOX1’ by S. Ouerdet al., pp.1144 –1153. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 20, 2021 Category: Cardiology Source Type: research

Haemodynamics of atherosclerosis: a matter of higher hydrostatic pressure or lower shear stress?
AtherosclerosisHaemodynamicsHydrostatic pressureShear stressBlood flow (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 19, 2021 Category: Cardiology Source Type: research

Sleep deficiency and mortality: is the solution in the gut?
Sleep deficiencyOxidative stressAntioxidantIntestinesCardiovascular disease (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 18, 2021 Category: Cardiology Source Type: research

To serve and protect: a new heart patrolling and recycling role for macrophages
 MacrophagesCardiomyocyteExtracellular vesiclesExophereAutophagy (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 18, 2021 Category: Cardiology Source Type: research

Atrial fibrillation after cardiac surgery: to screen or not to screen?
Atrial fibrillation (AF) is diagnosed in 20 –40% of patients in the first week after cardiac surgery and is largely self-limiting, with the majority of patients being discharged from hospital in sinus rhythm (SR). However, that is not the end of it. The rate of subsequent AF development is higher in cardiac surgery patients who experience A F during hospital admission compared to those who do not1; patients with postoperative AF also have a longer hospital stay, a higher long-term risk of stroke (both ischaemic and haemorrhagic) and worse overall prognosis.1 –5 (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 18, 2021 Category: Cardiology Source Type: research

Connecting the dots? Rate control, heart failure, and atrial fibrillation
This editorial refers to ‘Role of atrial arrhythmia and ventricular response in atrial fibrillation induced atrial remodelling’ by J-B Guichardet al., pp. 462 –471. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 17, 2021 Category: Cardiology Source Type: research

SCORED and SOLOIST: the next scores for SGLT2 inhibitors
heart failurediabetesSGLT2clinical trialskidney disease (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 13, 2021 Category: Cardiology Source Type: research

Highlights of American Heart Association Scientific Sessions 2020: a virtual experience
American Heart AssociationClinical trialsCardiovascular medicineTranslational researchCOVID-19 (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 10, 2021 Category: Cardiology Source Type: research

PTGIR, a susceptibility gene for fibromuscular dysplasia?
This editorial refers to ‘Rare loss-of-function mutations of PTGIR are enriched in fibromuscular dysplasia’ by A. Georgeset al., pp.1154 –1165. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 4, 2021 Category: Cardiology Source Type: research

Co-ordinated mitochondrial degradation by autophagy and heterophagy in cardiac homeostasis
 AutophagyMacrophageMitochondriaMetabolismHeart (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 4, 2021 Category: Cardiology Source Type: research

Colchicine in coronary disease: another renaissance of an ancient drug
Coronary diseaseInflammationColchicineClinical trials (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 29, 2020 Category: Cardiology Source Type: research

Platelet CXCL14: introducing a new player and potential therapeutic target in thromboinflammation
This editorial refers to ‘The chemokine CXCL14 mediates platelet function and migration via direct interaction with CXCR4’ by A. Witteet al., pp.903 –917. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2020 Category: Cardiology Source Type: research

Scientists on the Spot: RNA modifications in atherosclerosis
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2020 Category: Cardiology Source Type: research

Circulating uromodulin: a cytokine trap for osteoinductive inflammatory mediators in chronic kidney disease?
This editorial refers to ‘Circulating uromodulin inhibits vascular calcification by interfering with pro-inflammatory cytokine signaling’ by I. Alesutanet al., pp.930 –941. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 24, 2020 Category: Cardiology Source Type: research

Erratum to: TNAP as a therapeutic target for cardiovascular calcification: a discussion of its pleiotropic functions in the body
DOI:10.1093/cvr/cvaa299 (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 22, 2020 Category: Cardiology Source Type: research

NRF2: a key regulator of endothelial microRNA transcription
This editorial refers to ‘NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli’ by S. Linna-Kuosmanenet al., pp.1339 –1357. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 22, 2020 Category: Cardiology Source Type: research

They eat, what we eat, they digest, what we ingest: the microbiome and the vulnerable plaque
This editorial refers to ‘Plasma levels of trimethylamine-N-oxide can be increased with ‘healthy’ and ‘unhealthy’ diets and do not correlate with the extent of atherosclerosis but with plaque instability’ by Y.C, Koayet al., pp. 435 –449. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 3, 2020 Category: Cardiology Source Type: research

Insights into therapeutic products, preclinical research models, and clinical trials in cardiac regenerative and reparative medicine: where are we now and the way ahead. Current opinion paper of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine
We report herein the main ideas and conclusions of that meeting. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 1, 2020 Category: Cardiology Source Type: research

Scientists on the Spot: Inflammation in atherosclerosis
 InflammationImmunomodulatoryAtherosclerosisESCCouncil on Basic Cardiovascular Science (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 1, 2020 Category: Cardiology Source Type: research

Life course psychological distress and cardiovascular disease risk factors in middle age: birth cohort study
Recent findings suggest that psychological distress in childhood —a combination of symptoms of anxiety and depression—particularly when persistent across the life course is related to an elevated rate of cardiovascular disease mortality in older age.1 Several mechanisms have been implicated with one possibility being that people who experience distress in early life, and particularly its recurrence across the life course, may become more susceptible to vascular disease via differences in physiological development. There is, however, a paucity of studies holding data on early distress and biological risk factors...
Source: Cardiovascular Research - November 27, 2020 Category: Cardiology Source Type: research

The endothelium as Achilles ’ heel in COVID-19 patients
COVID-19HeartEndothelial cellsEndotheliitis (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 27, 2020 Category: Cardiology Source Type: research

A vitaminic boost to rock the aortic wall
This editorial refers to ‘Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide ’ by T. Horimatsuet al., pp. 2226 –2238. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 27, 2020 Category: Cardiology Source Type: research